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Key Largo

$242+ Cheap flights from Columbia, MO (COU) to Key Largo, FL

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 5/12. Fares are subject to change and may not be available on all flights or dates of travel.
COU — MIA
May 9 — May 161
Sat 5/9
Sat 5/16
1 adult, Economy
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Cheap flight deals from Columbia to Key Largo

Cheapest flights from Columbia to Key Largo
Explore the most affordable flight options available from Columbia to Key Largo. Find the lowest fares from popular airlines and budget airlines, with prices last updated on April 9, 2026.

This American Airlines deal was found by Cheapflights users on 4/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 4/256:00 am
COU
-
MIA
1 stop6h 59m
American Airlines
Wed 4/296:05 am
MIA
-
COU
1 stop6h 30m
American Airlines
Deal found 4/4$328
This United Airlines deal was found by Cheapflights users on 4/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 5/63:10 pm
COU
-
MIA
1 stop6h 23m
United Airlines
Wed 5/137:40 pm
MIA
-
COU
1 stop6h 08m
United Airlines
Deal found 4/8$348
This American Airlines deal was found by Cheapflights users on 4/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 4/155:21 pm
COU
-
MIA
1 stop6h 11m
American Airlines
Sat 4/185:05 am
MIA
-
COU
1 stop7h 30m
American Airlines
Deal found 4/4$413
This United Airlines deal was found by Cheapflights users on 4/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 5/59:00 am
COU
-
MIA
1 stop9h 59m
United Airlines
Sat 5/94:20 pm
MIA
-
COU
1 stop6h 43m
United Airlines
Deal found 4/4$418
This United Airlines deal was found by Cheapflights users on 4/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 4/153:23 pm
COU
-
MIA
1 stop6h 22m
United Airlines
Sat 4/189:00 am
MIA
-
COU
2 stops13h 03m
United Airlines
Deal found 4/4$419
This United Airlines deal was found by Cheapflights users on 4/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 4/258:00 am
COU
-
MIA
2 stops11h 58m
United Airlines
Wed 4/299:00 am
MIA
-
COU
2 stops13h 03m
United Airlines
Deal found 4/4$429
This United Airlines deal was found by Cheapflights users on 4/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 5/25:00 am
COU
-
MIA
1 stop5h 37m
United Airlines
Wed 5/67:40 pm
MIA
-
COU
1 stop6h 08m
United Airlines
Deal found 4/7$438

Find flight deals from Columbia to Key Largo

Keep the following information in mind while searching for Columbia to Key Largo flight deals. Data was last updated April 9, 2026.

Most accurate provider

FlightHub
3 stars

Most trusted provider

FlightHub
3 stars

Round-trip from

$328
(American Airlines)

One-way from

$242
(American Airlines)

Popular in

December

Cheapest in

February

Average price

$487
Provider with most accurate pricing for Columbia Regional-Miami flight deals.
Search Deals
Provider most trusted by Cheapflights users for Columbia Regional-Miami flights.
Search Deals
From Columbia Regional to Key Largo
Search Deals
One-way flight from Columbia Regional to Key Largo
Search Deals
Highest demand for flights based on searches. 17% potential increase in price ($106 potential increase over avg. RT price).
Search Deals
Cheapest flight prices on average. 4% potential price decrease ($21 potential savings vs. average RT price).
Search Deals
Average for round-trip flights in April 2026
Search Deals

Cheapflights Fare Finder

 
Customize your flight search to find flights from Columbia to Key Largo that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated April 9, 2026.
Use the filters below to find and compare flights from Columbia to Key Largo that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Cheapest round-trip

ColumbiaMiami

COU - MIA

COUMIA

Columbia Regional

Wed 5/6

3:10 pm-10:33 pm

1 stop6h 23m

Miami

Wed 5/13

7:40 pm-12:48 am

1 stop6h 08m

$348

ColumbiaMiami

COU - MIA

COUMIA

Columbia Regional

Tue 5/5

9:00 am-7:59 pm

1 stop9h 59m

Miami

Sat 5/9

4:20 pm-10:03 pm

1 stop6h 43m

$418

ColumbiaMiami

COU - MIA

COUMIA

Columbia Regional

Sat 4/25

8:00 am-8:58 pm

2 stops11h 58m

Miami

Wed 4/29

9:00 am-9:03 pm

2 stops13h 03m

$429
Quickest round-trip

ColumbiaMiami

COU - MIA

COUMIA

Columbia Regional

Sat 5/2

5:00 am-11:37 am

1 stop5h 37m

Miami

Wed 5/6

7:40 pm-12:48 am

1 stop6h 08m

$438

ColumbiaMiami

COU - MIA

COUMIA

Columbia Regional

Wed 7/29

7:16 am-3:38 pm

1 stop7h 22m

Miami

Mon 8/3

10:05 am-4:47 pm

1 stop7h 42m

$464

ColumbiaMiami

COU - MIA

COUMIA

Columbia Regional

Wed 9/2

8:00 am-11:39 pm

2 stops14h 39m

Miami

Sat 9/5

1:34 pm-9:49 pm

2 stops9h 15m

$511
Cheapest one-way
Quickest one-way

ColumbiaMiami

COU - MIA

COUMIA

Columbia Regional

Tue 9/15

12:00 pm-7:55 pm

1 stop6h 55m

$275

ColumbiaMiami

COU - MIA

COUMIA

Columbia Regional

Tue 5/12

8:00 am-4:16 pm

2 stops31h 16m

$348

ColumbiaMiami

COU - MIA

COUMIA

Columbia Regional

Tue 9/15

3:05 pm-3:43 pm

3 stops23h 38m

$578

Flights are sorted by cheapest round-trip flights first.

Deals found on 4/5

Sorted by cheapest first

Best time to book a flight from Columbia to Key Largo

Have a flexible travel schedule? Discover the best time to fly to Key Largo from Columbia with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Columbia to Key Largo

What is the cheapest month to book a flight from Columbia, Missouri to Key Largo?

Currently, February is the cheapest month in which you can book a flight from Columbia, Missouri to Key Largo (average of $268). Flying from Columbia, Missouri to Key Largo in November is currently the most expensive (average of $725). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

How much does it cost to fly round-trip from Columbia, Missouri to Key Largo?

Reviews of airlines servicing Key Largo

Get insights into the airlines that provide service to Key Largo. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Key Largo. Reviews last updated April 9, 2026.
See what other customers who have flown with United Airlines and American Airlines from Columbia to Key Largo have to say. You can also see how each airline compares in terms of entertainment options, comfort, food, crew/service, and boarding process.
United Airlines
7.4
Good
9,554 reviews

Crew

8.1

Food

6.6

Overall

7.4

Boarding

7.7

Comfort

7.3

Entertainment

7.1

Reviews

1 / 20
10.0
Excellent

Dane,Jan 2026

TYS - IAD

It was a short flight, so no time for amenities. Just glad everything was quick and easy from boarding to arriving at my destination with my family
United Airlines
7.4
Good
9,554 reviews
United Airlines
7.4
Good
9,554 reviews

Crew

8.1

Food

6.6

Overall

7.4

Boarding

7.7

Comfort

7.3

Entertainment

7.1

Reviews

1 / 20
10.0
Excellent

Dane,Jan 2026

TYS - IAD

It was a short flight, so no time for amenities. Just glad everything was quick and easy from boarding to arriving at my destination with my family
American Airlines
7.1
Good
11,559 reviews
United Airlines
7.4
Good
9,554 reviews

Crew

8.1

Food

6.6

Overall

7.4

Boarding

7.7

Comfort

7.3

Entertainment

7.1

Reviews

1 / 20
10.0
Excellent

Dane,Jan 2026

TYS - IAD

It was a short flight, so no time for amenities. Just glad everything was quick and easy from boarding to arriving at my destination with my family

Related info for your journey

Find useful and relevant information for your journey from Columbia to Key Largo. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airport do you fly from for flights from Columbia to Key Largo?

    Columbia Regional (COU), located 11.1 mi from the city center, is the airport you fly out of when you book flights from Columbia to Key Largo. 2 airlines have flights from Columbia Regional to Key Largo on a regular basis. Booking flights from Columbia Regional to Key Largo should not be difficult; the airport handles an average of 0 outbound flights to Key Largo per day.

  • How long is the flight from Columbia, Missouri to Key Largo?

    There are many flights that can get you from Columbia, Missouri to Key Largo in 6h 23m. Fly via United Airlines to get the fastest option. There are 1135 mi between Columbia, Missouri and Key Largo.

  • Can I find deals for flights from Columbia to Key Largo that include hotel bookings?

    Yes. In addition to deals on Columbia to Key Largo flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Columbia to Key Largo?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Columbia to Key Largo.

  • Can I find deals for business class flights from Columbia to Key Largo?

    Yes. Cheapflights offers flight deals from Columbia to Key Largo by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Columbia, Missouri to Key Largo?

    Currently, February is the cheapest month in which you can book a flight from Columbia, Missouri to Key Largo (average of $268). Flying from Columbia, Missouri to Key Largo in November is currently the most expensive (average of $725). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

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Top 2 airlines flying from Columbia to Key Largo

Discover the top 2 airlines that operate flights from Columbia to Key Largo. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated April 9, 2026.
AirlineCheapestAverageFlexibilityOn-time
United AirlinesCheapest$268Average$398FlexibilityNo cancel feeOn-time69%
American AirlinesCheapest$398Average$580FlexibilityNo cancel feeOn-time71%

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