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Des Moines

$139+ Cheap flights from Louisville to Des Moines (SDF - DSM)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 3/26. Fares are subject to change and may not be available on all flights or dates of travel.
SDF — DSM
Mar 14 — Mar 211
Sat 3/14
Sat 3/21
1 adult, Economy
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Cheap flight deals from Louisville to Des Moines

Cheapest flights from Louisville to Des Moines
Explore the most affordable flight options available from Louisville to Des Moines. Find the lowest fares from popular airlines and budget airlines, with prices last updated on February 12, 2026.

This Delta deal was found by Cheapflights users on 2/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 3/116:15 am
SDF
-
DSM
1 stop4h 54m
Delta
Wed 3/186:15 am
DSM
-
SDF
1 stop6h 22m
Delta
Deal found 2/11$251
This Southwest deal was found by Cheapflights users on 2/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 3/117:05 pm
SDF
-
DSM
1 stop4h 00m
Southwest
Wed 3/183:40 pm
DSM
-
SDF
2 stops6h 50m
Southwest
Deal found 2/11$256
This Delta deal was found by Cheapflights users on 2/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 3/127:05 am
SDF
-
DSM
1 stop4h 43m
Delta
Wed 3/186:55 am
DSM
-
SDF
1 stop3h 56m
Delta
Deal found 2/11$264
This Southwest deal was found by Cheapflights users on 2/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 3/123:35 pm
SDF
-
DSM
1 stop7h 45m
Southwest
Wed 3/183:40 pm
DSM
-
SDF
2 stops6h 50m
Southwest
Deal found 2/11$269
This Southwest deal was found by Cheapflights users on 2/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 3/166:35 am
SDF
-
DSM
2 stops6h 35m
Southwest
Wed 3/183:40 pm
DSM
-
SDF
2 stops6h 50m
Southwest
Deal found 2/11$274
This United Airlines deal was found by Cheapflights users on 2/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 3/139:00 am
SDF
-
DSM
1 stop6h 24m
United Airlines
Wed 3/182:04 pm
DSM
-
SDF
1 stop5h 10m
United Airlines
Deal found 2/11$289
This American Airlines deal was found by Cheapflights users on 2/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 3/136:00 am
SDF
-
DSM
1 stop5h 34m
American Airlines
Wed 3/1810:04 am
DSM
-
SDF
2 stops8h 03m
American Airlines
Deal found 2/11$294
This United Airlines deal was found by Cheapflights users on 2/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 3/67:05 am
SDF
-
DSM
1 stop4h 25m
United Airlines
Sat 3/72:04 pm
DSM
-
SDF
1 stop7h 09m
United Airlines
Deal found 2/11$312
This American Airlines deal was found by Cheapflights users on 2/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 3/66:00 am
SDF
-
DSM
1 stop5h 34m
American Airlines
Sat 3/75:00 am
DSM
-
SDF
2 stops9h 03m
American Airlines
Deal found 2/11$317
This American Airlines deal was found by Cheapflights users on 2/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 5/156:00 am
SDF
-
DSM
1 stop5h 26m
American Airlines
Sat 5/163:20 pm
DSM
-
SDF
1 stop5h 21m
American Airlines
Deal found 2/10$319

Find flight deals from Louisville to Des Moines

Discover tips and strategies to find the most affordable flight options for your journey from Louisville (SDF) to Des Moines (DSM). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated February 12, 2026.

Most accurate provider

FlightHub
3 stars

Most trusted provider

FlightHub
3 stars

Round-trip from

$251
(Delta)

One-way from

$139
(United Airlines)
Provider with most accurate pricing for Louisville Intl-Des Moines flight deals.
Search Deals
Provider most trusted by Cheapflights users for Louisville Intl-Des Moines flights.
Search Deals
From Louisville Intl to Des Moines
Search Deals
One-way flight from Louisville Intl to Des Moines
Search Deals

Cheapflights Fare Finder

 
Customize your flight search to find flights from Louisville to Des Moines that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated February 12, 2026.
Use the filters below to find and compare flights from Louisville to Des Moines that are best for you.

Fly from

Louisville

Fly to

Des Moines

Route

Depart

Return

Price

LouisvilleDes Moines

SDF - DSM

SDFDSM

Louisville Intl

Wed 3/11

6:15 am-10:09 am

1 stop4h 54m

Des Moines

Wed 3/18

6:15 am-1:37 pm

1 stop6h 22m

$251

LouisvilleDes Moines

SDF - DSM

SDFDSM

Louisville Intl

Wed 3/11

7:05 pm-10:05 pm

1 stop4h 00m

Des Moines

Wed 3/18

3:40 pm-11:30 pm

2 stops6h 50m

$256

LouisvilleDes Moines

SDF - DSM

SDFDSM

Louisville Intl

Thu 3/12

7:05 am-10:48 am

1 stop4h 43m

Des Moines

Wed 3/18

6:55 am-11:51 am

1 stop3h 56m

$264

LouisvilleDes Moines

SDF - DSM

SDFDSM

Louisville Intl

Mon 3/16

6:35 am-12:10 pm

2 stops6h 35m

Des Moines

Wed 3/18

3:40 pm-8:30 pm

1 stop3h 50m

$269

LouisvilleDes Moines

SDF - DSM

SDFDSM

Louisville Intl

Fri 3/13

6:00 am-10:34 am

1 stop5h 34m

Des Moines

Wed 3/18

10:04 am-7:07 pm

2 stops8h 03m

$294

LouisvilleDes Moines

SDF - DSM

SDFDSM

Louisville Intl

Thu 3/12

6:35 am-12:10 pm

2 stops6h 35m

Des Moines

Wed 3/18

3:40 pm-11:30 pm

2 stops6h 50m

$304

LouisvilleDes Moines

SDF - DSM

SDFDSM

Louisville Intl

Fri 3/6

7:05 am-10:30 am

1 stop4h 25m

Des Moines

Sat 3/7

2:04 pm-10:13 pm

1 stop7h 09m

$312

LouisvilleDes Moines

SDF - DSM

SDFDSM

Louisville Intl

Fri 5/15

6:00 am-10:26 am

1 stop5h 26m

Des Moines

Sat 5/16

3:20 pm-9:41 pm

1 stop5h 21m

$319

LouisvilleDes Moines

SDF - DSM

SDFDSM

Louisville Intl

Fri 3/13

6:00 am-10:34 am

1 stop5h 34m

Des Moines

Mon 3/16

7:44 pm-11:32 am

1 stop14h 48m

$332

LouisvilleDes Moines

SDF - DSM

SDFDSM

Louisville Intl

Thu 3/26

9:00 am-1:23 pm

1 stop5h 23m

$139

Flights are sorted by cheapest round-trip flights first.

Deals found on 2/11

Showing 1-10 of 12 results
1
2

Compare providers for flights from Louisville to Des Moines

Provider information is updated monthly. Please note that these providers often have deals for this flight, but the availability may vary on a day-by-day basis on Cheapflights.
Use the table below to compare price accuracy, trust ratings, and cancellation policies for each provider offering flight deals from Louisville to Des Moines in February.
ProviderPrice AccuracyTrust Score*
FlightHubPrice Accuracy3 starsTrust Score*3 stars
ExpediaPrice Accuracy1 starTrust Score*3 stars
MytripPrice Accuracy3 starsTrust Score*3 stars

*The Trust Score is based on feedback from users after their booking experience. It measures overall satisfaction, helping us identify issues like hidden fees, problems during the ticketing process, and the quality of customer service. This score is our best indicator of the provider's quality and reliability.

  • Most accurate provider: When it comes to deals on Louisville-Des Moines flights, users find the pricing of FlightHub to be most consistent on Cheapflights vs. FlightHub Users can find the same prices on Louisville-Des Moines flight deals on Cheapflights vs. FlightHub >95% of the time. Price accuracy is based on data collected from Louisville-Des Moines flight searches over the past month and is updated monthly.
  • Most trusted provider: When it comes to deals on Louisville-Des Moines flights, Cheapflights users trust FlightHub the most. FlightHub has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for Louisville-Des Moines flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.

Best time to book a flight from Louisville to Des Moines

Have a flexible travel schedule? Discover the best time to fly to Des Moines from Louisville with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Louisville to Des Moines

What is the cheapest month to book a flight from Louisville to Des Moines?

Currently, March is the cheapest month in which you can book a flight from Louisville to Des Moines (average of $154). Flying from Louisville to Des Moines in November is currently the most expensive (average of $426). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

Reviews of airlines servicing Des Moines

Get insights into the airlines that provide service to Des Moines. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Des Moines. Reviews last updated February 12, 2026.
Read through reviews of airlines operating flights from Louisville to Des Moines, such as Delta, United Airlines, and American Airlines. Reviews also offer insight into each airline's entertainment options, comfort, food, crew/service, and boarding process.
Delta
7.9
Good
8,179 reviews

Food

7.2

Comfort

7.9

Boarding

8.1

Entertainment

7.8

Overall

7.9

Crew

8.5

Reviews

1 / 20
6.0
Good

Jim,Nov 2025

AVL - ATL

The exit row seats without a seat in front are great for leg room but don’t have a fold out entertainment console so you’re forced to use the screen several feet in front of you (there is, at least, a remote). Best to bring a tablet loaded with entertainment or a book.
Delta
7.9
Good
8,179 reviews
Delta
7.9
Good
8,179 reviews

Food

7.2

Comfort

7.9

Boarding

8.1

Entertainment

7.8

Overall

7.9

Crew

8.5

Reviews

1 / 20
6.0
Good

Jim,Nov 2025

AVL - ATL

The exit row seats without a seat in front are great for leg room but don’t have a fold out entertainment console so you’re forced to use the screen several feet in front of you (there is, at least, a remote). Best to bring a tablet loaded with entertainment or a book.
United Airlines
7.4
Good
9,276 reviews
Delta
7.9
Good
8,179 reviews

Food

7.2

Comfort

7.9

Boarding

8.1

Entertainment

7.8

Overall

7.9

Crew

8.5

Reviews

1 / 20
6.0
Good

Jim,Nov 2025

AVL - ATL

The exit row seats without a seat in front are great for leg room but don’t have a fold out entertainment console so you’re forced to use the screen several feet in front of you (there is, at least, a remote). Best to bring a tablet loaded with entertainment or a book.
American Airlines
7.2
Good
11,267 reviews
Delta
7.9
Good
8,179 reviews

Food

7.2

Comfort

7.9

Boarding

8.1

Entertainment

7.8

Overall

7.9

Crew

8.5

Reviews

1 / 20
6.0
Good

Jim,Nov 2025

AVL - ATL

The exit row seats without a seat in front are great for leg room but don’t have a fold out entertainment console so you’re forced to use the screen several feet in front of you (there is, at least, a remote). Best to bring a tablet loaded with entertainment or a book.

Related info for your journey

Find useful and relevant information for your journey from Louisville to Des Moines. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • How long is the flight from Louisville to Des Moines?

    For as low as $256, Delta can have you in Des Moines from Louisville in 4h. Airlines will cover a distance of 480 mi. Both multi-stop and nonstop flights can be found to your destination and back.

  • What are the cheapest airlines flying from Louisville to Des Moines round-trip?

    Flying on Delta is currently your cheapest option to Des Moines, with prices starting at $105. Additional round-trip tickets that might be worth considering are offered by American Airlines and United Airlines, with the lowest prices starting at $196 and $223, respectively.

  • Can I find deals for flights from Louisville to Des Moines that include hotel bookings?

    Yes. In addition to deals on Louisville to Des Moines flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Louisville to Des Moines?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Louisville to Des Moines.

  • Can I find deals for business class flights from Louisville to Des Moines?

    Yes. Cheapflights offers flight deals from Louisville to Des Moines by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Louisville to Des Moines?

    Currently, March is the cheapest month in which you can book a flight from Louisville to Des Moines (average of $154). Flying from Louisville to Des Moines in November is currently the most expensive (average of $426). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Traveling to a place near Des Moines?

Book flights to Des Moines if you plan to visit one of these locations
Altoona
Johnston
Boone
Ames
Clive
West Des Moines
Ankeny

Browse thousands of different options on Cheapflights for your next trip

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Top 3 airlines flying from Louisville to Des Moines

Discover the top 3 airlines that operate flights from Louisville to Des Moines. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated February 12, 2026.
AirlineCheapestAverageFlexibilityOn-time
DeltaCheapest$105Average$326FlexibilityNo cancel feeOn-timeN/A
American AirlinesCheapest$196Average$305FlexibilityNo cancel feeOn-time71%
United AirlinesCheapest$223Average$386FlexibilityNo cancel feeOn-time69%

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