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$280+ Cheap flights from Panama to Greenville (GSP)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 5/10. Fares are subject to change and may not be available on all flights or dates of travel.
PTY — GSP
Mar 11 — Mar 181
Wed 3/11
Wed 3/18
1 adult, Economy
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Cheap flight deals from Panama to Greenville

Cheapest flights from Panama to Greenville
Explore the most affordable flight options available from Panama to Greenville. Find the lowest fares from popular airlines and budget airlines, with prices last updated on February 9, 2026.

This American Airlines deal was found by Cheapflights users on 2/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 3/52:40 pm
PTY
-
GSP
2 stops19h 35m
American Airlines
Sun 3/88:17 pm
GSP
-
PTY
2 stops19h 03m
American Airlines
Deal found 2/7$545
This American Airlines deal was found by Cheapflights users on 2/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 2/92:27 pm
PTY
-
GSP
2 stops20h 03m
American Airlines
Mon 2/237:37 pm
GSP
-
PTY
2 stops18h 03m
American Airlines
Deal found 2/6$558
This United Airlines deal was found by Cheapflights users on 2/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 5/283:30 pm
PTY
-
GSP
1 stop29h 41m
United Airlines
Mon 6/14:55 pm
GSP
-
PTY
1 stop24h 17m
United Airlines
Deal found 2/8$565
This American Airlines deal was found by Cheapflights users on 2/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 2/112:27 pm
PTY
-
GSP
2 stops21h 47m
American Airlines
Wed 3/48:21 pm
GSP
-
PTY
2 stops18h 54m
American Airlines
Deal found 2/8$567
This United Airlines deal was found by Cheapflights users on 2/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 2/94:41 pm
PTY
-
GSP
1 stop22h 54m
United Airlines
Wed 3/46:50 am
GSP
-
PTY
1 stop10h 17m
United Airlines
Deal found 2/8$599
This KAYAK deal was found by Cheapflights users on 2/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure KAYAK is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 2/113:20 pm
PTY
-
GSP
1 stop8h 30m
LATAM Airlines
Wed 3/45:40 am
GSP
-
PTY
1 stop8h 10m
LATAM Airlines
Deal found 2/8$608
This American Airlines deal was found by Cheapflights users on 2/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 2/102:27 pm
PTY
-
GSP
1 stop9h 30m
American Airlines
Wed 3/45:29 pm
GSP
-
PTY
2 stops20h 11m
American Airlines
Deal found 2/8$609
This American Airlines deal was found by Cheapflights users on 2/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 2/124:05 pm
PTY
-
GSP
2 stops30h 09m
American Airlines
Wed 3/45:29 pm
GSP
-
PTY
2 stops20h 11m
American Airlines
Deal found 2/8$618
This United Airlines deal was found by Cheapflights users on 2/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 2/134:41 pm
PTY
-
GSP
1 stop29h 18m
United Airlines
Wed 3/46:50 am
GSP
-
PTY
1 stop10h 17m
United Airlines
Deal found 2/8$620

Find flight deals from Panama to Greenville

Keep the following information in mind while searching for Panama to Greenville flight deals. Data was last updated February 9, 2026.

Most accurate provider

FlightHub
3 stars

Most trusted provider

FlightHub
3 stars

Round-trip from

$545
(American Airlines)

One-way from

$343
(United Airlines)

Popular in

April

Cheapest in

June

Average price

$500
Provider with most accurate pricing for Panama City Tocumen Intl-Greenville flight deals.
Search Deals
Provider most trusted by Cheapflights users for Panama City Tocumen Intl-Greenville flights.
Search Deals
From Panama to Greenville
Search Deals
One-way flight from Panama to Greenville
Search Deals
Highest demand for flights based on searches. 6% potential increase in price ($41 potential increase over avg. RT price).
Search Deals
Cheapest flight prices on average. 6% potential price decrease ($37 potential savings vs. average RT price).
Search Deals
Average for round-trip flights in February 2026
Search Deals

Cheapflights Fare Finder

 
Customize your flight search to find flights from Panama to Greenville that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated February 9, 2026.
Use the filters below to find and compare flights from Panama to Greenville that are best for you.

Fly from

Panama

Fly to

Greenville

Route

Depart

Return

Price

Panama CityGreenville

PTY - GSP

PTYGSP

Panama City Tocumen Intl

Thu 3/5

2:40 pm-10:15 am

2 stops19h 35m

Greenville

Sun 3/8

8:17 pm-2:20 pm

2 stops19h 03m

$545

Panama CityGreenville

PTY - GSP

PTYGSP

Panama City Tocumen Intl

Thu 5/28

10:00 am-10:11 pm

1 stop11h 11m

Greenville

Mon 6/1

4:55 pm-2:14 pm

1 stop22h 19m

$565

Panama CityGreenville

PTY - GSP

PTYGSP

Panama City Tocumen Intl

Sun 5/10

1:49 pm-6:15 pm

1 stop27h 26m

$280

Flights are sorted by cheapest round-trip flights first.

Deals found on 2/6

Best time to book a flight from Panama to Greenville

Have a flexible travel schedule? Discover the best time to fly to Greenville from Panama with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Panama to Greenville

What is the cheapest month to book a flight from Panama to Greenville?

Currently, June is the cheapest month in which you can book a flight from Panama to Greenville (average of $209). Flying from Panama to Greenville in February is currently the most expensive (average of $500). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

Related info for your journey

Find useful and relevant information for your journey from Panama to Greenville. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airport do you fly into for flights to Greenville from Panama?

    For a flight from Panama to Greenville, you will be flying into Greenville. Greenville (GSP) is just 10.4 mi from the center of the city.

  • How long is the flight from Panama to Greenville?

    American Airlines and United Airlines can get you from Panama to Greenville in just under 11h 11m. Your travel time can differ by up to 8h 24m. Airlines will cover a distance of 1792 mi. This flight may include one or multiple stops.

  • Can I find deals for flights from Panama to Greenville that include hotel bookings?

    Yes. In addition to deals on Panama to Greenville flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Panama to Greenville?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Panama to Greenville.

  • Can I find deals for business class flights from Panama to Greenville?

    Yes. Cheapflights offers flight deals from Panama to Greenville by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Panama to Greenville?

    Currently, June is the cheapest month in which you can book a flight from Panama to Greenville (average of $209). Flying from Panama to Greenville in February is currently the most expensive (average of $500). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Traveling to a place near Greenville?

Book flights to Greenville if you plan to visit one of these locations
Simpsonville
Duncan
Greer
Seneca
Anderson

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