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$311+ Cheap flights from Panama to Greenville (GSP)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 10/7. Fares are subject to change and may not be available on all flights or dates of travel.
PTY — GSP
Oct 16 — Oct 231
Thu 10/16
Thu 10/23
1 adult, Economy
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Cheap flight deals from Panama to Greenville

Keep the following information in mind while searching for Panama to Greenville flight deals. Data was last updated September 16, 2025.

Round-trip from

$527
(American Airlines)

One-way from

$311
(Delta)

Popular in

December

Cheapest in

June

Average price

$613
From Panama to Greenville
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One-way flight from Panama to Greenville
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Highest demand for flights based on searches. 6% potential increase in price ($43 potential increase over avg. RT price).
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Cheapest flight prices on average. 6% potential price decrease ($34 potential savings vs. average RT price).
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Average for round-trip flights in September 2025
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Find flight deals from Panama to Greenville

Cheapest flights from Panama to Greenville
Explore the most affordable flight options available from Panama to Greenville. Find the lowest fares from popular airlines and budget airlines, with prices last updated on September 16, 2025.

This American Airlines deal was found by Cheapflights users on 9/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/313:15 pmPTY - GSP
2 stops20h 49mAmerican Airlines
Fri 11/76:47 pmGSP - PTY
2 stops19h 02mAmerican Airlines
Deal found 9/16$527
This Delta deal was found by Cheapflights users on 9/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/312:21 pmPTY - GSP
1 stop6h 57mDelta
Fri 11/76:35 amGSP - PTY
1 stop7h 21mDelta
Deal found 9/16$644
This American Airlines deal was found by Cheapflights users on 9/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/184:56 pmPTY - GSP
1 stop7h 31mAmerican Airlines
Sat 12/206:26 pmGSP - PTY
2 stops19h 27mAmerican Airlines
Deal found 9/16$665
This Kiwi.com deal was found by Cheapflights users on 9/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/302:55 amPTY - GSP
2 stops15h 28mMultiple Airlines
Fri 11/78:03 pmGSP - PTY
1 stop14h 30mMultiple Airlines
Deal found 9/16$995

Cheapflights Fare Finder

 
Customize your flight search to find flights from Panama to Greenville that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated September 16, 2025.
Use the filters below to find and compare flights from Panama to Greenville that are best for you.

Fly from

Panama

Fly to

Greenville

Route

Depart

Return

Price

Panama CityGreenville

PTY - GSP

PTYGSP

Panama City Tocumen Intl

Fri 10/31

3:15 pm-1:04 pm

2 stops20h 49m

Greenville

Fri 11/7

6:47 pm-1:49 pm

2 stops19h 02m

$527

Panama CityGreenville

PTY - GSP

PTYGSP

Panama City Tocumen Intl

Fri 10/31

2:21 pm-10:18 pm

1 stop6h 57m

Greenville

Fri 11/7

6:35 am-1:56 pm

1 stop7h 21m

$644

Panama CityGreenville

PTY - GSP

PTYGSP

Panama City Tocumen Intl

Thu 12/18

4:56 pm-12:27 am

1 stop7h 31m

Greenville

Sat 12/20

6:26 pm-1:53 pm

2 stops19h 27m

$665

Panama CityGreenville

PTY - GSP

PTYGSP

Panama City Tocumen Intl

Thu 10/30

2:55 am-7:23 pm

2 stops15h 28m

Greenville

Fri 11/7

8:03 pm-10:33 am

1 stop14h 30m

$995

Panama CityGreenville

PTY - GSP

PTYGSP

Panama City Tocumen Intl

Tue 10/7

2:21 pm-11:55 pm

1 stop8h 34m

$311

Panama CityGreenville

PTY - GSP

PTYGSP

Panama City Tocumen Intl

Tue 10/7

3:15 pm-1:03 pm

2 stops20h 48m

$320

Panama CityGreenville

PTY - GSP

PTYGSP

Panama City Tocumen Intl

Fri 9/26

3:31 pm-11:46 am

2 stops19h 15m

$346

Panama CityGreenville

PTY - GSP

PTYGSP

Panama City Tocumen Intl

Fri 9/26

10:00 am-10:39 pm

1 stop11h 39m

$357

Panama CityGreenville

PTY - GSP

PTYGSP

Panama City Tocumen Intl

Tue 10/7

6:34 pm-8:44 pm

3 stops49h 10m

$376

Flights are sorted by cheapest round-trip flights first.

Deals found on 9/15

Best time to book a flight from Panama to Greenville

Have a flexible travel schedule? Discover the best time to fly to Greenville from Panama with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Panama to Greenville

What is the cheapest month to book a flight from Panama to Greenville?

Currently, August is the cheapest month in which you can book a flight from Panama to Greenville (average of $321). Flying from Panama to Greenville in March is currently the most expensive (average of $386). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

Related info for your journey

Find useful and relevant information for your journey from Panama to Greenville. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airport do you fly into for flights to Greenville from Panama?

    For a flight from Panama to Greenville, you will be flying into Greenville. Greenville (GSP) is just 10.4 mi from the center of the city.

  • How long is the flight from Panama to Greenville?

    American Airlines and Delta can get you from Panama to Greenville in just under 6h 57m. Your travel time can differ by up to 13h 52m. Airlines will cover a distance of 1792 mi. This flight may include one or multiple stops.

  • What are the cheapest airlines to fly from Panama to Greenville one-way?

    $311 is the cheapest one-way deal found within the past few days, from Delta. You may also be able to find cheap deals on American Airlines and United Airlines, with prices starting from $320 and $357, respectively.

  • Can I find deals for flights from Panama to Greenville that include hotel bookings?

    Yes. In addition to deals on Panama to Greenville flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Panama to Greenville?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Panama to Greenville.

  • Can I find deals for business class flights from Panama to Greenville?

    Yes. Cheapflights offers flight deals from Panama to Greenville by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Panama to Greenville?

    Currently, August is the cheapest month in which you can book a flight from Panama to Greenville (average of $321). Flying from Panama to Greenville in March is currently the most expensive (average of $386). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Traveling to a place near Greenville?

Book flights to Greenville if you plan to visit one of these locations
Simpsonville
Duncan
Seneca
Anderson

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