HomeSearch by dateVacation packagesHotelsFlight dealsCar rentalTravel tips & news
Key West

$142+ Cheap flights from Iowa to Key West (EYW)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 6/10. Fares are subject to change and may not be available on all flights or dates of travel.
DSM — EYW
May 5 — May 121
Mon 5/5
Mon 5/12
1 adult, Economy
We work with more than 300 partners to bring you better travel deals

Find cheap flights from Iowa to Key West with Cheapflights

1. Tell us where you want to go

Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”

2. Select your favorite providers

We find the providers serving your travel needs. Choose up to four travel providers to compare side-by-side for flights, hotels, or car rentals.

3. Compare prices and book

Review each provider’s pricing and select the best option for you! Book through your favorite provider’s website for a seamless experience.

Cheap flight deals from Iowa to Key West

Keep the following information in mind while searching for Iowa to Key West flight deals. Data was last updated April 30, 2025.

Most accurate provider

FlightHub
3 stars

Most trusted provider

eDreams
3 stars

Round-trip from

$239
(American Airlines)

One-way from

$142
(Delta)

Popular in

June

Cheapest in

April

Average price

$319
Provider with most accurate pricing for Des Moines-Key West flight deals.
Search Deals
Provider most trusted by Cheapflights users for Des Moines-Key West flights.
Search Deals
From Iowa to Key West
Search Deals
One-way flight from Iowa to Key West
Search Deals
Highest demand for flights based on searches. 12% potential increase in price ($60 potential increase over avg. RT price).
Search Deals
Cheapest flight prices on average. 3% potential price decrease ($14 potential savings vs. average RT price).
Search Deals
Average for round-trip flights in April 2025
Search Deals

Find flight deals from Iowa to Key West

Cheapest flights from Iowa to Key West
Explore the most affordable flight options available from Iowa to Key West. Find the lowest fares from popular airlines and budget airlines, with prices last updated on April 30, 2025.

This American Airlines deal was found by Cheapflights users on 4/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 5/285:00 amMLI - EYW
1 stop6h 10mAmerican Airlines
Wed 6/42:20 pmEYW - MLI
1 stop8h 04mAmerican Airlines
Deal found 4/28$239
This Delta deal was found by Cheapflights users on 4/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 7/226:00 amCID - EYW
1 stop6h 08mDelta
Tue 7/296:27 pmEYW - CID
1 stop5h 17mDelta
Deal found 4/29$251
This American Airlines deal was found by Cheapflights users on 4/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 9/305:14 amCID - EYW
2 stops10h 34mAmerican Airlines
Tue 10/75:16 pmEYW - CID
1 stop5h 16mAmerican Airlines
Deal found 4/29$256
This Mytrip deal was found by Cheapflights users on 4/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 5/245:15 pmCID - EYW
1 stop15h 25mAllegiant Air
Sat 5/313:52 pmEYW - CID
1 stop27h 21mAllegiant Air
Deal found 4/29$264
This Delta deal was found by Cheapflights users on 4/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 11/811:05 amOMA - EYW
1 stop7h 39mDelta
Wed 11/126:00 pmEYW - OMA
1 stop6h 56mDelta
Deal found 4/29$269
This Delta deal was found by Cheapflights users on 4/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 6/1011:24 amDSM - EYW
1 stop7h 15mDelta
Tue 6/246:29 pmEYW - DSM
1 stop5h 34mDelta
Deal found 4/29$269
This American Airlines deal was found by Cheapflights users on 4/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 5/295:32 amDSM - EYW
2 stops10h 20mAmerican Airlines
Thu 6/51:24 pmEYW - DSM
2 stops11h 42mAmerican Airlines
Deal found 4/29$274
This American Airlines deal was found by Cheapflights users on 4/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 11/85:41 amOMA - EYW
2 stops11h 46mAmerican Airlines
Wed 11/124:00 pmEYW - OMA
2 stops7h 07mAmerican Airlines
Deal found 4/29$286
This United Airlines deal was found by Cheapflights users on 4/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 5/2411:25 amCID - EYW
2 stops29h 40mUnited Airlines
Sat 5/318:45 amEYW - CID
2 stops13h 41mUnited Airlines
Deal found 4/29$414
This Mytrip deal was found by Cheapflights users on 4/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 6/137:55 pmOMA - EYW
1 stop18h 08mMultiple Airlines
Thu 6/1910:32 amEYW - OMA
3 stops25h 14mMultiple Airlines
Deal found 4/29$429
This United Airlines deal was found by Cheapflights users on 4/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 9/58:20 amMLI - EYW
2 stops22h 40mUnited Airlines
Mon 9/81:00 pmEYW - MLI
3 stops31h 27mUnited Airlines
Deal found 4/28$437
This United Airlines deal was found by Cheapflights users on 4/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 9/62:58 pmDSM - EYW
2 stops20h 17mUnited Airlines
Mon 9/86:45 pmEYW - DSM
2 stops20h 25mUnited Airlines
Deal found 4/29$448

Cheapflights Fare Finder

Customize your flight search to find flights from Iowa to Key West that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated April 30, 2025.
Use the filters below to find and compare flights from Iowa to Key West that are best for you.

Fly from

Iowa

Fly to

Key West

Route

Depart

Return

Price

MolineKey West

MLI - EYW

MLIEYW

Moline Quad-City

Wed 5/28

5:00 am-12:10 pm

1 stop6h 10m

Key West

Wed 6/4

2:20 pm-9:24 pm

1 stop8h 04m

$239

Cedar RapidsKey West

CID - EYW

CIDEYW

Cedar Rapids

Tue 7/22

6:00 am-1:08 pm

1 stop6h 08m

Key West

Tue 7/29

6:27 pm-10:44 pm

1 stop5h 17m

$251

Cedar RapidsKey West

CID - EYW

CIDEYW

Cedar Rapids

Sat 5/24

5:15 pm-9:40 am

1 stop15h 25m

Key West

Sat 5/31

3:52 pm-6:13 pm

1 stop27h 21m

$264

Des MoinesKey West

DSM - EYW

DSMEYW

Des Moines

Tue 6/10

11:24 am-7:39 pm

1 stop7h 15m

Key West

Tue 6/24

6:29 pm-11:03 pm

1 stop5h 34m

$269

Des MoinesKey West

DSM - EYW

DSMEYW

Des Moines

Thu 5/29

5:32 am-4:52 pm

2 stops10h 20m

Key West

Thu 6/5

1:24 pm-12:06 am

2 stops11h 42m

$274

OmahaKey West

OMA - EYW

OMAEYW

Omaha Eppley Airfield

Mon 7/14

6:00 am-4:18 pm

2 stops9h 18m

Key West

Sat 7/19

1:22 pm-11:59 pm

2 stops11h 37m

$352

Cedar RapidsKey West

CID - EYW

CIDEYW

Cedar Rapids

Tue 7/22

6:15 am-4:08 pm

1 stop8h 53m

Key West

Sat 7/26

1:22 pm-11:15 pm

2 stops10h 53m

$354

Cedar RapidsKey West

CID - EYW

CIDEYW

Cedar Rapids

Sat 5/24

11:25 am-6:05 pm

2 stops29h 40m

Key West

Sat 5/31

8:45 am-9:26 pm

2 stops13h 41m

$414

OmahaKey West

OMA - EYW

OMAEYW

Omaha Eppley Airfield

Fri 6/13

7:55 pm-3:03 pm

1 stop18h 08m

Key West

Thu 6/19

10:32 am-10:46 am

3 stops25h 14m

$429

MolineKey West

MLI - EYW

MLIEYW

Moline Quad-City

Fri 9/5

8:20 am-8:00 am

2 stops22h 40m

Key West

Mon 9/8

1:00 pm-7:27 pm

3 stops31h 27m

$437

Flights are sorted by cheapest round-trip flights first.

Deals found on 4/29

Showing 1-10 of 21 results
1
2
3

Best time to book a flight from Iowa to Key West

Have a flexible travel schedule? Discover the best time to fly to Key West from Iowa with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Iowa to Key West

What is the cheapest month to book a flight from Iowa to Key West?

Currently, August is the cheapest month in which you can book a flight from Iowa to Key West (average of $328). Flying from Iowa to Key West in March is currently the most expensive (average of $493). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from IA to EYW?

Find hourly flight availability from Iowa to Key West. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated April 30, 2025.

When flying from Iowa to Key West, the time of day you decide to fly out makes little to no difference towards the overall price you’ll pay on tickets.

Rainfall in Key West by month

Plan your trip to Key West by taking into account the average rainfall totals by month.

In terms of precipitation, rainfall in Key West ranges from 1.5 - 6.7 inches per month. September is typically the wettest month, when rainfall can reach 6.7 in. February is typically the driest time to visit Key West when rainfall is around 1.5 in.

Temperature in Key West by month

Plan your trip to Key West by taking into account the average temperature totals by month.

If weather is an important factor for your trip to Key West, use this chart to help with planning. For those seeking warmer temperatures, June is the ideal time of year to visit, when temperatures reach an average of 84.2 F. Travelers looking to avoid the cold should look outside of January, when temperatures are typically at their lowest (around 69.8 F).

Reviews of airlines servicing Key West

Get insights into the airlines that provide service to Key West. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Key West. Reviews last updated April 30, 2025.
Get a feel of what it's like to fly with Delta, United Airlines and Allegiant Air from Iowa to Key West by reading reviews from past customers. Users can see the overall rating for each airline as well as how each is rated in terms of entertainment options, comfort, food, crew/service, and boarding process.
Delta
8.0
Very good
7,936 reviews

Entertainment

7.9

Boarding

8.2

Overall

8.0

Crew

8.5

Food

7.3

Comfort

7.9

Reviews

1 / 20
2.0
Mediocre

Joseph,Aug 2023

MSP - MCO

Even if you have delta comfort plus, they will move your overhead bag. One of the perks for upgrading is that you have dedicated space for your carry on with comfort plus with delta. They moved my carry on luggage (3) compartments back and put in bags for other passengers that should have gone under their respective seats. When deboarding the plane, there was no help from anyone to retrieve my luggage back several rows. Delta is turning into pure garbage.
Delta
8.0
Very good
7,936 reviews
Delta
8.0
Very good
7,936 reviews

Entertainment

7.9

Boarding

8.2

Overall

8.0

Crew

8.5

Food

7.3

Comfort

7.9

Reviews

1 / 20
2.0
Mediocre

Joseph,Aug 2023

MSP - MCO

Even if you have delta comfort plus, they will move your overhead bag. One of the perks for upgrading is that you have dedicated space for your carry on with comfort plus with delta. They moved my carry on luggage (3) compartments back and put in bags for other passengers that should have gone under their respective seats. When deboarding the plane, there was no help from anyone to retrieve my luggage back several rows. Delta is turning into pure garbage.
United Airlines
7.4
Good
8,696 reviews
Delta
8.0
Very good
7,936 reviews

Entertainment

7.9

Boarding

8.2

Overall

8.0

Crew

8.5

Food

7.3

Comfort

7.9

Reviews

1 / 20
2.0
Mediocre

Joseph,Aug 2023

MSP - MCO

Even if you have delta comfort plus, they will move your overhead bag. One of the perks for upgrading is that you have dedicated space for your carry on with comfort plus with delta. They moved my carry on luggage (3) compartments back and put in bags for other passengers that should have gone under their respective seats. When deboarding the plane, there was no help from anyone to retrieve my luggage back several rows. Delta is turning into pure garbage.
Allegiant Air
7.3
Good
734 reviews
Delta
8.0
Very good
7,936 reviews

Entertainment

7.9

Boarding

8.2

Overall

8.0

Crew

8.5

Food

7.3

Comfort

7.9

Reviews

1 / 20
2.0
Mediocre

Joseph,Aug 2023

MSP - MCO

Even if you have delta comfort plus, they will move your overhead bag. One of the perks for upgrading is that you have dedicated space for your carry on with comfort plus with delta. They moved my carry on luggage (3) compartments back and put in bags for other passengers that should have gone under their respective seats. When deboarding the plane, there was no help from anyone to retrieve my luggage back several rows. Delta is turning into pure garbage.
American Airlines
7.2
Good
10,000 reviews
Delta
8.0
Very good
7,936 reviews

Entertainment

7.9

Boarding

8.2

Overall

8.0

Crew

8.5

Food

7.3

Comfort

7.9

Reviews

1 / 20
2.0
Mediocre

Joseph,Aug 2023

MSP - MCO

Even if you have delta comfort plus, they will move your overhead bag. One of the perks for upgrading is that you have dedicated space for your carry on with comfort plus with delta. They moved my carry on luggage (3) compartments back and put in bags for other passengers that should have gone under their respective seats. When deboarding the plane, there was no help from anyone to retrieve my luggage back several rows. Delta is turning into pure garbage.

Related info for your journey

Find useful and relevant information for your journey from Iowa to Key West. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airport do you fly into for flights to Key West from Iowa?

    Located just 2.6 mi from the city center, Key West (EYW) is the airport most travelers will use when flying to Key West from Iowa.

  • What are the cheapest airlines to fly from Iowa to Key West one-way?

    $142 is the cheapest one-way deal found within the past few days, from Delta. You may also be able to find cheap deals on American Airlines and United Airlines, with prices starting from $147 and $444, respectively.

  • What are the most popular routes from Iowa to Key West?

    While some choose either Omaha Eppley Airfield - Key West or Cedar Rapids - Key West, Moline Quad-City - Key West is the most popular route from Iowa to Key West.

  • Can I find deals for flights from Iowa to Key West that include hotel bookings?

    Yes. In addition to deals on Iowa to Key West flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Iowa to Key West?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Iowa to Key West.

  • Can I find deals for business class flights from Iowa to Key West?

    Yes. Cheapflights offers flight deals from Iowa to Key West by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Iowa to Key West?

    Currently, August is the cheapest month in which you can book a flight from Iowa to Key West (average of $328). Flying from Iowa to Key West in March is currently the most expensive (average of $493). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Browse thousands of different options on Cheapflights for your next trip

Toggle through the tabs below to find thousands of options on Cheapflights for your next trip.

Alternative routes for Iowa to Key West

See prices for flight routes from nearby airports that may be better suited for you.
LaGuardia to Fort Lauderdale flights
John F Kennedy Intl to Miami flights
Newark to Fort Lauderdale flights
LaGuardia to Miami flights
Newark to Miami flights
Newark to Orlando flights
John F Kennedy Intl to Orlando flights
LaGuardia to Orlando flights
John F Kennedy Intl to Fort Lauderdale flights
Los Angeles to Miami flights
Newark to Tampa flights
Los Angeles to Orlando flights
John F Kennedy Intl to West Palm Beach flights
John F Kennedy Intl to Tampa flights
Dallas/Fort Worth to Miami flights
O'Hare Intl to Orlando flights
Boston to Miami flights
Boston to Orlando flights
Dallas/Fort Worth to Fort Lauderdale flights
Philadelphia to Orlando flights
O'Hare Intl to Miami flights
Dallas/Fort Worth to Orlando flights
Baltimore to Fort Lauderdale flights
Atlanta to Miami flights
Reagan-National to Miami flights
O'Hare Intl to Fort Lauderdale flights
Baltimore to Miami flights
Philadelphia to Miami flights
Dulles Intl to Miami flights
LaGuardia to Tampa flights
Philadelphia to Fort Lauderdale flights
Atlanta to Fort Lauderdale flights
Los Angeles to Fort Lauderdale flights
Newark to West Palm Beach flights
Hobby to Orlando flights
Dulles Intl to Orlando flights
Baltimore to Orlando flights
Boston to Fort Lauderdale flights
Reagan-National to Orlando flights
LaGuardia to West Palm Beach flights
O'Hare Intl to Tampa flights
Seattle to Orlando flights
Denver to Orlando flights
Boston to Tampa flights
San Francisco to Miami flights
Providence to Orlando flights
Dulles Intl to Fort Lauderdale flights
Dulles Intl to Tampa flights
Cleveland to Orlando flights
Denver to Miami flights

Top 3 airlines flying from Iowa to Key West

Discover the top 3 airlines that operate flights from Iowa to Key West. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated April 30, 2025.
AirlineCheapestAverageFlexibilityOn-time
American AirlinesCheapest$241Average$408FlexibilityNo cancel feeOn-time71%
DeltaCheapest$268Average$453FlexibilityNo cancel feeOn-timeN/A
United AirlinesCheapest$281Average$543FlexibilityNo cancel feeOn-time69%

100% Free

Cheapflights is completely free to use, so you can start saving the moment you arrive.

Book with Flexibility

Our users can plan ahead with confidence and find flights with no change fees

Travel Smart

Millions of people come to us for their flight needs every year. We help make travel planning easy by providing useful insights and data-driven graphs that can inform your decisions.