What are the cheapest airlines flying from Des Moines to Guadalajara round-trip?

According to our current data, United Airlines ($459), and American Airlines ($502) offers the cheapest pricing from Des Moines to Guadalajara. Users have found that United Airlines is 29% cheaper than the other options available to this destination.

What is the cheapest day to fly from Des Moines to Guadalajara?

Travelers seeking maximum savings on their Des Moines to Guadalajara flight should consider departing on Wednesday afternoons when fares are most often at their lowest. Friday evenings flights should be avoided if possible as fares are typically the most expensive at this time.

In terms of precipitation, rainfall in Guadalajara ranges from 0.0 - 9.4 inches per month. July is typically the wettest month, when rainfall can reach 9.4 in. February is typically the driest time to visit Guadalajara when rainfall is around 0.0 in.

If weather is an important factor for your trip to Guadalajara, use this chart to help with planning. For those seeking warmer temperatures, June is the ideal time of year to visit, when temperatures reach an average of 73.4 F. Travelers looking to avoid the cold should look outside of January, when temperatures are typically at their lowest (around 59.0 F).

What is the cheapest day to fly round-trip from Des Moines to Guadalajara?

Friday is generally a great day to depart. Flying on this day could help you save up to 34%.

What is the cheapest month to fly from Des Moines to Guadalajara?

Flights from Des Moines to Guadalajara lean towards being more expensive in December. Prices are generally better when you fly from Des Moines to Guadalajara in September, with the cheapest ticket starting at $502.

What is the cheapest time of day to fly from DSM to GDL?

It’s typically best to fly out from Des Moines to Guadalajara in the morning. Doing so could potentially save you 28% on the flight price compared to flying in the afternoon, which is usually more expensive.

Can I find deals for flights from Des Moines to Guadalajara that include hotel bookings?

Yes. In addition to deals on Des Moines to Guadalajara flights, Cheapflights offers vacation packages that include both flights and hotel.

How can I find direct flights from Des Moines to Guadalajara?

After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Des Moines to Guadalajara.

Can I find deals for business class flights from Des Moines to Guadalajara?

Yes. Cheapflights offers flight deals from Des Moines to Guadalajara by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

$271+ Flights from Des Moines to Guadalajara

Q: How much does it cost to fly round-trip from Des Moines to Guadalajara?

Airfare is below average for this route at the moment. Des Moines to Guadalajara flights typically cost between $547 and $592 in October. The cheapest round-trip price found within the last 3 days was $414 on Multiple Airlines (Oct 3-Oct 10).

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Cheap flight deals from Des Moines to Guadalajara

Round-trip from	$414 (Kiwi.com)
One-way from	$271 (Kiwi.com)
Popular in	December
Cheapest in	September
Average price	$573

From Des Moines to Guadalajara Miguel Hidal

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One-way flight from Des Moines to Guadalajara Miguel Hidal

Search Deals

Highest demand for flights based on searches. 13% potential increase in price ($104 potential increase over avg. RT price).

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Cheapest flight prices on average. 5% potential price decrease ($32 potential savings vs. average RT price).

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Average for round-trip flights in August 2025

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Find flight deals from Des Moines to Guadalajara

Cheapest flights from Des Moines to Guadalajara
Explore the most affordable flight options available from Des Moines to Guadalajara. Find the lowest fares from popular airlines and budget airlines, with prices last updated on août 20, 2025.

ven. 10/33:40 pmDSM - GDL

1 stop26h 28mMultiple Airlines

ven. 10/1010:20 amGDL - DSM

1 stop11h 17mMultiple Airlines

Deal found 8/19

$414

jeu. 10/210:41 amDSM - GDL

2 stops27h 35mMultiple Airlines

jeu. 10/910:20 amGDL - DSM

1 stop11h 20mMultiple Airlines

Deal found 8/18

$441

Best flights from Des Moines to Guadalajara
Discover carefully curated flight deals from Des Moines to Guadalajara that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated août 20, 2025.

ven. 10/33:40 pmDSM - GDL

1 stop26h 28mMultiple Airlines

ven. 10/1010:20 amGDL - DSM

1 stop11h 17mMultiple Airlines

Deal found 8/19

$414

jeu. 10/210:41 amDSM - GDL

2 stops27h 35mMultiple Airlines

jeu. 10/910:20 amGDL - DSM

1 stop11h 20mMultiple Airlines

Deal found 8/18

$441

Last-minute flights from Des Moines to Guadalajara
Discover last-minute flight deals from Des Moines to Guadalajara. Data last updated août 20, 2025 and is based on user searches.

dim. 8/247:15 pmDSM - GDL

3 stops28h 08mMultiple Airlines

mer. 9/38:50 pmGDL - DSM

2 stops24h 51mMultiple Airlines

Deal found 8/18

$549

mer. 8/276:00 pmDSM - GDL

2 stops20h 12mMultiple Airlines

jeu. 9/410:20 amGDL - DSM

1 stop11h 21mMultiple Airlines

Deal found 8/20

$522

sam. 9/139:34 amDSM - GDL

1 stop14h 50mAmerican Airlines

sam. 9/206:00 amGDL - DSM

1 stop8h 24mAmerican Airlines

Deal found 8/20

$590

ven. 9/193:30 pmDSM - GDL

1 stop29h 45mMultiple Airlines

dim. 9/2810:20 amGDL - DSM

1 stop11h 21mMultiple Airlines

Deal found 8/20

$462

jeu. 9/258:00 amDSM - GDL

2 stops35h 30mMultiple Airlines

mer. 10/15:03 pmGDL - DSM

1 stop20h 50mMultiple Airlines

Deal found 8/19

$503

jeu. 9/252:25 pmDSM - GDL

2 stops15h 46mFrontier

mer. 10/17:12 pmGDL - DSM

2 stops17h 28mFrontier

Deal found 8/19

$602

ven. 9/262:22 pmDSM - GDL

2 stops29h 58mMultiple Airlines

jeu. 10/910:20 amGDL - DSM

1 stop11h 20mMultiple Airlines

Deal found 8/20

$480

ven. 9/266:12 pmDSM - GDL

1 stop6h 12mAmerican Airlines

jeu. 10/93:29 pmGDL - DSM

1 stop6h 27mAmerican Airlines

Deal found 8/20

$545

ven. 9/262:25 pmDSM - GDL

2 stops15h 46mFrontier

jeu. 10/99:01 pmGDL - DSM

2 stops15h 51mFrontier

Deal found 8/20

$553

One-way flights from Des Moines to Guadalajara
Search for one-way flight options from Des Moines to Guadalajara. Find affordable one-way fares based on user searches. Data last updated août 20, 2025.

jeu. 8/282:14 pmDSM - GDL

1 stop29h 16mMultiple Airlines

Deal found 8/19

$271

lun. 8/253:40 pmDSM - GDL

2 stops29h 16mMultiple Airlines

Deal found 8/19

$277

sam. 12/611:00 amDSM - GDL

3 stops50h 45mMultiple Airlines

Deal found 8/20

$310

sam. 12/61:39 pmDSM - GDL

1 stop9h 51mAmerican Airlines

Deal found 8/20

$320

sam. 12/66:50 pmDSM - GDL

2 stops19h 40mUnited Airlines

Deal found 8/20

$369

mer. 8/276:00 pmDSM - GDL

3 stops49h 30mMultiple Airlines

Deal found 8/19

$379

mer. 8/2711:23 amDSM - GDL

2 stops12h 50mDelta

Deal found 8/19

$394

Cheapflights Fare Finder

Use the filters below to find and compare flights from Des Moines to Guadalajara that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Des MoinesGuadalajara

DSM - GDL

DSMGDL

Des Moines

ven. 10/3

3:40 pm-5:08 pm

1 stop26h 28m

Guadalajara Miguel Hidal

ven. 10/10

10:20 am-10:37 pm

1 stop11h 17m

$414

Des MoinesGuadalajara

DSM - GDL

DSMGDL

Des Moines

jeu. 10/2

10:41 am-1:16 pm

2 stops27h 35m

Guadalajara Miguel Hidal

jeu. 10/9

10:20 am-10:40 pm

1 stop11h 20m

$441

Des MoinesGuadalajara

DSM - GDL

DSMGDL

Des Moines

jeu. 8/28

2:14 pm-6:30 pm

1 stop29h 16m

$271

Des MoinesGuadalajara

DSM - GDL

DSMGDL

Des Moines

lun. 8/25

3:40 pm-7:56 pm

2 stops29h 16m

$277

Des MoinesGuadalajara

DSM - GDL

DSMGDL

Des Moines

sam. 12/6

11:00 am-1:45 pm

3 stops50h 45m

$310

Des MoinesGuadalajara

DSM - GDL

DSMGDL

Des Moines

sam. 12/6

1:39 pm-11:30 pm

1 stop9h 51m

$320

Des MoinesGuadalajara

DSM - GDL

DSMGDL

Des Moines

sam. 12/6

6:50 pm-2:30 pm

2 stops19h 40m

$369

Des MoinesGuadalajara

DSM - GDL

DSMGDL

Des Moines

mer. 8/27

6:00 pm-6:30 pm

3 stops49h 30m

$379

Des MoinesGuadalajara

DSM - GDL

DSMGDL

Des Moines

mer. 8/27

5:30 am-12:48 pm

1 stop8h 18m

$394

Flights are sorted by cheapest round-trip flights first.

Deals found on 8/19

Best time to book a flight from Des Moines to Guadalajara

Have a flexible travel schedule? Discover the best time to fly to Guadalajara from Des Moines with our price prediction graph.

Estimated round-trip price

Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Des Moines to Guadalajara

What is the cheapest month to book a flight from Des Moines to Guadalajara?

Currently, February is the cheapest month in which you can book a flight from Des Moines to Guadalajara (average of $265). Flying from Des Moines to Guadalajara in December is currently the most expensive (average of $492). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

How much does it cost to fly round-trip from Des Moines to Guadalajara?

Reviews of airlines servicing Guadalajara

Peruse reviews from past customers who have flown with United Airlines and American Airlines from Des Moines to Guadalajara to help guide your decision. You can also see how each airline stacks up in terms of entertainment options, comfort, food, crew/service, and boarding process.

United Airlines

7.4

Good

8,928 reviews

Reviews

1 / 20

4.0

Okay

Thomas,Mar 2025

SFO - TPE

When I asked for an extra snack, I got an unhappy look from the stewardess. Geez, does one extra snack really affect the bottom line??

United Airlines

7.4

Good

8,928 reviews

United Airlines

7.4

Good

8,928 reviews

Reviews

1 / 20

4.0

Okay

Thomas,Mar 2025

SFO - TPE

When I asked for an extra snack, I got an unhappy look from the stewardess. Geez, does one extra snack really affect the bottom line??

American Airlines

7.2

Good

10,000 reviews

United Airlines

7.4

Good

8,928 reviews

Reviews

1 / 20

4.0

Okay

Thomas,Mar 2025

SFO - TPE

When I asked for an extra snack, I got an unhappy look from the stewardess. Geez, does one extra snack really affect the bottom line??

Related info for your journey

What are the cheapest airlines flying from Des Moines to Guadalajara round-trip?
According to our current data, United Airlines ($459), and American Airlines ($502) offers the cheapest pricing from Des Moines to Guadalajara. Users have found that United Airlines is 29% cheaper than the other options available to this destination.
Can I find deals for flights from Des Moines to Guadalajara that include hotel bookings?
Yes. In addition to deals on Des Moines to Guadalajara flights, Cheapflights offers vacation packages that include both flights and hotel.
How can I find direct flights from Des Moines to Guadalajara?
After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Des Moines to Guadalajara.
Can I find deals for business class flights from Des Moines to Guadalajara?
Yes. Cheapflights offers flight deals from Des Moines to Guadalajara by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.
What is the cheapest month to book a flight from Des Moines to Guadalajara?
Currently, February is the cheapest month in which you can book a flight from Des Moines to Guadalajara (average of $265). Flying from Des Moines to Guadalajara in December is currently the most expensive (average of $492). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Tlaquepaque

Zapopan

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Top 2 airlines flying from Des Moines to Guadalajara

Airline	Cheapest	Average	Flexibility	On-time
United Airlines	Cheapest$459	Average$629	FlexibilityNo cancel fee	On-time69%
American Airlines	Cheapest$502	Average$627	FlexibilityNo cancel fee	On-time71%

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$271+ Cheap flights from Des Moines (DSM) to Guadalajara (GDL)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 8/28. Fares are subject to change and may not be available on all flights or dates of travel.

Find cheap flights from Des Moines to Guadalajara with Cheapflights

1. Tell us where you want to go

2. Select your favorite providers

3. Compare prices and book

Cheap flight deals from Des Moines to Guadalajara

Round-trip from

One-way from

Popular in

Cheapest in

Average price

Find flight deals from Des Moines to Guadalajara

Cheapest flights from Des Moines to GuadalajaraExplore the most affordable flight options available from Des Moines to Guadalajara. Find the lowest fares from popular airlines and budget airlines, with prices last updated on août 20, 2025.

Explore the most affordable flight options available from Des Moines to Guadalajara. Find the lowest fares from popular airlines and budget airlines, with prices last updated on août 20, 2025.

Cheapflights Fare Finder

Use the filters below to find and compare flights from Des Moines to Guadalajara that are best for you.

Best time to book a flight from Des Moines to Guadalajara

Have a flexible travel schedule? Discover the best time to fly to Guadalajara from Des Moines with our price prediction graph.

Cheapflights Insights

Everything you need to know about your flight from Des Moines to Guadalajara

What is the cheapest month to book a flight from Des Moines to Guadalajara?

How much does it cost to fly round-trip from Des Moines to Guadalajara?

Reviews of airlines servicing Guadalajara

Peruse reviews from past customers who have flown with United Airlines and American Airlines from Des Moines to Guadalajara to help guide your decision. You can also see how each airline stacks up in terms of entertainment options, comfort, food, crew/service, and boarding process.

Related info for your journey

Find useful and relevant information for your journey from Des Moines to Guadalajara. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

What are the cheapest airlines flying from Des Moines to Guadalajara round-trip?

Can I find deals for flights from Des Moines to Guadalajara that include hotel bookings?

How can I find direct flights from Des Moines to Guadalajara?

Can I find deals for business class flights from Des Moines to Guadalajara?

What is the cheapest month to book a flight from Des Moines to Guadalajara?

Traveling to a place near Guadalajara?

Browse thousands of different options on Cheapflights for your next trip

Toggle through the tabs below to find thousands of options on Cheapflights for your next trip.

Alternative routes for Des Moines to Guadalajara

See prices for flight routes from nearby airports that may be better suited for you.

Top 2 airlines flying from Des Moines to Guadalajara

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Book with Flexibility

Travel Smart

Cheapest flights from Des Moines to Guadalajara
Explore the most affordable flight options available from Des Moines to Guadalajara. Find the lowest fares from popular airlines and budget airlines, with prices last updated on août 20, 2025.