$369+ Cheap flights from Mississippi to Key West (EYW)
This is the cheapest round-trip flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 1/9. Fares are subject to change and may not be available on all flights or dates of travel.
JAN — EYW
Dec 11 — Dec 181
Round-trip
1 adult, Economy
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Find cheap flights from Mississippi to Key West with Cheapflights
1. Tell us where you want to go
Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”2. Select your favorite providers
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Review each provider’s pricing and select the best option for you! Book through your favorite provider’s website for a seamless experience.Cheap flight deals from Mississippi to Key West
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Cheapest flights from Mississippi to Key WestExplore the most affordable flight options available from Mississippi to Key West. Find the lowest fares from popular airlines and budget airlines, with prices last updated on November 11, 2026.
Explore the most affordable flight options available from Mississippi to Key West. Find the lowest fares from popular airlines and budget airlines, with prices last updated on November 11, 2026.
This Delta deal was found by Cheapflights users on 11/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 11/185:30 am -
1 stop4h 18m
Wed 11/256:08 pm -
1 stop5h 57m
Deal found 11/8![Delta logo]()
$579
This American Airlines deal was found by Cheapflights users on 11/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 11/186:30 am -
2 stops9h 45m
Sat 11/215:45 pm -
1 stop5h 24m
Deal found 11/8![American Airlines logo]()
$587
This Delta deal was found by Cheapflights users on 11/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 11/185:30 am -
1 stop4h 18m
Tue 11/247:30 am -
1 stop6h 10m
Deal found 11/8![Delta logo]()
$589
This Delta deal was found by Cheapflights users on 11/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 11/165:30 am -
1 stop4h 18m
Tue 11/246:08 pm -
1 stop5h 57m
Deal found 11/10![Delta logo]()
$604
This American Airlines deal was found by Cheapflights users on 11/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 11/237:00 am -
1 stop8h 04m
Fri 11/2711:25 am -
2 stops10h 16m
Deal found 11/7![American Airlines logo]()
$627
This American Airlines deal was found by Cheapflights users on 11/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 11/166:30 am -
1 stop5h 33m
Mon 11/234:53 pm -
1 stop6h 16m
Deal found 11/10![American Airlines logo]()
$635
This American Airlines deal was found by Cheapflights users on 11/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 11/186:30 am -
2 stops9h 45m
Tue 11/2410:22 am -
2 stops11h 19m
Deal found 11/8![American Airlines logo]()
$639
This American Airlines deal was found by Cheapflights users on 11/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 11/166:30 am -
1 stop5h 33m
Tue 11/2411:25 am -
2 stops11h 44m
Deal found 11/10![American Airlines logo]()
$654
This Delta deal was found by Cheapflights users on 11/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 11/185:30 am -
1 stop4h 18m
Mon 11/237:30 am -
1 stop6h 10m
Deal found 11/8![Delta logo]()
$663
This American Airlines deal was found by Cheapflights users on 11/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 11/2210:47 am -
1 stop7h 00m
Tue 11/2410:22 am -
2 stops11h 19m
Deal found 11/8![American Airlines logo]()
$671
This American Airlines deal was found by Cheapflights users on 11/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 11/246:26 am -
2 stops12h 50m
Sat 11/287:16 pm -
1 stop5h 45m
Deal found 11/8![American Airlines logo]()
$769
This American Airlines deal was found by Cheapflights users on 11/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/306:11 am -
1 stop7h 21m
Mon 1/44:43 pm -
1 stop8h 14m
Deal found 11/10![American Airlines logo]()
$839
Best flights from Mississippi to Key WestDiscover carefully curated flight deals from Mississippi to Key West that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated November 11, 2026.
Discover carefully curated flight deals from Mississippi to Key West that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated November 11, 2026.
This Delta deal was found by Cheapflights users on 11/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 1/95:32 am -
1 stop4h 21m
Fri 1/155:00 pm -
1 stop7h 05m
Deal found 11/7![Delta logo]()
$369
This American Airlines deal was found by Cheapflights users on 11/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 1/46:11 am -
1 stop5h 32m
Tue 1/126:27 pm -
1 stop5h 19m
Deal found 11/10![American Airlines logo]()
$409
This Delta deal was found by Cheapflights users on 11/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 1/82:59 pm -
1 stop4h 50m
Fri 1/152:50 pm -
1 stop6h 34m
Deal found 11/6![Delta logo]()
$369
This Delta deal was found by Cheapflights users on 11/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 1/59:23 am -
1 stop5h 41m
Wed 1/137:30 am -
1 stop4h 58m
Deal found 11/10![Delta logo]()
$369
This American Airlines deal was found by Cheapflights users on 11/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 3/26:41 am -
1 stop6h 55m
Sat 3/67:28 pm -
1 stop5h 30m
Deal found 11/8![American Airlines logo]()
$428
This Delta deal was found by Cheapflights users on 11/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 2/193:13 pm -
1 stop4h 35m
Mon 2/227:10 am -
1 stop5h 26m
Deal found 11/11![Delta logo]()
$394
This United Airlines deal was found by Cheapflights users on 11/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 5/35:15 pm -
2 stops20h 51m
Fri 5/74:05 pm -
2 stops24h 57m
Deal found 11/10![United Airlines logo]()
$963
This Delta deal was found by Cheapflights users on 11/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 4/122:40 pm -
1 stop4h 03m
Sat 4/176:00 pm -
1 stop6h 23m
Deal found 11/7![Delta logo]()
$404
This Delta deal was found by Cheapflights users on 11/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 1/85:32 am -
1 stop4h 21m
Sat 1/167:30 am -
1 stop4h 58m
Deal found 11/6![Delta logo]()
$429
This Delta deal was found by Cheapflights users on 11/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 4/2710:40 am -
1 stop5h 31m
Sun 5/26:00 pm -
1 stop6h 23m
Deal found 11/9![Delta logo]()
$514
This American Airlines deal was found by Cheapflights users on 11/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 11/246:26 am -
2 stops12h 50m
Sat 11/287:16 pm -
1 stop5h 45m
Deal found 11/8![American Airlines logo]()
$769
This American Airlines deal was found by Cheapflights users on 11/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 4/96:00 am -
1 stop6h 21m
Mon 4/123:58 pm -
2 stops9h 00m
Deal found 11/8![American Airlines logo]()
$772
This Delta deal was found by Cheapflights users on 11/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 4/92:15 pm -
1 stop4h 28m
Mon 4/126:00 pm -
1 stop5h 07m
Deal found 11/6![Delta logo]()
$584
Last-minute flights from Mississippi to Key WestDiscover last-minute flight deals from Mississippi to Key West. Data last updated November 11, 2026 and is based on user searches.
Discover last-minute flight deals from Mississippi to Key West. Data last updated November 11, 2026 and is based on user searches.
This Delta deal was found by Cheapflights users on 11/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 11/165:30 am -
1 stop4h 18m
Tue 11/246:08 pm -
1 stop5h 57m
Deal found 11/10![Delta logo]()
$604
This American Airlines deal was found by Cheapflights users on 11/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 11/166:30 am -
1 stop5h 33m
Mon 11/234:53 pm -
1 stop6h 16m
Deal found 11/10![American Airlines logo]()
$635
This American Airlines deal was found by Cheapflights users on 11/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 11/166:30 am -
1 stop5h 33m
Tue 11/2411:25 am -
2 stops11h 44m
Deal found 11/10![American Airlines logo]()
$654
This Delta deal was found by Cheapflights users on 11/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 11/185:30 am -
1 stop4h 18m
Wed 11/256:08 pm -
1 stop5h 57m
Deal found 11/8![Delta logo]()
$579
This American Airlines deal was found by Cheapflights users on 11/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 11/186:30 am -
2 stops9h 45m
Sat 11/215:45 pm -
1 stop5h 24m
Deal found 11/8![American Airlines logo]()
$587
This Delta deal was found by Cheapflights users on 11/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 11/185:30 am -
1 stop4h 18m
Tue 11/247:30 am -
1 stop6h 10m
Deal found 11/8![Delta logo]()
$589
This American Airlines deal was found by Cheapflights users on 11/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 11/186:30 am -
2 stops9h 45m
Tue 11/2410:22 am -
2 stops11h 19m
Deal found 11/8![American Airlines logo]()
$639
This Delta deal was found by Cheapflights users on 11/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 11/185:30 am -
1 stop4h 18m
Mon 11/237:30 am -
1 stop6h 10m
Deal found 11/8![Delta logo]()
$663
This American Airlines deal was found by Cheapflights users on 11/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 11/2210:47 am -
1 stop7h 00m
Tue 11/2410:22 am -
2 stops11h 19m
Deal found 11/8![American Airlines logo]()
$671
This American Airlines deal was found by Cheapflights users on 11/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 11/237:00 am -
1 stop8h 04m
Fri 11/2711:25 am -
2 stops10h 16m
Deal found 11/7![American Airlines logo]()
$627
This American Airlines deal was found by Cheapflights users on 11/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 11/246:26 am -
2 stops12h 50m
Sat 11/287:16 pm -
1 stop5h 45m
Deal found 11/8![American Airlines logo]()
$769
This American Airlines deal was found by Cheapflights users on 11/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/306:11 am -
1 stop7h 21m
Mon 1/44:43 pm -
1 stop8h 14m
Deal found 11/10![American Airlines logo]()
$839
Find flight deals from Mississippi to Key West
Keep the following information in mind while searching for Mississippi to Key West flight deals. Data was last updated November 11, 2026.
Most accurate provider | FlightHub 3 stars |
|---|---|
Most trusted provider | FlightHub 3 stars |
Round-trip from | $369 (Delta) |
Cheapflights Fare Finder
Customize your flight search to find flights from Mississippi to Key West that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 7,457,451 searches. Data last updated November 11, 2026.
Use the filters below to find and compare flights from Mississippi to Key West that are best for you.
Fly from
Fly to
Route
Depart
Return
Cheapest round-trip
JacksonKey West
JAN Jackson-Evers Intl - EYW Key West
JANEYW
Jackson-Evers Intl
Sat 1/9
5:32 am-10:53 am
1 stop4h 21m
Key West
Fri 1/15
5:00 pm-11:05 pm
1 stop7h 05m
$369
JacksonKey West
JAN Jackson-Evers Intl - EYW Key West
JANEYW
Jackson-Evers Intl
Fri 1/8
2:59 pm-8:49 pm
1 stop4h 50m
Key West
Fri 1/15
2:50 pm-8:24 pm
1 stop6h 34m
$369
JacksonKey West
JAN Jackson-Evers Intl - EYW Key West
JANEYW
Jackson-Evers Intl
Tue 1/5
9:23 am-4:04 pm
1 stop5h 41m
Key West
Wed 1/13
7:30 am-11:28 am
1 stop4h 58m
$369
JacksonKey West
JAN Jackson-Evers Intl - EYW Key West
JANEYW
Jackson-Evers Intl
Fri 2/19
3:13 pm-8:48 pm
1 stop4h 35m
Key West
Mon 2/22
7:10 am-11:36 am
1 stop5h 26m
$394
JacksonKey West
JAN Jackson-Evers Intl - EYW Key West
JANEYW
Jackson-Evers Intl
Mon 4/12
2:40 pm-7:43 pm
1 stop4h 03m
Key West
Sat 4/17
6:00 pm-11:23 pm
1 stop6h 23m
$404
GulfportKey West
GPT Gulfport Biloxi Regional - EYW Key West
GPTEYW
Gulfport Biloxi Regional
Mon 1/4
6:11 am-12:43 pm
1 stop5h 32m
Key West
Tue 1/12
6:27 pm-10:46 pm
1 stop5h 19m
$409
GulfportKey West
GPT Gulfport Biloxi Regional - EYW Key West
GPTEYW
Gulfport Biloxi Regional
Tue 3/2
6:41 am-2:36 pm
1 stop6h 55m
Key West
Sat 3/6
7:28 pm-11:58 pm
1 stop5h 30m
$428
Quickest round-trip
JacksonKey West
JAN Jackson-Evers Intl - EYW Key West
JANEYW
Jackson-Evers Intl
Fri 1/8
5:32 am-10:53 am
1 stop4h 21m
Key West
Sat 1/16
7:30 am-11:28 am
1 stop4h 58m
$429
JacksonKey West
JAN Jackson-Evers Intl - EYW Key West
JANEYW
Jackson-Evers Intl
Tue 4/27
10:40 am-5:11 pm
1 stop5h 31m
Key West
Sun 5/2
6:00 pm-11:23 pm
1 stop6h 23m
$514
GulfportKey West
GPT Gulfport Biloxi Regional - EYW Key West
GPTEYW
Gulfport Biloxi Regional
Fri 4/9
2:15 pm-7:43 pm
1 stop4h 28m
Key West
Mon 4/12
6:00 pm-10:07 pm
1 stop5h 07m
$584
Showing 1-10 of 13 resultsSorted by cheapest first
Best time to book a flight from Mississippi to Key West
Have a flexible travel schedule? Discover the best time to fly to Key West from Mississippi with our price prediction graph.
JAN-EYW
GPT-EYW
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.
Cheapflights Insights
Everything you need to know about your flight from Mississippi to Key West
USMS-EYW
JAN-EYW
GPT-EYW
No data available for this route at this time. Please check back soon.
Related info for your journey
Find useful and relevant information for your journey from Mississippi to Key West. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.
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Alternative routes for Mississippi to Key West
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Complete your trip
Complete your trip to Key West by adding a car rental and/or hotel reservation to your travel itinerary.
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Find flights from Mississippi to Key West, based on your preferred cabin class, be it economy, premium economy, business, or first class.
Other flights to Key West
Explore flights to Key West departing from other origins. Flights are based on user searches made on Cheapflights and were last updated on November 11, 2026.
Mississippi and Key West flights
Browse other Mississippi and Key West flight options. Last updated on November 11, 2026.
Popular flight searches
Check out other popular destinations found by fellow travelers in 2026
Mississippi to Key West flights
Consider these flights traveling from Mississippi to Key West.
Top 2 airlines flying from Mississippi to Key West
Discover the top 2 airlines that operate flights from Mississippi to Key West. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 7,457,451 searches. Data last updated November 11, 2026.
| Airline | Cheapest | Average | Flexibility | On-time |
|---|---|---|---|---|
| Cheapest$248 | Average$580 | FlexibilityNo cancel fee | On-timeN/A | |
| Cheapest$298 | Average$461 | FlexibilityNo cancel fee | On-time71% |