To save up to 65% on this flight, we recommend booking at least 32 days prior to travel. The price may fluctuate and will likely increase closer to your departure date. Users on Cheapflights have found tickets from Key West to Florence from $349 1-2 weeks out and tickets from $383 for flights departing within the next 72 hours.
Flights from Key West to Florence lean towards being more expensive in November. Prices are generally better when you fly from Key West to Florence in August, with the cheapest ticket starting at $108.