$263+ Cheap flights from Columbia, MO (COU) to Key Largo, FL
This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 8/25. Fares are subject to change and may not be available on all flights or dates of travel.
COU — MIA
Jun 4 — Jun 111
Round-trip
1 adult, Economy
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Find cheap flights from Columbia to Key Largo with Cheapflights
1. Tell us where you want to go
Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”2. Select your favorite providers
We find the providers serving your travel needs. Choose up to four travel providers to compare side-by-side for flights, hotels, or car rentals.3. Compare prices and book
Review each provider’s pricing and select the best option for you! Book through your favorite provider’s website for a seamless experience.Cheap flight deals from Columbia to Key Largo
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Best
Last-minute
One-way
Cheapest flights from Columbia to Key LargoExplore the most affordable flight options available from Columbia to Key Largo. Find the lowest fares from popular airlines and budget airlines, with prices last updated on May 5, 2026.
Explore the most affordable flight options available from Columbia to Key Largo. Find the lowest fares from popular airlines and budget airlines, with prices last updated on May 5, 2026.
This American Airlines deal was found by Cheapflights users on 5/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 8/511:48 am
COU
- MIA
1 stop8h 18m
American Airlines
Wed 8/126:25 am
MIA
- COU
1 stop6h 50m
American Airlines
Deal found 5/1![American Airlines logo]()
$328
This American Airlines deal was found by Cheapflights users on 4/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 5/155:21 pm
COU
- MIA
1 stop6h 11m
American Airlines
Sun 5/175:05 am
MIA
- COU
1 stop7h 30m
American Airlines
Deal found 4/30![American Airlines logo]()
$358
This American Airlines deal was found by Cheapflights users on 5/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 7/110:36 am
COU
- MIA
1 stop7h 03m
American Airlines
Mon 7/65:23 pm
MIA
- COU
1 stop6h 23m
American Airlines
Deal found 5/4![American Airlines logo]()
$374
This American Airlines deal was found by Cheapflights users on 5/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 7/245:19 pm
COU
- MIA
1 stop5h 37m
American Airlines
Sat 8/15:23 pm
MIA
- COU
1 stop6h 23m
American Airlines
Deal found 5/3![American Airlines logo]()
$419
This American Airlines deal was found by Cheapflights users on 5/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 7/315:19 pm
COU
- MIA
1 stop5h 37m
American Airlines
Sat 8/86:25 am
MIA
- COU
1 stop7h 05m
American Airlines
Deal found 5/3![American Airlines logo]()
$427
This American Airlines deal was found by Cheapflights users on 5/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 8/35:19 pm
COU
- MIA
1 stop5h 37m
American Airlines
Sun 8/95:00 am
MIA
- COU
1 stop8h 15m
American Airlines
Deal found 5/4![American Airlines logo]()
$428
This United Airlines deal was found by Cheapflights users on 5/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 5/168:00 am
COU
- MIA
1 stop5h 57m
United Airlines
Wed 5/201:20 pm
MIA
- COU
2 stops9h 43m
United Airlines
Deal found 5/1![United Airlines logo]()
$439
This American Airlines deal was found by Cheapflights users on 5/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 7/2911:45 am
COU
- MIA
1 stop7h 50m
American Airlines
Mon 8/35:23 pm
MIA
- COU
1 stop6h 23m
American Airlines
Deal found 5/4![American Airlines logo]()
$472
This American Airlines deal was found by Cheapflights users on 5/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 6/185:19 pm
COU
- MIA
1 stop5h 40m
American Airlines
Thu 6/2512:20 pm
MIA
- COU
1 stop6h 57m
American Airlines
Deal found 5/4![American Airlines logo]()
$476
This United Airlines deal was found by Cheapflights users on 5/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 8/38:00 am
COU
- MIA
1 stop6h 00m
United Airlines
Sun 8/95:40 pm
MIA
- COU
1 stop6h 53m
United Airlines
Deal found 5/3![United Airlines logo]()
$486
This United Airlines deal was found by Cheapflights users on 5/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 8/298:00 am
COU
- MIA
1 stop5h 51m
United Airlines
Wed 9/23:59 pm
MIA
- COU
1 stop6h 50m
United Airlines
Deal found 5/3![United Airlines logo]()
$493
Best flights from Columbia to Key LargoDiscover carefully curated flight deals from Columbia to Key Largo that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated May 5, 2026.
Discover carefully curated flight deals from Columbia to Key Largo that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated May 5, 2026.
This United Airlines deal was found by Cheapflights users on 5/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 8/298:00 am
COU
- MIA
1 stop5h 51m
United Airlines
Wed 9/23:59 pm
MIA
- COU
1 stop6h 50m
United Airlines
Deal found 5/3![United Airlines logo]()
$493
This United Airlines deal was found by Cheapflights users on 5/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 9/38:00 am
COU
- MIA
1 stop5h 51m
United Airlines
Tue 9/812:15 pm
MIA
- COU
1 stop6h 30m
United Airlines
Deal found 5/2![United Airlines logo]()
$511
This United Airlines deal was found by Cheapflights users on 4/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 5/153:10 pm
COU
- MIA
1 stop6h 23m
United Airlines
Tue 5/1910:50 am
MIA
- COU
2 stops10h 59m
United Airlines
Deal found 4/30![United Airlines logo]()
$554
This United Airlines deal was found by Cheapflights users on 5/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 8/28:00 am
COU
- MIA
1 stop6h 00m
United Airlines
Fri 8/78:40 pm
MIA
- COU
2 stops14h 33m
United Airlines
Deal found 5/2![United Airlines logo]()
$608
Last-minute flights from Columbia to Key LargoDiscover last-minute flight deals from Columbia to Key Largo. Data last updated May 5, 2026 and is based on user searches.
Discover last-minute flight deals from Columbia to Key Largo. Data last updated May 5, 2026 and is based on user searches.
This American Airlines deal was found by Cheapflights users on 4/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 5/155:21 pm
COU
- MIA
1 stop6h 11m
American Airlines
Sun 5/175:05 am
MIA
- COU
1 stop7h 30m
American Airlines
Deal found 4/30![American Airlines logo]()
$358
This United Airlines deal was found by Cheapflights users on 4/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 5/153:10 pm
COU
- MIA
1 stop6h 23m
United Airlines
Tue 5/1910:50 am
MIA
- COU
2 stops10h 59m
United Airlines
Deal found 4/30![United Airlines logo]()
$554
This United Airlines deal was found by Cheapflights users on 5/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 5/168:00 am
COU
- MIA
1 stop5h 57m
United Airlines
Wed 5/201:20 pm
MIA
- COU
2 stops9h 43m
United Airlines
Deal found 5/1![United Airlines logo]()
$439
This American Airlines deal was found by Cheapflights users on 5/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 5/2211:44 am
COU
- MIA
1 stop7h 51m
American Airlines
Mon 5/255:24 am
MIA
- COU
1 stop6h 50m
American Airlines
Deal found 5/1![American Airlines logo]()
$616
This American Airlines deal was found by Cheapflights users on 5/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 5/246:32 pm
COU
- MIA
1 stop14h 49m
American Airlines
Fri 5/299:50 pm
MIA
- COU
1 stop13h 10m
American Airlines
Deal found 5/4![American Airlines logo]()
$551
This American Airlines deal was found by Cheapflights users on 5/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 5/315:19 pm
COU
- MIA
1 stop5h 40m
American Airlines
Thu 6/49:01 pm
MIA
- COU
1 stop14h 05m
American Airlines
Deal found 5/4![American Airlines logo]()
$576
This American Airlines deal was found by Cheapflights users on 5/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 5/317:16 am
COU
- MIA
1 stop7h 22m
American Airlines
Sun 6/79:01 pm
MIA
- COU
1 stop14h 05m
American Airlines
Deal found 5/3![American Airlines logo]()
$588
This United Airlines deal was found by Cheapflights users on 5/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 5/318:00 am
COU
- MIA
1 stop6h 04m
United Airlines
Thu 6/48:48 am
MIA
- COU
2 stops12h 51m
United Airlines
Deal found 5/4![United Airlines logo]()
$622
This American Airlines deal was found by Cheapflights users on 5/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 6/15:19 pm
COU
- MIA
1 stop5h 40m
American Airlines
Sun 6/79:01 pm
MIA
- COU
1 stop14h 05m
American Airlines
Deal found 5/2![American Airlines logo]()
$542
This American Airlines deal was found by Cheapflights users on 5/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 6/125:19 pm
COU
- MIA
1 stop5h 40m
American Airlines
Sun 6/213:58 pm
MIA
- COU
1 stop7h 48m
American Airlines
Deal found 5/2![American Airlines logo]()
$518
This American Airlines deal was found by Cheapflights users on 5/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 6/185:19 pm
COU
- MIA
1 stop5h 40m
American Airlines
Thu 6/2512:20 pm
MIA
- COU
1 stop6h 57m
American Airlines
Deal found 5/4![American Airlines logo]()
$476
One-way flights from Columbia to Key LargoSearch for one-way flight options from Columbia to Key Largo. Find affordable one-way fares based on user searches. Data last updated May 5, 2026.
Search for one-way flight options from Columbia to Key Largo. Find affordable one-way fares based on user searches. Data last updated May 5, 2026.
This American Airlines deal was found by Cheapflights users on 5/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 8/256:37 pm
COU
- MIA
1 stop14h 43m
American Airlines
Deal found 5/3![American Airlines logo]()
$263
This United Airlines deal was found by Cheapflights users on 5/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 8/258:00 am
COU
- MIA
2 stops9h 57m
United Airlines
Deal found 5/3![United Airlines logo]()
$281
This American Airlines deal was found by Cheapflights users on 5/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 5/316:00 am
COU
- MIA
1 stop5h 39m
American Airlines
Deal found 5/4![American Airlines logo]()
$308
This American Airlines deal was found by Cheapflights users on 4/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 6/146:47 pm
COU
- MIA
1 stop14h 33m
American Airlines
Deal found 4/30![American Airlines logo]()
$354
This American Airlines deal was found by Cheapflights users on 5/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 5/154:28 pm
COU
- MIA
1 stop5h 44m
American Airlines
Deal found 5/4![American Airlines logo]()
$414
This United Airlines deal was found by Cheapflights users on 5/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 5/313:25 pm
COU
- MIA
2 stops30h 15m
United Airlines
Deal found 5/4![United Airlines logo]()
$523
This United Airlines deal was found by Cheapflights users on 5/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 8/266:30 pm
COU
- MIA
3 stops23h 27m
United Airlines
Deal found 5/3![United Airlines logo]()
$531
This United Airlines deal was found by Cheapflights users on 5/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 5/153:10 pm
COU
- MIA
3 stops26h 08m
United Airlines
Deal found 5/4![United Airlines logo]()
$699
This Qatar Airways deal was found by Cheapflights users on 4/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Qatar Airways is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 6/1410:36 am
COU
- MIA
2 stops53h 04m
Qatar Airways
Deal found 4/30![Qatar Airways logo]()
$2,137
Find flight deals from Columbia to Key Largo
Keep the following information in mind while searching for Columbia to Key Largo flight deals. Data was last updated May 5, 2026.
Most accurate provider | FlightHub 3 stars |
|---|---|
Most trusted provider | FlightHub 3 stars |
Round-trip from | $328 (American Airlines) |
One-way from | $263 (American Airlines) |
Popular in | December |
Cheapest in | February |
Average price | $531 |
Cheapflights Fare Finder
Customize your flight search to find flights from Columbia to Key Largo that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated May 5, 2026.
Use the filters below to find and compare flights from Columbia to Key Largo that are best for you.
Fly from
Fly to
Route
Depart
Return
Cheapest round-trip
ColumbiaMiami
COU - MIA
COUMIA
Columbia Regional
Sat 8/29
8:00 am-2:51 pm
1 stop5h 51m
Miami
Wed 9/2
3:59 pm-9:49 pm
1 stop6h 50m
$493
Quickest round-trip
ColumbiaMiami
COU - MIA
COUMIA
Columbia Regional
Thu 9/3
8:00 am-2:51 pm
1 stop5h 51m
Miami
Tue 9/8
12:15 pm-5:45 pm
1 stop6h 30m
$511
ColumbiaMiami
COU - MIA
COUMIA
Columbia Regional
Fri 5/15
3:10 pm-10:33 pm
1 stop6h 23m
Miami
Tue 5/19
10:50 am-8:49 pm
2 stops10h 59m
$554
ColumbiaMiami
COU - MIA
COUMIA
Columbia Regional
Sun 8/2
8:00 am-3:00 pm
1 stop6h 00m
Miami
Fri 8/7
8:40 pm-10:13 am
2 stops14h 33m
$608
Cheapest one-way
Quickest one-way
ColumbiaMiami
COU - MIA
COUMIA
Columbia Regional
Sun 5/31
6:00 am-12:39 pm
1 stop5h 39m
$308
ColumbiaMiami
COU - MIA
COUMIA
Columbia Regional
Sun 5/31
3:25 pm-10:40 pm
2 stops30h 15m
$523
ColumbiaMiami
COU - MIA
COUMIA
Columbia Regional
Fri 5/15
3:10 pm-6:18 pm
3 stops26h 08m
$699
Sorted by cheapest first
Best time to book a flight from Columbia to Key Largo
Have a flexible travel schedule? Discover the best time to fly to Key Largo from Columbia with our price prediction graph.
COU-MIA
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.
Cheapflights Insights
Everything you need to know about your flight from Columbia to Key Largo
COU-KE9
COU-MIA
How much does it cost to fly round-trip from Columbia, Missouri to Key Largo?
Reviews of airlines servicing Key Largo
Get insights into the airlines that provide service to Key Largo. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Key Largo. Reviews last updated May 5, 2026.
See what other customers who have flown with United Airlines and American Airlines from Columbia to Key Largo have to say. You can also see how each airline compares in terms of entertainment options, comfort, food, crew/service, and boarding process.
Crew
8.1
Boarding
7.7
Overall
7.4
Comfort
7.3
Food
6.6
Entertainment
7.1
Reviews
1 / 20
8.0
ExcellentAnonymous,Apr 2026
DFW - EWR
Crew
8.1
Boarding
7.7
Overall
7.4
Comfort
7.3
Food
6.6
Entertainment
7.1
Reviews
1 / 20
8.0
ExcellentAnonymous,Apr 2026
DFW - EWR
Crew
8.1
Boarding
7.7
Overall
7.4
Comfort
7.3
Food
6.6
Entertainment
7.1
Reviews
1 / 20
8.0
ExcellentAnonymous,Apr 2026
DFW - EWR
Related info for your journey
Find useful and relevant information for your journey from Columbia to Key Largo. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.
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Complete your trip
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Columbia and Key Largo flights
Browse other Columbia and Key Largo flight options. Last updated on May 5, 2026.
Other flights from Columbia
Browse through other flights departing from Columbia. Flights are based on user searches made on Cheapflights and were last updated on May 5, 2026.
Popular flight searches
Check out other popular destinations found by fellow travelers in 2026
Columbia to Key Largo flights
Consider these flights traveling from Columbia to Key Largo.
Top 2 airlines flying from Columbia to Key Largo
Discover the top 2 airlines that operate flights from Columbia to Key Largo. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated May 5, 2026.
| Airline | Cheapest | Average | Flexibility | On-time |
|---|---|---|---|---|
| Cheapest$268 | Average$420 | FlexibilityNo cancel fee | On-time69% | |
| Cheapest$373 | Average$564 | FlexibilityNo cancel fee | On-time71% |