$130+ Cheap flights from Des Moines (DSM) to Florida Keys
This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 7/19. Fares are subject to change and may not be available on all flights or dates of travel.
DSM — EYW
Jun 25 — Jul 21
Round-trip
1 adult, Economy
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Find cheap flights from Des Moines to Florida Keys with Cheapflights
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Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”2. Select your favorite providers
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Cheapest flights from Des Moines to Florida KeysExplore the most affordable flight options available from Des Moines to Florida Keys. Find the lowest fares from popular airlines and budget airlines, with prices last updated on May 26, 2026.
Explore the most affordable flight options available from Des Moines to Florida Keys. Find the lowest fares from popular airlines and budget airlines, with prices last updated on May 26, 2026.
This United Airlines deal was found by Cheapflights users on 5/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 9/241:35 pm
DSM
- MIA
1 stop7h 22m
United Airlines
Mon 9/283:53 pm
MIA
- DSM
1 stop9h 04m
United Airlines
Deal found 5/22![United Airlines logo]()
$267
This United Airlines deal was found by Cheapflights users on 5/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 9/128:00 am
DSM
- MIA
2 stops9h 52m
United Airlines
Wed 9/233:57 pm
MIA
- DSM
1 stop6h 30m
United Airlines
Deal found 5/24![United Airlines logo]()
$272
This Kiwi.com deal was found by Cheapflights users on 5/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 7/44:59 pm
DSM
- EYW
1 stop18h 49m
Allegiant Air
Sat 7/112:44 pm
EYW
- DSM
1 stop7h 59m
Allegiant Air
Deal found 5/21![Allegiant Air logo]()
$279
This American Airlines deal was found by Cheapflights users on 5/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 7/46:02 am
DSM
- EYW
1 stop6h 39m
American Airlines
Wed 7/81:01 pm
EYW
- DSM
1 stop7h 29m
American Airlines
Deal found 5/23![American Airlines logo]()
$289
This Kiwi.com deal was found by Cheapflights users on 5/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 6/204:22 pm
DSM
- EYW
1 stop21h 50m
Allegiant Air
Sat 6/272:48 pm
EYW
- DSM
1 stop9h 04m
Allegiant Air
Deal found 5/26![Allegiant Air logo]()
$302
This United Airlines deal was found by Cheapflights users on 5/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 7/76:00 am
DSM
- MIA
1 stop7h 57m
United Airlines
Tue 7/147:37 am
MIA
- DSM
1 stop9h 38m
United Airlines
Deal found 5/24![United Airlines logo]()
$303
This United Airlines deal was found by Cheapflights users on 5/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/311:45 pm
DSM
- MIA
1 stop7h 06m
United Airlines
Sun 11/87:15 am
MIA
- DSM
1 stop7h 56m
United Airlines
Deal found 5/23![United Airlines logo]()
$307
This American Airlines deal was found by Cheapflights users on 5/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 12/52:08 pm
DSM
- EYW
1 stop6h 37m
American Airlines
Wed 12/98:00 am
EYW
- DSM
1 stop6h 19m
American Airlines
Deal found 5/25![American Airlines logo]()
$309
This Booking.com deal was found by Cheapflights users on 5/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Booking.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 10/192:31 pm
DSM
- MIA
1 stop14h 17m
Frontier
Mon 10/267:20 am
MIA
- DSM
1 stop6h 58m
Frontier
Deal found 5/24![Frontier logo]()
$309
This Kiwi.com deal was found by Cheapflights users on 5/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 8/811:13 am
DSM
- EYW
1 stop25h 18m
Allegiant Air
Thu 8/1310:56 am
EYW
- DSM
2 stops31h 21m
Allegiant Air
Deal found 5/25![Allegiant Air logo]()
$313
This United Airlines deal was found by Cheapflights users on 5/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 9/241:35 pm
DSM
- MIA
1 stop7h 22m
United Airlines
Wed 9/3012:29 pm
MIA
- DSM
1 stop6h 04m
United Airlines
Deal found 5/22![United Airlines logo]()
$313
This American Airlines deal was found by Cheapflights users on 5/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 11/46:00 am
DSM
- EYW
2 stops9h 12m
American Airlines
Sat 11/74:26 pm
EYW
- DSM
1 stop7h 50m
American Airlines
Deal found 5/25![American Airlines logo]()
$314
Best flights from Des Moines to Florida KeysDiscover carefully curated flight deals from Des Moines to Florida Keys that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated May 26, 2026.
Discover carefully curated flight deals from Des Moines to Florida Keys that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated May 26, 2026.
This United Airlines deal was found by Cheapflights users on 5/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 10/263:15 pm
DSM
- MIA
1 stop6h 02m
United Airlines
Thu 10/294:06 pm
MIA
- DSM
1 stop7h 55m
United Airlines
Deal found 5/21![United Airlines logo]()
$267
This American Airlines deal was found by Cheapflights users on 5/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 11/46:00 am
DSM
- EYW
2 stops9h 12m
American Airlines
Sat 11/74:26 pm
EYW
- DSM
1 stop7h 50m
American Airlines
Deal found 5/22![American Airlines logo]()
$314
This Delta deal was found by Cheapflights users on 5/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 6/1611:28 am
DSM
- EYW
1 stop7h 25m
Delta
Wed 6/247:50 am
EYW
- DSM
1 stop6h 45m
Delta
Deal found 5/26![Delta logo]()
$329
This Southwest deal was found by Cheapflights users on 5/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 7/305:10 am
DSM
- MIA
2 stops15h 55m
Southwest
Thu 8/67:15 am
MIA
- DSM
1 stop5h 10m
Southwest
Deal found 5/21![Southwest logo]()
$339
This United Airlines deal was found by Cheapflights users on 5/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 9/128:00 am
DSM
- MIA
2 stops9h 52m
United Airlines
Wed 9/233:57 pm
MIA
- DSM
1 stop6h 30m
United Airlines
Deal found 5/24![United Airlines logo]()
$272
This United Airlines deal was found by Cheapflights users on 5/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 9/241:35 pm
DSM
- MIA
1 stop7h 22m
United Airlines
Wed 9/3012:29 pm
MIA
- DSM
1 stop6h 04m
United Airlines
Deal found 5/22![United Airlines logo]()
$313
This Delta deal was found by Cheapflights users on 5/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 6/1011:28 am
DSM
- EYW
1 stop4h 59m
Delta
Tue 6/166:24 pm
EYW
- DSM
1 stop5h 07m
Delta
Deal found 5/26![Delta logo]()
$358
This United Airlines deal was found by Cheapflights users on 5/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 7/146:00 am
DSM
- MIA
1 stop7h 57m
United Airlines
Mon 7/204:10 pm
MIA
- DSM
1 stop6h 12m
United Airlines
Deal found 5/22![United Airlines logo]()
$357
This American Airlines deal was found by Cheapflights users on 5/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/76:00 am
DSM
- EYW
1 stop6h 42m
American Airlines
Mon 10/125:12 pm
EYW
- DSM
1 stop7h 55m
American Airlines
Deal found 5/24![American Airlines logo]()
$476
This United Airlines deal was found by Cheapflights users on 5/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/316:15 am
DSM
- MIA
2 stops13h 22m
United Airlines
Sun 11/87:15 am
MIA
- DSM
1 stop7h 56m
United Airlines
Deal found 5/23![United Airlines logo]()
$362
This Delta deal was found by Cheapflights users on 5/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 6/2011:40 am
DSM
- EYW
1 stop7h 13m
Delta
Wed 6/247:50 am
EYW
- DSM
1 stop6h 45m
Delta
Deal found 5/26![Delta logo]()
$464
This United Airlines deal was found by Cheapflights users on 5/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/288:00 am
DSM
- MIA
2 stops11h 37m
United Airlines
Tue 11/312:00 pm
MIA
- DSM
1 stop8h 25m
United Airlines
Deal found 5/24![United Airlines logo]()
$362
This United Airlines deal was found by Cheapflights users on 5/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 9/2211:32 am
DSM
- MIA
2 stops11h 20m
United Airlines
Mon 9/283:53 pm
MIA
- DSM
1 stop9h 04m
United Airlines
Deal found 5/24![United Airlines logo]()
$362
This American Airlines deal was found by Cheapflights users on 5/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 7/47:00 am
DSM
- EYW
2 stops11h 23m
American Airlines
Sat 7/111:01 pm
EYW
- DSM
2 stops11h 57m
American Airlines
Deal found 5/21![American Airlines logo]()
$567
Last-minute flights from Des Moines to Florida KeysDiscover last-minute flight deals from Des Moines to Florida Keys. Data last updated May 26, 2026 and is based on user searches.
Discover last-minute flight deals from Des Moines to Florida Keys. Data last updated May 26, 2026 and is based on user searches.
This American Airlines deal was found by Cheapflights users on 5/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 5/295:50 am
DSM
- MIA
Nonstop3h 18m
American Airlines
Wed 6/38:30 pm
MIA
- DSM
Nonstop3h 38m
American Airlines
Deal found 5/22![American Airlines logo]()
$347
This Delta deal was found by Cheapflights users on 5/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 5/296:41 pm
DSM
- MIA
1 stop5h 06m
Delta
Wed 6/312:40 pm
MIA
- DSM
1 stop8h 56m
Delta
Deal found 5/22![Delta logo]()
$367
This Delta deal was found by Cheapflights users on 5/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 6/1011:28 am
DSM
- EYW
1 stop7h 25m
Delta
Tue 6/166:24 pm
EYW
- DSM
1 stop5h 07m
Delta
Deal found 5/25![Delta logo]()
$358
This American Airlines deal was found by Cheapflights users on 5/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 6/105:30 am
DSM
- EYW
2 stops9h 37m
American Airlines
Tue 6/164:17 pm
EYW
- DSM
1 stop9h 18m
American Airlines
Deal found 5/25![American Airlines logo]()
$363
This Kiwi.com deal was found by Cheapflights users on 5/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 6/1710:00 am
DSM
- EYW
1 stop5h 17m
Allegiant Air
Fri 6/194:35 pm
EYW
- DSM
1 stop7h 02m
Allegiant Air
Deal found 5/21![Allegiant Air logo]()
$351
This American Airlines deal was found by Cheapflights users on 5/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 6/186:02 am
DSM
- EYW
2 stops12h 08m
American Airlines
Wed 6/247:29 pm
EYW
- DSM
1 stop5h 43m
American Airlines
Deal found 5/24![American Airlines logo]()
$314
This American Airlines deal was found by Cheapflights users on 5/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 6/196:02 am
DSM
- EYW
2 stops11h 47m
American Airlines
Mon 6/227:29 pm
EYW
- DSM
1 stop5h 43m
American Airlines
Deal found 5/24![American Airlines logo]()
$334
This Kiwi.com deal was found by Cheapflights users on 5/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 6/194:07 pm
DSM
- EYW
1 stop20h 51m
Allegiant Air
Mon 6/223:25 pm
EYW
- DSM
1 stop24h 56m
Allegiant Air
Deal found 5/21![Allegiant Air logo]()
$345
This Kiwi.com deal was found by Cheapflights users on 5/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 6/204:22 pm
DSM
- EYW
1 stop21h 50m
Allegiant Air
Mon 6/223:25 pm
EYW
- DSM
1 stop24h 56m
Allegiant Air
Deal found 5/21![Allegiant Air logo]()
$324
This Booking.com deal was found by Cheapflights users on 5/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Booking.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 6/222:26 pm
DSM
- MIA
1 stop14h 28m
Frontier
Mon 6/296:00 am
MIA
- DSM
1 stop8h 31m
Frontier
Deal found 5/25![Frontier logo]()
$342
This Delta deal was found by Cheapflights users on 5/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 6/266:39 pm
DSM
- MIA
1 stop5h 12m
Delta
Tue 6/306:31 am
MIA
- DSM
1 stop8h 34m
Delta
Deal found 5/24![Delta logo]()
$370
This Kiwi.com deal was found by Cheapflights users on 5/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 6/285:02 pm
DSM
- MIA
1 stop26h 31m
Multiple Airlines
Thu 7/211:19 am
MIA
- DSM
2 stops12h 48m
Multiple Airlines
Deal found 5/23![Multiple Airlines logo]()
$328
One-way flights from Des Moines to Florida KeysSearch for one-way flight options from Des Moines to Florida Keys. Find affordable one-way fares based on user searches. Data last updated May 26, 2026.
Search for one-way flight options from Des Moines to Florida Keys. Find affordable one-way fares based on user searches. Data last updated May 26, 2026.
This Kiwi.com deal was found by Cheapflights users on 5/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 7/193:59 pm
DSM
- MIA
2 stops44h 54m
Multiple Airlines
Deal found 5/21![Multiple Airlines logo]()
$130
This United Airlines deal was found by Cheapflights users on 5/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 8/123:02 pm
DSM
- MIA
1 stop6h 32m
United Airlines
Deal found 5/25![United Airlines logo]()
$134
This United Airlines deal was found by Cheapflights users on 5/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 11/178:00 am
DSM
- MIA
2 stops9h 35m
United Airlines
Deal found 5/21![United Airlines logo]()
$139
This Kiwi.com deal was found by Cheapflights users on 5/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 7/54:57 pm
DSM
- MIA
2 stops19h 56m
Multiple Airlines
Deal found 5/21![Multiple Airlines logo]()
$141
This Kiwi.com deal was found by Cheapflights users on 5/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 8/163:41 pm
DSM
- MIA
1 stop27h 45m
Multiple Airlines
Deal found 5/23![Multiple Airlines logo]()
$147
This Kiwi.com deal was found by Cheapflights users on 5/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 7/163:37 pm
DSM
- MIA
2 stops30h 28m
Multiple Airlines
Deal found 5/21![Multiple Airlines logo]()
$148
This Kiwi.com deal was found by Cheapflights users on 5/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 6/144:01 pm
DSM
- MIA
2 stops47h 30m
Multiple Airlines
Deal found 5/21![Multiple Airlines logo]()
$158
This Kiwi.com deal was found by Cheapflights users on 5/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 8/176:07 pm
DSM
- MIA
2 stops27h 56m
Multiple Airlines
Deal found 5/21![Multiple Airlines logo]()
$162
This Mytrip deal was found by Cheapflights users on 5/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 7/62:19 pm
DSM
- MIA
1 stop14h 32m
Frontier
Deal found 5/22![Frontier logo]()
$165
This Kiwi.com deal was found by Cheapflights users on 5/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 9/277:30 am
DSM
- EYW
3 stops27h 49m
Multiple Airlines
Deal found 5/25![Multiple Airlines logo]()
$217
This Delta deal was found by Cheapflights users on 5/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 9/275:44 am
DSM
- EYW
1 stop6h 14m
Delta
Deal found 5/25![Delta logo]()
$324
Find flight deals from Des Moines to Florida Keys
Keep the following information in mind while searching for Des Moines to Florida Keys flight deals. Data was last updated May 26, 2026.
Most accurate provider | FlightHub 3 stars |
|---|---|
Most trusted provider | FlightHub 3 stars |
Round-trip from | $267 (United Airlines) |
One-way from | $130 (Kiwi.com) |
Popular in | March |
Cheapest in | April |
Average price | $358 |
Cheapflights Fare Finder
Customize your flight search to find flights from Des Moines to Florida Keys that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated May 26, 2026.
Use the filters below to find and compare flights from Des Moines to Florida Keys that are best for you.
Fly from
Fly to
Route
Depart
Return
Cheapest round-trip
Des MoinesMiami
DSM - MIA
DSMMIA
Des Moines
Mon 10/26
3:15 pm-10:17 pm
1 stop6h 02m
Miami
Thu 10/29
4:06 pm-11:01 pm
1 stop7h 55m
$267
Des MoinesMiami
DSM - MIA
DSMMIA
Des Moines
Sat 9/12
8:00 am-6:52 pm
2 stops9h 52m
Miami
Wed 9/23
3:57 pm-9:27 pm
1 stop6h 30m
$272
Des MoinesMiami
DSM - MIA
DSMMIA
Des Moines
Thu 9/24
1:35 pm-9:57 pm
1 stop7h 22m
Miami
Wed 9/30
12:29 pm-5:33 pm
1 stop6h 04m
$313
Des MoinesKey West
DSM - EYW
DSMEYW
Des Moines
Wed 11/4
6:00 am-4:12 pm
2 stops9h 12m
Key West
Sat 11/7
4:26 pm-11:16 pm
1 stop7h 50m
$314
Des MoinesKey West
DSM - EYW
DSMEYW
Des Moines
Tue 6/16
11:28 am-7:53 pm
1 stop7h 25m
Key West
Wed 6/24
7:50 am-1:35 pm
1 stop6h 45m
$329
Des MoinesMiami
DSM - MIA
DSMMIA
Des Moines
Thu 7/30
5:10 am-10:05 pm
2 stops15h 55m
Miami
Thu 8/6
7:15 am-11:25 am
1 stop5h 10m
$339
Des MoinesMiami
DSM - MIA
DSMMIA
Des Moines
Tue 7/14
6:00 am-2:57 pm
1 stop7h 57m
Miami
Mon 7/20
4:10 pm-9:22 pm
1 stop6h 12m
$357
Quickest round-trip
Des MoinesKey West
DSM - EYW
DSMEYW
Des Moines
Wed 6/10
11:28 am-5:27 pm
1 stop4h 59m
Key West
Tue 6/16
6:24 pm-10:31 pm
1 stop5h 07m
$358
Des MoinesMiami
DSM - MIA
DSMMIA
Des Moines
Sat 10/31
6:15 am-8:37 pm
2 stops13h 22m
Miami
Sun 11/8
7:15 am-2:11 pm
1 stop7h 56m
$362
Des MoinesMiami
DSM - MIA
DSMMIA
Des Moines
Wed 10/28
8:00 am-8:37 pm
2 stops11h 37m
Miami
Tue 11/3
12:00 pm-7:25 pm
1 stop8h 25m
$362
Showing 1-10 of 25 resultsSorted by cheapest first
Best time to book a flight from Des Moines to Florida Keys
Have a flexible travel schedule? Discover the best time to fly to Florida Keys from Des Moines with our price prediction graph.
DSM-MIA
DSM-EYW
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.
Cheapflights Insights
Everything you need to know about your flight from Des Moines to Florida Keys
DSM-zzEOA
DSM-MIA
DSM-EYW
What is the cheapest month to book a flight from Des Moines to Florida Keys?
Currently, July is the cheapest month in which you can book a flight from Des Moines to Florida Keys (average of $76). Flying from Des Moines to Florida Keys in January is currently the most expensive (average of $237). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.
How far ahead should I book a flight from Des Moines to Florida Keys?
The price you pay for your flight from Des Moines to Florida Keys may vary depending on when you book. For the best chance of a lower fare, look to book 6 days in advance of your trip. Fares are likely to increase a fortnight or so before your departure date.
Reviews of airlines servicing Florida Keys
Get insights into the airlines that provide service to Florida Keys. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Florida Keys. Reviews last updated May 26, 2026.
Read reviews from past customers who have flown Southwest,Delta, andUnited Airlines from Des Moines to Florida Keys. You can also see how each airline compares in terms of entertainment options, comfort, food, crew/service, and boarding process.
Crew
8.6
Boarding
8.1
Comfort
8.0
Overall
7.9
Food
7.0
Entertainment
7.5
Reviews
1 / 20
2.0
MediocreDominic,Mar 2026
MCO - SMF
Crew
8.6
Boarding
8.1
Comfort
8.0
Overall
7.9
Food
7.0
Entertainment
7.5
Reviews
1 / 20
2.0
MediocreDominic,Mar 2026
MCO - SMF
Crew
8.6
Boarding
8.1
Comfort
8.0
Overall
7.9
Food
7.0
Entertainment
7.5
Reviews
1 / 20
2.0
MediocreDominic,Mar 2026
MCO - SMF
Crew
8.6
Boarding
8.1
Comfort
8.0
Overall
7.9
Food
7.0
Entertainment
7.5
Reviews
1 / 20
2.0
MediocreDominic,Mar 2026
MCO - SMF
Crew
8.6
Boarding
8.1
Comfort
8.0
Overall
7.9
Food
7.0
Entertainment
7.5
Reviews
1 / 20
2.0
MediocreDominic,Mar 2026
MCO - SMF
Crew
8.6
Boarding
8.1
Comfort
8.0
Overall
7.9
Food
7.0
Entertainment
7.5
Reviews
1 / 20
2.0
MediocreDominic,Mar 2026
MCO - SMF
Related info for your journey
Find useful and relevant information for your journey from Des Moines to Florida Keys. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.
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Des Moines and Florida Keys flights
Browse other Des Moines and Florida Keys flight options. Last updated on May 26, 2026.
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Top 4 airlines flying from Des Moines to Florida Keys
Discover the top 4 airlines that operate flights from Des Moines to Florida Keys. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated May 26, 2026.
| Airline | Cheapest | Average | Flexibility | On-time |
|---|---|---|---|---|
| Cheapest$76 | Average$102 | FlexibilityNo cancel fee | On-time88% | |
| Cheapest$268 | Average$426 | FlexibilityNo cancel fee | On-time69% | |
| Cheapest$268 | Average$434 | FlexibilityNo cancel fee | On-timeN/A | |
| Cheapest$274 | Average$465 | FlexibilityNo cancel fee | On-time71% |