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Key West

$158+ Cheap flights from Iowa to Key West (EYW)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 1/17. Fares are subject to change and may not be available on all flights or dates of travel.
DSM — EYW
Jan 17 — Jan 241
Sat 1/17
Sat 1/24
1 adult, Economy
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Cheap flight deals from Iowa to Key West

Cheapest flights from Iowa to Key West
Explore the most affordable flight options available from Iowa to Key West. Find the lowest fares from popular airlines and budget airlines, with prices last updated on December 18, 2025.

This Kiwi.com deal was found by Cheapflights users on 12/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 12/232:36 pmMLI - EYW
1 stop15h 31mMultiple Airlines
Mon 12/2910:01 pmEYW - MLI
1 stop16h 45mMultiple Airlines
Deal found 12/17$300
This Kiwi.com deal was found by Cheapflights users on 12/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 12/2110:14 amMLI - EYW
1 stop25h 16mMultiple Airlines
Mon 12/2910:01 pmEYW - MLI
1 stop16h 45mMultiple Airlines
Deal found 12/17$317
This Kiwi.com deal was found by Cheapflights users on 12/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 12/232:36 pmMLI - EYW
1 stop15h 31mMultiple Airlines
Sat 12/2710:35 pmEYW - MLI
1 stop10h 22mMultiple Airlines
Deal found 12/17$360
This Kiwi.com deal was found by Cheapflights users on 12/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 12/237:30 amDSM - EYW
2 stops35h 25mAllegiant Air
Sun 12/2810:37 pmEYW - DSM
1 stop18h 03mAllegiant Air
Deal found 12/16$369
This Delta deal was found by Cheapflights users on 12/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 12/222:18 pmDSM - EYW
1 stop6h 16mDelta
Mon 12/2911:47 amEYW - DSM
1 stop6h 28mDelta
Deal found 12/16$374
This Kiwi.com deal was found by Cheapflights users on 12/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 12/2110:14 amMLI - EYW
1 stop25h 16mMultiple Airlines
Sat 12/2710:35 pmEYW - MLI
1 stop10h 22mMultiple Airlines
Deal found 12/17$376
This Kiwi.com deal was found by Cheapflights users on 12/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 12/237:30 amDSM - EYW
2 stops35h 25mAllegiant Air
Mon 12/2910:01 pmEYW - DSM
1 stop26h 00mAllegiant Air
Deal found 12/16$377
This United Airlines deal was found by Cheapflights users on 12/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/248:00 amDSM - EYW
1 stop6h 12mUnited Airlines
Mon 12/294:29 pmEYW - DSM
1 stop7h 01mUnited Airlines
Deal found 12/16$378
This Kiwi.com deal was found by Cheapflights users on 12/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/246:15 amDSM - EYW
1 stop7h 24mAllegiant Air
Sun 12/2810:37 pmEYW - DSM
1 stop18h 03mAllegiant Air
Deal found 12/16$390
This United Airlines deal was found by Cheapflights users on 12/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/246:30 amMLI - EYW
1 stop7h 42mUnited Airlines
Wed 12/314:08 pmEYW - MLI
1 stop6h 13mUnited Airlines
Deal found 12/17$391
This United Airlines deal was found by Cheapflights users on 12/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/248:00 amDSM - EYW
1 stop6h 12mUnited Airlines
Wed 12/314:08 pmEYW - DSM
1 stop6h 32mUnited Airlines
Deal found 12/16$394
This Kiwi.com deal was found by Cheapflights users on 12/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 12/237:30 amDSM - EYW
2 stops35h 25mAllegiant Air
Sat 12/2710:35 pmEYW - DSM
1 stop20h 04mAllegiant Air
Deal found 12/16$401

Find flight deals from Iowa to Key West

Keep the following information in mind while searching for Iowa to Key West flight deals. Data was last updated December 18, 2025.

Most accurate provider

eDreams
3 stars

Most trusted provider

eDreams
3 stars

Round-trip from

$256
(American Airlines)

One-way from

$158
(Kiwi.com)

Popular in

June

Cheapest in

April

Average price

$488
Provider with most accurate pricing for Des Moines-Key West flight deals.
Search Deals
Provider most trusted by Cheapflights users for Des Moines-Key West flights.
Search Deals
From Iowa to Key West
Search Deals
One-way flight from Iowa to Key West
Search Deals
Highest demand for flights based on searches. 12% potential increase in price ($65 potential increase over avg. RT price).
Search Deals
Cheapest flight prices on average. 3% potential price decrease ($14 potential savings vs. average RT price).
Search Deals
Average for round-trip flights in December 2025
Search Deals

Cheapflights Fare Finder

 
Customize your flight search to find flights from Iowa to Key West that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated December 18, 2025.
Use the filters below to find and compare flights from Iowa to Key West that are best for you.

Fly from

Iowa

Fly to

Key West

Route

Depart

Return

Price

Cedar RapidsKey West

CID - EYW

CIDEYW

Cedar Rapids

Wed 1/7

10:08 am-9:47 pm

2 stops10h 39m

Key West

Tue 1/13

6:43 pm-11:05 pm

1 stop5h 22m

$256

OmahaKey West

OMA - EYW

OMAEYW

Omaha Eppley Airfield

Tue 1/20

7:00 am-3:25 pm

1 stop7h 25m

Key West

Mon 1/26

4:37 pm-11:59 pm

1 stop8h 22m

$257

Cedar RapidsKey West

CID - EYW

CIDEYW

Cedar Rapids

Sat 1/17

1:31 pm-11:56 pm

2 stops9h 25m

Key West

Wed 1/21

6:43 pm-11:05 pm

1 stop5h 22m

$275

OmahaKey West

OMA - EYW

OMAEYW

Omaha Eppley Airfield

Wed 1/21

11:00 am-7:40 pm

1 stop7h 40m

Key West

Wed 1/28

7:10 am-1:44 pm

1 stop7h 34m

$283

OmahaKey West

OMA - EYW

OMAEYW

Omaha Eppley Airfield

Thu 2/5

3:07 pm-9:47 pm

1 stop5h 40m

Key West

Tue 2/10

7:08 am-2:14 pm

1 stop8h 06m

$286

OmahaKey West

OMA - EYW

OMAEYW

Omaha Eppley Airfield

Fri 1/30

3:07 pm-9:47 pm

1 stop5h 40m

Key West

Tue 2/3

7:08 am-2:14 pm

1 stop8h 06m

$286

Cedar RapidsKey West

CID - EYW

CIDEYW

Cedar Rapids

Wed 3/25

6:40 am-3:57 pm

1 stop8h 17m

Key West

Wed 4/1

6:47 pm-11:21 pm

1 stop5h 34m

$289

OmahaKey West

OMA - EYW

OMAEYW

Omaha Eppley Airfield

Fri 1/9

3:07 pm-9:47 pm

1 stop5h 40m

Key West

Mon 1/12

4:37 pm-11:59 pm

1 stop8h 22m

$289

MolineKey West

MLI - EYW

MLIEYW

Moline Quad-City

Wed 1/21

11:28 am-9:47 pm

2 stops9h 19m

Key West

Thu 2/5

2:43 pm-9:58 pm

1 stop8h 15m

$291

Des MoinesKey West

DSM - EYW

DSMEYW

Des Moines

Fri 1/30

10:21 am-7:40 pm

2 stops8h 19m

Key West

Fri 2/6

1:28 pm-7:34 pm

1 stop7h 06m

$294

Flights are sorted by cheapest round-trip flights first.

Deals found on 12/15

Showing 1-10 of 40 results
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Best time to book a flight from Iowa to Key West

Have a flexible travel schedule? Discover the best time to fly to Key West from Iowa with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Iowa to Key West

What is the cheapest month to book a flight from Iowa to Key West?

Currently, July is the cheapest month in which you can book a flight from Iowa to Key West (average of $80). Flying from Iowa to Key West in June is currently the most expensive (average of $268). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

Related info for your journey

Find useful and relevant information for your journey from Iowa to Key West. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airport do you fly into for flights to Key West from Iowa?

    Located just 2.6 mi from the city center, Key West (EYW) is the airport most travelers will use when flying to Key West from Iowa.

  • How long is the flight from Iowa to Key West?

    Airlines like American Airlines and Delta fly from Iowa to Key West in about 8h 19m. The time it takes to get you to your destination can typically vary by up to 2h 20m. The distance between Iowa and Key West is about 1357 mi. This flight may include one or multiple stops.

  • What are the most popular routes from Iowa to Key West?

    While some choose either Des Moines - Key West or Cedar Rapids - Key West, Omaha Eppley Airfield - Key West is the most popular route from Iowa to Key West.

  • Can I find deals for flights from Iowa to Key West that include hotel bookings?

    Yes. In addition to deals on Iowa to Key West flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Iowa to Key West?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Iowa to Key West.

  • Can I find deals for business class flights from Iowa to Key West?

    Yes. Cheapflights offers flight deals from Iowa to Key West by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Iowa to Key West?

    Currently, July is the cheapest month in which you can book a flight from Iowa to Key West (average of $80). Flying from Iowa to Key West in June is currently the most expensive (average of $268). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

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Alternative routes for Iowa to Key West

See prices for flight routes from nearby airports that may be better suited for you.
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Top 4 airlines flying from Iowa to Key West

Discover the top 4 airlines that operate flights from Iowa to Key West. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated December 18, 2025.
AirlineCheapestAverageFlexibilityOn-time
Allegiant AirCheapest$76Average$157FlexibilityNo cancel feeOn-time88%
United AirlinesCheapest$230Average$597FlexibilityNo cancel feeOn-time69%
American AirlinesCheapest$259Average$477FlexibilityNo cancel feeOn-time71%
DeltaCheapest$268Average$423FlexibilityNo cancel feeOn-timeN/A

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