$489+ Cheap flights from Chicago (CHI) to Florence, SC (FLO)
This is the cheapest round-trip flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 10/21. Fares are subject to change and may not be available on all flights or dates of travel.
CHI — FLO
Oct 23 — Oct 301
Round-trip
1 adult, Economy
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Find cheap flights from Chicago to Florence with Cheapflights
1. Tell us where you want to go
Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”2. Select your favorite providers
We find the providers serving your travel needs. Choose up to four travel providers to compare side-by-side for flights, hotels, or car rentals.3. Compare prices and book
Review each provider’s pricing and select the best option for you! Book through your favorite provider’s website for a seamless experience.Cheap flight deals from Chicago to Florence
Cheapest
Best
Last-minute
Cheapest flights from Chicago to FlorenceExplore the most affordable flight options available from Chicago to Florence. Find the lowest fares from popular airlines and budget airlines, with prices last updated on September 23, 2026.
Explore the most affordable flight options available from Chicago to Florence. Find the lowest fares from popular airlines and budget airlines, with prices last updated on September 23, 2026.
This American Airlines deal was found by Cheapflights users on 9/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/214:45 pm -
1 stop6h 12m
Wed 10/282:34 pm -
1 stop4h 17m
Deal found 9/20![American Airlines logo]()
$489
This American Airlines deal was found by Cheapflights users on 9/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/26:29 am -
1 stop5h 49m
Mon 10/52:34 pm -
1 stop4h 17m
Deal found 9/20![American Airlines logo]()
$547
This American Airlines deal was found by Cheapflights users on 9/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 11/294:58 pm -
1 stop5h 56m
Wed 12/93:37 pm -
1 stop4h 59m
Deal found 9/21![American Airlines logo]()
$563
This American Airlines deal was found by Cheapflights users on 9/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/26:02 am -
2 stops8h 07m
Mon 12/146:24 am -
1 stop5h 36m
Deal found 9/21![American Airlines logo]()
$658
This American Airlines deal was found by Cheapflights users on 9/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 11/296:49 pm -
1 stop4h 05m
Sun 12/135:09 am -
2 stops8h 26m
Deal found 9/21![American Airlines logo]()
$723
This American Airlines deal was found by Cheapflights users on 9/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/93:37 pm -
2 stops7h 20m
Mon 10/125:09 am -
1 stop5h 01m
Deal found 9/20![American Airlines logo]()
$734
This American Airlines deal was found by Cheapflights users on 9/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 10/56:40 pm -
1 stop4h 17m
Fri 10/92:34 pm -
1 stop4h 17m
Deal found 9/20![American Airlines logo]()
$854
Best flights from Chicago to FlorenceDiscover carefully curated flight deals from Chicago to Florence that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated September 23, 2026.
Discover carefully curated flight deals from Chicago to Florence that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated September 23, 2026.
This American Airlines deal was found by Cheapflights users on 9/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/26:29 am -
1 stop5h 49m
Mon 10/52:34 pm -
1 stop4h 17m
Deal found 9/20![American Airlines logo]()
$547
This American Airlines deal was found by Cheapflights users on 9/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/98:05 am -
1 stop5h 04m
Mon 10/125:09 am -
1 stop6h 56m
Deal found 9/20![American Airlines logo]()
$547
This American Airlines deal was found by Cheapflights users on 9/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/29:00 am -
1 stop5h 09m
Fri 12/115:09 am -
1 stop6h 53m
Deal found 9/21![American Airlines logo]()
$563
This American Airlines deal was found by Cheapflights users on 9/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 11/296:49 pm -
1 stop4h 05m
Mon 12/146:24 am -
1 stop6h 55m
Deal found 9/21![American Airlines logo]()
$563
This American Airlines deal was found by Cheapflights users on 9/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/29:00 am -
1 stop5h 09m
Wed 12/96:24 am -
1 stop5h 36m
Deal found 9/21![American Airlines logo]()
$563
This American Airlines deal was found by Cheapflights users on 9/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 11/294:58 pm -
1 stop5h 56m
Sat 12/126:24 am -
1 stop6h 55m
Deal found 9/21![American Airlines logo]()
$563
This American Airlines deal was found by Cheapflights users on 9/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 11/294:58 pm -
1 stop5h 56m
Tue 12/156:24 am -
2 stops7h 35m
Deal found 9/21![American Airlines logo]()
$658
This American Airlines deal was found by Cheapflights users on 9/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/26:02 am -
2 stops8h 07m
Thu 12/102:35 pm -
1 stop6h 29m
Deal found 9/21![American Airlines logo]()
$658
This American Airlines deal was found by Cheapflights users on 9/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 10/56:40 pm -
1 stop4h 17m
Fri 10/92:34 pm -
1 stop4h 17m
Deal found 9/22![American Airlines logo]()
$864
Last-minute flights from Chicago to FlorenceDiscover last-minute flight deals from Chicago to Florence. Data last updated September 23, 2026 and is based on user searches.
Discover last-minute flight deals from Chicago to Florence. Data last updated September 23, 2026 and is based on user searches.
This American Airlines deal was found by Cheapflights users on 9/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/26:29 am -
1 stop5h 49m
Mon 10/52:34 pm -
1 stop4h 17m
Deal found 9/20![American Airlines logo]()
$547
This American Airlines deal was found by Cheapflights users on 9/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 10/56:40 pm -
1 stop4h 17m
Fri 10/92:34 pm -
1 stop4h 17m
Deal found 9/20![American Airlines logo]()
$854
This American Airlines deal was found by Cheapflights users on 9/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/93:37 pm -
2 stops7h 20m
Mon 10/125:09 am -
1 stop5h 01m
Deal found 9/20![American Airlines logo]()
$734
This American Airlines deal was found by Cheapflights users on 9/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/214:45 pm -
1 stop6h 12m
Wed 10/282:34 pm -
1 stop4h 17m
Deal found 9/20![American Airlines logo]()
$489
Find flight deals from Chicago to Florence
Discover tips and strategies to find the most affordable flight options for your journey from Chicago (CHI) to Florence (FLO). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated September 23, 2026.
Most accurate provider | FlightHub 3 stars |
|---|---|
Most trusted provider | FlightHub 3 stars |
Round-trip from | $489 (American Airlines) |
Cheapflights Fare Finder
Customize your flight search to find flights from Chicago to Florence that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 7,457,451 searches. Data last updated September 23, 2026.
Use the filters below to find and compare flights from Chicago to Florence that are best for you.
Fly from
Fly to
Route
Depart
Return
Cheapest round-trip
ChicagoFlorence
ORD Chicago O'Hare Intl - FLO Florence
ORDFLO
Chicago O'Hare Intl
Fri 10/2
6:29 am-1:18 pm
1 stop5h 49m
Florence
Mon 10/5
2:34 pm-5:51 pm
1 stop4h 17m
$547
ChicagoFlorence
ORD Chicago O'Hare Intl - FLO Florence
ORDFLO
Chicago O'Hare Intl
Fri 10/9
8:05 am-2:09 pm
1 stop5h 04m
Florence
Mon 10/12
5:09 am-11:05 am
1 stop6h 56m
$547
ChicagoFlorence
ORD Chicago O'Hare Intl - FLO Florence
ORDFLO
Chicago O'Hare Intl
Wed 12/2
9:00 am-3:09 pm
1 stop5h 09m
Florence
Fri 12/11
5:09 am-11:02 am
1 stop6h 53m
$563
ChicagoFlorence
ORD Chicago O'Hare Intl - FLO Florence
ORDFLO
Chicago O'Hare Intl
Sun 11/29
6:49 pm-11:54 pm
1 stop4h 05m
Florence
Mon 12/14
6:24 am-12:19 pm
1 stop6h 55m
$563
ChicagoFlorence
ORD Chicago O'Hare Intl - FLO Florence
ORDFLO
Chicago O'Hare Intl
Wed 12/2
9:00 am-3:09 pm
1 stop5h 09m
Florence
Wed 12/9
6:24 am-11:00 am
1 stop5h 36m
$563
ChicagoFlorence
ORD Chicago O'Hare Intl - FLO Florence
ORDFLO
Chicago O'Hare Intl
Sun 11/29
4:58 pm-11:54 pm
1 stop5h 56m
Florence
Sat 12/12
6:24 am-12:19 pm
1 stop6h 55m
$563
ChicagoFlorence
ORD Chicago O'Hare Intl - FLO Florence
ORDFLO
Chicago O'Hare Intl
Sun 11/29
4:58 pm-11:54 pm
1 stop5h 56m
Florence
Tue 12/15
6:24 am-12:59 pm
2 stops7h 35m
$658
ChicagoFlorence
ORD Chicago O'Hare Intl - FLO Florence
ORDFLO
Chicago O'Hare Intl
Wed 12/2
6:02 am-3:09 pm
2 stops8h 07m
Florence
Thu 12/10
2:35 pm-8:04 pm
1 stop6h 29m
$658
Quickest round-trip
ChicagoFlorence
ORD Chicago O'Hare Intl - FLO Florence
ORDFLO
Chicago O'Hare Intl
Mon 10/5
6:40 pm-11:57 pm
1 stop4h 17m
Florence
Fri 10/9
2:34 pm-5:51 pm
1 stop4h 17m
$864
Sorted by cheapest first
Compare providers for flights from Chicago to Florence
Provider information is updated monthly. Please note that these providers often have deals for this flight, but the availability may vary on a day-by-day basis on Cheapflights.
Use the table below to compare price accuracy, trust ratings, and cancellation policies for each provider offering flight deals from Chicago to Florence in September.
| Provider | Price Accuracy | Trust Score* |
|---|---|---|
| Price Accuracy1 star | Trust Score*3 stars | |
| Price Accuracy3 stars | Trust Score*3 stars |
- Most accurate provider: When it comes to deals on Chicago-Florence, South Carolina flights, users find the pricing of FlightHub to be most consistent on Cheapflights vs. FlightHub Users can find the same prices on Chicago-Florence, South Carolina flight deals on Cheapflights vs. FlightHub >95% of the time. Price accuracy is based on data collected from Chicago-Florence, South Carolina flight searches over the past month and is updated monthly.
- Most trusted provider: When it comes to deals on Chicago-Florence, South Carolina flights, Cheapflights users trust FlightHub the most. FlightHub has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for Chicago-Florence, South Carolina flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.
Best time to book a flight from Chicago to Florence
Have a flexible travel schedule? Discover the best time to fly to Florence from Chicago with our price prediction graph.
CHI-FLO
ORD-FLO
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.
Cheapflights Insights
Everything you need to know about your flight from Chicago to Florence
CHI-FLO
ORD-FLO
No data available for this route at this time. Please check back soon.
Related info for your journey
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