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Key Largo

$433+ Cheap flights from Columbia, MO (COU) to Key Largo, FL

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 10/26. Fares are subject to change and may not be available on all flights or dates of travel.
COU — MIA
Nov 13 — Nov 201
Thu 11/13
Thu 11/20
1 adult, Economy
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Find flight deals from Columbia to Key Largo

Cheapest flights from Columbia to Key Largo
Explore the most affordable flight options available from Columbia to Key Largo. Find the lowest fares from popular airlines and budget airlines, with prices last updated on October 14, 2025.

This American Airlines deal was found by Cheapflights users on 10/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 11/286:32 amCOU - MIA
1 stop13h 18mAmerican Airlines
Sun 12/710:11 pmMIA - COU
1 stop14h 11mAmerican Airlines
Deal found 10/12$521
This American Airlines deal was found by Cheapflights users on 10/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/1011:59 amCOU - MIA
1 stop8h 04mAmerican Airlines
Sat 12/135:05 pmMIA - COU
1 stop5h 56mAmerican Airlines
Deal found 10/13$550
This American Airlines deal was found by Cheapflights users on 10/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/241:49 pmCOU - MIA
1 stop6h 28mAmerican Airlines
Tue 10/285:53 pmMIA - COU
1 stop5h 47mAmerican Airlines
Deal found 10/12$570
This American Airlines deal was found by Cheapflights users on 10/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 12/226:05 pmCOU - MIA
1 stop5h 32mAmerican Airlines
Mon 12/293:59 pmMIA - COU
1 stop7h 00mAmerican Airlines
Deal found 10/13$572
This United Airlines deal was found by Cheapflights users on 10/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/248:00 amCOU - MIA
2 stops26h 16mUnited Airlines
Tue 10/2812:23 pmMIA - COU
1 stop9h 56mUnited Airlines
Deal found 10/12$606
This United Airlines deal was found by Cheapflights users on 10/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 12/223:10 pmCOU - MIA
1 stop18h 20mUnited Airlines
Mon 12/294:43 pmMIA - COU
2 stops22h 52mUnited Airlines
Deal found 10/13$630
This American Airlines deal was found by Cheapflights users on 10/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 11/292:05 pmCOU - MIA
1 stop8h 34mAmerican Airlines
Sun 12/76:20 amMIA - COU
1 stop8h 15mAmerican Airlines
Deal found 10/13$640
This United Airlines deal was found by Cheapflights users on 10/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 11/288:00 amCOU - MIA
1 stop9h 17mUnited Airlines
Sun 12/77:00 amMIA - COU
2 stops32h 26mUnited Airlines
Deal found 10/14$669

Cheap flight deals from Columbia to Key Largo

Keep the following information in mind while searching for Columbia to Key Largo flight deals. Data was last updated October 14, 2025.

Most accurate provider

FlightHub
3 stars

Most trusted provider

FlightHub
3 stars

Round-trip from

$505
(United Airlines)

One-way from

$433
(American Airlines)

Popular in

October

Cheapest in

January

Average price

$1,190
Provider with most accurate pricing for Columbia Regional-Miami flight deals.
Search Deals
Provider most trusted by Cheapflights users for Columbia Regional-Miami flights.
Search Deals
From Columbia Regional to Key Largo
Search Deals
One-way flight from Columbia Regional to Key Largo
Search Deals
Highest demand for flights based on searches. 16% potential increase in price ($142 potential increase over avg. RT price).
Search Deals
Cheapest flight prices on average. 6% potential price decrease ($47 potential savings vs. average RT price).
Search Deals
Average for round-trip flights in October 2025
Search Deals

Cheapflights Fare Finder

 
Customize your flight search to find flights from Columbia to Key Largo that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated October 14, 2025.
Use the filters below to find and compare flights from Columbia to Key Largo that are best for you.

Fly from

Columbia

Fly to

Key Largo

Route

Depart

Return

Price

ColumbiaMiami

COU - MIA

COUMIA

Columbia Regional

Fri 11/28

6:32 am-8:50 pm

1 stop13h 18m

Miami

Sun 12/7

10:11 pm-11:22 am

1 stop14h 11m

$521

ColumbiaMiami

COU - MIA

COUMIA

Columbia Regional

Wed 12/10

12:06 pm-8:53 pm

1 stop7h 47m

Miami

Sat 12/13

11:18 am-5:43 pm

1 stop7h 25m

$550

ColumbiaMiami

COU - MIA

COUMIA

Columbia Regional

Sun 2/22

4:38 pm-12:33 am

2 stops6h 55m

Miami

Sat 2/28

8:20 am-2:38 pm

2 stops7h 18m

$551

ColumbiaMiami

COU - MIA

COUMIA

Columbia Regional

Fri 10/24

1:49 pm-9:17 pm

1 stop6h 28m

Miami

Tue 10/28

5:53 pm-10:40 pm

1 stop5h 47m

$570

ColumbiaMiami

COU - MIA

COUMIA

Columbia Regional

Mon 12/22

6:05 pm-12:37 am

1 stop5h 32m

Miami

Mon 12/29

3:59 pm-9:59 pm

1 stop7h 00m

$572

ColumbiaMiami

COU - MIA

COUMIA

Columbia Regional

Fri 10/24

8:00 am-11:16 am

2 stops26h 16m

Miami

Tue 10/28

12:23 pm-9:19 pm

1 stop9h 56m

$606

ColumbiaMiami

COU - MIA

COUMIA

Columbia Regional

Mon 12/22

3:10 pm-10:30 am

1 stop18h 20m

Miami

Mon 12/29

4:43 pm-2:35 pm

2 stops22h 52m

$630

ColumbiaMiami

COU - MIA

COUMIA

Columbia Regional

Sun 10/26

6:01 am-12:12 pm

1 stop5h 11m

$433

ColumbiaMiami

COU - MIA

COUMIA

Columbia Regional

Sun 10/26

3:02 pm-11:14 am

2 stops19h 12m

$458

Flights are sorted by cheapest round-trip flights first.

Deals found on 10/12

Best time to book a flight from Columbia to Key Largo

Have a flexible travel schedule? Discover the best time to fly to Key Largo from Columbia with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Columbia to Key Largo
No data available for this route at this time. Please check back soon.

Reviews of airlines servicing Key Largo

Get insights into the airlines that provide service to Key Largo. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Key Largo. Reviews last updated October 14, 2025.
See what other customers who have flown with American Airlines from Columbia to Key Largo have to say. You can also see how each airline compares in terms of entertainment options, comfort, food, crew/service, and boarding process.
American Airlines
7.2
Good
11,042 reviews

Comfort

7.2

Crew

8.0

Boarding

7.5

Food

6.4

Entertainment

6.9

Overall

7.2

Reviews

1 / 20
2.0
Mediocre

Andrew,May 2025

LAX - MIA

2 hour delay. Discovered an engine problem late, we boarded the plane and they asked us to come off. To add insult to injury nothing was given to passengers to make amends. No free drink. No extra food or snacks. No free WiFi. Gimme a break
American Airlines
7.2
Good
11,042 reviews
American Airlines
7.2
Good
11,042 reviews

Comfort

7.2

Crew

8.0

Boarding

7.5

Food

6.4

Entertainment

6.9

Overall

7.2

Reviews

1 / 20
2.0
Mediocre

Andrew,May 2025

LAX - MIA

2 hour delay. Discovered an engine problem late, we boarded the plane and they asked us to come off. To add insult to injury nothing was given to passengers to make amends. No free drink. No extra food or snacks. No free WiFi. Gimme a break

Related info for your journey

Find useful and relevant information for your journey from Columbia to Key Largo. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airport do you fly from for flights from Columbia to Key Largo?

    Columbia Regional (COU), located 11.1 mi from the city center, is the airport you fly out of when you book flights from Columbia to Key Largo. 1 airline have flights from Columbia Regional to Key Largo on a regular basis. Booking flights from Columbia Regional to Key Largo should not be difficult; the airport handles an average of 0 outbound flights to Key Largo per day.

  • How long is the flight from Columbia, Missouri to Key Largo?

    There are many flights that can get you from Columbia, Missouri to Key Largo in 13h 18m. Fly via American Airlines to get the fastest option. There are 1135 mi between Columbia, Missouri and Key Largo.

  • Can I find deals for flights from Columbia to Key Largo that include hotel bookings?

    Yes. In addition to deals on Columbia to Key Largo flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Columbia to Key Largo?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Columbia to Key Largo.

  • Can I find deals for business class flights from Columbia to Key Largo?

    Yes. Cheapflights offers flight deals from Columbia to Key Largo by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

See more FAQs

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Top airline flying from Columbia to Key Largo

Discover the top airline that operate flights from Columbia to Key Largo. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated October 14, 2025.
AirlineCheapestAverageFlexibilityOn-time
American AirlinesCheapest$390Average$623FlexibilityNo cancel feeOn-time71%

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