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$187+ Cheap flights from Chicago (CHI) to Florence, SC (FLO)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 11/4. Fares are subject to change and may not be available on all flights or dates of travel.
CHI — FLO
Aug 12 — Aug 191
Tue 8/12
Tue 8/19
1 adult, Economy
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Cheap flight deals from Chicago to Florence

Discover tips and strategies to find the most affordable flight options for your journey from Chicago (CHI) to Florence (FLO). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated August 7, 2025.

Round-trip from

$395
(American Airlines)

One-way from

$187
(American Airlines)
From Chicago (CHI) to Florence
Search Deals
One-way flight from Chicago (CHI) to Florence
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Find flight deals from Chicago to Florence

Cheapest flights from Chicago to Florence
Explore the most affordable flight options available from Chicago to Florence. Find the lowest fares from popular airlines and budget airlines, with prices last updated on August 7, 2025.

This American Airlines deal was found by Cheapflights users on 8/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/275:00 amORD - FLO
1 stop4h 13mAmerican Airlines
Mon 12/86:55 amFLO - ORD
1 stop4h 38mAmerican Airlines
Deal found 8/6$373
This American Airlines deal was found by Cheapflights users on 8/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 8/285:20 amORD - FLO
1 stop4h 30mAmerican Airlines
Sun 8/312:34 pmFLO - ORD
1 stop3h 58mAmerican Airlines
Deal found 8/6$395
This American Airlines deal was found by Cheapflights users on 8/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 8/205:54 pmORD - FLO
1 stop4h 08mAmerican Airlines
Sun 8/245:09 amFLO - ORD
1 stop6h 34mAmerican Airlines
Deal found 8/5$417
This American Airlines deal was found by Cheapflights users on 8/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 8/166:25 pmORD - FLO
1 stop4h 34mAmerican Airlines
Sat 8/309:05 amFLO - ORD
1 stop6h 04mAmerican Airlines
Deal found 8/5$419
This American Airlines deal was found by Cheapflights users on 8/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 8/293:32 pmORD - FLO
2 stops7h 18mAmerican Airlines
Sun 8/3111:15 amFLO - ORD
2 stops7h 05mAmerican Airlines
Deal found 8/6$445

Cheapflights Fare Finder

 
Customize your flight search to find flights from Chicago to Florence that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated August 7, 2025.
Use the filters below to find and compare flights from Chicago to Florence that are best for you.

Fly from

Chicago

Fly to

Florence

Route

Depart

Return

Price

ChicagoFlorence

ORD - FLO

ORDFLO

Chicago O'Hare Intl

Thu 8/28

5:20 am-10:50 am

1 stop4h 30m

Florence

Sun 8/31

2:34 pm-5:32 pm

1 stop3h 58m

$395

ChicagoFlorence

ORD - FLO

ORDFLO

Chicago O'Hare Intl

Wed 8/20

5:54 pm-11:02 pm

1 stop4h 08m

Florence

Sun 8/24

5:09 am-10:43 am

1 stop6h 34m

$417

ChicagoFlorence

ORD - FLO

ORDFLO

Chicago O'Hare Intl

Sat 8/16

6:25 pm-11:59 pm

1 stop4h 34m

Florence

Sat 8/30

9:05 am-2:09 pm

1 stop6h 04m

$419

ChicagoFlorence

ORD - FLO

ORDFLO

Chicago O'Hare Intl

Fri 8/29

3:32 pm-11:50 pm

2 stops7h 18m

Florence

Sun 8/31

11:15 am-5:20 pm

2 stops7h 05m

$445

ChicagoFlorence

ORD - FLO

ORDFLO

Chicago O'Hare Intl

Tue 11/4

5:00 am-10:41 am

1 stop4h 41m

$187

ChicagoFlorence

ORD - FLO

ORDFLO

Chicago O'Hare Intl

Tue 8/12

7:35 am-3:04 pm

1 stop6h 29m

$311

ChicagoFlorence

ORD - FLO

ORDFLO

Chicago O'Hare Intl

Mon 8/11

6:03 am-11:46 am

1 stop4h 43m

$429

Flights are sorted by cheapest round-trip flights first.

Deals found on 8/5

Best time to book a flight from Chicago to Florence

Have a flexible travel schedule? Discover the best time to fly to Florence from Chicago with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Chicago to Florence

What is the cheapest month to book a flight from Chicago to Florence, South Carolina?

Currently, January is the cheapest month in which you can book a flight from Chicago to Florence, South Carolina (average of $366). Flying from Chicago to Florence, South Carolina in October is currently the most expensive (average of $487). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

Reviews of airlines servicing Florence

Get insights into the airlines that provide service to Florence. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Florence. Reviews last updated August 7, 2025.
Peruse reviews from past customers who have flown with American Airlines from Chicago to Florence to help guide your decision. You can also see how each airline stacks up in terms of entertainment options, comfort, food, crew/service, and boarding process.
American Airlines
7.2
Good
10,000 reviews

Crew

8.0

Comfort

7.2

Boarding

7.5

Entertainment

6.9

Food

6.5

Overall

7.2

Reviews

1 / 20
2.0
Mediocre

Andrew,May 2025

LAX - MIA

2 hour delay. Discovered an engine problem late, we boarded the plane and they asked us to come off. To add insult to injury nothing was given to passengers to make amends. No free drink. No extra food or snacks. No free WiFi. Gimme a break
American Airlines
7.2
Good
10,000 reviews
American Airlines
7.2
Good
10,000 reviews

Crew

8.0

Comfort

7.2

Boarding

7.5

Entertainment

6.9

Food

6.5

Overall

7.2

Reviews

1 / 20
2.0
Mediocre

Andrew,May 2025

LAX - MIA

2 hour delay. Discovered an engine problem late, we boarded the plane and they asked us to come off. To add insult to injury nothing was given to passengers to make amends. No free drink. No extra food or snacks. No free WiFi. Gimme a break

Related info for your journey

Find useful and relevant information for your journey from Chicago to Florence. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airport do you fly into for flights to Florence from Chicago?

    Located just 2.3 mi from the city center, Florence is the airport most travelers will use when flying to Florence from Chicago. Booking flights from Chicago to Florence (FLO) should be relatively easy as there are 0 daily inbound flights from Chicago from 1 airline.

  • Can I find deals for flights from Chicago to Florence that include hotel bookings?

    Yes. In addition to deals on Chicago to Florence flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Chicago to Florence?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Chicago to Florence.

  • Can I find deals for business class flights from Chicago to Florence?

    Yes. Cheapflights offers flight deals from Chicago to Florence by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Chicago to Florence, South Carolina?

    Currently, January is the cheapest month in which you can book a flight from Chicago to Florence, South Carolina (average of $366). Flying from Chicago to Florence, South Carolina in October is currently the most expensive (average of $487). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Traveling to a place near Florence?

Book flights to Florence if you plan to visit one of these locations
Sumter
Hartsville
Darlington

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Top airline flying from Chicago to Florence

Discover the top airline that operate flights from Chicago to Florence. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated August 7, 2025.
AirlineCheapestAverageFlexibilityOn-time
American AirlinesCheapest$290Average$461FlexibilityNo cancel feeOn-time71%

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