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$336+ Cheap flights from Chicago (CHI) to Florence, SC (FLO)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 12/19. Fares are subject to change and may not be available on all flights or dates of travel.
CHI — FLO
Jan 11 — Jan 181
Sun 1/11
Sun 1/18
1 adult, Economy
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Cheap flight deals from Chicago to Florence

Cheapest flights from Chicago to Florence
Explore the most affordable flight options available from Chicago to Florence. Find the lowest fares from popular airlines and budget airlines, with prices last updated on December 12, 2025.

This American Airlines deal was found by Cheapflights users on 12/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/2510:29 amORD - FLO
1 stop6h 36mAmerican Airlines
Mon 12/295:15 amFLO - ORD
1 stop6h 30mAmerican Airlines
Deal found 12/10$443
This American Airlines deal was found by Cheapflights users on 12/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/173:44 pmORD - FLO
1 stop6h 09mAmerican Airlines
Thu 12/186:30 pmFLO - ORD
1 stop6h 12mAmerican Airlines
Deal found 12/11$774

Find flight deals from Chicago to Florence

Discover tips and strategies to find the most affordable flight options for your journey from Chicago (CHI) to Florence (FLO). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated December 12, 2025.

Most accurate provider

eDreams
3 stars

Most trusted provider

eDreams
3 stars

Round-trip from

$359
(American Airlines)

One-way from

$336
(American Airlines)
Provider with most accurate pricing for Chicago (CHI)-Florence flight deals.
Search Deals
Provider most trusted by Cheapflights users for Chicago (CHI)-Florence flights.
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From Chicago (CHI) to Florence
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One-way flight from Chicago (CHI) to Florence
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Cheapflights Fare Finder

 
Customize your flight search to find flights from Chicago to Florence that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated December 12, 2025.
Use the filters below to find and compare flights from Chicago to Florence that are best for you.

Fly from

Chicago

Fly to

Florence

Route

Depart

Return

Price

ChicagoFlorence

ORD - FLO

ORDFLO

Chicago O'Hare Intl

Thu 1/8

10:10 am-5:09 pm

1 stop5h 59m

Florence

Sun 1/11

5:36 pm-11:27 pm

1 stop6h 51m

$359

ChicagoFlorence

ORD - FLO

ORDFLO

Chicago O'Hare Intl

Thu 12/25

10:29 am-6:05 pm

1 stop6h 36m

Florence

Mon 12/29

5:15 am-10:45 am

1 stop6h 30m

$443

ChicagoFlorence

ORD - FLO

ORDFLO

Chicago O'Hare Intl

Fri 12/19

10:29 am-6:05 pm

1 stop6h 36m

$336

ChicagoFlorence

ORD - FLO

ORDFLO

Chicago O'Hare Intl

Thu 12/18

5:28 pm-12:15 am

1 stop5h 47m

$336

Flights are sorted by cheapest round-trip flights first.

Deals found on 12/10

Compare providers for flights from Chicago to Florence

Provider information is updated monthly. Please note that these providers often have deals for this flight, but the availability may vary on a day-by-day basis on Cheapflights.
Use the table below to compare price accuracy, trust ratings, and cancellation policies for each provider offering flight deals from Chicago to Florence in December.
ProviderPrice AccuracyTrust Score*
ExpediaPrice Accuracy2 starsTrust Score*3 stars
FlightHubPrice Accuracy3 starsTrust Score*1 star
eDreamsPrice Accuracy3 starsTrust Score*3 stars

*The Trust Score is based on feedback from users after their booking experience. It measures overall satisfaction, helping us identify issues like hidden fees, problems during the ticketing process, and the quality of customer service. This score is our best indicator of the provider's quality and reliability.

  • Most accurate provider: When it comes to deals on Chicago-Florence, South Carolina flights, users find the pricing of eDreams to be most consistent on Cheapflights vs. eDreams Users can find the same prices on Chicago-Florence, South Carolina flight deals on Cheapflights vs. eDreams >95% of the time. Price accuracy is based on data collected from Chicago-Florence, South Carolina flight searches over the past month and is updated monthly.
  • Most trusted provider: When it comes to deals on Chicago-Florence, South Carolina flights, Cheapflights users trust eDreams the most. eDreams has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for Chicago-Florence, South Carolina flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.

Best time to book a flight from Chicago to Florence

Have a flexible travel schedule? Discover the best time to fly to Florence from Chicago with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Chicago to Florence

What is the cheapest month to book a flight from Chicago to Florence, South Carolina?

Currently, February is the cheapest month in which you can book a flight from Chicago to Florence, South Carolina (average of $51). Flying from Chicago to Florence, South Carolina in April is currently the most expensive (average of $141). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

Related info for your journey

Find useful and relevant information for your journey from Chicago to Florence. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airport do you fly into for flights to Florence from Chicago?

    Located just 2.3 mi from the city center, Florence is the airport most travelers will use when flying to Florence from Chicago. Booking flights from Chicago to Florence (FLO) should be relatively easy as there are 0 daily inbound flights from Chicago from 1 airline.

  • How long is the flight from Chicago to Florence, South Carolina?

    Departing from Chicago to Florence, South Carolina will take you 5h 59m. The distance from Chicago to Florence, South Carolina is about 697 mi.

  • Can I find deals for flights from Chicago to Florence that include hotel bookings?

    Yes. In addition to deals on Chicago to Florence flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Chicago to Florence?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Chicago to Florence.

  • Can I find deals for business class flights from Chicago to Florence?

    Yes. Cheapflights offers flight deals from Chicago to Florence by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Chicago to Florence, South Carolina?

    Currently, February is the cheapest month in which you can book a flight from Chicago to Florence, South Carolina (average of $51). Flying from Chicago to Florence, South Carolina in April is currently the most expensive (average of $141). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Traveling to a place near Florence?

Book flights to Florence if you plan to visit one of these locations
Sumter
Hartsville
Darlington

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Alternative routes for Chicago to Florence

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Top airline flying from Chicago to Florence

Discover the top airline that operate flights from Chicago to Florence. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated December 12, 2025.
AirlineCheapestAverageFlexibilityOn-time
American AirlinesCheapest$290Average$471FlexibilityNo cancel feeOn-time71%

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