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Key Largo

$285+ Cheap flights from Columbia, MO (COU) to Key Largo, FL

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 1/10. Fares are subject to change and may not be available on all flights or dates of travel.
COU — MIA
Sep 2 — Sep 91
Tue 9/2
Tue 9/9
1 adult, Economy
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Cheap flight deals from Columbia to Key Largo

Keep the following information in mind while searching for Columbia to Key Largo flight deals. Data was last updated August 28, 2025.

Round-trip from

$520
(United Airlines)

One-way from

$285
(American Airlines)

Popular in

May

Cheapest in

September

Average price

$600
From Columbia Regional to Key Largo
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One-way flight from Columbia Regional to Key Largo
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Highest demand for flights based on searches. 8% potential increase in price ($63 potential increase over avg. RT price).
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Cheapest flight prices on average. 3% potential price decrease ($23 potential savings vs. average RT price).
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Average for round-trip flights in August 2025
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Find flight deals from Columbia to Key Largo

Cheapest flights from Columbia to Key Largo
Explore the most affordable flight options available from Columbia to Key Largo. Find the lowest fares from popular airlines and budget airlines, with prices last updated on August 28, 2025.

This United Airlines deal was found by Cheapflights users on 8/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/106:15 pmCOU - MIA
1 stop16h 34mUnited Airlines
Sat 12/137:15 amMIA - COU
2 stops15h 07mUnited Airlines
Deal found 8/26$520
This American Airlines deal was found by Cheapflights users on 8/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/1011:54 amCOU - MIA
1 stop6h 11mAmerican Airlines
Sat 12/136:20 amMIA - COU
1 stop6h 04mAmerican Airlines
Deal found 8/27$550
This American Airlines deal was found by Cheapflights users on 8/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 9/1212:28 pmCOU - MIA
1 stop8h 16mAmerican Airlines
Tue 9/167:02 amMIA - COU
1 stop5h 56mAmerican Airlines
Deal found 8/28$570
This American Airlines deal was found by Cheapflights users on 8/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 9/1112:30 pmCOU - MIA
1 stop7h 08mAmerican Airlines
Mon 9/155:16 pmMIA - COU
1 stop5h 38mAmerican Airlines
Deal found 8/27$630
This American Airlines deal was found by Cheapflights users on 8/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 8/2912:17 pmCOU - MIA
1 stop7h 18mAmerican Airlines
Sun 8/315:55 pmMIA - COU
1 stop5h 34mAmerican Airlines
Deal found 8/27$713

Cheapflights Fare Finder

 
Customize your flight search to find flights from Columbia to Key Largo that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated August 28, 2025.
Use the filters below to find and compare flights from Columbia to Key Largo that are best for you.

Fly from

Columbia

Fly to

Key Largo

Route

Depart

Return

Price

ColumbiaMiami

COU - MIA

COUMIA

Columbia Regional

Wed 12/10

6:15 pm-11:49 am

1 stop16h 34m

Miami

Sat 12/13

7:15 am-9:22 pm

2 stops15h 07m

$520

ColumbiaMiami

COU - MIA

COUMIA

Columbia Regional

Sun 2/22

8:00 am-11:23 am

1 stop26h 23m

Miami

Sat 2/28

7:35 pm-9:10 pm

1 stop26h 35m

$525

ColumbiaMiami

COU - MIA

COUMIA

Columbia Regional

Thu 1/8

8:09 am-9:54 pm

2 stops12h 45m

Miami

Mon 1/12

6:25 pm-9:37 pm

2 stops28h 12m

$535

ColumbiaMiami

COU - MIA

COUMIA

Columbia Regional

Wed 12/10

12:09 pm-9:43 pm

1 stop8h 34m

Miami

Sat 12/13

6:00 am-11:31 am

1 stop6h 31m

$550

ColumbiaMiami

COU - MIA

COUMIA

Columbia Regional

Thu 1/8

5:54 am-4:11 pm

1 stop9h 17m

Miami

Mon 1/12

9:12 am-6:59 pm

1 stop10h 47m

$551

ColumbiaMiami

COU - MIA

COUMIA

Columbia Regional

Sat 1/10

12:08 pm-9:31 pm

1 stop8h 23m

$285

ColumbiaMiami

COU - MIA

COUMIA

Columbia Regional

Sat 1/10

8:09 am-10:20 pm

2 stops13h 11m

$307

Flights are sorted by cheapest round-trip flights first.

Deals found on 8/27

Best time to book a flight from Columbia to Key Largo

Have a flexible travel schedule? Discover the best time to fly to Key Largo from Columbia with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Columbia to Key Largo

How much does it cost to fly round-trip from Columbia, Missouri to Key Largo?

Reviews of airlines servicing Key Largo

Get insights into the airlines that provide service to Key Largo. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Key Largo. Reviews last updated August 28, 2025.
See what other customers who have flown with American Airlines from Columbia to Key Largo have to say. You can also see how each airline compares in terms of entertainment options, comfort, food, crew/service, and boarding process.
American Airlines
7.2
Good
10,000 reviews

Boarding

7.5

Comfort

7.2

Overall

7.2

Crew

8.0

Food

6.5

Entertainment

6.9

Reviews

1 / 20
2.0
Mediocre

Andrew,May 2025

LAX - MIA

2 hour delay. Discovered an engine problem late, we boarded the plane and they asked us to come off. To add insult to injury nothing was given to passengers to make amends. No free drink. No extra food or snacks. No free WiFi. Gimme a break
American Airlines
7.2
Good
10,000 reviews
American Airlines
7.2
Good
10,000 reviews

Boarding

7.5

Comfort

7.2

Overall

7.2

Crew

8.0

Food

6.5

Entertainment

6.9

Reviews

1 / 20
2.0
Mediocre

Andrew,May 2025

LAX - MIA

2 hour delay. Discovered an engine problem late, we boarded the plane and they asked us to come off. To add insult to injury nothing was given to passengers to make amends. No free drink. No extra food or snacks. No free WiFi. Gimme a break

Related info for your journey

Find useful and relevant information for your journey from Columbia to Key Largo. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airport do you fly from for flights from Columbia to Key Largo?

    Columbia Regional (COU), located 11.1 mi from the city center, is the airport you fly out of when you book flights from Columbia to Key Largo. 1 airline have flights from Columbia Regional to Key Largo on a regular basis. Booking flights from Columbia Regional to Key Largo should not be difficult; the airport handles an average of 0 outbound flights to Key Largo per day.

  • How long is the flight from Columbia, Missouri to Key Largo?

    There are many flights that can get you from Columbia, Missouri to Key Largo in 16h 34m. Fly via United Airlines to get the fastest option. There are 1135 mi between Columbia, Missouri and Key Largo.

  • Can I find deals for flights from Columbia to Key Largo that include hotel bookings?

    Yes. In addition to deals on Columbia to Key Largo flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Columbia to Key Largo?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Columbia to Key Largo.

  • Can I find deals for business class flights from Columbia to Key Largo?

    Yes. Cheapflights offers flight deals from Columbia to Key Largo by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Columbia, Missouri to Key Largo?

    Currently, September is the cheapest month in which you can book a flight from Columbia, Missouri to Key Largo (average of $232). Flying from Columbia, Missouri to Key Largo in March is currently the most expensive (average of $289). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

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Top airline flying from Columbia to Key Largo

Discover the top airline that operate flights from Columbia to Key Largo. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated August 28, 2025.
AirlineCheapestAverageFlexibilityOn-time
American AirlinesCheapest$390Average$574FlexibilityNo cancel feeOn-time71%

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