$271+ Cheap flights from Missouri to Jacksonville, NC (OAJ)
This is the cheapest round-trip flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 3/19. Fares are subject to change and may not be available on all flights or dates of travel.
STL — OAJ
Mar 23 — Mar 301
1 adult, Economy
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Find cheap flights from Missouri to Jacksonville with Cheapflights
1. Tell us where you want to go
Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”2. Select your favorite providers
We find the providers serving your travel needs. Choose up to four travel providers to compare side-by-side for flights, hotels, or car rentals.3. Compare prices and book
Review each provider’s pricing and select the best option for you! Book through your favorite provider’s website for a seamless experience.Cheap flight deals from Missouri to Jacksonville
Cheapest
Best
Last-minute
One-way
Cheapest flights from Missouri to JacksonvilleExplore the most affordable flight options available from Missouri to Jacksonville. Find the lowest fares from popular airlines and budget airlines, with prices last updated on February 21, 2026.
Explore the most affordable flight options available from Missouri to Jacksonville. Find the lowest fares from popular airlines and budget airlines, with prices last updated on February 21, 2026.
This Delta deal was found by Cheapflights users on 2/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 3/196:00 am
STL
- OAJ
1 stop6h 40m
Delta
Tue 3/245:43 am
OAJ
- STL
1 stop4h 22m
Delta
Deal found 2/19![Delta logo]()
$271
This Delta deal was found by Cheapflights users on 2/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 3/77:10 am
STL
- OAJ
1 stop6h 37m
Delta
Sat 3/145:43 am
OAJ
- STL
1 stop4h 19m
Delta
Deal found 2/20![Delta logo]()
$275
This American Airlines deal was found by Cheapflights users on 2/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 3/76:06 am
STL
- OAJ
2 stops8h 40m
American Airlines
Sat 3/144:11 pm
OAJ
- STL
1 stop4h 19m
American Airlines
Deal found 2/20![American Airlines logo]()
$280
This Delta deal was found by Cheapflights users on 2/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 4/167:25 am
STL
- OAJ
1 stop5h 15m
Delta
Sun 4/195:40 am
OAJ
- STL
1 stop5h 54m
Delta
Deal found 2/20![Delta logo]()
$353
This Delta deal was found by Cheapflights users on 2/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 3/226:00 am
STL
- OAJ
1 stop4h 12m
Delta
Sun 3/226:51 pm
OAJ
- STL
1 stop6h 07m
Delta
Deal found 2/20![Delta logo]()
$356
This American Airlines deal was found by Cheapflights users on 2/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 3/175:15 pm
MCI
- OAJ
1 stop4h 42m
American Airlines
Tue 3/2411:24 am
OAJ
- MCI
1 stop5h 50m
American Airlines
Deal found 2/17![American Airlines logo]()
$379
This American Airlines deal was found by Cheapflights users on 2/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 3/196:00 am
STL
- OAJ
2 stops8h 46m
American Airlines
Tue 3/2411:24 am
OAJ
- STL
1 stop6h 37m
American Airlines
Deal found 2/20![American Airlines logo]()
$401
This Delta deal was found by Cheapflights users on 2/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 5/207:00 am
MCI
- OAJ
1 stop7h 27m
Delta
Sun 5/245:45 am
OAJ
- MCI
1 stop6h 26m
Delta
Deal found 2/19![Delta logo]()
$403
This Delta deal was found by Cheapflights users on 2/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 3/266:00 am
STL
- OAJ
1 stop4h 12m
Delta
Sun 3/296:51 pm
OAJ
- STL
1 stop6h 07m
Delta
Deal found 2/17![Delta logo]()
$423
This Delta deal was found by Cheapflights users on 2/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 2/258:05 am
MCI
- OAJ
1 stop5h 42m
Delta
Wed 4/15:43 am
OAJ
- MCI
1 stop4h 42m
Delta
Deal found 2/19![Delta logo]()
$430
This American Airlines deal was found by Cheapflights users on 2/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 2/259:13 am
MCI
- OAJ
2 stops8h 33m
American Airlines
Wed 4/17:55 pm
OAJ
- MCI
1 stop5h 04m
American Airlines
Deal found 2/19![American Airlines logo]()
$435
This American Airlines deal was found by Cheapflights users on 2/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 3/296:30 am
MCI
- OAJ
1 stop5h 08m
American Airlines
Sat 4/44:11 pm
OAJ
- MCI
2 stops9h 01m
American Airlines
Deal found 2/20![American Airlines logo]()
$468
Best flights from Missouri to JacksonvilleDiscover carefully curated flight deals from Missouri to Jacksonville that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated February 21, 2026.
Discover carefully curated flight deals from Missouri to Jacksonville that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated February 21, 2026.
This Delta deal was found by Cheapflights users on 2/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 3/196:00 am
STL
- OAJ
1 stop6h 40m
Delta
Tue 3/245:43 am
OAJ
- STL
1 stop4h 22m
Delta
Deal found 2/19![Delta logo]()
$271
This American Airlines deal was found by Cheapflights users on 2/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 3/76:06 am
STL
- OAJ
2 stops8h 40m
American Airlines
Sat 3/145:00 am
OAJ
- STL
1 stop4h 35m
American Airlines
Deal found 2/18![American Airlines logo]()
$280
This Delta deal was found by Cheapflights users on 2/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 3/77:10 am
STL
- OAJ
1 stop6h 37m
Delta
Sat 3/145:43 am
OAJ
- STL
1 stop4h 19m
Delta
Deal found 2/20![Delta logo]()
$275
This American Airlines deal was found by Cheapflights users on 2/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 3/175:15 pm
MCI
- OAJ
1 stop4h 42m
American Airlines
Tue 3/2411:24 am
OAJ
- MCI
1 stop5h 50m
American Airlines
Deal found 2/17![American Airlines logo]()
$379
This Delta deal was found by Cheapflights users on 2/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 3/226:00 am
STL
- OAJ
1 stop4h 12m
Delta
Sun 3/226:51 pm
OAJ
- STL
1 stop6h 07m
Delta
Deal found 2/20![Delta logo]()
$356
This Delta deal was found by Cheapflights users on 2/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 3/295:54 am
MCI
- OAJ
1 stop4h 18m
Delta
Sat 4/411:58 am
OAJ
- MCI
1 stop6h 58m
Delta
Deal found 2/20![Delta logo]()
$379
This Delta deal was found by Cheapflights users on 2/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 5/207:00 am
MCI
- OAJ
1 stop7h 27m
Delta
Sun 5/245:45 am
OAJ
- MCI
1 stop6h 26m
Delta
Deal found 2/19![Delta logo]()
$403
This American Airlines deal was found by Cheapflights users on 2/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 5/2011:05 am
MCI
- OAJ
2 stops11h 52m
American Airlines
Sun 5/245:00 am
OAJ
- MCI
2 stops7h 53m
American Airlines
Deal found 2/19![American Airlines logo]()
$628
This American Airlines deal was found by Cheapflights users on 2/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 3/46:00 am
MCI
- OAJ
2 stops6h 38m
American Airlines
Fri 3/67:55 pm
OAJ
- MCI
1 stop5h 04m
American Airlines
Deal found 2/19![American Airlines logo]()
$649
This American Airlines deal was found by Cheapflights users on 2/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 3/46:00 am
MCI
- OAJ
2 stops6h 38m
American Airlines
Thu 3/51:03 pm
OAJ
- MCI
2 stops10h 57m
American Airlines
Deal found 2/19![American Airlines logo]()
$664
This Delta deal was found by Cheapflights users on 2/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 3/47:00 am
MCI
- OAJ
1 stop6h 47m
Delta
Thu 3/56:40 pm
OAJ
- MCI
1 stop6h 00m
Delta
Deal found 2/19![Delta logo]()
$624
This Delta deal was found by Cheapflights users on 2/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 3/45:35 am
MCI
- OAJ
1 stop4h 32m
Delta
Fri 3/611:48 am
OAJ
- MCI
1 stop6h 18m
Delta
Deal found 2/19![Delta logo]()
$624
Last-minute flights from Missouri to JacksonvilleDiscover last-minute flight deals from Missouri to Jacksonville. Data last updated February 21, 2026 and is based on user searches.
Discover last-minute flight deals from Missouri to Jacksonville. Data last updated February 21, 2026 and is based on user searches.
This American Airlines deal was found by Cheapflights users on 2/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 2/226:57 pm
STL
- OAJ
1 stop3h 58m
American Airlines
Tue 3/1011:24 am
OAJ
- STL
1 stop6h 37m
American Airlines
Deal found 2/21![American Airlines logo]()
$400
This Delta deal was found by Cheapflights users on 2/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 2/258:05 am
MCI
- OAJ
1 stop5h 42m
Delta
Wed 4/15:43 am
OAJ
- MCI
1 stop4h 42m
Delta
Deal found 2/19![Delta logo]()
$430
This American Airlines deal was found by Cheapflights users on 2/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 2/259:13 am
MCI
- OAJ
2 stops8h 33m
American Airlines
Wed 4/17:55 pm
OAJ
- MCI
1 stop5h 04m
American Airlines
Deal found 2/19![American Airlines logo]()
$435
This Delta deal was found by Cheapflights users on 2/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 2/268:05 am
MCI
- OAJ
1 stop4h 29m
Delta
Thu 3/266:51 pm
OAJ
- MCI
1 stop6h 21m
Delta
Deal found 2/19![Delta logo]()
$469
This Delta deal was found by Cheapflights users on 2/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 3/77:10 am
STL
- OAJ
1 stop6h 37m
Delta
Sat 3/145:43 am
OAJ
- STL
1 stop4h 19m
Delta
Deal found 2/20![Delta logo]()
$275
This American Airlines deal was found by Cheapflights users on 2/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 3/76:06 am
STL
- OAJ
2 stops8h 40m
American Airlines
Sat 3/144:11 pm
OAJ
- STL
1 stop4h 19m
American Airlines
Deal found 2/20![American Airlines logo]()
$280
This American Airlines deal was found by Cheapflights users on 2/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 3/175:15 pm
MCI
- OAJ
1 stop4h 42m
American Airlines
Tue 3/2411:24 am
OAJ
- MCI
1 stop5h 50m
American Airlines
Deal found 2/17![American Airlines logo]()
$379
This Delta deal was found by Cheapflights users on 2/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 3/196:00 am
STL
- OAJ
1 stop6h 40m
Delta
Tue 3/245:43 am
OAJ
- STL
1 stop4h 22m
Delta
Deal found 2/19![Delta logo]()
$271
This American Airlines deal was found by Cheapflights users on 2/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 3/196:00 am
STL
- OAJ
2 stops8h 46m
American Airlines
Tue 3/2411:24 am
OAJ
- STL
1 stop6h 37m
American Airlines
Deal found 2/20![American Airlines logo]()
$401
This Delta deal was found by Cheapflights users on 2/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 3/226:00 am
STL
- OAJ
1 stop4h 12m
Delta
Sun 3/226:51 pm
OAJ
- STL
1 stop6h 07m
Delta
Deal found 2/20![Delta logo]()
$356
This Delta deal was found by Cheapflights users on 2/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 3/266:00 am
STL
- OAJ
1 stop4h 12m
Delta
Sun 3/296:51 pm
OAJ
- STL
1 stop6h 07m
Delta
Deal found 2/17![Delta logo]()
$423
This American Airlines deal was found by Cheapflights users on 2/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 3/296:30 am
MCI
- OAJ
1 stop5h 08m
American Airlines
Sat 4/44:11 pm
OAJ
- MCI
2 stops9h 01m
American Airlines
Deal found 2/20![American Airlines logo]()
$468
One-way flights from Missouri to JacksonvilleSearch for one-way flight options from Missouri to Jacksonville. Find affordable one-way fares based on user searches. Data last updated February 21, 2026.
Search for one-way flight options from Missouri to Jacksonville. Find affordable one-way fares based on user searches. Data last updated February 21, 2026.
This American Airlines deal was found by Cheapflights users on 2/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 3/146:57 pm
STL
- OAJ
1 stop3h 58m
American Airlines
Deal found 2/18![American Airlines logo]()
$379
Find flight deals from Missouri to Jacksonville
Keep the following information in mind while searching for Missouri to Jacksonville flight deals. Data was last updated February 21, 2026.
Most accurate provider | FlightHub 3 stars |
|---|---|
Most trusted provider | FlightHub 3 stars |
Round-trip from | $271 (Delta) |
Popular in | December |
Cheapest in | April |
Average price | $407 |
Cheapflights Fare Finder
Customize your flight search to find flights from Missouri to Jacksonville that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated February 21, 2026.
Use the filters below to find and compare flights from Missouri to Jacksonville that are best for you.
Fly from
Missouri
Fly to
Jacksonville
Route
Depart
Return
Price
St. LouisJacksonville
STL - OAJ
STLOAJ
Lambert-St Louis
Thu 3/19
6:00 am-1:40 pm
1 stop6h 40m
Jacksonville Albert J Ellis
Tue 3/24
5:43 am-9:05 am
1 stop4h 22m
$271
St. LouisJacksonville
STL - OAJ
STLOAJ
Lambert-St Louis
Sat 3/7
7:10 am-2:47 pm
1 stop6h 37m
Jacksonville Albert J Ellis
Sat 3/14
5:43 am-9:02 am
1 stop4h 19m
$275
St. LouisJacksonville
STL - OAJ
STLOAJ
Lambert-St Louis
Sat 3/7
6:06 am-3:46 pm
2 stops8h 40m
Jacksonville Albert J Ellis
Sat 3/14
5:00 am-8:35 am
1 stop4h 35m
$280
St. LouisJacksonville
STL - OAJ
STLOAJ
Lambert-St Louis
Sun 3/22
6:00 am-11:12 am
1 stop4h 12m
Jacksonville Albert J Ellis
Sun 3/22
6:51 pm-11:58 pm
1 stop6h 07m
$356
Kansas CityJacksonville
MCI - OAJ
MCIOAJ
Kansas City
Tue 3/17
5:15 pm-10:57 pm
1 stop4h 42m
Jacksonville Albert J Ellis
Tue 3/24
11:24 am-4:14 pm
1 stop5h 50m
$379
Kansas CityJacksonville
MCI - OAJ
MCIOAJ
Kansas City
Sun 3/29
5:54 am-11:12 am
1 stop4h 18m
Jacksonville Albert J Ellis
Sat 4/4
11:58 am-5:56 pm
1 stop6h 58m
$379
Kansas CityJacksonville
MCI - OAJ
MCIOAJ
Kansas City
Wed 5/20
7:00 am-3:27 pm
1 stop7h 27m
Jacksonville Albert J Ellis
Sun 5/24
5:45 am-11:11 am
1 stop6h 26m
$403
Kansas CityJacksonville
MCI - OAJ
MCIOAJ
Kansas City
Wed 3/4
7:00 am-2:47 pm
1 stop6h 47m
Jacksonville Albert J Ellis
Thu 3/5
6:40 pm-11:40 pm
1 stop6h 00m
$624
Kansas CityJacksonville
MCI - OAJ
MCIOAJ
Kansas City
Wed 3/4
5:35 am-11:07 am
1 stop4h 32m
Jacksonville Albert J Ellis
Fri 3/6
11:48 am-5:06 pm
1 stop6h 18m
$624
Kansas CityJacksonville
MCI - OAJ
MCIOAJ
Kansas City
Wed 5/20
11:05 am-11:57 pm
2 stops11h 52m
Jacksonville Albert J Ellis
Sun 5/24
5:00 am-11:53 am
2 stops7h 53m
$628
Showing 1-10 of 13 results
Best time to book a flight from Missouri to Jacksonville
Have a flexible travel schedule? Discover the best time to fly to Jacksonville from Missouri with our price prediction graph.
STL-OAJ
MCI-OAJ
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.
Cheapflights Insights
Everything you need to know about your flight from Missouri to Jacksonville
USMO-OAJ
STL-OAJ
MCI-OAJ
What is the cheapest month to book a flight from Missouri to Jacksonville, North Carolina?
Currently, April is the cheapest month in which you can book a flight from Missouri to Jacksonville, North Carolina (average of $128). Flying from Missouri to Jacksonville, North Carolina in February is currently the most expensive (average of $261). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.
Related info for your journey
Find useful and relevant information for your journey from Missouri to Jacksonville. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.
Browse thousands of different options on Cheapflights for your next trip
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Alternative routes for Missouri to Jacksonville
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Complete your trip
Complete your trip to Jacksonville by adding a car rental and/or hotel reservation to your travel itinerary.
Search flights from Missouri to Jacksonville by cabin class
Find flights from Missouri to Jacksonville, based on your preferred cabin class, be it economy, premium economy, business, or first class.
Other flights to Jacksonville
Explore flights to Jacksonville departing from other origins. Flights are based on user searches made on Cheapflights and were last updated on February 21, 2026.
Missouri and Jacksonville flights
Browse other Missouri and Jacksonville flight options. Last updated on February 21, 2026.
Popular flight searches
Check out other popular destinations found by fellow travelers in 2026
Missouri to Jacksonville flights
Consider these flights traveling from Missouri to Jacksonville.
Top 2 airlines flying from Missouri to Jacksonville
Discover the top 2 airlines that operate flights from Missouri to Jacksonville. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated February 21, 2026.
| Airline | Cheapest | Average | Flexibility | On-time |
|---|---|---|---|---|
| Cheapest$128 | Average$399 | FlexibilityNo cancel fee | On-timeN/A | |
| Cheapest$222 | Average$415 | FlexibilityNo cancel fee | On-time71% |