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Key Largo

$274+ Cheap flights from Columbia, MO (COU) to Key Largo, FL

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 3/3. Fares are subject to change and may not be available on all flights or dates of travel.
COU — MIA
Mar 5 — Mar 121
Thu 3/5
Thu 3/12
1 adult, Economy
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Cheap flight deals from Columbia to Key Largo

Cheapest flights from Columbia to Key Largo
Explore the most affordable flight options available from Columbia to Key Largo. Find the lowest fares from popular airlines and budget airlines, with prices last updated on February 3, 2026.

This American Airlines deal was found by Cheapflights users on 2/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 4/1310:13 am
COU
-
MIA
1 stop10h 24m
American Airlines
Fri 4/1710:00 pm
MIA
-
COU
1 stop12h 43m
American Airlines
Deal found 2/1$298
This American Airlines deal was found by Cheapflights users on 2/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 2/226:00 am
COU
-
MIA
1 stop12h 05m
American Airlines
Sat 2/2810:00 pm
MIA
-
COU
1 stop12h 30m
American Airlines
Deal found 2/1$330
This United Airlines deal was found by Cheapflights users on 1/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 2/78:45 am
COU
-
MIA
1 stop10h 06m
United Airlines
Wed 2/119:00 am
MIA
-
COU
2 stops12h 33m
United Airlines
Deal found 1/31$394
This United Airlines deal was found by Cheapflights users on 2/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 7/293:16 pm
COU
-
MIA
1 stop6h 14m
United Airlines
Mon 8/35:25 pm
MIA
-
COU
1 stop8h 05m
United Airlines
Deal found 2/2$399
This United Airlines deal was found by Cheapflights users on 2/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 2/48:10 am
COU
-
MIA
1 stop8h 05m
United Airlines
Wed 2/119:00 am
MIA
-
COU
2 stops12h 33m
United Airlines
Deal found 2/1$404
This United Airlines deal was found by Cheapflights users on 2/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 2/223:10 pm
COU
-
MIA
1 stop6h 19m
United Airlines
Sat 2/286:00 am
MIA
-
COU
2 stops9h 28m
United Airlines
Deal found 2/2$419
This United Airlines deal was found by Cheapflights users on 2/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 4/133:23 pm
COU
-
MIA
1 stop6h 22m
United Airlines
Fri 4/178:55 am
MIA
-
COU
1 stop27h 00m
United Airlines
Deal found 2/2$421
This United Airlines deal was found by Cheapflights users on 1/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 2/108:09 am
COU
-
MIA
1 stop8h 06m
United Airlines
Sat 2/149:00 am
MIA
-
COU
1 stop6h 28m
United Airlines
Deal found 1/31$423
This United Airlines deal was found by Cheapflights users on 2/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 12/126:15 pm
COU
-
MIA
2 stops20h 10m
United Airlines
Sun 12/207:15 am
MIA
-
COU
1 stop8h 14m
United Airlines
Deal found 2/1$441

Find flight deals from Columbia to Key Largo

Keep the following information in mind while searching for Columbia to Key Largo flight deals. Data was last updated February 3, 2026.

Most accurate provider

FlightHub
3 stars

Most trusted provider

FlightHub
3 stars

Round-trip from

$298
(American Airlines)

One-way from

$274
(American Airlines)

Popular in

December

Cheapest in

March

Average price

$624
Provider with most accurate pricing for Columbia Regional-Miami flight deals.
Search Deals
Provider most trusted by Cheapflights users for Columbia Regional-Miami flights.
Search Deals
From Columbia Regional to Key Largo
Search Deals
One-way flight from Columbia Regional to Key Largo
Search Deals
Highest demand for flights based on searches. 8% potential increase in price ($50 potential increase over avg. RT price).
Search Deals
Cheapest flight prices on average. 3% potential price decrease ($18 potential savings vs. average RT price).
Search Deals
Average for round-trip flights in February 2026
Search Deals

Cheapflights Fare Finder

 
Customize your flight search to find flights from Columbia to Key Largo that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated February 3, 2026.
Use the filters below to find and compare flights from Columbia to Key Largo that are best for you.

Fly from

Columbia

Fly to

Key Largo

Route

Depart

Return

Price

ColumbiaMiami

COU - MIA

COUMIA

Columbia Regional

Tue 4/14

6:00 am-8:25 pm

1 stop13h 25m

Miami

Fri 4/17

10:00 pm-9:43 am

1 stop12h 43m

$298

ColumbiaMiami

COU - MIA

COUMIA

Columbia Regional

Sun 2/22

6:00 am-7:05 pm

1 stop12h 05m

Miami

Sat 2/28

10:00 pm-9:30 am

1 stop12h 30m

$330

ColumbiaMiami

COU - MIA

COUMIA

Columbia Regional

Wed 7/29

3:16 pm-10:30 pm

1 stop6h 14m

Miami

Mon 8/3

5:25 pm-12:30 am

1 stop8h 05m

$399

ColumbiaMiami

COU - MIA

COUMIA

Columbia Regional

Sun 2/22

11:15 am-1:13 pm

1 stop24h 58m

Miami

Sat 2/28

6:00 am-2:28 pm

2 stops9h 28m

$442

ColumbiaMiami

COU - MIA

COUMIA

Columbia Regional

Mon 4/20

3:23 pm-10:45 pm

1 stop6h 22m

Miami

Fri 4/24

4:53 pm-10:55 am

2 stops19h 02m

$446

ColumbiaMiami

COU - MIA

COUMIA

Columbia Regional

Tue 4/14

8:00 am-8:58 pm

2 stops11h 58m

Miami

Fri 4/17

4:13 pm-10:55 am

1 stop19h 42m

$446

ColumbiaMiami

COU - MIA

COUMIA

Columbia Regional

Mon 4/13

3:23 pm-10:45 pm

1 stop6h 22m

Miami

Fri 4/17

4:44 pm-10:55 am

2 stops19h 11m

$446

ColumbiaMiami

COU - MIA

COUMIA

Columbia Regional

Sun 5/24

3:16 pm-10:30 pm

1 stop6h 14m

Miami

Sat 5/30

4:17 pm-9:15 pm

1 stop5h 58m

$449

ColumbiaMiami

COU - MIA

COUMIA

Columbia Regional

Mon 2/23

3:10 pm-10:20 pm

1 stop6h 10m

Miami

Fri 3/27

9:00 am-2:06 pm

1 stop6h 06m

$454

ColumbiaMiami

COU - MIA

COUMIA

Columbia Regional

Tue 3/3

10:08 am-9:44 pm

1 stop10h 36m

$274

Flights are sorted by cheapest round-trip flights first.

Deals found on 2/1

Showing 1-10 of 14 results
1
2

Best time to book a flight from Columbia to Key Largo

Have a flexible travel schedule? Discover the best time to fly to Key Largo from Columbia with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Columbia to Key Largo
No data available for this route at this time. Please check back soon.

Reviews of airlines servicing Key Largo

Get insights into the airlines that provide service to Key Largo. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Key Largo. Reviews last updated February 3, 2026.
See what other customers who have flown with American Airlines from Columbia to Key Largo have to say. You can also see how each airline compares in terms of entertainment options, comfort, food, crew/service, and boarding process.
American Airlines
7.2
Good
11,216 reviews

Boarding

7.5

Food

6.4

Entertainment

6.9

Comfort

7.2

Overall

7.2

Crew

8.0

Reviews

1 / 20
2.0
Mediocre

Susie,Jan 2026

CLT - TPA

This flight was delayed 3 or 4 times. We had boarded the plane, sat on plane for a good 30 minutes, then we had to board the aircraft, walk to a different gate, wait and then board another aircraft. We arrived in Tampa 4 hours later than the original booking. I feel there should have been some sort of compensation especially for the advantage members.
American Airlines
7.2
Good
11,216 reviews
American Airlines
7.2
Good
11,216 reviews

Boarding

7.5

Food

6.4

Entertainment

6.9

Comfort

7.2

Overall

7.2

Crew

8.0

Reviews

1 / 20
2.0
Mediocre

Susie,Jan 2026

CLT - TPA

This flight was delayed 3 or 4 times. We had boarded the plane, sat on plane for a good 30 minutes, then we had to board the aircraft, walk to a different gate, wait and then board another aircraft. We arrived in Tampa 4 hours later than the original booking. I feel there should have been some sort of compensation especially for the advantage members.

Related info for your journey

Find useful and relevant information for your journey from Columbia to Key Largo. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airport do you fly from for flights from Columbia to Key Largo?

    Columbia Regional (COU), located 11.1 mi from the city center, is the airport you fly out of when you book flights from Columbia to Key Largo. 1 airline have flights from Columbia Regional to Key Largo on a regular basis. Booking flights from Columbia Regional to Key Largo should not be difficult; the airport handles an average of 0 outbound flights to Key Largo per day.

  • How long is the flight from Columbia, Missouri to Key Largo?

    There are many flights that can get you from Columbia, Missouri to Key Largo in 6h 14m. Fly via American Airlines or United Airlines to get the fastest option. There are 1135 mi between Columbia, Missouri and Key Largo. Both multi-stop and nonstop flights can be found to your destination and back.

  • Can I find deals for flights from Columbia to Key Largo that include hotel bookings?

    Yes. In addition to deals on Columbia to Key Largo flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Columbia to Key Largo?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Columbia to Key Largo.

  • Can I find deals for business class flights from Columbia to Key Largo?

    Yes. Cheapflights offers flight deals from Columbia to Key Largo by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

See more FAQs

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Top airline flying from Columbia to Key Largo

Discover the top airline that operate flights from Columbia to Key Largo. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated February 3, 2026.
AirlineCheapestAverageFlexibilityOn-time
American AirlinesCheapest$415Average$607FlexibilityNo cancel feeOn-time71%

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