How long is the flight from Panama to Greenville?

American Airlines can get you from Panama to Greenville in just under 20h 43m. Your travel time can differ by up to . Airlines will cover a distance of 1792 mi.

In terms of precipitation, rainfall in Greenville ranges from 3.6 - 5.1 inches per month. March is typically the wettest month, when rainfall can reach 5.1 in. November is typically the driest time to visit Greenville when rainfall is around 3.6 in.

If weather is an important factor for your trip to Greenville, use this chart to help with planning. For those seeking warmer temperatures, July is the ideal time of year to visit, when temperatures reach an average of 78.8 F. Travelers looking to avoid the cold should look outside of January, when temperatures are typically at their lowest (around 41.0 F).

What is the cheapest time of day to fly from PA to GSP?

Regardless of the time of day you decide to fly, the ticket price will remain around the same. Book flights from Panama to Greenville as you normally would.

What airport do you fly into for flights to Greenville from Panama?

For a flight from Panama to Greenville, you will be flying into Greenville. Greenville (GSP) is just 10.4 mi from the center of the city.

Can I find deals for flights from Panama to Greenville that include hotel bookings?

Yes. In addition to deals on Panama to Greenville flights, Cheapflights offers vacation packages that include both flights and hotel.

How can I find direct flights from Panama to Greenville?

After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Panama to Greenville.

Can I find deals for business class flights from Panama to Greenville?

Yes. Cheapflights offers flight deals from Panama to Greenville by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

$602+ Flights from Panama to Greenville

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Cheap flight deals from Panama to Greenville

Most accurate provider	eDreams 3 stars
Most trusted provider	eDreams 3 stars
Round-trip from	$602 (American Airlines)
Popular in	December
Cheapest in	June
Average price	$478

Provider with most accurate pricing for Panama City Tocumen Intl-Greenville flight deals.

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Provider most trusted by Cheapflights users for Panama City Tocumen Intl-Greenville flights.

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From Panama to Greenville

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Highest demand for flights based on searches. 6% potential increase in price ($43 potential increase over avg. RT price).

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Cheapest flight prices on average. 6% potential price decrease ($34 potential savings vs. average RT price).

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Average for round-trip flights in November 2025

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Find flight deals from Panama to Greenville

Cheapest flights from Panama to Greenville
Explore the most affordable flight options available from Panama to Greenville. Find the lowest fares from popular airlines and budget airlines, with prices last updated on November 3, 2025.

Mon 12/12:43 pmPTY - GSP

2 stops18h 56mAmerican Airlines

Fri 12/126:01 amGSP - PTY

2 stops9h 41mAmerican Airlines

Deal found 11/2

$602

Sun 11/302:55 amPTY - GSP

2 stops16h 28mMultiple Airlines

Fri 12/123:00 pmGSP - PTY

1 stop29h 19mMultiple Airlines

Deal found 11/2

$764

Best flights from Panama to Greenville
Discover carefully curated flight deals from Panama to Greenville that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated November 3, 2025.

Mon 12/12:43 pmPTY - GSP

2 stops20h 43mAmerican Airlines

Fri 12/125:10 amGSP - PTY

1 stop10h 32mAmerican Airlines

Deal found 11/2

$602

Sun 11/302:55 amPTY - GSP

2 stops16h 28mMultiple Airlines

Fri 12/123:00 pmGSP - PTY

1 stop29h 19mMultiple Airlines

Deal found 11/2

$764

Last-minute flights from Panama to Greenville
Discover last-minute flight deals from Panama to Greenville. Data last updated November 3, 2025 and is based on user searches.

Sun 11/302:55 amPTY - GSP

2 stops16h 28mMultiple Airlines

Fri 12/123:00 pmGSP - PTY

1 stop29h 19mMultiple Airlines

Deal found 11/2

$764

Fly from

Fly to

Route

Depart

Return

Price

Panama CityGreenville

PTY - GSP

PTYGSP

Panama City Tocumen Intl

Mon 12/1

2:43 pm-11:26 am

2 stops20h 43m

Greenville

Fri 12/12

5:10 am-3:42 pm

1 stop10h 32m

$602

Panama CityGreenville

PTY - GSP

PTYGSP

Panama City Tocumen Intl

Sun 11/30

2:55 am-7:23 pm

2 stops16h 28m

Greenville

Fri 12/12

3:00 pm-8:19 pm

1 stop29h 19m

$764

Flights are sorted by cheapest round-trip flights first.

Deals found on 11/2

Best time to book a flight from Panama to Greenville

Have a flexible travel schedule? Discover the best time to fly to Greenville from Panama with our price prediction graph.

Estimated round-trip price

Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Panama to Greenville

What is the cheapest month to book a flight from Panama to Greenville?

Currently, November is the cheapest month in which you can book a flight from Panama to Greenville (average of $205). Flying from Panama to Greenville in February is currently the most expensive (average of $467). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

Related info for your journey

What airport do you fly into for flights to Greenville from Panama?
For a flight from Panama to Greenville, you will be flying into Greenville. Greenville (GSP) is just 10.4 mi from the center of the city.
How long is the flight from Panama to Greenville?
American Airlines can get you from Panama to Greenville in just under 20h 43m. Your travel time can differ by up to . Airlines will cover a distance of 1792 mi.
Can I find deals for flights from Panama to Greenville that include hotel bookings?
Yes. In addition to deals on Panama to Greenville flights, Cheapflights offers vacation packages that include both flights and hotel.
How can I find direct flights from Panama to Greenville?
After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Panama to Greenville.
Can I find deals for business class flights from Panama to Greenville?
Yes. Cheapflights offers flight deals from Panama to Greenville by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.
What is the cheapest month to book a flight from Panama to Greenville?
Currently, November is the cheapest month in which you can book a flight from Panama to Greenville (average of $205). Flying from Panama to Greenville in February is currently the most expensive (average of $467). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

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$602+ Cheap flights from Panama to Greenville (GSP)

This is the cheapest round-trip flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 12/1. Fares are subject to change and may not be available on all flights or dates of travel.

Find cheap flights from Panama to Greenville with Cheapflights

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Cheap flight deals from Panama to Greenville

Keep the following information in mind while searching for Panama to Greenville flight deals. Data was last updated November 3, 2025.

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Most trusted provider

Round-trip from

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Cheapest in

Average price

Find flight deals from Panama to Greenville

Cheapest flights from Panama to GreenvilleExplore the most affordable flight options available from Panama to Greenville. Find the lowest fares from popular airlines and budget airlines, with prices last updated on November 3, 2025.

Explore the most affordable flight options available from Panama to Greenville. Find the lowest fares from popular airlines and budget airlines, with prices last updated on November 3, 2025.

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Use the filters below to find and compare flights from Panama to Greenville that are best for you.

Best time to book a flight from Panama to Greenville

Have a flexible travel schedule? Discover the best time to fly to Greenville from Panama with our price prediction graph.

Cheapflights Insights

Everything you need to know about your flight from Panama to Greenville

What is the cheapest month to book a flight from Panama to Greenville?

Related info for your journey

Find useful and relevant information for your journey from Panama to Greenville. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

What airport do you fly into for flights to Greenville from Panama?

How long is the flight from Panama to Greenville?

Can I find deals for flights from Panama to Greenville that include hotel bookings?

How can I find direct flights from Panama to Greenville?

Can I find deals for business class flights from Panama to Greenville?

What is the cheapest month to book a flight from Panama to Greenville?

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Cheapest flights from Panama to Greenville
Explore the most affordable flight options available from Panama to Greenville. Find the lowest fares from popular airlines and budget airlines, with prices last updated on November 3, 2025.