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Key West

$269+ Cheap flights from Iowa to Key West (EYW)

This is the cheapest round-trip flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 10/14. Fares are subject to change and may not be available on all flights or dates of travel.
DSM — EYW
Oct 16 — Oct 231
Thu 10/16
Thu 10/23
1 adult, Economy
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Cheap flight deals from Iowa to Key West

Keep the following information in mind while searching for Iowa to Key West flight deals. Data was last updated September 16, 2025.

Round-trip from

$251
(American Airlines)

Popular in

June

Cheapest in

April

Average price

$348
From Iowa to Key West
Search Deals
Highest demand for flights based on searches. 16% potential increase in price ($90 potential increase over avg. RT price).
Search Deals
Cheapest flight prices on average. 3% potential price decrease ($13 potential savings vs. average RT price).
Search Deals
Average for round-trip flights in September 2025
Search Deals

Find flight deals from Iowa to Key West

Cheapest flights from Iowa to Key West
Explore the most affordable flight options available from Iowa to Key West. Find the lowest fares from popular airlines and budget airlines, with prices last updated on September 16, 2025.

This Delta deal was found by Cheapflights users on 9/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 10/145:47 amDSM - EYW
1 stop4h 40mDelta
Wed 10/226:17 pmEYW - DSM
1 stop5h 13mDelta
Deal found 9/15$269
This American Airlines deal was found by Cheapflights users on 9/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 10/145:00 amDSM - EYW
2 stops11h 16mAmerican Airlines
Tue 10/2111:22 amEYW - DSM
2 stops9h 49mAmerican Airlines
Deal found 9/14$279
This American Airlines deal was found by Cheapflights users on 9/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 11/89:21 amOMA - EYW
2 stops11h 28mAmerican Airlines
Wed 11/127:31 amEYW - OMA
1 stop7h 39mAmerican Airlines
Deal found 9/14$288
This American Airlines deal was found by Cheapflights users on 9/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 9/305:09 amCID - EYW
2 stops12h 50mAmerican Airlines
Tue 10/74:37 pmEYW - CID
1 stop7h 33mAmerican Airlines
Deal found 9/14$290
This Delta deal was found by Cheapflights users on 9/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/32:05 pmDSM - EYW
1 stop5h 02mDelta
Tue 10/712:22 pmEYW - DSM
1 stop6h 22mDelta
Deal found 9/15$294
This Kiwi.com deal was found by Cheapflights users on 9/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 12/126:32 pmCID - EYW
1 stop21h 24mMultiple Airlines
Mon 12/158:55 amEYW - CID
1 stop10h 52mMultiple Airlines
Deal found 9/15$297
This American Airlines deal was found by Cheapflights users on 9/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/37:00 amDSM - EYW
2 stops10h 59mAmerican Airlines
Tue 10/72:14 pmEYW - DSM
2 stops10h 02mAmerican Airlines
Deal found 9/14$304
This American Airlines deal was found by Cheapflights users on 9/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 11/113:18 pmDSM - EYW
1 stop5h 30mAmerican Airlines
Sat 11/158:00 amEYW - DSM
1 stop6h 31mAmerican Airlines
Deal found 9/15$306
This American Airlines deal was found by Cheapflights users on 9/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 11/19:00 amDSM - EYW
2 stops11h 56mAmerican Airlines
Tue 11/44:18 pmEYW - DSM
1 stop8h 20mAmerican Airlines
Deal found 9/14$311
This Delta deal was found by Cheapflights users on 9/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 9/305:57 amCID - EYW
1 stop6h 05mDelta
Tue 10/76:17 pmEYW - CID
1 stop5h 17mDelta
Deal found 9/15$315
This Delta deal was found by Cheapflights users on 9/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 9/2711:25 amDSM - EYW
1 stop7h 42mDelta
Wed 10/16:10 pmEYW - DSM
1 stop5h 27mDelta
Deal found 9/13$319
This American Airlines deal was found by Cheapflights users on 9/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 9/238:19 amMLI - EYW
1 stop5h 55mAmerican Airlines
Tue 9/306:17 pmEYW - MLI
1 stop5h 08mAmerican Airlines
Deal found 9/14$334

Cheapflights Fare Finder

 
Customize your flight search to find flights from Iowa to Key West that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated September 16, 2025.
Use the filters below to find and compare flights from Iowa to Key West that are best for you.

Fly from

Iowa

Fly to

Key West

Route

Depart

Return

Price

Des MoinesKey West

DSM - EYW

DSMEYW

Des Moines

Tue 10/14

2:13 pm-8:06 pm

1 stop4h 53m

Key West

Wed 10/22

12:22 pm-5:44 pm

1 stop6h 22m

$269

Des MoinesKey West

DSM - EYW

DSMEYW

Des Moines

Sat 12/6

2:08 pm-9:50 pm

1 stop6h 42m

Key West

Sat 12/13

4:59 pm-10:59 pm

1 stop7h 00m

$269

Des MoinesKey West

DSM - EYW

DSMEYW

Des Moines

Tue 10/14

2:13 pm-8:06 pm

1 stop4h 53m

Key West

Tue 10/21

6:17 pm-10:30 pm

1 stop5h 13m

$269

MolineKey West

MLI - EYW

MLIEYW

Moline Quad-City

Wed 1/7

6:13 am-3:29 pm

1 stop8h 16m

Key West

Tue 1/13

4:00 pm-9:28 pm

1 stop6h 28m

$269

Des MoinesKey West

DSM - EYW

DSMEYW

Des Moines

Tue 10/14

7:00 am-2:46 pm

1 stop6h 46m

Key West

Tue 10/21

4:37 pm-12:02 am

2 stops8h 25m

$274

Des MoinesKey West

DSM - EYW

DSMEYW

Des Moines

Wed 12/3

12:57 pm-11:07 pm

2 stops9h 10m

Key West

Tue 12/9

7:00 am-2:51 pm

2 stops8h 51m

$279

OmahaKey West

OMA - EYW

OMAEYW

Omaha Eppley Airfield

Sat 11/8

9:21 am-9:49 pm

2 stops11h 28m

Key West

Wed 11/12

7:31 am-2:10 pm

1 stop7h 39m

$288

Cedar RapidsKey West

CID - EYW

CIDEYW

Cedar Rapids

Tue 9/30

5:09 am-6:59 pm

2 stops12h 50m

Key West

Tue 10/7

4:37 pm-11:10 pm

1 stop7h 33m

$290

Cedar RapidsKey West

CID - EYW

CIDEYW

Cedar Rapids

Tue 9/30

5:57 am-1:02 pm

1 stop6h 05m

Key West

Tue 10/7

6:17 pm-10:34 pm

1 stop5h 17m

$315

OmahaKey West

OMA - EYW

OMAEYW

Omaha Eppley Airfield

Mon 11/17

6:15 am-7:23 pm

2 stops12h 08m

Key West

Sat 11/22

4:55 pm-11:59 pm

1 stop8h 04m

$343

Flights are sorted by cheapest round-trip flights first.

Deals found on 9/14

Showing 1-10 of 34 results
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Best time to book a flight from Iowa to Key West

Have a flexible travel schedule? Discover the best time to fly to Key West from Iowa with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Iowa to Key West

What is the cheapest month to book a flight from Iowa to Key West?

Currently, August is the cheapest month in which you can book a flight from Iowa to Key West (average of $328). Flying from Iowa to Key West in March is currently the most expensive (average of $491). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

Related info for your journey

Find useful and relevant information for your journey from Iowa to Key West. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airport do you fly into for flights to Key West from Iowa?

    Located just 2.6 mi from the city center, Key West (EYW) is the airport most travelers will use when flying to Key West from Iowa.

  • How long is the flight from Iowa to Key West?

    Airlines like Delta and American Airlines fly from Iowa to Key West in about 4h 53m. The time it takes to get you to your destination can typically vary by up to 3h 23m. The distance between Iowa and Key West is about 1357 mi. This flight may include one or multiple stops.

  • What are the cheapest airlines to fly from Iowa to Key West one-way?

    $300 is the cheapest one-way deal found within the past few days, from American Airlines. You may also be able to find cheap deals on United Airlines and Delta, with prices starting from $385 and $389, respectively.

  • What are the most popular routes from Iowa to Key West?

    While some choose either Omaha Eppley Airfield - Key West or Cedar Rapids - Key West, Des Moines - Key West is the most popular route from Iowa to Key West.

  • Can I find deals for flights from Iowa to Key West that include hotel bookings?

    Yes. In addition to deals on Iowa to Key West flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Iowa to Key West?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Iowa to Key West.

  • Can I find deals for business class flights from Iowa to Key West?

    Yes. Cheapflights offers flight deals from Iowa to Key West by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Iowa to Key West?

    Currently, August is the cheapest month in which you can book a flight from Iowa to Key West (average of $328). Flying from Iowa to Key West in March is currently the most expensive (average of $491). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Browse thousands of different options on Cheapflights for your next trip

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Alternative routes for Iowa to Key West

See prices for flight routes from nearby airports that may be better suited for you.
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Top 4 airlines flying from Iowa to Key West

Discover the top 4 airlines that operate flights from Iowa to Key West. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated September 16, 2025.
AirlineCheapestAverageFlexibilityOn-time
Allegiant AirCheapest$76Average$157FlexibilityNo cancel feeOn-time88%
American AirlinesCheapest$259Average$455FlexibilityNo cancel feeOn-time71%
DeltaCheapest$268Average$425FlexibilityNo cancel feeOn-timeN/A
United AirlinesCheapest$281Average$548FlexibilityNo cancel feeOn-time69%

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