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$239+ Cheap flights from Des Moines to Harrisburg (DSM - MDT)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 11/25. Fares are subject to change and may not be available on all flights or dates of travel.
DSM — MDT
Nov 28 — Dec 51
Fri 11/28
Fri 12/5
1 adult, Economy
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Cheap flight deals from Des Moines to Harrisburg

Discover tips and strategies to find the most affordable flight options for your journey from Des Moines (DSM) to Harrisburg (MDT). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated October 29, 2025.

Most accurate provider

eDreams
3 stars

Most trusted provider

eDreams
3 stars

Round-trip from

$250
(American Airlines)

One-way from

$239
(Delta)

Popular in

February

Cheapest in

November

Average price

$268
Provider with most accurate pricing for Des Moines-Harrisburg flight deals.
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Provider most trusted by Cheapflights users for Des Moines-Harrisburg flights.
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From Des Moines to Harrisburg
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One-way flight from Des Moines to Harrisburg
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Highest demand for flights based on searches. 12% potential increase in price ($45 potential increase over avg. RT price).
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Cheapest flight prices on average. 2% potential price decrease ($8 potential savings vs. average RT price).
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Average for round-trip flights in October 2025
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Find flight deals from Des Moines to Harrisburg

Cheapest flights from Des Moines to Harrisburg
Explore the most affordable flight options available from Des Moines to Harrisburg. Find the lowest fares from popular airlines and budget airlines, with prices last updated on October 29, 2025.

This United Airlines deal was found by Cheapflights users on 10/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 11/283:15 pmDSM - MDT
1 stop4h 49mUnited Airlines
Fri 12/58:20 amMDT - DSM
1 stop7h 00mUnited Airlines
Deal found 10/29$249
This American Airlines deal was found by Cheapflights users on 10/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 11/232:15 pmDSM - MDT
1 stop5h 43mAmerican Airlines
Tue 12/24:25 pmMDT - DSM
1 stop8h 05mAmerican Airlines
Deal found 10/28$250
This United Airlines deal was found by Cheapflights users on 10/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 11/141:05 pmDSM - MDT
1 stop5h 10mUnited Airlines
Mon 11/176:30 amMDT - DSM
1 stop6h 44mUnited Airlines
Deal found 10/27$254
This American Airlines deal was found by Cheapflights users on 10/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/297:00 amDSM - MDT
1 stop6h 18mAmerican Airlines
Tue 11/44:25 pmMDT - DSM
1 stop8h 05mAmerican Airlines
Deal found 10/28$334
This United Airlines deal was found by Cheapflights users on 10/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/299:01 amDSM - MDT
2 stops11h 03mUnited Airlines
Tue 11/46:30 amMDT - DSM
1 stop5h 00mUnited Airlines
Deal found 10/28$339
This United Airlines deal was found by Cheapflights users on 10/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/133:15 pmDSM - MDT
1 stop4h 49mUnited Airlines
Mon 11/1710:47 amMDT - DSM
1 stop4h 32mUnited Airlines
Deal found 10/29$349
This United Airlines deal was found by Cheapflights users on 10/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/63:15 pmDSM - MDT
1 stop4h 49mUnited Airlines
Mon 11/106:15 amMDT - DSM
2 stops9h 04mUnited Airlines
Deal found 10/27$364
This United Airlines deal was found by Cheapflights users on 10/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 11/2311:26 amDSM - MDT
1 stop4h 27mUnited Airlines
Tue 12/26:15 amMDT - DSM
2 stops12h 09mUnited Airlines
Deal found 10/28$369
This United Airlines deal was found by Cheapflights users on 10/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 11/121:05 pmDSM - MDT
1 stop6h 59mUnited Airlines
Sun 11/166:15 amMDT - DSM
2 stops6h 59mUnited Airlines
Deal found 10/28$379

Cheapflights Fare Finder

 
Customize your flight search to find flights from Des Moines to Harrisburg that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated October 29, 2025.
Use the filters below to find and compare flights from Des Moines to Harrisburg that are best for you.

Fly from

Des Moines

Fly to

Harrisburg

Route

Depart

Return

Price

Des MoinesHarrisburg

DSM - MDT

DSMMDT

Des Moines

Fri 11/28

3:15 pm-9:04 pm

1 stop4h 49m

Harrisburg

Fri 12/5

8:20 am-2:20 pm

1 stop7h 00m

$249

Des MoinesHarrisburg

DSM - MDT

DSMMDT

Des Moines

Fri 11/14

1:05 pm-7:15 pm

1 stop5h 10m

Harrisburg

Mon 11/17

6:30 am-12:14 pm

1 stop6h 44m

$254

Des MoinesHarrisburg

DSM - MDT

DSMMDT

Des Moines

Wed 4/1

5:25 pm-10:47 pm

1 stop4h 22m

Harrisburg

Sat 4/4

6:00 am-10:23 am

1 stop5h 23m

$293

Des MoinesHarrisburg

DSM - MDT

DSMMDT

Des Moines

Thu 1/22

10:21 am-3:55 pm

1 stop4h 34m

Harrisburg

Sun 1/25

6:00 am-9:41 am

1 stop4h 41m

$294

Des MoinesHarrisburg

DSM - MDT

DSMMDT

Des Moines

Thu 1/22

4:25 pm-11:37 pm

1 stop6h 12m

Harrisburg

Sun 1/25

7:30 am-11:12 am

1 stop4h 42m

$299

Des MoinesHarrisburg

DSM - MDT

DSMMDT

Des Moines

Wed 4/1

11:30 am-6:40 pm

1 stop6h 10m

Harrisburg

Sat 4/4

6:00 am-2:11 pm

2 stops9h 11m

$324

Des MoinesHarrisburg

DSM - MDT

DSMMDT

Des Moines

Tue 11/25

6:17 am-11:55 am

1 stop4h 38m

$239

Des MoinesHarrisburg

DSM - MDT

DSMMDT

Des Moines

Wed 11/26

4:03 pm-12:22 am

1 stop7h 19m

$239

Des MoinesHarrisburg

DSM - MDT

DSMMDT

Des Moines

Wed 11/26

5:52 pm-11:04 pm

1 stop4h 12m

$239

Des MoinesHarrisburg

DSM - MDT

DSMMDT

Des Moines

Tue 11/25

8:02 am-6:55 pm

2 stops9h 53m

$279

Flights are sorted by cheapest round-trip flights first.

Deals found on 10/27

Showing 1-10 of 12 results
1
2

Compare providers for flights from Des Moines to Harrisburg

Provider information is updated monthly. Please note that these providers often have deals for this flight, but the availability may vary on a day-by-day basis on Cheapflights.
Use the table below to compare price accuracy, trust ratings, and cancellation policies for each provider offering flight deals from Des Moines to Harrisburg in October.
ProviderPrice AccuracyTrust Score*
FlightHubPrice Accuracy3 starsTrust Score*1 star
ExpediaPrice Accuracy2 starsTrust Score*3 stars
eDreamsPrice Accuracy3 starsTrust Score*3 stars

*The Trust Score is based on feedback from users after their booking experience. It measures overall satisfaction, helping us identify issues like hidden fees, problems during the ticketing process, and the quality of customer service. This score is our best indicator of the provider's quality and reliability.

  • Most accurate provider: When it comes to deals on Des Moines-Harrisburg flights, users find the pricing of eDreams to be most consistent on Cheapflights vs. eDreams Users can find the same prices on Des Moines-Harrisburg flight deals on Cheapflights vs. eDreams >95% of the time. Price accuracy is based on data collected from Des Moines-Harrisburg flight searches over the past month and is updated monthly.
  • Most trusted provider: When it comes to deals on Des Moines-Harrisburg flights, Cheapflights users trust eDreams the most. eDreams has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for Des Moines-Harrisburg flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.

Best time to book a flight from Des Moines to Harrisburg

Have a flexible travel schedule? Discover the best time to fly to Harrisburg from Des Moines with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Des Moines to Harrisburg

What is the cheapest month to book a flight from Des Moines to Harrisburg?

Currently, October is the cheapest month in which you can book a flight from Des Moines to Harrisburg (average of $214). Flying from Des Moines to Harrisburg in July is currently the most expensive (average of $284). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

Reviews of airlines servicing Harrisburg

Get insights into the airlines that provide service to Harrisburg. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Harrisburg. Reviews last updated October 29, 2025.
Get a feel of what it's like to fly with Delta, United Airlines, and American Airlines from Des Moines to Harrisburg by reading reviews from past customers. Users have also rated airlines in terms of entertainment options, comfort, food, crew/service, and boarding process.
Delta
7.9
Good
7,992 reviews

Boarding

8.2

Overall

7.9

Food

7.3

Comfort

7.9

Crew

8.5

Entertainment

7.9

Reviews

1 / 20
8.0
Excellent

Matthew,Oct 2025

GSP - ATL

This is always a full flight since it is the connecting route to primary destinations through Atlanta. That said, the crew handles the full load well. Not much more to say, it is a short flight with no in-flight services due to the length.
Delta
7.9
Good
7,992 reviews
Delta
7.9
Good
7,992 reviews

Boarding

8.2

Overall

7.9

Food

7.3

Comfort

7.9

Crew

8.5

Entertainment

7.9

Reviews

1 / 20
8.0
Excellent

Matthew,Oct 2025

GSP - ATL

This is always a full flight since it is the connecting route to primary destinations through Atlanta. That said, the crew handles the full load well. Not much more to say, it is a short flight with no in-flight services due to the length.
United Airlines
7.4
Good
8,999 reviews
Delta
7.9
Good
7,992 reviews

Boarding

8.2

Overall

7.9

Food

7.3

Comfort

7.9

Crew

8.5

Entertainment

7.9

Reviews

1 / 20
8.0
Excellent

Matthew,Oct 2025

GSP - ATL

This is always a full flight since it is the connecting route to primary destinations through Atlanta. That said, the crew handles the full load well. Not much more to say, it is a short flight with no in-flight services due to the length.
American Airlines
7.2
Good
11,032 reviews
Delta
7.9
Good
7,992 reviews

Boarding

8.2

Overall

7.9

Food

7.3

Comfort

7.9

Crew

8.5

Entertainment

7.9

Reviews

1 / 20
8.0
Excellent

Matthew,Oct 2025

GSP - ATL

This is always a full flight since it is the connecting route to primary destinations through Atlanta. That said, the crew handles the full load well. Not much more to say, it is a short flight with no in-flight services due to the length.

Related info for your journey

Find useful and relevant information for your journey from Des Moines to Harrisburg. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • How long is the flight from Des Moines to Harrisburg?

    Airlines like United Airlines and Delta fly from Des Moines to Harrisburg in about 4h 22m. The time it takes to get you to your destination can typically vary by up to 27m. Airlines will cover a distance of 886 mi. When browsing for deals, the options you’ll see will be for both nonstop flights and flights with stops.

  • What are the cheapest airlines flying from Des Moines to Harrisburg round-trip?

    Flying on United Airlines is currently your cheapest option to Harrisburg, with prices starting at $219. Additional round-trip tickets that might be worth considering are offered by American Airlines and Delta, with the lowest prices starting at $226 and $248, respectively. Users have found that United Airlines is 32% cheaper than the other options available to this destination.

  • Can I find deals for flights from Des Moines to Harrisburg that include hotel bookings?

    Yes. In addition to deals on Des Moines to Harrisburg flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Des Moines to Harrisburg?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Des Moines to Harrisburg.

  • Can I find deals for business class flights from Des Moines to Harrisburg?

    Yes. Cheapflights offers flight deals from Des Moines to Harrisburg by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Des Moines to Harrisburg?

    Currently, October is the cheapest month in which you can book a flight from Des Moines to Harrisburg (average of $214). Flying from Des Moines to Harrisburg in July is currently the most expensive (average of $284). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Traveling to a place near Harrisburg?

Book flights to Harrisburg if you plan to visit one of these locations
Mechanicsburg
Hershey
Carlisle
Camp Hill

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Top 3 airlines flying from Des Moines to Harrisburg

Discover the top 3 airlines that operate flights from Des Moines to Harrisburg. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated October 29, 2025.
AirlineCheapestAverageFlexibilityOn-time
United AirlinesCheapest$219Average$318FlexibilityNo cancel feeOn-time69%
American AirlinesCheapest$226Average$381FlexibilityNo cancel feeOn-time71%
DeltaCheapest$248Average$308FlexibilityNo cancel feeOn-timeN/A

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