HomeSearch by dateVacation packagesHotelsFlight dealsCar rentalTravel tips & news
Des Moines

$121+ Cheap flights from San Antonio to Des Moines (SAT - DSM)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 11/26. Fares are subject to change and may not be available on all flights or dates of travel.
SAT — DSM
Dec 13 — Dec 201
Sat 12/13
Sat 12/20
1 adult, Economy
We work with more than 300 partners to bring you better travel deals

Find cheap flights from San Antonio to Des Moines with Cheapflights

1. Tell us where you want to go

Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”

2. Select your favorite providers

We find the providers serving your travel needs. Choose up to four travel providers to compare side-by-side for flights, hotels, or car rentals.

3. Compare prices and book

Review each provider’s pricing and select the best option for you! Book through your favorite provider’s website for a seamless experience.

Cheap flight deals from San Antonio to Des Moines

Discover tips and strategies to find the most affordable flight options for your journey from San Antonio (SAT) to Des Moines (DSM). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated November 13, 2025.

Most accurate provider

Mytrip
3 stars

Most trusted provider

Mytrip
3 stars

Round-trip from

$378
(Delta)

One-way from

$121
(Priceline)

Popular in

December

Cheapest in

June

Average price

$687
Provider with most accurate pricing for San Antonio-Des Moines flight deals.
Search Deals
Provider most trusted by Cheapflights users for San Antonio-Des Moines flights.
Search Deals
From San Antonio to Des Moines
Search Deals
One-way flight from San Antonio to Des Moines
Search Deals
Highest demand for flights based on searches. 23% potential increase in price ($133 potential increase over avg. RT price).
Search Deals
Cheapest flight prices on average. 5% potential price decrease ($23 potential savings vs. average RT price).
Search Deals
Average for round-trip flights in November 2025
Search Deals

Find flight deals from San Antonio to Des Moines

Cheapest flights from San Antonio to Des Moines
Explore the most affordable flight options available from San Antonio to Des Moines. Find the lowest fares from popular airlines and budget airlines, with prices last updated on November 13, 2025.

This Kiwi.com deal was found by Cheapflights users on 11/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 11/227:37 pmSAT - DSM
1 stop12h 52mMultiple Airlines
Sun 11/238:19 pmDSM - SAT
1 stop13h 51mMultiple Airlines
Deal found 11/11$309
This Kiwi.com deal was found by Cheapflights users on 11/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 11/172:04 pmSAT - DSM
1 stop8h 36mMultiple Airlines
Sun 11/238:19 pmDSM - SAT
1 stop13h 51mMultiple Airlines
Deal found 11/11$385
This American Airlines deal was found by Cheapflights users on 11/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 12/56:17 amSAT - DSM
1 stop5h 25mAmerican Airlines
Sun 12/73:38 pmDSM - SAT
1 stop5h 09mAmerican Airlines
Deal found 11/11$407
This Kiwi.com deal was found by Cheapflights users on 11/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 12/2012:18 pmSAT - DSM
1 stop7h 26mFrontier
Mon 12/228:29 pmDSM - SAT
1 stop27h 48mFrontier
Deal found 11/13$412
This American Airlines deal was found by Cheapflights users on 11/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 12/236:44 amSAT - DSM
1 stop4h 03mAmerican Airlines
Sat 1/35:39 pmDSM - SAT
1 stop5h 20mAmerican Airlines
Deal found 11/12$413
This Kiwi.com deal was found by Cheapflights users on 11/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 12/205:10 amSAT - DSM
2 stops14h 34mMultiple Airlines
Mon 12/228:29 pmDSM - SAT
1 stop27h 48mMultiple Airlines
Deal found 11/13$427
This Southwest deal was found by Cheapflights users on 11/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 12/53:05 pmSAT - DSM
1 stop4h 50mSouthwest
Sun 12/75:45 amDSM - SAT
2 stops5h 45mSouthwest
Deal found 11/11$469

Cheapflights Fare Finder

 
Customize your flight search to find flights from San Antonio to Des Moines that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated November 13, 2025.
Use the filters below to find and compare flights from San Antonio to Des Moines that are best for you.

Fly from

San Antonio

Fly to

Des Moines

Route

Depart

Return

Price

San AntonioDes Moines

SAT - DSM

SATDSM

San Antonio

Sat 11/22

7:37 pm-8:29 am

1 stop12h 52m

Des Moines

Sun 11/23

8:19 pm-10:10 am

1 stop13h 51m

$309

San AntonioDes Moines

SAT - DSM

SATDSM

San Antonio

Mon 11/17

2:04 pm-10:40 pm

1 stop8h 36m

Des Moines

Sun 11/23

8:19 pm-10:10 am

1 stop13h 51m

$385

San AntonioDes Moines

SAT - DSM

SATDSM

San Antonio

Fri 12/5

6:17 am-11:42 am

1 stop5h 25m

Des Moines

Sun 12/7

3:38 pm-8:47 pm

1 stop5h 09m

$407

San AntonioDes Moines

SAT - DSM

SATDSM

San Antonio

Sat 12/20

12:18 pm-7:44 pm

1 stop7h 26m

Des Moines

Mon 12/22

8:29 pm-12:17 am

1 stop27h 48m

$412

San AntonioDes Moines

SAT - DSM

SATDSM

San Antonio

Sat 12/20

5:10 am-7:44 pm

2 stops14h 34m

Des Moines

Mon 12/22

8:29 pm-12:17 am

1 stop27h 48m

$427

San AntonioDes Moines

SAT - DSM

SATDSM

San Antonio

Tue 12/23

8:21 am-2:58 pm

1 stop6h 37m

Des Moines

Sat 1/3

5:39 pm-11:51 pm

1 stop6h 12m

$439

San AntonioDes Moines

SAT - DSM

SATDSM

San Antonio

Fri 12/5

3:05 pm-7:55 pm

1 stop4h 50m

Des Moines

Sun 12/7

5:45 am-11:30 am

2 stops5h 45m

$469

San AntonioDes Moines

SAT - DSM

SATDSM

San Antonio

Fri 12/5

5:20 am-4:12 pm

2 stops10h 52m

Des Moines

Sun 12/7

3:17 pm-11:00 pm

1 stop7h 43m

$483

San AntonioDes Moines

SAT - DSM

SATDSM

San Antonio

Wed 11/26

5:07 pm-9:01 am

2 stops15h 54m

$136

San AntonioDes Moines

SAT - DSM

SATDSM

San Antonio

Sun 1/18

5:30 am-11:24 am

1 stop5h 54m

$157

Flights are sorted by cheapest round-trip flights first.

Deals found on 11/11

Showing 1-10 of 15 results
1
2

Compare providers for flights from San Antonio to Des Moines

Provider information is updated monthly. Please note that these providers often have deals for this flight, but the availability may vary on a day-by-day basis on Cheapflights.
Use the table below to compare price accuracy, trust ratings, and cancellation policies for each provider offering flight deals from San Antonio to Des Moines in November.
ProviderPrice AccuracyTrust Score*
ExpediaPrice Accuracy2 starsTrust Score*3 stars
FlightHubPrice Accuracy3 starsTrust Score*1 star
eDreamsPrice Accuracy3 starsTrust Score*3 stars
MytripPrice Accuracy3 starsTrust Score*3 stars
PricelinePrice Accuracy1 starTrust Score*3 stars

*The Trust Score is based on feedback from users after their booking experience. It measures overall satisfaction, helping us identify issues like hidden fees, problems during the ticketing process, and the quality of customer service. This score is our best indicator of the provider's quality and reliability.

  • Most accurate provider: When it comes to deals on San Antonio-Des Moines flights, users find the pricing of Mytrip to be most consistent on Cheapflights vs. Mytrip Users can find the same prices on San Antonio-Des Moines flight deals on Cheapflights vs. Mytrip >95% of the time. Price accuracy is based on data collected from San Antonio-Des Moines flight searches over the past month and is updated monthly.
  • Most trusted provider: When it comes to deals on San Antonio-Des Moines flights, Cheapflights users trust Mytrip the most. Mytrip has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for San Antonio-Des Moines flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.

Best time to book a flight from San Antonio to Des Moines

Have a flexible travel schedule? Discover the best time to fly to Des Moines from San Antonio with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from San Antonio to Des Moines

What is the cheapest month to book a flight from San Antonio to Des Moines?

Currently, September is the cheapest month in which you can book a flight from San Antonio to Des Moines (average of $68). Flying from San Antonio to Des Moines in December is currently the most expensive (average of $144). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from SAT to DSM?

Find hourly flight availability from San Antonio to Des Moines. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated November 13, 2025.

One of the essential ways to save on airfare from San Antonio to Des Moines is to remain as flexible as possible. Flights that are in the afternoon tend to be the most expensive. A flight in the evening could potentially save you up to 39% on airfare.

Reviews of airlines servicing Des Moines

Get insights into the airlines that provide service to Des Moines. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Des Moines. Reviews last updated November 13, 2025.
See what other customers who have flown with Delta, United Airlines, and American Airlines from San Antonio to Des Moines have to say. You can also see how each airline compares in terms of entertainment options, comfort, food, crew/service, and boarding process.
Delta
7.9
Good
8,007 reviews

Comfort

7.9

Entertainment

7.9

Boarding

8.1

Overall

7.9

Food

7.3

Crew

8.5

Reviews

1 / 20
6.0
Good

Jim,Nov 2025

AVL - ATL

The exit row seats without a seat in front are great for leg room but don’t have a fold out entertainment console so you’re forced to use the screen several feet in front of you (there is, at least, a remote). Best to bring a tablet loaded with entertainment or a book.
Delta
7.9
Good
8,007 reviews
Delta
7.9
Good
8,007 reviews

Comfort

7.9

Entertainment

7.9

Boarding

8.1

Overall

7.9

Food

7.3

Crew

8.5

Reviews

1 / 20
6.0
Good

Jim,Nov 2025

AVL - ATL

The exit row seats without a seat in front are great for leg room but don’t have a fold out entertainment console so you’re forced to use the screen several feet in front of you (there is, at least, a remote). Best to bring a tablet loaded with entertainment or a book.
United Airlines
7.4
Good
9,017 reviews
Delta
7.9
Good
8,007 reviews

Comfort

7.9

Entertainment

7.9

Boarding

8.1

Overall

7.9

Food

7.3

Crew

8.5

Reviews

1 / 20
6.0
Good

Jim,Nov 2025

AVL - ATL

The exit row seats without a seat in front are great for leg room but don’t have a fold out entertainment console so you’re forced to use the screen several feet in front of you (there is, at least, a remote). Best to bring a tablet loaded with entertainment or a book.
American Airlines
7.2
Good
11,051 reviews
Delta
7.9
Good
8,007 reviews

Comfort

7.9

Entertainment

7.9

Boarding

8.1

Overall

7.9

Food

7.3

Crew

8.5

Reviews

1 / 20
6.0
Good

Jim,Nov 2025

AVL - ATL

The exit row seats without a seat in front are great for leg room but don’t have a fold out entertainment console so you’re forced to use the screen several feet in front of you (there is, at least, a remote). Best to bring a tablet loaded with entertainment or a book.

Related info for your journey

Find useful and relevant information for your journey from San Antonio to Des Moines. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • How long is the flight from San Antonio to Des Moines?

    Departing from San Antonio to Des Moines will take you 5h 25m. San Antonio and Des Moines are separated by a distance of 872 mi.

  • What are the cheapest airlines flying from San Antonio to Des Moines round-trip?

    Currently priced at $212, Delta will fly you from San Antonio to Des Moines and back. In addition to Delta, many other airlines offer competitively priced options for your trip. Search Cheapflights for deals from American Airlines and United Airlines - these airlines can fly you to your destination from $278 and $384, respectively. Delta is priced at 52% lower than the current average price of a flight leaving 3 months from now.

  • Can I find deals for flights from San Antonio to Des Moines that include hotel bookings?

    Yes. In addition to deals on San Antonio to Des Moines flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from San Antonio to Des Moines?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from San Antonio to Des Moines.

  • Can I find deals for business class flights from San Antonio to Des Moines?

    Yes. Cheapflights offers flight deals from San Antonio to Des Moines by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from San Antonio to Des Moines?

    Currently, September is the cheapest month in which you can book a flight from San Antonio to Des Moines (average of $68). Flying from San Antonio to Des Moines in December is currently the most expensive (average of $144). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Traveling to a place near Des Moines?

Book flights to Des Moines if you plan to visit one of these locations
Johnston
Altoona
Boone
Ames
West Des Moines
Ankeny

Browse thousands of different options on Cheapflights for your next trip

Toggle through the tabs below to find thousands of options on Cheapflights for your next trip.

Alternative routes for San Antonio to Des Moines

See prices for flight routes from nearby airports that may be better suited for you.
Dallas/Fort Worth to Omaha flights
Dallas/Fort Worth to Des Moines flights
Hobby to Omaha flights
Dallas/Fort Worth to Cedar Rapids flights
Dallas/Fort Worth to Moline flights
George Bush Intcntl to Omaha flights
Love Field to Omaha flights
Hobby to Des Moines flights
George Bush Intcntl to Des Moines flights
San Antonio to Moline flights
Austin to Omaha flights
Hobby to Cedar Rapids flights
Love Field to Des Moines flights
Austin to Moline flights
San Antonio to Omaha flights
Hobby to Moline flights
George Bush Intcntl to Moline flights
George Bush Intcntl to Cedar Rapids flights
Austin to Cedar Rapids flights
Love Field to Moline flights
Dallas/Fort Worth to Sioux City flights
Lubbock to Omaha flights
San Antonio to Cedar Rapids flights
Austin to Des Moines flights
El Paso to Omaha flights
El Paso to Cedar Rapids flights
El Paso to Des Moines flights
Corpus Christi to Des Moines flights
Love Field to Cedar Rapids flights
Hobby to Sioux City flights
McAllen to Omaha flights
Laredo to Cedar Rapids flights
Austin to Sioux City flights
El Paso to Moline flights
Austin to Waterloo flights
Harlingen to Des Moines flights
Hobby to La Crosse flights
Lubbock to Moline flights
Corpus Christi to Moline flights
George Bush Intcntl to La Crosse flights
Brownsville to Cedar Rapids flights
Corpus Christi to Cedar Rapids flights
San Antonio to La Crosse flights
Laredo to Omaha flights
Midland to Cedar Rapids flights
Austin to Dubuque flights
Dallas/Fort Worth to La Crosse flights

Top 3 airlines flying from San Antonio to Des Moines

Discover the top 3 airlines that operate flights from San Antonio to Des Moines. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated November 13, 2025.
AirlineCheapestAverageFlexibilityOn-time
DeltaCheapest$212Average$366FlexibilityNo cancel feeOn-timeN/A
American AirlinesCheapest$278Average$426FlexibilityNo cancel feeOn-time71%
United AirlinesCheapest$384Average$497FlexibilityNo cancel feeOn-time69%

100% Free

Cheapflights is completely free to use, so you can start saving the moment you arrive.

Book with Flexibility

Our users can plan ahead with confidence and find flights with no change fees

Travel Smart

Millions of people come to us for their flight needs every year. We help make travel planning easy by providing useful insights and data-driven graphs that can inform your decisions.