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Knoxville

$99+ Cheap flights from Durham, NC to Knoxville (TYS)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 6/2. Fares are subject to change and may not be available on all flights or dates of travel.
RDU — TYS
May 31 — Jun 71
Sun 5/31
Sun 6/7
1 adult, Economy
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Cheap flight deals from Durham to Knoxville

Cheapest flights from Durham to Knoxville
Explore the most affordable flight options available from Durham to Knoxville. Find the lowest fares from popular airlines and budget airlines, with prices last updated on May 1, 2026.

This Kiwi.com deal was found by Cheapflights users on 4/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 5/2810:15 pm
RDU
-
TYS
1 stop25h 22m
Multiple Airlines
Mon 6/17:24 pm
TYS
-
RDU
1 stop13h 57m
Multiple Airlines
Deal found 4/29$160
This Kiwi.com deal was found by Cheapflights users on 4/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 5/257:52 pm
RDU
-
TYS
1 stop20h 18m
Multiple Airlines
Mon 6/17:24 pm
TYS
-
RDU
1 stop13h 57m
Multiple Airlines
Deal found 4/26$165
This Kiwi.com deal was found by Cheapflights users on 4/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 5/277:52 pm
RDU
-
TYS
1 stop27h 14m
Multiple Airlines
Mon 6/110:03 pm
TYS
-
RDU
1 stop11h 18m
Multiple Airlines
Deal found 4/28$178
This Kiwi.com deal was found by Cheapflights users on 4/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 6/29:46 am
RDU
-
TYS
1 stop6h 29m
Multiple Airlines
Mon 6/87:27 pm
TYS
-
RDU
1 stop13h 52m
Multiple Airlines
Deal found 4/30$181
This Kiwi.com deal was found by Cheapflights users on 4/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 5/2810:15 pm
RDU
-
TYS
1 stop25h 22m
Multiple Airlines
Thu 6/43:42 pm
TYS
-
RDU
1 stop17h 18m
Multiple Airlines
Deal found 4/29$183
This Kiwi.com deal was found by Cheapflights users on 4/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 5/182:32 pm
RDU
-
TYS
1 stop19h 08m
Multiple Airlines
Wed 5/202:20 pm
TYS
-
RDU
1 stop19h 01m
Multiple Airlines
Deal found 4/27$192
This Kiwi.com deal was found by Cheapflights users on 4/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 5/269:46 am
RDU
-
TYS
1 stop6h 29m
Multiple Airlines
Mon 6/17:24 pm
TYS
-
RDU
1 stop13h 57m
Multiple Airlines
Deal found 4/29$195
This Kiwi.com deal was found by Cheapflights users on 4/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 6/1912:10 pm
RDU
-
TYS
2 stops9h 40m
Multiple Airlines
Mon 6/227:26 pm
TYS
-
RDU
1 stop13h 53m
Multiple Airlines
Deal found 4/27$196

Find flight deals from Durham to Knoxville

Keep the following information in mind while searching for Durham to Knoxville flight deals. Data was last updated May 1, 2026.

Most accurate provider

FlightHub
3 stars

Most trusted provider

FlightHub
3 stars

Round-trip from

$160
(Kiwi.com)

One-way from

$99
(Kiwi.com)

Popular in

February

Cheapest in

August

Average price

$518
Provider with most accurate pricing for Raleigh-Durham-Knoxville McGhee Tyson flight deals.
Search Deals
Provider most trusted by Cheapflights users for Raleigh-Durham-Knoxville McGhee Tyson flights.
Search Deals
From Durham to Knoxville McGhee Tyson
Search Deals
One-way flight from Durham to Knoxville McGhee Tyson
Search Deals
Highest demand for flights based on searches. 16% potential increase in price ($85 potential increase over avg. RT price).
Search Deals
Cheapest flight prices on average. 4% potential price decrease ($19 potential savings vs. average RT price).
Search Deals
Average for round-trip flights in May 2026
Search Deals

Cheapflights Fare Finder

 
Customize your flight search to find flights from Durham to Knoxville that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated May 1, 2026.
Use the filters below to find and compare flights from Durham to Knoxville that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Cheapest round-trip

RaleighKnoxville

RDU - TYS

RDUTYS

Raleigh-Durham

Sat 5/30

9:30 pm-12:26 pm

1 stop14h 56m

Knoxville McGhee Tyson

Sat 6/6

8:47 pm-10:52 am

1 stop14h 05m

$216

RaleighKnoxville

RDU - TYS

RDUTYS

Raleigh-Durham

Wed 5/27

7:45 pm-8:29 pm

1 stop24h 44m

Knoxville McGhee Tyson

Mon 6/1

7:24 pm-9:21 am

1 stop13h 57m

$226

RaleighKnoxville

RDU - TYS

RDUTYS

Raleigh-Durham

Mon 6/1

4:50 pm-9:15 pm

1 stop4h 25m

Knoxville McGhee Tyson

Tue 6/2

5:50 pm-9:35 pm

1 stop3h 45m

$289

RaleighKnoxville

RDU - TYS

RDUTYS

Raleigh-Durham

Mon 5/18

2:00 pm-8:20 pm

2 stops6h 20m

Knoxville McGhee Tyson

Sat 5/23

6:40 am-12:15 pm

1 stop5h 35m

$304
Quickest round-trip

RaleighKnoxville

RDU - TYS

RDUTYS

Raleigh-Durham

Wed 5/27

5:20 am-9:34 am

1 stop4h 14m

Knoxville McGhee Tyson

Sun 5/31

5:40 am-8:51 am

1 stop3h 11m

$308

RaleighKnoxville

RDU - TYS

RDUTYS

Raleigh-Durham

Sat 5/30

6:00 am-6:30 pm

2 stops12h 30m

Knoxville McGhee Tyson

Sat 6/6

6:55 pm-9:30 am

2 stops14h 35m

$329

RaleighKnoxville

RDU - TYS

RDUTYS

Raleigh-Durham

Fri 5/15

11:47 am-11:06 am

1 stop23h 19m

Knoxville McGhee Tyson

Sun 5/17

12:55 pm-10:43 pm

1 stop9h 48m

$332

RaleighKnoxville

RDU - TYS

RDUTYS

Raleigh-Durham

Sat 6/27

6:15 am-7:35 pm

2 stops13h 20m

Knoxville McGhee Tyson

Sun 6/28

7:00 pm-11:20 pm

1 stop4h 20m

$348

RaleighKnoxville

RDU - TYS

RDUTYS

Raleigh-Durham

Tue 6/2

9:50 am-7:40 pm

2 stops9h 50m

Knoxville McGhee Tyson

Mon 6/8

6:40 am-6:55 pm

2 stops12h 15m

$352

RaleighKnoxville

RDU - TYS

RDUTYS

Raleigh-Durham

Thu 5/21

5:20 am-9:34 am

1 stop4h 14m

Knoxville McGhee Tyson

Sun 5/24

5:40 am-8:51 am

1 stop3h 11m

$379

Flights are sorted by cheapest round-trip flights first.

Deals found on 4/28

Showing 1-10 of 20 resultsSorted by cheapest first
1
2

Best time to book a flight from Durham to Knoxville

Have a flexible travel schedule? Discover the best time to fly to Knoxville from Durham with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Durham to Knoxville

How much does it cost to fly round-trip from Durham to Knoxville?

Reviews of airlines servicing Knoxville

Get insights into the airlines that provide service to Knoxville. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Knoxville. Reviews last updated May 1, 2026.
Peruse reviews from past customers who have flown with Delta and American Airlines from Durham to Knoxville to help guide your decision. You can also see how each airline stacks up in terms of entertainment options, comfort, food, crew/service, and boarding process.
Delta
7.9
Good
8,464 reviews

Entertainment

7.8

Food

7.2

Overall

7.9

Boarding

8.1

Comfort

7.9

Crew

8.5

Reviews

1 / 20
6.0
Good

Jim,Nov 2025

AVL - ATL

The exit row seats without a seat in front are great for leg room but don’t have a fold out entertainment console so you’re forced to use the screen several feet in front of you (there is, at least, a remote). Best to bring a tablet loaded with entertainment or a book.
Delta
7.9
Good
8,464 reviews
Delta
7.9
Good
8,464 reviews

Entertainment

7.8

Food

7.2

Overall

7.9

Boarding

8.1

Comfort

7.9

Crew

8.5

Reviews

1 / 20
6.0
Good

Jim,Nov 2025

AVL - ATL

The exit row seats without a seat in front are great for leg room but don’t have a fold out entertainment console so you’re forced to use the screen several feet in front of you (there is, at least, a remote). Best to bring a tablet loaded with entertainment or a book.
American Airlines
7.1
Good
11,684 reviews
Delta
7.9
Good
8,464 reviews

Entertainment

7.8

Food

7.2

Overall

7.9

Boarding

8.1

Comfort

7.9

Crew

8.5

Reviews

1 / 20
6.0
Good

Jim,Nov 2025

AVL - ATL

The exit row seats without a seat in front are great for leg room but don’t have a fold out entertainment console so you’re forced to use the screen several feet in front of you (there is, at least, a remote). Best to bring a tablet loaded with entertainment or a book.

Related info for your journey

Find useful and relevant information for your journey from Durham to Knoxville. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airport do you fly into for flights to Knoxville from Durham?

    If you book a flight to Knoxville from Durham, you will be flying to McGhee Tyson, which is the city’s only airport. Knoxville McGhee Tyson (TYS) is located 11.3 mi from the center of Knoxville. There are 0 flights from Durham to McGhee Tyson per day from 2 different airlines.

  • How long is the flight from Durham to Knoxville?

    A quick flight from Durham to Knoxville can take about 4h 25m. Southwest provides one of the quickest options available for as low as $289. The distance from Durham to Knoxville is about 291 mi.

  • Can I find deals for flights from Durham to Knoxville that include hotel bookings?

    Yes. In addition to deals on Durham to Knoxville flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Durham to Knoxville?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Durham to Knoxville.

  • Can I find deals for business class flights from Durham to Knoxville?

    Yes. Cheapflights offers flight deals from Durham to Knoxville by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

See more FAQs

Traveling to a place near Knoxville?

Book flights to Knoxville if you plan to visit one of these locations
Cherokee
Crossville
Morristown
Bryson City
Murphy
Alcoa
Oak Ridge

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Top 2 airlines flying from Durham to Knoxville

Discover the top 2 airlines that operate flights from Durham to Knoxville. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated May 1, 2026.
AirlineCheapestAverageFlexibilityOn-time
DeltaCheapest$218Average$456FlexibilityNo cancel feeOn-timeN/A
American AirlinesCheapest$223Average$386FlexibilityNo cancel feeOn-time71%

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