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$211+ Cheap flights from Florence, SC (FLO) to Michigan

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 6/13. Fares are subject to change and may not be available on all flights or dates of travel.
FLO — DTW
Jun 25 — Jul 21
Thu 6/25
Thu 7/2
1 adult, Economy
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Cheap flight deals from Florence to Michigan

Cheapest flights from Florence to Michigan
Explore the most affordable flight options available from Florence to Michigan. Find the lowest fares from popular airlines and budget airlines, with prices last updated on May 26, 2026.

This American Airlines deal was found by Cheapflights users on 5/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 6/62:35 pm
FLO
-
ORD
1 stop6h 10m
American Airlines
Wed 6/104:49 pm
ORD
-
FLO
1 stop4h 11m
American Airlines
Deal found 5/22$341
This American Airlines deal was found by Cheapflights users on 5/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 6/222:35 pm
FLO
-
ORD
1 stop6h 10m
American Airlines
Mon 6/294:49 pm
ORD
-
FLO
1 stop4h 11m
American Airlines
Deal found 5/22$345
This American Airlines deal was found by Cheapflights users on 5/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/25:31 am
FLO
-
ORD
1 stop4h 53m
American Airlines
Mon 10/58:15 am
ORD
-
FLO
1 stop4h 54m
American Airlines
Deal found 5/21$379
This American Airlines deal was found by Cheapflights users on 5/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 6/52:35 pm
FLO
-
ORD
1 stop6h 10m
American Airlines
Tue 6/96:29 am
ORD
-
FLO
1 stop6h 41m
American Airlines
Deal found 5/21$409
This American Airlines deal was found by Cheapflights users on 5/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 6/82:35 pm
FLO
-
ORD
1 stop6h 10m
American Airlines
Fri 6/128:00 am
ORD
-
FLO
1 stop5h 10m
American Airlines
Deal found 5/24$441
This American Airlines deal was found by Cheapflights users on 5/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 7/125:17 am
FLO
-
DTW
1 stop4h 00m
American Airlines
Sat 7/187:58 pm
DTW
-
FLO
1 stop3h 39m
American Airlines
Deal found 5/24$518
This American Airlines deal was found by Cheapflights users on 5/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 6/52:35 pm
FLO
-
DTW
1 stop4h 43m
American Airlines
Tue 6/910:01 am
DTW
-
FLO
1 stop4h 09m
American Airlines
Deal found 5/21$619

Find flight deals from Florence to Michigan

Keep the following information in mind while searching for Florence to Michigan flight deals. Data was last updated May 26, 2026.

Most accurate provider

FlightHub
3 stars

Most trusted provider

FlightHub
3 stars

Round-trip from

$341
(American Airlines)

One-way from

$211
(American Airlines)
Provider with most accurate pricing for Florence-Detroit (DTT) flight deals.
Search Deals
Provider most trusted by Cheapflights users for Florence-Detroit (DTT) flights.
Search Deals
From Florence to Michigan
Search Deals
One-way flight from Florence to Michigan
Search Deals

Cheapflights Fare Finder

 
Customize your flight search to find flights from Florence to Michigan that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated May 26, 2026.
Use the filters below to find and compare flights from Florence to Michigan that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Cheapest round-trip

FlorenceChicago

FLO - ORD

FLOORD

Florence

Tue 6/9

2:35 pm-7:45 pm

1 stop6h 10m

Chicago O'Hare Intl

Sat 6/13

6:29 am-2:10 pm

1 stop6h 41m

$341

FlorenceChicago

FLO - ORD

FLOORD

Florence

Mon 6/22

2:35 pm-7:45 pm

1 stop6h 10m

Chicago O'Hare Intl

Mon 6/29

4:49 pm-10:00 pm

1 stop4h 11m

$345

FlorenceChicago

FLO - ORD

FLOORD

Florence

Sat 6/6

2:35 pm-7:45 pm

1 stop6h 10m

Chicago O'Hare Intl

Wed 6/10

6:29 am-2:10 pm

2 stops6h 41m

$346

FlorenceChicago

FLO - ORD

FLOORD

Florence

Fri 6/5

2:35 pm-7:45 pm

1 stop6h 10m

Chicago O'Hare Intl

Tue 6/9

6:29 am-2:10 pm

1 stop6h 41m

$409

FlorenceChicago

FLO - ORD

FLOORD

Florence

Mon 6/8

2:35 pm-7:45 pm

1 stop6h 10m

Chicago O'Hare Intl

Fri 6/12

5:00 am-2:10 pm

2 stops8h 10m

$446
Quickest round-trip

FlorenceDetroit

FLO - DTW

FLODTW

Florence

Sun 7/12

5:17 am-9:17 am

1 stop4h 00m

Detroit Metropolitan Wayne County

Sat 7/18

7:58 pm-11:37 pm

1 stop3h 39m

$518

FlorenceDetroit

FLO - DTW

FLODTW

Florence

Fri 6/5

2:35 pm-7:18 pm

1 stop4h 43m

Detroit Metropolitan Wayne County

Tue 6/9

10:01 am-2:10 pm

1 stop4h 09m

$619
Cheapest one-way
Quickest one-way

FlorenceChicago

FLO - ORD

FLOORD

Florence

Sat 6/13

2:35 pm-5:50 pm

1 stop4h 15m

$211

FlorenceChicago

FLO - ORD

FLOORD

Florence

Wed 6/10

5:05 am-9:02 am

1 stop4h 57m

$211

FlorenceChicago

FLO - ORD

FLOORD

Florence

Fri 6/12

2:35 pm-10:20 pm

2 stops8h 45m

$266

Flights are sorted by cheapest round-trip flights first.

Deals found on 5/24

Showing 1-10 of 11 resultsSorted by cheapest first
1
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Best time to book a flight from Florence to Michigan

Have a flexible travel schedule? Discover the best time to fly to Michigan from Florence with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Florence to Michigan
No data available for this route at this time. Please check back soon.

Related info for your journey

Find useful and relevant information for your journey from Florence to Michigan. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airport do you fly from for flights from Florence to Michigan?

    Florence (FLO), located 2.3 mi from the city center, is the airport you fly out of when you book flights from Florence to Michigan.

  • How long is the flight from Florence, South Carolina to Michigan?

    Airlines like American Airlines fly from Florence, South Carolina to Michigan in about 6h 10m. The time it takes to get you to your destination can typically vary by up to . Florence, South Carolina and Michigan are separated by a distance of 697 mi.

  • Can I find deals for flights from Florence to Michigan that include hotel bookings?

    Yes. In addition to deals on Florence to Michigan flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Florence to Michigan?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Florence to Michigan.

  • Can I find deals for business class flights from Florence to Michigan?

    Yes. Cheapflights offers flight deals from Florence to Michigan by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

See more FAQs

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