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Knoxville

$114+ Cheap flights from Florida Keys to Knoxville (TYS)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 8/30. Fares are subject to change and may not be available on all flights or dates of travel.
EYW — TYS
Aug 6 — Aug 131
Wed 8/6
Wed 8/13
1 adult, Economy
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Cheap flight deals from Florida Keys to Knoxville

Keep the following information in mind while searching for Florida Keys to Knoxville flight deals. Data was last updated August 1, 2025.

Round-trip from

$159
(American Airlines)

One-way from

$114
(Delta)

Popular in

December

Cheapest in

October

Average price

$263
From Florida Keys to Knoxville McGhee Tyson
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One-way flight from Florida Keys to Knoxville McGhee Tyson
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Highest demand for flights based on searches. 15% potential increase in price ($62 potential increase over avg. RT price).
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Cheapest flight prices on average. 5% potential price decrease ($20 potential savings vs. average RT price).
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Average for round-trip flights in August 2025
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Find flight deals from Florida Keys to Knoxville

Cheapest flights from Florida Keys to Knoxville
Explore the most affordable flight options available from Florida Keys to Knoxville. Find the lowest fares from popular airlines and budget airlines, with prices last updated on August 1, 2025.

This American Airlines deal was found by Cheapflights users on 7/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 8/299:30 pmMIA - TYS
Nonstop2h 16mAmerican Airlines
Tue 9/27:00 amTYS - MIA
Nonstop2h 08mAmerican Airlines
Deal found 7/30$159
This Delta deal was found by Cheapflights users on 7/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 9/256:25 pmMIA - TYS
1 stop5h 19mDelta
Mon 9/295:45 amTYS - MIA
1 stop3h 35mDelta
Deal found 7/30$179
This Mytrip deal was found by Cheapflights users on 7/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 11/1411:28 amMIA - TYS
2 stops22h 36mMultiple Airlines
Mon 11/172:22 pmTYS - MIA
2 stops20h 01mMultiple Airlines
Deal found 7/31$254
This Frontier deal was found by Cheapflights users on 8/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Frontier is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 8/216:00 amMIA - TYS
1 stop13h 41mFrontier
Sun 8/248:33 pmTYS - MIA
1 stop9h 57mFrontier
Deal found 8/1$257
This American Airlines deal was found by Cheapflights users on 7/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/167:52 pmEYW - TYS
1 stop3h 43mAmerican Airlines
Mon 10/206:15 amTYS - EYW
1 stop6h 40mAmerican Airlines
Deal found 7/30$274
This United Airlines deal was found by Cheapflights users on 7/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 11/1411:09 amMIA - TYS
2 stops12h 50mUnited Airlines
Mon 11/175:45 amTYS - MIA
1 stop5h 29mUnited Airlines
Deal found 7/31$312
This Delta deal was found by Cheapflights users on 7/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 8/147:00 amEYW - TYS
1 stop3h 44mDelta
Thu 8/211:53 pmTYS - EYW
1 stop6h 19mDelta
Deal found 7/30$389
This United Airlines deal was found by Cheapflights users on 7/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 8/142:22 pmEYW - TYS
3 stops32h 15mUnited Airlines
Thu 8/217:25 pmTYS - EYW
2 stops19h 00mUnited Airlines
Deal found 7/31$773

Cheapflights Fare Finder

 
Customize your flight search to find flights from Florida Keys to Knoxville that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated August 1, 2025.
Use the filters below to find and compare flights from Florida Keys to Knoxville that are best for you.

Fly from

Florida Keys

Fly to

Knoxville

Route

Depart

Return

Price

MiamiKnoxville

MIA - TYS

MIATYS

Miami

Fri 8/29

9:30 pm-11:46 pm

Nonstop2h 16m

Knoxville McGhee Tyson

Tue 9/2

7:00 am-9:08 am

Nonstop2h 08m

$159

MiamiKnoxville

MIA - TYS

MIATYS

Miami

Thu 9/25

6:25 pm-11:44 pm

1 stop5h 19m

Knoxville McGhee Tyson

Mon 9/29

5:45 am-9:20 am

1 stop3h 35m

$179

MiamiKnoxville

MIA - TYS

MIATYS

Miami

Thu 8/21

6:00 am-7:41 pm

1 stop13h 41m

Knoxville McGhee Tyson

Sun 8/24

8:33 pm-6:30 am

1 stop9h 57m

$257

MiamiKnoxville

MIA - TYS

MIATYS

Miami

Thu 9/25

5:59 pm-10:33 am

2 stops16h 34m

Knoxville McGhee Tyson

Mon 9/29

7:15 am-5:02 pm

1 stop9h 47m

$275

Key WestKnoxville

EYW - TYS

EYWTYS

Key West

Thu 8/14

7:00 am-10:44 am

1 stop3h 44m

Knoxville McGhee Tyson

Thu 8/21

1:53 pm-8:12 pm

1 stop6h 19m

$389

Key WestKnoxville

EYW - TYS

EYWTYS

Key West

Thu 8/14

11:26 am-7:45 pm

2 stops8h 19m

Knoxville McGhee Tyson

Thu 8/21

7:00 am-10:53 am

1 stop3h 53m

$451

Key WestKnoxville

EYW - TYS

EYWTYS

Key West

Thu 8/14

2:22 pm-10:37 pm

3 stops32h 15m

Knoxville McGhee Tyson

Thu 8/21

7:25 pm-2:25 pm

2 stops19h 00m

$773

MiamiKnoxville

MIA - TYS

MIATYS

Miami

Sat 8/30

6:00 am-10:27 am

1 stop4h 27m

$114

MiamiKnoxville

MIA - TYS

MIATYS

Miami

Tue 8/19

7:53 pm-11:54 am

1 stop16h 01m

$124

MiamiKnoxville

MIA - TYS

MIATYS

Miami

Sun 9/28

6:00 am-4:18 pm

1 stop10h 18m

$129

Flights are sorted by cheapest round-trip flights first.

Deals found on 7/31

Showing 1-10 of 16 results
1
2

Best time to book a flight from Florida Keys to Knoxville

Have a flexible travel schedule? Discover the best time to fly to Knoxville from Florida Keys with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Florida Keys to Knoxville

What is the cheapest month to book a flight from Florida Keys to Knoxville?

Currently, January is the cheapest month in which you can book a flight from Florida Keys to Knoxville (average of $294). Flying from Florida Keys to Knoxville in March is currently the most expensive (average of $376). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from EOA to TYS?

Find hourly flight availability from Florida Keys to Knoxville. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated August 1, 2025.

Regardless of the time of day you decide to fly, the ticket price will remain around the same. Book flights from Florida Keys to Knoxville as you normally would.

Reviews of airlines servicing Knoxville

Get insights into the airlines that provide service to Knoxville. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Knoxville. Reviews last updated August 1, 2025.
See what other customers who have flown with Delta, United Airlines, and American Airlines from Florida Keys to Knoxville have to say. Users have also rated airlines in terms of entertainment options, comfort, food, crew/service, and boarding process.
Delta
8.0
Very good
7,983 reviews

Comfort

7.9

Entertainment

7.9

Overall

8.0

Food

7.3

Boarding

8.2

Crew

8.5

Reviews

1 / 20
6.0
Good

pilar,May 2025

RSW - ATL

The stewardess was not very nice because I requested two glasses of water. She didn’t even offer the snacks to me. She seemed angry and I felt very bad about her reaction. Also, the flight was full and you could not move. The airline should provide seats for obese people in consideration to the rest pf the passengers.
Delta
8.0
Very good
7,983 reviews
Delta
8.0
Very good
7,983 reviews

Comfort

7.9

Entertainment

7.9

Overall

8.0

Food

7.3

Boarding

8.2

Crew

8.5

Reviews

1 / 20
6.0
Good

pilar,May 2025

RSW - ATL

The stewardess was not very nice because I requested two glasses of water. She didn’t even offer the snacks to me. She seemed angry and I felt very bad about her reaction. Also, the flight was full and you could not move. The airline should provide seats for obese people in consideration to the rest pf the passengers.
United Airlines
7.4
Good
8,904 reviews
Delta
8.0
Very good
7,983 reviews

Comfort

7.9

Entertainment

7.9

Overall

8.0

Food

7.3

Boarding

8.2

Crew

8.5

Reviews

1 / 20
6.0
Good

pilar,May 2025

RSW - ATL

The stewardess was not very nice because I requested two glasses of water. She didn’t even offer the snacks to me. She seemed angry and I felt very bad about her reaction. Also, the flight was full and you could not move. The airline should provide seats for obese people in consideration to the rest pf the passengers.
American Airlines
7.2
Good
10,000 reviews
Delta
8.0
Very good
7,983 reviews

Comfort

7.9

Entertainment

7.9

Overall

8.0

Food

7.3

Boarding

8.2

Crew

8.5

Reviews

1 / 20
6.0
Good

pilar,May 2025

RSW - ATL

The stewardess was not very nice because I requested two glasses of water. She didn’t even offer the snacks to me. She seemed angry and I felt very bad about her reaction. Also, the flight was full and you could not move. The airline should provide seats for obese people in consideration to the rest pf the passengers.
Allegiant Air
7.2
Good
702 reviews
Delta
8.0
Very good
7,983 reviews

Comfort

7.9

Entertainment

7.9

Overall

8.0

Food

7.3

Boarding

8.2

Crew

8.5

Reviews

1 / 20
6.0
Good

pilar,May 2025

RSW - ATL

The stewardess was not very nice because I requested two glasses of water. She didn’t even offer the snacks to me. She seemed angry and I felt very bad about her reaction. Also, the flight was full and you could not move. The airline should provide seats for obese people in consideration to the rest pf the passengers.
Frontier
5.9
Fair
3,241 reviews
Delta
8.0
Very good
7,983 reviews

Comfort

7.9

Entertainment

7.9

Overall

8.0

Food

7.3

Boarding

8.2

Crew

8.5

Reviews

1 / 20
6.0
Good

pilar,May 2025

RSW - ATL

The stewardess was not very nice because I requested two glasses of water. She didn’t even offer the snacks to me. She seemed angry and I felt very bad about her reaction. Also, the flight was full and you could not move. The airline should provide seats for obese people in consideration to the rest pf the passengers.

Related info for your journey

Find useful and relevant information for your journey from Florida Keys to Knoxville. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airport do you fly into for flights to Knoxville from Florida Keys?

    Located just 11.3 mi from the city center, Knoxville McGhee Tyson (TYS) is the airport most travelers will use when flying to Knoxville from Florida Keys.

  • What are the cheapest airlines to fly from Florida Keys to Knoxville one-way?

    For one-way options, check prices for Delta. According to our data, you can fly for as low as $114. Users have also found prices from $129 and $154 on Frontier and United Airlines, respectively.

  • Can I find deals for flights from Florida Keys to Knoxville that include hotel bookings?

    Yes. In addition to deals on Florida Keys to Knoxville flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Florida Keys to Knoxville?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Florida Keys to Knoxville.

  • Can I find deals for business class flights from Florida Keys to Knoxville?

    Yes. Cheapflights offers flight deals from Florida Keys to Knoxville by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Florida Keys to Knoxville?

    Currently, January is the cheapest month in which you can book a flight from Florida Keys to Knoxville (average of $294). Flying from Florida Keys to Knoxville in March is currently the most expensive (average of $376). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Traveling to a place near Knoxville?

Book flights to Knoxville if you plan to visit one of these locations
Morristown
Cherokee
Corbin
Alcoa
Oak Ridge
Murphy

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Top 2 airlines flying from Florida Keys to Knoxville

Discover the top 2 airlines that operate flights from Florida Keys to Knoxville. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated August 1, 2025.
AirlineCheapestAverageFlexibilityOn-time
DeltaCheapest$253Average$333FlexibilityNo cancel feeOn-timeN/A
American AirlinesCheapest$258Average$389FlexibilityNo cancel feeOn-time71%

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