$71+ Cheap flights from Knoxville (TYS) to Florida Keys
This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 10/23. Fares are subject to change and may not be available on all flights or dates of travel.
TYS — EYW
Jun 21 — Jun 281
Round-trip
1 adult, Economy
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Find cheap flights from Knoxville to Florida Keys with Cheapflights
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Cheapest flights from Knoxville to Florida KeysExplore the most affordable flight options available from Knoxville to Florida Keys. Find the lowest fares from popular airlines and budget airlines, with prices last updated on May 22, 2026.
Explore the most affordable flight options available from Knoxville to Florida Keys. Find the lowest fares from popular airlines and budget airlines, with prices last updated on May 22, 2026.
This Kiwi.com deal was found by Cheapflights users on 5/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 6/227:30 am
TYS
- EYW
Nonstop2h 11m
Allegiant Air
Fri 6/2610:31 am
EYW
- TYS
Nonstop2h 15m
Allegiant Air
Deal found 5/18![Allegiant Air logo]()
$72
This Super.com deal was found by Cheapflights users on 5/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Super.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 6/86:00 am
TYS
- EYW
Nonstop2h 11m
Allegiant Air
Fri 6/1210:31 am
EYW
- TYS
Nonstop2h 15m
Allegiant Air
Deal found 5/18![Allegiant Air logo]()
$79
This Kiwi.com deal was found by Cheapflights users on 5/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 7/177:30 am
TYS
- EYW
Nonstop2h 11m
Allegiant Air
Fri 7/3110:31 am
EYW
- TYS
Nonstop2h 15m
Allegiant Air
Deal found 5/21![Allegiant Air logo]()
$83
This Mytrip deal was found by Cheapflights users on 5/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 7/137:30 am
TYS
- EYW
Nonstop2h 11m
Allegiant Air
Fri 7/1710:31 am
EYW
- TYS
Nonstop2h 15m
Allegiant Air
Deal found 5/18![Allegiant Air logo]()
$96
This Kiwi.com deal was found by Cheapflights users on 5/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 6/227:30 am
TYS
- EYW
Nonstop2h 11m
Allegiant Air
Mon 6/2910:31 am
EYW
- TYS
Nonstop2h 15m
Allegiant Air
Deal found 5/21![Allegiant Air logo]()
$99
This Super.com deal was found by Cheapflights users on 5/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Super.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 6/157:30 am
TYS
- EYW
Nonstop2h 11m
Allegiant Air
Mon 6/2210:31 am
EYW
- TYS
Nonstop2h 15m
Allegiant Air
Deal found 5/18![Allegiant Air logo]()
$102
This Kiwi.com deal was found by Cheapflights users on 5/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 6/197:30 am
TYS
- EYW
Nonstop2h 11m
Allegiant Air
Fri 6/2610:31 am
EYW
- TYS
Nonstop2h 15m
Allegiant Air
Deal found 5/21![Allegiant Air logo]()
$103
This Kiwi.com deal was found by Cheapflights users on 5/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 6/197:30 am
TYS
- EYW
Nonstop2h 11m
Allegiant Air
Mon 6/2910:31 am
EYW
- TYS
Nonstop2h 15m
Allegiant Air
Deal found 5/21![Allegiant Air logo]()
$110
This Super.com deal was found by Cheapflights users on 5/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Super.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 6/157:30 am
TYS
- EYW
Nonstop2h 11m
Allegiant Air
Fri 6/1910:31 am
EYW
- TYS
Nonstop2h 15m
Allegiant Air
Deal found 5/18![Allegiant Air logo]()
$122
This Kiwi.com deal was found by Cheapflights users on 5/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 7/269:11 pm
TYS
- MIA
2 stops16h 42m
Multiple Airlines
Thu 7/303:39 pm
MIA
- TYS
1 stop25h 03m
Multiple Airlines
Deal found 5/17![Multiple Airlines logo]()
$256
This Kiwi.com deal was found by Cheapflights users on 5/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 5/313:46 pm
TYS
- MIA
1 stop28h 42m
Multiple Airlines
Mon 6/85:05 am
MIA
- TYS
2 stops18h 34m
Multiple Airlines
Deal found 5/18![Multiple Airlines logo]()
$267
This Frontier deal was found by Cheapflights users on 5/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Frontier is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 6/158:32 pm
TYS
- MIA
1 stop9h 22m
Frontier
Fri 6/196:00 am
MIA
- TYS
1 stop13h 37m
Frontier
Deal found 5/18![Frontier logo]()
$278
Best flights from Knoxville to Florida KeysDiscover carefully curated flight deals from Knoxville to Florida Keys that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated May 22, 2026.
Discover carefully curated flight deals from Knoxville to Florida Keys that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated May 22, 2026.
This Kiwi.com deal was found by Cheapflights users on 5/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 7/96:08 pm
TYS
- EYW
1 stop21h 43m
Allegiant Air
Mon 7/1310:31 am
EYW
- TYS
Nonstop2h 15m
Allegiant Air
Deal found 5/17![Allegiant Air logo]()
$191
This Kiwi.com deal was found by Cheapflights users on 5/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 8/147:30 am
TYS
- EYW
Nonstop2h 11m
Multiple Airlines
Wed 8/1911:46 am
EYW
- TYS
3 stops28h 39m
Multiple Airlines
Deal found 5/17![Multiple Airlines logo]()
$263
This Delta deal was found by Cheapflights users on 5/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 7/245:40 am
TYS
- EYW
1 stop5h 20m
Delta
Mon 7/277:50 am
EYW
- TYS
1 stop6h 58m
Delta
Deal found 5/18![Delta logo]()
$309
This American Airlines deal was found by Cheapflights users on 5/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 6/246:00 am
TYS
- EYW
1 stop7h 07m
American Airlines
Mon 6/297:29 pm
EYW
- TYS
1 stop4h 18m
American Airlines
Deal found 5/20![American Airlines logo]()
$309
This Southwest deal was found by Cheapflights users on 5/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 7/18:10 am
TYS
- MIA
1 stop6h 15m
Southwest
Tue 7/2811:25 am
MIA
- TYS
2 stops9h 50m
Southwest
Deal found 5/17![Southwest logo]()
$312
This Kiwi.com deal was found by Cheapflights users on 5/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 6/157:30 am
TYS
- EYW
Nonstop2h 11m
Allegiant Air
Thu 6/1810:56 am
EYW
- TYS
2 stops12h 28m
Allegiant Air
Deal found 5/20![Allegiant Air logo]()
$266
This American Airlines deal was found by Cheapflights users on 5/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 8/256:15 am
TYS
- EYW
2 stops6h 50m
American Airlines
Sat 8/291:41 pm
EYW
- TYS
1 stop5h 42m
American Airlines
Deal found 5/21![American Airlines logo]()
$314
This Southwest deal was found by Cheapflights users on 5/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 10/197:10 am
TYS
- MIA
2 stops11h 15m
Southwest
Thu 10/224:55 pm
MIA
- TYS
1 stop4h 05m
Southwest
Deal found 5/19![Southwest logo]()
$338
This Delta deal was found by Cheapflights users on 5/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/1612:00 pm
TYS
- EYW
1 stop5h 11m
Delta
Mon 10/192:35 pm
EYW
- TYS
1 stop6h 05m
Delta
Deal found 5/19![Delta logo]()
$364
This Kiwi.com deal was found by Cheapflights users on 5/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 10/41:37 pm
TYS
- EYW
2 stops20h 42m
Multiple Airlines
Fri 10/94:21 pm
EYW
- TYS
1 stop4h 50m
Multiple Airlines
Deal found 5/22![Multiple Airlines logo]()
$371
This Southwest deal was found by Cheapflights users on 5/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 8/2112:30 pm
TYS
- MIA
2 stops8h 15m
Southwest
Thu 8/2711:45 am
MIA
- TYS
1 stop6h 50m
Southwest
Deal found 5/21![Southwest logo]()
$341
This Delta deal was found by Cheapflights users on 5/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 6/233:54 pm
TYS
- EYW
1 stop3h 59m
Delta
Tue 6/307:50 am
EYW
- TYS
1 stop5h 29m
Delta
Deal found 5/21![Delta logo]()
$369
This Southwest deal was found by Cheapflights users on 5/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 7/306:40 am
TYS
- MIA
2 stops8h 40m
Southwest
Thu 8/612:50 pm
MIA
- TYS
1 stop7h 05m
Southwest
Deal found 5/21![Southwest logo]()
$350
This Southwest deal was found by Cheapflights users on 5/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 11/27:05 am
TYS
- MIA
1 stop7h 30m
Southwest
Fri 11/131:20 pm
MIA
- TYS
1 stop8h 20m
Southwest
Deal found 5/18![Southwest logo]()
$356
This Southwest deal was found by Cheapflights users on 5/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 8/217:10 am
TYS
- MIA
1 stop4h 40m
Southwest
Sat 8/227:00 am
MIA
- TYS
2 stops10h 40m
Southwest
Deal found 5/17![Southwest logo]()
$356
This Southwest deal was found by Cheapflights users on 5/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 6/297:30 am
TYS
- MIA
1 stop6h 50m
Southwest
Fri 7/36:20 am
MIA
- TYS
2 stops9h 25m
Southwest
Deal found 5/21![Southwest logo]()
$362
This Southwest deal was found by Cheapflights users on 5/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 8/217:10 am
TYS
- MIA
1 stop4h 40m
Southwest
Sun 8/2310:00 am
MIA
- TYS
1 stop10h 45m
Southwest
Deal found 5/17![Southwest logo]()
$362
This Southwest deal was found by Cheapflights users on 5/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 7/1612:35 pm
TYS
- MIA
1 stop9h 30m
Southwest
Mon 7/207:15 am
MIA
- TYS
2 stops14h 00m
Southwest
Deal found 5/21![Southwest logo]()
$373
Last-minute flights from Knoxville to Florida KeysDiscover last-minute flight deals from Knoxville to Florida Keys. Data last updated May 22, 2026 and is based on user searches.
Discover last-minute flight deals from Knoxville to Florida Keys. Data last updated May 22, 2026 and is based on user searches.
This Kiwi.com deal was found by Cheapflights users on 5/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 5/313:46 pm
TYS
- MIA
1 stop28h 42m
Multiple Airlines
Mon 6/85:05 am
MIA
- TYS
2 stops18h 34m
Multiple Airlines
Deal found 5/18![Multiple Airlines logo]()
$267
This Kiwi.com deal was found by Cheapflights users on 5/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 6/17:30 am
TYS
- EYW
Nonstop2h 11m
Allegiant Air
Fri 6/59:01 am
EYW
- TYS
Nonstop2h 15m
Allegiant Air
Deal found 5/18![Allegiant Air logo]()
$139
This Super.com deal was found by Cheapflights users on 5/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Super.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 6/86:00 am
TYS
- EYW
Nonstop2h 11m
Allegiant Air
Fri 6/1210:31 am
EYW
- TYS
Nonstop2h 15m
Allegiant Air
Deal found 5/18![Allegiant Air logo]()
$79
This Super.com deal was found by Cheapflights users on 5/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Super.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 6/157:30 am
TYS
- EYW
Nonstop2h 11m
Allegiant Air
Mon 6/2210:31 am
EYW
- TYS
Nonstop2h 15m
Allegiant Air
Deal found 5/18![Allegiant Air logo]()
$102
This Super.com deal was found by Cheapflights users on 5/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Super.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 6/157:30 am
TYS
- EYW
Nonstop2h 11m
Allegiant Air
Fri 6/1910:31 am
EYW
- TYS
Nonstop2h 15m
Allegiant Air
Deal found 5/18![Allegiant Air logo]()
$122
This Frontier deal was found by Cheapflights users on 5/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Frontier is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 6/158:32 pm
TYS
- MIA
1 stop9h 22m
Frontier
Fri 6/196:00 am
MIA
- TYS
1 stop13h 37m
Frontier
Deal found 5/18![Frontier logo]()
$278
This Expedia deal was found by Cheapflights users on 5/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Expedia is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 6/158:32 pm
TYS
- MIA
1 stop9h 22m
Frontier
Mon 6/226:00 am
MIA
- TYS
1 stop13h 37m
Frontier
Deal found 5/18![Frontier logo]()
$299
This Kiwi.com deal was found by Cheapflights users on 5/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 6/197:30 am
TYS
- EYW
Nonstop2h 11m
Allegiant Air
Fri 6/2610:31 am
EYW
- TYS
Nonstop2h 15m
Allegiant Air
Deal found 5/21![Allegiant Air logo]()
$103
This Kiwi.com deal was found by Cheapflights users on 5/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 6/197:30 am
TYS
- EYW
Nonstop2h 11m
Allegiant Air
Mon 6/2910:31 am
EYW
- TYS
Nonstop2h 15m
Allegiant Air
Deal found 5/21![Allegiant Air logo]()
$110
This Kiwi.com deal was found by Cheapflights users on 5/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 6/197:30 am
TYS
- EYW
Nonstop2h 11m
Allegiant Air
Mon 6/2210:31 am
EYW
- TYS
Nonstop2h 15m
Allegiant Air
Deal found 5/18![Allegiant Air logo]()
$126
This Kiwi.com deal was found by Cheapflights users on 5/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 6/227:30 am
TYS
- EYW
Nonstop2h 11m
Allegiant Air
Fri 6/2610:31 am
EYW
- TYS
Nonstop2h 15m
Allegiant Air
Deal found 5/18![Allegiant Air logo]()
$72
This Kiwi.com deal was found by Cheapflights users on 5/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 6/227:30 am
TYS
- EYW
Nonstop2h 11m
Allegiant Air
Mon 6/2910:31 am
EYW
- TYS
Nonstop2h 15m
Allegiant Air
Deal found 5/21![Allegiant Air logo]()
$99
One-way flights from Knoxville to Florida KeysSearch for one-way flight options from Knoxville to Florida Keys. Find affordable one-way fares based on user searches. Data last updated May 22, 2026.
Search for one-way flight options from Knoxville to Florida Keys. Find affordable one-way fares based on user searches. Data last updated May 22, 2026.
This Justfly.com deal was found by Cheapflights users on 5/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Justfly.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/237:00 am
TYS
- EYW
Nonstop2h 04m
Allegiant Air
Deal found 5/18![Allegiant Air logo]()
$71
This Kiwi.com deal was found by Cheapflights users on 5/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 8/1012:50 pm
TYS
- MIA
2 stops27h 43m
Multiple Airlines
Deal found 5/17![Multiple Airlines logo]()
$107
This Kiwi.com deal was found by Cheapflights users on 5/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 7/1312:40 pm
TYS
- MIA
2 stops27h 53m
Multiple Airlines
Deal found 5/20![Multiple Airlines logo]()
$108
This Frontier deal was found by Cheapflights users on 5/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Frontier is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 8/108:32 pm
TYS
- MIA
1 stop9h 19m
Frontier
Deal found 5/17![Frontier logo]()
$109
This Frontier deal was found by Cheapflights users on 5/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Frontier is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 6/158:32 pm
TYS
- MIA
1 stop9h 22m
Frontier
Deal found 5/18![Frontier logo]()
$114
This Kiwi.com deal was found by Cheapflights users on 5/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 6/1212:40 pm
TYS
- MIA
2 stops31h 55m
Multiple Airlines
Deal found 5/18![Multiple Airlines logo]()
$115
This Kiwi.com deal was found by Cheapflights users on 5/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 6/1512:49 pm
TYS
- MIA
2 stops27h 42m
Multiple Airlines
Deal found 5/17![Multiple Airlines logo]()
$116
This Trip.com deal was found by Cheapflights users on 5/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Trip.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 6/178:00 am
TYS
- EYW
1 stop8h 17m
Allegiant Air
Deal found 5/18![Allegiant Air logo]()
$116
This Kiwi.com deal was found by Cheapflights users on 5/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 6/113:42 pm
TYS
- EYW
1 stop22h 53m
Allegiant Air
Deal found 5/20![Allegiant Air logo]()
$122
This Kiwi.com deal was found by Cheapflights users on 5/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 7/1712:40 pm
TYS
- MIA
2 stops31h 49m
Multiple Airlines
Deal found 5/21![Multiple Airlines logo]()
$123
This Kiwi.com deal was found by Cheapflights users on 5/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 8/176:29 pm
TYS
- MIA
2 stops28h 34m
Multiple Airlines
Deal found 5/18![Multiple Airlines logo]()
$124
This Kiwi.com deal was found by Cheapflights users on 5/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 6/25:05 pm
TYS
- MIA
2 stops20h 15m
Multiple Airlines
Deal found 5/17![Multiple Airlines logo]()
$128
Find flight deals from Knoxville to Florida Keys
Keep the following information in mind while searching for Knoxville to Florida Keys flight deals. Data was last updated May 22, 2026.
Most accurate provider | FlightHub 3 stars |
|---|---|
Most trusted provider | FlightHub 3 stars |
Round-trip from | $72 (Kiwi.com) |
One-way from | $71 (Justfly.com) |
Popular in | March |
Cheapest in | February |
Average price | $439 |
Cheapflights Fare Finder
Customize your flight search to find flights from Knoxville to Florida Keys that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated May 22, 2026.
Use the filters below to find and compare flights from Knoxville to Florida Keys that are best for you.
Fly from
Fly to
Route
Depart
Return
Cheapest round-trip
KnoxvilleKey West
TYS - EYW
TYSEYW
Knoxville McGhee Tyson
Thu 7/9
6:08 pm-3:51 pm
1 stop21h 43m
Key West
Mon 7/13
10:31 am-12:46 pm
Nonstop2h 15m
$191
KnoxvilleKey West
TYS - EYW
TYSEYW
Knoxville McGhee Tyson
Fri 8/14
7:30 am-9:41 am
Nonstop2h 11m
Key West
Wed 8/19
11:46 am-4:25 pm
3 stops28h 39m
$263
KnoxvilleKey West
TYS - EYW
TYSEYW
Knoxville McGhee Tyson
Mon 6/15
7:30 am-9:41 am
Nonstop2h 11m
Key West
Thu 6/18
10:56 am-11:24 pm
2 stops12h 28m
$266
KnoxvilleKey West
TYS - EYW
TYSEYW
Knoxville McGhee Tyson
Fri 7/24
5:40 am-11:00 am
1 stop5h 20m
Key West
Mon 7/27
7:50 am-2:48 pm
1 stop6h 58m
$309
KnoxvilleKey West
TYS - EYW
TYSEYW
Knoxville McGhee Tyson
Wed 6/24
6:00 am-1:07 pm
1 stop7h 07m
Key West
Mon 6/29
7:29 pm-11:47 pm
1 stop4h 18m
$309
KnoxvilleMiami
TYS - MIA
TYSMIA
Knoxville McGhee Tyson
Wed 7/1
8:10 am-2:25 pm
1 stop6h 15m
Miami
Tue 7/28
11:25 am-9:15 pm
2 stops9h 50m
$312
KnoxvilleKey West
TYS - EYW
TYSEYW
Knoxville McGhee Tyson
Tue 8/25
6:15 am-1:05 pm
2 stops6h 50m
Key West
Sat 8/29
1:41 pm-7:23 pm
1 stop5h 42m
$314
KnoxvilleMiami
TYS - MIA
TYSMIA
Knoxville McGhee Tyson
Mon 10/19
7:10 am-6:25 pm
2 stops11h 15m
Miami
Thu 10/22
4:55 pm-9:00 pm
1 stop4h 05m
$338
KnoxvilleMiami
TYS - MIA
TYSMIA
Knoxville McGhee Tyson
Fri 8/21
12:30 pm-8:45 pm
2 stops8h 15m
Miami
Thu 8/27
11:45 am-6:35 pm
1 stop6h 50m
$341
KnoxvilleMiami
TYS - MIA
TYSMIA
Knoxville McGhee Tyson
Thu 7/30
6:40 am-3:20 pm
2 stops8h 40m
Miami
Thu 8/6
12:50 pm-7:55 pm
1 stop7h 05m
$350
Showing 1-10 of 35 resultsSorted by cheapest first
Best time to book a flight from Knoxville to Florida Keys
Have a flexible travel schedule? Discover the best time to fly to Florida Keys from Knoxville with our price prediction graph.
TYS-EYW
TYS-MIA
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.
Cheapflights Insights
Everything you need to know about your flight from Knoxville to Florida Keys
TYS-zzEOA
TYS-EYW
TYS-MIA
What is the cheapest month to book a flight from Knoxville to Florida Keys?
Currently, January is the cheapest month in which you can book a flight from Knoxville to Florida Keys (average of $46). Flying from Knoxville to Florida Keys in April is currently the most expensive (average of $116). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.
What is the cheapest time of day to fly from TYS to EOA?
Find hourly flight availability from Knoxville to Florida Keys. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated May 22, 2026.
Regardless of the time of day you decide to fly, the ticket price will remain around the same. Book flights from Knoxville to Florida Keys as you normally would.
How far ahead should I book a flight from Knoxville to Florida Keys?
To ensure you get the cheapest price possible for a flight from Knoxville to Florida Keys, you should look to book at least 68 days in advance of your intended travel date. The price of your flight may increase if you delay and leave booking until a week or so before departure.
Reviews of airlines servicing Florida Keys
Get insights into the airlines that provide service to Florida Keys. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Florida Keys. Reviews last updated May 22, 2026.
Get a feel of what it's like to fly with Southwest,Delta, andAllegiant Air from Knoxville to Florida Keys by reading reviews from past customers. You can also see how each airline stacks up in terms of entertainment options, comfort, food, crew/service, and boarding process.
Boarding
8.1
Crew
8.6
Entertainment
7.5
Food
7.0
Overall
7.9
Comfort
8.0
Reviews
1 / 20
2.0
MediocreDominic,Mar 2026
MCO - SMF
Boarding
8.1
Crew
8.6
Entertainment
7.5
Food
7.0
Overall
7.9
Comfort
8.0
Reviews
1 / 20
2.0
MediocreDominic,Mar 2026
MCO - SMF
Boarding
8.1
Crew
8.6
Entertainment
7.5
Food
7.0
Overall
7.9
Comfort
8.0
Reviews
1 / 20
2.0
MediocreDominic,Mar 2026
MCO - SMF
Boarding
8.1
Crew
8.6
Entertainment
7.5
Food
7.0
Overall
7.9
Comfort
8.0
Reviews
1 / 20
2.0
MediocreDominic,Mar 2026
MCO - SMF
Boarding
8.1
Crew
8.6
Entertainment
7.5
Food
7.0
Overall
7.9
Comfort
8.0
Reviews
1 / 20
2.0
MediocreDominic,Mar 2026
MCO - SMF
Related info for your journey
Find useful and relevant information for your journey from Knoxville to Florida Keys. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.
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Complete your trip
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Knoxville and Florida Keys flights
Browse other Knoxville and Florida Keys flight options. Last updated on May 22, 2026.
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Knoxville to Florida Keys flights
Consider these flights traveling from Knoxville to Florida Keys.
Top 3 airlines flying from Knoxville to Florida Keys
Discover the top 3 airlines that operate flights from Knoxville to Florida Keys. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated May 22, 2026.
| Airline | Cheapest | Average | Flexibility | On-time |
|---|---|---|---|---|
| Cheapest$82 | Average$146 | FlexibilityNo cancel fee | On-time88% | |
| Cheapest$250 | Average$391 | FlexibilityNo cancel fee | On-time71% | |
| Cheapest$268 | Average$418 | FlexibilityNo cancel fee | On-timeN/A |