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Durham

$114+ Cheap flights from Knoxville (TYS) to Durham, NC

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 10/3. Fares are subject to change and may not be available on all flights or dates of travel.
TYS — RDU
Aug 30 — Sep 61
Sun 8/30
Sun 9/6
1 adult, Economy
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Cheap flight deals from Knoxville to Durham

Cheapest flights from Knoxville to Durham
Explore the most affordable flight options available from Knoxville to Durham. Find the lowest fares from popular airlines and budget airlines, with prices last updated on July 31, 2026.

This Kiwi.com deal was found by Cheapflights users on 7/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 8/208:00 am
TYS
-
RDU
1 stop10h 15m
Multiple Airlines
Mon 8/249:59 pm
RDU
-
TYS
1 stop16h 36m
Multiple Airlines
Deal found 7/28$171
This Kiwi.com deal was found by Cheapflights users on 7/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 8/2012:55 pm
TYS
-
RDU
2 stops11h 04m
Multiple Airlines
Sun 8/239:59 pm
RDU
-
TYS
1 stop21h 06m
Multiple Airlines
Deal found 7/31$202
This Kiwi.com deal was found by Cheapflights users on 7/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 8/286:27 pm
TYS
-
RDU
1 stop15h 25m
Multiple Airlines
Mon 8/319:13 am
RDU
-
TYS
1 stop9h 13m
Multiple Airlines
Deal found 7/27$204
This Kiwi.com deal was found by Cheapflights users on 7/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 8/242:51 pm
TYS
-
RDU
1 stop19h 01m
Multiple Airlines
Mon 8/319:13 am
RDU
-
TYS
1 stop9h 50m
Multiple Airlines
Deal found 7/27$213
This Kiwi.com deal was found by Cheapflights users on 7/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 8/278:00 am
TYS
-
RDU
1 stop10h 15m
Multiple Airlines
Sat 8/295:55 pm
RDU
-
TYS
1 stop16h 50m
Multiple Airlines
Deal found 7/27$215
This Kiwi.com deal was found by Cheapflights users on 7/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 9/241:19 pm
TYS
-
RDU
2 stops11h 10m
Multiple Airlines
Sun 9/2710:00 am
RDU
-
TYS
1 stop6h 48m
Multiple Airlines
Deal found 7/28$217
This Kiwi.com deal was found by Cheapflights users on 7/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 8/286:27 pm
TYS
-
RDU
1 stop15h 25m
Multiple Airlines
Sat 8/299:48 pm
RDU
-
TYS
1 stop12h 57m
Multiple Airlines
Deal found 7/27$220
This Kiwi.com deal was found by Cheapflights users on 7/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 8/274:52 pm
TYS
-
RDU
2 stops17h 27m
Multiple Airlines
Sun 8/309:59 pm
RDU
-
TYS
1 stop21h 04m
Multiple Airlines
Deal found 7/27$223
This Kiwi.com deal was found by Cheapflights users on 7/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 8/212:51 pm
TYS
-
RDU
1 stop19h 01m
Multiple Airlines
Mon 8/249:13 am
RDU
-
TYS
1 stop9h 52m
Multiple Airlines
Deal found 7/31$226

Find flight deals from Knoxville to Durham

Keep the following information in mind while searching for Knoxville to Durham flight deals. Data was last updated July 31, 2026.

Most accurate provider

FlightHub
3 stars

Most trusted provider

FlightHub
3 stars

Round-trip from

$171
(Kiwi.com)

One-way from

$114
(Kiwi.com)

Popular in

February

Cheapest in

May

Average price

$674
Provider with most accurate pricing for Knoxville McGhee Tyson-Raleigh-Durham flight deals.
Search Deals
Provider most trusted by Cheapflights users for Knoxville McGhee Tyson-Raleigh-Durham flights.
Search Deals
From Knoxville McGhee Tyson to Durham
Search Deals
One-way flight from Knoxville McGhee Tyson to Durham
Search Deals
Highest demand for flights based on searches. 16% potential increase in price ($94 potential increase over avg. RT price).
Search Deals
Cheapest flight prices on average. 6% potential price decrease ($28 potential savings vs. average RT price).
Search Deals
Average for round-trip flights in July 2026
Search Deals

Cheapflights Fare Finder

 
Customize your flight search to find flights from Knoxville to Durham that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated July 31, 2026.
Use the filters below to find and compare flights from Knoxville to Durham that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Cheapest round-trip

KnoxvilleRaleigh

TYS - RDU

TYSRDU

Knoxville McGhee Tyson

Wed 8/26

12:01 pm-4:03 pm

1 stop4h 02m

Raleigh-Durham

Wed 9/2

7:30 am-11:11 am

1 stop3h 41m

$233
Quickest round-trip

KnoxvilleRaleigh

TYS - RDU

TYSRDU

Knoxville McGhee Tyson

Thu 8/27

10:28 am-2:20 pm

1 stop3h 52m

Raleigh-Durham

Thu 9/3

6:15 am-9:36 am

1 stop3h 21m

$233

KnoxvilleRaleigh

TYS - RDU

TYSRDU

Knoxville McGhee Tyson

Thu 8/20

7:30 am-11:46 am

1 stop4h 16m

Raleigh-Durham

Mon 8/24

6:15 pm-11:52 pm

1 stop5h 37m

$233

KnoxvilleRaleigh

TYS - RDU

TYSRDU

Knoxville McGhee Tyson

Tue 9/8

7:50 am-2:16 pm

1 stop6h 26m

Raleigh-Durham

Tue 9/15

1:42 pm-6:57 pm

1 stop5h 15m

$233

KnoxvilleRaleigh

TYS - RDU

TYSRDU

Knoxville McGhee Tyson

Fri 9/18

1:54 pm-9:10 pm

1 stop7h 16m

Raleigh-Durham

Sun 9/20

9:35 pm-8:39 pm

1 stop23h 04m

$242

KnoxvilleRaleigh

TYS - RDU

TYSRDU

Knoxville McGhee Tyson

Wed 8/26

10:28 am-2:20 pm

1 stop3h 52m

Raleigh-Durham

Fri 8/28

5:10 am-11:11 am

1 stop6h 01m

$271

KnoxvilleRaleigh

TYS - RDU

TYSRDU

Knoxville McGhee Tyson

Wed 8/26

7:00 am-2:55 pm

2 stops7h 55m

Raleigh-Durham

Fri 8/28

12:30 pm-6:35 pm

2 stops6h 05m

$281

KnoxvilleRaleigh

TYS - RDU

TYSRDU

Knoxville McGhee Tyson

Tue 9/8

7:00 am-5:35 pm

2 stops10h 35m

Raleigh-Durham

Tue 9/15

6:45 am-12:05 pm

1 stop5h 20m

$291

KnoxvilleRaleigh

TYS - RDU

TYSRDU

Knoxville McGhee Tyson

Fri 8/28

7:10 am-6:50 pm

2 stops11h 40m

Raleigh-Durham

Sat 8/29

6:40 am-5:40 pm

2 stops11h 00m

$293

KnoxvilleRaleigh

TYS - RDU

TYSRDU

Knoxville McGhee Tyson

Fri 8/28

7:10 am-6:50 pm

2 stops11h 40m

Raleigh-Durham

Mon 8/31

12:30 pm-6:35 pm

2 stops6h 05m

$344

Flights are sorted by cheapest round-trip flights first.

Deals found on 7/31

Showing 1-10 of 17 resultsSorted by cheapest first
1
2

Best time to book a flight from Knoxville to Durham

Have a flexible travel schedule? Discover the best time to fly to Durham from Knoxville with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Knoxville to Durham

How much does it cost to fly round-trip from Knoxville to Durham?

Airfare is below average for this route at the moment.
Knoxville to Durham flights typically cost between $258 and $591 in August.
The cheapest round-trip price found within the last 5 days was $171 on Multiple Airlines (Aug 20-Aug 24).

Reviews of airlines servicing Durham

Get insights into the airlines that provide service to Durham. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Durham. Reviews last updated July 31, 2026.
Read reviews from past customers who have flown Delta and American Airlines from Knoxville to Durham. Users can see the overall rating for each airline as well as how each is rated in terms of entertainment options, comfort, food, crew/service, and boarding process.
Delta
7.8
Good
8,494 reviews

Entertainment

7.8

Comfort

7.8

Food

7.2

Crew

8.5

Boarding

8.1

Overall

7.8

Reviews

1 / 20
8.0
Excellent

Lane,Nov 2025

MEM - ATL

The crew was very friendly, but they only came around and offered the better Delta Comfort snacks one time. I thought they would come around more frequently on a 5 hour flight. They did do two beverage services though, which was nice.
Delta
7.8
Good
8,494 reviews
Delta
7.8
Good
8,494 reviews

Entertainment

7.8

Comfort

7.8

Food

7.2

Crew

8.5

Boarding

8.1

Overall

7.8

Reviews

1 / 20
8.0
Excellent

Lane,Nov 2025

MEM - ATL

The crew was very friendly, but they only came around and offered the better Delta Comfort snacks one time. I thought they would come around more frequently on a 5 hour flight. They did do two beverage services though, which was nice.
American Airlines
7.1
Good
11,846 reviews
Delta
7.8
Good
8,494 reviews

Entertainment

7.8

Comfort

7.8

Food

7.2

Crew

8.5

Boarding

8.1

Overall

7.8

Reviews

1 / 20
8.0
Excellent

Lane,Nov 2025

MEM - ATL

The crew was very friendly, but they only came around and offered the better Delta Comfort snacks one time. I thought they would come around more frequently on a 5 hour flight. They did do two beverage services though, which was nice.

Related info for your journey

Find useful and relevant information for your journey from Knoxville to Durham. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airport do you fly from for flights from Knoxville to Durham?

    Knoxville McGhee Tyson (TYS) is the airport you will fly out of if you book a flight from Knoxville to Durham. You should not have trouble finding flights to Durham from McGhee Tyson; the airport handles an average of 0 outbound flights to Durham per day. You should also have plenty of airline options to choose from since 2 airlines have flights from the Knoxville airport to Durham. It is only a 11.3 mi journey to McGhee Tyson (TYS) from Knoxville’s city center.

  • How long is the flight from Knoxville to Durham?

    Departing from Knoxville to Durham will take you 4h 02m. The distance between Knoxville and Durham is about 291 mi.

  • Can I find deals for flights from Knoxville to Durham that include hotel bookings?

    Yes. In addition to deals on Knoxville to Durham flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Knoxville to Durham?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Knoxville to Durham.

  • Can I find deals for business class flights from Knoxville to Durham?

    Yes. Cheapflights offers flight deals from Knoxville to Durham by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

See more FAQs

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Top 2 airlines flying from Knoxville to Durham

Discover the top 2 airlines that operate flights from Knoxville to Durham. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated July 31, 2026.
AirlineCheapestAverageFlexibilityOn-time
American AirlinesCheapest$258Average$427FlexibilityNo cancel feeOn-time71%
DeltaCheapest$327Average$526FlexibilityNo cancel feeOn-timeN/A

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