How long is the flight from Des Moines to Guadalajara?

American Airlines can get you from Des Moines to Guadalajara in just under 6h 32m. Your travel time can differ by up to . Des Moines and Guadalajara are separated by a distance of 1557 mi.

What are the cheapest airlines flying from Des Moines to Guadalajara round-trip?

According to our current data, United Airlines ($459), and American Airlines ($517) offers the cheapest pricing from Des Moines to Guadalajara. Users have found that United Airlines is 28% cheaper than the other options available to this destination.

What is the cheapest day to fly from Des Moines to Guadalajara?

Travelers seeking maximum savings on their Des Moines to Guadalajara flight should consider departing on Wednesday afternoons when fares are most often at their lowest. Friday evenings flights should be avoided if possible as fares are typically the most expensive at this time.

In terms of precipitation, rainfall in Guadalajara ranges from 0.0 - 9.4 inches per month. July is typically the wettest month, when rainfall can reach 9.4 in. February is typically the driest time to visit Guadalajara when rainfall is around 0.0 in.

If weather is an important factor for your trip to Guadalajara, use this chart to help with planning. For those seeking warmer temperatures, June is the ideal time of year to visit, when temperatures reach an average of 73.4 F. Travelers looking to avoid the cold should look outside of January, when temperatures are typically at their lowest (around 59.0 F).

What is the cheapest time of day to fly from DSM to GDL?

It’s typically best to fly out from Des Moines to Guadalajara in the morning. Doing so could potentially save you 28% on the flight price compared to flying in the afternoon, which is usually more expensive.

Can I find deals for flights from Des Moines to Guadalajara that include hotel bookings?

Yes. In addition to deals on Des Moines to Guadalajara flights, Cheapflights offers vacation packages that include both flights and hotel.

How can I find direct flights from Des Moines to Guadalajara?

After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Des Moines to Guadalajara.

Can I find deals for business class flights from Des Moines to Guadalajara?

Yes. Cheapflights offers flight deals from Des Moines to Guadalajara by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

$179+ Flights from Des Moines to Guadalajara

Home Search by date Vacation packages Hotels Flight deals Car rental Travel tips & news

Find cheap flights from Des Moines to Guadalajara with Cheapflights

1. Tell us where you want to go

Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”

2. Select your favorite providers

We find the providers serving your travel needs. Choose up to four travel providers to compare side-by-side for flights, hotels, or car rentals.

3. Compare prices and book

Review each provider’s pricing and select the best option for you! Book through your favorite provider’s website for a seamless experience.

Cheap flight deals from Des Moines to Guadalajara

Round-trip from	$462 (Kiwi.com)
One-way from	$179 (Kiwi.com)
Popular in	December
Cheapest in	April
Average price	$629

From Des Moines to Guadalajara Miguel Hidal

Search Deals

One-way flight from Des Moines to Guadalajara Miguel Hidal

Search Deals

Highest demand for flights based on searches. 10% potential increase in price ($74 potential increase over avg. RT price).

Search Deals

Cheapest flight prices on average. 3% potential price decrease ($23 potential savings vs. average RT price).

Search Deals

Average for round-trip flights in September 2025

Search Deals

Find flight deals from Des Moines to Guadalajara

Cheapest flights from Des Moines to Guadalajara
Explore the most affordable flight options available from Des Moines to Guadalajara. Find the lowest fares from popular airlines and budget airlines, with prices last updated on setembro 16, 2025.

qua 10/82:37 pmDSM - GDL

1 stop25h 28mMultiple Airlines

ter 10/216:00 amGDL - DSM

2 stops30h 52mMultiple Airlines

Deal found 9/16

$384

dom 10/122:37 pmDSM - GDL

1 stop25h 28mMultiple Airlines

ter 10/216:00 amGDL - DSM

2 stops30h 52mMultiple Airlines

Deal found 9/16

$403

seg 10/133:40 pmDSM - GDL

1 stop26h 28mMultiple Airlines

ter 10/216:00 amGDL - DSM

2 stops30h 52mMultiple Airlines

Deal found 9/16

$414

sex 10/32:25 pmDSM - GDL

1 stop25h 40mMultiple Airlines

ter 10/146:00 amGDL - DSM

2 stops30h 52mMultiple Airlines

Deal found 9/16

$417

qua 10/82:37 pmDSM - GDL

1 stop25h 28mMultiple Airlines

qua 10/1510:20 amGDL - DSM

2 stops28h 24mMultiple Airlines

Deal found 9/16

$418

qui 11/62:32 pmDSM - GDL

2 stops22h 49mMultiple Airlines

qui 11/138:02 amGDL - DSM

1 stop29h 47mMultiple Airlines

Deal found 9/16

$420

qua 10/17:30 amDSM - GDL

1 stop13h 45mMultiple Airlines

ter 10/146:00 amGDL - DSM

2 stops30h 52mMultiple Airlines

Deal found 9/16

$421

qua 10/82:37 pmDSM - GDL

1 stop25h 28mMultiple Airlines

sex 10/1710:20 amGDL - DSM

1 stop11h 17mMultiple Airlines

Deal found 9/16

$428

seg 9/293:30 pmDSM - GDL

1 stop29h 45mMultiple Airlines

ter 10/146:00 amGDL - DSM

2 stops30h 52mMultiple Airlines

Deal found 9/16

$429

qua 10/82:37 pmDSM - GDL

1 stop25h 28mMultiple Airlines

qui 10/1610:20 amGDL - DSM

1 stop11h 20mMultiple Airlines

Deal found 9/16

$440

Best flights from Des Moines to Guadalajara
Discover carefully curated flight deals from Des Moines to Guadalajara that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated setembro 16, 2025.

qua 10/82:37 pmDSM - GDL

1 stop25h 28mMultiple Airlines

qui 10/1610:20 amGDL - DSM

1 stop11h 20mMultiple Airlines

Deal found 9/16

$440

ter 10/146:39 pmDSM - GDL

2 stops20h 51mDelta

ter 10/211:02 pmGDL - DSM

1 stop8h 28mDelta

Deal found 9/16

$536

qua 11/265:26 pmDSM - GDL

1 stop6h 32mAmerican Airlines

ter 12/1612:28 pmGDL - DSM

1 stop10h 31mAmerican Airlines

Deal found 9/14

$545

qua 11/56:05 amDSM - GDL

1 stop6h 31mUnited Airlines

qua 11/125:45 amGDL - DSM

2 stops15h 00mUnited Airlines

Deal found 9/16

$550

qui 10/302:32 pmDSM - GDL

1 stop25h 33mMultiple Airlines

qui 11/63:18 pmGDL - DSM

2 stops31h 22mMultiple Airlines

Deal found 9/15

$486

qui 1/15:07 amDSM - GDL

1 stop6h 23mAmerican Airlines

sex 1/234:45 pmGDL - DSM

1 stop5h 55mAmerican Airlines

Deal found 9/15

$550

qui 10/22:25 pmDSM - GDL

1 stop25h 40mMultiple Airlines

qui 10/1610:20 amGDL - DSM

1 stop11h 20mMultiple Airlines

Deal found 9/16

$511

seg 3/95:15 pmDSM - GDL

2 stops25h 40mDelta

qua 3/116:00 pmGDL - DSM

2 stops15h 23mDelta

Deal found 9/13

$565

sex 2/205:59 pmDSM - GDL

1 stop5h 31mAmerican Airlines

qua 3/46:04 amGDL - DSM

1 stop10h 10mAmerican Airlines

Deal found 9/15

$550

sex 2/207:00 amDSM - GDL

2 stops10h 32mDelta

qua 3/42:18 pmGDL - DSM

1 stop8h 10mDelta

Deal found 9/15

$570

Last-minute flights from Des Moines to Guadalajara
Discover last-minute flight deals from Des Moines to Guadalajara. Data last updated setembro 16, 2025 and is based on user searches.

seg 9/293:30 pmDSM - GDL

1 stop29h 45mMultiple Airlines

ter 10/146:00 amGDL - DSM

2 stops30h 52mMultiple Airlines

Deal found 9/16

$429

qua 10/17:30 amDSM - GDL

1 stop13h 45mMultiple Airlines

ter 10/146:00 amGDL - DSM

2 stops30h 52mMultiple Airlines

Deal found 9/16

$421

sex 10/32:25 pmDSM - GDL

1 stop25h 40mMultiple Airlines

ter 10/146:00 amGDL - DSM

2 stops30h 52mMultiple Airlines

Deal found 9/16

$417

qua 10/82:37 pmDSM - GDL

1 stop25h 28mMultiple Airlines

ter 10/216:00 amGDL - DSM

2 stops30h 52mMultiple Airlines

Deal found 9/16

$384

qua 10/82:37 pmDSM - GDL

1 stop25h 28mMultiple Airlines

qua 10/1510:20 amGDL - DSM

2 stops28h 24mMultiple Airlines

Deal found 9/16

$418

qua 10/82:37 pmDSM - GDL

1 stop25h 28mMultiple Airlines

sex 10/1710:20 amGDL - DSM

1 stop11h 17mMultiple Airlines

Deal found 9/16

$428

qua 10/82:37 pmDSM - GDL

1 stop25h 28mMultiple Airlines

qui 10/1610:20 amGDL - DSM

1 stop11h 20mMultiple Airlines

Deal found 9/16

$440

dom 10/122:37 pmDSM - GDL

1 stop25h 28mMultiple Airlines

ter 10/216:00 amGDL - DSM

2 stops30h 52mMultiple Airlines

Deal found 9/16

$403

seg 10/133:40 pmDSM - GDL

1 stop26h 28mMultiple Airlines

ter 10/216:00 amGDL - DSM

2 stops30h 52mMultiple Airlines

Deal found 9/16

$414

One-way flights from Des Moines to Guadalajara
Search for one-way flight options from Des Moines to Guadalajara. Find affordable one-way fares based on user searches. Data last updated setembro 16, 2025.

sex 12/58:15 pmDSM - GDL

2 stops41h 06mMultiple Airlines

Deal found 9/15

$179

qua 10/17:30 amDSM - GDL

1 stop13h 45mMultiple Airlines

Deal found 9/16

$198

seg 9/293:30 pmDSM - GDL

1 stop29h 45mMultiple Airlines

Deal found 9/16

$206

sex 10/32:25 pmDSM - GDL

1 stop25h 40mMultiple Airlines

Deal found 9/16

$209

qui 10/22:25 pmDSM - GDL

1 stop25h 40mMultiple Airlines

Deal found 9/16

$223

dom 9/286:30 amDSM - GDL

2 stops38h 22mMultiple Airlines

Deal found 9/16

$250

Cheapflights Fare Finder

Use the filters below to find and compare flights from Des Moines to Guadalajara that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Des MoinesGuadalajara

DSM - GDL

DSMGDL

Des Moines

qua 10/8

2:37 pm-3:05 pm

1 stop25h 28m

Guadalajara Miguel Hidal

qui 10/16

10:20 am-10:40 pm

1 stop11h 20m

$440

Des MoinesGuadalajara

DSM - GDL

DSMGDL

Des Moines

qui 10/30

2:32 pm-3:05 pm

1 stop25h 33m

Guadalajara Miguel Hidal

qui 11/6

3:18 pm-10:40 pm

2 stops31h 22m

$486

Des MoinesGuadalajara

DSM - GDL

DSMGDL

Des Moines

qui 10/2

2:25 pm-3:05 pm

1 stop25h 40m

Guadalajara Miguel Hidal

qui 10/16

10:20 am-10:40 pm

1 stop11h 20m

$511

Des MoinesGuadalajara

DSM - GDL

DSMGDL

Des Moines

ter 10/14

6:39 pm-2:30 pm

2 stops20h 51m

Guadalajara Miguel Hidal

ter 10/21

1:02 pm-10:30 pm

1 stop8h 28m

$536

Des MoinesGuadalajara

DSM - GDL

DSMGDL

Des Moines

qua 11/26

5:26 pm-11:58 pm

1 stop6h 32m

Guadalajara Miguel Hidal

ter 12/16

12:28 pm-10:59 pm

1 stop10h 31m

$545

Des MoinesGuadalajara

DSM - GDL

DSMGDL

Des Moines

qua 11/5

6:05 am-12:36 pm

1 stop6h 31m

Guadalajara Miguel Hidal

qua 11/12

5:45 am-8:45 pm

2 stops15h 00m

$550

Des MoinesGuadalajara

DSM - GDL

DSMGDL

Des Moines

qui 1/1

5:07 am-11:30 am

1 stop6h 23m

Guadalajara Miguel Hidal

sex 1/23

4:45 pm-10:40 pm

1 stop5h 55m

$550

Des MoinesGuadalajara

DSM - GDL

DSMGDL

Des Moines

sex 2/20

5:59 pm-11:30 pm

1 stop5h 31m

Guadalajara Miguel Hidal

qua 3/4

6:04 am-4:14 pm

1 stop10h 10m

$550

Des MoinesGuadalajara

DSM - GDL

DSMGDL

Des Moines

seg 3/9

5:15 pm-5:55 pm

2 stops25h 40m

Guadalajara Miguel Hidal

qua 3/11

6:00 pm-10:23 am

2 stops15h 23m

$565

Des MoinesGuadalajara

DSM - GDL

DSMGDL

Des Moines

sex 2/20

7:00 am-5:32 pm

2 stops10h 32m

Guadalajara Miguel Hidal

qua 3/4

2:18 pm-10:28 pm

1 stop8h 10m

$570

Flights are sorted by cheapest round-trip flights first.

Deals found on 9/15

Showing 1-10 of 16 results

Best time to book a flight from Des Moines to Guadalajara

Have a flexible travel schedule? Discover the best time to fly to Guadalajara from Des Moines with our price prediction graph.

Estimated round-trip price

Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Des Moines to Guadalajara

What is the cheapest month to book a flight from Des Moines to Guadalajara?

Currently, February is the cheapest month in which you can book a flight from Des Moines to Guadalajara (average of $265). Flying from Des Moines to Guadalajara in December is currently the most expensive (average of $492). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

Reviews of airlines servicing Guadalajara

Peruse reviews from past customers who have flown with United Airlines and American Airlines from Des Moines to Guadalajara to help guide your decision. You can also see how each airline stacks up in terms of entertainment options, comfort, food, crew/service, and boarding process.

United Airlines

7.4

Good

8,924 reviews

Reviews

1 / 20

4.0

Okay

Thomas,Mar 2025

SFO - TPE

When I asked for an extra snack, I got an unhappy look from the stewardess. Geez, does one extra snack really affect the bottom line??

United Airlines

7.4

Good

8,924 reviews

United Airlines

7.4

Good

8,924 reviews

Reviews

1 / 20

4.0

Okay

Thomas,Mar 2025

SFO - TPE

When I asked for an extra snack, I got an unhappy look from the stewardess. Geez, does one extra snack really affect the bottom line??

American Airlines

7.2

Good

10,000 reviews

United Airlines

7.4

Good

8,924 reviews

Reviews

1 / 20

4.0

Okay

Thomas,Mar 2025

SFO - TPE

When I asked for an extra snack, I got an unhappy look from the stewardess. Geez, does one extra snack really affect the bottom line??

Related info for your journey

How long is the flight from Des Moines to Guadalajara?
American Airlines can get you from Des Moines to Guadalajara in just under 6h 32m. Your travel time can differ by up to . Des Moines and Guadalajara are separated by a distance of 1557 mi.
What are the cheapest airlines flying from Des Moines to Guadalajara round-trip?
According to our current data, United Airlines ($459), and American Airlines ($517) offers the cheapest pricing from Des Moines to Guadalajara. Users have found that United Airlines is 28% cheaper than the other options available to this destination.
Can I find deals for flights from Des Moines to Guadalajara that include hotel bookings?
Yes. In addition to deals on Des Moines to Guadalajara flights, Cheapflights offers vacation packages that include both flights and hotel.
How can I find direct flights from Des Moines to Guadalajara?
After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Des Moines to Guadalajara.
Can I find deals for business class flights from Des Moines to Guadalajara?
Yes. Cheapflights offers flight deals from Des Moines to Guadalajara by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.
What is the cheapest month to book a flight from Des Moines to Guadalajara?
Currently, February is the cheapest month in which you can book a flight from Des Moines to Guadalajara (average of $265). Flying from Des Moines to Guadalajara in December is currently the most expensive (average of $492). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Tlaquepaque

Zapopan

Browse thousands of different options on Cheapflights for your next trip

Alternative routes for Des Moines to Guadalajara

Omaha to Puerto Vallarta flights

Des Moines to Puerto Vallarta flights

Omaha to Guadalajara flights

Cedar Rapids to Puerto Vallarta flights

Moline to Puerto Vallarta flights

Cedar Rapids to Guadalajara flights

Omaha to Aguascalientes flights

Moline to Guadalajara flights

Moline to Aguascalientes flights

Sioux City to Puerto Vallarta flights

Other flights to Guadalajara

Top 2 airlines flying from Des Moines to Guadalajara

Airline	Cheapest	Average	Flexibility	On-time
United Airlines	Cheapest$459	Average$629	FlexibilityNo cancel fee	On-time69%
American Airlines	Cheapest$517	Average$623	FlexibilityNo cancel fee	On-time71%

100% Free

Cheapflights is completely free to use, so you can start saving the moment you arrive.

Book with Flexibility

Our users can plan ahead with confidence and find flights with no change fees

Travel Smart

Millions of people come to us for their flight needs every year. We help make travel planning easy by providing useful insights and data-driven graphs that can inform your decisions.

$179+ Cheap flights from Des Moines (DSM) to Guadalajara (GDL)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 12/5. Fares are subject to change and may not be available on all flights or dates of travel.

Find cheap flights from Des Moines to Guadalajara with Cheapflights

1. Tell us where you want to go

2. Select your favorite providers

3. Compare prices and book

Cheap flight deals from Des Moines to Guadalajara

Round-trip from

One-way from

Popular in

Cheapest in

Average price

Find flight deals from Des Moines to Guadalajara

Cheapest flights from Des Moines to GuadalajaraExplore the most affordable flight options available from Des Moines to Guadalajara. Find the lowest fares from popular airlines and budget airlines, with prices last updated on setembro 16, 2025.

Explore the most affordable flight options available from Des Moines to Guadalajara. Find the lowest fares from popular airlines and budget airlines, with prices last updated on setembro 16, 2025.

Cheapflights Fare Finder

Use the filters below to find and compare flights from Des Moines to Guadalajara that are best for you.

Best time to book a flight from Des Moines to Guadalajara

Have a flexible travel schedule? Discover the best time to fly to Guadalajara from Des Moines with our price prediction graph.

Cheapflights Insights

Everything you need to know about your flight from Des Moines to Guadalajara

What is the cheapest month to book a flight from Des Moines to Guadalajara?

Reviews of airlines servicing Guadalajara

Peruse reviews from past customers who have flown with United Airlines and American Airlines from Des Moines to Guadalajara to help guide your decision. You can also see how each airline stacks up in terms of entertainment options, comfort, food, crew/service, and boarding process.

Related info for your journey

Find useful and relevant information for your journey from Des Moines to Guadalajara. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

How long is the flight from Des Moines to Guadalajara?

What are the cheapest airlines flying from Des Moines to Guadalajara round-trip?

Can I find deals for flights from Des Moines to Guadalajara that include hotel bookings?

How can I find direct flights from Des Moines to Guadalajara?

Can I find deals for business class flights from Des Moines to Guadalajara?

What is the cheapest month to book a flight from Des Moines to Guadalajara?

Traveling to a place near Guadalajara?

Browse thousands of different options on Cheapflights for your next trip

Toggle through the tabs below to find thousands of options on Cheapflights for your next trip.

Alternative routes for Des Moines to Guadalajara

See prices for flight routes from nearby airports that may be better suited for you.

Top 2 airlines flying from Des Moines to Guadalajara

100% Free

Book with Flexibility

Travel Smart

Cheapest flights from Des Moines to Guadalajara
Explore the most affordable flight options available from Des Moines to Guadalajara. Find the lowest fares from popular airlines and budget airlines, with prices last updated on setembro 16, 2025.