HomeSearch by dateVacation packagesHotelsFlight dealsCar rentalTravel tips & news
Knoxville

$82+ Cheap flights from Florida Keys to Knoxville (TYS)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 1/15. Fares are subject to change and may not be available on all flights or dates of travel.
EYW — TYS
Jan 17 — Jan 241
Sat 1/17
Sat 1/24
1 adult, Economy
We work with more than 300 partners to bring you better travel deals

Find cheap flights from Florida Keys to Knoxville with Cheapflights

1. Tell us where you want to go

Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”

2. Select your favorite providers

We find the providers serving your travel needs. Choose up to four travel providers to compare side-by-side for flights, hotels, or car rentals.

3. Compare prices and book

Review each provider’s pricing and select the best option for you! Book through your favorite provider’s website for a seamless experience.

Cheap flight deals from Florida Keys to Knoxville

Cheapest flights from Florida Keys to Knoxville
Explore the most affordable flight options available from Florida Keys to Knoxville. Find the lowest fares from popular airlines and budget airlines, with prices last updated on December 18, 2025.

This Kiwi.com deal was found by Cheapflights users on 12/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 12/277:30 amMIA - TYS
1 stop11h 07mMultiple Airlines
Wed 12/3112:01 pmTYS - MIA
2 stops33h 03mMultiple Airlines
Deal found 12/16$288
This Kiwi.com deal was found by Cheapflights users on 12/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/315:30 amMIA - TYS
2 stops10h 45mMultiple Airlines
Sat 1/37:15 amTYS - MIA
1 stop26h 20mMultiple Airlines
Deal found 12/16$325
This Kiwi.com deal was found by Cheapflights users on 12/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 12/309:59 pmMIA - TYS
2 stops18h 16mMultiple Airlines
Fri 1/27:15 amTYS - MIA
1 stop10h 39mMultiple Airlines
Deal found 12/16$365
This Kiwi.com deal was found by Cheapflights users on 12/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 12/277:30 amMIA - TYS
1 stop11h 07mMultiple Airlines
Fri 1/26:00 amTYS - MIA
2 stops31h 06mMultiple Airlines
Deal found 12/17$385
This American Airlines deal was found by Cheapflights users on 12/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 12/162:14 pmMIA - TYS
Nonstop2h 19mAmerican Airlines
Tue 12/237:01 pmTYS - MIA
Nonstop2h 12mAmerican Airlines
Deal found 12/15$455
This Kiwi.com deal was found by Cheapflights users on 12/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 12/295:30 amMIA - TYS
2 stops26h 48mMultiple Airlines
Fri 1/27:15 amTYS - MIA
1 stop10h 39mMultiple Airlines
Deal found 12/17$464
This Orbitz deal was found by Cheapflights users on 12/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Orbitz is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/186:05 amMIA - TYS
1 stop9h 26mFrontier
Mon 12/224:46 pmTYS - MIA
1 stop12h 14mFrontier
Deal found 12/16$472
This Delta deal was found by Cheapflights users on 12/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 12/1612:36 pmMIA - TYS
1 stop6h 22mDelta
Tue 12/2310:02 amTYS - MIA
1 stop5h 52mDelta
Deal found 12/15$475
This American Airlines deal was found by Cheapflights users on 12/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 12/214:40 pmEYW - TYS
1 stop5h 18mAmerican Airlines
Fri 12/2610:09 amTYS - EYW
2 stops9h 13mAmerican Airlines
Deal found 12/17$1,044

Find flight deals from Florida Keys to Knoxville

Keep the following information in mind while searching for Florida Keys to Knoxville flight deals. Data was last updated December 18, 2025.

Most accurate provider

eDreams
3 stars

Most trusted provider

eDreams
3 stars

Round-trip from

$153
(Kiwi.com)

One-way from

$82
(Kiwi.com)

Popular in

December

Cheapest in

October

Average price

$621
Provider with most accurate pricing for Key West-Knoxville McGhee Tyson flight deals.
Search Deals
Provider most trusted by Cheapflights users for Key West-Knoxville McGhee Tyson flights.
Search Deals
From Florida Keys to Knoxville McGhee Tyson
Search Deals
One-way flight from Florida Keys to Knoxville McGhee Tyson
Search Deals
Highest demand for flights based on searches. 1% potential increase in price ($4 potential increase over avg. RT price).
Search Deals
Cheapest flight prices on average. 6% potential price decrease ($23 potential savings vs. average RT price).
Search Deals
Average for round-trip flights in December 2025
Search Deals

Cheapflights Fare Finder

 
Customize your flight search to find flights from Florida Keys to Knoxville that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated December 18, 2025.
Use the filters below to find and compare flights from Florida Keys to Knoxville that are best for you.

Fly from

Florida Keys

Fly to

Knoxville

Route

Depart

Return

Price

MiamiKnoxville

MIA - TYS

MIATYS

Miami

Fri 2/6

2:37 pm-5:06 pm

Nonstop2h 29m

Knoxville McGhee Tyson

Sun 2/8

6:20 am-8:38 am

Nonstop2h 18m

$180

MiamiKnoxville

MIA - TYS

MIATYS

Miami

Wed 1/28

2:57 pm-8:39 am

2 stops17h 42m

Knoxville McGhee Tyson

Sun 2/1

1:39 pm-6:50 pm

1 stop29h 11m

$197

MiamiKnoxville

MIA - TYS

MIATYS

Miami

Thu 1/8

6:20 pm-11:45 pm

1 stop5h 25m

Knoxville McGhee Tyson

Mon 1/12

6:09 pm-10:48 pm

1 stop4h 39m

$219

MiamiKnoxville

MIA - TYS

MIATYS

Miami

Thu 1/8

6:20 pm-11:45 pm

1 stop5h 25m

Knoxville McGhee Tyson

Tue 1/13

5:40 am-12:14 pm

1 stop6h 34m

$219

MiamiKnoxville

MIA - TYS

MIATYS

Miami

Thu 1/8

6:20 pm-11:45 pm

1 stop5h 25m

Knoxville McGhee Tyson

Sun 1/11

5:40 am-10:40 am

1 stop5h 00m

$219

MiamiKnoxville

MIA - TYS

MIATYS

Miami

Thu 2/19

9:33 pm-11:55 pm

Nonstop2h 22m

Knoxville McGhee Tyson

Mon 2/23

2:50 pm-8:55 pm

1 stop6h 05m

$234

MiamiKnoxville

MIA - TYS

MIATYS

Miami

Wed 2/18

6:00 am-11:08 am

1 stop5h 08m

Knoxville McGhee Tyson

Sat 2/21

5:30 am-9:26 am

1 stop3h 56m

$239

MiamiKnoxville

MIA - TYS

MIATYS

Miami

Wed 1/28

8:15 am-1:50 pm

1 stop5h 35m

Knoxville McGhee Tyson

Sun 2/1

2:37 pm-8:44 pm

1 stop6h 07m

$249

MiamiKnoxville

MIA - TYS

MIATYS

Miami

Wed 1/14

10:29 am-3:19 pm

1 stop4h 50m

Knoxville McGhee Tyson

Tue 1/20

5:40 am-9:24 am

1 stop3h 44m

$249

Key WestKnoxville

EYW - TYS

EYWTYS

Key West

Sat 1/3

10:35 pm-9:24 pm

1 stop22h 49m

Knoxville McGhee Tyson

Mon 1/5

12:58 pm-9:11 pm

1 stop8h 13m

$259

Flights are sorted by cheapest round-trip flights first.

Deals found on 12/17

Showing 1-10 of 24 results
1
2
3

Best time to book a flight from Florida Keys to Knoxville

Have a flexible travel schedule? Discover the best time to fly to Knoxville from Florida Keys with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Florida Keys to Knoxville

What is the cheapest month to book a flight from Florida Keys to Knoxville?

Currently, November is the cheapest month in which you can book a flight from Florida Keys to Knoxville (average of $83). Flying from Florida Keys to Knoxville in July is currently the most expensive (average of $276). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from EOA to TYS?

Find hourly flight availability from Florida Keys to Knoxville. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated December 18, 2025.

It’s typically best to fly out from Florida Keys to Knoxville at noon. Doing so could potentially save you 75% on the flight price compared to flying in the evening, which is usually more expensive.

Reviews of airlines servicing Knoxville

Get insights into the airlines that provide service to Knoxville. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Knoxville. Reviews last updated December 18, 2025.
See what other customers who have flown with Delta, American Airlines, and Allegiant Air from Florida Keys to Knoxville have to say. Users have also rated airlines in terms of entertainment options, comfort, food, crew/service, and boarding process.
Delta
7.9
Good
8,008 reviews

Comfort

7.9

Boarding

8.1

Food

7.3

Overall

7.9

Entertainment

7.9

Crew

8.5

Reviews

1 / 20
6.0
Good

pilar,May 2025

RSW - ATL

The stewardess was not very nice because I requested two glasses of water. She didn’t even offer the snacks to me. She seemed angry and I felt very bad about her reaction. Also, the flight was full and you could not move. The airline should provide seats for obese people in consideration to the rest pf the passengers.
Delta
7.9
Good
8,008 reviews
Delta
7.9
Good
8,008 reviews

Comfort

7.9

Boarding

8.1

Food

7.3

Overall

7.9

Entertainment

7.9

Crew

8.5

Reviews

1 / 20
6.0
Good

pilar,May 2025

RSW - ATL

The stewardess was not very nice because I requested two glasses of water. She didn’t even offer the snacks to me. She seemed angry and I felt very bad about her reaction. Also, the flight was full and you could not move. The airline should provide seats for obese people in consideration to the rest pf the passengers.
American Airlines
7.2
Good
11,055 reviews
Delta
7.9
Good
8,008 reviews

Comfort

7.9

Boarding

8.1

Food

7.3

Overall

7.9

Entertainment

7.9

Crew

8.5

Reviews

1 / 20
6.0
Good

pilar,May 2025

RSW - ATL

The stewardess was not very nice because I requested two glasses of water. She didn’t even offer the snacks to me. She seemed angry and I felt very bad about her reaction. Also, the flight was full and you could not move. The airline should provide seats for obese people in consideration to the rest pf the passengers.
Allegiant Air
7.2
Good
700 reviews
Delta
7.9
Good
8,008 reviews

Comfort

7.9

Boarding

8.1

Food

7.3

Overall

7.9

Entertainment

7.9

Crew

8.5

Reviews

1 / 20
6.0
Good

pilar,May 2025

RSW - ATL

The stewardess was not very nice because I requested two glasses of water. She didn’t even offer the snacks to me. She seemed angry and I felt very bad about her reaction. Also, the flight was full and you could not move. The airline should provide seats for obese people in consideration to the rest pf the passengers.

Related info for your journey

Find useful and relevant information for your journey from Florida Keys to Knoxville. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airport do you fly into for flights to Knoxville from Florida Keys?

    Located just 11.3 mi from the city center, Knoxville McGhee Tyson (TYS) is the airport most travelers will use when flying to Knoxville from Florida Keys.

  • How long is the flight from Florida Keys to Knoxville?

    American Airlines, Delta, and Allegiant Air can get you from Florida Keys to Knoxville in just under 2h 29m. Your travel time can differ by up to 20h 20m. The distance between Florida Keys and Knoxville is about 725 mi. Both multi-stop and nonstop flights can be found to your destination and back.

  • What are the cheapest airlines to fly from Florida Keys to Knoxville one-way?

    For one-way options, check prices for Allegiant Air. According to our data, you can fly for as low as $41. Users have also found prices from $89 and $99 on Delta and American Airlines, respectively.

  • What are the cheapest flights from Florida Keys to Knoxville?

    While on average a flight from Florida Keys to Knoxville is generally $88, our data shows the cheapest flight currently is $45. When looking at the most popular route, (Miami - Knoxville McGhee Tyson), you can expect to pay $153 for that flight.

  • Can I find deals for flights from Florida Keys to Knoxville that include hotel bookings?

    Yes. In addition to deals on Florida Keys to Knoxville flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Florida Keys to Knoxville?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Florida Keys to Knoxville.

  • Can I find deals for business class flights from Florida Keys to Knoxville?

    Yes. Cheapflights offers flight deals from Florida Keys to Knoxville by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Florida Keys to Knoxville?

    Currently, November is the cheapest month in which you can book a flight from Florida Keys to Knoxville (average of $83). Flying from Florida Keys to Knoxville in July is currently the most expensive (average of $276). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Traveling to a place near Knoxville?

Book flights to Knoxville if you plan to visit one of these locations
Cherokee
Crossville
Corbin
Morristown
Bryson City
Alcoa
Oak Ridge
Murphy

Browse thousands of different options on Cheapflights for your next trip

Toggle through the tabs below to find thousands of options on Cheapflights for your next trip.

Alternative routes for Florida Keys to Knoxville

See prices for flight routes from nearby airports that may be better suited for you.
Tampa to Nashville flights
Orlando to Nashville flights
Fort Lauderdale to Nashville flights
Miami to Nashville flights
Jacksonville to Nashville flights
West Palm Beach to Nashville flights
Fort Lauderdale to Knoxville flights
Orlando to Memphis flights
Orlando Sanford Intl to Knoxville flights
Fort Myers to Nashville flights
Tampa to Knoxville flights
Miami to Knoxville flights
Orlando to Knoxville flights
Sarasota to Nashville flights
Fort Myers to Knoxville flights
Miami to Memphis flights
Sarasota to Knoxville flights
Orlando to Chattanooga flights
Tampa to Memphis flights
Pensacola to Nashville flights
Jacksonville to Knoxville flights
St Petersburg to Knoxville flights
Jacksonville to Memphis flights
Jacksonville to Chattanooga flights
Tampa to Chattanooga flights
Fort Lauderdale to Chattanooga flights
Pensacola to Knoxville flights
Panama City to Nashville flights
Gainesville to Nashville flights
West Palm Beach to Knoxville flights
Daytona Beach to Knoxville flights
Sarasota to Memphis flights
Fort Lauderdale to Memphis flights
Tallahassee to Nashville flights
Miami to Chattanooga flights
Tampa to Blountville flights
Daytona Beach to Nashville flights
Orlando to Blountville flights
Melbourne to Nashville flights
Pensacola to Chattanooga flights
Fort Myers to Memphis flights
Valparaiso to Nashville flights
West Palm Beach to Chattanooga flights
Sarasota to Chattanooga flights
West Palm Beach to Memphis flights
Punta Gorda to Nashville flights
Panama City to Knoxville flights
Fort Myers to Chattanooga flights
Tallahassee to Knoxville flights
Pensacola to Memphis flights

Top 2 airlines flying from Florida Keys to Knoxville

Discover the top 2 airlines that operate flights from Florida Keys to Knoxville. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated December 18, 2025.
AirlineCheapestAverageFlexibilityOn-time
DeltaCheapest$253Average$498FlexibilityNo cancel feeOn-timeN/A
American AirlinesCheapest$298Average$398FlexibilityNo cancel feeOn-time71%

100% Free

Cheapflights is completely free to use, so you can start saving the moment you arrive.

Book with Flexibility

Our users can plan ahead with confidence and find flights with no change fees

Travel Smart

Millions of people come to us for their flight needs every year. We help make travel planning easy by providing useful insights and data-driven graphs that can inform your decisions.