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$393+ Cheap flights from Chicago (CHI) to Florence, SC (FLO)

This is the cheapest round-trip flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 10/17. Fares are subject to change and may not be available on all flights or dates of travel.
CHI — FLO
Oct 15 — Oct 221
Wed 10/15
Wed 10/22
1 adult, Economy
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Cheap flight deals from Chicago to Florence

Discover tips and strategies to find the most affordable flight options for your journey from Chicago (CHI) to Florence (FLO). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated September 15, 2025.

Round-trip from

$393
(American Airlines)
From Chicago (CHI) to Florence
Search Deals

Find flight deals from Chicago to Florence

Cheapest flights from Chicago to Florence
Explore the most affordable flight options available from Chicago to Florence. Find the lowest fares from popular airlines and budget airlines, with prices last updated on September 15, 2025.

This American Airlines deal was found by Cheapflights users on 9/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/275:00 amORD - FLO
1 stop4h 45mAmerican Airlines
Mon 12/86:15 amFLO - ORD
1 stop5h 27mAmerican Airlines
Deal found 9/13$393
This American Airlines deal was found by Cheapflights users on 9/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/248:35 amORD - FLO
1 stop5h 19mAmerican Airlines
Mon 10/272:29 pmFLO - ORD
1 stop5h 42mAmerican Airlines
Deal found 9/13$485
This American Airlines deal was found by Cheapflights users on 9/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/26:35 pmORD - FLO
1 stop4h 38mAmerican Airlines
Sun 10/55:14 amFLO - ORD
1 stop5h 11mAmerican Airlines
Deal found 9/14$496
This American Airlines deal was found by Cheapflights users on 9/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 9/286:35 pmORD - FLO
1 stop4h 38mAmerican Airlines
Mon 9/2912:27 pmFLO - ORD
1 stop5h 18mAmerican Airlines
Deal found 9/14$507
This American Airlines deal was found by Cheapflights users on 9/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 9/275:08 pmORD - FLO
1 stop5h 08mAmerican Airlines
Sun 9/285:14 amFLO - ORD
1 stop5h 11mAmerican Airlines
Deal found 9/14$510

Cheapflights Fare Finder

 
Customize your flight search to find flights from Chicago to Florence that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated September 15, 2025.
Use the filters below to find and compare flights from Chicago to Florence that are best for you.

Fly from

Chicago

Fly to

Florence

Route

Depart

Return

Price

ChicagoFlorence

ORD - FLO

ORDFLO

Chicago O'Hare Intl

Sun 10/19

7:10 am-2:04 pm

1 stop5h 54m

Florence

Mon 10/20

11:11 am-5:36 pm

1 stop7h 25m

$393

ChicagoFlorence

ORD - FLO

ORDFLO

Chicago O'Hare Intl

Thu 11/27

5:00 am-10:45 am

1 stop4h 45m

Florence

Mon 12/8

6:15 am-10:42 am

1 stop5h 27m

$393

ChicagoFlorence

ORD - FLO

ORDFLO

Chicago O'Hare Intl

Fri 10/17

9:10 am-2:04 pm

1 stop3h 54m

Florence

Tue 10/21

3:19 pm-7:10 pm

1 stop4h 51m

$393

ChicagoFlorence

ORD - FLO

ORDFLO

Chicago O'Hare Intl

Thu 10/23

6:36 pm-12:03 am

1 stop4h 27m

Florence

Sun 10/26

5:14 am-9:29 am

1 stop5h 15m

$393

ChicagoFlorence

ORD - FLO

ORDFLO

Chicago O'Hare Intl

Fri 10/24

8:35 am-2:54 pm

1 stop5h 19m

Florence

Mon 10/27

2:29 pm-7:11 pm

1 stop5h 42m

$485

Flights are sorted by cheapest round-trip flights first.

Deals found on 9/13

Best time to book a flight from Chicago to Florence

Have a flexible travel schedule? Discover the best time to fly to Florence from Chicago with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Chicago to Florence

What is the cheapest month to book a flight from Chicago to Florence, South Carolina?

Currently, January is the cheapest month in which you can book a flight from Chicago to Florence, South Carolina (average of $366). Flying from Chicago to Florence, South Carolina in October is currently the most expensive (average of $501). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

Related info for your journey

Find useful and relevant information for your journey from Chicago to Florence. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airport do you fly into for flights to Florence from Chicago?

    Located just 2.3 mi from the city center, Florence is the airport most travelers will use when flying to Florence from Chicago. Booking flights from Chicago to Florence (FLO) should be relatively easy as there are 0 daily inbound flights from Chicago from 1 airline.

  • How long is the flight from Chicago to Florence, South Carolina?

    Departing from Chicago to Florence, South Carolina will take you 5h 54m. The distance from Chicago to Florence, South Carolina is about 697 mi.

  • Can I find deals for flights from Chicago to Florence that include hotel bookings?

    Yes. In addition to deals on Chicago to Florence flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Chicago to Florence?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Chicago to Florence.

  • Can I find deals for business class flights from Chicago to Florence?

    Yes. Cheapflights offers flight deals from Chicago to Florence by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Chicago to Florence, South Carolina?

    Currently, January is the cheapest month in which you can book a flight from Chicago to Florence, South Carolina (average of $366). Flying from Chicago to Florence, South Carolina in October is currently the most expensive (average of $501). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Traveling to a place near Florence?

Book flights to Florence if you plan to visit one of these locations
Sumter
Hartsville
Darlington

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Alternative routes for Chicago to Florence

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Top airline flying from Chicago to Florence

Discover the top airline that operate flights from Chicago to Florence. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated September 15, 2025.
AirlineCheapestAverageFlexibilityOn-time
American AirlinesCheapest$290Average$471FlexibilityNo cancel feeOn-time71%

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