$104+ Cheap flights from Durham, NC to Knoxville (TYS)
This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 8/30. Fares are subject to change and may not be available on all flights or dates of travel.
RDU — TYS
Sep 2 — Sep 91
Round-trip
1 adult, Economy
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Find cheap flights from Durham to Knoxville with Cheapflights
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Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”2. Select your favorite providers
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Review each provider’s pricing and select the best option for you! Book through your favorite provider’s website for a seamless experience.Cheap flight deals from Durham to Knoxville
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Best
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Cheapest flights from Durham to KnoxvilleExplore the most affordable flight options available from Durham to Knoxville. Find the lowest fares from popular airlines and budget airlines, with prices last updated on August 3, 2026.
Explore the most affordable flight options available from Durham to Knoxville. Find the lowest fares from popular airlines and budget airlines, with prices last updated on August 3, 2026.
This Kiwi.com deal was found by Cheapflights users on 7/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/29:35 pm
RDU
- TYS
1 stop12h 02m
Multiple Airlines
Mon 10/59:28 pm
TYS
- RDU
1 stop11h 41m
Multiple Airlines
Deal found 7/29![Multiple Airlines logo]()
$199
This Kiwi.com deal was found by Cheapflights users on 7/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 8/279:59 pm
RDU
- TYS
1 stop21h 06m
Multiple Airlines
Thu 9/312:52 pm
TYS
- RDU
1 stop9h 36m
Multiple Airlines
Deal found 7/30![Multiple Airlines logo]()
$201
This Kiwi.com deal was found by Cheapflights users on 7/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 11/210:05 am
RDU
- TYS
1 stop8h 47m
Multiple Airlines
Thu 11/56:33 pm
TYS
- RDU
1 stop4h 07m
Multiple Airlines
Deal found 7/30![Multiple Airlines logo]()
$219
This Kiwi.com deal was found by Cheapflights users on 8/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 8/219:13 am
RDU
- TYS
1 stop9h 52m
Multiple Airlines
Sun 8/2312:55 pm
TYS
- RDU
1 stop9h 33m
Multiple Airlines
Deal found 8/2![Multiple Airlines logo]()
$221
This Kiwi.com deal was found by Cheapflights users on 7/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 9/121:14 pm
RDU
- TYS
1 stop23h 15m
Multiple Airlines
Sat 9/196:55 pm
TYS
- RDU
1 stop19h 04m
Multiple Airlines
Deal found 7/29![Multiple Airlines logo]()
$225
Best flights from Durham to KnoxvilleDiscover carefully curated flight deals from Durham to Knoxville that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated August 3, 2026.
Discover carefully curated flight deals from Durham to Knoxville that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated August 3, 2026.
This Delta deal was found by Cheapflights users on 7/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 9/85:15 am
RDU
- TYS
1 stop5h 29m
Delta
Sat 9/1211:50 am
TYS
- RDU
1 stop5h 21m
Delta
Deal found 7/30![Delta logo]()
$233
This American Airlines deal was found by Cheapflights users on 8/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 8/222:04 pm
RDU
- TYS
1 stop3h 30m
American Airlines
Tue 8/256:05 pm
TYS
- RDU
1 stop4h 48m
American Airlines
Deal found 8/2![American Airlines logo]()
$233
This Southwest deal was found by Cheapflights users on 7/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/910:15 am
RDU
- TYS
2 stops8h 45m
Southwest
Wed 9/167:00 am
TYS
- RDU
2 stops10h 35m
Southwest
Deal found 7/29![Southwest logo]()
$320
This Delta deal was found by Cheapflights users on 7/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 9/75:10 am
RDU
- TYS
1 stop4h 26m
Delta
Thu 9/107:50 am
TYS
- RDU
1 stop4h 43m
Delta
Deal found 7/31![Delta logo]()
$269
This Delta deal was found by Cheapflights users on 7/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 9/142:59 pm
RDU
- TYS
1 stop5h 16m
Delta
Mon 9/216:13 pm
TYS
- RDU
1 stop5h 07m
Delta
Deal found 7/31![Delta logo]()
$285
This Southwest deal was found by Cheapflights users on 7/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 9/126:40 am
RDU
- TYS
2 stops11h 05m
Southwest
Sat 9/196:50 am
TYS
- RDU
2 stops11h 20m
Southwest
Deal found 7/29![Southwest logo]()
$326
This Delta deal was found by Cheapflights users on 7/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/16:31 pm
RDU
- TYS
1 stop3h 19m
Delta
Sun 10/45:40 am
TYS
- RDU
1 stop4h 24m
Delta
Deal found 7/31![Delta logo]()
$308
This Southwest deal was found by Cheapflights users on 8/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/164:35 pm
RDU
- TYS
2 stops6h 05m
Southwest
Sat 10/178:10 am
TYS
- RDU
1 stop5h 25m
Southwest
Deal found 8/1![Southwest logo]()
$349
This Delta deal was found by Cheapflights users on 8/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/38:53 am
RDU
- TYS
1 stop4h 05m
Delta
Sun 10/45:40 am
TYS
- RDU
1 stop3h 14m
Delta
Deal found 8/2![Delta logo]()
$364
This Southwest deal was found by Cheapflights users on 7/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 8/1210:15 am
RDU
- TYS
2 stops8h 40m
Southwest
Thu 8/137:10 am
TYS
- RDU
2 stops8h 35m
Southwest
Deal found 7/29![Southwest logo]()
$457
This Southwest deal was found by Cheapflights users on 8/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 8/217:00 am
RDU
- TYS
2 stops11h 35m
Southwest
Sun 8/237:35 am
TYS
- RDU
2 stops12h 50m
Southwest
Deal found 8/2![Southwest logo]()
$490
This Southwest deal was found by Cheapflights users on 8/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 8/2012:30 pm
RDU
- TYS
2 stops6h 05m
Southwest
Sun 8/237:35 am
TYS
- RDU
2 stops12h 50m
Southwest
Deal found 8/2![Southwest logo]()
$529
Last-minute flights from Durham to KnoxvilleDiscover last-minute flight deals from Durham to Knoxville. Data last updated August 3, 2026 and is based on user searches.
Discover last-minute flight deals from Durham to Knoxville. Data last updated August 3, 2026 and is based on user searches.
This Kiwi.com deal was found by Cheapflights users on 8/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 8/219:13 am
RDU
- TYS
1 stop9h 52m
Multiple Airlines
Sun 8/2312:55 pm
TYS
- RDU
2 stops19h 37m
Multiple Airlines
Deal found 8/2![Multiple Airlines logo]()
$221
This American Airlines deal was found by Cheapflights users on 8/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 8/222:04 pm
RDU
- TYS
1 stop3h 30m
American Airlines
Tue 8/256:05 pm
TYS
- RDU
1 stop4h 48m
American Airlines
Deal found 8/2![American Airlines logo]()
$233
This Southwest deal was found by Cheapflights users on 8/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 8/228:10 am
RDU
- TYS
1 stop6h 30m
Southwest
Tue 8/257:00 am
TYS
- RDU
2 stops7h 55m
Southwest
Deal found 8/2![Southwest logo]()
$238
This Kiwi.com deal was found by Cheapflights users on 7/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 8/279:59 pm
RDU
- TYS
1 stop21h 06m
Multiple Airlines
Thu 9/312:52 pm
TYS
- RDU
1 stop9h 36m
Multiple Airlines
Deal found 7/30![Multiple Airlines logo]()
$201
This Kiwi.com deal was found by Cheapflights users on 7/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 9/121:14 pm
RDU
- TYS
1 stop23h 15m
Multiple Airlines
Sat 9/196:55 pm
TYS
- RDU
1 stop19h 04m
Multiple Airlines
Deal found 7/31![Multiple Airlines logo]()
$225
One-way flights from Durham to KnoxvilleSearch for one-way flight options from Durham to Knoxville. Find affordable one-way fares based on user searches. Data last updated August 3, 2026.
Search for one-way flight options from Durham to Knoxville. Find affordable one-way fares based on user searches. Data last updated August 3, 2026.
This Kiwi.com deal was found by Cheapflights users on 8/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 8/309:59 pm
RDU
- TYS
1 stop21h 04m
Multiple Airlines
Deal found 8/1![Multiple Airlines logo]()
$104
This Kiwi.com deal was found by Cheapflights users on 7/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/301:14 pm
RDU
- TYS
1 stop24h 02m
Multiple Airlines
Deal found 7/30![Multiple Airlines logo]()
$105
This Kiwi.com deal was found by Cheapflights users on 7/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 10/276:09 pm
RDU
- TYS
1 stop19h 44m
Multiple Airlines
Deal found 7/30![Multiple Airlines logo]()
$106
This Kiwi.com deal was found by Cheapflights users on 7/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 8/102:31 pm
RDU
- TYS
1 stop8h 13m
Multiple Airlines
Deal found 7/29![Multiple Airlines logo]()
$116
This Delta deal was found by Cheapflights users on 7/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 8/296:15 am
RDU
- TYS
1 stop3h 18m
Delta
Deal found 7/30![Delta logo]()
$117
This Southwest deal was found by Cheapflights users on 7/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 9/77:40 am
RDU
- TYS
1 stop9h 30m
Southwest
Deal found 7/30![Southwest logo]()
$122
This Kiwi.com deal was found by Cheapflights users on 8/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 8/137:52 pm
RDU
- TYS
1 stop24h 26m
Multiple Airlines
Deal found 8/1![Multiple Airlines logo]()
$125
This Southwest deal was found by Cheapflights users on 7/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 8/296:40 am
RDU
- TYS
2 stops11h 00m
Southwest
Deal found 7/30![Southwest logo]()
$128
This Kiwi.com deal was found by Cheapflights users on 8/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 9/251:56 pm
RDU
- TYS
2 stops23h 08m
Multiple Airlines
Deal found 8/2![Multiple Airlines logo]()
$131
This Kiwi.com deal was found by Cheapflights users on 7/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 8/159:56 pm
RDU
- TYS
1 stop21h 43m
Multiple Airlines
Deal found 7/31![Multiple Airlines logo]()
$132
Find flight deals from Durham to Knoxville
Keep the following information in mind while searching for Durham to Knoxville flight deals. Data was last updated August 3, 2026.
Most accurate provider | FlightHub 3 stars |
|---|---|
Most trusted provider | FlightHub 3 stars |
Round-trip from | $199 (Kiwi.com) |
One-way from | $104 (Kiwi.com) |
Popular in | February |
Cheapest in | April |
Average price | $336 |
Cheapflights Fare Finder
Customize your flight search to find flights from Durham to Knoxville that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated August 3, 2026.
Use the filters below to find and compare flights from Durham to Knoxville that are best for you.
Fly from
Fly to
Route
Depart
Return
Cheapest round-trip
RaleighKnoxville
RDU - TYS
RDUTYS
Raleigh-Durham
Tue 9/8
5:15 am-10:44 am
1 stop5h 29m
Knoxville McGhee Tyson
Sat 9/12
11:50 am-5:11 pm
1 stop5h 21m
$233
RaleighKnoxville
RDU - TYS
RDUTYS
Raleigh-Durham
Sat 8/22
2:04 pm-5:34 pm
1 stop3h 30m
Knoxville McGhee Tyson
Tue 8/25
6:05 pm-10:53 pm
1 stop4h 48m
$233
RaleighKnoxville
RDU - TYS
RDUTYS
Raleigh-Durham
Mon 9/7
5:10 am-9:36 am
1 stop4h 26m
Knoxville McGhee Tyson
Thu 9/10
7:50 am-12:33 pm
1 stop4h 43m
$269
RaleighKnoxville
RDU - TYS
RDUTYS
Raleigh-Durham
Mon 9/14
2:59 pm-8:15 pm
1 stop5h 16m
Knoxville McGhee Tyson
Mon 9/21
6:13 pm-11:20 pm
1 stop5h 07m
$285
RaleighKnoxville
RDU - TYS
RDUTYS
Raleigh-Durham
Thu 10/1
6:31 pm-9:50 pm
1 stop3h 19m
Knoxville McGhee Tyson
Sun 10/4
5:40 am-10:04 am
1 stop4h 24m
$308
RaleighKnoxville
RDU - TYS
RDUTYS
Raleigh-Durham
Wed 9/9
10:15 am-7:00 pm
2 stops8h 45m
Knoxville McGhee Tyson
Wed 9/16
7:00 am-5:35 pm
2 stops10h 35m
$320
RaleighKnoxville
RDU - TYS
RDUTYS
Raleigh-Durham
Sat 9/12
6:40 am-5:45 pm
2 stops11h 05m
Knoxville McGhee Tyson
Sat 9/19
6:50 am-6:10 pm
2 stops11h 20m
$326
RaleighKnoxville
RDU - TYS
RDUTYS
Raleigh-Durham
Fri 10/16
4:35 pm-10:40 pm
2 stops6h 05m
Knoxville McGhee Tyson
Sat 10/17
8:10 am-1:35 pm
1 stop5h 25m
$349
Quickest round-trip
RaleighKnoxville
RDU - TYS
RDUTYS
Raleigh-Durham
Sat 10/3
8:53 am-12:58 pm
1 stop4h 05m
Knoxville McGhee Tyson
Sun 10/4
5:40 am-8:54 am
1 stop3h 14m
$364
RaleighKnoxville
RDU - TYS
RDUTYS
Raleigh-Durham
Wed 8/12
10:15 am-6:55 pm
2 stops8h 40m
Knoxville McGhee Tyson
Thu 8/13
7:10 am-3:45 pm
2 stops8h 35m
$457
Showing 1-10 of 21 resultsSorted by cheapest first
Best time to book a flight from Durham to Knoxville
Have a flexible travel schedule? Discover the best time to fly to Knoxville from Durham with our price prediction graph.
RDU-TYS
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.
Cheapflights Insights
Everything you need to know about your flight from Durham to Knoxville
DU8-TYS
RDU-TYS
No data available for this route at this time. Please check back soon.
Reviews of airlines servicing Knoxville
Get insights into the airlines that provide service to Knoxville. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Knoxville. Reviews last updated August 3, 2026.
Peruse reviews from past customers who have flown with Delta and American Airlines from Durham to Knoxville to help guide your decision. You can also see how each airline stacks up in terms of entertainment options, comfort, food, crew/service, and boarding process.
Overall
7.8
Food
7.2
Crew
8.5
Entertainment
7.8
Boarding
8.1
Comfort
7.8
Reviews
1 / 20
6.0
GoodJim,Nov 2025
AVL - ATL
Overall
7.8
Food
7.2
Crew
8.5
Entertainment
7.8
Boarding
8.1
Comfort
7.8
Reviews
1 / 20
6.0
GoodJim,Nov 2025
AVL - ATL
Overall
7.8
Food
7.2
Crew
8.5
Entertainment
7.8
Boarding
8.1
Comfort
7.8
Reviews
1 / 20
6.0
GoodJim,Nov 2025
AVL - ATL
Related info for your journey
Find useful and relevant information for your journey from Durham to Knoxville. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.
Traveling to a place near Knoxville?
Book flights to Knoxville if you plan to visit one of these locationsCherokee
Crossville
Morristown
Bryson City
Murphy
Alcoa
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Other flights to Knoxville
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Top 2 airlines flying from Durham to Knoxville
Discover the top 2 airlines that operate flights from Durham to Knoxville. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated August 3, 2026.
| Airline | Cheapest | Average | Flexibility | On-time |
|---|---|---|---|---|
| Cheapest$232 | Average$391 | FlexibilityNo cancel fee | On-timeN/A | |
| Cheapest$262 | Average$396 | FlexibilityNo cancel fee | On-time71% |