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$160+ Cheap flights from Des Moines to Harrisburg (DSM - MDT)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 10/13. Fares are subject to change and may not be available on all flights or dates of travel.
DSM — MDT
oct. 11 — oct. 181
sáb. 10/11
sáb. 10/18
1 adult, Economy
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Cheap flight deals from Des Moines to Harrisburg

Discover tips and strategies to find the most affordable flight options for your journey from Des Moines (DSM) to Harrisburg (MDT). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated septiembre 11, 2025.

Round-trip from

$249
(Delta)

One-way from

$160
(Kiwi.com)

Popular in

February

Cheapest in

November

Average price

$278
From Des Moines to Harrisburg
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One-way flight from Des Moines to Harrisburg
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Highest demand for flights based on searches. 14% potential increase in price ($52 potential increase over avg. RT price).
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Cheapest flight prices on average. 2% potential price decrease ($9 potential savings vs. average RT price).
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Average for round-trip flights in September 2025
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Find flight deals from Des Moines to Harrisburg

Cheapest flights from Des Moines to Harrisburg
Explore the most affordable flight options available from Des Moines to Harrisburg. Find the lowest fares from popular airlines and budget airlines, with prices last updated on septiembre 11, 2025.

This Delta deal was found by Cheapflights users on 9/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
mié. 10/82:13 pmDSM - MDT
1 stop7h 55mDelta
sáb. 10/116:00 amMDT - DSM
1 stop5h 05mDelta
Deal found 9/11$249
This United Airlines deal was found by Cheapflights users on 9/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
vie. 9/1211:35 amDSM - MDT
1 stop7h 17mUnited Airlines
dom. 9/146:45 amMDT - DSM
1 stop6h 38mUnited Airlines
Deal found 9/10$339
This Kiwi.com deal was found by Cheapflights users on 9/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
mié. 10/83:17 pmDSM - MDT
1 stop22h 30mAllegiant Air
vie. 10/109:28 amMDT - DSM
1 stop24h 01mAllegiant Air
Deal found 9/11$365
This United Airlines deal was found by Cheapflights users on 9/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
vie. 10/1011:31 amDSM - MDT
1 stop4h 21mUnited Airlines
dom. 10/126:15 amMDT - DSM
2 stops9h 08mUnited Airlines
Deal found 9/10$369
This American Airlines deal was found by Cheapflights users on 9/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
lun. 10/66:07 pmDSM - MDT
1 stop4h 41mAmerican Airlines
lun. 10/138:11 pmMDT - DSM
1 stop4h 12mAmerican Airlines
Deal found 9/10$377
This Delta deal was found by Cheapflights users on 9/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
lun. 12/225:47 pmDSM - MDT
1 stop4h 04mDelta
vie. 12/266:10 amMDT - DSM
1 stop4h 38mDelta
Deal found 9/9$379
This United Airlines deal was found by Cheapflights users on 9/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
mié. 10/86:36 pmDSM - MDT
2 stops13h 53mUnited Airlines
sáb. 10/118:15 amMDT - DSM
1 stop7h 08mUnited Airlines
Deal found 9/11$413
This Delta deal was found by Cheapflights users on 9/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
lun. 11/105:52 pmDSM - MDT
1 stop4h 12mDelta
vie. 11/145:00 pmMDT - DSM
1 stop4h 47mDelta
Deal found 9/11$467
This United Airlines deal was found by Cheapflights users on 9/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
mié. 10/88:00 amDSM - MDT
2 stops9h 59mUnited Airlines
vie. 10/106:30 amMDT - DSM
1 stop6h 49mUnited Airlines
Deal found 9/11$482
This United Airlines deal was found by Cheapflights users on 9/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
vie. 9/263:25 pmDSM - MDT
1 stop5h 00mUnited Airlines
mar. 9/305:48 pmMDT - DSM
1 stop5h 02mUnited Airlines
Deal found 9/11$526

Cheapflights Fare Finder

 
Customize your flight search to find flights from Des Moines to Harrisburg that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated septiembre 11, 2025.
Use the filters below to find and compare flights from Des Moines to Harrisburg that are best for you.

Fly from

Des Moines

Fly to

Harrisburg

Route

Depart

Return

Price

Des MoinesHarrisburg

DSM - MDT

DSMMDT

Des Moines

jue. 1/22

6:15 pm-11:47 pm

1 stop4h 32m

Harrisburg

dom. 1/25

7:30 am-11:12 am

1 stop4h 42m

$294

Des MoinesHarrisburg

DSM - MDT

DSMMDT

Des Moines

mié. 1/21

7:09 am-12:52 pm

1 stop4h 43m

Harrisburg

dom. 1/25

7:30 am-11:12 am

1 stop4h 42m

$294

Des MoinesHarrisburg

DSM - MDT

DSMMDT

Des Moines

jue. 1/22

3:35 pm-9:15 pm

1 stop4h 40m

Harrisburg

dom. 1/25

6:15 am-2:33 pm

2 stops9h 18m

$324

Des MoinesHarrisburg

DSM - MDT

DSMMDT

Des Moines

mié. 1/21

3:35 pm-9:15 pm

1 stop4h 40m

Harrisburg

dom. 1/25

6:15 am-2:33 pm

2 stops9h 18m

$324

Des MoinesHarrisburg

DSM - MDT

DSMMDT

Des Moines

vie. 10/10

6:07 pm-11:48 pm

1 stop4h 41m

Harrisburg

dom. 10/12

6:36 am-10:51 am

1 stop5h 15m

$339

Des MoinesHarrisburg

DSM - MDT

DSMMDT

Des Moines

vie. 10/10

2:13 pm-11:08 pm

1 stop7h 55m

Harrisburg

dom. 10/12

6:00 am-10:05 am

1 stop5h 05m

$344

Des MoinesHarrisburg

DSM - MDT

DSMMDT

Des Moines

mié. 10/8

3:17 pm-2:47 pm

1 stop22h 30m

Harrisburg

vie. 10/10

9:28 am-8:29 am

1 stop24h 01m

$365

Des MoinesHarrisburg

DSM - MDT

DSMMDT

Des Moines

lun. 10/6

6:07 pm-11:48 pm

1 stop4h 41m

Harrisburg

lun. 10/13

8:11 pm-11:23 pm

1 stop4h 12m

$377

Des MoinesHarrisburg

DSM - MDT

DSMMDT

Des Moines

lun. 10/13

2:39 pm-8:18 am

2 stops40h 39m

$160

Des MoinesHarrisburg

DSM - MDT

DSMMDT

Des Moines

jue. 10/9

10:51 am-7:35 pm

2 stops31h 44m

$222

Flights are sorted by cheapest round-trip flights first.

Deals found on 9/10

Showing 1-10 of 15 results
1
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Best time to book a flight from Des Moines to Harrisburg

Have a flexible travel schedule? Discover the best time to fly to Harrisburg from Des Moines with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Des Moines to Harrisburg

What is the cheapest month to book a flight from Des Moines to Harrisburg?

Currently, August is the cheapest month in which you can book a flight from Des Moines to Harrisburg (average of $347). Flying from Des Moines to Harrisburg in November is currently the most expensive (average of $408). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

Reviews of airlines servicing Harrisburg

Get insights into the airlines that provide service to Harrisburg. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Harrisburg. Reviews last updated septiembre 11, 2025.
Get a feel of what it's like to fly with Delta, United Airlines, and American Airlines from Des Moines to Harrisburg by reading reviews from past customers. Users have also rated airlines in terms of entertainment options, comfort, food, crew/service, and boarding process.
Delta
8.0
Very good
7,960 reviews

Comfort

7.9

Entertainment

7.9

Overall

8.0

Food

7.3

Crew

8.5

Boarding

8.2

Reviews

1 / 20
10.0
Excellent

Kim,May 2025

PIH - SLC

This trip was fine even with delay I had plenty of time to get connection flight!
Delta
8.0
Very good
7,960 reviews
Delta
8.0
Very good
7,960 reviews

Comfort

7.9

Entertainment

7.9

Overall

8.0

Food

7.3

Crew

8.5

Boarding

8.2

Reviews

1 / 20
10.0
Excellent

Kim,May 2025

PIH - SLC

This trip was fine even with delay I had plenty of time to get connection flight!
United Airlines
7.4
Good
8,937 reviews
Delta
8.0
Very good
7,960 reviews

Comfort

7.9

Entertainment

7.9

Overall

8.0

Food

7.3

Crew

8.5

Boarding

8.2

Reviews

1 / 20
10.0
Excellent

Kim,May 2025

PIH - SLC

This trip was fine even with delay I had plenty of time to get connection flight!
American Airlines
7.2
Good
10,000 reviews
Delta
8.0
Very good
7,960 reviews

Comfort

7.9

Entertainment

7.9

Overall

8.0

Food

7.3

Crew

8.5

Boarding

8.2

Reviews

1 / 20
10.0
Excellent

Kim,May 2025

PIH - SLC

This trip was fine even with delay I had plenty of time to get connection flight!

Related info for your journey

Find useful and relevant information for your journey from Des Moines to Harrisburg. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • How long is the flight from Des Moines to Harrisburg?

    Airlines like American Airlines and United Airlines fly from Des Moines to Harrisburg in about 4h 32m. The time it takes to get you to your destination can typically vary by up to 08m. Airlines will cover a distance of 886 mi. When browsing for deals, the options you’ll see will be for both nonstop flights and flights with stops.

  • What are the cheapest airlines flying from Des Moines to Harrisburg round-trip?

    Flying on Delta is currently your cheapest option to Harrisburg, with prices starting at $248. Additional round-trip tickets that might be worth considering are offered by United Airlines and American Airlines, with the lowest prices starting at $258 and $268, respectively. Users have found that Delta is 22% cheaper than the other options available to this destination.

  • Can I find deals for flights from Des Moines to Harrisburg that include hotel bookings?

    Yes. In addition to deals on Des Moines to Harrisburg flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Des Moines to Harrisburg?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Des Moines to Harrisburg.

  • Can I find deals for business class flights from Des Moines to Harrisburg?

    Yes. Cheapflights offers flight deals from Des Moines to Harrisburg by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Des Moines to Harrisburg?

    Currently, August is the cheapest month in which you can book a flight from Des Moines to Harrisburg (average of $347). Flying from Des Moines to Harrisburg in November is currently the most expensive (average of $408). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Traveling to a place near Harrisburg?

Book flights to Harrisburg if you plan to visit one of these locations
Carlisle
Mechanicsburg
Hershey
Camp Hill

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Top 3 airlines flying from Des Moines to Harrisburg

Discover the top 3 airlines that operate flights from Des Moines to Harrisburg. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated septiembre 11, 2025.
AirlineCheapestAverageFlexibilityOn-time
DeltaCheapest$248Average$318FlexibilityNo cancel feeOn-timeN/A
United AirlinesCheapest$258Average$435FlexibilityNo cancel feeOn-time69%
American AirlinesCheapest$268Average$369FlexibilityNo cancel feeOn-time71%

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