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Key West

$164+ Cheap flights from Iowa to Key West (EYW)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 5/26. Fares are subject to change and may not be available on all flights or dates of travel.
DSM — EYW
Apr 29 — May 61
Wed 4/29
Wed 5/6
1 adult, Economy
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Cheap flight deals from Iowa to Key West

Cheapest flights from Iowa to Key West
Explore the most affordable flight options available from Iowa to Key West. Find the lowest fares from popular airlines and budget airlines, with prices last updated on March 30, 2026.

This Kiwi.com deal was found by Cheapflights users on 3/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 7/410:06 am
MLI
-
EYW
1 stop28h 21m
Allegiant Air
Fri 7/103:27 pm
EYW
-
MLI
1 stop17h 20m
Allegiant Air
Deal found 3/29$241
This Kiwi.com deal was found by Cheapflights users on 3/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 7/47:20 pm
CID
-
EYW
1 stop19h 07m
Allegiant Air
Thu 7/98:48 pm
EYW
-
CID
1 stop12h 14m
Allegiant Air
Deal found 3/29$262
This Kiwi.com deal was found by Cheapflights users on 3/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 4/255:17 pm
MLI
-
EYW
1 stop21h 31m
Allegiant Air
Sat 5/211:54 am
EYW
-
MLI
1 stop21h 40m
Allegiant Air
Deal found 3/27$268
This Kiwi.com deal was found by Cheapflights users on 3/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 4/1111:00 am
DSM
-
EYW
1 stop27h 00m
Multiple Airlines
Wed 4/1512:39 pm
EYW
-
DSM
2 stops28h 21m
Multiple Airlines
Deal found 3/26$272
This Kiwi.com deal was found by Cheapflights users on 3/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 4/255:17 pm
MLI
-
EYW
1 stop21h 31m
Allegiant Air
Wed 4/2912:39 pm
EYW
-
MLI
1 stop20h 55m
Allegiant Air
Deal found 3/28$272
This Kiwi.com deal was found by Cheapflights users on 3/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 4/115:22 pm
MLI
-
EYW
1 stop20h 38m
Allegiant Air
Wed 4/1512:39 pm
EYW
-
MLI
1 stop20h 15m
Allegiant Air
Deal found 3/26$274
This American Airlines deal was found by Cheapflights users on 3/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 5/612:48 pm
CID
-
EYW
2 stops9h 10m
American Airlines
Sat 5/166:46 pm
EYW
-
CID
1 stop5h 59m
American Airlines
Deal found 3/28$286
This Kiwi.com deal was found by Cheapflights users on 3/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 7/47:20 pm
CID
-
EYW
1 stop19h 07m
Allegiant Air
Fri 7/104:41 pm
EYW
-
CID
1 stop26h 49m
Allegiant Air
Deal found 3/29$288
This American Airlines deal was found by Cheapflights users on 3/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 4/2511:09 am
DSM
-
EYW
1 stop6h 07m
American Airlines
Wed 4/296:46 pm
EYW
-
DSM
1 stop6h 03m
American Airlines
Deal found 3/26$289
This Kiwi.com deal was found by Cheapflights users on 3/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 7/47:20 pm
CID
-
EYW
1 stop19h 07m
Allegiant Air
Wed 7/85:10 pm
EYW
-
CID
1 stop26h 24m
Allegiant Air
Deal found 3/29$293
This Kiwi.com deal was found by Cheapflights users on 3/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 7/57:24 pm
CID
-
EYW
1 stop19h 27m
Allegiant Air
Thu 7/98:48 pm
EYW
-
CID
1 stop12h 14m
Allegiant Air
Deal found 3/29$294
This Kiwi.com deal was found by Cheapflights users on 3/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 7/43:20 pm
DSM
-
EYW
1 stop26h 56m
Multiple Airlines
Thu 7/97:56 pm
EYW
-
DSM
1 stop27h 19m
Multiple Airlines
Deal found 3/27$297

Find flight deals from Iowa to Key West

Keep the following information in mind while searching for Iowa to Key West flight deals. Data was last updated March 30, 2026.

Most accurate provider

FlightHub
3 stars

Most trusted provider

FlightHub
3 stars

Round-trip from

$241
(Kiwi.com)

One-way from

$164
(Kiwi.com)

Popular in

February

Cheapest in

September

Average price

$468
Provider with most accurate pricing for Des Moines-Key West flight deals.
Search Deals
Provider most trusted by Cheapflights users for Des Moines-Key West flights.
Search Deals
From Iowa to Key West
Search Deals
One-way flight from Iowa to Key West
Search Deals
Highest demand for flights based on searches. 17% potential increase in price ($94 potential increase over avg. RT price).
Search Deals
Cheapest flight prices on average. 3% potential price decrease ($16 potential savings vs. average RT price).
Search Deals
Average for round-trip flights in March 2026
Search Deals

Cheapflights Fare Finder

 
Customize your flight search to find flights from Iowa to Key West that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated March 30, 2026.
Use the filters below to find and compare flights from Iowa to Key West that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Cheapest round-trip

Des MoinesKey West

DSM - EYW

DSMEYW

Des Moines

Sat 4/25

11:09 am-10:36 pm

2 stops10h 27m

Key West

Wed 4/29

4:20 pm-10:18 pm

1 stop6h 58m

$324

OmahaKey West

OMA - EYW

OMAEYW

Omaha Eppley Airfield

Tue 4/21

11:39 am-7:40 pm

1 stop7h 01m

Key West

Thu 4/30

6:23 pm-12:10 am

1 stop6h 47m

$349

Des MoinesKey West

DSM - EYW

DSMEYW

Des Moines

Sat 5/2

8:15 am-4:02 pm

1 stop6h 47m

Key West

Tue 5/5

4:47 pm-10:45 pm

1 stop6h 58m

$351

OmahaKey West

OMA - EYW

OMAEYW

Omaha Eppley Airfield

Tue 4/21

12:13 pm-9:53 pm

2 stops8h 40m

Key West

Thu 4/30

4:20 pm-12:22 am

1 stop9h 02m

$354

MolineKey West

MLI - EYW

MLIEYW

Moline Quad-City

Thu 4/16

12:52 pm-10:58 pm

2 stops9h 06m

Key West

Thu 4/23

3:58 pm-11:54 pm

2 stops8h 56m

$359

OmahaKey West

OMA - EYW

OMAEYW

Omaha Eppley Airfield

Sat 4/18

12:13 pm-10:36 pm

2 stops9h 23m

Key West

Tue 4/21

3:58 pm-11:32 pm

2 stops8h 34m

$361

MolineKey West

MLI - EYW

MLIEYW

Moline Quad-City

Tue 5/26

6:00 am-4:07 pm

2 stops9h 07m

Key West

Tue 6/2

1:39 pm-10:02 pm

2 stops9h 23m

$361

Des MoinesKey West

DSM - EYW

DSMEYW

Des Moines

Wed 4/15

11:51 am-7:40 pm

1 stop6h 49m

Key West

Wed 4/22

7:33 am-1:55 pm

1 stop7h 22m

$368

Des MoinesKey West

DSM - EYW

DSMEYW

Des Moines

Sat 4/11

8:04 am-2:51 pm

1 stop5h 47m

Key West

Wed 4/15

4:38 pm-10:43 pm

1 stop7h 05m

$374

OmahaKey West

OMA - EYW

OMAEYW

Omaha Eppley Airfield

Wed 4/15

5:30 am-1:44 pm

1 stop7h 14m

Key West

Wed 4/22

6:23 pm-12:10 am

1 stop6h 47m

$374

Flights are sorted by cheapest round-trip flights first.

Deals found on 3/26

Showing 1-10 of 52 resultsSorted by cheapest first
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Best time to book a flight from Iowa to Key West

Have a flexible travel schedule? Discover the best time to fly to Key West from Iowa with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Iowa to Key West

What is the cheapest month to book a flight from Iowa to Key West?

Currently, July is the cheapest month in which you can book a flight from Iowa to Key West (average of $76). Flying from Iowa to Key West in December is currently the most expensive (average of $321). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

How much does it cost to fly round-trip from Iowa to Key West?

Related info for your journey

Find useful and relevant information for your journey from Iowa to Key West. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airport do you fly into for flights to Key West from Iowa?

    Located just 2.6 mi from the city center, Key West (EYW) is the airport most travelers will use when flying to Key West from Iowa.

  • How long is the flight from Iowa to Key West?

    Airlines like American Airlines, Delta, and United Airlines fly from Iowa to Key West in about 6h 47m. The time it takes to get you to your destination can typically vary by up to 3h 40m. The distance between Iowa and Key West is about 1357 mi. This flight may include one or multiple stops.

  • What are the most popular routes from Iowa to Key West?

    While some choose either Moline Quad-City - Key West or Cedar Rapids - Key West, Des Moines - Key West is the most popular route from Iowa to Key West.

  • Can I find deals for flights from Iowa to Key West that include hotel bookings?

    Yes. In addition to deals on Iowa to Key West flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Iowa to Key West?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Iowa to Key West.

  • Can I find deals for business class flights from Iowa to Key West?

    Yes. Cheapflights offers flight deals from Iowa to Key West by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Iowa to Key West?

    Currently, July is the cheapest month in which you can book a flight from Iowa to Key West (average of $76). Flying from Iowa to Key West in December is currently the most expensive (average of $321). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

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Alternative routes for Iowa to Key West

See prices for flight routes from nearby airports that may be better suited for you.
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Top 4 airlines flying from Iowa to Key West

Discover the top 4 airlines that operate flights from Iowa to Key West. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated March 30, 2026.
AirlineCheapestAverageFlexibilityOn-time
Allegiant AirCheapest$76Average$174FlexibilityNo cancel feeOn-time88%
United AirlinesCheapest$230Average$408FlexibilityNo cancel feeOn-time69%
DeltaCheapest$243Average$388FlexibilityNo cancel feeOn-timeN/A
American AirlinesCheapest$259Average$458FlexibilityNo cancel feeOn-time71%

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