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Key West

$156+ Cheap flights from Iowa to Key West (EYW)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 2/21. Fares are subject to change and may not be available on all flights or dates of travel.
DSM — EYW
Mar 5 — Mar 121
Thu 3/5
Thu 3/12
1 adult, Economy
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Cheap flight deals from Iowa to Key West

Cheapest flights from Iowa to Key West
Explore the most affordable flight options available from Iowa to Key West. Find the lowest fares from popular airlines and budget airlines, with prices last updated on February 3, 2026.

This Delta deal was found by Cheapflights users on 2/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 10/2711:00 am
MLI
-
EYW
1 stop5h 11m
Delta
Wed 11/46:00 pm
EYW
-
MLI
1 stop5h 30m
Delta
Deal found 2/1$283
This American Airlines deal was found by Cheapflights users on 2/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 4/182:42 pm
OMA
-
EYW
1 stop6h 54m
American Airlines
Tue 4/216:49 pm
EYW
-
OMA
1 stop6h 10m
American Airlines
Deal found 2/2$284
This American Airlines deal was found by Cheapflights users on 2/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 2/2512:02 pm
OMA
-
EYW
1 stop6h 13m
American Airlines
Wed 3/48:04 am
EYW
-
OMA
1 stop7h 06m
American Airlines
Deal found 2/1$286
This Delta deal was found by Cheapflights users on 2/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 10/2511:00 am
MLI
-
EYW
1 stop7h 43m
Delta
Sat 10/316:00 pm
EYW
-
MLI
1 stop5h 30m
Delta
Deal found 2/1$286
This American Airlines deal was found by Cheapflights users on 2/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 3/251:52 pm
DSM
-
EYW
1 stop7h 45m
American Airlines
Wed 4/14:40 pm
EYW
-
DSM
1 stop6h 19m
American Airlines
Deal found 2/2$289
This American Airlines deal was found by Cheapflights users on 2/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 2/273:00 pm
OMA
-
EYW
1 stop6h 37m
American Airlines
Fri 3/64:40 pm
EYW
-
OMA
1 stop8h 35m
American Airlines
Deal found 2/3$289
This Delta deal was found by Cheapflights users on 2/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 10/2511:00 am
MLI
-
EYW
1 stop7h 43m
Delta
Thu 11/56:00 pm
EYW
-
MLI
1 stop5h 30m
Delta
Deal found 2/1$289
This American Airlines deal was found by Cheapflights users on 1/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 2/247:01 am
OMA
-
EYW
1 stop6h 39m
American Airlines
Tue 3/31:55 pm
EYW
-
OMA
2 stops9h 35m
American Airlines
Deal found 1/31$291
This American Airlines deal was found by Cheapflights users on 2/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 3/27:00 am
DSM
-
EYW
2 stops11h 15m
American Airlines
Tue 3/106:49 pm
EYW
-
DSM
1 stop5h 51m
American Airlines
Deal found 2/1$294
This American Airlines deal was found by Cheapflights users on 2/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 3/410:04 am
DSM
-
EYW
2 stops11h 18m
American Airlines
Wed 3/113:56 pm
EYW
-
DSM
2 stops8h 44m
American Airlines
Deal found 2/1$300
This American Airlines deal was found by Cheapflights users on 2/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 3/201:52 pm
DSM
-
EYW
1 stop7h 45m
American Airlines
Tue 3/246:49 pm
EYW
-
DSM
1 stop5h 51m
American Airlines
Deal found 2/3$309
This Delta deal was found by Cheapflights users on 2/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 7/412:00 pm
OMA
-
EYW
1 stop6h 44m
Delta
Tue 7/76:00 pm
EYW
-
OMA
1 stop6h 55m
Delta
Deal found 2/2$311

Find flight deals from Iowa to Key West

Keep the following information in mind while searching for Iowa to Key West flight deals. Data was last updated February 3, 2026.

Most accurate provider

FlightHub
3 stars

Most trusted provider

FlightHub
3 stars

Round-trip from

$284
(American Airlines)

One-way from

$156
(Kiwi.com)

Popular in

June

Cheapest in

September

Average price

$578
Provider with most accurate pricing for Des Moines-Key West flight deals.
Search Deals
Provider most trusted by Cheapflights users for Des Moines-Key West flights.
Search Deals
From Iowa to Key West
Search Deals
One-way flight from Iowa to Key West
Search Deals
Highest demand for flights based on searches. 8% potential increase in price ($41 potential increase over avg. RT price).
Search Deals
Cheapest flight prices on average. 2% potential price decrease ($12 potential savings vs. average RT price).
Search Deals
Average for round-trip flights in February 2026
Search Deals

Cheapflights Fare Finder

 
Customize your flight search to find flights from Iowa to Key West that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated February 3, 2026.
Use the filters below to find and compare flights from Iowa to Key West that are best for you.

Fly from

Iowa

Fly to

Key West

Route

Depart

Return

Price

OmahaKey West

OMA - EYW

OMAEYW

Omaha Eppley Airfield

Fri 2/27

3:00 pm-10:37 pm

1 stop6h 37m

Key West

Fri 3/6

4:40 pm-12:15 am

1 stop8h 35m

$289

Des MoinesKey West

DSM - EYW

DSMEYW

Des Moines

Wed 3/4

2:00 pm-10:22 pm

1 stop7h 22m

Key West

Wed 3/11

7:45 am-1:07 pm

1 stop6h 22m

$289

Des MoinesKey West

DSM - EYW

DSMEYW

Des Moines

Sat 4/18

11:09 am-10:58 pm

2 stops10h 49m

Key West

Thu 4/23

6:46 pm-11:49 pm

1 stop6h 03m

$294

Des MoinesKey West

DSM - EYW

DSMEYW

Des Moines

Fri 4/24

11:09 am-10:58 pm

2 stops10h 49m

Key West

Tue 4/28

6:49 pm-11:49 pm

1 stop6h 00m

$294

Des MoinesKey West

DSM - EYW

DSMEYW

Des Moines

Mon 3/23

10:04 am-6:19 pm

1 stop7h 15m

Key West

Tue 3/31

6:49 pm-11:48 pm

1 stop5h 59m

$309

Cedar RapidsKey West

CID - EYW

CIDEYW

Cedar Rapids

Tue 4/7

9:15 am-6:19 pm

1 stop8h 04m

Key West

Tue 4/14

5:03 pm-10:18 pm

1 stop6h 15m

$314

Cedar RapidsKey West

CID - EYW

CIDEYW

Cedar Rapids

Tue 3/24

6:36 am-3:57 pm

1 stop8h 21m

Key West

Mon 3/30

6:49 pm-11:33 pm

1 stop5h 44m

$314

Des MoinesKey West

DSM - EYW

DSMEYW

Des Moines

Sat 2/21

2:02 pm-10:37 pm

1 stop7h 35m

Key West

Wed 2/25

6:53 pm-11:40 pm

1 stop5h 47m

$314

OmahaKey West

OMA - EYW

OMAEYW

Omaha Eppley Airfield

Tue 3/3

6:20 am-1:15 pm

1 stop5h 55m

Key West

Tue 3/10

3:20 pm-10:30 pm

1 stop8h 10m

$339

OmahaKey West

OMA - EYW

OMAEYW

Omaha Eppley Airfield

Sat 4/18

12:13 pm-10:58 pm

2 stops9h 45m

Key West

Tue 4/21

6:49 pm-11:59 pm

1 stop6h 10m

$342

Flights are sorted by cheapest round-trip flights first.

Deals found on 2/2

Showing 1-10 of 41 results
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Best time to book a flight from Iowa to Key West

Have a flexible travel schedule? Discover the best time to fly to Key West from Iowa with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Iowa to Key West

What is the cheapest month to book a flight from Iowa to Key West?

Currently, July is the cheapest month in which you can book a flight from Iowa to Key West (average of $82). Flying from Iowa to Key West in December is currently the most expensive (average of $322). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

Related info for your journey

Find useful and relevant information for your journey from Iowa to Key West. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airport do you fly into for flights to Key West from Iowa?

    Located just 2.6 mi from the city center, Key West (EYW) is the airport most travelers will use when flying to Key West from Iowa.

  • How long is the flight from Iowa to Key West?

    Airlines like American Airlines, United Airlines, and Allegiant Air fly from Iowa to Key West in about 6h 37m. The time it takes to get you to your destination can typically vary by up to 11h 55m. The distance between Iowa and Key West is about 1413 mi. This flight may include one or multiple stops.

  • What are the most popular routes from Iowa to Key West?

    While some choose either Cedar Rapids - Key West or Omaha Eppley Airfield - Key West, Des Moines - Key West is the most popular route from Iowa to Key West.

  • Can I find deals for flights from Iowa to Key West that include hotel bookings?

    Yes. In addition to deals on Iowa to Key West flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Iowa to Key West?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Iowa to Key West.

  • Can I find deals for business class flights from Iowa to Key West?

    Yes. Cheapflights offers flight deals from Iowa to Key West by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Iowa to Key West?

    Currently, July is the cheapest month in which you can book a flight from Iowa to Key West (average of $82). Flying from Iowa to Key West in December is currently the most expensive (average of $322). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Browse thousands of different options on Cheapflights for your next trip

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Alternative routes for Iowa to Key West

See prices for flight routes from nearby airports that may be better suited for you.
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Top 4 airlines flying from Iowa to Key West

Discover the top 4 airlines that operate flights from Iowa to Key West. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated February 3, 2026.
AirlineCheapestAverageFlexibilityOn-time
Allegiant AirCheapest$76Average$174FlexibilityNo cancel feeOn-time88%
American AirlinesCheapest$259Average$476FlexibilityNo cancel feeOn-time71%
DeltaCheapest$268Average$423FlexibilityNo cancel feeOn-timeN/A
United AirlinesCheapest$281Average$459FlexibilityNo cancel feeOn-time69%

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