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$249+ Cheap flights from Des Moines to Harrisburg (DSM - MDT)

This is the cheapest round-trip flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 8/22. Fares are subject to change and may not be available on all flights or dates of travel.
DSM — MDT
Aug 4 — Aug 111
Mon 8/4
Mon 8/11
1 adult, Economy
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Cheap flight deals from Des Moines to Harrisburg

Discover tips and strategies to find the most affordable flight options for your journey from Des Moines (DSM) to Harrisburg (MDT). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated July 30, 2025.

Round-trip from

$249
(American Airlines)

Popular in

February

Cheapest in

November

Average price

$381
From Des Moines to Harrisburg
Search Deals
Highest demand for flights based on searches. 14% potential increase in price ($55 potential increase over avg. RT price).
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Cheapest flight prices on average. 2% potential price decrease ($8 potential savings vs. average RT price).
Search Deals
Average for round-trip flights in July 2025
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Find flight deals from Des Moines to Harrisburg

Cheapest flights from Des Moines to Harrisburg
Explore the most affordable flight options available from Des Moines to Harrisburg. Find the lowest fares from popular airlines and budget airlines, with prices last updated on July 30, 2025.

This American Airlines deal was found by Cheapflights users on 7/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 8/223:21 pmDSM - MDT
1 stop7h 35mAmerican Airlines
Sun 8/315:00 amMDT - DSM
1 stop4h 58mAmerican Airlines
Deal found 7/28$249
This Delta deal was found by Cheapflights users on 7/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 9/23:50 pmDSM - MDT
1 stop6h 29mDelta
Sat 9/66:10 amMDT - DSM
2 stops11h 19mDelta
Deal found 7/29$254
This United Airlines deal was found by Cheapflights users on 7/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 9/111:10 pmDSM - MDT
1 stop7h 05mUnited Airlines
Sun 9/146:15 amMDT - DSM
2 stops7h 08mUnited Airlines
Deal found 7/29$322
This Mytrip deal was found by Cheapflights users on 7/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 8/41:59 pmDSM - MDT
1 stop5h 02mAllegiant Air
Thu 8/79:19 pmMDT - DSM
2 stops21h 46mAllegiant Air
Deal found 7/29$368
This Mytrip deal was found by Cheapflights users on 7/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 8/41:59 pmDSM - MDT
1 stop5h 02mMultiple Airlines
Thu 8/77:00 pmMDT - DSM
3 stops24h 05mMultiple Airlines
Deal found 7/29$416

Cheapflights Fare Finder

 
Customize your flight search to find flights from Des Moines to Harrisburg that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated July 30, 2025.
Use the filters below to find and compare flights from Des Moines to Harrisburg that are best for you.

Fly from

Des Moines

Fly to

Harrisburg

Route

Depart

Return

Price

Des MoinesHarrisburg

DSM - MDT

DSMMDT

Des Moines

Fri 8/22

3:21 pm-11:56 pm

1 stop7h 35m

Harrisburg

Sun 8/31

5:00 am-8:58 am

1 stop4h 58m

$249

Des MoinesHarrisburg

DSM - MDT

DSMMDT

Des Moines

Tue 9/2

3:50 pm-11:19 pm

1 stop6h 29m

Harrisburg

Sat 9/6

6:10 am-4:29 pm

2 stops11h 19m

$254

Des MoinesHarrisburg

DSM - MDT

DSMMDT

Des Moines

Thu 9/11

1:10 pm-9:15 pm

1 stop7h 05m

Harrisburg

Sun 9/14

6:15 am-12:23 pm

2 stops7h 08m

$322

Des MoinesHarrisburg

DSM - MDT

DSMMDT

Des Moines

Mon 8/4

1:59 pm-8:01 pm

1 stop5h 02m

Harrisburg

Thu 8/7

9:19 pm-6:05 pm

2 stops21h 46m

$368

Des MoinesHarrisburg

DSM - MDT

DSMMDT

Des Moines

Mon 8/4

1:59 pm-8:01 pm

1 stop5h 02m

Harrisburg

Thu 8/7

7:00 pm-6:05 pm

3 stops24h 05m

$416

Flights are sorted by cheapest round-trip flights first.

Deals found on 7/28

Best time to book a flight from Des Moines to Harrisburg

Have a flexible travel schedule? Discover the best time to fly to Harrisburg from Des Moines with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Des Moines to Harrisburg

What is the cheapest month to book a flight from Des Moines to Harrisburg?

Currently, January is the cheapest month in which you can book a flight from Des Moines to Harrisburg (average of $355). Flying from Des Moines to Harrisburg in November is currently the most expensive (average of $408). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

Reviews of airlines servicing Harrisburg

Get insights into the airlines that provide service to Harrisburg. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Harrisburg. Reviews last updated July 30, 2025.
Get a feel of what it's like to fly with Delta, United Airlines, and American Airlines from Des Moines to Harrisburg by reading reviews from past customers. Users have also rated airlines in terms of entertainment options, comfort, food, crew/service, and boarding process.
Delta
8.0
Very good
7,980 reviews

Food

7.3

Comfort

7.9

Entertainment

7.9

Boarding

8.2

Crew

8.5

Overall

8.0

Reviews

1 / 20
10.0
Excellent

Kim,May 2025

PIH - SLC

This trip was fine even with delay I had plenty of time to get connection flight!
Delta
8.0
Very good
7,980 reviews
Delta
8.0
Very good
7,980 reviews

Food

7.3

Comfort

7.9

Entertainment

7.9

Boarding

8.2

Crew

8.5

Overall

8.0

Reviews

1 / 20
10.0
Excellent

Kim,May 2025

PIH - SLC

This trip was fine even with delay I had plenty of time to get connection flight!
United Airlines
7.4
Good
8,896 reviews
Delta
8.0
Very good
7,980 reviews

Food

7.3

Comfort

7.9

Entertainment

7.9

Boarding

8.2

Crew

8.5

Overall

8.0

Reviews

1 / 20
10.0
Excellent

Kim,May 2025

PIH - SLC

This trip was fine even with delay I had plenty of time to get connection flight!
American Airlines
7.2
Good
10,000 reviews
Delta
8.0
Very good
7,980 reviews

Food

7.3

Comfort

7.9

Entertainment

7.9

Boarding

8.2

Crew

8.5

Overall

8.0

Reviews

1 / 20
10.0
Excellent

Kim,May 2025

PIH - SLC

This trip was fine even with delay I had plenty of time to get connection flight!
Allegiant Air
7.2
Good
703 reviews
Delta
8.0
Very good
7,980 reviews

Food

7.3

Comfort

7.9

Entertainment

7.9

Boarding

8.2

Crew

8.5

Overall

8.0

Reviews

1 / 20
10.0
Excellent

Kim,May 2025

PIH - SLC

This trip was fine even with delay I had plenty of time to get connection flight!

Related info for your journey

Find useful and relevant information for your journey from Des Moines to Harrisburg. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What are the cheapest airlines flying from Des Moines to Harrisburg round-trip?

    Flying on American Airlines is currently your cheapest option to Harrisburg, with prices starting at $249. Additional round-trip tickets that might be worth considering are offered by Delta and United Airlines, with the lowest prices starting at $254 and $322, respectively. Users have found that American Airlines is 22% cheaper than the other options available to this destination.

  • Can I find deals for flights from Des Moines to Harrisburg that include hotel bookings?

    Yes. In addition to deals on Des Moines to Harrisburg flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Des Moines to Harrisburg?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Des Moines to Harrisburg.

  • Can I find deals for business class flights from Des Moines to Harrisburg?

    Yes. Cheapflights offers flight deals from Des Moines to Harrisburg by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Des Moines to Harrisburg?

    Currently, January is the cheapest month in which you can book a flight from Des Moines to Harrisburg (average of $355). Flying from Des Moines to Harrisburg in November is currently the most expensive (average of $408). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Traveling to a place near Harrisburg?

Book flights to Harrisburg if you plan to visit one of these locations
Carlisle
Hershey
Mechanicsburg
Camp Hill

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Top 3 airlines flying from Des Moines to Harrisburg

Discover the top 3 airlines that operate flights from Des Moines to Harrisburg. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated July 30, 2025.
AirlineCheapestAverageFlexibilityOn-time
DeltaCheapest$248Average$278FlexibilityNo cancel feeOn-timeN/A
American AirlinesCheapest$274Average$381FlexibilityNo cancel feeOn-time71%
United AirlinesCheapest$318Average$339FlexibilityNo cancel feeOn-time69%

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