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Florence

$219+ Cheap flights from Michigan to Florence, SC (FLO)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 9/30. Fares are subject to change and may not be available on all flights or dates of travel.
DTW — FLO
Oct 17 — Oct 241
Fri 10/17
Fri 10/24
1 adult, Economy
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Cheap flight deals from Michigan to Florence

Keep the following information in mind while searching for Michigan to Florence flight deals. Data was last updated September 17, 2025.

Round-trip from

$333
(American Airlines)

One-way from

$219
(American Airlines)
From Michigan to Florence
Search Deals
One-way flight from Michigan to Florence
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Find flight deals from Michigan to Florence

Cheapest flights from Michigan to Florence
Explore the most affordable flight options available from Michigan to Florence. Find the lowest fares from popular airlines and budget airlines, with prices last updated on September 17, 2025.

This American Airlines deal was found by Cheapflights users on 9/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/156:00 amFNT - FLO
2 stops8h 54mAmerican Airlines
Wed 10/223:19 pmFLO - FNT
2 stops7h 50mAmerican Airlines
Deal found 9/17$354
This American Airlines deal was found by Cheapflights users on 9/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 10/141:02 pmDTW - FLO
2 stops10h 11mAmerican Airlines
Tue 10/216:14 amFLO - DTW
2 stops10h 14mAmerican Airlines
Deal found 9/16$378
This American Airlines deal was found by Cheapflights users on 9/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/275:00 amORD - FLO
1 stop4h 45mAmerican Airlines
Mon 12/810:28 amFLO - ORD
1 stop5h 41mAmerican Airlines
Deal found 9/15$393
This American Airlines deal was found by Cheapflights users on 9/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/32:33 pmFNT - FLO
2 stops8h 43mAmerican Airlines
Mon 10/611:11 amFLO - FNT
2 stops11h 58mAmerican Airlines
Deal found 9/17$419
This American Airlines deal was found by Cheapflights users on 9/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 9/305:08 pmORD - FLO
1 stop5h 08mAmerican Airlines
Sat 10/46:14 amFLO - ORD
1 stop5h 29mAmerican Airlines
Deal found 9/15$437
This American Airlines deal was found by Cheapflights users on 9/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/159:20 amORD - FLO
1 stop4h 34mAmerican Airlines
Tue 10/216:14 amFLO - ORD
1 stop5h 18mAmerican Airlines
Deal found 9/15$463
This American Airlines deal was found by Cheapflights users on 9/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/157:10 amORD - FLO
1 stop6h 44mAmerican Airlines
Thu 10/235:14 amFLO - ORD
2 stops7h 49mAmerican Airlines
Deal found 9/15$468
This American Airlines deal was found by Cheapflights users on 9/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/11:03 pmGRR - FLO
1 stop4h 09mAmerican Airlines
Sun 10/54:57 pmFLO - GRR
1 stop5h 30mAmerican Airlines
Deal found 9/16$480
This American Airlines deal was found by Cheapflights users on 9/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/165:22 amORD - FLO
1 stop4h 24mAmerican Airlines
Wed 10/223:19 pmFLO - ORD
2 stops9h 31mAmerican Airlines
Deal found 9/15$490
This American Airlines deal was found by Cheapflights users on 9/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/181:14 pmORD - FLO
2 stops9h 49mAmerican Airlines
Thu 10/235:14 amFLO - ORD
2 stops9h 38mAmerican Airlines
Deal found 9/15$495
This American Airlines deal was found by Cheapflights users on 9/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/26:35 pmORD - FLO
1 stop4h 38mAmerican Airlines
Sun 10/55:14 amFLO - ORD
1 stop5h 11mAmerican Airlines
Deal found 9/14$496
This American Airlines deal was found by Cheapflights users on 9/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/412:42 pmDTW - FLO
2 stops10h 34mAmerican Airlines
Tue 10/73:19 pmFLO - DTW
2 stops17h 58mAmerican Airlines
Deal found 9/14$508

Cheapflights Fare Finder

 
Customize your flight search to find flights from Michigan to Florence that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated September 17, 2025.
Use the filters below to find and compare flights from Michigan to Florence that are best for you.

Fly from

Michigan

Fly to

Florence

Route

Depart

Return

Price

LansingFlorence

LAN - FLO

LANFLO

Lansing Capital City

Wed 3/4

5:17 pm-11:29 pm

2 stops6h 12m

Florence

Wed 3/18

2:30 pm-10:28 pm

2 stops7h 58m

$333

FlintFlorence

FNT - FLO

FNTFLO

Flint Bishop

Wed 10/15

6:00 am-2:54 pm

2 stops8h 54m

Florence

Wed 10/22

3:19 pm-11:09 pm

2 stops7h 50m

$354

DetroitFlorence

DTW - FLO

DTWFLO

Detroit Metropolitan Wayne County

Tue 10/14

1:02 pm-11:13 pm

2 stops10h 11m

Florence

Tue 10/21

6:14 am-4:28 pm

2 stops10h 14m

$378

ChicagoFlorence

ORD - FLO

ORDFLO

Chicago O'Hare Intl

Sun 10/19

8:15 am-2:04 pm

1 stop4h 49m

Florence

Mon 10/20

11:11 am-4:05 pm

1 stop5h 54m

$393

ChicagoFlorence

ORD - FLO

ORDFLO

Chicago O'Hare Intl

Sat 2/14

4:40 pm-11:29 pm

1 stop5h 49m

Florence

Tue 2/24

2:33 pm-7:29 pm

1 stop5h 56m

$393

ChicagoFlorence

ORD - FLO

ORDFLO

Chicago O'Hare Intl

Thu 11/27

5:00 am-10:45 am

1 stop4h 45m

Florence

Mon 12/8

5:35 pm-11:39 pm

1 stop7h 04m

$393

ChicagoFlorence

ORD - FLO

ORDFLO

Chicago O'Hare Intl

Sat 11/1

10:00 am-7:47 pm

2 stops8h 47m

Florence

Fri 11/7

6:15 am-12:28 pm

1 stop7h 13m

$398

FlintFlorence

FNT - FLO

FNTFLO

Flint Bishop

Fri 10/3

2:33 pm-11:16 pm

2 stops8h 43m

Florence

Mon 10/6

11:11 am-11:09 pm

2 stops11h 58m

$419

ChicagoFlorence

ORD - FLO

ORDFLO

Chicago O'Hare Intl

Thu 10/2

6:35 pm-12:13 am

1 stop4h 38m

Florence

Mon 10/6

11:11 am-4:05 pm

1 stop5h 54m

$437

ChicagoFlorence

ORD - FLO

ORDFLO

Chicago O'Hare Intl

Tue 9/30

3:33 pm-11:16 pm

2 stops6h 43m

Florence

Sat 10/4

6:14 am-11:06 am

2 stops5h 52m

$447

Flights are sorted by cheapest round-trip flights first.

Deals found on 9/16

Showing 1-10 of 16 results
1
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Best time to book a flight from Michigan to Florence

Have a flexible travel schedule? Discover the best time to fly to Florence from Michigan with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Michigan to Florence

What is the cheapest month to book a flight from Michigan to Florence, South Carolina?

Currently, January is the cheapest month in which you can book a flight from Michigan to Florence, South Carolina (average of $366). Flying from Michigan to Florence, South Carolina in October is currently the most expensive (average of $501). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

Related info for your journey

Find useful and relevant information for your journey from Michigan to Florence. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airport do you fly into for flights to Florence from Michigan?

    If you book a flight to Florence from Michigan, you will be flying to Florence, which is the city’s only airport. Florence (FLO) is located 2.3 mi from the center of Florence.

  • How long is the flight from Michigan to Florence, South Carolina?

    For as low as $333, American Airlines can have you in Florence, South Carolina from Michigan in 6h 12m. Michigan and Florence, South Carolina are separated by a distance of 649 mi.

  • What are the most popular routes from Michigan to Florence, South Carolina?

    While some choose either Detroit Metropolitan Wayne County - Florence or Flint Bishop - Florence, Chicago O'Hare Intl - Florence is the most popular route from Michigan to Florence, South Carolina.

  • Can I find deals for flights from Michigan to Florence that include hotel bookings?

    Yes. In addition to deals on Michigan to Florence flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Michigan to Florence?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Michigan to Florence.

  • Can I find deals for business class flights from Michigan to Florence?

    Yes. Cheapflights offers flight deals from Michigan to Florence by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Michigan to Florence, South Carolina?

    Currently, January is the cheapest month in which you can book a flight from Michigan to Florence, South Carolina (average of $366). Flying from Michigan to Florence, South Carolina in October is currently the most expensive (average of $501). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Traveling to a place near Florence?

Book flights to Florence if you plan to visit one of these locations
Sumter
Hartsville
Darlington

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