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$124+ Cheap flights from Knoxville (TYS) to Durham, NC

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 7/27. Fares are subject to change and may not be available on all flights or dates of travel.
TYS — RDU
Jul 16 — Jul 231
Thu 7/16
Thu 7/23
1 adult, Economy
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Cheap flight deals from Knoxville to Durham

Cheapest flights from Knoxville to Durham
Explore the most affordable flight options available from Knoxville to Durham. Find the lowest fares from popular airlines and budget airlines, with prices last updated on June 16, 2026.

This Kiwi.com deal was found by Cheapflights users on 6/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 8/133:56 pm
TYS
-
RDU
1 stop17h 04m
Multiple Airlines
Sun 8/169:03 pm
RDU
-
TYS
1 stop23h 15m
Multiple Airlines
Deal found 6/13$184
This Kiwi.com deal was found by Cheapflights users on 6/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 7/1012:40 pm
TYS
-
RDU
2 stops11h 24m
Multiple Airlines
Mon 7/132:31 pm
RDU
-
TYS
1 stop9h 02m
Multiple Airlines
Deal found 6/14$223
This Southwest deal was found by Cheapflights users on 6/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 10/267:20 pm
TYS
-
RDU
1 stop3h 35m
Southwest
Tue 10/276:40 am
RDU
-
TYS
1 stop5h 25m
Southwest
Deal found 6/11$244
This Kiwi.com deal was found by Cheapflights users on 6/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 8/37:20 pm
TYS
-
RDU
1 stop14h 05m
Multiple Airlines
Fri 8/710:59 am
RDU
-
TYS
2 stops23h 27m
Multiple Airlines
Deal found 6/14$250
This Kiwi.com deal was found by Cheapflights users on 6/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 7/267:15 am
TYS
-
RDU
1 stop9h 54m
Multiple Airlines
Mon 7/272:31 pm
RDU
-
TYS
1 stop9h 02m
Multiple Airlines
Deal found 6/14$255
This Kiwi.com deal was found by Cheapflights users on 6/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 7/37:20 pm
TYS
-
RDU
1 stop13h 40m
Multiple Airlines
Tue 7/711:55 am
RDU
-
TYS
2 stops30h 04m
Multiple Airlines
Deal found 6/14$277

Find flight deals from Knoxville to Durham

Keep the following information in mind while searching for Knoxville to Durham flight deals. Data was last updated June 16, 2026.

Most accurate provider

FlightHub
3 stars

Most trusted provider

FlightHub
3 stars

Round-trip from

$184
(Kiwi.com)

One-way from

$124
(Kiwi.com)

Popular in

February

Cheapest in

August

Average price

$342
Provider with most accurate pricing for Knoxville McGhee Tyson-Raleigh-Durham flight deals.
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Provider most trusted by Cheapflights users for Knoxville McGhee Tyson-Raleigh-Durham flights.
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From Knoxville McGhee Tyson to Durham
Search Deals
One-way flight from Knoxville McGhee Tyson to Durham
Search Deals
Highest demand for flights based on searches. 24% potential increase in price ($142 potential increase over avg. RT price).
Search Deals
Cheapest flight prices on average. 7% potential price decrease ($32 potential savings vs. average RT price).
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Average for round-trip flights in June 2026
Search Deals

Cheapflights Fare Finder

 
Customize your flight search to find flights from Knoxville to Durham that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated June 16, 2026.
Use the filters below to find and compare flights from Knoxville to Durham that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Cheapest round-trip

KnoxvilleRaleigh

TYS - RDU

TYSRDU

Knoxville McGhee Tyson

Thu 8/13

3:56 pm-9:00 am

1 stop17h 04m

Raleigh-Durham

Sun 8/16

9:03 pm-8:18 pm

1 stop23h 15m

$184

KnoxvilleRaleigh

TYS - RDU

TYSRDU

Knoxville McGhee Tyson

Mon 10/26

7:20 pm-10:55 pm

1 stop3h 35m

Raleigh-Durham

Tue 10/27

6:40 am-12:05 pm

1 stop5h 25m

$244

KnoxvilleRaleigh

TYS - RDU

TYSRDU

Knoxville McGhee Tyson

Thu 8/13

7:10 am-3:45 pm

2 stops8h 35m

Raleigh-Durham

Sun 8/16

10:50 am-8:45 pm

2 stops9h 55m

$319

KnoxvilleRaleigh

TYS - RDU

TYSRDU

Knoxville McGhee Tyson

Tue 7/7

6:55 pm-10:20 pm

1 stop3h 25m

Raleigh-Durham

Mon 7/13

7:15 am-1:45 pm

1 stop6h 30m

$321
Quickest round-trip

KnoxvilleRaleigh

TYS - RDU

TYSRDU

Knoxville McGhee Tyson

Fri 7/17

5:00 am-8:04 am

1 stop3h 04m

Raleigh-Durham

Sun 7/19

6:29 pm-10:23 pm

1 stop3h 54m

$337

KnoxvilleRaleigh

TYS - RDU

TYSRDU

Knoxville McGhee Tyson

Thu 10/1

7:20 pm-9:50 am

2 stops14h 30m

Raleigh-Durham

Tue 10/6

8:30 am-6:30 pm

2 stops10h 00m

$359

KnoxvilleRaleigh

TYS - RDU

TYSRDU

Knoxville McGhee Tyson

Fri 10/2

7:10 am-9:30 pm

2 stops14h 20m

Raleigh-Durham

Tue 10/6

6:10 am-6:30 pm

2 stops12h 20m

$372

KnoxvilleRaleigh

TYS - RDU

TYSRDU

Knoxville McGhee Tyson

Mon 11/23

5:57 pm-12:23 am

1 stop6h 26m

Raleigh-Durham

Sun 11/29

7:58 pm-11:46 pm

1 stop3h 48m

$386

KnoxvilleRaleigh

TYS - RDU

TYSRDU

Knoxville McGhee Tyson

Fri 7/10

6:40 am-5:30 pm

2 stops10h 50m

Raleigh-Durham

Mon 7/13

8:40 am-9:15 pm

2 stops12h 35m

$399
Cheapest one-way

KnoxvilleRaleigh

TYS - RDU

TYSRDU

Knoxville McGhee Tyson

Wed 7/15

1:05 pm-9:45 am

2 stops20h 40m

$128

Flights are sorted by cheapest round-trip flights first.

Deals found on 6/15

Showing 1-10 of 14 resultsSorted by cheapest first
1
2

Best time to book a flight from Knoxville to Durham

Have a flexible travel schedule? Discover the best time to fly to Durham from Knoxville with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Knoxville to Durham

How much does it cost to fly round-trip from Knoxville to Durham?

Reviews of airlines servicing Durham

Get insights into the airlines that provide service to Durham. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Durham. Reviews last updated June 16, 2026.
Read reviews from past customers who have flown Delta and American Airlines from Knoxville to Durham. Users can see the overall rating for each airline as well as how each is rated in terms of entertainment options, comfort, food, crew/service, and boarding process.
Delta
7.9
Good
8,405 reviews

Entertainment

7.8

Boarding

8.1

Crew

8.5

Food

7.2

Comfort

7.8

Overall

7.9

Reviews

1 / 20
10.0
Excellent

Anonymous,May 2026

SEA - KOA

The snacks were not very good, not everyone was very friendly and professional
Delta
7.9
Good
8,405 reviews
Delta
7.9
Good
8,405 reviews

Entertainment

7.8

Boarding

8.1

Crew

8.5

Food

7.2

Comfort

7.8

Overall

7.9

Reviews

1 / 20
10.0
Excellent

Anonymous,May 2026

SEA - KOA

The snacks were not very good, not everyone was very friendly and professional
American Airlines
7.1
Good
11,665 reviews
Delta
7.9
Good
8,405 reviews

Entertainment

7.8

Boarding

8.1

Crew

8.5

Food

7.2

Comfort

7.8

Overall

7.9

Reviews

1 / 20
10.0
Excellent

Anonymous,May 2026

SEA - KOA

The snacks were not very good, not everyone was very friendly and professional

Related info for your journey

Find useful and relevant information for your journey from Knoxville to Durham. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airport do you fly from for flights from Knoxville to Durham?

    Knoxville McGhee Tyson (TYS) is the airport you will fly out of if you book a flight from Knoxville to Durham. You should not have trouble finding flights to Durham from McGhee Tyson; the airport handles an average of 0 outbound flights to Durham per day. You should also have plenty of airline options to choose from since 2 airlines have flights from the Knoxville airport to Durham. It is only a 11.3 mi journey to McGhee Tyson (TYS) from Knoxville’s city center.

  • How long is the flight from Knoxville to Durham?

    Departing from Knoxville to Durham will take you 3h 35m. The distance between Knoxville and Durham is about 291 mi.

  • Can I find deals for flights from Knoxville to Durham that include hotel bookings?

    Yes. In addition to deals on Knoxville to Durham flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Knoxville to Durham?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Knoxville to Durham.

  • Can I find deals for business class flights from Knoxville to Durham?

    Yes. Cheapflights offers flight deals from Knoxville to Durham by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

See more FAQs

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Top 2 airlines flying from Knoxville to Durham

Discover the top 2 airlines that operate flights from Knoxville to Durham. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated June 16, 2026.
AirlineCheapestAverageFlexibilityOn-time
American AirlinesCheapest$218Average$357FlexibilityNo cancel feeOn-time71%
DeltaCheapest$218Average$427FlexibilityNo cancel feeOn-timeN/A

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