HomeSearch by dateVacation packagesHotelsFlight dealsCar rentalTravel tips & news
Florence

$279+ Cheap flights from Chicago (CHI) to Florence, SC (FLO)

This is the cheapest round-trip flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 5/23. Fares are subject to change and may not be available on all flights or dates of travel.
CHI — FLO
Apr 24 — May 11
Fri 4/24
Fri 5/1
1 adult, Economy
We work with more than 300 partners to bring you better travel deals

Find cheap flights from Chicago to Florence with Cheapflights

1. Tell us where you want to go

Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”

2. Select your favorite providers

We find the providers serving your travel needs. Choose up to four travel providers to compare side-by-side for flights, hotels, or car rentals.

3. Compare prices and book

Review each provider’s pricing and select the best option for you! Book through your favorite provider’s website for a seamless experience.

Cheap flight deals from Chicago to Florence

Cheapest flights from Chicago to Florence
Explore the most affordable flight options available from Chicago to Florence. Find the lowest fares from popular airlines and budget airlines, with prices last updated on March 25, 2026.

This American Airlines deal was found by Cheapflights users on 3/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 5/234:45 pm
ORD
-
FLO
1 stop4h 15m
American Airlines
Sat 5/302:35 pm
FLO
-
ORD
1 stop6h 13m
American Airlines
Deal found 3/24$279
This American Airlines deal was found by Cheapflights users on 3/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 9/16:00 am
ORD
-
FLO
2 stops7h 09m
American Airlines
Tue 9/1511:20 am
FLO
-
ORD
1 stop5h 18m
American Airlines
Deal found 3/24$284
This American Airlines deal was found by Cheapflights users on 3/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 4/184:21 pm
ORD
-
FLO
1 stop4h 26m
American Airlines
Sat 4/255:20 am
FLO
-
ORD
1 stop4h 10m
American Airlines
Deal found 3/21$309
This American Airlines deal was found by Cheapflights users on 3/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 7/77:00 am
ORD
-
FLO
1 stop6h 10m
American Airlines
Mon 7/132:35 pm
FLO
-
ORD
1 stop6h 19m
American Airlines
Deal found 3/21$407
This American Airlines deal was found by Cheapflights users on 3/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 4/66:44 pm
ORD
-
FLO
1 stop4h 13m
American Airlines
Fri 4/105:20 am
FLO
-
ORD
1 stop6h 24m
American Airlines
Deal found 3/22$413
This American Airlines deal was found by Cheapflights users on 3/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 6/208:48 am
ORD
-
FLO
1 stop4h 22m
American Airlines
Tue 6/235:05 am
FLO
-
ORD
1 stop6h 42m
American Airlines
Deal found 3/23$474

Find flight deals from Chicago to Florence

Discover tips and strategies to find the most affordable flight options for your journey from Chicago (CHI) to Florence (FLO). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated March 25, 2026.

Most accurate provider

FlightHub
3 stars

Most trusted provider

FlightHub
3 stars

Round-trip from

$279
(American Airlines)
Provider with most accurate pricing for Chicago (CHI)-Florence flight deals.
Search Deals
Provider most trusted by Cheapflights users for Chicago (CHI)-Florence flights.
Search Deals
From Chicago (CHI) to Florence
Search Deals

Cheapflights Fare Finder

 
Customize your flight search to find flights from Chicago to Florence that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated March 25, 2026.
Use the filters below to find and compare flights from Chicago to Florence that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Cheapest round-trip

ChicagoFlorence

ORD - FLO

ORDFLO

Chicago O'Hare Intl

Tue 9/1

6:00 am-2:09 pm

2 stops7h 09m

Florence

Tue 9/15

11:20 am-3:38 pm

1 stop5h 18m

$284
Quickest round-trip

ChicagoFlorence

ORD - FLO

ORDFLO

Chicago O'Hare Intl

Sat 4/18

4:21 pm-9:47 pm

1 stop4h 26m

Florence

Sat 4/25

5:20 am-8:30 am

1 stop4h 10m

$309

ChicagoFlorence

ORD - FLO

ORDFLO

Chicago O'Hare Intl

Tue 7/7

7:00 am-2:10 pm

1 stop6h 10m

Florence

Mon 7/13

2:35 pm-7:54 pm

1 stop6h 19m

$407

ChicagoFlorence

ORD - FLO

ORDFLO

Chicago O'Hare Intl

Mon 4/6

6:44 pm-11:57 pm

1 stop4h 13m

Florence

Fri 4/10

5:20 am-10:44 am

1 stop6h 24m

$413

ChicagoFlorence

ORD - FLO

ORDFLO

Chicago O'Hare Intl

Sat 6/20

8:48 am-2:10 pm

1 stop4h 22m

Florence

Tue 6/23

5:05 am-10:47 am

1 stop6h 42m

$474

ChicagoFlorence

ORD - FLO

ORDFLO

Chicago O'Hare Intl

Sat 5/23

1:25 pm-10:00 pm

2 stops7h 35m

Florence

Sat 5/30

5:05 am-11:32 am

2 stops7h 27m

$567

Flights are sorted by cheapest round-trip flights first.

Deals found on 3/24

Sorted by cheapest first

Compare providers for flights from Chicago to Florence

Provider information is updated monthly. Please note that these providers often have deals for this flight, but the availability may vary on a day-by-day basis on Cheapflights.
Use the table below to compare price accuracy, trust ratings, and cancellation policies for each provider offering flight deals from Chicago to Florence in March.
ProviderPrice AccuracyTrust Score*
ExpediaPrice Accuracy1 starTrust Score*3 stars
FlightHubPrice Accuracy3 starsTrust Score*3 stars

*The Trust Score is based on feedback from users after their booking experience. It measures overall satisfaction, helping us identify issues like hidden fees, problems during the ticketing process, and the quality of customer service. This score is our best indicator of the provider's quality and reliability.

  • Most accurate provider: When it comes to deals on Chicago-Florence, South Carolina flights, users find the pricing of FlightHub to be most consistent on Cheapflights vs. FlightHub Users can find the same prices on Chicago-Florence, South Carolina flight deals on Cheapflights vs. FlightHub >95% of the time. Price accuracy is based on data collected from Chicago-Florence, South Carolina flight searches over the past month and is updated monthly.
  • Most trusted provider: When it comes to deals on Chicago-Florence, South Carolina flights, Cheapflights users trust FlightHub the most. FlightHub has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for Chicago-Florence, South Carolina flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.

Best time to book a flight from Chicago to Florence

Have a flexible travel schedule? Discover the best time to fly to Florence from Chicago with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Chicago to Florence

What is the cheapest month to book a flight from Chicago to Florence, South Carolina?

Currently, December is the cheapest month in which you can book a flight from Chicago to Florence, South Carolina (average of $56). Flying from Chicago to Florence, South Carolina in March is currently the most expensive (average of $108). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

Related info for your journey

Find useful and relevant information for your journey from Chicago to Florence. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airport do you fly into for flights to Florence from Chicago?

    Located just 2.3 mi from the city center, Florence is the airport most travelers will use when flying to Florence from Chicago. Booking flights from Chicago to Florence (FLO) should be relatively easy as there are 0 daily inbound flights from Chicago from 0 different airlines.

  • How long is the flight from Chicago to Florence, South Carolina?

    Departing from Chicago to Florence, South Carolina will take you 5h 59m. The distance from Chicago to Florence, South Carolina is about 697 mi.

  • Can I find deals for flights from Chicago to Florence that include hotel bookings?

    Yes. In addition to deals on Chicago to Florence flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Chicago to Florence?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Chicago to Florence.

  • Can I find deals for business class flights from Chicago to Florence?

    Yes. Cheapflights offers flight deals from Chicago to Florence by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Chicago to Florence, South Carolina?

    Currently, December is the cheapest month in which you can book a flight from Chicago to Florence, South Carolina (average of $56). Flying from Chicago to Florence, South Carolina in March is currently the most expensive (average of $108). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Traveling to a place near Florence?

Book flights to Florence if you plan to visit one of these locations
Sumter
Hartsville
Darlington

Browse thousands of different options on Cheapflights for your next trip

Toggle through the tabs below to find thousands of options on Cheapflights for your next trip.

Alternative routes for Chicago to Florence

See prices for flight routes from nearby airports that may be better suited for you.
O'Hare Intl to Charlotte flights
O'Hare Intl to Charleston flights
O'Hare Intl to Savannah flights
O'Hare Intl to Myrtle Beach flights
Midway to Charlotte flights
O'Hare Intl to Greenville flights
Midway to Savannah flights
Midway to Charleston flights
O'Hare Intl to Hilton Head Island flights
St. Louis to Charleston flights
Midway to Myrtle Beach flights
St. Louis to Charlotte flights
O'Hare Intl to Columbia flights
St. Louis to Savannah flights
St. Louis to Myrtle Beach flights
Midway to Greenville flights
Moline to Charlotte flights
Peoria to Charlotte flights
St. Louis to Columbia flights
O'Hare Intl to Augusta flights
Midway to Columbia flights
Evansville to Charleston flights
Moline to Savannah flights
Moline to Charleston flights
Peoria to Charleston flights
Moline to Myrtle Beach flights
Bloomington to Savannah flights
Peoria to Myrtle Beach flights
St. Louis to Hilton Head Island flights
Peoria to Savannah flights
St. Louis to Greenville flights
Bloomington to Charlotte flights
Evansville to Charlotte flights
Midway to Augusta flights
Moline to Columbia flights
Peoria to Greenville flights
St. Louis to Augusta flights
Peoria to Columbia flights
Bloomington to Charleston flights
Peoria to Hilton Head Island flights
Evansville to Savannah flights
Moline to Augusta flights
Moline to Greenville flights
Bloomington to Myrtle Beach flights
Springfield to Myrtle Beach flights
Springfield to Savannah flights

100% Free

Cheapflights is completely free to use, so you can start saving the moment you arrive.

Book with Flexibility

Our users can plan ahead with confidence and find flights with no change fees

Travel Smart

Millions of people come to us for their flight needs every year. We help make travel planning easy by providing useful insights and data-driven graphs that can inform your decisions.