What are the cheapest airlines flying from Des Moines to Guadalajara round-trip?

According to our current data, American Airlines ($518), and United Airlines ($521) offers the cheapest pricing from Des Moines to Guadalajara. Users have found that American Airlines is 18% cheaper than the other options available to this destination.

In terms of precipitation, rainfall in Guadalajara ranges from 0.0 - 9.4 inches per month. July is typically the wettest month, when rainfall can reach 9.4 in. February is typically the driest time to visit Guadalajara when rainfall is around 0.0 in.

If weather is an important factor for your trip to Guadalajara, use this chart to help with planning. For those seeking warmer temperatures, June is the ideal time of year to visit, when temperatures reach an average of 73.4 F. Travelers looking to avoid the cold should look outside of January, when temperatures are typically at their lowest (around 59.0 F).

What is the cheapest time of day to fly from DSM to GDL?

Regardless of the time of day you decide to fly, the ticket price will remain around the same. Book flights from Des Moines to Guadalajara as you normally would.

Most accurate provider : When it comes to deals on Des Moines-Guadalajara flights, users find the pricing of eDreams to be most consistent on Cheapflights vs. eDreams Users can find the same prices on Des Moines-Guadalajara flight deals on Cheapflights vs. eDreams >95% of the time. Price accuracy is based on data collected from Des Moines-Guadalajara flight searches over the past month and is updated monthly.

Most trusted provider : When it comes to deals on Des Moines-Guadalajara flights, Cheapflights users trust eDreams the most. eDreams has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for Des Moines-Guadalajara flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.

Can I find deals for flights from Des Moines to Guadalajara that include hotel bookings?

Yes. In addition to deals on Des Moines to Guadalajara flights, Cheapflights offers vacation packages that include both flights and hotel.

How can I find direct flights from Des Moines to Guadalajara?

After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Des Moines to Guadalajara.

Can I find deals for business class flights from Des Moines to Guadalajara?

Yes. Cheapflights offers flight deals from Des Moines to Guadalajara by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

$137+ Flights from Des Moines to Guadalajara

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1. Tell us where you want to go

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Cheap flight deals from Des Moines to Guadalajara

Most accurate provider	eDreams 3 stars
Most trusted provider	eDreams 3 stars
Round-trip from	$412 (Mytrip)
One-way from	$137 (Mytrip)
Popular in	December
Cheapest in	April
Average price	$633

Provider with most accurate pricing for Des Moines-Guadalajara Miguel Hidal flight deals.

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Provider most trusted by Cheapflights users for Des Moines-Guadalajara Miguel Hidal flights.

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From Des Moines to Guadalajara Miguel Hidal

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One-way flight from Des Moines to Guadalajara Miguel Hidal

Search Deals

Highest demand for flights based on searches. 7% potential increase in price ($51 potential increase over avg. RT price).

Search Deals

Cheapest flight prices on average. 2% potential price decrease ($18 potential savings vs. average RT price).

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Average for round-trip flights in November 2025

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Find flight deals from Des Moines to Guadalajara

Cheapest flights from Des Moines to Guadalajara
Explore the most affordable flight options available from Des Moines to Guadalajara. Find the lowest fares from popular airlines and budget airlines, with prices last updated on November 14, 2025.

Wed 11/262:00 pmDSM - GDL

2 stops27h 05mMultiple Airlines

Wed 12/312:29 pmGDL - DSM

1 stop27h 02mMultiple Airlines

Deal found 11/12

$422

Wed 11/262:00 pmDSM - GDL

2 stops27h 05mMultiple Airlines

Thu 12/412:29 pmGDL - DSM

1 stop30h 09mMultiple Airlines

Deal found 11/12

$430

Mon 11/243:48 pmDSM - GDL

1 stop28h 47mMultiple Airlines

Thu 12/410:25 amGDL - DSM

2 stops32h 38mMultiple Airlines

Deal found 11/12

$438

Mon 11/243:48 pmDSM - GDL

1 stop28h 47mMultiple Airlines

Wed 12/312:29 pmGDL - DSM

1 stop27h 02mMultiple Airlines

Deal found 11/12

$446

Tue 11/257:46 pmDSM - GDL

2 stops25h 34mMultiple Airlines

Wed 12/312:29 pmGDL - DSM

1 stop27h 02mMultiple Airlines

Deal found 11/12

$450

Tue 11/257:46 pmDSM - GDL

1 stop20h 39mMultiple Airlines

Thu 12/410:25 amGDL - DSM

2 stops32h 38mMultiple Airlines

Deal found 11/12

$456

Best flights from Des Moines to Guadalajara
Discover carefully curated flight deals from Des Moines to Guadalajara that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated November 14, 2025.

Sun 12/148:30 amDSM - GDL

1 stop12h 05mMultiple Airlines

Mon 12/159:35 amGDL - DSM

1 stop9h 03mMultiple Airlines

Deal found 11/13

$459

Fri 1/164:00 pmDSM - GDL

1 stop7h 59mAmerican Airlines

Mon 1/196:00 amGDL - DSM

1 stop9h 15mAmerican Airlines

Deal found 11/13

$578

Sat 12/138:15 amDSM - GDL

1 stop12h 35mUnited Airlines

Tue 12/168:00 amGDL - DSM

1 stop6h 12mUnited Airlines

Deal found 11/13

$638

Tue 12/95:34 amDSM - GDL

1 stop7h 05mDelta

Wed 12/102:06 pmGDL - DSM

1 stop8h 28mDelta

Deal found 11/13

$656

Mon 11/243:48 pmDSM - GDL

1 stop28h 47mMultiple Airlines

Fri 11/288:02 amGDL - DSM

1 stop10h 59mMultiple Airlines

Deal found 11/12

$480

Fri 12/57:58 pmDSM - GDL

1 stop24h 42mMultiple Airlines

Fri 12/198:20 pmGDL - DSM

2 stops23h 24mMultiple Airlines

Deal found 11/12

$483

Tue 12/23:21 pmDSM - GDL

1 stop8h 37mAmerican Airlines

Mon 12/155:44 amGDL - DSM

1 stop9h 07mAmerican Airlines

Deal found 11/13

$631

Tue 12/28:00 amDSM - GDL

2 stops12h 50mUnited Airlines

Mon 12/158:00 amGDL - DSM

1 stop6h 12mUnited Airlines

Deal found 11/13

$641

Mon 12/157:28 pmDSM - GDL

1 stop25h 07mMultiple Airlines

Mon 12/296:10 amGDL - DSM

2 stops13h 34mMultiple Airlines

Deal found 11/13

$561

Fri 1/98:30 amDSM - GDL

1 stop12h 05mMultiple Airlines

Mon 1/198:02 amGDL - DSM

1 stop11h 21mMultiple Airlines

Deal found 11/13

$602

Last-minute flights from Des Moines to Guadalajara
Discover last-minute flight deals from Des Moines to Guadalajara. Data last updated November 14, 2025 and is based on user searches.

Mon 11/243:48 pmDSM - GDL

1 stop28h 47mMultiple Airlines

Thu 12/410:25 amGDL - DSM

2 stops32h 38mMultiple Airlines

Deal found 11/12

$438

Mon 11/243:48 pmDSM - GDL

1 stop28h 47mMultiple Airlines

Wed 12/312:29 pmGDL - DSM

1 stop27h 02mMultiple Airlines

Deal found 11/12

$446

Tue 11/257:46 pmDSM - GDL

2 stops25h 34mMultiple Airlines

Wed 12/312:29 pmGDL - DSM

1 stop27h 02mMultiple Airlines

Deal found 11/12

$450

Tue 11/257:46 pmDSM - GDL

1 stop20h 39mMultiple Airlines

Thu 12/410:25 amGDL - DSM

2 stops32h 38mMultiple Airlines

Deal found 11/12

$456

Wed 11/262:00 pmDSM - GDL

2 stops27h 05mMultiple Airlines

Wed 12/312:29 pmGDL - DSM

1 stop27h 02mMultiple Airlines

Deal found 11/12

$422

Wed 11/262:00 pmDSM - GDL

2 stops27h 05mMultiple Airlines

Thu 12/412:29 pmGDL - DSM

1 stop30h 09mMultiple Airlines

Deal found 11/12

$430

Mon 12/112:16 pmDSM - GDL

1 stop8h 19mMultiple Airlines

Mon 12/159:35 amGDL - DSM

1 stop9h 03mMultiple Airlines

Deal found 11/14

$412

One-way flights from Des Moines to Guadalajara
Search for one-way flight options from Des Moines to Guadalajara. Find affordable one-way fares based on user searches. Data last updated November 14, 2025.

Mon 1/128:30 amDSM - GDL

1 stop12h 05mMultiple Airlines

Deal found 11/12

$137

Fri 12/127:58 pmDSM - GDL

2 stops17h 59mMultiple Airlines

Deal found 11/12

$198

Sun 11/308:19 pmDSM - GDL

2 stops40h 01mMultiple Airlines

Deal found 11/12

$293

Wed 12/102:53 pmDSM - GDL

1 stop5h 57mUnited Airlines

Deal found 11/12

$348

Wed 12/108:00 amDSM - GDL

3 stops56h 28mMultiple Airlines

Deal found 11/12

$373

Cheapflights Fare Finder

Use the filters below to find and compare flights from Des Moines to Guadalajara that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Des MoinesGuadalajara

DSM - GDL

DSMGDL

Des Moines

Sun 12/14

8:30 am-8:35 pm

1 stop12h 05m

Guadalajara Miguel Hidal

Mon 12/15

9:35 am-6:38 pm

1 stop9h 03m

$459

Des MoinesGuadalajara

DSM - GDL

DSMGDL

Des Moines

Mon 11/24

3:48 pm-8:35 pm

1 stop28h 47m

Guadalajara Miguel Hidal

Fri 11/28

8:02 am-7:01 pm

1 stop10h 59m

$480

Des MoinesGuadalajara

DSM - GDL

DSMGDL

Des Moines

Fri 12/5

7:58 pm-8:40 pm

1 stop24h 42m

Guadalajara Miguel Hidal

Fri 12/19

8:20 pm-7:44 pm

2 stops23h 24m

$483

Des MoinesGuadalajara

DSM - GDL

DSMGDL

Des Moines

Mon 12/15

7:28 pm-8:35 pm

1 stop25h 07m

Guadalajara Miguel Hidal

Mon 12/29

6:10 am-7:44 pm

2 stops13h 34m

$561

Des MoinesGuadalajara

DSM - GDL

DSMGDL

Des Moines

Fri 1/16

4:00 pm-11:59 pm

1 stop7h 59m

Guadalajara Miguel Hidal

Mon 1/19

6:00 am-3:15 pm

1 stop9h 15m

$578

Des MoinesGuadalajara

DSM - GDL

DSMGDL

Des Moines

Fri 1/9

8:30 am-8:35 pm

1 stop12h 05m

Guadalajara Miguel Hidal

Mon 1/19

8:02 am-7:23 pm

1 stop11h 21m

$602

Des MoinesGuadalajara

DSM - GDL

DSMGDL

Des Moines

Tue 12/2

3:21 pm-11:58 pm

1 stop8h 37m

Guadalajara Miguel Hidal

Mon 12/15

5:44 am-2:51 pm

1 stop9h 07m

$631

Des MoinesGuadalajara

DSM - GDL

DSMGDL

Des Moines

Sat 12/13

8:15 am-8:50 pm

1 stop12h 35m

Guadalajara Miguel Hidal

Tue 12/16

8:00 am-2:12 pm

1 stop6h 12m

$638

Des MoinesGuadalajara

DSM - GDL

DSMGDL

Des Moines

Tue 12/2

8:00 am-8:50 pm

2 stops12h 50m

Guadalajara Miguel Hidal

Mon 12/15

8:00 am-2:12 pm

1 stop6h 12m

$641

Des MoinesGuadalajara

DSM - GDL

DSMGDL

Des Moines

Tue 12/9

5:34 am-12:39 pm

1 stop7h 05m

Guadalajara Miguel Hidal

Wed 12/10

2:06 pm-10:34 pm

1 stop8h 28m

$656

Flights are sorted by cheapest round-trip flights first.

Deals found on 11/12

Showing 1-10 of 15 results

Compare providers for flights from Des Moines to Guadalajara

Use the table below to compare price accuracy, trust ratings, and cancellation policies for each provider offering flight deals from Des Moines to Guadalajara in November.

Provider	Price Accuracy	Trust Score*
Expedia	Price Accuracy2 stars	Trust Score*3 stars
FlightHub	Price Accuracy3 stars	Trust Score*1 star
eDreams	Price Accuracy3 stars	Trust Score*3 stars
AranGrant	Price Accuracy2 stars	Trust Score*3 stars

*The Trust Score is based on feedback from users after their booking experience. It measures overall satisfaction, helping us identify issues like hidden fees, problems during the ticketing process, and the quality of customer service. This score is our best indicator of the provider's quality and reliability.

Most accurate provider: When it comes to deals on Des Moines-Guadalajara flights, users find the pricing of eDreams to be most consistent on Cheapflights vs. eDreams Users can find the same prices on Des Moines-Guadalajara flight deals on Cheapflights vs. eDreams >95% of the time. Price accuracy is based on data collected from Des Moines-Guadalajara flight searches over the past month and is updated monthly.
Most trusted provider: When it comes to deals on Des Moines-Guadalajara flights, Cheapflights users trust eDreams the most. eDreams has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for Des Moines-Guadalajara flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.

Best time to book a flight from Des Moines to Guadalajara

Have a flexible travel schedule? Discover the best time to fly to Guadalajara from Des Moines with our price prediction graph.

Estimated round-trip price

Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Des Moines to Guadalajara

What is the cheapest month to book a flight from Des Moines to Guadalajara?

Currently, March is the cheapest month in which you can book a flight from Des Moines to Guadalajara (average of $291). Flying from Des Moines to Guadalajara in July is currently the most expensive (average of $578). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

Reviews of airlines servicing Guadalajara

Peruse reviews from past customers who have flown with United Airlines and American Airlines from Des Moines to Guadalajara to help guide your decision. You can also see how each airline stacks up in terms of entertainment options, comfort, food, crew/service, and boarding process.

United Airlines

7.4

Good

9,017 reviews

Reviews

1 / 20

2.0

Mediocre

Sebrena,Oct 2025

IAH - RSW

The worst that I have ever experienced in my life so bad if it was free I'm not ever going to use your Airline again I dont believe ..... very disappointed 😞 😔0000000000000

United Airlines

7.4

Good

9,017 reviews

United Airlines

7.4

Good

9,017 reviews

Reviews

1 / 20

2.0

Mediocre

Sebrena,Oct 2025

IAH - RSW

The worst that I have ever experienced in my life so bad if it was free I'm not ever going to use your Airline again I dont believe ..... very disappointed 😞 😔0000000000000

American Airlines

7.2

Good

11,051 reviews

United Airlines

7.4

Good

9,017 reviews

Reviews

1 / 20

2.0

Mediocre

Sebrena,Oct 2025

IAH - RSW

The worst that I have ever experienced in my life so bad if it was free I'm not ever going to use your Airline again I dont believe ..... very disappointed 😞 😔0000000000000

Related info for your journey

What are the cheapest airlines flying from Des Moines to Guadalajara round-trip?
According to our current data, American Airlines ($518), and United Airlines ($521) offers the cheapest pricing from Des Moines to Guadalajara. Users have found that American Airlines is 18% cheaper than the other options available to this destination.
Can I find deals for flights from Des Moines to Guadalajara that include hotel bookings?
Yes. In addition to deals on Des Moines to Guadalajara flights, Cheapflights offers vacation packages that include both flights and hotel.
How can I find direct flights from Des Moines to Guadalajara?
After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Des Moines to Guadalajara.
Can I find deals for business class flights from Des Moines to Guadalajara?
Yes. Cheapflights offers flight deals from Des Moines to Guadalajara by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.
What is the cheapest month to book a flight from Des Moines to Guadalajara?
Currently, March is the cheapest month in which you can book a flight from Des Moines to Guadalajara (average of $291). Flying from Des Moines to Guadalajara in July is currently the most expensive (average of $578). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Tlaquepaque

Zapopan

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Other flights to Guadalajara

Top 2 airlines flying from Des Moines to Guadalajara

Airline	Cheapest	Average	Flexibility	On-time
American Airlines	Cheapest$518	Average$645	FlexibilityNo cancel fee	On-time71%
United Airlines	Cheapest$521	Average$691	FlexibilityNo cancel fee	On-time69%

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$137+ Cheap flights from Des Moines (DSM) to Guadalajara (GDL)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 1/12. Fares are subject to change and may not be available on all flights or dates of travel.

Find cheap flights from Des Moines to Guadalajara with Cheapflights

1. Tell us where you want to go

2. Select your favorite providers

3. Compare prices and book

Cheap flight deals from Des Moines to Guadalajara

Most accurate provider

Most trusted provider

Round-trip from

One-way from

Popular in

Cheapest in

Average price

Find flight deals from Des Moines to Guadalajara

Cheapest flights from Des Moines to GuadalajaraExplore the most affordable flight options available from Des Moines to Guadalajara. Find the lowest fares from popular airlines and budget airlines, with prices last updated on November 14, 2025.

Explore the most affordable flight options available from Des Moines to Guadalajara. Find the lowest fares from popular airlines and budget airlines, with prices last updated on November 14, 2025.

Cheapflights Fare Finder

Use the filters below to find and compare flights from Des Moines to Guadalajara that are best for you.

Compare providers for flights from Des Moines to Guadalajara

Provider information is updated monthly. Please note that these providers often have deals for this flight, but the availability may vary on a day-by-day basis on Cheapflights.

Use the table below to compare price accuracy, trust ratings, and cancellation policies for each provider offering flight deals from Des Moines to Guadalajara in November.

Best time to book a flight from Des Moines to Guadalajara

Have a flexible travel schedule? Discover the best time to fly to Guadalajara from Des Moines with our price prediction graph.

Cheapflights Insights

Everything you need to know about your flight from Des Moines to Guadalajara

What is the cheapest month to book a flight from Des Moines to Guadalajara?

Reviews of airlines servicing Guadalajara

Peruse reviews from past customers who have flown with United Airlines and American Airlines from Des Moines to Guadalajara to help guide your decision. You can also see how each airline stacks up in terms of entertainment options, comfort, food, crew/service, and boarding process.

Related info for your journey

Find useful and relevant information for your journey from Des Moines to Guadalajara. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

What are the cheapest airlines flying from Des Moines to Guadalajara round-trip?

Can I find deals for flights from Des Moines to Guadalajara that include hotel bookings?

How can I find direct flights from Des Moines to Guadalajara?

Can I find deals for business class flights from Des Moines to Guadalajara?

What is the cheapest month to book a flight from Des Moines to Guadalajara?

Traveling to a place near Guadalajara?

Browse thousands of different options on Cheapflights for your next trip

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Alternative routes for Des Moines to Guadalajara

See prices for flight routes from nearby airports that may be better suited for you.

Top 2 airlines flying from Des Moines to Guadalajara

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Cheapest flights from Des Moines to Guadalajara
Explore the most affordable flight options available from Des Moines to Guadalajara. Find the lowest fares from popular airlines and budget airlines, with prices last updated on November 14, 2025.