Knoxville

$86+ Cheap flights from Florida Keys to Knoxville (TYS)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 3/4. Fares are subject to change and may not be available on all flights or dates of travel.
EYW — TYS
Mar 6 — Mar 131
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Cheap flight deals from Florida Keys to Knoxville

Cheapest flights from Florida Keys to Knoxville
Explore the most affordable flight options available from Florida Keys to Knoxville. Find the lowest fares from popular airlines and budget airlines, with prices last updated on February 4, 2026.

This Kiwi.com deal was found by Cheapflights users on 2/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 3/55:55 pm
MIA
-
TYS
1 stop18h 05m
Multiple Airlines
Mon 3/98:54 pm
TYS
-
MIA
2 stops16h 12m
Multiple Airlines
Deal found 2/2$220
This Southwest deal was found by Cheapflights users on 2/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 4/257:00 am
MIA
-
TYS
2 stops11h 30m
Southwest
Wed 4/297:05 am
TYS
-
MIA
1 stop5h 35m
Southwest
Deal found 2/3$233
This American Airlines deal was found by Cheapflights users on 2/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 4/256:54 am
MIA
-
TYS
1 stop4h 21m
American Airlines
Wed 4/296:15 am
TYS
-
MIA
Nonstop2h 08m
American Airlines
Deal found 2/2$255
This American Airlines deal was found by Cheapflights users on 2/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 2/199:43 pm
MIA
-
TYS
Nonstop2h 16m
American Airlines
Sun 2/225:45 am
TYS
-
MIA
Nonstop2h 10m
American Airlines
Deal found 2/3$269
This Kiwi.com deal was found by Cheapflights users on 2/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 2/65:41 pm
EYW
-
TYS
Nonstop2h 15m
Allegiant Air
Sun 2/88:30 am
TYS
-
EYW
1 stop13h 07m
Allegiant Air
Deal found 2/2$278
This American Airlines deal was found by Cheapflights users on 2/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 2/189:43 pm
MIA
-
TYS
Nonstop2h 16m
American Airlines
Sat 2/215:00 pm
TYS
-
MIA
1 stop6h 43m
American Airlines
Deal found 2/3$279
This Kiwi.com deal was found by Cheapflights users on 2/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 2/188:37 pm
MIA
-
TYS
1 stop15h 35m
Multiple Airlines
Fri 2/207:15 am
TYS
-
MIA
1 stop30h 06m
Multiple Airlines
Deal found 2/3$286
This Kiwi.com deal was found by Cheapflights users on 2/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 2/171:01 pm
EYW
-
TYS
2 stops21h 07m
Multiple Airlines
Sat 2/211:54 pm
TYS
-
EYW
1 stop24h 25m
Multiple Airlines
Deal found 2/2$289
This Kiwi.com deal was found by Cheapflights users on 2/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 5/75:30 am
MIA
-
TYS
1 stop10h 11m
Multiple Airlines
Sun 5/104:31 pm
TYS
-
MIA
2 stops25h 26m
Multiple Airlines
Deal found 2/3$293
This Southwest deal was found by Cheapflights users on 2/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 4/257:00 am
MIA
-
TYS
2 stops11h 30m
Southwest
Sat 5/27:45 am
TYS
-
MIA
1 stop6h 40m
Southwest
Deal found 2/3$294
This Southwest deal was found by Cheapflights users on 2/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 4/106:40 am
MIA
-
TYS
2 stops11h 30m
Southwest
Mon 4/1312:15 pm
TYS
-
MIA
1 stop9h 45m
Southwest
Deal found 2/2$297
This American Airlines deal was found by Cheapflights users on 2/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 2/177:45 pm
EYW
-
TYS
1 stop4h 14m
American Airlines
Sat 2/215:00 pm
TYS
-
EYW
1 stop5h 37m
American Airlines
Deal found 2/2$309

Find flight deals from Florida Keys to Knoxville

Keep the following information in mind while searching for Florida Keys to Knoxville flight deals. Data was last updated February 4, 2026.

Most accurate provider

FlightHub
3 stars

Most trusted provider

FlightHub
3 stars

Round-trip from

$220
(Kiwi.com)

One-way from

$86
(Kiwi.com)

Popular in

September

Cheapest in

December
Provider with most accurate pricing for Key West-Knoxville McGhee Tyson flight deals.
Provider most trusted by Cheapflights users for Key West-Knoxville McGhee Tyson flights.
From Florida Keys to Knoxville McGhee Tyson
One-way flight from Florida Keys to Knoxville McGhee Tyson
Highest demand for flights based on searches. 21% potential increase in price ($97 potential increase over avg. RT price).
Cheapest flight prices on average. 7% potential price decrease ($25 potential savings vs. average RT price).

Cheapflights Fare Finder

 
Customize your flight search to find flights from Florida Keys to Knoxville that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated February 4, 2026.
Use the filters below to find and compare flights from Florida Keys to Knoxville that are best for you.

Fly from

Florida Keys

Fly to

Knoxville

Route

Depart

Return

Price

MiamiKnoxville

MIA - TYS

MIATYS

Miami

Sat 4/25

7:00 am-6:30 pm

2 stops11h 30m

Knoxville McGhee Tyson

Wed 4/29

7:05 am-5:30 pm

2 stops10h 25m

$238

MiamiKnoxville

MIA - TYS

MIATYS

Miami

Wed 2/18

8:37 pm-12:12 pm

1 stop15h 35m

Knoxville McGhee Tyson

Fri 2/20

7:15 am-1:21 pm

1 stop30h 06m

$286

MiamiKnoxville

MIA - TYS

MIATYS

Miami

Sat 4/25

9:45 pm-11:59 pm

Nonstop2h 14m

Knoxville McGhee Tyson

Wed 4/29

6:15 am-8:23 am

Nonstop2h 08m

$289

Key WestKnoxville

EYW - TYS

EYWTYS

Key West

Tue 2/17

1:01 pm-10:08 am

2 stops21h 07m

Knoxville McGhee Tyson

Sat 2/21

1:54 pm-2:19 pm

1 stop24h 25m

$289

MiamiKnoxville

MIA - TYS

MIATYS

Miami

Fri 4/10

6:40 am-6:10 pm

2 stops11h 30m

Knoxville McGhee Tyson

Mon 4/13

12:15 pm-10:00 pm

1 stop9h 45m

$297

MiamiKnoxville

MIA - TYS

MIATYS

Miami

Wed 6/3

6:00 am-2:33 pm

1 stop8h 33m

Knoxville McGhee Tyson

Wed 6/10

5:30 am-3:43 pm

1 stop10h 13m

$305

Key WestKnoxville

EYW - TYS

EYWTYS

Key West

Tue 2/17

7:45 pm-11:59 pm

1 stop4h 14m

Knoxville McGhee Tyson

Sat 2/21

5:00 pm-10:37 pm

1 stop5h 37m

$309

MiamiKnoxville

MIA - TYS

MIATYS

Miami

Sat 6/6

7:36 pm-11:49 pm

1 stop4h 13m

Knoxville McGhee Tyson

Wed 6/10

5:30 am-3:43 pm

1 stop10h 13m

$318

MiamiKnoxville

MIA - TYS

MIATYS

Miami

Wed 6/3

6:00 am-2:33 pm

1 stop8h 33m

Knoxville McGhee Tyson

Tue 6/16

3:20 pm-9:32 pm

1 stop6h 12m

$318

MiamiKnoxville

MIA - TYS

MIATYS

Miami

Sat 4/25

6:00 am-11:17 am

1 stop5h 17m

Knoxville McGhee Tyson

Wed 4/29

4:38 pm-8:48 pm

1 stop4h 10m

$325

Flights are sorted by cheapest round-trip flights first.

Deals found on 2/3

Showing 1-10 of 21 results
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Best time to book a flight from Florida Keys to Knoxville

Have a flexible travel schedule? Discover the best time to fly to Knoxville from Florida Keys with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Florida Keys to Knoxville

What is the cheapest month to book a flight from Florida Keys to Knoxville?

Currently, November is the cheapest month in which you can book a flight from Florida Keys to Knoxville (average of $83). Flying from Florida Keys to Knoxville in July is currently the most expensive (average of $276). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from EOA to TYS?

Find hourly flight availability from Florida Keys to Knoxville. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated February 4, 2026.

Regardless of the time of day you decide to fly, the ticket price will remain around the same. Book flights from Florida Keys to Knoxville as you normally would.

Reviews of airlines servicing Knoxville

Get insights into the airlines that provide service to Knoxville. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Knoxville. Reviews last updated February 4, 2026.
See what other customers who have flown with Delta, American Airlines, and Allegiant Air from Florida Keys to Knoxville have to say. Users have also rated airlines in terms of entertainment options, comfort, food, crew/service, and boarding process.

Food

7.2

Overall

7.9

Entertainment

7.8

Crew

8.5

Boarding

8.1

Comfort

7.9

Reviews

1 / 20
6.0
Good

pilar,May 2025

RSW - ATL

The stewardess was not very nice because I requested two glasses of water. She didn’t even offer the snacks to me. She seemed angry and I felt very bad about her reaction. Also, the flight was full and you could not move. The airline should provide seats for obese people in consideration to the rest pf the passengers.

Food

7.2

Overall

7.9

Entertainment

7.8

Crew

8.5

Boarding

8.1

Comfort

7.9

Reviews

1 / 20
6.0
Good

pilar,May 2025

RSW - ATL

The stewardess was not very nice because I requested two glasses of water. She didn’t even offer the snacks to me. She seemed angry and I felt very bad about her reaction. Also, the flight was full and you could not move. The airline should provide seats for obese people in consideration to the rest pf the passengers.

Food

7.2

Overall

7.9

Entertainment

7.8

Crew

8.5

Boarding

8.1

Comfort

7.9

Reviews

1 / 20
6.0
Good

pilar,May 2025

RSW - ATL

The stewardess was not very nice because I requested two glasses of water. She didn’t even offer the snacks to me. She seemed angry and I felt very bad about her reaction. Also, the flight was full and you could not move. The airline should provide seats for obese people in consideration to the rest pf the passengers.

Food

7.2

Overall

7.9

Entertainment

7.8

Crew

8.5

Boarding

8.1

Comfort

7.9

Reviews

1 / 20
6.0
Good

pilar,May 2025

RSW - ATL

The stewardess was not very nice because I requested two glasses of water. She didn’t even offer the snacks to me. She seemed angry and I felt very bad about her reaction. Also, the flight was full and you could not move. The airline should provide seats for obese people in consideration to the rest pf the passengers.

Related info for your journey

Find useful and relevant information for your journey from Florida Keys to Knoxville. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.
  • What airport do you fly into for flights to Knoxville from Florida Keys?

    Located just 11.3 mi from the city center, Knoxville McGhee Tyson (TYS) is the airport most travelers will use when flying to Knoxville from Florida Keys.

  • How long is the flight from Florida Keys to Knoxville?

    Southwest and American Airlines can get you from Florida Keys to Knoxville in just under 2h 14m. Your travel time can differ by up to 9h 16m. The distance between Florida Keys and Knoxville is about 725 mi. Both multi-stop and nonstop flights can be found to your destination and back.

  • What are the cheapest airlines to fly from Florida Keys to Knoxville one-way?

    For one-way options, check prices for Allegiant Air. According to our data, you can fly for as low as $53. Users have also found prices from $89 and $99 on Delta and American Airlines, respectively.

  • Can I find deals for flights from Florida Keys to Knoxville that include hotel bookings?

    Yes. In addition to deals on Florida Keys to Knoxville flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Florida Keys to Knoxville?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Florida Keys to Knoxville.

  • Can I find deals for business class flights from Florida Keys to Knoxville?

    Yes. Cheapflights offers flight deals from Florida Keys to Knoxville by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Florida Keys to Knoxville?

    Currently, November is the cheapest month in which you can book a flight from Florida Keys to Knoxville (average of $83). Flying from Florida Keys to Knoxville in July is currently the most expensive (average of $276). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Traveling to a place near Knoxville?

Book flights to Knoxville if you plan to visit one of these locations
Cherokee
Crossville
Corbin
Morristown
Bryson City
Alcoa
Oak Ridge
Murphy

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Alternative routes for Florida Keys to Knoxville

See prices for flight routes from nearby airports that may be better suited for you.

Top 2 airlines flying from Florida Keys to Knoxville

Discover the top 2 airlines that operate flights from Florida Keys to Knoxville. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated February 4, 2026.
AirlineCheapestAverageFlexibilityOn-time
DeltaCheapest$273Average$498FlexibilityNo cancel feeOn-timeN/A
American AirlinesCheapest$298Average$389FlexibilityNo cancel feeOn-time71%

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