$86+ Cheap flights from Florida Keys to Knoxville (TYS)
This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 3/4. Fares are subject to change and may not be available on all flights or dates of travel.
EYW — TYS
Mar 6 — Mar 131
1 adult, Economy
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Find cheap flights from Florida Keys to Knoxville with Cheapflights
1. Tell us where you want to go
Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”2. Select your favorite providers
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Cheapest flights from Florida Keys to KnoxvilleExplore the most affordable flight options available from Florida Keys to Knoxville. Find the lowest fares from popular airlines and budget airlines, with prices last updated on February 4, 2026.
Explore the most affordable flight options available from Florida Keys to Knoxville. Find the lowest fares from popular airlines and budget airlines, with prices last updated on February 4, 2026.
This Kiwi.com deal was found by Cheapflights users on 2/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 3/55:55 pm
MIA
- TYS
1 stop18h 05m
Multiple Airlines
Mon 3/98:54 pm
TYS
- MIA
2 stops16h 12m
Multiple Airlines
Deal found 2/2![Multiple Airlines logo]()
$220
This Southwest deal was found by Cheapflights users on 2/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 4/257:00 am
MIA
- TYS
2 stops11h 30m
Southwest
Wed 4/297:05 am
TYS
- MIA
1 stop5h 35m
Southwest
Deal found 2/3![Southwest logo]()
$233
This American Airlines deal was found by Cheapflights users on 2/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 4/256:54 am
MIA
- TYS
1 stop4h 21m
American Airlines
Wed 4/296:15 am
TYS
- MIA
Nonstop2h 08m
American Airlines
Deal found 2/2![American Airlines logo]()
$255
This American Airlines deal was found by Cheapflights users on 2/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 2/199:43 pm
MIA
- TYS
Nonstop2h 16m
American Airlines
Sun 2/225:45 am
TYS
- MIA
Nonstop2h 10m
American Airlines
Deal found 2/3![American Airlines logo]()
$269
This Kiwi.com deal was found by Cheapflights users on 2/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 2/65:41 pm
EYW
- TYS
Nonstop2h 15m
Allegiant Air
Sun 2/88:30 am
TYS
- EYW
1 stop13h 07m
Allegiant Air
Deal found 2/2![Allegiant Air logo]()
$278
This American Airlines deal was found by Cheapflights users on 2/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 2/189:43 pm
MIA
- TYS
Nonstop2h 16m
American Airlines
Sat 2/215:00 pm
TYS
- MIA
1 stop6h 43m
American Airlines
Deal found 2/3![American Airlines logo]()
$279
This Kiwi.com deal was found by Cheapflights users on 2/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 2/188:37 pm
MIA
- TYS
1 stop15h 35m
Multiple Airlines
Fri 2/207:15 am
TYS
- MIA
1 stop30h 06m
Multiple Airlines
Deal found 2/3![Multiple Airlines logo]()
$286
This Kiwi.com deal was found by Cheapflights users on 2/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 2/171:01 pm
EYW
- TYS
2 stops21h 07m
Multiple Airlines
Sat 2/211:54 pm
TYS
- EYW
1 stop24h 25m
Multiple Airlines
Deal found 2/2![Multiple Airlines logo]()
$289
This Kiwi.com deal was found by Cheapflights users on 2/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 5/75:30 am
MIA
- TYS
1 stop10h 11m
Multiple Airlines
Sun 5/104:31 pm
TYS
- MIA
2 stops25h 26m
Multiple Airlines
Deal found 2/3![Multiple Airlines logo]()
$293
This Southwest deal was found by Cheapflights users on 2/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 4/257:00 am
MIA
- TYS
2 stops11h 30m
Southwest
Sat 5/27:45 am
TYS
- MIA
1 stop6h 40m
Southwest
Deal found 2/3![Southwest logo]()
$294
This Southwest deal was found by Cheapflights users on 2/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 4/106:40 am
MIA
- TYS
2 stops11h 30m
Southwest
Mon 4/1312:15 pm
TYS
- MIA
1 stop9h 45m
Southwest
Deal found 2/2![Southwest logo]()
$297
This American Airlines deal was found by Cheapflights users on 2/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 2/177:45 pm
EYW
- TYS
1 stop4h 14m
American Airlines
Sat 2/215:00 pm
TYS
- EYW
1 stop5h 37m
American Airlines
Deal found 2/2![American Airlines logo]()
$309
Best flights from Florida Keys to KnoxvilleDiscover carefully curated flight deals from Florida Keys to Knoxville that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated February 4, 2026.
Discover carefully curated flight deals from Florida Keys to Knoxville that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated February 4, 2026.
This Southwest deal was found by Cheapflights users on 2/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 4/257:00 am
MIA
- TYS
2 stops11h 30m
Southwest
Wed 4/297:05 am
TYS
- MIA
2 stops10h 25m
Southwest
Deal found 2/3![Southwest logo]()
$238
This Kiwi.com deal was found by Cheapflights users on 2/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 2/188:37 pm
MIA
- TYS
1 stop15h 35m
Multiple Airlines
Fri 2/207:15 am
TYS
- MIA
1 stop30h 06m
Multiple Airlines
Deal found 2/3![Multiple Airlines logo]()
$286
This American Airlines deal was found by Cheapflights users on 2/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 4/259:45 pm
MIA
- TYS
Nonstop2h 14m
American Airlines
Wed 4/296:15 am
TYS
- MIA
Nonstop2h 08m
American Airlines
Deal found 2/3![American Airlines logo]()
$289
This Delta deal was found by Cheapflights users on 2/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 6/36:00 am
MIA
- TYS
1 stop8h 33m
Delta
Wed 6/105:30 am
TYS
- MIA
1 stop10h 13m
Delta
Deal found 2/2![Delta logo]()
$305
This Kiwi.com deal was found by Cheapflights users on 2/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 2/171:01 pm
EYW
- TYS
2 stops21h 07m
Multiple Airlines
Sat 2/211:54 pm
TYS
- EYW
1 stop24h 25m
Multiple Airlines
Deal found 2/2![Multiple Airlines logo]()
$289
This Southwest deal was found by Cheapflights users on 2/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 4/106:40 am
MIA
- TYS
2 stops11h 30m
Southwest
Mon 4/1312:15 pm
TYS
- MIA
1 stop9h 45m
Southwest
Deal found 2/2![Southwest logo]()
$297
This American Airlines deal was found by Cheapflights users on 2/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 2/177:45 pm
EYW
- TYS
1 stop4h 14m
American Airlines
Sat 2/215:00 pm
TYS
- EYW
1 stop5h 37m
American Airlines
Deal found 2/2![American Airlines logo]()
$309
This Delta deal was found by Cheapflights users on 2/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 6/67:36 pm
MIA
- TYS
1 stop4h 13m
Delta
Wed 6/105:30 am
TYS
- MIA
1 stop10h 13m
Delta
Deal found 2/2![Delta logo]()
$318
This Delta deal was found by Cheapflights users on 2/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 6/36:00 am
MIA
- TYS
1 stop8h 33m
Delta
Tue 6/163:20 pm
TYS
- MIA
1 stop6h 12m
Delta
Deal found 2/2![Delta logo]()
$318
This Delta deal was found by Cheapflights users on 2/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 4/256:00 am
MIA
- TYS
1 stop5h 17m
Delta
Wed 4/294:38 pm
TYS
- MIA
1 stop4h 10m
Delta
Deal found 2/3![Delta logo]()
$325
This Delta deal was found by Cheapflights users on 2/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 7/2211:40 am
MIA
- TYS
1 stop8h 53m
Delta
Wed 7/295:30 am
TYS
- MIA
1 stop5h 30m
Delta
Deal found 2/3![Delta logo]()
$331
This Delta deal was found by Cheapflights users on 2/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 7/228:05 am
MIA
- TYS
1 stop6h 35m
Delta
Tue 7/2810:05 am
TYS
- MIA
1 stop5h 38m
Delta
Deal found 2/3![Delta logo]()
$331
Last-minute flights from Florida Keys to KnoxvilleDiscover last-minute flight deals from Florida Keys to Knoxville. Data last updated February 4, 2026 and is based on user searches.
Discover last-minute flight deals from Florida Keys to Knoxville. Data last updated February 4, 2026 and is based on user searches.
This Kiwi.com deal was found by Cheapflights users on 2/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 2/65:41 pm
EYW
- TYS
Nonstop2h 15m
Allegiant Air
Sun 2/88:30 am
TYS
- EYW
1 stop13h 07m
Allegiant Air
Deal found 2/2![Allegiant Air logo]()
$278
This American Airlines deal was found by Cheapflights users on 2/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 2/64:37 pm
EYW
- TYS
1 stop7h 22m
American Airlines
Sun 2/84:00 pm
TYS
- EYW
2 stops7h 56m
American Airlines
Deal found 2/2![American Airlines logo]()
$374
This Kiwi.com deal was found by Cheapflights users on 2/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 2/171:01 pm
EYW
- TYS
2 stops21h 07m
Multiple Airlines
Sat 2/211:54 pm
TYS
- EYW
1 stop24h 25m
Multiple Airlines
Deal found 2/2![Multiple Airlines logo]()
$289
This American Airlines deal was found by Cheapflights users on 2/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 2/177:45 pm
EYW
- TYS
1 stop4h 14m
American Airlines
Sat 2/215:00 pm
TYS
- EYW
1 stop5h 37m
American Airlines
Deal found 2/2![American Airlines logo]()
$309
This American Airlines deal was found by Cheapflights users on 2/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 2/189:43 pm
MIA
- TYS
Nonstop2h 16m
American Airlines
Sat 2/215:00 pm
TYS
- MIA
1 stop6h 43m
American Airlines
Deal found 2/3![American Airlines logo]()
$279
This Kiwi.com deal was found by Cheapflights users on 2/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 2/188:37 pm
MIA
- TYS
1 stop15h 35m
Multiple Airlines
Fri 2/207:15 am
TYS
- MIA
1 stop30h 06m
Multiple Airlines
Deal found 2/3![Multiple Airlines logo]()
$286
This American Airlines deal was found by Cheapflights users on 2/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 2/199:43 pm
MIA
- TYS
Nonstop2h 16m
American Airlines
Sun 2/225:45 am
TYS
- MIA
Nonstop2h 10m
American Airlines
Deal found 2/4![American Airlines logo]()
$269
This Kiwi.com deal was found by Cheapflights users on 2/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 2/1910:05 am
MIA
- TYS
2 stops10h 37m
Multiple Airlines
Sun 2/225:56 pm
TYS
- MIA
1 stop28h 01m
Multiple Airlines
Deal found 2/4![Multiple Airlines logo]()
$272
This American Airlines deal was found by Cheapflights users on 2/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 2/199:43 pm
MIA
- TYS
Nonstop2h 16m
American Airlines
Sun 3/226:00 am
TYS
- MIA
Nonstop2h 12m
American Airlines
Deal found 2/4![American Airlines logo]()
$316
This Kiwi.com deal was found by Cheapflights users on 2/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 2/195:05 am
MIA
- TYS
2 stops17h 05m
Multiple Airlines
Sun 3/226:00 am
TYS
- MIA
1 stop27h 34m
Multiple Airlines
Deal found 2/4![Multiple Airlines logo]()
$318
This Kiwi.com deal was found by Cheapflights users on 2/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 3/55:55 pm
MIA
- TYS
1 stop18h 05m
Multiple Airlines
Mon 3/98:54 pm
TYS
- MIA
2 stops16h 12m
Multiple Airlines
Deal found 2/2![Multiple Airlines logo]()
$220
This Southwest deal was found by Cheapflights users on 2/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 3/2512:40 pm
MIA
- TYS
1 stop8h 30m
Southwest
Sun 3/291:35 pm
TYS
- MIA
2 stops9h 25m
Southwest
Deal found 2/2![Southwest logo]()
$310
One-way flights from Florida Keys to KnoxvilleSearch for one-way flight options from Florida Keys to Knoxville. Find affordable one-way fares based on user searches. Data last updated February 4, 2026.
Search for one-way flight options from Florida Keys to Knoxville. Find affordable one-way fares based on user searches. Data last updated February 4, 2026.
This Kiwi.com deal was found by Cheapflights users on 2/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 3/41:21 pm
MIA
- TYS
1 stop22h 41m
Multiple Airlines
Deal found 2/3![Multiple Airlines logo]()
$86
This Kiwi.com deal was found by Cheapflights users on 2/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 2/198:00 am
MIA
- TYS
1 stop14h 10m
Multiple Airlines
Deal found 2/2![Multiple Airlines logo]()
$98
This Kiwi.com deal was found by Cheapflights users on 2/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 3/37:09 pm
MIA
- TYS
2 stops40h 25m
Multiple Airlines
Deal found 2/2![Multiple Airlines logo]()
$100
This Kiwi.com deal was found by Cheapflights users on 2/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 2/95:41 pm
EYW
- TYS
Nonstop2h 15m
Allegiant Air
Deal found 2/1![Allegiant Air logo]()
$101
This Kiwi.com deal was found by Cheapflights users on 2/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 3/512:52 pm
MIA
- TYS
1 stop23h 08m
Multiple Airlines
Deal found 2/3![Multiple Airlines logo]()
$102
This Southwest deal was found by Cheapflights users on 2/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 4/2912:10 pm
MIA
- TYS
1 stop7h 30m
Southwest
Deal found 2/3![Southwest logo]()
$105
This Priceline deal was found by Cheapflights users on 2/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Priceline is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 3/26:25 am
MIA
- TYS
1 stop12h 53m
Frontier
Deal found 2/3![Frontier logo]()
$107
This Southwest deal was found by Cheapflights users on 2/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 4/16:55 am
MIA
- TYS
1 stop10h 45m
Southwest
Deal found 2/2![Southwest logo]()
$110
This Kiwi.com deal was found by Cheapflights users on 2/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 2/911:04 am
EYW
- TYS
2 stops9h 32m
Multiple Airlines
Deal found 2/1![Multiple Airlines logo]()
$426
Find flight deals from Florida Keys to Knoxville
Keep the following information in mind while searching for Florida Keys to Knoxville flight deals. Data was last updated February 4, 2026.
Most accurate provider | FlightHub 3 stars |
|---|---|
Most trusted provider | FlightHub 3 stars |
Round-trip from | $220 (Kiwi.com) |
One-way from | $86 (Kiwi.com) |
Popular in | September |
Cheapest in | December |
Cheapflights Fare Finder
Customize your flight search to find flights from Florida Keys to Knoxville that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated February 4, 2026.
Use the filters below to find and compare flights from Florida Keys to Knoxville that are best for you.
Fly from
Florida Keys
Fly to
Knoxville
Route
Depart
Return
Price
MiamiKnoxville
MIA - TYS
MIATYS
Miami
Sat 4/25
7:00 am-6:30 pm
2 stops11h 30m
Knoxville McGhee Tyson
Wed 4/29
7:05 am-5:30 pm
2 stops10h 25m
$238
MiamiKnoxville
MIA - TYS
MIATYS
Miami
Wed 2/18
8:37 pm-12:12 pm
1 stop15h 35m
Knoxville McGhee Tyson
Fri 2/20
7:15 am-1:21 pm
1 stop30h 06m
$286
MiamiKnoxville
MIA - TYS
MIATYS
Miami
Sat 4/25
9:45 pm-11:59 pm
Nonstop2h 14m
Knoxville McGhee Tyson
Wed 4/29
6:15 am-8:23 am
Nonstop2h 08m
$289
Key WestKnoxville
EYW - TYS
EYWTYS
Key West
Tue 2/17
1:01 pm-10:08 am
2 stops21h 07m
Knoxville McGhee Tyson
Sat 2/21
1:54 pm-2:19 pm
1 stop24h 25m
$289
MiamiKnoxville
MIA - TYS
MIATYS
Miami
Fri 4/10
6:40 am-6:10 pm
2 stops11h 30m
Knoxville McGhee Tyson
Mon 4/13
12:15 pm-10:00 pm
1 stop9h 45m
$297
MiamiKnoxville
MIA - TYS
MIATYS
Miami
Wed 6/3
6:00 am-2:33 pm
1 stop8h 33m
Knoxville McGhee Tyson
Wed 6/10
5:30 am-3:43 pm
1 stop10h 13m
$305
Key WestKnoxville
EYW - TYS
EYWTYS
Key West
Tue 2/17
7:45 pm-11:59 pm
1 stop4h 14m
Knoxville McGhee Tyson
Sat 2/21
5:00 pm-10:37 pm
1 stop5h 37m
$309
MiamiKnoxville
MIA - TYS
MIATYS
Miami
Sat 6/6
7:36 pm-11:49 pm
1 stop4h 13m
Knoxville McGhee Tyson
Wed 6/10
5:30 am-3:43 pm
1 stop10h 13m
$318
MiamiKnoxville
MIA - TYS
MIATYS
Miami
Wed 6/3
6:00 am-2:33 pm
1 stop8h 33m
Knoxville McGhee Tyson
Tue 6/16
3:20 pm-9:32 pm
1 stop6h 12m
$318
MiamiKnoxville
MIA - TYS
MIATYS
Miami
Sat 4/25
6:00 am-11:17 am
1 stop5h 17m
Knoxville McGhee Tyson
Wed 4/29
4:38 pm-8:48 pm
1 stop4h 10m
$325
Showing 1-10 of 21 results
Best time to book a flight from Florida Keys to Knoxville
Have a flexible travel schedule? Discover the best time to fly to Knoxville from Florida Keys with our price prediction graph.
MIA-TYS
EYW-TYS
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.
Cheapflights Insights
Everything you need to know about your flight from Florida Keys to Knoxville
zzEOA-TYS
MIA-TYS
EYW-TYS
What is the cheapest month to book a flight from Florida Keys to Knoxville?
Currently, November is the cheapest month in which you can book a flight from Florida Keys to Knoxville (average of $83). Flying from Florida Keys to Knoxville in July is currently the most expensive (average of $276). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.
What is the cheapest time of day to fly from EOA to TYS?
Find hourly flight availability from Florida Keys to Knoxville. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated February 4, 2026.
Regardless of the time of day you decide to fly, the ticket price will remain around the same. Book flights from Florida Keys to Knoxville as you normally would.
Reviews of airlines servicing Knoxville
Get insights into the airlines that provide service to Knoxville. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Knoxville. Reviews last updated February 4, 2026.
See what other customers who have flown with Delta, American Airlines, and Allegiant Air from Florida Keys to Knoxville have to say. Users have also rated airlines in terms of entertainment options, comfort, food, crew/service, and boarding process.
Food
7.2
Overall
7.9
Entertainment
7.8
Crew
8.5
Boarding
8.1
Comfort
7.9
Reviews
1 / 20
6.0
Goodpilar,May 2025
RSW - ATL
Food
7.2
Overall
7.9
Entertainment
7.8
Crew
8.5
Boarding
8.1
Comfort
7.9
Reviews
1 / 20
6.0
Goodpilar,May 2025
RSW - ATL
Food
7.2
Overall
7.9
Entertainment
7.8
Crew
8.5
Boarding
8.1
Comfort
7.9
Reviews
1 / 20
6.0
Goodpilar,May 2025
RSW - ATL
Food
7.2
Overall
7.9
Entertainment
7.8
Crew
8.5
Boarding
8.1
Comfort
7.9
Reviews
1 / 20
6.0
Goodpilar,May 2025
RSW - ATL
Related info for your journey
Find useful and relevant information for your journey from Florida Keys to Knoxville. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.
Traveling to a place near Knoxville?
Book flights to Knoxville if you plan to visit one of these locationsCherokee
Crossville
Corbin
Morristown
Bryson City
Alcoa
Oak Ridge
Murphy
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Alternative routes for Florida Keys to Knoxville
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Complete your trip
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Search flights from Florida Keys to Knoxville by cabin class
Find flights from Florida Keys to Knoxville, based on your preferred cabin class, be it economy, premium economy, business, or first class.
Other flights to Knoxville
Explore flights to Knoxville departing from other origins. Flights are based on user searches made on Cheapflights and were last updated on February 4, 2026.
Florida Keys and Knoxville flights
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Florida Keys to Knoxville flights
Consider these flights traveling from Florida Keys to Knoxville.
Top 2 airlines flying from Florida Keys to Knoxville
Discover the top 2 airlines that operate flights from Florida Keys to Knoxville. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated February 4, 2026.
| Airline | Cheapest | Average | Flexibility | On-time |
|---|---|---|---|---|
| Cheapest$273 | Average$498 | FlexibilityNo cancel fee | On-timeN/A | |
| Cheapest$298 | Average$389 | FlexibilityNo cancel fee | On-time71% |