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Knoxville

$85+ Cheap flights from Florida Keys to Knoxville (TYS)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 12/12. Fares are subject to change and may not be available on all flights or dates of travel.
EYW — TYS
Dec 3 — Dec 101
Wed 12/3
Wed 12/10
1 adult, Economy
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Find flight deals from Florida Keys to Knoxville

Cheapest flights from Florida Keys to Knoxville
Explore the most affordable flight options available from Florida Keys to Knoxville. Find the lowest fares from popular airlines and budget airlines, with prices last updated on November 3, 2025.

This Kiwi.com deal was found by Cheapflights users on 11/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/2011:55 amMIA - TYS
2 stops10h 08mMultiple Airlines
Sun 11/235:49 pmTYS - MIA
1 stop21h 41mMultiple Airlines
Deal found 11/2$183
This Kiwi.com deal was found by Cheapflights users on 11/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 12/127:35 amMIA - TYS
1 stop11h 39mMultiple Airlines
Sun 12/145:23 pmTYS - MIA
2 stops17h 49mMultiple Airlines
Deal found 11/1$203
This American Airlines deal was found by Cheapflights users on 11/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 12/62:14 pmMIA - TYS
Nonstop2h 19mAmerican Airlines
Sat 12/135:03 pmTYS - MIA
Nonstop2h 17mAmerican Airlines
Deal found 11/3$208
This Kiwi.com deal was found by Cheapflights users on 11/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/176:00 amMIA - TYS
1 stop31h 11mMultiple Airlines
Wed 12/3112:01 pmTYS - MIA
2 stops12h 46mMultiple Airlines
Deal found 11/3$223
This Kiwi.com deal was found by Cheapflights users on 11/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/115:30 amMIA - TYS
2 stops10h 52mMultiple Airlines
Sun 12/145:23 pmTYS - MIA
1 stop25h 22mMultiple Airlines
Deal found 11/3$225
This Kiwi.com deal was found by Cheapflights users on 11/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 12/87:05 amMIA - TYS
1 stop12h 09mMultiple Airlines
Fri 12/121:05 pmTYS - MIA
2 stops19h 28mMultiple Airlines
Deal found 11/3$227
This American Airlines deal was found by Cheapflights users on 11/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 12/59:34 pmMIA - TYS
Nonstop2h 23mAmerican Airlines
Fri 12/125:03 pmTYS - MIA
Nonstop2h 17mAmerican Airlines
Deal found 11/1$230
This Kiwi.com deal was found by Cheapflights users on 11/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 12/215:45 amMIA - TYS
1 stop16h 11mMultiple Airlines
Wed 12/3112:01 pmTYS - MIA
2 stops22h 57mMultiple Airlines
Deal found 11/3$232
This Kiwi.com deal was found by Cheapflights users on 11/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 11/1411:31 amMIA - TYS
1 stop11h 25mMultiple Airlines
Sun 11/169:54 amTYS - MIA
2 stops25h 06mMultiple Airlines
Deal found 11/2$240
This American Airlines deal was found by Cheapflights users on 11/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 11/247:10 amEYW - TYS
1 stop4h 21mAmerican Airlines
Fri 11/286:00 amTYS - EYW
1 stop5h 14mAmerican Airlines
Deal found 11/3$496
This American Airlines deal was found by Cheapflights users on 11/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/247:52 pmEYW - TYS
1 stop4h 46mAmerican Airlines
Fri 12/264:12 pmTYS - EYW
1 stop6h 32mAmerican Airlines
Deal found 11/3$630
This United Airlines deal was found by Cheapflights users on 11/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/241:25 pmEYW - TYS
1 stop25h 23mUnited Airlines
Fri 12/265:45 amTYS - EYW
1 stop10h 44mUnited Airlines
Deal found 11/2$812

Cheap flight deals from Florida Keys to Knoxville

Keep the following information in mind while searching for Florida Keys to Knoxville flight deals. Data was last updated November 3, 2025.

Most accurate provider

eDreams
3 stars

Most trusted provider

eDreams
3 stars

Round-trip from

$179
(American Airlines)

One-way from

$85
(Kiwi.com)

Popular in

September

Cheapest in

October

Average price

$418
Provider with most accurate pricing for Key West-Knoxville McGhee Tyson flight deals.
Search Deals
Provider most trusted by Cheapflights users for Key West-Knoxville McGhee Tyson flights.
Search Deals
From Florida Keys to Knoxville McGhee Tyson
Search Deals
One-way flight from Florida Keys to Knoxville McGhee Tyson
Search Deals
Highest demand for flights based on searches. 16% potential increase in price ($77 potential increase over avg. RT price).
Search Deals
Cheapest flight prices on average. 5% potential price decrease ($20 potential savings vs. average RT price).
Search Deals
Average for round-trip flights in November 2025
Search Deals

Cheapflights Fare Finder

 
Customize your flight search to find flights from Florida Keys to Knoxville that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated November 3, 2025.
Use the filters below to find and compare flights from Florida Keys to Knoxville that are best for you.

Fly from

Florida Keys

Fly to

Knoxville

Route

Depart

Return

Price

MiamiKnoxville

MIA - TYS

MIATYS

Miami

Thu 1/8

12:00 pm-5:13 pm

1 stop5h 13m

Knoxville McGhee Tyson

Tue 1/13

5:30 am-12:14 pm

1 stop6h 44m

$199

MiamiKnoxville

MIA - TYS

MIATYS

Miami

Thu 1/8

9:34 pm-11:59 pm

Nonstop2h 25m

Knoxville McGhee Tyson

Sun 1/11

2:57 pm-9:10 pm

1 stop6h 13m

$234

MiamiKnoxville

MIA - TYS

MIATYS

Miami

Fri 12/12

8:05 am-2:52 pm

1 stop6h 47m

Knoxville McGhee Tyson

Sun 12/14

7:59 pm-12:46 am

1 stop4h 47m

$249

Key WestKnoxville

EYW - TYS

EYWTYS

Key West

Fri 2/20

7:10 am-1:52 pm

1 stop6h 42m

Knoxville McGhee Tyson

Tue 2/24

6:00 am-12:48 pm

1 stop6h 48m

$275

MiamiKnoxville

MIA - TYS

MIATYS

Miami

Sun 12/21

5:45 am-9:56 pm

1 stop16h 11m

Knoxville McGhee Tyson

Sat 1/3

2:23 pm-12:47 am

2 stops10h 24m

$279

MiamiKnoxville

MIA - TYS

MIATYS

Miami

Fri 12/5

3:27 pm-10:55 pm

1 stop7h 28m

Knoxville McGhee Tyson

Fri 12/12

5:03 pm-7:20 pm

Nonstop2h 17m

$285

Key WestKnoxville

EYW - TYS

EYWTYS

Key West

Fri 2/20

1:58 pm-8:03 pm

1 stop6h 05m

Knoxville McGhee Tyson

Tue 2/24

12:15 pm-7:24 pm

2 stops7h 09m

$306

MiamiKnoxville

MIA - TYS

MIATYS

Miami

Sat 11/29

9:40 pm-11:59 pm

Nonstop2h 19m

Knoxville McGhee Tyson

Sat 12/6

5:03 pm-7:20 pm

Nonstop2h 17m

$309

MiamiKnoxville

MIA - TYS

MIATYS

Miami

Wed 12/17

12:36 pm-6:58 pm

1 stop6h 22m

Knoxville McGhee Tyson

Wed 12/31

8:35 am-12:56 pm

1 stop4h 21m

$311

MiamiKnoxville

MIA - TYS

MIATYS

Miami

Fri 12/5

2:31 pm-12:03 pm

2 stops21h 32m

Knoxville McGhee Tyson

Fri 12/12

1:05 pm-3:03 pm

2 stops25h 58m

$314

Flights are sorted by cheapest round-trip flights first.

Deals found on 11/3

Showing 1-10 of 26 results
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2
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Best time to book a flight from Florida Keys to Knoxville

Have a flexible travel schedule? Discover the best time to fly to Knoxville from Florida Keys with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Florida Keys to Knoxville

What is the cheapest month to book a flight from Florida Keys to Knoxville?

Currently, November is the cheapest month in which you can book a flight from Florida Keys to Knoxville (average of $83). Flying from Florida Keys to Knoxville in July is currently the most expensive (average of $276). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from EOA to TYS?

Find hourly flight availability from Florida Keys to Knoxville. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated November 3, 2025.

It’s typically best to fly out from Florida Keys to Knoxville at noon. Doing so could potentially save you 66% on the flight price compared to flying in the evening, which is usually more expensive.

Reviews of airlines servicing Knoxville

Get insights into the airlines that provide service to Knoxville. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Knoxville. Reviews last updated November 3, 2025.
See what other customers who have flown with Delta, American Airlines, and Allegiant Air from Florida Keys to Knoxville have to say. Users have also rated airlines in terms of entertainment options, comfort, food, crew/service, and boarding process.
Delta
7.9
Good
8,002 reviews

Comfort

7.9

Food

7.3

Overall

7.9

Crew

8.5

Entertainment

7.9

Boarding

8.2

Reviews

1 / 20
6.0
Good

pilar,May 2025

RSW - ATL

The stewardess was not very nice because I requested two glasses of water. She didn’t even offer the snacks to me. She seemed angry and I felt very bad about her reaction. Also, the flight was full and you could not move. The airline should provide seats for obese people in consideration to the rest pf the passengers.
Delta
7.9
Good
8,002 reviews
Delta
7.9
Good
8,002 reviews

Comfort

7.9

Food

7.3

Overall

7.9

Crew

8.5

Entertainment

7.9

Boarding

8.2

Reviews

1 / 20
6.0
Good

pilar,May 2025

RSW - ATL

The stewardess was not very nice because I requested two glasses of water. She didn’t even offer the snacks to me. She seemed angry and I felt very bad about her reaction. Also, the flight was full and you could not move. The airline should provide seats for obese people in consideration to the rest pf the passengers.
American Airlines
7.2
Good
11,038 reviews
Delta
7.9
Good
8,002 reviews

Comfort

7.9

Food

7.3

Overall

7.9

Crew

8.5

Entertainment

7.9

Boarding

8.2

Reviews

1 / 20
6.0
Good

pilar,May 2025

RSW - ATL

The stewardess was not very nice because I requested two glasses of water. She didn’t even offer the snacks to me. She seemed angry and I felt very bad about her reaction. Also, the flight was full and you could not move. The airline should provide seats for obese people in consideration to the rest pf the passengers.
Allegiant Air
7.2
Good
694 reviews
Delta
7.9
Good
8,002 reviews

Comfort

7.9

Food

7.3

Overall

7.9

Crew

8.5

Entertainment

7.9

Boarding

8.2

Reviews

1 / 20
6.0
Good

pilar,May 2025

RSW - ATL

The stewardess was not very nice because I requested two glasses of water. She didn’t even offer the snacks to me. She seemed angry and I felt very bad about her reaction. Also, the flight was full and you could not move. The airline should provide seats for obese people in consideration to the rest pf the passengers.

Related info for your journey

Find useful and relevant information for your journey from Florida Keys to Knoxville. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airport do you fly into for flights to Knoxville from Florida Keys?

    Located just 11.3 mi from the city center, Knoxville McGhee Tyson (TYS) is the airport most travelers will use when flying to Knoxville from Florida Keys.

  • How long is the flight from Florida Keys to Knoxville?

    Delta and American Airlines can get you from Florida Keys to Knoxville in just under 2h 25m. Your travel time can differ by up to 2h 48m. The distance between Florida Keys and Knoxville is about 725 mi. Both multi-stop and nonstop flights can be found to your destination and back.

  • What are the cheapest flights from Florida Keys to Knoxville?

    While on average a flight from Florida Keys to Knoxville is generally $96, our data shows the cheapest flight currently is $96. When looking at the most popular route, (Miami - Knoxville McGhee Tyson), you can expect to pay $183 for that flight.

  • Can I find deals for flights from Florida Keys to Knoxville that include hotel bookings?

    Yes. In addition to deals on Florida Keys to Knoxville flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Florida Keys to Knoxville?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Florida Keys to Knoxville.

  • Can I find deals for business class flights from Florida Keys to Knoxville?

    Yes. Cheapflights offers flight deals from Florida Keys to Knoxville by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Florida Keys to Knoxville?

    Currently, November is the cheapest month in which you can book a flight from Florida Keys to Knoxville (average of $83). Flying from Florida Keys to Knoxville in July is currently the most expensive (average of $276). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Traveling to a place near Knoxville?

Book flights to Knoxville if you plan to visit one of these locations
Morristown
Cherokee
Crossville
Corbin
Bryson City
Alcoa
Oak Ridge
Murphy

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Alternative routes for Florida Keys to Knoxville

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Top 2 airlines flying from Florida Keys to Knoxville

Discover the top 2 airlines that operate flights from Florida Keys to Knoxville. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated November 3, 2025.
AirlineCheapestAverageFlexibilityOn-time
DeltaCheapest$253Average$353FlexibilityNo cancel feeOn-timeN/A
American AirlinesCheapest$298Average$398FlexibilityNo cancel feeOn-time71%

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