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Florence

$401+ Cheap flights from Michigan to Florence, SC (FLO)

This is the cheapest round-trip flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 3/30. Fares are subject to change and may not be available on all flights or dates of travel.
DTW — FLO
Mar 5 — Mar 121
Thu 3/5
Thu 3/12
1 adult, Economy
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Cheap flight deals from Michigan to Florence

Cheapest flights from Michigan to Florence
Explore the most affordable flight options available from Michigan to Florence. Find the lowest fares from popular airlines and budget airlines, with prices last updated on February 3, 2026.

This American Airlines deal was found by Cheapflights users on 2/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 3/305:00 pm
ORD
-
FLO
1 stop5h 57m
American Airlines
Thu 4/25:16 am
FLO
-
ORD
1 stop4h 52m
American Airlines
Deal found 2/1$401
This American Airlines deal was found by Cheapflights users on 2/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 3/41:11 pm
GRR
-
FLO
1 stop4h 10m
American Airlines
Sun 3/86:20 pm
FLO
-
GRR
1 stop6h 21m
American Airlines
Deal found 2/1$444
This American Airlines deal was found by Cheapflights users on 2/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 2/1810:28 am
ORD
-
FLO
1 stop5h 53m
American Airlines
Fri 2/205:16 am
FLO
-
ORD
1 stop4h 49m
American Airlines
Deal found 2/3$457
This American Airlines deal was found by Cheapflights users on 1/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 3/286:48 pm
ORD
-
FLO
1 stop4h 09m
American Airlines
Tue 3/316:15 am
FLO
-
ORD
2 stops7h 01m
American Airlines
Deal found 1/31$482
This American Airlines deal was found by Cheapflights users on 2/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 3/1412:28 pm
FNT
-
FLO
2 stops11h 29m
American Airlines
Tue 3/175:58 pm
FLO
-
FNT
2 stops17h 57m
American Airlines
Deal found 2/2$483
This American Airlines deal was found by Cheapflights users on 2/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 3/205:00 pm
ORD
-
FLO
1 stop5h 57m
American Airlines
Fri 3/275:16 am
FLO
-
ORD
1 stop4h 52m
American Airlines
Deal found 2/3$596
This American Airlines deal was found by Cheapflights users on 2/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 2/155:00 pm
ORD
-
FLO
1 stop5h 57m
American Airlines
Thu 2/196:20 pm
FLO
-
ORD
1 stop6h 56m
American Airlines
Deal found 2/2$599
This American Airlines deal was found by Cheapflights users on 2/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 3/286:22 am
LAN
-
FLO
2 stops17h 35m
American Airlines
Wed 4/15:16 am
FLO
-
LAN
2 stops17h 49m
American Airlines
Deal found 2/1$701
This American Airlines deal was found by Cheapflights users on 2/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 3/2711:51 am
DTW
-
FLO
1 stop5h 59m
American Airlines
Sat 4/45:16 am
FLO
-
DTW
1 stop4h 09m
American Airlines
Deal found 2/2$712
This American Airlines deal was found by Cheapflights users on 2/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 2/145:40 am
FNT
-
FLO
2 stops12h 10m
American Airlines
Mon 2/166:20 pm
FLO
-
FNT
2 stops17h 35m
American Airlines
Deal found 2/2$760
This American Airlines deal was found by Cheapflights users on 2/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 2/46:17 pm
DTW
-
FLO
1 stop4h 26m
American Airlines
Fri 2/65:36 pm
FLO
-
DTW
1 stop17h 47m
American Airlines
Deal found 2/2$770

Find flight deals from Michigan to Florence

Keep the following information in mind while searching for Michigan to Florence flight deals. Data was last updated February 3, 2026.

Most accurate provider

FlightHub
3 stars

Most trusted provider

FlightHub
3 stars

Round-trip from

$401
(American Airlines)
Provider with most accurate pricing for Detroit (DTT)-Florence flight deals.
Search Deals
Provider most trusted by Cheapflights users for Detroit (DTT)-Florence flights.
Search Deals
From Michigan to Florence
Search Deals

Cheapflights Fare Finder

 
Customize your flight search to find flights from Michigan to Florence that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated February 3, 2026.
Use the filters below to find and compare flights from Michigan to Florence that are best for you.

Fly from

Michigan

Fly to

Florence

Route

Depart

Return

Price

ChicagoFlorence

ORD - FLO

ORDFLO

Chicago O'Hare Intl

Sat 3/28

6:48 pm-11:57 pm

1 stop4h 09m

Florence

Tue 3/31

5:58 pm-12:06 am

1 stop7h 08m

$401

ChicagoFlorence

ORD - FLO

ORDFLO

Chicago O'Hare Intl

Mon 3/30

5:00 pm-11:57 pm

1 stop5h 57m

Florence

Thu 4/2

5:16 am-9:08 am

1 stop4h 52m

$401

Grand RapidsFlorence

GRR - FLO

GRRFLO

Grand Rapids Gerald R. Ford Intl

Wed 3/4

1:11 pm-5:21 pm

1 stop4h 10m

Florence

Sun 3/8

6:20 pm-12:41 am

1 stop6h 21m

$444

ChicagoFlorence

ORD - FLO

ORDFLO

Chicago O'Hare Intl

Wed 2/18

10:28 am-5:21 pm

1 stop5h 53m

Florence

Fri 2/20

5:16 am-9:05 am

1 stop4h 49m

$457

FlintFlorence

FNT - FLO

FNTFLO

Flint Bishop

Sat 3/14

12:28 pm-11:57 pm

2 stops11h 29m

Florence

Tue 3/17

5:58 pm-11:55 am

2 stops17h 57m

$483

ChicagoFlorence

ORD - FLO

ORDFLO

Chicago O'Hare Intl

Fri 3/20

5:00 pm-11:57 pm

1 stop5h 57m

Florence

Fri 3/27

5:16 am-9:08 am

1 stop4h 52m

$596

LansingFlorence

LAN - FLO

LANFLO

Lansing Capital City

Sat 3/28

6:22 am-11:57 pm

2 stops17h 35m

Florence

Wed 4/1

5:16 am-11:05 pm

2 stops17h 49m

$701

DetroitFlorence

DTW - FLO

DTWFLO

Detroit Metropolitan Wayne County

Fri 3/27

11:51 am-5:50 pm

1 stop5h 59m

Florence

Sat 4/4

5:16 am-9:25 am

1 stop4h 09m

$712

DetroitFlorence

DTW - FLO

DTWFLO

Detroit Metropolitan Wayne County

Mon 2/16

5:45 am-5:50 pm

2 stops12h 05m

Florence

Fri 2/20

6:20 pm-9:56 am

2 stops15h 36m

$727

FlintFlorence

FNT - FLO

FNTFLO

Flint Bishop

Sat 2/14

5:40 am-5:50 pm

2 stops12h 10m

Florence

Mon 2/16

6:20 pm-11:55 am

2 stops17h 35m

$760

Flights are sorted by cheapest round-trip flights first.

Deals found on 2/1

Showing 1-10 of 11 results
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Best time to book a flight from Michigan to Florence

Have a flexible travel schedule? Discover the best time to fly to Florence from Michigan with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Michigan to Florence

What is the cheapest month to book a flight from Michigan to Florence, South Carolina?

Currently, August is the cheapest month in which you can book a flight from Michigan to Florence, South Carolina (average of $78). Flying from Michigan to Florence, South Carolina in December is currently the most expensive (average of $151). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

Related info for your journey

Find useful and relevant information for your journey from Michigan to Florence. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airport do you fly into for flights to Florence from Michigan?

    If you book a flight to Florence from Michigan, you will be flying to Florence, which is the city’s only airport. Florence (FLO) is located 2.3 mi from the center of Florence.

  • How long is the flight from Michigan to Florence, South Carolina?

    For as low as $401, American Airlines can have you in Florence, South Carolina from Michigan in 4h 09m. Michigan and Florence, South Carolina are separated by a distance of 697 mi.

  • What are the most popular routes from Michigan to Florence, South Carolina?

    While some choose either Chicago O'Hare Intl - Florence or Flint Bishop - Florence, Detroit Metropolitan Wayne County - Florence is the most popular route from Michigan to Florence, South Carolina.

  • Can I find deals for flights from Michigan to Florence that include hotel bookings?

    Yes. In addition to deals on Michigan to Florence flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Michigan to Florence?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Michigan to Florence.

  • Can I find deals for business class flights from Michigan to Florence?

    Yes. Cheapflights offers flight deals from Michigan to Florence by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Michigan to Florence, South Carolina?

    Currently, August is the cheapest month in which you can book a flight from Michigan to Florence, South Carolina (average of $78). Flying from Michigan to Florence, South Carolina in December is currently the most expensive (average of $151). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Traveling to a place near Florence?

Book flights to Florence if you plan to visit one of these locations
Sumter
Hartsville
Darlington

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