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Florence

$292+ Cheap flights from Syracuse to Florence, SC (SYR - FLO)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 5/6. Fares are subject to change and may not be available on all flights or dates of travel.
SYR — FLO
Apr 11 — Apr 181
Sat 4/11
Sat 4/18
1 adult, Economy
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Cheap flight deals from Syracuse to Florence

Cheapest flights from Syracuse to Florence
Explore the most affordable flight options available from Syracuse to Florence. Find the lowest fares from popular airlines and budget airlines, with prices last updated on March 12, 2026.

This American Airlines deal was found by Cheapflights users on 3/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 8/251:01 pm
SYR
-
FLO
2 stops11h 01m
American Airlines
Tue 9/811:15 am
FLO
-
SYR
1 stop5h 14m
American Airlines
Deal found 3/8$414
This American Airlines deal was found by Cheapflights users on 3/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 8/251:01 pm
SYR
-
FLO
2 stops11h 01m
American Airlines
Mon 8/315:14 am
FLO
-
SYR
1 stop6h 05m
American Airlines
Deal found 3/8$448
This American Airlines deal was found by Cheapflights users on 3/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 4/296:10 am
SYR
-
FLO
2 stops9h 40m
American Airlines
Mon 5/44:16 pm
FLO
-
SYR
1 stop6h 48m
American Airlines
Deal found 3/8$492
This American Airlines deal was found by Cheapflights users on 3/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 4/166:10 am
SYR
-
FLO
2 stops9h 40m
American Airlines
Sun 4/195:20 am
FLO
-
SYR
2 stops10h 25m
American Airlines
Deal found 3/11$493
This American Airlines deal was found by Cheapflights users on 3/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 3/244:59 pm
SYR
-
FLO
2 stops6h 09m
American Airlines
Sat 3/285:16 am
FLO
-
SYR
2 stops10h 19m
American Airlines
Deal found 3/8$503
This American Airlines deal was found by Cheapflights users on 3/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 9/45:19 pm
SYR
-
FLO
1 stop6h 43m
American Airlines
Mon 9/711:15 am
FLO
-
SYR
1 stop5h 14m
American Airlines
Deal found 3/11$541

Find flight deals from Syracuse to Florence

Discover tips and strategies to find the most affordable flight options for your journey from Syracuse (SYR) to Florence (FLO). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated March 12, 2026.

Most accurate provider

FlightHub
3 stars

Most trusted provider

FlightHub
3 stars

Round-trip from

$414
(American Airlines)

One-way from

$292
(American Airlines)
Provider with most accurate pricing for Syracuse Hancock Intl-Florence flight deals.
Search Deals
Provider most trusted by Cheapflights users for Syracuse Hancock Intl-Florence flights.
Search Deals
From Syracuse Hancock Intl to Florence
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One-way flight from Syracuse Hancock Intl to Florence
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Cheapflights Fare Finder

 
Customize your flight search to find flights from Syracuse to Florence that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated March 12, 2026.
Use the filters below to find and compare flights from Syracuse to Florence that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Cheapest round-trip

SyracuseFlorence

SYR - FLO

SYRFLO

Syracuse Hancock Intl

Tue 8/25

1:01 pm-12:02 am

2 stops11h 01m

Florence

Tue 9/8

11:15 am-4:29 pm

1 stop5h 14m

$414

SyracuseFlorence

SYR - FLO

SYRFLO

Syracuse Hancock Intl

Tue 8/25

1:01 pm-12:02 am

2 stops11h 01m

Florence

Mon 8/31

5:14 am-11:19 am

1 stop6h 05m

$448

SyracuseFlorence

SYR - FLO

SYRFLO

Syracuse Hancock Intl

Wed 4/29

6:10 am-3:50 pm

2 stops9h 40m

Florence

Mon 5/4

4:16 pm-11:04 pm

1 stop6h 48m

$492

SyracuseFlorence

SYR - FLO

SYRFLO

Syracuse Hancock Intl

Thu 4/16

6:10 am-3:50 pm

2 stops9h 40m

Florence

Sun 4/19

5:20 am-3:45 pm

2 stops10h 25m

$493

SyracuseFlorence

SYR - FLO

SYRFLO

Syracuse Hancock Intl

Tue 3/24

4:59 pm-11:08 pm

2 stops6h 09m

Florence

Sat 3/28

5:16 am-3:35 pm

2 stops10h 19m

$503
Quickest round-trip

SyracuseFlorence

SYR - FLO

SYRFLO

Syracuse Hancock Intl

Fri 9/4

5:19 pm-12:02 am

1 stop6h 43m

Florence

Mon 9/7

11:15 am-4:29 pm

1 stop5h 14m

$541

SyracuseFlorence

SYR - FLO

SYRFLO

Syracuse Hancock Intl

Sat 4/4

5:24 pm-11:57 pm

2 stops6h 33m

Florence

Tue 4/7

4:02 pm-10:39 pm

1 stop6h 37m

$638
Cheapest one-way

SyracuseFlorence

SYR - FLO

SYRFLO

Syracuse Hancock Intl

Thu 5/7

5:30 am-3:50 pm

2 stops10h 20m

$311

SyracuseFlorence

SYR - FLO

SYRFLO

Syracuse Hancock Intl

Wed 8/26

12:20 pm-12:02 am

2 stops11h 42m

$312

SyracuseFlorence

SYR - FLO

SYRFLO

Syracuse Hancock Intl

Sun 8/23

8:18 pm-10:50 am

2 stops14h 32m

$332

Flights are sorted by cheapest round-trip flights first.

Deals found on 3/10

Showing 1-10 of 14 resultsSorted by cheapest first
1
2

Compare providers for flights from Syracuse to Florence

Provider information is updated monthly. Please note that these providers often have deals for this flight, but the availability may vary on a day-by-day basis on Cheapflights.
Use the table below to compare price accuracy, trust ratings, and cancellation policies for each provider offering flight deals from Syracuse to Florence in March.
ProviderPrice AccuracyTrust Score*
ExpediaPrice Accuracy1 starTrust Score*3 stars
FlightHubPrice Accuracy3 starsTrust Score*3 stars

*The Trust Score is based on feedback from users after their booking experience. It measures overall satisfaction, helping us identify issues like hidden fees, problems during the ticketing process, and the quality of customer service. This score is our best indicator of the provider's quality and reliability.

  • Most accurate provider: When it comes to deals on Syracuse-Florence, South Carolina flights, users find the pricing of FlightHub to be most consistent on Cheapflights vs. FlightHub Users can find the same prices on Syracuse-Florence, South Carolina flight deals on Cheapflights vs. FlightHub >95% of the time. Price accuracy is based on data collected from Syracuse-Florence, South Carolina flight searches over the past month and is updated monthly.
  • Most trusted provider: When it comes to deals on Syracuse-Florence, South Carolina flights, Cheapflights users trust FlightHub the most. FlightHub has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for Syracuse-Florence, South Carolina flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.

Best time to book a flight from Syracuse to Florence

Have a flexible travel schedule? Discover the best time to fly to Florence from Syracuse with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Syracuse to Florence

What is the cheapest month to book a flight from Syracuse to Florence, South Carolina?

Currently, April is the cheapest month in which you can book a flight from Syracuse to Florence, South Carolina (average of $48). Flying from Syracuse to Florence, South Carolina in August is currently the most expensive (average of $115). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

Related info for your journey

Find useful and relevant information for your journey from Syracuse to Florence. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • How long is the flight from Syracuse to Florence, South Carolina?

    A quick flight from Syracuse to Florence, South Carolina can take about 11h 01m. American Airlines provides one of the quickest options available for as low as $414. The distance from Syracuse to Florence, South Carolina is about 646 mi.

  • Can I find deals for flights from Syracuse to Florence that include hotel bookings?

    Yes. In addition to deals on Syracuse to Florence flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Syracuse to Florence?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Syracuse to Florence.

  • Can I find deals for business class flights from Syracuse to Florence?

    Yes. Cheapflights offers flight deals from Syracuse to Florence by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Syracuse to Florence, South Carolina?

    Currently, April is the cheapest month in which you can book a flight from Syracuse to Florence, South Carolina (average of $48). Flying from Syracuse to Florence, South Carolina in August is currently the most expensive (average of $115). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Traveling to a place near Florence?

Book flights to Florence if you plan to visit one of these locations
Sumter
Hartsville
Darlington

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