$256+ Cheap flights from Des Moines (DSM) to Guadalajara (GDL)
This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 6/1. Fares are subject to change and may not be available on all flights or dates of travel.
DSM — GDL
Mar 15 — Mar 221
1 adult, Economy
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Find cheap flights from Des Moines to Guadalajara with Cheapflights
1. Tell us where you want to go
Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”2. Select your favorite providers
We find the providers serving your travel needs. Choose up to four travel providers to compare side-by-side for flights, hotels, or car rentals.3. Compare prices and book
Review each provider’s pricing and select the best option for you! Book through your favorite provider’s website for a seamless experience.Cheap flight deals from Des Moines to Guadalajara
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Cheapest flights from Des Moines to GuadalajaraExplore the most affordable flight options available from Des Moines to Guadalajara. Find the lowest fares from popular airlines and budget airlines, with prices last updated on February 13, 2026.
Explore the most affordable flight options available from Des Moines to Guadalajara. Find the lowest fares from popular airlines and budget airlines, with prices last updated on February 13, 2026.
This Kiwi.com deal was found by Cheapflights users on 2/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 5/48:15 pm
DSM
- GDL
2 stops19h 55m
Multiple Airlines
Fri 5/2210:25 am
GDL
- DSM
1 stop9h 27m
Multiple Airlines
Deal found 2/12![Multiple Airlines logo]()
$453
This Kiwi.com deal was found by Cheapflights users on 2/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 5/110:14 pm
DSM
- GDL
2 stops31h 41m
Multiple Airlines
Fri 5/2210:25 am
GDL
- DSM
1 stop9h 27m
Multiple Airlines
Deal found 2/12![Multiple Airlines logo]()
$454
This Kiwi.com deal was found by Cheapflights users on 2/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 5/48:15 pm
DSM
- GDL
2 stops19h 55m
Multiple Airlines
Mon 5/1810:25 am
GDL
- DSM
1 stop11h 08m
Multiple Airlines
Deal found 2/12![Multiple Airlines logo]()
$464
This Kiwi.com deal was found by Cheapflights users on 2/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 5/110:14 pm
DSM
- GDL
2 stops31h 41m
Multiple Airlines
Mon 5/1810:25 am
GDL
- DSM
1 stop11h 08m
Multiple Airlines
Deal found 2/12![Multiple Airlines logo]()
$465
This Kiwi.com deal was found by Cheapflights users on 2/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 5/110:14 pm
DSM
- GDL
1 stop19h 08m
Multiple Airlines
Thu 5/2110:25 am
GDL
- DSM
1 stop9h 19m
Multiple Airlines
Deal found 2/12![Multiple Airlines logo]()
$468
This Kiwi.com deal was found by Cheapflights users on 2/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 3/278:21 pm
DSM
- GDL
2 stops42h 17m
Multiple Airlines
Fri 4/310:25 am
GDL
- DSM
1 stop9h 30m
Multiple Airlines
Deal found 2/10![Multiple Airlines logo]()
$484
This Kiwi.com deal was found by Cheapflights users on 2/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 5/110:14 pm
DSM
- GDL
1 stop19h 08m
Multiple Airlines
Wed 5/208:30 am
GDL
- DSM
2 stops28h 49m
Multiple Airlines
Deal found 2/12![Multiple Airlines logo]()
$497
This Kiwi.com deal was found by Cheapflights users on 2/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 5/110:14 pm
DSM
- GDL
1 stop19h 08m
Multiple Airlines
Sat 5/168:30 am
GDL
- DSM
2 stops32h 31m
Multiple Airlines
Deal found 2/12![Multiple Airlines logo]()
$506
This Kiwi.com deal was found by Cheapflights users on 2/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 5/77:45 am
DSM
- GDL
2 stops28h 55m
Multiple Airlines
Thu 5/2110:25 am
GDL
- DSM
1 stop9h 19m
Multiple Airlines
Deal found 2/12![Multiple Airlines logo]()
$515
Best flights from Des Moines to GuadalajaraDiscover carefully curated flight deals from Des Moines to Guadalajara that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated February 13, 2026.
Discover carefully curated flight deals from Des Moines to Guadalajara that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated February 13, 2026.
This Kiwi.com deal was found by Cheapflights users on 2/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 3/278:21 pm
DSM
- GDL
2 stops25h 49m
Multiple Airlines
Fri 4/310:25 am
GDL
- DSM
1 stop9h 30m
Multiple Airlines
Deal found 2/10![Multiple Airlines logo]()
$485
This American Airlines deal was found by Cheapflights users on 2/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 3/2711:17 am
DSM
- GDL
1 stop12h 33m
American Airlines
Fri 4/31:12 pm
GDL
- DSM
1 stop20h 32m
American Airlines
Deal found 2/10![American Airlines logo]()
$541
This Delta deal was found by Cheapflights users on 2/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 8/117:00 am
DSM
- GDL
2 stops16h 03m
Delta
Wed 8/268:02 am
GDL
- DSM
2 stops13h 24m
Delta
Deal found 2/12![Delta logo]()
$583
This Kiwi.com deal was found by Cheapflights users on 2/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 3/288:21 pm
DSM
- GDL
1 stop20h 45m
Multiple Airlines
Sat 4/46:10 am
GDL
- DSM
2 stops31h 21m
Multiple Airlines
Deal found 2/10![Multiple Airlines logo]()
$560
This American Airlines deal was found by Cheapflights users on 2/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 3/293:26 pm
DSM
- GDL
1 stop8h 24m
American Airlines
Fri 4/171:29 pm
GDL
- DSM
1 stop9h 30m
American Airlines
Deal found 2/9![American Airlines logo]()
$564
This Delta deal was found by Cheapflights users on 2/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 8/117:00 am
DSM
- GDL
2 stops11h 50m
Delta
Thu 8/2712:41 pm
GDL
- DSM
1 stop8h 45m
Delta
Deal found 2/12![Delta logo]()
$583
This American Airlines deal was found by Cheapflights users on 2/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 3/283:26 pm
DSM
- GDL
1 stop8h 24m
American Airlines
Sat 4/46:15 am
GDL
- DSM
1 stop11h 42m
American Airlines
Deal found 2/11![American Airlines logo]()
$579
This Delta deal was found by Cheapflights users on 2/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 8/117:00 am
DSM
- GDL
2 stops11h 50m
Delta
Tue 8/258:02 am
GDL
- DSM
2 stops13h 24m
Delta
Deal found 2/12![Delta logo]()
$583
This Delta deal was found by Cheapflights users on 2/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 5/47:00 am
DSM
- GDL
2 stops10h 50m
Delta
Tue 5/197:45 am
GDL
- DSM
2 stops13h 47m
Delta
Deal found 2/12![Delta logo]()
$583
Last-minute flights from Des Moines to GuadalajaraDiscover last-minute flight deals from Des Moines to Guadalajara. Data last updated February 13, 2026 and is based on user searches.
Discover last-minute flight deals from Des Moines to Guadalajara. Data last updated February 13, 2026 and is based on user searches.
This Kiwi.com deal was found by Cheapflights users on 2/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 3/278:21 pm
DSM
- GDL
2 stops42h 17m
Multiple Airlines
Fri 4/310:25 am
GDL
- DSM
1 stop9h 30m
Multiple Airlines
Deal found 2/10![Multiple Airlines logo]()
$484
This American Airlines deal was found by Cheapflights users on 2/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 3/2711:17 am
DSM
- GDL
1 stop12h 33m
American Airlines
Fri 4/31:12 pm
GDL
- DSM
1 stop20h 32m
American Airlines
Deal found 2/10![American Airlines logo]()
$541
This Kiwi.com deal was found by Cheapflights users on 2/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 3/288:21 pm
DSM
- GDL
1 stop20h 45m
Multiple Airlines
Sat 4/46:10 am
GDL
- DSM
2 stops31h 21m
Multiple Airlines
Deal found 2/10![Multiple Airlines logo]()
$560
This American Airlines deal was found by Cheapflights users on 2/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 3/283:26 pm
DSM
- GDL
1 stop8h 24m
American Airlines
Sat 4/46:15 am
GDL
- DSM
1 stop11h 42m
American Airlines
Deal found 2/11![American Airlines logo]()
$579
This Kiwi.com deal was found by Cheapflights users on 2/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 3/296:30 am
DSM
- GDL
2 stops55h 06m
Multiple Airlines
Fri 4/1710:25 am
GDL
- DSM
1 stop9h 59m
Multiple Airlines
Deal found 2/9![Multiple Airlines logo]()
$539
This American Airlines deal was found by Cheapflights users on 2/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 3/293:26 pm
DSM
- GDL
1 stop8h 24m
American Airlines
Fri 4/171:29 pm
GDL
- DSM
1 stop9h 30m
American Airlines
Deal found 2/9![American Airlines logo]()
$564
One-way flights from Des Moines to GuadalajaraSearch for one-way flight options from Des Moines to Guadalajara. Find affordable one-way fares based on user searches. Data last updated February 13, 2026.
Search for one-way flight options from Des Moines to Guadalajara. Find affordable one-way fares based on user searches. Data last updated February 13, 2026.
This eDestinos deal was found by Cheapflights users on 2/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure eDestinos is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 6/18:47 pm
DSM
- GDL
1 stop24h 14m
Multiple Airlines
Deal found 2/11![Multiple Airlines logo]()
$256
This Priceline deal was found by Cheapflights users on 2/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Priceline is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 3/118:21 pm
DSM
- GDL
1 stop20h 04m
Frontier
Deal found 2/12![Frontier logo]()
$265
This Kiwi.com deal was found by Cheapflights users on 2/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 3/118:21 pm
DSM
- GDL
2 stops23h 09m
Multiple Airlines
Deal found 2/12![Multiple Airlines logo]()
$273
This Priceline deal was found by Cheapflights users on 2/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Priceline is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 6/18:21 pm
DSM
- GDL
1 stop20h 59m
Frontier
Deal found 2/11![Frontier logo]()
$286
This Kiwi.com deal was found by Cheapflights users on 2/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 6/31:45 pm
DSM
- GDL
1 stop29h 30m
Multiple Airlines
Deal found 2/11![Multiple Airlines logo]()
$296
This American Airlines deal was found by Cheapflights users on 2/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 3/293:26 pm
DSM
- GDL
1 stop8h 24m
American Airlines
Deal found 2/9![American Airlines logo]()
$297
This Priceline deal was found by Cheapflights users on 2/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Priceline is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 3/138:21 pm
DSM
- GDL
1 stop20h 04m
Frontier
Deal found 2/12![Frontier logo]()
$317
This Aeromexico deal was found by Cheapflights users on 2/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Aeromexico is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 6/35:29 am
DSM
- GDL
2 stops28h 36m
Aeromexico
Deal found 2/11![Aeromexico logo]()
$329
Find flight deals from Des Moines to Guadalajara
Discover tips and strategies to find the most affordable flight options for your journey from Des Moines (DSM) to Guadalajara (GDL). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated February 13, 2026.
Most accurate provider | FlightHub 3 stars |
|---|---|
Most trusted provider | FlightHub 3 stars |
Round-trip from | $453 (Kiwi.com) |
One-way from | $256 (eDestinos) |
Popular in | March |
Cheapest in | May |
Average price | $678 |
Cheapflights Fare Finder
Customize your flight search to find flights from Des Moines to Guadalajara that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated February 13, 2026.
Use the filters below to find and compare flights from Des Moines to Guadalajara that are best for you.
Fly from
Des Moines
Fly to
Guadalajara
Route
Depart
Return
Price
Des MoinesGuadalajara
DSM - GDL
DSMGDL
Des Moines
Fri 3/27
8:21 pm-9:10 pm
2 stops25h 49m
Guadalajara Miguel Hidal
Fri 4/3
10:25 am-8:55 pm
1 stop9h 30m
$485
Des MoinesGuadalajara
DSM - GDL
DSMGDL
Des Moines
Fri 3/27
11:17 am-10:50 pm
1 stop12h 33m
Guadalajara Miguel Hidal
Fri 4/3
1:12 pm-10:44 am
1 stop20h 32m
$541
Des MoinesGuadalajara
DSM - GDL
DSMGDL
Des Moines
Sat 3/28
8:21 pm-4:06 pm
1 stop20h 45m
Guadalajara Miguel Hidal
Sat 4/4
6:10 am-2:31 pm
2 stops31h 21m
$560
Des MoinesGuadalajara
DSM - GDL
DSMGDL
Des Moines
Sun 3/29
3:26 pm-10:50 pm
1 stop8h 24m
Guadalajara Miguel Hidal
Fri 4/17
1:29 pm-11:59 pm
1 stop9h 30m
$564
Des MoinesGuadalajara
DSM - GDL
DSMGDL
Des Moines
Sat 3/28
3:26 pm-10:50 pm
1 stop8h 24m
Guadalajara Miguel Hidal
Sat 4/4
6:15 am-6:57 pm
1 stop11h 42m
$579
Des MoinesGuadalajara
DSM - GDL
DSMGDL
Des Moines
Tue 8/11
7:00 am-10:03 pm
2 stops16h 03m
Guadalajara Miguel Hidal
Wed 8/26
8:02 am-10:26 pm
2 stops13h 24m
$583
Des MoinesGuadalajara
DSM - GDL
DSMGDL
Des Moines
Tue 8/11
7:00 am-5:50 pm
2 stops11h 50m
Guadalajara Miguel Hidal
Thu 8/27
12:41 pm-10:26 pm
1 stop8h 45m
$583
Des MoinesGuadalajara
DSM - GDL
DSMGDL
Des Moines
Tue 8/11
7:00 am-5:50 pm
2 stops11h 50m
Guadalajara Miguel Hidal
Tue 8/25
8:02 am-10:26 pm
2 stops13h 24m
$583
Des MoinesGuadalajara
DSM - GDL
DSMGDL
Des Moines
Mon 5/4
7:00 am-4:50 pm
2 stops10h 50m
Guadalajara Miguel Hidal
Tue 5/19
7:45 am-10:32 pm
2 stops13h 47m
$583
Des MoinesGuadalajara
DSM - GDL
DSMGDL
Des Moines
Mon 6/1
8:47 pm-8:01 pm
1 stop24h 14m
$256
Showing 1-10 of 15 results
Compare providers for flights from Des Moines to Guadalajara
Provider information is updated monthly. Please note that these providers often have deals for this flight, but the availability may vary on a day-by-day basis on Cheapflights.
Use the table below to compare price accuracy, trust ratings, and cancellation policies for each provider offering flight deals from Des Moines to Guadalajara in February.
| Provider | Price Accuracy | Trust Score* |
|---|---|---|
| Price Accuracy1 star | Trust Score*3 stars | |
| Price Accuracy3 stars | Trust Score*3 stars |
- Most accurate provider: When it comes to deals on Des Moines-Guadalajara flights, users find the pricing of FlightHub to be most consistent on Cheapflights vs. FlightHub Users can find the same prices on Des Moines-Guadalajara flight deals on Cheapflights vs. FlightHub >95% of the time. Price accuracy is based on data collected from Des Moines-Guadalajara flight searches over the past month and is updated monthly.
- Most trusted provider: When it comes to deals on Des Moines-Guadalajara flights, Cheapflights users trust FlightHub the most. FlightHub has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for Des Moines-Guadalajara flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.
Best time to book a flight from Des Moines to Guadalajara
Have a flexible travel schedule? Discover the best time to fly to Guadalajara from Des Moines with our price prediction graph.
DSM-GDL
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.
Cheapflights Insights
Everything you need to know about your flight from Des Moines to Guadalajara
What is the cheapest month to book a flight from Des Moines to Guadalajara?
Currently, March is the cheapest month in which you can book a flight from Des Moines to Guadalajara (average of $363). Flying from Des Moines to Guadalajara in June is currently the most expensive (average of $621). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.
How much does it cost to fly round-trip from Des Moines to Guadalajara?
Reviews of airlines servicing Guadalajara
Get insights into the airlines that provide service to Guadalajara. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Guadalajara. Reviews last updated February 13, 2026.
Peruse reviews from past customers who have flown with United Airlines and American Airlines from Des Moines to Guadalajara to help guide your decision. You can also see how each airline stacks up in terms of entertainment options, comfort, food, crew/service, and boarding process.
Food
6.6
Overall
7.4
Comfort
7.3
Boarding
7.7
Entertainment
7.1
Crew
8.1
Reviews
1 / 20
10.0
ExcellentDane,Jan 2026
TYS - IAD
Food
6.6
Overall
7.4
Comfort
7.3
Boarding
7.7
Entertainment
7.1
Crew
8.1
Reviews
1 / 20
10.0
ExcellentDane,Jan 2026
TYS - IAD
Food
6.6
Overall
7.4
Comfort
7.3
Boarding
7.7
Entertainment
7.1
Crew
8.1
Reviews
1 / 20
10.0
ExcellentDane,Jan 2026
TYS - IAD
Related info for your journey
Find useful and relevant information for your journey from Des Moines to Guadalajara. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.
Traveling to a place near Guadalajara?
Book flights to Guadalajara if you plan to visit one of these locationsTlaquepaque
Zapopan
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Other flights to Guadalajara
Explore flights to Guadalajara departing from other origins. Flights are based on user searches made on Cheapflights and were last updated on February 13, 2026.
Des Moines and Guadalajara flights
Browse other Des Moines and Guadalajara flight options. Last updated on February 13, 2026.
Other flights from Des Moines
Browse through other flights departing from Des Moines. Flights are based on user searches made on Cheapflights and were last updated on February 13, 2026.
Popular flight searches
Check out other popular destinations found by fellow travelers in 2026
Top 2 airlines flying from Des Moines to Guadalajara
Discover the top 2 airlines that operate flights from Des Moines to Guadalajara. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated February 13, 2026.
| Airline | Cheapest | Average | Flexibility | On-time |
|---|---|---|---|---|
| Cheapest$536 | Average$645 | FlexibilityNo cancel fee | On-time71% | |
| Cheapest$563 | Average$715 | FlexibilityNo cancel fee | On-time69% |