In terms of precipitation, rainfall in Knoxville ranges from 2.7 - 4.8 inches per month. March is typically the wettest month, when rainfall can reach 4.8 in. October is typically the driest time to visit Knoxville when rainfall is around 2.7 in.

If weather is an important factor for your trip to Knoxville, use this chart to help with planning. For those seeking warmer temperatures, July is the ideal time of year to visit, when temperatures reach an average of 78.8 F. Travelers looking to avoid the cold should look outside of January, when temperatures are typically at their lowest (around 39.2 F).

What is the cheapest time of day to fly from DU8 to TYS?

Regardless of the time of day you decide to fly, the ticket price will remain around the same. Book flights from Durham to Knoxville as you normally would.

What airport do you fly into for flights to Knoxville from Durham?

If you book a flight to Knoxville from Durham, you will be flying to McGhee Tyson, which is the city’s only airport. Knoxville McGhee Tyson (TYS) is located 11.3 mi from the center of Knoxville. There are 0 flights from Durham to McGhee Tyson per day from 2 different airlines.

Can I find deals for flights from Durham to Knoxville that include hotel bookings?

Yes. In addition to deals on Durham to Knoxville flights, Cheapflights offers vacation packages that include both flights and hotel.

How can I find direct flights from Durham to Knoxville?

After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Durham to Knoxville.

Can I find deals for business class flights from Durham to Knoxville?

Yes. Cheapflights offers flight deals from Durham to Knoxville by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

Find Cheap Flights from Durham to Knoxville

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Find flight deals from Durham to Knoxville

Most accurate provider	FlightHub 3 stars
Most trusted provider	FlightHub 3 stars
Popular in	July
Cheapest in	April
Average price	$468

Provider with most accurate pricing for Raleigh-Durham-Knoxville McGhee Tyson flight deals.

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Provider most trusted by Cheapflights users for Raleigh-Durham-Knoxville McGhee Tyson flights.

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High demand for flights, 1% potential price rise

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Cheapest flight prices on average. 4% potential price decrease ($19 potential savings vs. average RT price).

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Average for round-trip flights in September 2026

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Reviews of airlines servicing Knoxville

Peruse reviews from past customers who have flown with Delta and American Airlines from Durham to Knoxville to help guide your decision. You can also see how each airline stacks up in terms of entertainment options, comfort, food, crew/service, and boarding process.

Delta

7.8

Good

8,591 reviews

Reviews

1 / 20

4.0

Okay

Jennifer,Sep 2026

ORD - LGA

The flight crew was 30 minutes late to an am flight and then that caused a delay

Delta

7.8

Good

8,591 reviews

Delta

7.8

Good

8,591 reviews

Reviews

1 / 20

4.0

Okay

Jennifer,Sep 2026

ORD - LGA

The flight crew was 30 minutes late to an am flight and then that caused a delay

American Airlines

7.0

Good

12,075 reviews

Delta

7.8

Good

8,591 reviews

Reviews

1 / 20

4.0

Okay

Jennifer,Sep 2026

ORD - LGA

The flight crew was 30 minutes late to an am flight and then that caused a delay

Related info for your journey

What airport do you fly into for flights to Knoxville from Durham?
If you book a flight to Knoxville from Durham, you will be flying to McGhee Tyson, which is the city’s only airport. Knoxville McGhee Tyson (TYS) is located 11.3 mi from the center of Knoxville. There are 0 flights from Durham to McGhee Tyson per day from 2 different airlines.
Can I find deals for flights from Durham to Knoxville that include hotel bookings?
Yes. In addition to deals on Durham to Knoxville flights, Cheapflights offers vacation packages that include both flights and hotel.
How can I find direct flights from Durham to Knoxville?
After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Durham to Knoxville.
Can I find deals for business class flights from Durham to Knoxville?
Yes. Cheapflights offers flight deals from Durham to Knoxville by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

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Top 2 airlines flying from Durham to Knoxville

Airline	Cheapest	Average	Flexibility	On-time
Delta	Cheapest$232	Average$382	FlexibilityNo cancel fee	On-timeN/A
American Airlines	Cheapest$262	Average$396	FlexibilityNo cancel fee	On-time71%

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Find cheap flights from Durham to Knoxville with Cheapflights

1. Tell us where you want to go

2. Select your favorite providers

3. Compare prices and book

Find flight deals from Durham to Knoxville

Most accurate provider

Most trusted provider

Popular in

Cheapest in

Average price

Reviews of airlines servicing Knoxville

Peruse reviews from past customers who have flown with Delta and American Airlines from Durham to Knoxville to help guide your decision. You can also see how each airline stacks up in terms of entertainment options, comfort, food, crew/service, and boarding process.

Related info for your journey

What airport do you fly into for flights to Knoxville from Durham?

Can I find deals for flights from Durham to Knoxville that include hotel bookings?

How can I find direct flights from Durham to Knoxville?

Can I find deals for business class flights from Durham to Knoxville?

Traveling to a place near Knoxville?

Browse thousands of different options on Cheapflights for your next trip

Toggle through the tabs below to find thousands of options on Cheapflights for your next trip.

Alternative routes for Durham to Knoxville

See prices for flight routes from nearby airports that may be better suited for you.

Complete your trip

Complete your trip to Knoxville by adding a car rental and/or hotel reservation to your travel itinerary.

Search flights from Durham to Knoxville by cabin class

Find flights from Durham to Knoxville, based on your preferred cabin class, be it economy, premium economy, business, or first class.

Other flights to Knoxville

Explore flights to Knoxville departing from other origins. Flights are based on user searches made on Cheapflights and were last updated on September 23, 2026.

Durham and Knoxville flights

Browse other Durham and Knoxville flight options. Last updated on September 23, 2026.

Popular flight searches

Check out other popular destinations found by fellow travelers in 2026

Durham to Knoxville flights

Consider these flights traveling from Durham to Knoxville.

Top 2 airlines flying from Durham to Knoxville

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Book with Flexibility

Travel Smart

Cheap flights from Durham, NC to Knoxville (TYS)

Find cheap flights from Durham to Knoxville with Cheapflights

1. Tell us where you want to go

2. Select your favorite providers

3. Compare prices and book

Find flight deals from Durham to Knoxville

Most accurate provider

Most trusted provider

Popular in

Cheapest in

Average price

Reviews of airlines servicing Knoxville

Peruse reviews from past customers who have flown with Delta and American Airlines from Durham to Knoxville to help guide your decision. You can also see how each airline stacks up in terms of entertainment options, comfort, food, crew/service, and boarding process.

Related info for your journey

What airport do you fly into for flights to Knoxville from Durham?

Can I find deals for flights from Durham to Knoxville that include hotel bookings?

How can I find direct flights from Durham to Knoxville?

Can I find deals for business class flights from Durham to Knoxville?

Traveling to a place near Knoxville?

Browse thousands of different options on Cheapflights for your next trip

Toggle through the tabs below to find thousands of options on Cheapflights for your next trip.

Alternative routes for Durham to Knoxville

See prices for flight routes from nearby airports that may be better suited for you.

Complete your trip

Complete your trip to Knoxville by adding a car rental and/or hotel reservation to your travel itinerary.

Search flights from Durham to Knoxville by cabin class

Find flights from Durham to Knoxville, based on your preferred cabin class, be it economy, premium economy, business, or first class.

Other flights to Knoxville

Explore flights to Knoxville departing from other origins. Flights are based on user searches made on Cheapflights and were last updated on September 23, 2026.

Durham and Knoxville flights

Browse other Durham and Knoxville flight options. Last updated on September 23, 2026.

Popular flight searches

Check out other popular destinations found by fellow travelers in 2026

Durham to Knoxville flights

Consider these flights traveling from Durham to Knoxville.

Top 2 airlines flying from Durham to Knoxville

100% Free

Book with Flexibility

Travel Smart