$357+ Cheap flights from Knoxville to Gainesville (TYS - GNV)
This is the cheapest round-trip flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 10/7. Fares are subject to change and may not be available on all flights or dates of travel.
TYS — GNV
Oct 9 — Oct 161
Round-trip
1 adult, Economy
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Find cheap flights from Knoxville to Gainesville with Cheapflights
1. Tell us where you want to go
Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”2. Select your favorite providers
We find the providers serving your travel needs. Choose up to four travel providers to compare side-by-side for flights, hotels, or car rentals.3. Compare prices and book
Review each provider’s pricing and select the best option for you! Book through your favorite provider’s website for a seamless experience.Cheap flight deals from Knoxville to Gainesville
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One-way
Cheapest flights from Knoxville to GainesvilleExplore the most affordable flight options available from Knoxville to Gainesville. Find the lowest fares from popular airlines and budget airlines, with prices last updated on September 9, 2026.
Explore the most affordable flight options available from Knoxville to Gainesville. Find the lowest fares from popular airlines and budget airlines, with prices last updated on September 9, 2026.
This American Airlines deal was found by Cheapflights users on 9/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/74:49 pm -
1 stop5h 37m
Wed 10/147:34 pm -
1 stop4h 21m
Deal found 9/6![American Airlines logo]()
$357
This Delta deal was found by Cheapflights users on 9/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/85:40 am -
1 stop3h 54m
Mon 10/127:03 pm -
1 stop4h 56m
Deal found 9/4![Delta logo]()
$389
This Delta deal was found by Cheapflights users on 9/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 11/2111:12 am -
1 stop3h 44m
Sun 11/2210:16 am -
1 stop3h 19m
Deal found 9/6![Delta logo]()
$433
This American Airlines deal was found by Cheapflights users on 9/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/163:53 pm -
1 stop5h 57m
Sun 9/207:34 pm -
1 stop4h 17m
Deal found 9/4![American Airlines logo]()
$467
This American Airlines deal was found by Cheapflights users on 9/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 11/211:51 pm -
1 stop3h 33m
Sun 11/225:55 pm -
1 stop3h 46m
Deal found 9/5![American Airlines logo]()
$478
This American Airlines deal was found by Cheapflights users on 9/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 9/1712:09 pm -
1 stop3h 49m
Sat 9/194:39 pm -
1 stop6h 11m
Deal found 9/6![American Airlines logo]()
$527
This American Airlines deal was found by Cheapflights users on 9/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 11/67:16 pm -
1 stop4h 43m
Sun 11/87:34 pm -
1 stop4h 24m
Deal found 9/9![American Airlines logo]()
$537
This American Airlines deal was found by Cheapflights users on 9/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/84:49 pm -
2 stops7h 10m
Mon 10/127:34 pm -
1 stop4h 21m
Deal found 9/4![American Airlines logo]()
$542
Best flights from Knoxville to GainesvilleDiscover carefully curated flight deals from Knoxville to Gainesville that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated September 9, 2026.
Discover carefully curated flight deals from Knoxville to Gainesville that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated September 9, 2026.
This American Airlines deal was found by Cheapflights users on 9/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/74:49 pm -
1 stop5h 37m
Wed 10/147:34 pm -
1 stop4h 21m
Deal found 9/6![American Airlines logo]()
$357
This Delta deal was found by Cheapflights users on 9/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/85:40 am -
1 stop3h 54m
Mon 10/127:03 pm -
1 stop4h 56m
Deal found 9/4![Delta logo]()
$389
This Delta deal was found by Cheapflights users on 9/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 11/135:40 am -
1 stop3h 51m
Sun 11/156:00 am -
1 stop5h 28m
Deal found 9/5![Delta logo]()
$389
This Delta deal was found by Cheapflights users on 9/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 11/2111:12 am -
1 stop3h 44m
Sun 11/2210:16 am -
1 stop3h 19m
Deal found 9/6![Delta logo]()
$433
This American Airlines deal was found by Cheapflights users on 9/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 11/211:51 pm -
1 stop3h 33m
Sun 11/225:55 pm -
1 stop6h 04m
Deal found 9/6![American Airlines logo]()
$478
This American Airlines deal was found by Cheapflights users on 9/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 11/67:16 pm -
1 stop4h 43m
Sun 11/87:34 pm -
1 stop4h 24m
Deal found 9/9![American Airlines logo]()
$537
This American Airlines deal was found by Cheapflights users on 9/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/84:49 pm -
2 stops7h 10m
Mon 10/127:34 pm -
1 stop4h 21m
Deal found 9/4![American Airlines logo]()
$542
This Delta deal was found by Cheapflights users on 9/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/238:55 am -
1 stop6h 11m
Sun 9/276:57 pm -
1 stop4h 58m
Deal found 9/8![Delta logo]()
$589
This American Airlines deal was found by Cheapflights users on 9/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/236:15 am -
1 stop4h 04m
Sun 9/276:00 am -
2 stops9h 16m
Deal found 9/8![American Airlines logo]()
$586
This Delta deal was found by Cheapflights users on 9/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 9/255:40 am -
1 stop3h 51m
Sun 9/276:57 pm -
1 stop4h 58m
Deal found 9/8![Delta logo]()
$631
Last-minute flights from Knoxville to GainesvilleDiscover last-minute flight deals from Knoxville to Gainesville. Data last updated September 9, 2026 and is based on user searches.
Discover last-minute flight deals from Knoxville to Gainesville. Data last updated September 9, 2026 and is based on user searches.
This American Airlines deal was found by Cheapflights users on 9/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 9/1012:09 pm -
1 stop3h 49m
Sun 9/131:46 pm -
1 stop3h 51m
Deal found 9/6![American Airlines logo]()
$582
This American Airlines deal was found by Cheapflights users on 9/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/163:53 pm -
1 stop5h 57m
Sun 9/207:34 pm -
1 stop4h 17m
Deal found 9/4![American Airlines logo]()
$467
This American Airlines deal was found by Cheapflights users on 9/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 9/1712:09 pm -
1 stop3h 49m
Sat 9/194:39 pm -
1 stop6h 11m
Deal found 9/6![American Airlines logo]()
$527
This American Airlines deal was found by Cheapflights users on 9/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/236:15 am -
1 stop4h 04m
Sun 9/276:00 am -
2 stops9h 16m
Deal found 9/8![American Airlines logo]()
$586
This Delta deal was found by Cheapflights users on 9/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/238:55 am -
1 stop6h 11m
Sun 9/276:57 pm -
1 stop4h 58m
Deal found 9/8![Delta logo]()
$589
This American Airlines deal was found by Cheapflights users on 9/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/74:49 pm -
1 stop5h 37m
Wed 10/147:34 pm -
1 stop4h 21m
Deal found 9/6![American Airlines logo]()
$357
This Delta deal was found by Cheapflights users on 9/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/85:40 am -
1 stop3h 54m
Mon 10/127:03 pm -
1 stop4h 56m
Deal found 9/4![Delta logo]()
$389
This American Airlines deal was found by Cheapflights users on 9/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/84:49 pm -
2 stops7h 10m
Mon 10/127:34 pm -
1 stop4h 21m
Deal found 9/4![American Airlines logo]()
$542
One-way flights from Knoxville to GainesvilleSearch for one-way flight options from Knoxville to Gainesville. Find affordable one-way fares based on user searches. Data last updated September 9, 2026.
Search for one-way flight options from Knoxville to Gainesville. Find affordable one-way fares based on user searches. Data last updated September 9, 2026.
This Delta deal was found by Cheapflights users on 9/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 9/205:40 am -
1 stop3h 51m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/7![Delta logo]()
$413
This American Airlines deal was found by Cheapflights users on 9/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 9/207:15 am -
2 stops9h 03m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/7![American Airlines logo]()
$935
Find flight deals from Knoxville to Gainesville
Discover tips and strategies to find the most affordable flight options for your journey from Knoxville (TYS) to Gainesville (GNV). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated September 9, 2026.
Most accurate provider | FlightHub 3 stars |
|---|---|
Most trusted provider | FlightHub 3 stars |
Round-trip from | $357 (American Airlines) |
Cheapflights Fare Finder
Customize your flight search to find flights from Knoxville to Gainesville that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 7,457,451 searches. Data last updated September 9, 2026.
Use the filters below to find and compare flights from Knoxville to Gainesville that are best for you.
Fly from
Fly to
Route
Depart
Return
Cheapest round-trip
KnoxvilleGainesville
TYS Knoxville McGhee Tyson - GNV Gainesville Regional
TYSGNV
Knoxville McGhee Tyson
Wed 10/7
4:49 pm-10:26 pm
1 stop5h 37m
Gainesville Regional
Wed 10/14
7:34 pm-11:55 pm
1 stop4h 21m
$357
KnoxvilleGainesville
TYS Knoxville McGhee Tyson - GNV Gainesville Regional
TYSGNV
Knoxville McGhee Tyson
Thu 10/8
5:40 am-9:34 am
1 stop3h 54m
Gainesville Regional
Mon 10/12
7:03 pm-11:59 pm
1 stop4h 56m
$389
KnoxvilleGainesville
TYS Knoxville McGhee Tyson - GNV Gainesville Regional
TYSGNV
Knoxville McGhee Tyson
Fri 11/13
5:40 am-9:31 am
1 stop3h 51m
Gainesville Regional
Sun 11/15
6:00 am-11:28 am
1 stop5h 28m
$389
Quickest round-trip
KnoxvilleGainesville
TYS Knoxville McGhee Tyson - GNV Gainesville Regional
TYSGNV
Knoxville McGhee Tyson
Sun 9/20
5:40 am-9:31 am
1 stop3h 51m
Gainesville Regional
Wed 12/31
12:00 am-12:00 am
Nonstop0h 00m
$413
KnoxvilleGainesville
TYS Knoxville McGhee Tyson - GNV Gainesville Regional
TYSGNV
Knoxville McGhee Tyson
Sat 11/21
11:12 am-2:56 pm
1 stop3h 44m
Gainesville Regional
Sun 11/22
10:16 am-1:35 pm
1 stop3h 19m
$433
KnoxvilleGainesville
TYS Knoxville McGhee Tyson - GNV Gainesville Regional
TYSGNV
Knoxville McGhee Tyson
Sat 11/21
1:51 pm-5:24 pm
1 stop3h 33m
Gainesville Regional
Sun 11/22
5:55 pm-11:59 pm
1 stop6h 04m
$478
KnoxvilleGainesville
TYS Knoxville McGhee Tyson - GNV Gainesville Regional
TYSGNV
Knoxville McGhee Tyson
Fri 11/6
7:16 pm-11:59 pm
1 stop4h 43m
Gainesville Regional
Sun 11/8
7:34 pm-11:58 pm
1 stop4h 24m
$537
KnoxvilleGainesville
TYS Knoxville McGhee Tyson - GNV Gainesville Regional
TYSGNV
Knoxville McGhee Tyson
Thu 10/8
4:49 pm-11:59 pm
2 stops7h 10m
Gainesville Regional
Mon 10/12
7:34 pm-11:55 pm
1 stop4h 21m
$542
KnoxvilleGainesville
TYS Knoxville McGhee Tyson - GNV Gainesville Regional
TYSGNV
Knoxville McGhee Tyson
Wed 9/23
6:15 am-10:19 am
1 stop4h 04m
Gainesville Regional
Sun 9/27
6:00 am-3:16 pm
2 stops9h 16m
$586
KnoxvilleGainesville
TYS Knoxville McGhee Tyson - GNV Gainesville Regional
TYSGNV
Knoxville McGhee Tyson
Wed 9/23
8:55 am-3:06 pm
1 stop6h 11m
Gainesville Regional
Sun 9/27
6:57 pm-11:55 pm
1 stop4h 58m
$589
Showing 1-10 of 11 resultsSorted by cheapest first
Compare providers for flights from Knoxville to Gainesville
Provider information is updated monthly. Please note that these providers often have deals for this flight, but the availability may vary on a day-by-day basis on Cheapflights.
Use the table below to compare price accuracy, trust ratings, and cancellation policies for each provider offering flight deals from Knoxville to Gainesville in September.
| Provider | Price Accuracy | Trust Score* |
|---|---|---|
| Price Accuracy1 star | Trust Score*3 stars | |
| Price Accuracy3 stars | Trust Score*3 stars |
- Most accurate provider: When it comes to deals on Knoxville-Gainesville flights, users find the pricing of FlightHub to be most consistent on Cheapflights vs. FlightHub Users can find the same prices on Knoxville-Gainesville flight deals on Cheapflights vs. FlightHub >95% of the time. Price accuracy is based on data collected from Knoxville-Gainesville flight searches over the past month and is updated monthly.
- Most trusted provider: When it comes to deals on Knoxville-Gainesville flights, Cheapflights users trust FlightHub the most. FlightHub has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for Knoxville-Gainesville flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.
Best time to book a flight from Knoxville to Gainesville
Have a flexible travel schedule? Discover the best time to fly to Gainesville from Knoxville with our price prediction graph.
TYS-GNV
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.
Related info for your journey
Find useful and relevant information for your journey from Knoxville to Gainesville. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.
Traveling to a place near Gainesville?
Book flights to Gainesville if you plan to visit one of these locationsLake City
Alachua
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