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$383+ Cheap flights from St. Louis to Florence, SC (STL - FLO)

This is the cheapest round-trip flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 8/27. Fares are subject to change and may not be available on all flights or dates of travel.
STL — FLO
Aug 3 — Aug 101
Sun 8/3
Sun 8/10
1 adult, Economy
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Cheap flight deals from St. Louis to Florence

Discover tips and strategies to find the most affordable flight options for your journey from St. Louis (STL) to Florence (FLO). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated July 29, 2025.

Round-trip from

$383
(American Airlines)
From Lambert-St Louis to Florence
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Find flight deals from St. Louis to Florence

Cheapest flights from St. Louis to Florence
Explore the most affordable flight options available from St. Louis to Florence. Find the lowest fares from popular airlines and budget airlines, with prices last updated on July 29, 2025.

This American Airlines deal was found by Cheapflights users on 7/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 8/276:26 amSTL - FLO
1 stop4h 20mAmerican Airlines
Wed 9/36:14 amFLO - STL
1 stop4h 03mAmerican Airlines
Deal found 7/28$383

Cheapflights Fare Finder

 
Customize your flight search to find flights from St. Louis to Florence that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated July 29, 2025.
Use the filters below to find and compare flights from St. Louis to Florence that are best for you.

Fly from

St. Louis

Fly to

Florence

Route

Depart

Return

Price

St. LouisFlorence

STL - FLO

STLFLO

Lambert-St Louis

Wed 8/27

6:26 am-11:46 am

1 stop4h 20m

Florence

Wed 9/3

6:14 am-9:17 am

1 stop4h 03m

$383

Flights are sorted by cheapest round-trip flights first.

Deals found on 7/28

Best time to book a flight from St. Louis to Florence

Have a flexible travel schedule? Discover the best time to fly to Florence from St. Louis with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from St. Louis to Florence

What is the cheapest month to book a flight from St. Louis to Florence, South Carolina?

Currently, January is the cheapest month in which you can book a flight from St. Louis to Florence, South Carolina (average of $366). Flying from St. Louis to Florence, South Carolina in October is currently the most expensive (average of $487). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

Reviews of airlines servicing Florence

Get insights into the airlines that provide service to Florence. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Florence. Reviews last updated July 29, 2025.
Get a feel of what it's like to fly with American Airlines from St. Louis to Florence by reading reviews from past customers. Users have also rated airlines in terms of entertainment options, comfort, food, crew/service, and boarding process.
American Airlines
7.2
Good
10,000 reviews

Entertainment

6.9

Food

6.5

Crew

8.0

Overall

7.2

Boarding

7.5

Comfort

7.2

Reviews

1 / 20
2.0
Mediocre

Andrew,May 2025

LAX - MIA

2 hour delay. Discovered an engine problem late, we boarded the plane and they asked us to come off. To add insult to injury nothing was given to passengers to make amends. No free drink. No extra food or snacks. No free WiFi. Gimme a break
American Airlines
7.2
Good
10,000 reviews
American Airlines
7.2
Good
10,000 reviews

Entertainment

6.9

Food

6.5

Crew

8.0

Overall

7.2

Boarding

7.5

Comfort

7.2

Reviews

1 / 20
2.0
Mediocre

Andrew,May 2025

LAX - MIA

2 hour delay. Discovered an engine problem late, we boarded the plane and they asked us to come off. To add insult to injury nothing was given to passengers to make amends. No free drink. No extra food or snacks. No free WiFi. Gimme a break

Related info for your journey

Find useful and relevant information for your journey from St. Louis to Florence. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What is the cheapest airline to fly from St. Louis to Florence, South Carolina round-trip?

    Flying on American Airlines is currently your cheapest option to Florence, South Carolina, with prices starting at $383.

  • Can I find deals for flights from St. Louis to Florence that include hotel bookings?

    Yes. In addition to deals on St. Louis to Florence flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from St. Louis to Florence?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from St. Louis to Florence.

  • Can I find deals for business class flights from St. Louis to Florence?

    Yes. Cheapflights offers flight deals from St. Louis to Florence by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from St. Louis to Florence, South Carolina?

    Currently, January is the cheapest month in which you can book a flight from St. Louis to Florence, South Carolina (average of $366). Flying from St. Louis to Florence, South Carolina in October is currently the most expensive (average of $487). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Traveling to a place near Florence?

Book flights to Florence if you plan to visit one of these locations
Sumter
Hartsville
Darlington

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