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Knoxville

$91+ Cheap flights from Florida Keys to Knoxville (TYS)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 9/15. Fares are subject to change and may not be available on all flights or dates of travel.
EYW — TYS
jun. 17 — jun. 241
mar. 6/17
mar. 6/24
1 adult, Economy
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Cheap flight deals from Florida Keys to Knoxville

Keep the following information in mind while searching for Florida Keys to Knoxville flight deals. Data was last updated junio 12, 2025.

Round-trip from

$159
(American Airlines)

One-way from

$91
(Mytrip)

Popular in

December

Cheapest in

August

Average price

$313
From Florida Keys to Knoxville McGhee Tyson
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One-way flight from Florida Keys to Knoxville McGhee Tyson
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Highest demand for flights based on searches. 24% potential increase in price ($114 potential increase over avg. RT price).
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Cheapest flight prices on average. 5% potential price decrease ($19 potential savings vs. average RT price).
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Average for round-trip flights in June 2025
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Find flight deals from Florida Keys to Knoxville

Cheapest flights from Florida Keys to Knoxville
Explore the most affordable flight options available from Florida Keys to Knoxville. Find the lowest fares from popular airlines and budget airlines, with prices last updated on junio 12, 2025.

This American Airlines deal was found by Cheapflights users on 6/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
jue. 7/1010:05 pmMIA - TYS
Nonstop1h 54mAmerican Airlines
lun. 7/146:05 amTYS - MIA
Nonstop2h 10mAmerican Airlines
Deal found 6/10$159
This Mytrip deal was found by Cheapflights users on 6/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
vie. 10/38:12 amEYW - TYS
Nonstop2h 15mAllegiant Air
dom. 10/59:25 pmTYS - EYW
1 stop11h 35mAllegiant Air
Deal found 6/11$169
This Delta deal was found by Cheapflights users on 6/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
jue. 7/107:23 pmMIA - TYS
1 stop4h 36mDelta
lun. 7/147:43 pmTYS - MIA
1 stop5h 12mDelta
Deal found 6/11$189
This Mytrip deal was found by Cheapflights users on 6/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
jue. 7/1012:46 pmMIA - TYS
1 stop28h 01mMultiple Airlines
vie. 7/255:02 pmTYS - MIA
1 stop27h 02mMultiple Airlines
Deal found 6/10$197
This Delta deal was found by Cheapflights users on 6/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
vie. 11/212:35 pmEYW - TYS
1 stop3h 38mDelta
lun. 11/2412:00 pmTYS - EYW
1 stop5h 12mDelta
Deal found 6/10$249
This American Airlines deal was found by Cheapflights users on 6/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
sáb. 11/227:33 pmEYW - TYS
1 stop3h 48mAmerican Airlines
mié. 11/262:23 pmTYS - EYW
1 stop4h 04mAmerican Airlines
Deal found 6/11$299
This Mytrip deal was found by Cheapflights users on 6/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
vie. 10/312:32 pmEYW - TYS
3 stops23h 23mMultiple Airlines
dom. 10/59:25 pmTYS - EYW
1 stop11h 35mMultiple Airlines
Deal found 6/11$356
This Frontier deal was found by Cheapflights users on 6/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Frontier is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
jue. 6/126:00 amMIA - TYS
1 stop10h 29mFrontier
dom. 6/155:25 pmTYS - MIA
1 stop13h 05mFrontier
Deal found 6/12$435
This United Airlines deal was found by Cheapflights users on 6/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
sáb. 8/1612:06 pmMIA - TYS
1 stop7h 55mUnited Airlines
mar. 8/197:00 amTYS - MIA
2 stops28h 20mUnited Airlines
Deal found 6/12$446
This United Airlines deal was found by Cheapflights users on 6/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
mié. 6/252:12 pmEYW - TYS
2 stops9h 47mUnited Airlines
dom. 6/297:00 amTYS - EYW
2 stops11h 05mUnited Airlines
Deal found 6/10$553

Cheapflights Fare Finder

Customize your flight search to find flights from Florida Keys to Knoxville that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated junio 12, 2025.
Use the filters below to find and compare flights from Florida Keys to Knoxville that are best for you.

Fly from

Florida Keys

Fly to

Knoxville

Route

Depart

Return

Price

MiamiKnoxville

MIA - TYS

MIATYS

Miami

vie. 7/11

10:05 pm-11:59 pm

Nonstop1h 54m

Knoxville McGhee Tyson

lun. 7/14

6:05 am-8:15 am

Nonstop2h 10m

$159

Key WestKnoxville

EYW - TYS

EYWTYS

Key West

vie. 10/3

8:12 am-10:27 am

Nonstop2h 15m

Knoxville McGhee Tyson

dom. 10/5

9:25 pm-9:00 am

1 stop11h 35m

$169

MiamiKnoxville

MIA - TYS

MIATYS

Miami

mié. 7/9

5:30 am-11:08 am

1 stop5h 38m

Knoxville McGhee Tyson

mié. 7/16

5:30 am-9:28 am

1 stop3h 58m

$189

MiamiKnoxville

MIA - TYS

MIATYS

Miami

jue. 7/10

12:46 pm-4:47 pm

1 stop28h 01m

Knoxville McGhee Tyson

vie. 7/25

5:02 pm-8:04 pm

1 stop27h 02m

$197

Key WestKnoxville

EYW - TYS

EYWTYS

Key West

vie. 11/21

2:35 pm-6:13 pm

1 stop3h 38m

Knoxville McGhee Tyson

lun. 11/24

12:00 pm-5:12 pm

1 stop5h 12m

$249

Key WestKnoxville

EYW - TYS

EYWTYS

Key West

sáb. 11/22

7:33 pm-11:21 pm

1 stop3h 48m

Knoxville McGhee Tyson

mié. 11/26

2:23 pm-6:27 pm

1 stop4h 04m

$299

Key WestKnoxville

EYW - TYS

EYWTYS

Key West

vie. 10/3

12:32 pm-11:55 am

3 stops23h 23m

Knoxville McGhee Tyson

dom. 10/5

9:25 pm-9:00 am

1 stop11h 35m

$356

MiamiKnoxville

MIA - TYS

MIATYS

Miami

jue. 7/10

7:45 am-8:57 pm

2 stops13h 12m

Knoxville McGhee Tyson

vie. 7/25

7:00 am-3:10 pm

1 stop8h 10m

$458

MiamiKnoxville

MIA - TYS

MIATYS

Miami

jue. 6/26

6:00 am-4:29 pm

1 stop10h 29m

Knoxville McGhee Tyson

dom. 6/29

5:25 pm-11:28 am

2 stops18h 03m

$542

Key WestKnoxville

EYW - TYS

EYWTYS

Key West

mié. 6/25

2:12 pm-11:59 pm

2 stops9h 47m

Knoxville McGhee Tyson

dom. 6/29

7:00 am-6:05 pm

2 stops11h 05m

$553

Flights are sorted by cheapest round-trip flights first.

Deals found on 6/11

Showing 1-10 of 20 results
1
2

Best time to book a flight from Florida Keys to Knoxville

Have a flexible travel schedule? Discover the best time to fly to Knoxville from Florida Keys with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Florida Keys to Knoxville

What is the cheapest month to book a flight from Florida Keys to Knoxville?

Currently, January is the cheapest month in which you can book a flight from Florida Keys to Knoxville (average of $296). Flying from Florida Keys to Knoxville in March is currently the most expensive (average of $376). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from EOA to TYS?

Find hourly flight availability from Florida Keys to Knoxville. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated junio 12, 2025.

Regardless of the time of day you decide to fly, the ticket price will remain around the same. Book flights from Florida Keys to Knoxville as you normally would.

Rainfall in Knoxville by month

Plan your trip to Knoxville by taking into account the average rainfall totals by month.

In terms of precipitation, rainfall in Knoxville ranges from 2.7 - 4.8 inches per month. March is typically the wettest month, when rainfall can reach 4.8 in. October is typically the driest time to visit Knoxville when rainfall is around 2.7 in.

Temperature in Knoxville by month

Plan your trip to Knoxville by taking into account the average temperature totals by month.

If weather is an important factor for your trip to Knoxville, use this chart to help with planning. For those seeking warmer temperatures, July is the ideal time of year to visit, when temperatures reach an average of 78.8 F. Travelers looking to avoid the cold should look outside of January, when temperatures are typically at their lowest (around 39.2 F).

Reviews of airlines servicing Knoxville

Get insights into the airlines that provide service to Knoxville. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Knoxville. Reviews last updated junio 12, 2025.
Read through reviews of airlines operating flights from Florida Keys to Knoxville, such as Delta, United Airlines and Allegiant Air. Users can see the overall rating for each airline as well as how each is rated in terms of entertainment options, comfort, food, crew/service, and boarding process.
Delta
8.0
Very good
7,950 reviews

Food

7.3

Boarding

8.2

Crew

8.5

Entertainment

7.9

Comfort

7.9

Overall

8.0

Reviews

1 / 20
6.0
Good

pilar,May 2025

RSW - ATL

The stewardess was not very nice because I requested two glasses of water. She didn’t even offer the snacks to me. She seemed angry and I felt very bad about her reaction. Also, the flight was full and you could not move. The airline should provide seats for obese people in consideration to the rest pf the passengers.
Delta
8.0
Very good
7,950 reviews
Delta
8.0
Very good
7,950 reviews

Food

7.3

Boarding

8.2

Crew

8.5

Entertainment

7.9

Comfort

7.9

Overall

8.0

Reviews

1 / 20
6.0
Good

pilar,May 2025

RSW - ATL

The stewardess was not very nice because I requested two glasses of water. She didn’t even offer the snacks to me. She seemed angry and I felt very bad about her reaction. Also, the flight was full and you could not move. The airline should provide seats for obese people in consideration to the rest pf the passengers.
United Airlines
7.4
Good
8,790 reviews
Delta
8.0
Very good
7,950 reviews

Food

7.3

Boarding

8.2

Crew

8.5

Entertainment

7.9

Comfort

7.9

Overall

8.0

Reviews

1 / 20
6.0
Good

pilar,May 2025

RSW - ATL

The stewardess was not very nice because I requested two glasses of water. She didn’t even offer the snacks to me. She seemed angry and I felt very bad about her reaction. Also, the flight was full and you could not move. The airline should provide seats for obese people in consideration to the rest pf the passengers.
Allegiant Air
7.3
Good
725 reviews
Delta
8.0
Very good
7,950 reviews

Food

7.3

Boarding

8.2

Crew

8.5

Entertainment

7.9

Comfort

7.9

Overall

8.0

Reviews

1 / 20
6.0
Good

pilar,May 2025

RSW - ATL

The stewardess was not very nice because I requested two glasses of water. She didn’t even offer the snacks to me. She seemed angry and I felt very bad about her reaction. Also, the flight was full and you could not move. The airline should provide seats for obese people in consideration to the rest pf the passengers.
American Airlines
7.2
Good
10,000 reviews
Delta
8.0
Very good
7,950 reviews

Food

7.3

Boarding

8.2

Crew

8.5

Entertainment

7.9

Comfort

7.9

Overall

8.0

Reviews

1 / 20
6.0
Good

pilar,May 2025

RSW - ATL

The stewardess was not very nice because I requested two glasses of water. She didn’t even offer the snacks to me. She seemed angry and I felt very bad about her reaction. Also, the flight was full and you could not move. The airline should provide seats for obese people in consideration to the rest pf the passengers.
Frontier
5.9
Fair
3,295 reviews
Delta
8.0
Very good
7,950 reviews

Food

7.3

Boarding

8.2

Crew

8.5

Entertainment

7.9

Comfort

7.9

Overall

8.0

Reviews

1 / 20
6.0
Good

pilar,May 2025

RSW - ATL

The stewardess was not very nice because I requested two glasses of water. She didn’t even offer the snacks to me. She seemed angry and I felt very bad about her reaction. Also, the flight was full and you could not move. The airline should provide seats for obese people in consideration to the rest pf the passengers.

Related info for your journey

Find useful and relevant information for your journey from Florida Keys to Knoxville. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airport do you fly into for flights to Knoxville from Florida Keys?

    Located just 11.3 mi from the city center, Knoxville McGhee Tyson (TYS) is the airport most travelers will use when flying to Knoxville from Florida Keys.

  • What are the cheapest airlines to fly from Florida Keys to Knoxville one-way?

    For one-way options, check prices for Frontier. According to our data, you can fly for as low as $167. Users have also found prices from $170 and $179 on Allegiant Air and Delta, respectively.

  • Can I find deals for flights from Florida Keys to Knoxville that include hotel bookings?

    Yes. In addition to deals on Florida Keys to Knoxville flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Florida Keys to Knoxville?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Florida Keys to Knoxville.

  • Can I find deals for business class flights from Florida Keys to Knoxville?

    Yes. Cheapflights offers flight deals from Florida Keys to Knoxville by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Florida Keys to Knoxville?

    Currently, January is the cheapest month in which you can book a flight from Florida Keys to Knoxville (average of $296). Flying from Florida Keys to Knoxville in March is currently the most expensive (average of $376). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Traveling to a place near Florida Keys?

Book flights to Florida Keys if you plan to visit one of these locations
Morristown
Cherokee
Corbin
Maryville
Oak Ridge
Alcoa
Murphy

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Alternative routes for Florida Keys to Knoxville

See prices for flight routes from nearby airports that may be better suited for you.
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Top 2 airlines flying from Florida Keys to Knoxville

Discover the top 2 airlines that operate flights from Florida Keys to Knoxville. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated junio 12, 2025.
AirlineCheapestAverageFlexibilityOn-time
DeltaCheapest$253Average$333FlexibilityNo cancel feeOn-timeN/A
American AirlinesCheapest$258Average$389FlexibilityNo cancel feeOn-time71%

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