HomeSearch by dateVacation packagesHotelsFlight dealsCar rentalTravel tips & news
Florence

$443+ Cheap flights from Syracuse to Florence, SC (SYR - FLO)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 5/29. Fares are subject to change and may not be available on all flights or dates of travel.
SYR — FLO
Jun 23 — Jun 301
Tue 6/23
Tue 6/30
1 adult, Economy
We work with more than 300 partners to bring you better travel deals

Find cheap flights from Syracuse to Florence with Cheapflights

1. Tell us where you want to go

Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”

2. Select your favorite providers

We find the providers serving your travel needs. Choose up to four travel providers to compare side-by-side for flights, hotels, or car rentals.

3. Compare prices and book

Review each provider’s pricing and select the best option for you! Book through your favorite provider’s website for a seamless experience.

Cheap flight deals from Syracuse to Florence

Cheapest flights from Syracuse to Florence
Explore the most affordable flight options available from Syracuse to Florence. Find the lowest fares from popular airlines and budget airlines, with prices last updated on May 24, 2026.

This American Airlines deal was found by Cheapflights users on 5/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 6/46:00 am
SYR
-
FLO
2 stops16h 00m
American Airlines
Mon 6/82:35 pm
FLO
-
SYR
2 stops9h 45m
American Airlines
Deal found 5/20$548
This American Airlines deal was found by Cheapflights users on 5/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 5/238:00 am
SYR
-
FLO
1 stop6h 10m
American Airlines
Mon 5/255:05 am
FLO
-
SYR
1 stop6h 17m
American Airlines
Deal found 5/22$624
This American Airlines deal was found by Cheapflights users on 5/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 6/228:00 am
SYR
-
FLO
1 stop6h 10m
American Airlines
Thu 6/252:35 pm
FLO
-
SYR
1 stop4h 04m
American Airlines
Deal found 5/19$885
This American Airlines deal was found by Cheapflights users on 5/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 7/67:34 pm
SYR
-
FLO
1 stop18h 36m
American Airlines
Mon 7/132:35 pm
FLO
-
SYR
1 stop20h 42m
American Airlines
Deal found 5/22$889

Find flight deals from Syracuse to Florence

Discover tips and strategies to find the most affordable flight options for your journey from Syracuse (SYR) to Florence (FLO). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated May 24, 2026.

Most accurate provider

FlightHub
3 stars

Most trusted provider

FlightHub
3 stars

Round-trip from

$548
(American Airlines)

One-way from

$443
(American Airlines)
Provider with most accurate pricing for Syracuse Hancock Intl-Florence flight deals.
Search Deals
Provider most trusted by Cheapflights users for Syracuse Hancock Intl-Florence flights.
Search Deals
From Syracuse Hancock Intl to Florence
Search Deals
One-way flight from Syracuse Hancock Intl to Florence
Search Deals

Cheapflights Fare Finder

 
Customize your flight search to find flights from Syracuse to Florence that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated May 24, 2026.
Use the filters below to find and compare flights from Syracuse to Florence that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Cheapest round-trip
Quickest round-trip

SyracuseFlorence

SYR - FLO

SYRFLO

Syracuse Hancock Intl

Thu 6/4

8:00 am-2:10 pm

1 stop6h 10m

Florence

Mon 6/8

2:35 pm-6:39 pm

1 stop4h 04m

$649

SyracuseFlorence

SYR - FLO

SYRFLO

Syracuse Hancock Intl

Mon 6/22

8:00 am-2:10 pm

1 stop6h 10m

Florence

Thu 6/25

2:35 pm-6:39 pm

1 stop4h 04m

$885

SyracuseFlorence

SYR - FLO

SYRFLO

Syracuse Hancock Intl

Mon 7/6

7:34 pm-2:10 pm

1 stop18h 36m

Florence

Mon 7/13

2:35 pm-11:17 am

1 stop20h 42m

$889
Cheapest one-way
Quickest one-way

SyracuseFlorence

SYR - FLO

SYRFLO

Syracuse Hancock Intl

Fri 5/29

8:00 am-2:10 pm

1 stop6h 10m

$443

Flights are sorted by cheapest round-trip flights first.

Deals found on 5/23

Sorted by cheapest first

Compare providers for flights from Syracuse to Florence

Provider information is updated monthly. Please note that these providers often have deals for this flight, but the availability may vary on a day-by-day basis on Cheapflights.
Use the table below to compare price accuracy, trust ratings, and cancellation policies for each provider offering flight deals from Syracuse to Florence in May.
ProviderPrice AccuracyTrust Score*
ExpediaPrice Accuracy1 starTrust Score*3 stars
FlightHubPrice Accuracy3 starsTrust Score*3 stars

*The Trust Score is based on feedback from users after their booking experience. It measures overall satisfaction, helping us identify issues like hidden fees, problems during the ticketing process, and the quality of customer service. This score is our best indicator of the provider's quality and reliability.

  • Most accurate provider: When it comes to deals on Syracuse-Florence, South Carolina flights, users find the pricing of FlightHub to be most consistent on Cheapflights vs. FlightHub Users can find the same prices on Syracuse-Florence, South Carolina flight deals on Cheapflights vs. FlightHub >95% of the time. Price accuracy is based on data collected from Syracuse-Florence, South Carolina flight searches over the past month and is updated monthly.
  • Most trusted provider: When it comes to deals on Syracuse-Florence, South Carolina flights, Cheapflights users trust FlightHub the most. FlightHub has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for Syracuse-Florence, South Carolina flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.

Best time to book a flight from Syracuse to Florence

Have a flexible travel schedule? Discover the best time to fly to Florence from Syracuse with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Reviews of airlines servicing Florence

Get insights into the airlines that provide service to Florence. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Florence. Reviews last updated May 24, 2026.
Get a feel of what it's like to fly with American Airlines from Syracuse to Florence by reading reviews from past customers. Users have also rated airlines in terms of entertainment options, comfort, food, crew/service, and boarding process.
American Airlines
7.1
Good
11,631 reviews

Entertainment

6.9

Food

6.4

Comfort

7.2

Overall

7.1

Boarding

7.5

Crew

7.9

Reviews

1 / 20
2.0
Mediocre

Anonymous,Apr 2026

DFW - BDL

They keep changing the gate, delaying the hours and then finally canceled it. No accomodation, no food, nothing!
American Airlines
7.1
Good
11,631 reviews
American Airlines
7.1
Good
11,631 reviews

Entertainment

6.9

Food

6.4

Comfort

7.2

Overall

7.1

Boarding

7.5

Crew

7.9

Reviews

1 / 20
2.0
Mediocre

Anonymous,Apr 2026

DFW - BDL

They keep changing the gate, delaying the hours and then finally canceled it. No accomodation, no food, nothing!

Related info for your journey

Find useful and relevant information for your journey from Syracuse to Florence. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • How long is the flight from Syracuse to Florence, South Carolina?

    A quick flight from Syracuse to Florence, South Carolina can take about 6h 10m. American Airlines provides one of the quickest options available for as low as $649. The distance from Syracuse to Florence, South Carolina is about 646 mi.

  • Can I find deals for flights from Syracuse to Florence that include hotel bookings?

    Yes. In addition to deals on Syracuse to Florence flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Syracuse to Florence?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Syracuse to Florence.

  • Can I find deals for business class flights from Syracuse to Florence?

    Yes. Cheapflights offers flight deals from Syracuse to Florence by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

See more FAQs

Traveling to a place near Florence?

Book flights to Florence if you plan to visit one of these locations
Sumter

Browse thousands of different options on Cheapflights for your next trip

Toggle through the tabs below to find thousands of options on Cheapflights for your next trip.

Alternative routes for Syracuse to Florence

See prices for flight routes from nearby airports that may be better suited for you.
Newark to Charlotte flights
John F Kennedy Intl to Charlotte flights
Newark to Charleston flights
LaGuardia to Charlotte flights
Newark to Myrtle Beach flights
LaGuardia to Myrtle Beach flights
John F Kennedy Intl to Charleston flights
LaGuardia to Charleston flights
John F Kennedy Intl to Myrtle Beach flights
Newark to Savannah flights
LaGuardia to Savannah flights
John F Kennedy Intl to Savannah flights
White Plains to Charleston flights
Newark to Greenville flights
Stewart to Myrtle Beach flights
LaGuardia to Greenville flights
Newark to Hilton Head Island flights
John F Kennedy Intl to Greenville flights
Newark to Columbia flights
White Plains to Myrtle Beach flights
LaGuardia to Hilton Head Island flights
John F Kennedy Intl to Columbia flights
LaGuardia to Columbia flights
Stewart to Charleston flights
Buffalo to Charlotte flights
Syracuse to Charlotte flights
Islip to Myrtle Beach flights
White Plains to Savannah flights
Stewart to Charlotte flights
Islip to Charleston flights
Buffalo to Charleston flights
Rochester to Charlotte flights
Albany to Charlotte flights
Syracuse to Savannah flights
Buffalo to Myrtle Beach flights
White Plains to Charlotte flights
Albany to Myrtle Beach flights
Islip to Charlotte flights
Rochester to Greenville flights
Albany to Savannah flights
John F Kennedy Intl to Augusta flights
Syracuse to Myrtle Beach flights
Rochester to Savannah flights
Newark to Augusta flights
Buffalo to Savannah flights
Syracuse to Charleston flights
Syracuse to Greenville flights
Rochester to Charleston flights
Rochester to Myrtle Beach flights

Top airline flying from Syracuse to Florence

Discover the top airline that operate flights from Syracuse to Florence. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated May 24, 2026.
AirlineCheapestAverageFlexibilityOn-time
American AirlinesCheapest$412Average$516FlexibilityNo cancel feeOn-time71%

100% Free

Cheapflights is completely free to use, so you can start saving the moment you arrive.

Book with Flexibility

Our users can plan ahead with confidence and find flights with no change fees

Travel Smart

Millions of people come to us for their flight needs every year. We help make travel planning easy by providing useful insights and data-driven graphs that can inform your decisions.