$281+ Cheap flights from Mississippi to Key West (EYW)
This is the cheapest round-trip flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 10/2. Fares are subject to change and may not be available on all flights or dates of travel.
JAN — EYW
Oct 24 — Oct 311
Round-trip
1 adult, Economy
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Find cheap flights from Mississippi to Key West with Cheapflights
1. Tell us where you want to go
Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”2. Select your favorite providers
We find the providers serving your travel needs. Choose up to four travel providers to compare side-by-side for flights, hotels, or car rentals.3. Compare prices and book
Review each provider’s pricing and select the best option for you! Book through your favorite provider’s website for a seamless experience.Cheap flight deals from Mississippi to Key West
Cheapest
Best
Last-minute
One-way
Cheapest flights from Mississippi to Key WestExplore the most affordable flight options available from Mississippi to Key West. Find the lowest fares from popular airlines and budget airlines, with prices last updated on September 24, 2026.
Explore the most affordable flight options available from Mississippi to Key West. Find the lowest fares from popular airlines and budget airlines, with prices last updated on September 24, 2026.
This Kiwi.com deal was found by Cheapflights users on 9/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/26:46 pm -
1 stop13h 38m
Sun 10/410:59 am -
1 stop9h 06m
Deal found 9/21![Breeze Airways logo]()
$281
This Delta deal was found by Cheapflights users on 9/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 9/263:02 pm -
1 stop3h 58m
Tue 9/292:00 pm -
1 stop6h 49m
Deal found 9/22![Delta logo]()
$444
This Delta deal was found by Cheapflights users on 9/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 12/510:04 am -
1 stop6h 06m
Thu 12/107:25 am -
1 stop6h 44m
Deal found 9/20![Delta logo]()
$469
This Delta deal was found by Cheapflights users on 9/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/51:04 pm -
1 stop5h 57m
Sat 11/76:11 pm -
1 stop4h 26m
Deal found 9/21![Delta logo]()
$489
This Delta deal was found by Cheapflights users on 9/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 9/241:59 pm -
1 stop5h 01m
Mon 9/286:19 pm -
1 stop4h 49m
Deal found 9/23![Delta logo]()
$493
This American Airlines deal was found by Cheapflights users on 9/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 9/268:16 am -
2 stops10h 01m
Tue 9/296:27 pm -
1 stop5h 25m
Deal found 9/22![American Airlines logo]()
$507
This American Airlines deal was found by Cheapflights users on 9/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 12/56:45 am -
2 stops8h 41m
Thu 12/104:45 pm -
1 stop8h 12m
Deal found 9/20![American Airlines logo]()
$518
This FlightHub deal was found by Cheapflights users on 9/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure FlightHub is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/297:45 pm -
1 stop13h 34m
Sun 11/110:59 am -
1 stop9h 06m
Deal found 9/20![Breeze Airways logo]()
$540
This Delta deal was found by Cheapflights users on 9/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 10/65:35 am -
1 stop4h 12m
Sat 10/1011:51 am -
1 stop5h 26m
Deal found 9/21![Delta logo]()
$550
This Kiwi.com deal was found by Cheapflights users on 9/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 10/56:46 pm -
1 stop16h 50m
Fri 10/96:37 pm -
2 stops49h 28m
Deal found 9/20![Multiple Airlines logo]()
$561
This American Airlines deal was found by Cheapflights users on 9/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/286:11 am -
2 stops12h 22m
Mon 11/26:26 pm -
1 stop5h 15m
Deal found 9/23![American Airlines logo]()
$582
This Delta deal was found by Cheapflights users on 9/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 10/199:18 am -
1 stop6h 57m
Mon 10/266:10 pm -
1 stop5h 59m
Deal found 9/21![Delta logo]()
$644
Best flights from Mississippi to Key WestDiscover carefully curated flight deals from Mississippi to Key West that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated September 24, 2026.
Discover carefully curated flight deals from Mississippi to Key West that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated September 24, 2026.
This Delta deal was found by Cheapflights users on 9/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 12/510:04 am -
1 stop6h 06m
Thu 12/107:25 am -
1 stop6h 44m
Deal found 9/20![Delta logo]()
$469
This Kiwi.com deal was found by Cheapflights users on 9/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 10/56:46 pm -
1 stop16h 50m
Fri 10/96:37 pm -
2 stops49h 28m
Deal found 9/20![Multiple Airlines logo]()
$561
This American Airlines deal was found by Cheapflights users on 9/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/286:11 am -
1 stop5h 16m
Mon 11/26:26 pm -
1 stop5h 15m
Deal found 9/23![American Airlines logo]()
$599
This United Airlines deal was found by Cheapflights users on 9/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 12/51:55 pm -
3 stops20h 29m
Thu 12/104:10 pm -
2 stops24h 58m
Deal found 9/20![United Airlines logo]()
$958
This Delta deal was found by Cheapflights users on 9/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/51:04 pm -
1 stop5h 57m
Sat 11/76:11 pm -
1 stop4h 26m
Deal found 9/21![Delta logo]()
$489
This Delta deal was found by Cheapflights users on 9/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 10/65:35 am -
1 stop4h 12m
Sat 10/1011:51 am -
1 stop5h 26m
Deal found 9/21![Delta logo]()
$550
This American Airlines deal was found by Cheapflights users on 9/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 3/214:34 pm -
1 stop5h 03m
Sat 3/274:40 pm -
1 stop8h 12m
Deal found 9/22![American Airlines logo]()
$607
This Delta deal was found by Cheapflights users on 9/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/91:46 pm -
1 stop5h 15m
Tue 10/136:10 pm -
1 stop5h 06m
Deal found 9/24![Delta logo]()
$561
This American Airlines deal was found by Cheapflights users on 9/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/57:00 am -
2 stops11h 27m
Sat 11/74:11 pm -
1 stop7h 32m
Deal found 9/21![American Airlines logo]()
$702
This Delta deal was found by Cheapflights users on 9/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 10/51:59 pm -
1 stop5h 01m
Mon 10/127:40 am -
1 stop6h 21m
Deal found 9/24![Delta logo]()
$657
This American Airlines deal was found by Cheapflights users on 9/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 10/67:45 am -
2 stops8h 13m
Fri 10/912:48 pm -
1 stop6h 27m
Deal found 9/22![American Airlines logo]()
$762
This American Airlines deal was found by Cheapflights users on 9/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 10/56:11 am -
2 stops9h 47m
Fri 10/91:43 pm -
2 stops11h 16m
Deal found 9/20![American Airlines logo]()
$767
This Delta deal was found by Cheapflights users on 9/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 11/111:20 pm -
1 stop5h 40m
Sun 11/156:08 pm -
1 stop5h 57m
Deal found 9/20![Delta logo]()
$704
This American Airlines deal was found by Cheapflights users on 9/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 10/512:49 pm -
1 stop5h 00m
Mon 10/125:28 pm -
2 stops7h 31m
Deal found 9/24![American Airlines logo]()
$830
This Delta deal was found by Cheapflights users on 9/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 10/43:02 pm -
1 stop3h 58m
Thu 10/811:51 am -
1 stop5h 26m
Deal found 9/19![Delta logo]()
$757
This Delta deal was found by Cheapflights users on 9/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/1211:14 am -
1 stop4h 56m
Sun 11/156:08 pm -
1 stop5h 57m
Deal found 9/23![Delta logo]()
$775
This American Airlines deal was found by Cheapflights users on 9/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/712:49 pm -
1 stop5h 00m
Tue 10/134:41 pm -
1 stop8h 08m
Deal found 9/23![American Airlines logo]()
$1,075
Last-minute flights from Mississippi to Key WestDiscover last-minute flight deals from Mississippi to Key West. Data last updated September 24, 2026 and is based on user searches.
Discover last-minute flight deals from Mississippi to Key West. Data last updated September 24, 2026 and is based on user searches.
This Delta deal was found by Cheapflights users on 9/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 9/241:59 pm -
1 stop5h 01m
Mon 9/286:19 pm -
1 stop4h 49m
Deal found 9/23![Delta logo]()
$493
This Delta deal was found by Cheapflights users on 9/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 9/263:02 pm -
1 stop3h 58m
Tue 9/292:00 pm -
1 stop6h 49m
Deal found 9/22![Delta logo]()
$444
This American Airlines deal was found by Cheapflights users on 9/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 9/268:16 am -
2 stops10h 01m
Tue 9/296:27 pm -
1 stop5h 25m
Deal found 9/22![American Airlines logo]()
$507
This Kiwi.com deal was found by Cheapflights users on 9/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/26:46 pm -
1 stop13h 38m
Sun 10/410:59 am -
1 stop9h 06m
Deal found 9/21![Breeze Airways logo]()
$281
This Kiwi.com deal was found by Cheapflights users on 9/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/26:46 pm -
1 stop13h 38m
Sun 10/410:59 am -
2 stops32h 07m
Deal found 9/21![Multiple Airlines logo]()
$700
This Kiwi.com deal was found by Cheapflights users on 9/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 10/56:46 pm -
1 stop16h 50m
Fri 10/96:37 pm -
2 stops49h 28m
Deal found 9/20![Multiple Airlines logo]()
$561
This Delta deal was found by Cheapflights users on 9/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 10/65:35 am -
1 stop4h 12m
Sat 10/1011:51 am -
1 stop5h 26m
Deal found 9/21![Delta logo]()
$550
This Delta deal was found by Cheapflights users on 9/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 10/199:18 am -
1 stop6h 57m
Mon 10/266:10 pm -
1 stop5h 59m
Deal found 9/21![Delta logo]()
$644
This American Airlines deal was found by Cheapflights users on 9/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 10/197:19 am -
2 stops11h 14m
Mon 10/267:19 pm -
1 stop5h 36m
Deal found 9/21![American Airlines logo]()
$720
This American Airlines deal was found by Cheapflights users on 9/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/286:11 am -
2 stops12h 22m
Mon 11/26:26 pm -
1 stop5h 15m
Deal found 9/23![American Airlines logo]()
$582
This FlightHub deal was found by Cheapflights users on 9/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure FlightHub is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/297:45 pm -
1 stop13h 34m
Sun 11/110:59 am -
1 stop9h 06m
Deal found 9/20![Breeze Airways logo]()
$540
This American Airlines deal was found by Cheapflights users on 9/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/296:11 am -
2 stops12h 22m
Sun 11/17:18 pm -
1 stop5h 39m
Deal found 9/20![American Airlines logo]()
$730
One-way flights from Mississippi to Key WestSearch for one-way flight options from Mississippi to Key West. Find affordable one-way fares based on user searches. Data last updated September 24, 2026.
Search for one-way flight options from Mississippi to Key West. Find affordable one-way fares based on user searches. Data last updated September 24, 2026.
This American Airlines deal was found by Cheapflights users on 9/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 9/2710:48 am -
1 stop7h 04m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/22![American Airlines logo]()
$471
Find flight deals from Mississippi to Key West
Keep the following information in mind while searching for Mississippi to Key West flight deals. Data was last updated September 24, 2026.
Most accurate provider | FlightHub 3 stars |
|---|---|
Most trusted provider | FlightHub 3 stars |
Round-trip from | $469 (Delta) |
Cheapflights Fare Finder
Customize your flight search to find flights from Mississippi to Key West that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 7,457,451 searches. Data last updated September 24, 2026.
Use the filters below to find and compare flights from Mississippi to Key West that are best for you.
Fly from
Fly to
Route
Depart
Return
Cheapest round-trip
GulfportKey West
GPT Gulfport Biloxi Regional - EYW Key West
GPTEYW
Gulfport Biloxi Regional
Sat 12/5
10:04 am-5:10 pm
1 stop6h 06m
Key West
Thu 12/10
7:25 am-1:09 pm
1 stop6h 44m
$469
Quickest round-trip
JacksonKey West
JAN Jackson-Evers Intl - EYW Key West
JANEYW
Jackson-Evers Intl
Sun 9/27
10:48 am-6:52 pm
1 stop7h 04m
Key West
Wed 12/31
12:00 am-11:00 pm
Nonstop0h 00m
$471
JacksonKey West
JAN Jackson-Evers Intl - EYW Key West
JANEYW
Jackson-Evers Intl
Thu 11/5
1:04 pm-8:01 pm
1 stop5h 57m
Key West
Sat 11/7
6:11 pm-9:37 pm
1 stop4h 26m
$489
JacksonKey West
JAN Jackson-Evers Intl - EYW Key West
JANEYW
Jackson-Evers Intl
Tue 10/6
5:35 am-10:47 am
1 stop4h 12m
Key West
Sat 10/10
11:51 am-4:17 pm
1 stop5h 26m
$550
GulfportKey West
GPT Gulfport Biloxi Regional - EYW Key West
GPTEYW
Gulfport Biloxi Regional
Mon 10/5
6:46 pm-12:36 pm
1 stop16h 50m
Key West
Fri 10/9
6:37 pm-7:05 pm
2 stops49h 28m
$561
GulfportKey West
GPT Gulfport Biloxi Regional - EYW Key West
GPTEYW
Gulfport Biloxi Regional
Fri 10/9
1:46 pm-8:01 pm
1 stop5h 15m
Key West
Tue 10/13
6:10 pm-10:16 pm
1 stop5h 06m
$561
GulfportKey West
GPT Gulfport Biloxi Regional - EYW Key West
GPTEYW
Gulfport Biloxi Regional
Wed 10/28
6:11 am-12:27 pm
1 stop5h 16m
Key West
Mon 11/2
6:26 pm-10:41 pm
1 stop5h 15m
$599
GulfportKey West
GPT Gulfport Biloxi Regional - EYW Key West
GPTEYW
Gulfport Biloxi Regional
Sun 3/21
4:34 pm-10:37 pm
1 stop5h 03m
Key West
Sat 3/27
4:40 pm-11:52 pm
1 stop8h 12m
$607
GulfportKey West
GPT Gulfport Biloxi Regional - EYW Key West
GPTEYW
Gulfport Biloxi Regional
Mon 10/5
1:59 pm-8:00 pm
1 stop5h 01m
Key West
Mon 10/12
7:40 am-1:01 pm
1 stop6h 21m
$657
JacksonKey West
JAN Jackson-Evers Intl - EYW Key West
JANEYW
Jackson-Evers Intl
Thu 11/5
7:00 am-7:27 pm
2 stops11h 27m
Key West
Sat 11/7
4:11 pm-10:43 pm
1 stop7h 32m
$702
Showing 1-10 of 18 resultsSorted by cheapest first
Best time to book a flight from Mississippi to Key West
Have a flexible travel schedule? Discover the best time to fly to Key West from Mississippi with our price prediction graph.
GPT-EYW
JAN-EYW
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.
Cheapflights Insights
Everything you need to know about your flight from Mississippi to Key West
USMS-EYW
GPT-EYW
JAN-EYW
No data available for this route at this time. Please check back soon.
Related info for your journey
Find useful and relevant information for your journey from Mississippi to Key West. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.
Browse thousands of different options on Cheapflights for your next trip
Toggle through the tabs below to find thousands of options on Cheapflights for your next trip.
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Alternative routes for Mississippi to Key West
See prices for flight routes from nearby airports that may be better suited for you.
Complete your trip
Complete your trip to Key West by adding a car rental and/or hotel reservation to your travel itinerary.
Search flights from Mississippi to Key West by cabin class
Find flights from Mississippi to Key West, based on your preferred cabin class, be it economy, premium economy, business, or first class.
Other flights to Key West
Explore flights to Key West departing from other origins. Flights are based on user searches made on Cheapflights and were last updated on September 24, 2026.
Mississippi and Key West flights
Browse other Mississippi and Key West flight options. Last updated on September 24, 2026.
Popular flight searches
Check out other popular destinations found by fellow travelers in 2026
Mississippi to Key West flights
Consider these flights traveling from Mississippi to Key West.
Top 2 airlines flying from Mississippi to Key West
Discover the top 2 airlines that operate flights from Mississippi to Key West. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 7,457,451 searches. Data last updated September 24, 2026.
| Airline | Cheapest | Average | Flexibility | On-time |
|---|---|---|---|---|
| Cheapest$298 | Average$461 | FlexibilityNo cancel fee | On-time71% | |
| Cheapest$308 | Average$546 | FlexibilityNo cancel fee | On-timeN/A |