Knoxville

$37+ Cheap flights from Florida Keys to Knoxville (TYS)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 4/17. Fares are subject to change and may not be available on all flights or dates of travel.
EYW — TYS
May 2 — May 91
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Cheap flight deals from Florida Keys to Knoxville

Cheapest flights from Florida Keys to Knoxville
Explore the most affordable flight options available from Florida Keys to Knoxville. Find the lowest fares from popular airlines and budget airlines, with prices last updated on April 2, 2026.

This Kiwi.com deal was found by Cheapflights users on 3/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 4/1711:01 am
EYW
-
TYS
Nonstop2h 15m
Allegiant Air
Mon 4/208:00 am
TYS
-
EYW
Nonstop2h 11m
Allegiant Air
Deal found 3/30$69
This Gotogate deal was found by Cheapflights users on 3/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Gotogate is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 4/1311:01 am
EYW
-
TYS
Nonstop2h 15m
Allegiant Air
Fri 4/178:00 am
TYS
-
EYW
Nonstop2h 11m
Allegiant Air
Deal found 3/29$129
This Kiwi.com deal was found by Cheapflights users on 3/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 3/3011:01 am
EYW
-
TYS
Nonstop2h 15m
Allegiant Air
Fri 4/108:00 am
TYS
-
EYW
Nonstop2h 11m
Allegiant Air
Deal found 3/29$155
This Frontier deal was found by Cheapflights users on 3/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Frontier is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 5/296:00 am
MIA
-
TYS
1 stop13h 33m
Frontier
Mon 6/18:32 pm
TYS
-
MIA
1 stop9h 01m
Frontier
Deal found 3/28$201
This Kiwi.com deal was found by Cheapflights users on 3/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 4/235:25 am
MIA
-
TYS
1 stop10h 16m
Multiple Airlines
Sun 4/2611:27 am
TYS
-
MIA
2 stops13h 22m
Multiple Airlines
Deal found 3/28$202
This Kiwi.com deal was found by Cheapflights users on 3/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 4/1711:01 am
EYW
-
TYS
Nonstop2h 15m
Multiple Airlines
Mon 4/201:15 pm
TYS
-
EYW
3 stops23h 06m
Multiple Airlines
Deal found 3/30$205
This Kiwi.com deal was found by Cheapflights users on 3/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 5/75:05 am
MIA
-
TYS
2 stops15h 45m
Multiple Airlines
Sun 5/1011:27 am
TYS
-
MIA
1 stop10h 45m
Multiple Airlines
Deal found 3/28$212
This Frontier deal was found by Cheapflights users on 4/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Frontier is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 4/105:50 am
MIA
-
TYS
1 stop9h 38m
Frontier
Mon 4/134:20 pm
TYS
-
MIA
1 stop13h 29m
Frontier
Deal found 4/1$222
This Kiwi.com deal was found by Cheapflights users on 3/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 4/911:01 am
EYW
-
TYS
1 stop11h 32m
Multiple Airlines
Sun 4/124:31 pm
TYS
-
EYW
1 stop16h 38m
Multiple Airlines
Deal found 3/30$227
This Kiwi.com deal was found by Cheapflights users on 3/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 4/29:46 am
EYW
-
TYS
1 stop8h 13m
Multiple Airlines
Mon 4/68:00 am
TYS
-
EYW
Nonstop2h 11m
Multiple Airlines
Deal found 3/30$232
This Priceline deal was found by Cheapflights users on 3/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Priceline is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 4/35:50 am
MIA
-
TYS
1 stop9h 38m
Frontier
Mon 4/64:20 pm
TYS
-
MIA
1 stop13h 29m
Frontier
Deal found 3/29$240
This Kiwi.com deal was found by Cheapflights users on 3/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 6/188:00 am
MIA
-
TYS
1 stop12h 48m
Multiple Airlines
Sun 6/214:05 pm
TYS
-
MIA
1 stop28h 28m
Multiple Airlines
Deal found 3/29$265

Find flight deals from Florida Keys to Knoxville

Keep the following information in mind while searching for Florida Keys to Knoxville flight deals. Data was last updated April 2, 2026.

Most accurate provider

FlightHub
3 stars

Most trusted provider

FlightHub
3 stars

Round-trip from

$69
(Kiwi.com)

One-way from

$37
(Kiwi.com)

Popular in

September

Cheapest in

March

Average price

$248
Provider with most accurate pricing for Key West-Knoxville McGhee Tyson flight deals.
Provider most trusted by Cheapflights users for Key West-Knoxville McGhee Tyson flights.
From Florida Keys to Knoxville McGhee Tyson
One-way flight from Florida Keys to Knoxville McGhee Tyson
Highest demand for flights based on searches. 25% potential increase in price ($117 potential increase over avg. RT price).
Cheapest flight prices on average. 8% potential price decrease ($27 potential savings vs. average RT price).
Average for round-trip flights in April 2026

Cheapflights Fare Finder

 
Customize your flight search to find flights from Florida Keys to Knoxville that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated April 2, 2026.
Use the filters below to find and compare flights from Florida Keys to Knoxville that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Cheapest round-trip
Quickest round-trip

Key WestKnoxville

EYW - TYS

EYWTYS

Key West

Mon 4/13

11:01 am-1:16 pm

Nonstop2h 15m

Knoxville McGhee Tyson

Fri 4/17

8:00 am-10:11 am

Nonstop2h 11m

$129

Key WestKnoxville

EYW - TYS

EYWTYS

Key West

Fri 4/17

11:01 am-1:16 pm

Nonstop2h 15m

Knoxville McGhee Tyson

Mon 4/20

7:30 am-12:21 pm

2 stops28h 51m

$208

MiamiKnoxville

MIA - TYS

MIATYS

Miami

Tue 4/28

12:10 pm-8:50 pm

2 stops8h 40m

Knoxville McGhee Tyson

Tue 5/5

8:15 am-8:40 pm

2 stops12h 25m

$305

Key WestKnoxville

EYW - TYS

EYWTYS

Key West

Mon 8/3

6:18 pm-11:52 pm

1 stop5h 34m

Knoxville McGhee Tyson

Tue 8/11

5:30 am-10:58 am

1 stop5h 28m

$326

MiamiKnoxville

MIA - TYS

MIATYS

Miami

Fri 5/8

6:40 am-6:10 pm

2 stops11h 30m

Knoxville McGhee Tyson

Tue 5/12

8:15 am-2:15 pm

1 stop6h 00m

$337

Key WestKnoxville

EYW - TYS

EYWTYS

Key West

Wed 4/15

7:33 am-2:20 pm

1 stop6h 47m

Knoxville McGhee Tyson

Sun 4/19

5:40 am-10:46 am

1 stop5h 06m

$339

MiamiKnoxville

MIA - TYS

MIATYS

Miami

Sat 5/2

9:30 am-6:30 pm

1 stop9h 00m

Knoxville McGhee Tyson

Mon 5/4

6:35 am-4:50 pm

2 stops10h 15m

$355

Key WestKnoxville

EYW - TYS

EYWTYS

Key West

Mon 8/3

7:40 pm-11:59 pm

1 stop4h 19m

Knoxville McGhee Tyson

Tue 8/11

9:35 am-6:39 pm

2 stops9h 04m

$384

MiamiKnoxville

MIA - TYS

MIATYS

Miami

Mon 4/27

6:40 am-6:10 pm

2 stops11h 30m

Knoxville McGhee Tyson

Thu 4/30

8:05 am-2:30 pm

1 stop6h 25m

$389

MiamiKnoxville

MIA - TYS

MIATYS

Miami

Sat 4/25

6:54 am-2:24 pm

1 stop7h 30m

Knoxville McGhee Tyson

Wed 4/29

7:00 am-1:12 pm

1 stop6h 12m

$399

Flights are sorted by cheapest round-trip flights first.

Deals found on 3/30

Showing 1-10 of 35 resultsSorted by cheapest first
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Best time to book a flight from Florida Keys to Knoxville

Have a flexible travel schedule? Discover the best time to fly to Knoxville from Florida Keys with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Florida Keys to Knoxville

What is the cheapest time of day to fly from EOA to TYS?

Find hourly flight availability from Florida Keys to Knoxville. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated April 2, 2026.

Regardless of the time of day you decide to fly, the ticket price will remain around the same. Book flights from Florida Keys to Knoxville as you normally would.

Reviews of airlines servicing Knoxville

Get insights into the airlines that provide service to Knoxville. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Knoxville. Reviews last updated April 2, 2026.
See what other customers who have flown with Delta,Allegiant Air, andAmerican Airlines from Florida Keys to Knoxville have to say. Users have also rated airlines in terms of entertainment options, comfort, food, crew/service, and boarding process.

Overall

7.9

Boarding

8.1

Crew

8.5

Entertainment

7.8

Comfort

7.9

Food

7.2

Reviews

1 / 20
6.0
Good

pilar,May 2025

RSW - ATL

The stewardess was not very nice because I requested two glasses of water. She didn’t even offer the snacks to me. She seemed angry and I felt very bad about her reaction. Also, the flight was full and you could not move. The airline should provide seats for obese people in consideration to the rest pf the passengers.

Overall

7.9

Boarding

8.1

Crew

8.5

Entertainment

7.8

Comfort

7.9

Food

7.2

Reviews

1 / 20
6.0
Good

pilar,May 2025

RSW - ATL

The stewardess was not very nice because I requested two glasses of water. She didn’t even offer the snacks to me. She seemed angry and I felt very bad about her reaction. Also, the flight was full and you could not move. The airline should provide seats for obese people in consideration to the rest pf the passengers.

Overall

7.9

Boarding

8.1

Crew

8.5

Entertainment

7.8

Comfort

7.9

Food

7.2

Reviews

1 / 20
6.0
Good

pilar,May 2025

RSW - ATL

The stewardess was not very nice because I requested two glasses of water. She didn’t even offer the snacks to me. She seemed angry and I felt very bad about her reaction. Also, the flight was full and you could not move. The airline should provide seats for obese people in consideration to the rest pf the passengers.

Overall

7.9

Boarding

8.1

Crew

8.5

Entertainment

7.8

Comfort

7.9

Food

7.2

Reviews

1 / 20
6.0
Good

pilar,May 2025

RSW - ATL

The stewardess was not very nice because I requested two glasses of water. She didn’t even offer the snacks to me. She seemed angry and I felt very bad about her reaction. Also, the flight was full and you could not move. The airline should provide seats for obese people in consideration to the rest pf the passengers.

Related info for your journey

Find useful and relevant information for your journey from Florida Keys to Knoxville. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.
  • What airport do you fly into for flights to Knoxville from Florida Keys?

    Located just 11.3 mi from the city center, Knoxville McGhee Tyson (TYS) is the airport most travelers will use when flying to Knoxville from Florida Keys.

  • How long is the flight from Florida Keys to Knoxville?

    Allegiant Air, Southwest, and American Airlines can get you from Florida Keys to Knoxville in just under 2h 15m. Your travel time can differ by up to 6h 25m. The distance between Florida Keys and Knoxville is about 788 mi. Both multi-stop and nonstop flights can be found to your destination and back.

  • What are the cheapest airlines to fly from Florida Keys to Knoxville one-way?

    For one-way options, check prices for Allegiant Air. According to our data, you can fly for as low as $41. Users have also found prices from $89 and $164 on Delta and American Airlines, respectively.

  • Can I find deals for flights from Florida Keys to Knoxville that include hotel bookings?

    Yes. In addition to deals on Florida Keys to Knoxville flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Florida Keys to Knoxville?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Florida Keys to Knoxville.

  • Can I find deals for business class flights from Florida Keys to Knoxville?

    Yes. Cheapflights offers flight deals from Florida Keys to Knoxville by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

See more FAQs

Traveling to a place near Knoxville?

Book flights to Knoxville if you plan to visit one of these locations
Cherokee
Crossville
Corbin
Morristown
Bryson City
Alcoa
Murphy
Oak Ridge

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Alternative routes for Florida Keys to Knoxville

See prices for flight routes from nearby airports that may be better suited for you.

Top 2 airlines flying from Florida Keys to Knoxville

Discover the top 2 airlines that operate flights from Florida Keys to Knoxville. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated April 2, 2026.
AirlineCheapestAverageFlexibilityOn-time
American AirlinesCheapest$248Average$485FlexibilityNo cancel feeOn-time71%
DeltaCheapest$273Average$498FlexibilityNo cancel feeOn-timeN/A

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