$103+ Cheap flights from Knoxville (TYS) to Durham, NC
This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 5/29. Fares are subject to change and may not be available on all flights or dates of travel.
TYS — RDU
May 31 — Jun 71
Round-trip
1 adult, Economy
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Find cheap flights from Knoxville to Durham with Cheapflights
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Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”2. Select your favorite providers
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Review each provider’s pricing and select the best option for you! Book through your favorite provider’s website for a seamless experience.Cheap flight deals from Knoxville to Durham
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Cheapest flights from Knoxville to DurhamExplore the most affordable flight options available from Knoxville to Durham. Find the lowest fares from popular airlines and budget airlines, with prices last updated on May 1, 2026.
Explore the most affordable flight options available from Knoxville to Durham. Find the lowest fares from popular airlines and budget airlines, with prices last updated on May 1, 2026.
This Kiwi.com deal was found by Cheapflights users on 4/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 5/272:20 pm
TYS
- RDU
1 stop19h 01m
Multiple Airlines
Wed 6/37:52 pm
RDU
- TYS
1 stop26h 37m
Multiple Airlines
Deal found 4/29![Multiple Airlines logo]()
$197
This Kiwi.com deal was found by Cheapflights users on 4/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 5/2910:03 pm
TYS
- RDU
1 stop10h 57m
Multiple Airlines
Mon 6/112:33 pm
RDU
- TYS
2 stops9h 28m
Multiple Airlines
Deal found 4/28![Multiple Airlines logo]()
$199
This Kiwi.com deal was found by Cheapflights users on 4/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 5/111:15 pm
TYS
- RDU
1 stop20h 45m
Multiple Airlines
Fri 5/1511:47 am
RDU
- TYS
1 stop23h 19m
Multiple Airlines
Deal found 4/26![Multiple Airlines logo]()
$216
This Kiwi.com deal was found by Cheapflights users on 4/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 6/812:40 pm
TYS
- RDU
2 stops11h 44m
Multiple Airlines
Tue 6/99:40 am
RDU
- TYS
1 stop6h 32m
Multiple Airlines
Deal found 4/26![Multiple Airlines logo]()
$218
This Kiwi.com deal was found by Cheapflights users on 4/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 5/111:15 pm
TYS
- RDU
1 stop20h 06m
Multiple Airlines
Thu 5/1411:47 am
RDU
- TYS
1 stop9h 03m
Multiple Airlines
Deal found 4/27![Multiple Airlines logo]()
$224
This Kiwi.com deal was found by Cheapflights users on 4/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 5/271:01 pm
TYS
- RDU
1 stop21h 51m
Multiple Airlines
Sun 5/3112:54 pm
RDU
- TYS
2 stops27h 46m
Multiple Airlines
Deal found 4/27![Multiple Airlines logo]()
$235
This Kiwi.com deal was found by Cheapflights users on 4/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 5/228:19 pm
TYS
- RDU
1 stop15h 12m
Multiple Airlines
Mon 5/252:32 pm
RDU
- TYS
1 stop9h 05m
Multiple Airlines
Deal found 4/27![Multiple Airlines logo]()
$255
This Kiwi.com deal was found by Cheapflights users on 4/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 6/127:10 am
TYS
- RDU
1 stop10h 30m
Multiple Airlines
Sun 6/1410:22 pm
RDU
- TYS
1 stop25h 12m
Multiple Airlines
Deal found 4/29![Multiple Airlines logo]()
$262
Best flights from Knoxville to DurhamDiscover carefully curated flight deals from Knoxville to Durham that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated May 1, 2026.
Discover carefully curated flight deals from Knoxville to Durham that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated May 1, 2026.
This Kiwi.com deal was found by Cheapflights users on 4/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 5/272:20 pm
TYS
- RDU
1 stop19h 01m
Multiple Airlines
Wed 6/37:52 pm
RDU
- TYS
1 stop26h 37m
Multiple Airlines
Deal found 4/29![Multiple Airlines logo]()
$197
This Southwest deal was found by Cheapflights users on 4/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 6/156:40 am
TYS
- RDU
1 stop6h 00m
Southwest
Tue 6/164:10 pm
RDU
- TYS
1 stop4h 10m
Southwest
Deal found 4/26![Southwest logo]()
$308
This Kiwi.com deal was found by Cheapflights users on 4/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 5/2910:03 pm
TYS
- RDU
1 stop10h 57m
Multiple Airlines
Mon 6/12:32 pm
RDU
- TYS
1 stop9h 05m
Multiple Airlines
Deal found 4/28![Multiple Airlines logo]()
$212
This Kiwi.com deal was found by Cheapflights users on 4/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 5/271:01 pm
TYS
- RDU
1 stop21h 51m
Multiple Airlines
Sun 5/3112:54 pm
RDU
- TYS
2 stops27h 46m
Multiple Airlines
Deal found 4/27![Multiple Airlines logo]()
$235
This United Airlines deal was found by Cheapflights users on 4/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 6/45:45 am
TYS
- RDU
1 stop17h 44m
United Airlines
Mon 6/86:15 am
RDU
- TYS
1 stop18h 15m
United Airlines
Deal found 4/28![United Airlines logo]()
$582
This Kiwi.com deal was found by Cheapflights users on 4/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 6/77:15 am
TYS
- RDU
1 stop7h 07m
Multiple Airlines
Wed 6/107:45 pm
RDU
- TYS
1 stop24h 45m
Multiple Airlines
Deal found 4/30![Multiple Airlines logo]()
$283
This Southwest deal was found by Cheapflights users on 4/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 5/226:35 am
TYS
- RDU
2 stops11h 55m
Southwest
Mon 5/252:00 pm
RDU
- TYS
2 stops6h 20m
Southwest
Deal found 4/27![Southwest logo]()
$362
This Kiwi.com deal was found by Cheapflights users on 4/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 5/111:15 pm
TYS
- RDU
1 stop20h 06m
Multiple Airlines
Thu 5/1412:53 pm
RDU
- TYS
2 stops23h 32m
Multiple Airlines
Deal found 4/27![Multiple Airlines logo]()
$304
This Southwest deal was found by Cheapflights users on 4/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 5/277:05 am
TYS
- RDU
2 stops9h 25m
Southwest
Wed 6/39:50 am
RDU
- TYS
2 stops9h 50m
Southwest
Deal found 4/29![Southwest logo]()
$378
This Southwest deal was found by Cheapflights users on 4/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 6/86:40 am
TYS
- RDU
2 stops12h 15m
Southwest
Tue 6/911:15 am
RDU
- TYS
2 stops9h 05m
Southwest
Deal found 4/26![Southwest logo]()
$393
This Southwest deal was found by Cheapflights users on 4/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 5/127:05 am
TYS
- RDU
1 stop5h 40m
Southwest
Wed 5/136:40 am
RDU
- TYS
1 stop5h 20m
Southwest
Deal found 4/27![Southwest logo]()
$437
Last-minute flights from Knoxville to DurhamDiscover last-minute flight deals from Knoxville to Durham. Data last updated May 1, 2026 and is based on user searches.
Discover last-minute flight deals from Knoxville to Durham. Data last updated May 1, 2026 and is based on user searches.
This Kiwi.com deal was found by Cheapflights users on 4/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 5/78:20 am
TYS
- RDU
1 stop9h 16m
Multiple Airlines
Sat 5/910:03 pm
RDU
- TYS
1 stop24h 30m
Multiple Airlines
Deal found 4/27![Multiple Airlines logo]()
$281
This Kiwi.com deal was found by Cheapflights users on 4/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 5/111:15 pm
TYS
- RDU
1 stop20h 45m
Multiple Airlines
Fri 5/1511:47 am
RDU
- TYS
1 stop23h 19m
Multiple Airlines
Deal found 4/26![Multiple Airlines logo]()
$216
This Kiwi.com deal was found by Cheapflights users on 4/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 5/111:15 pm
TYS
- RDU
1 stop20h 06m
Multiple Airlines
Thu 5/1411:47 am
RDU
- TYS
1 stop9h 03m
Multiple Airlines
Deal found 4/27![Multiple Airlines logo]()
$224
This Kiwi.com deal was found by Cheapflights users on 4/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 5/1712:55 pm
TYS
- RDU
1 stop9h 48m
Multiple Airlines
Wed 5/2012:33 pm
RDU
- TYS
2 stops23h 40m
Multiple Airlines
Deal found 4/29![Multiple Airlines logo]()
$275
This Kiwi.com deal was found by Cheapflights users on 4/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 5/228:19 pm
TYS
- RDU
1 stop15h 12m
Multiple Airlines
Mon 5/252:32 pm
RDU
- TYS
1 stop9h 05m
Multiple Airlines
Deal found 4/27![Multiple Airlines logo]()
$255
This Kiwi.com deal was found by Cheapflights users on 4/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 5/272:20 pm
TYS
- RDU
1 stop19h 01m
Multiple Airlines
Wed 6/37:52 pm
RDU
- TYS
1 stop26h 37m
Multiple Airlines
Deal found 4/29![Multiple Airlines logo]()
$197
This Kiwi.com deal was found by Cheapflights users on 4/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 5/271:01 pm
TYS
- RDU
1 stop21h 51m
Multiple Airlines
Sun 5/3112:54 pm
RDU
- TYS
2 stops27h 46m
Multiple Airlines
Deal found 4/27![Multiple Airlines logo]()
$235
This Kiwi.com deal was found by Cheapflights users on 4/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 5/2910:03 pm
TYS
- RDU
1 stop10h 57m
Multiple Airlines
Mon 6/112:33 pm
RDU
- TYS
2 stops9h 28m
Multiple Airlines
Deal found 4/28![Multiple Airlines logo]()
$199
One-way flights from Knoxville to DurhamSearch for one-way flight options from Knoxville to Durham. Find affordable one-way fares based on user searches. Data last updated May 1, 2026.
Search for one-way flight options from Knoxville to Durham. Find affordable one-way fares based on user searches. Data last updated May 1, 2026.
This Kiwi.com deal was found by Cheapflights users on 4/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 5/2912:55 pm
TYS
- RDU
2 stops19h 09m
Multiple Airlines
Deal found 4/26![Multiple Airlines logo]()
$103
This Kiwi.com deal was found by Cheapflights users on 4/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 5/181:15 pm
TYS
- RDU
1 stop20h 06m
Multiple Airlines
Deal found 4/27![Multiple Airlines logo]()
$105
This Kiwi.com deal was found by Cheapflights users on 4/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 5/111:15 pm
TYS
- RDU
1 stop20h 06m
Multiple Airlines
Deal found 4/28![Multiple Airlines logo]()
$111
This Kiwi.com deal was found by Cheapflights users on 4/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 7/214:20 pm
TYS
- RDU
1 stop24h 24m
Multiple Airlines
Deal found 4/28![Multiple Airlines logo]()
$113
This Kiwi.com deal was found by Cheapflights users on 4/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 7/81:05 pm
TYS
- RDU
1 stop25h 10m
Multiple Airlines
Deal found 4/29![Multiple Airlines logo]()
$124
This Kiwi.com deal was found by Cheapflights users on 4/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 5/64:25 pm
TYS
- RDU
1 stop18h 27m
Multiple Airlines
Deal found 4/27![Multiple Airlines logo]()
$127
This Kiwi.com deal was found by Cheapflights users on 4/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 6/289:38 pm
TYS
- RDU
1 stop18h 55m
Multiple Airlines
Deal found 4/26![Multiple Airlines logo]()
$136
This Delta deal was found by Cheapflights users on 4/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 5/195:40 am
TYS
- RDU
1 stop6h 12m
Delta
Deal found 4/27![Delta logo]()
$140
Find flight deals from Knoxville to Durham
Keep the following information in mind while searching for Knoxville to Durham flight deals. Data was last updated May 1, 2026.
Most accurate provider | FlightHub 3 stars |
|---|---|
Most trusted provider | FlightHub 3 stars |
Round-trip from | $197 (Kiwi.com) |
One-way from | $103 (Kiwi.com) |
Popular in | February |
Cheapest in | June |
Average price | $293 |
Cheapflights Fare Finder
Customize your flight search to find flights from Knoxville to Durham that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated May 1, 2026.
Use the filters below to find and compare flights from Knoxville to Durham that are best for you.
Fly from
Fly to
Route
Depart
Return
Cheapest round-trip
KnoxvilleRaleigh
TYS - RDU
TYSRDU
Knoxville McGhee Tyson
Wed 5/27
2:20 pm-9:21 am
1 stop19h 01m
Raleigh-Durham
Wed 6/3
7:52 pm-10:29 pm
1 stop26h 37m
$197
KnoxvilleRaleigh
TYS - RDU
TYSRDU
Knoxville McGhee Tyson
Fri 5/29
10:03 pm-9:00 am
1 stop10h 57m
Raleigh-Durham
Mon 6/1
2:32 pm-11:37 pm
1 stop9h 05m
$212
KnoxvilleRaleigh
TYS - RDU
TYSRDU
Knoxville McGhee Tyson
Wed 5/27
1:01 pm-10:52 am
1 stop21h 51m
Raleigh-Durham
Sun 5/31
12:54 pm-4:40 pm
2 stops27h 46m
$235
KnoxvilleRaleigh
TYS - RDU
TYSRDU
Knoxville McGhee Tyson
Sun 6/7
7:15 am-2:22 pm
1 stop7h 07m
Raleigh-Durham
Wed 6/10
7:45 pm-8:30 pm
1 stop24h 45m
$283
KnoxvilleRaleigh
TYS - RDU
TYSRDU
Knoxville McGhee Tyson
Mon 5/11
1:15 pm-9:21 am
1 stop20h 06m
Raleigh-Durham
Thu 5/14
12:53 pm-12:25 pm
2 stops23h 32m
$304
Quickest round-trip
KnoxvilleRaleigh
TYS - RDU
TYSRDU
Knoxville McGhee Tyson
Mon 6/15
6:40 am-12:40 pm
1 stop6h 00m
Raleigh-Durham
Tue 6/16
4:10 pm-8:20 pm
1 stop4h 10m
$308
KnoxvilleRaleigh
TYS - RDU
TYSRDU
Knoxville McGhee Tyson
Fri 5/22
6:35 am-6:30 pm
2 stops11h 55m
Raleigh-Durham
Mon 5/25
2:00 pm-8:20 pm
2 stops6h 20m
$362
KnoxvilleRaleigh
TYS - RDU
TYSRDU
Knoxville McGhee Tyson
Wed 5/27
7:05 am-4:30 pm
2 stops9h 25m
Raleigh-Durham
Wed 6/3
9:50 am-7:40 pm
2 stops9h 50m
$378
KnoxvilleRaleigh
TYS - RDU
TYSRDU
Knoxville McGhee Tyson
Mon 6/8
6:40 am-6:55 pm
2 stops12h 15m
Raleigh-Durham
Tue 6/9
11:15 am-8:20 pm
2 stops9h 05m
$393
KnoxvilleRaleigh
TYS - RDU
TYSRDU
Knoxville McGhee Tyson
Tue 5/12
7:05 am-12:45 pm
1 stop5h 40m
Raleigh-Durham
Wed 5/13
6:40 am-12:00 pm
1 stop5h 20m
$437
Showing 1-10 of 17 resultsSorted by cheapest first
Best time to book a flight from Knoxville to Durham
Have a flexible travel schedule? Discover the best time to fly to Durham from Knoxville with our price prediction graph.
TYS-RDU
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.
Cheapflights Insights
Everything you need to know about your flight from Knoxville to Durham
TYS-DU8
TYS-RDU
How much does it cost to fly round-trip from Knoxville to Durham?
Reviews of airlines servicing Durham
Get insights into the airlines that provide service to Durham. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Durham. Reviews last updated May 1, 2026.
Read reviews from past customers who have flown Delta,United Airlines, andAmerican Airlines from Knoxville to Durham. Users can see the overall rating for each airline as well as how each is rated in terms of entertainment options, comfort, food, crew/service, and boarding process.
Crew
8.5
Food
7.2
Boarding
8.1
Comfort
7.9
Overall
7.9
Entertainment
7.8
Reviews
1 / 20
6.0
GoodJim,Nov 2025
AVL - ATL
Crew
8.5
Food
7.2
Boarding
8.1
Comfort
7.9
Overall
7.9
Entertainment
7.8
Reviews
1 / 20
6.0
GoodJim,Nov 2025
AVL - ATL
Crew
8.5
Food
7.2
Boarding
8.1
Comfort
7.9
Overall
7.9
Entertainment
7.8
Reviews
1 / 20
6.0
GoodJim,Nov 2025
AVL - ATL
Crew
8.5
Food
7.2
Boarding
8.1
Comfort
7.9
Overall
7.9
Entertainment
7.8
Reviews
1 / 20
6.0
GoodJim,Nov 2025
AVL - ATL
Related info for your journey
Find useful and relevant information for your journey from Knoxville to Durham. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.
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Toggle through the tabs below to find thousands of options on Cheapflights for your next trip.
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Complete your trip
Complete your trip to Durham by adding a car rental and/or hotel reservation to your travel itinerary.
Search flights from Knoxville to Durham by cabin class
Find flights from Knoxville to Durham, based on your preferred cabin class, be it economy, premium economy, business, or first class.
Knoxville and Durham flights
Browse other Knoxville and Durham flight options. Last updated on May 1, 2026.
Other flights from Knoxville
Browse through other flights departing from Knoxville. Flights are based on user searches made on Cheapflights and were last updated on May 1, 2026.
Popular flight searches
Check out other popular destinations found by fellow travelers in 2026
Knoxville to Durham flights
Consider these flights traveling from Knoxville to Durham.
Top 3 airlines flying from Knoxville to Durham
Discover the top 3 airlines that operate flights from Knoxville to Durham. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated May 1, 2026.
| Airline | Cheapest | Average | Flexibility | On-time |
|---|---|---|---|---|
| Cheapest$218 | Average$337 | FlexibilityNo cancel fee | On-time71% | |
| Cheapest$218 | Average$421 | FlexibilityNo cancel fee | On-timeN/A | |
| Cheapest$233 | Average$371 | FlexibilityNo cancel fee | On-time69% |