How long is the flight from Louisville to Greenville?

For as low as $269, American Airlines can have you in Greenville from Louisville in 4h 03m. The distance between Louisville and Greenville is about 299 mi. When browsing for deals, the options you’ll see will be for both nonstop flights and flights with stops.

What are the cheapest airlines flying from Louisville to Greenville round-trip?

Flying on American Airlines is currently your cheapest option to Greenville, with prices starting at $190. Another option worth looking into is Delta, starting at $196 round trip. American Airlines is 51% cheaper than the average price of flights available within the next 90 days to this destination.

In terms of precipitation, rainfall in Greenville ranges from 3.6 - 5.1 inches per month. March is typically the wettest month, when rainfall can reach 5.1 in. November is typically the driest time to visit Greenville when rainfall is around 3.6 in.

If weather is an important factor for your trip to Greenville, use this chart to help with planning. For those seeking warmer temperatures, July is the ideal time of year to visit, when temperatures reach an average of 78.8 F. Travelers looking to avoid the cold should look outside of January, when temperatures are typically at their lowest (around 41.0 F).

What is the cheapest time of day to fly from SDF to GSP?

Regardless of the time of day you decide to fly, the ticket price will remain around the same. Book flights from Louisville to Greenville as you normally would.

Most accurate provider : When it comes to deals on Louisville-Greenville flights, users find the pricing of eDreams to be most consistent on Cheapflights vs. eDreams Users can find the same prices on Louisville-Greenville flight deals on Cheapflights vs. eDreams >95% of the time. Price accuracy is based on data collected from Louisville-Greenville flight searches over the past month and is updated monthly.

Most trusted provider : When it comes to deals on Louisville-Greenville flights, Cheapflights users trust eDreams the most. eDreams has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for Louisville-Greenville flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.

Can I find deals for flights from Louisville to Greenville that include hotel bookings?

Yes. In addition to deals on Louisville to Greenville flights, Cheapflights offers vacation packages that include both flights and hotel.

How can I find direct flights from Louisville to Greenville?

After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Louisville to Greenville.

Can I find deals for business class flights from Louisville to Greenville?

Yes. Cheapflights offers flight deals from Louisville to Greenville by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

$243+ Flights from Louisville to Greenville

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1. Tell us where you want to go

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Cheap flight deals from Louisville to Greenville

Cheapest flights from Louisville to Greenville
Explore the most affordable flight options available from Louisville to Greenville. Find the lowest fares from popular airlines and budget airlines, with prices last updated on December 21, 2025.

Sun 12/285:05 amSDF - GSP

2 stops16h 09mMultiple Airlines

Tue 12/309:53 pmGSP - SDF

1 stop10h 31mMultiple Airlines

Deal found 12/19

$458

Sun 12/286:06 pmSDF - GSP

1 stop4h 00mDelta

Tue 12/305:45 amGSP - SDF

1 stop3h 44mDelta

Deal found 12/19

$557

Sun 12/285:05 amSDF - GSP

2 stops14h 35mSouthwest

Tue 12/3010:40 amGSP - SDF

2 stops11h 10mSouthwest

Deal found 12/19

$608

Fri 12/266:27 amSDF - GSP

1 stop4h 34mAmerican Airlines

Tue 12/306:00 amGSP - SDF

1 stop7h 30mAmerican Airlines

Deal found 12/20

$745

Fri 12/265:40 amSDF - GSP

1 stop5h 16mUnited Airlines

Mon 12/296:23 amGSP - SDF

2 stops11h 05mUnited Airlines

Deal found 12/20

$972

Fri 12/265:40 amSDF - GSP

1 stop5h 16mUnited Airlines

Tue 12/305:36 pmGSP - SDF

2 stops21h 08mUnited Airlines

Deal found 12/20

$1,012

Best flights from Louisville to Greenville
Discover carefully curated flight deals from Louisville to Greenville that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated December 21, 2025.

Sat 1/177:11 pmSDF - GSP

1 stop4h 40mAmerican Airlines

Sat 1/247:50 amGSP - SDF

1 stop4h 36mAmerican Airlines

Deal found 12/20

$243

Sat 1/175:35 amSDF - GSP

1 stop4h 41mUnited Airlines

Sat 1/2410:00 amGSP - SDF

1 stop4h 48mUnited Airlines

Deal found 12/20

$243

Tue 1/136:21 pmSDF - GSP

1 stop4h 03mDelta

Thu 1/155:40 amGSP - SDF

1 stop3h 48mDelta

Deal found 12/21

$269

Tue 1/136:00 amSDF - GSP

1 stop5h 25mAmerican Airlines

Thu 1/1512:09 pmGSP - SDF

1 stop6h 21mAmerican Airlines

Deal found 12/19

$269

Sat 2/145:35 amSDF - GSP

1 stop4h 26mUnited Airlines

Wed 2/1810:00 amGSP - SDF

1 stop4h 47mUnited Airlines

Deal found 12/20

$315

Mon 6/12:59 pmSDF - GSP

1 stop5h 18mDelta

Sat 6/66:45 amGSP - SDF

1 stop3h 07mDelta

Deal found 12/19

$327

Last-minute flights from Louisville to Greenville
Discover last-minute flight deals from Louisville to Greenville. Data last updated December 21, 2025 and is based on user searches.

Sun 12/285:05 amSDF - GSP

2 stops16h 09mMultiple Airlines

Tue 12/309:53 pmGSP - SDF

1 stop10h 31mMultiple Airlines

Deal found 12/19

$458

Sat 1/35:40 amSDF - GSP

1 stop5h 16mUnited Airlines

Sat 1/35:36 pmGSP - SDF

1 stop4h 54mUnited Airlines

Deal found 12/20

$431

Thu 1/85:35 amSDF - GSP

1 stop4h 41mUnited Airlines

Thu 1/82:55 pmGSP - SDF

1 stop4h 48mUnited Airlines

Deal found 12/20

$426

Mon 1/1211:10 amSDF - GSP

1 stop5h 42mUnited Airlines

Thu 1/1510:00 amGSP - SDF

1 stop4h 48mUnited Airlines

Deal found 12/18

$341

Tue 1/136:00 amSDF - GSP

1 stop5h 25mAmerican Airlines

Thu 1/1512:09 pmGSP - SDF

1 stop6h 21mAmerican Airlines

Deal found 12/19

$269

Sat 1/175:35 amSDF - GSP

1 stop4h 41mUnited Airlines

Sat 1/2410:00 amGSP - SDF

1 stop4h 48mUnited Airlines

Deal found 12/20

$243

Sat 1/175:26 pmSDF - GSP

2 stops6h 25mAmerican Airlines

Sat 1/2410:32 amGSP - SDF

1 stop5h 20mAmerican Airlines

Deal found 12/20

$248

One-way flights from Louisville to Greenville
Search for one-way flight options from Louisville to Greenville. Find affordable one-way fares based on user searches. Data last updated December 21, 2025.

Wed 12/246:27 amSDF - GSP

1 stop4h 59mAmerican Airlines

Deal found 12/20

$257

Wed 12/246:45 amSDF - GSP

2 stops9h 20mSouthwest

Deal found 12/20

$262

Sun 12/287:24 pmSDF - GSP

1 stop4h 34mAmerican Airlines

Deal found 12/20

$279

Sun 12/285:05 amSDF - GSP

2 stops14h 35mSouthwest

Deal found 12/20

$299

Fri 12/268:00 amSDF - GSP

1 stop6h 03mAmerican Airlines

Deal found 12/20

$359

Fri 12/261:30 pmSDF - GSP

2 stops8h 25mSouthwest

Deal found 12/20

$364

Wed 12/249:14 amSDF - GSP

3 stops28h 12mMultiple Airlines

Deal found 12/20

$404

Sun 12/285:05 amSDF - GSP

3 stops33h 35mMultiple Airlines

Deal found 12/20

$425

Fri 12/265:05 amSDF - GSP

3 stops33h 35mMultiple Airlines

Deal found 12/20

$591

Find flight deals from Louisville to Greenville

Most accurate provider	eDreams 3 stars
Most trusted provider	eDreams 3 stars
Round-trip from	$243 (American Airlines)
Popular in	February
Cheapest in	September
Average price	$474

Provider with most accurate pricing for Louisville Intl-Greenville flight deals.

Search Deals

Provider most trusted by Cheapflights users for Louisville Intl-Greenville flights.

Search Deals

From Louisville Intl to Greenville

Search Deals

Highest demand for flights based on searches. 19% potential increase in price ($95 potential increase over avg. RT price).

Search Deals

Cheapest flight prices on average. 4% potential price decrease ($18 potential savings vs. average RT price).

Search Deals

Average for round-trip flights in December 2025

Search Deals

Cheapflights Fare Finder

Use the filters below to find and compare flights from Louisville to Greenville that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

LouisvilleGreenville

SDF - GSP

SDFGSP

Louisville Intl

Sat 1/17

7:11 pm-11:51 pm

1 stop4h 40m

Greenville

Sat 1/24

7:50 am-12:26 pm

1 stop4h 36m

$243

LouisvilleGreenville

SDF - GSP

SDFGSP

Louisville Intl

Sat 1/17

5:35 am-10:16 am

1 stop4h 41m

Greenville

Sat 1/24

10:00 am-2:48 pm

1 stop4h 48m

$243

LouisvilleGreenville

SDF - GSP

SDFGSP

Louisville Intl

Tue 1/13

6:21 pm-10:24 pm

1 stop4h 03m

Greenville

Thu 1/15

5:40 am-9:28 am

1 stop3h 48m

$269

LouisvilleGreenville

SDF - GSP

SDFGSP

Louisville Intl

Tue 1/13

6:00 am-11:25 am

1 stop5h 25m

Greenville

Thu 1/15

12:09 pm-6:30 pm

1 stop6h 21m

$269

LouisvilleGreenville

SDF - GSP

SDFGSP

Louisville Intl

Sat 2/14

5:35 am-10:01 am

1 stop4h 26m

Greenville

Wed 2/18

10:00 am-2:47 pm

1 stop4h 47m

$315

LouisvilleGreenville

SDF - GSP

SDFGSP

Louisville Intl

Mon 6/1

2:59 pm-8:17 pm

1 stop5h 18m

Greenville

Sat 6/6

6:45 am-9:52 am

1 stop3h 07m

$327

LouisvilleGreenville

SDF - GSP

SDFGSP

Louisville Intl

Sun 12/28

7:24 pm-11:58 pm

1 stop4h 34m

$279

LouisvilleGreenville

SDF - GSP

SDFGSP

Louisville Intl

Sun 12/28

5:05 am-7:40 pm

2 stops14h 35m

$299

LouisvilleGreenville

SDF - GSP

SDFGSP

Louisville Intl

Fri 12/26

8:00 am-2:03 pm

1 stop6h 03m

$359

LouisvilleGreenville

SDF - GSP

SDFGSP

Louisville Intl

Fri 12/26

1:30 pm-9:55 pm

2 stops8h 25m

$364

Flights are sorted by cheapest round-trip flights first.

Deals found on 12/20

Showing 1-10 of 12 results

Compare providers for flights from Louisville to Greenville

Use the table below to compare price accuracy, trust ratings, and cancellation policies for each provider offering flight deals from Louisville to Greenville in December.

Provider	Price Accuracy	Trust Score*
Expedia	Price Accuracy2 stars	Trust Score*3 stars
eDreams	Price Accuracy3 stars	Trust Score*3 stars
FlightHub	Price Accuracy3 stars	Trust Score*1 star

*The Trust Score is based on feedback from users after their booking experience. It measures overall satisfaction, helping us identify issues like hidden fees, problems during the ticketing process, and the quality of customer service. This score is our best indicator of the provider's quality and reliability.

Most accurate provider: When it comes to deals on Louisville-Greenville flights, users find the pricing of eDreams to be most consistent on Cheapflights vs. eDreams Users can find the same prices on Louisville-Greenville flight deals on Cheapflights vs. eDreams >95% of the time. Price accuracy is based on data collected from Louisville-Greenville flight searches over the past month and is updated monthly.
Most trusted provider: When it comes to deals on Louisville-Greenville flights, Cheapflights users trust eDreams the most. eDreams has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for Louisville-Greenville flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.

Best time to book a flight from Louisville to Greenville

Have a flexible travel schedule? Discover the best time to fly to Greenville from Louisville with our price prediction graph.

Estimated round-trip price

Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Louisville to Greenville

What is the cheapest month to book a flight from Louisville to Greenville?

Currently, September is the cheapest month in which you can book a flight from Louisville to Greenville (average of $128). Flying from Louisville to Greenville in January is currently the most expensive (average of $215). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

Reviews of airlines servicing Greenville

Read reviews from past customers who have flown Delta and American Airlines from Louisville to Greenville. Users can see the overall rating for each airline as well as how each is rated in terms of entertainment options, comfort, food, crew/service, and boarding process.

Delta

7.9

Good

8,021 reviews

Reviews

1 / 20

6.0

Good

Jim,Nov 2025

AVL - ATL

The exit row seats without a seat in front are great for leg room but don’t have a fold out entertainment console so you’re forced to use the screen several feet in front of you (there is, at least, a remote). Best to bring a tablet loaded with entertainment or a book.

Delta

7.9

Good

8,021 reviews

Delta

7.9

Good

8,021 reviews

Reviews

1 / 20

6.0

Good

Jim,Nov 2025

AVL - ATL

American Airlines

7.2

Good

11,050 reviews

Delta

7.9

Good

8,021 reviews

Reviews

1 / 20

6.0

Good

Jim,Nov 2025

AVL - ATL

Related info for your journey

How long is the flight from Louisville to Greenville?
For as low as $269, American Airlines can have you in Greenville from Louisville in 4h 03m. The distance between Louisville and Greenville is about 299 mi. When browsing for deals, the options you’ll see will be for both nonstop flights and flights with stops.
What are the cheapest airlines flying from Louisville to Greenville round-trip?
Flying on American Airlines is currently your cheapest option to Greenville, with prices starting at $190. Another option worth looking into is Delta, starting at $196 round trip. American Airlines is 51% cheaper than the average price of flights available within the next 90 days to this destination.
Can I find deals for flights from Louisville to Greenville that include hotel bookings?
Yes. In addition to deals on Louisville to Greenville flights, Cheapflights offers vacation packages that include both flights and hotel.
How can I find direct flights from Louisville to Greenville?
After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Louisville to Greenville.
Can I find deals for business class flights from Louisville to Greenville?
Yes. Cheapflights offers flight deals from Louisville to Greenville by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.
What is the cheapest month to book a flight from Louisville to Greenville?
Currently, September is the cheapest month in which you can book a flight from Louisville to Greenville (average of $128). Flying from Louisville to Greenville in January is currently the most expensive (average of $215). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Simpsonville

Duncan

Greer

Seneca

Anderson

Browse thousands of different options on Cheapflights for your next trip

Top 2 airlines flying from Louisville to Greenville

Airline	Cheapest	Average	Flexibility	On-time
American Airlines	Cheapest$190	Average$291	FlexibilityNo cancel fee	On-time71%
Delta	Cheapest$196	Average$306	FlexibilityNo cancel fee	On-timeN/A

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$243+ Cheap flights from Louisville to Greenville (SDF - GSP)

This is the cheapest round-trip flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 1/17. Fares are subject to change and may not be available on all flights or dates of travel.

Find cheap flights from Louisville to Greenville with Cheapflights

1. Tell us where you want to go

2. Select your favorite providers

3. Compare prices and book

Cheap flight deals from Louisville to Greenville

Cheapest flights from Louisville to GreenvilleExplore the most affordable flight options available from Louisville to Greenville. Find the lowest fares from popular airlines and budget airlines, with prices last updated on December 21, 2025.

Explore the most affordable flight options available from Louisville to Greenville. Find the lowest fares from popular airlines and budget airlines, with prices last updated on December 21, 2025.

Find flight deals from Louisville to Greenville

Most accurate provider

Most trusted provider

Round-trip from

Popular in

Cheapest in

Average price

Cheapflights Fare Finder

Use the filters below to find and compare flights from Louisville to Greenville that are best for you.

Compare providers for flights from Louisville to Greenville

Provider information is updated monthly. Please note that these providers often have deals for this flight, but the availability may vary on a day-by-day basis on Cheapflights.

Use the table below to compare price accuracy, trust ratings, and cancellation policies for each provider offering flight deals from Louisville to Greenville in December.

Best time to book a flight from Louisville to Greenville

Have a flexible travel schedule? Discover the best time to fly to Greenville from Louisville with our price prediction graph.

Cheapflights Insights

Everything you need to know about your flight from Louisville to Greenville

What is the cheapest month to book a flight from Louisville to Greenville?

Reviews of airlines servicing Greenville

Read reviews from past customers who have flown Delta and American Airlines from Louisville to Greenville. Users can see the overall rating for each airline as well as how each is rated in terms of entertainment options, comfort, food, crew/service, and boarding process.

Related info for your journey

Find useful and relevant information for your journey from Louisville to Greenville. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

How long is the flight from Louisville to Greenville?

What are the cheapest airlines flying from Louisville to Greenville round-trip?

Can I find deals for flights from Louisville to Greenville that include hotel bookings?

How can I find direct flights from Louisville to Greenville?

Can I find deals for business class flights from Louisville to Greenville?

What is the cheapest month to book a flight from Louisville to Greenville?

Traveling to a place near Greenville?

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Alternative routes for Louisville to Greenville

See prices for flight routes from nearby airports that may be better suited for you.

Top 2 airlines flying from Louisville to Greenville

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Cheapest flights from Louisville to Greenville
Explore the most affordable flight options available from Louisville to Greenville. Find the lowest fares from popular airlines and budget airlines, with prices last updated on December 21, 2025.