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Des Moines

$304+ Cheap flights from Mobile to Des Moines (MOB - DSM)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 2/23. Fares are subject to change and may not be available on all flights or dates of travel.
MOB — DSM
Mar 13 — Mar 201
Fri 3/13
Fri 3/20
1 adult, Economy
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Cheap flight deals from Mobile to Des Moines

Cheapest flights from Mobile to Des Moines
Explore the most affordable flight options available from Mobile to Des Moines. Find the lowest fares from popular airlines and budget airlines, with prices last updated on February 11, 2026.

This United Airlines deal was found by Cheapflights users on 2/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 2/247:00 am
MOB
-
DSM
2 stops13h 07m
United Airlines
Sat 2/282:59 pm
DSM
-
MOB
1 stop7h 00m
United Airlines
Deal found 2/7$349
This United Airlines deal was found by Cheapflights users on 2/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 2/94:50 pm
MOB
-
DSM
1 stop5h 40m
United Airlines
Sun 2/152:59 pm
DSM
-
MOB
1 stop7h 00m
United Airlines
Deal found 2/8$444
This United Airlines deal was found by Cheapflights users on 2/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 3/314:55 pm
MOB
-
DSM
1 stop5h 48m
United Airlines
Fri 4/33:21 pm
DSM
-
MOB
2 stops20h 29m
United Airlines
Deal found 2/9$453
This American Airlines deal was found by Cheapflights users on 2/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 2/135:15 am
MOB
-
DSM
1 stop8h 02m
American Airlines
Mon 2/165:00 am
DSM
-
MOB
2 stops12h 14m
American Airlines
Deal found 2/9$482

Find flight deals from Mobile to Des Moines

Discover tips and strategies to find the most affordable flight options for your journey from Mobile (MOB) to Des Moines (DSM). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated February 11, 2026.

Most accurate provider

FlightHub
3 stars

Most trusted provider

FlightHub
3 stars

Round-trip from

$349
(United Airlines)

One-way from

$304
(United Airlines)
Provider with most accurate pricing for Mobile-Des Moines flight deals.
Search Deals
Provider most trusted by Cheapflights users for Mobile-Des Moines flights.
Search Deals
From Mobile to Des Moines
Search Deals
One-way flight from Mobile to Des Moines
Search Deals

Cheapflights Fare Finder

 
Customize your flight search to find flights from Mobile to Des Moines that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated February 11, 2026.
Use the filters below to find and compare flights from Mobile to Des Moines that are best for you.

Fly from

Mobile

Fly to

Des Moines

Route

Depart

Return

Price

MobileDes Moines

MOB - DSM

MOBDSM

Mobile

Tue 2/24

7:00 am-8:07 pm

2 stops13h 07m

Des Moines

Sat 2/28

2:59 pm-9:59 pm

1 stop7h 00m

$349

MobileDes Moines

MOB - DSM

MOBDSM

Mobile

Mon 2/23

4:55 pm-10:20 pm

1 stop5h 25m

$304

MobileDes Moines

MOB - DSM

MOBDSM

Mobile

Fri 3/20

6:15 am-10:48 am

1 stop4h 33m

$680

Flights are sorted by cheapest round-trip flights first.

Deals found on 2/7

  • Most accurate provider: When it comes to deals on Mobile-Des Moines flights, users find the pricing of FlightHub to be most consistent on Cheapflights vs. FlightHub Users can find the same prices on Mobile-Des Moines flight deals on Cheapflights vs. FlightHub >95% of the time. Price accuracy is based on data collected from Mobile-Des Moines flight searches over the past month and is updated monthly.
  • Most trusted provider: When it comes to deals on Mobile-Des Moines flights, Cheapflights users trust FlightHub the most. FlightHub has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for Mobile-Des Moines flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.

Best time to book a flight from Mobile to Des Moines

Have a flexible travel schedule? Discover the best time to fly to Des Moines from Mobile with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Reviews of airlines servicing Des Moines

Get insights into the airlines that provide service to Des Moines. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Des Moines. Reviews last updated February 11, 2026.
Get a feel of what it's like to fly with American Airlines from Mobile to Des Moines by reading reviews from past customers. Users have also rated airlines in terms of entertainment options, comfort, food, crew/service, and boarding process.
American Airlines
7.2
Good
11,262 reviews

Comfort

7.2

Overall

7.2

Entertainment

6.9

Crew

8.0

Food

6.4

Boarding

7.5

Reviews

1 / 20
2.0
Mediocre

Susie,Jan 2026

CLT - TPA

This flight was delayed 3 or 4 times. We had boarded the plane, sat on plane for a good 30 minutes, then we had to board the aircraft, walk to a different gate, wait and then board another aircraft. We arrived in Tampa 4 hours later than the original booking. I feel there should have been some sort of compensation especially for the advantage members.
American Airlines
7.2
Good
11,262 reviews
American Airlines
7.2
Good
11,262 reviews

Comfort

7.2

Overall

7.2

Entertainment

6.9

Crew

8.0

Food

6.4

Boarding

7.5

Reviews

1 / 20
2.0
Mediocre

Susie,Jan 2026

CLT - TPA

This flight was delayed 3 or 4 times. We had boarded the plane, sat on plane for a good 30 minutes, then we had to board the aircraft, walk to a different gate, wait and then board another aircraft. We arrived in Tampa 4 hours later than the original booking. I feel there should have been some sort of compensation especially for the advantage members.

Related info for your journey

Find useful and relevant information for your journey from Mobile to Des Moines. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • How long is the flight from Mobile to Des Moines?

    There are many flights that can get you from Mobile to Des Moines in 13h 07m. Fly via United Airlines to get the fastest option. Airlines will cover a distance of 807 mi.

  • What is the cheapest airline to fly from Mobile to Des Moines round-trip?

    American Airlines, at $228, was found to be the cheapest airline from Mobile to Des Moines..

  • Can I find deals for flights from Mobile to Des Moines that include hotel bookings?

    Yes. In addition to deals on Mobile to Des Moines flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Mobile to Des Moines?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Mobile to Des Moines.

  • Can I find deals for business class flights from Mobile to Des Moines?

    Yes. Cheapflights offers flight deals from Mobile to Des Moines by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

See more FAQs

Traveling to a place near Des Moines?

Book flights to Des Moines if you plan to visit one of these locations
Altoona
Johnston
Boone
Ames
Clive
West Des Moines
Ankeny

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Top airline flying from Mobile to Des Moines

Discover the top airline that operate flights from Mobile to Des Moines. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated February 11, 2026.
AirlineCheapestAverageFlexibilityOn-time
American AirlinesCheapest$228Average$283FlexibilityNo cancel feeOn-time71%

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