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$208+ Cheap flights from O'Hare Intl (ORD) to Florence, SC (FLO)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 10/7. Fares are subject to change and may not be available on all flights or dates of travel.
ORD — FLO
Oct 11 — Oct 181
Sat 10/11
Sat 10/18
1 adult, Economy
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Cheap flight deals from O'Hare Intl to Florence

Discover tips and strategies to find the most affordable flight options for your journey from O'Hare Intl (ORD) to Florence (FLO). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated September 11, 2025.

Round-trip from

$276
(American Airlines)

One-way from

$208
(American Airlines)
From Chicago O'Hare Intl to Florence
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One-way flight from Chicago O'Hare Intl to Florence
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Find flight deals from O'Hare Intl to Florence

Cheapest flights from O'Hare Intl to Florence
Explore the most affordable flight options available from O'Hare Intl to Florence. Find the lowest fares from popular airlines and budget airlines, with prices last updated on September 11, 2025.

This American Airlines deal was found by Cheapflights users on 9/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 11/195:40 pmORD - FLO
1 stop4h 13mAmerican Airlines
Wed 11/2611:11 amFLO - ORD
1 stop4h 03mAmerican Airlines
Deal found 9/10$276
This American Airlines deal was found by Cheapflights users on 9/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/275:00 amORD - FLO
1 stop4h 45mAmerican Airlines
Mon 12/86:15 amFLO - ORD
1 stop7h 17mAmerican Airlines
Deal found 9/10$303
This American Airlines deal was found by Cheapflights users on 9/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 10/195:22 amORD - FLO
1 stop4h 24mAmerican Airlines
Mon 10/202:29 pmFLO - ORD
1 stop5h 42mAmerican Airlines
Deal found 9/10$393

Cheapflights Fare Finder

 
Customize your flight search to find flights from O'Hare Intl to Florence that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated September 11, 2025.
Use the filters below to find and compare flights from Chicago O'Hare Intl Airport to Florence that are best for you.

Fly from

O'Hare Intl

Fly to

Florence

Route

Depart

Return

Price

ChicagoFlorence

ORD - FLO

ORDFLO

Chicago O'Hare Intl

Wed 11/19

5:40 pm-10:53 pm

1 stop4h 13m

Florence

Wed 11/26

11:11 am-2:14 pm

1 stop4h 03m

$276

ChicagoFlorence

ORD - FLO

ORDFLO

Chicago O'Hare Intl

Thu 11/27

5:00 am-10:45 am

1 stop4h 45m

Florence

Mon 12/8

6:15 am-12:32 pm

1 stop7h 17m

$303

ChicagoFlorence

ORD - FLO

ORDFLO

Chicago O'Hare Intl

Sun 10/19

5:22 am-10:46 am

1 stop4h 24m

Florence

Mon 10/20

2:29 pm-7:11 pm

1 stop5h 42m

$393

ChicagoFlorence

ORD - FLO

ORDFLO

Chicago O'Hare Intl

Tue 10/7

7:10 am-2:54 pm

1 stop6h 44m

$208

Flights are sorted by cheapest round-trip flights first.

Deals found on 9/9

Best time to book a flight from O'Hare Intl to Florence

Have a flexible travel schedule? Discover the best time to fly to Florence from O'Hare Intl with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Chicago O'Hare Intl Airport to Florence

What is the cheapest month to book a flight from Chicago O'Hare Intl Airport to Florence, South Carolina?

Currently, January is the cheapest month in which you can book a flight from Chicago O'Hare Intl Airport to Florence, South Carolina (average of $366). Flying from Chicago O'Hare Intl Airport to Florence, South Carolina in October is currently the most expensive (average of $501). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

Reviews of airlines servicing Florence

Get insights into the airlines that provide service to Florence. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Florence. Reviews last updated September 11, 2025.
Read reviews from past customers who have flown American Airlines from Chicago O'Hare Intl Airport to Florence. Users can see the overall rating for each airline as well as how each is rated in terms of entertainment options, comfort, food, crew/service, and boarding process.
American Airlines
7.2
Good
10,000 reviews

Comfort

7.2

Entertainment

6.9

Overall

7.2

Food

6.4

Crew

8.0

Boarding

7.5

Reviews

1 / 20
2.0
Mediocre

Jeremy,Sep 2025

SAN - PHL

Terrible. Bad customer service and unacceptable delay on the tarmac
American Airlines
7.2
Good
10,000 reviews
American Airlines
7.2
Good
10,000 reviews

Comfort

7.2

Entertainment

6.9

Overall

7.2

Food

6.4

Crew

8.0

Boarding

7.5

Reviews

1 / 20
2.0
Mediocre

Jeremy,Sep 2025

SAN - PHL

Terrible. Bad customer service and unacceptable delay on the tarmac

Related info for your journey

Find useful and relevant information for your journey from O'Hare Intl to Florence. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airport do you fly into for flights to Florence from Chicago O'Hare Intl?

    Located just 2.3 mi from the city center, Florence is the airport most travelers will use when flying to Florence from Chicago O'Hare Intl. Booking flights from Chicago O'Hare Intl to Florence (FLO) should be relatively easy as there are 0 daily inbound flights from Chicago O'Hare Intl from 1 airline.

  • How long is the flight from Chicago O'Hare Intl Airport to Florence, South Carolina?

    Airlines like American Airlines fly from Chicago O'Hare Intl Airport to Florence, South Carolina in about 4h 13m. The time it takes to get you to your destination can typically vary by up to . The distance from Chicago O'Hare Intl Airport to Florence, South Carolina is about 697 mi.

  • What is the cheapest airline to fly from Chicago O'Hare Intl Airport to Florence, South Carolina round-trip?

    Currently priced at $290, American Airlines will fly you from Chicago O'Hare Intl Airport to Florence, South Carolina and back. In addition to American Airlines, many other airlines offer competitively priced options for your trip.

  • Can I find deals for flights from O'Hare Intl to Florence that include hotel bookings?

    Yes. In addition to deals on O'Hare Intl to Florence flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from O'Hare Intl to Florence?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from O'Hare Intl to Florence.

  • Can I find deals for business class flights from O'Hare Intl to Florence?

    Yes. Cheapflights offers flight deals from O'Hare Intl to Florence by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Chicago O'Hare Intl Airport to Florence, South Carolina?

    Currently, January is the cheapest month in which you can book a flight from Chicago O'Hare Intl Airport to Florence, South Carolina (average of $366). Flying from Chicago O'Hare Intl Airport to Florence, South Carolina in October is currently the most expensive (average of $501). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Traveling to a place near Florence?

Book flights to Florence if you plan to visit one of these locations
Sumter
Hartsville
Darlington

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Top airline flying from O'Hare Intl to Florence

Discover the top airline that operate flights from O'Hare Intl to Florence. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated September 11, 2025.
AirlineCheapestAverageFlexibilityOn-time
American AirlinesCheapest$290Average$471FlexibilityNo cancel feeOn-time71%

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