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Key West

$225+ Cheap flights from Iowa to Key West (EYW)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 11/14. Fares are subject to change and may not be available on all flights or dates of travel.
DSM — EYW
Nov 29 — Dec 61
Sat 11/29
Sat 12/6
1 adult, Economy
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Find flight deals from Iowa to Key West

Cheapest flights from Iowa to Key West
Explore the most affordable flight options available from Iowa to Key West. Find the lowest fares from popular airlines and budget airlines, with prices last updated on October 30, 2025.

This American Airlines deal was found by Cheapflights users on 10/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/179:23 amOMA - EYW
1 stop5h 44mAmerican Airlines
Sun 12/214:40 pmEYW - OMA
1 stop8h 19mAmerican Airlines
Deal found 10/30$269
This Delta deal was found by Cheapflights users on 10/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 12/611:23 amDSM - EYW
1 stop7h 43mDelta
Sat 12/136:10 pmEYW - DSM
1 stop5h 24mDelta
Deal found 10/29$269
This American Airlines deal was found by Cheapflights users on 10/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 12/65:35 amDSM - EYW
2 stops9h 37mAmerican Airlines
Sat 12/138:00 amEYW - DSM
1 stop6h 19mAmerican Airlines
Deal found 10/30$274
This American Airlines deal was found by Cheapflights users on 10/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 12/156:00 amOMA - EYW
2 stops9h 57mAmerican Airlines
Thu 1/156:06 amEYW - OMA
2 stops11h 44mAmerican Airlines
Deal found 10/29$279
This Kiwi.com deal was found by Cheapflights users on 10/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 12/1310:38 amDSM - EYW
1 stop28h 06mAllegiant Air
Sat 12/203:36 pmEYW - DSM
1 stop8h 56mAllegiant Air
Deal found 10/29$281
This Kiwi.com deal was found by Cheapflights users on 10/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 12/72:18 pmOMA - EYW
2 stops17h 59mMultiple Airlines
Thu 12/1110:27 pmEYW - OMA
1 stop12h 51mMultiple Airlines
Deal found 10/29$285
This American Airlines deal was found by Cheapflights users on 10/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 12/611:29 amCID - EYW
2 stops9h 21mAmerican Airlines
Sat 12/134:20 pmEYW - CID
1 stop8h 22mAmerican Airlines
Deal found 10/28$290
This Kiwi.com deal was found by Cheapflights users on 10/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 11/126:37 pmCID - EYW
1 stop25h 09mAllegiant Air
Wed 11/193:58 pmEYW - CID
1 stop17h 25mAllegiant Air
Deal found 10/30$300
This Kiwi.com deal was found by Cheapflights users on 10/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/311:17 amCID - EYW
1 stop27h 27mAllegiant Air
Thu 12/1110:27 pmEYW - CID
1 stop20h 15mAllegiant Air
Deal found 10/28$305
This Kiwi.com deal was found by Cheapflights users on 10/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/187:28 pmMLI - EYW
1 stop21h 45mAllegiant Air
Mon 12/2910:01 pmEYW - MLI
1 stop16h 45mAllegiant Air
Deal found 10/30$311
This Kiwi.com deal was found by Cheapflights users on 10/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 12/216:13 pmMLI - EYW
1 stop20h 53mAllegiant Air
Mon 12/2910:01 pmEYW - MLI
1 stop16h 45mAllegiant Air
Deal found 10/30$312
This American Airlines deal was found by Cheapflights users on 10/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/202:02 pmCID - EYW
1 stop6h 45mAmerican Airlines
Wed 12/31:51 pmEYW - CID
1 stop7h 33mAmerican Airlines
Deal found 10/30$334

Cheap flight deals from Iowa to Key West

Keep the following information in mind while searching for Iowa to Key West flight deals. Data was last updated October 30, 2025.

Most accurate provider

eDreams
3 stars

Most trusted provider

eDreams
3 stars

Round-trip from

$251
(Kiwi.com)

One-way from

$225
(Kiwi.com)

Popular in

June

Cheapest in

April

Average price

$398
Provider with most accurate pricing for Des Moines-Key West flight deals.
Search Deals
Provider most trusted by Cheapflights users for Des Moines-Key West flights.
Search Deals
From Iowa to Key West
Search Deals
One-way flight from Iowa to Key West
Search Deals
Highest demand for flights based on searches. 15% potential increase in price ($81 potential increase over avg. RT price).
Search Deals
Cheapest flight prices on average. 3% potential price decrease ($14 potential savings vs. average RT price).
Search Deals
Average for round-trip flights in October 2025
Search Deals

Cheapflights Fare Finder

 
Customize your flight search to find flights from Iowa to Key West that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated October 30, 2025.
Use the filters below to find and compare flights from Iowa to Key West that are best for you.

Fly from

Iowa

Fly to

Key West

Route

Depart

Return

Price

Cedar RapidsKey West

CID - EYW

CIDEYW

Cedar Rapids

Wed 1/7

6:25 am-4:49 pm

2 stops9h 24m

Key West

Tue 1/13

4:01 pm-10:15 pm

1 stop7h 14m

$256

Des MoinesKey West

DSM - EYW

DSMEYW

Des Moines

Sat 12/6

11:23 am-8:06 pm

1 stop7h 43m

Key West

Sat 12/13

6:10 pm-10:34 pm

1 stop5h 24m

$269

OmahaKey West

OMA - EYW

OMAEYW

Omaha Eppley Airfield

Tue 2/17

3:03 pm-10:24 pm

1 stop6h 21m

Key West

Wed 2/25

8:14 am-2:13 pm

1 stop6h 59m

$269

OmahaKey West

OMA - EYW

OMAEYW

Omaha Eppley Airfield

Mon 12/15

5:07 am-2:07 pm

1 stop8h 00m

Key West

Thu 1/15

1:28 pm-10:34 pm

1 stop10h 06m

$269

OmahaKey West

OMA - EYW

OMAEYW

Omaha Eppley Airfield

Wed 11/19

3:10 pm-9:48 pm

1 stop5h 38m

Key West

Mon 11/24

4:55 pm-11:59 pm

1 stop8h 04m

$269

MolineKey West

MLI - EYW

MLIEYW

Moline Quad-City

Wed 1/7

5:51 am-11:31 am

1 stop4h 40m

Key West

Tue 1/13

6:08 pm-10:32 pm

1 stop5h 24m

$269

MolineKey West

MLI - EYW

MLIEYW

Moline Quad-City

Wed 1/21

6:00 am-4:24 pm

1 stop9h 24m

Key West

Thu 2/5

4:01 pm-10:23 pm

1 stop7h 22m

$269

OmahaKey West

OMA - EYW

OMAEYW

Omaha Eppley Airfield

Wed 12/17

6:00 am-5:52 pm

2 stops10h 52m

Key West

Sun 12/21

8:00 am-1:13 pm

1 stop6h 13m

$274

OmahaKey West

OMA - EYW

OMAEYW

Omaha Eppley Airfield

Thu 1/29

3:07 pm-9:47 pm

1 stop5h 40m

Key West

Wed 2/4

1:33 pm-10:56 pm

2 stops10h 23m

$274

MolineKey West

MLI - EYW

MLIEYW

Moline Quad-City

Tue 2/17

6:15 am-3:56 pm

1 stop8h 41m

Key West

Wed 2/25

11:47 am-9:05 pm

2 stops10h 18m

$274

Flights are sorted by cheapest round-trip flights first.

Deals found on 10/29

Showing 1-10 of 42 results
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Best time to book a flight from Iowa to Key West

Have a flexible travel schedule? Discover the best time to fly to Key West from Iowa with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Iowa to Key West

What is the cheapest month to book a flight from Iowa to Key West?

Currently, July is the cheapest month in which you can book a flight from Iowa to Key West (average of $82). Flying from Iowa to Key West in March is currently the most expensive (average of $279). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

How much does it cost to fly round-trip from Iowa to Key West?

Related info for your journey

Find useful and relevant information for your journey from Iowa to Key West. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airport do you fly into for flights to Key West from Iowa?

    Located just 2.6 mi from the city center, Key West (EYW) is the airport most travelers will use when flying to Key West from Iowa.

  • How long is the flight from Iowa to Key West?

    Airlines like American Airlines, Delta, and Allegiant Air fly from Iowa to Key West in about 7h 43m. The time it takes to get you to your destination can typically vary by up to 20h 23m. The distance between Iowa and Key West is about 1357 mi. This flight may include one or multiple stops.

  • What are the cheapest airlines to fly from Iowa to Key West one-way?

    $255 is the cheapest one-way deal found within the past few days, from American Airlines. You may also be able to find cheap deals on United Airlines and Delta, with prices starting from $295 and $350, respectively.

  • What are the most popular routes from Iowa to Key West?

    While some choose either Des Moines - Key West or Omaha Eppley Airfield - Key West, Cedar Rapids - Key West is the most popular route from Iowa to Key West.

  • Can I find deals for flights from Iowa to Key West that include hotel bookings?

    Yes. In addition to deals on Iowa to Key West flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Iowa to Key West?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Iowa to Key West.

  • Can I find deals for business class flights from Iowa to Key West?

    Yes. Cheapflights offers flight deals from Iowa to Key West by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Iowa to Key West?

    Currently, July is the cheapest month in which you can book a flight from Iowa to Key West (average of $82). Flying from Iowa to Key West in March is currently the most expensive (average of $279). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

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Top 4 airlines flying from Iowa to Key West

Discover the top 4 airlines that operate flights from Iowa to Key West. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated October 30, 2025.
AirlineCheapestAverageFlexibilityOn-time
Allegiant AirCheapest$76Average$157FlexibilityNo cancel feeOn-time88%
American AirlinesCheapest$259Average$464FlexibilityNo cancel feeOn-time71%
DeltaCheapest$268Average$416FlexibilityNo cancel feeOn-timeN/A
United AirlinesCheapest$304Average$548FlexibilityNo cancel feeOn-time69%

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