HomeSearch by dateVacation packagesHotelsFlight dealsCar rentalTravel tips & news
Florence

$191+ Cheap flights from St. Louis to Florence, SC (STL - FLO)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 12/24. Fares are subject to change and may not be available on all flights or dates of travel.
STL — FLO
Oct 11 — Oct 181
Sat 10/11
Sat 10/18
1 adult, Economy
We work with more than 300 partners to bring you better travel deals

Find cheap flights from St. Louis to Florence with Cheapflights

1. Tell us where you want to go

Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”

2. Select your favorite providers

We find the providers serving your travel needs. Choose up to four travel providers to compare side-by-side for flights, hotels, or car rentals.

3. Compare prices and book

Review each provider’s pricing and select the best option for you! Book through your favorite provider’s website for a seamless experience.

Cheap flight deals from St. Louis to Florence

Discover tips and strategies to find the most affordable flight options for your journey from St. Louis (STL) to Florence (FLO). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated September 11, 2025.

Round-trip from

$490
(American Airlines)

One-way from

$191
(American Airlines)
From Lambert-St Louis to Florence
Search Deals
One-way flight from Lambert-St Louis to Florence
Search Deals

Find flight deals from St. Louis to Florence

Cheapest flights from St. Louis to Florence
Explore the most affordable flight options available from St. Louis to Florence. Find the lowest fares from popular airlines and budget airlines, with prices last updated on September 11, 2025.

This American Airlines deal was found by Cheapflights users on 9/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 11/46:00 amSTL - FLO
2 stops15h 53mAmerican Airlines
Thu 11/65:15 amFLO - STL
2 stops11h 57mAmerican Airlines
Deal found 9/10$490

Cheapflights Fare Finder

 
Customize your flight search to find flights from St. Louis to Florence that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated September 11, 2025.
Use the filters below to find and compare flights from St. Louis to Florence that are best for you.

Fly from

St. Louis

Fly to

Florence

Route

Depart

Return

Price

St. LouisFlorence

STL - FLO

STLFLO

Lambert-St Louis

Tue 11/4

6:00 am-10:53 pm

2 stops15h 53m

Florence

Thu 11/6

5:15 am-4:12 pm

2 stops11h 57m

$490

St. LouisFlorence

STL - FLO

STLFLO

Lambert-St Louis

Tue 9/16

9:57 am-5:12 pm

1 stop6h 15m

$384

Flights are sorted by cheapest round-trip flights first.

Deals found on 9/9

Best time to book a flight from St. Louis to Florence

Have a flexible travel schedule? Discover the best time to fly to Florence from St. Louis with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from St. Louis to Florence

What is the cheapest month to book a flight from St. Louis to Florence, South Carolina?

Currently, January is the cheapest month in which you can book a flight from St. Louis to Florence, South Carolina (average of $366). Flying from St. Louis to Florence, South Carolina in October is currently the most expensive (average of $501). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

Related info for your journey

Find useful and relevant information for your journey from St. Louis to Florence. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • How long is the flight from St. Louis to Florence, South Carolina?

    For as low as $490, American Airlines can have you in Florence, South Carolina from St. Louis in 15h 53m. The distance between St. Louis and Florence, South Carolina is about 669 mi.

  • Can I find deals for flights from St. Louis to Florence that include hotel bookings?

    Yes. In addition to deals on St. Louis to Florence flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from St. Louis to Florence?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from St. Louis to Florence.

  • Can I find deals for business class flights from St. Louis to Florence?

    Yes. Cheapflights offers flight deals from St. Louis to Florence by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from St. Louis to Florence, South Carolina?

    Currently, January is the cheapest month in which you can book a flight from St. Louis to Florence, South Carolina (average of $366). Flying from St. Louis to Florence, South Carolina in October is currently the most expensive (average of $501). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Traveling to a place near Florence?

Book flights to Florence if you plan to visit one of these locations
Sumter
Hartsville
Darlington

Browse thousands of different options on Cheapflights for your next trip

Toggle through the tabs below to find thousands of options on Cheapflights for your next trip.

Alternative routes for St. Louis to Florence

See prices for flight routes from nearby airports that may be better suited for you.
St. Louis to Charlotte flights
Kansas City to Charlotte flights
St. Louis to Charleston flights
St. Louis to Augusta flights
Kansas City to Savannah flights
Kansas City to Columbia flights
Kansas City to Charleston flights
St. Louis to Savannah flights
St. Louis to Columbia flights
St. Louis to Myrtle Beach flights
Springfield to Columbia flights
Kansas City to Myrtle Beach flights
Kansas City to Hilton Head Island flights
St. Louis to Greenville flights
Springfield to Charlotte flights
Springfield to Charleston flights
Kansas City to Greenville flights
Springfield to Savannah flights
Springfield to Myrtle Beach flights
St. Louis to Hilton Head Island flights
Springfield to Hilton Head Island flights
Joplin to Charlotte flights
Springfield to Greenville flights
Columbia to Charlotte flights
Springfield to Augusta flights
Columbia to Charleston flights
Kansas City to Augusta flights
Joplin to Charleston flights
Joplin to Columbia flights
Joplin to Augusta flights
Kansas City to Florence flights
Joplin to Savannah flights
Columbia to Hilton Head Island flights
Columbia to Myrtle Beach flights
Cape Girardeau to Charlotte flights
Joplin to Hilton Head Island flights

100% Free

Cheapflights is completely free to use, so you can start saving the moment you arrive.

Book with Flexibility

Our users can plan ahead with confidence and find flights with no change fees

Travel Smart

Millions of people come to us for their flight needs every year. We help make travel planning easy by providing useful insights and data-driven graphs that can inform your decisions.