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Des Moines

$126+ Cheap flights from Louisville to Des Moines (SDF - DSM)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 11/11. Fares are subject to change and may not be available on all flights or dates of travel.
SDF — DSM
Nov 16 — Nov 231
Sun 11/16
Sun 11/23
1 adult, Economy
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Find flight deals from Louisville to Des Moines

Cheapest flights from Louisville to Des Moines
Explore the most affordable flight options available from Louisville to Des Moines. Find the lowest fares from popular airlines and budget airlines, with prices last updated on October 17, 2025.

This American Airlines deal was found by Cheapflights users on 10/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 12/298:00 amSDF - DSM
1 stop6h 21mAmerican Airlines
Mon 1/53:28 pmDSM - SDF
1 stop5h 06mAmerican Airlines
Deal found 10/16$296
This Delta deal was found by Cheapflights users on 10/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 11/27:09 amSDF - DSM
1 stop7h 19mDelta
Fri 11/76:39 pmDSM - SDF
1 stop4h 22mDelta
Deal found 10/16$367
This American Airlines deal was found by Cheapflights users on 10/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 11/212:43 pmSDF - DSM
1 stop3h 49mAmerican Airlines
Fri 11/74:02 pmDSM - SDF
2 stops6h 57mAmerican Airlines
Deal found 10/16$372
This Delta deal was found by Cheapflights users on 10/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 11/15:58 pmSDF - DSM
1 stop5h 32mDelta
Wed 11/55:32 pmDSM - SDF
1 stop4h 22mDelta
Deal found 10/17$387
This American Airlines deal was found by Cheapflights users on 10/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 11/112:21 pmSDF - DSM
1 stop6h 21mAmerican Airlines
Wed 11/52:19 pmDSM - SDF
2 stops8h 40mAmerican Airlines
Deal found 10/17$392
This Southwest deal was found by Cheapflights users on 10/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 10/283:50 pmSDF - DSM
2 stops7h 00mSouthwest
Thu 10/305:35 amDSM - SDF
2 stops9h 25mSouthwest
Deal found 10/15$457
This American Airlines deal was found by Cheapflights users on 10/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 10/288:18 amSDF - DSM
2 stops8h 59mAmerican Airlines
Thu 10/307:30 amDSM - SDF
1 stop5h 17mAmerican Airlines
Deal found 10/15$462

Cheap flight deals from Louisville to Des Moines

Discover tips and strategies to find the most affordable flight options for your journey from Louisville (SDF) to Des Moines (DSM). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated October 17, 2025.

Most accurate provider

FlightHub
3 stars

Most trusted provider

FlightHub
3 stars

Round-trip from

$252
(Delta)

One-way from

$126
(Delta)
Provider with most accurate pricing for Louisville Intl-Des Moines flight deals.
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Provider most trusted by Cheapflights users for Louisville Intl-Des Moines flights.
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From Louisville Intl to Des Moines
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One-way flight from Louisville Intl to Des Moines
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Cheapflights Fare Finder

 
Customize your flight search to find flights from Louisville to Des Moines that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated October 17, 2025.
Use the filters below to find and compare flights from Louisville to Des Moines that are best for you.

Fly from

Louisville

Fly to

Des Moines

Route

Depart

Return

Price

LouisvilleDes Moines

SDF - DSM

SDFDSM

Louisville Intl

Thu 2/19

6:36 am-10:22 am

1 stop4h 46m

Des Moines

Mon 2/23

5:15 pm-11:56 pm

1 stop5h 41m

$252

LouisvilleDes Moines

SDF - DSM

SDFDSM

Louisville Intl

Mon 12/29

5:49 pm-11:46 pm

1 stop6h 57m

Des Moines

Mon 1/5

3:27 pm-11:31 pm

1 stop7h 04m

$296

LouisvilleDes Moines

SDF - DSM

SDFDSM

Louisville Intl

Thu 2/19

6:57 am-12:30 pm

1 stop6h 33m

Des Moines

Mon 2/23

4:27 pm-12:39 am

2 stops7h 12m

$304

LouisvilleDes Moines

SDF - DSM

SDFDSM

Louisville Intl

Sun 11/2

7:09 am-1:28 pm

1 stop7h 19m

Des Moines

Fri 11/7

6:39 pm-12:01 am

1 stop4h 22m

$367

LouisvilleDes Moines

SDF - DSM

SDFDSM

Louisville Intl

Sun 11/2

12:43 pm-3:32 pm

1 stop3h 49m

Des Moines

Fri 11/7

4:02 pm-11:59 pm

2 stops6h 57m

$372

LouisvilleDes Moines

SDF - DSM

SDFDSM

Louisville Intl

Tue 11/11

8:35 am-1:32 pm

1 stop5h 57m

$126

LouisvilleDes Moines

SDF - DSM

SDFDSM

Louisville Intl

Tue 11/11

11:19 am-6:10 pm

2 stops7h 51m

$131

LouisvilleDes Moines

SDF - DSM

SDFDSM

Louisville Intl

Sat 10/25

10:04 am-8:02 am

1 stop22h 58m

$136

LouisvilleDes Moines

SDF - DSM

SDFDSM

Louisville Intl

Fri 11/7

9:00 am-2:19 pm

1 stop6h 19m

$174

LouisvilleDes Moines

SDF - DSM

SDFDSM

Louisville Intl

Fri 11/7

1:55 pm-11:35 pm

2 stops10h 40m

$194

Flights are sorted by cheapest round-trip flights first.

Deals found on 10/16

Showing 1-10 of 17 results
1
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Compare providers for flights from Louisville to Des Moines

Provider information is updated monthly. Please note that these providers often have deals for this flight, but the availability may vary on a day-by-day basis on Cheapflights.
Use the table below to compare price accuracy, trust ratings, and cancellation policies for each provider offering flight deals from Louisville to Des Moines in October.
ProviderPrice AccuracyTrust Score*
FlightHubPrice Accuracy3 starsTrust Score*3 stars
ExpediaPrice Accuracy2 starsTrust Score*3 stars
eDreamsPrice Accuracy3 starsTrust Score*3 stars

*The Trust Score is based on feedback from users after their booking experience. It measures overall satisfaction, helping us identify issues like hidden fees, problems during the ticketing process, and the quality of customer service. This score is our best indicator of the provider's quality and reliability.

  • Most accurate provider: When it comes to deals on Louisville-Des Moines flights, users find the pricing of FlightHub to be most consistent on Cheapflights vs. FlightHub Users can find the same prices on Louisville-Des Moines flight deals on Cheapflights vs. FlightHub >95% of the time. Price accuracy is based on data collected from Louisville-Des Moines flight searches over the past month and is updated monthly.
  • Most trusted provider: When it comes to deals on Louisville-Des Moines flights, Cheapflights users trust FlightHub the most. FlightHub has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for Louisville-Des Moines flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.

Best time to book a flight from Louisville to Des Moines

Have a flexible travel schedule? Discover the best time to fly to Des Moines from Louisville with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Louisville to Des Moines

What is the cheapest month to book a flight from Louisville to Des Moines?

Currently, March is the cheapest month in which you can book a flight from Louisville to Des Moines (average of $157). Flying from Louisville to Des Moines in December is currently the most expensive (average of $388). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from SDF to DSM?

Find hourly flight availability from Louisville to Des Moines. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated October 17, 2025.

It’s optimal to fly from Louisville to Des Moines in the afternoon. By choosing this option you can save up to 16% on the cost of your flight, compared to a flight at noon.

Reviews of airlines servicing Des Moines

Get insights into the airlines that provide service to Des Moines. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Des Moines. Reviews last updated October 17, 2025.
Read through reviews of airlines operating flights from Louisville to Des Moines, such as Delta, United Airlines, and American Airlines. Reviews also offer insight into each airline's entertainment options, comfort, food, crew/service, and boarding process.
Delta
7.9
Good
7,977 reviews

Crew

8.5

Comfort

7.9

Food

7.3

Overall

7.9

Boarding

8.2

Entertainment

7.9

Reviews

1 / 20
8.0
Excellent

Matthew,Oct 2025

GSP - ATL

This is always a full flight since it is the connecting route to primary destinations through Atlanta. That said, the crew handles the full load well. Not much more to say, it is a short flight with no in-flight services due to the length.
Delta
7.9
Good
7,977 reviews
Delta
7.9
Good
7,977 reviews

Crew

8.5

Comfort

7.9

Food

7.3

Overall

7.9

Boarding

8.2

Entertainment

7.9

Reviews

1 / 20
8.0
Excellent

Matthew,Oct 2025

GSP - ATL

This is always a full flight since it is the connecting route to primary destinations through Atlanta. That said, the crew handles the full load well. Not much more to say, it is a short flight with no in-flight services due to the length.
United Airlines
7.4
Good
8,987 reviews
Delta
7.9
Good
7,977 reviews

Crew

8.5

Comfort

7.9

Food

7.3

Overall

7.9

Boarding

8.2

Entertainment

7.9

Reviews

1 / 20
8.0
Excellent

Matthew,Oct 2025

GSP - ATL

This is always a full flight since it is the connecting route to primary destinations through Atlanta. That said, the crew handles the full load well. Not much more to say, it is a short flight with no in-flight services due to the length.
American Airlines
7.2
Good
11,036 reviews
Delta
7.9
Good
7,977 reviews

Crew

8.5

Comfort

7.9

Food

7.3

Overall

7.9

Boarding

8.2

Entertainment

7.9

Reviews

1 / 20
8.0
Excellent

Matthew,Oct 2025

GSP - ATL

This is always a full flight since it is the connecting route to primary destinations through Atlanta. That said, the crew handles the full load well. Not much more to say, it is a short flight with no in-flight services due to the length.

Related info for your journey

Find useful and relevant information for your journey from Louisville to Des Moines. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • How long is the flight from Louisville to Des Moines?

    For as low as $252, Delta can have you in Des Moines from Louisville in 4h 46m. Airlines will cover a distance of 480 mi. Both multi-stop and nonstop flights can be found to your destination and back.

  • What are the cheapest airlines flying from Louisville to Des Moines round-trip?

    Flying on Delta is currently your cheapest option to Des Moines, with prices starting at $105. Additional round-trip tickets that might be worth considering are offered by American Airlines and United Airlines, with the lowest prices starting at $158 and $246, respectively.

  • What are the cheapest airlines to fly from Louisville to Des Moines one-way?

    The cheapest airline one-way is Delta, with whom users have recently found tickets for as low as $126. However, be on the lookout for offers from American Airlines and Allegiant Air, as they are both options that can get you from Louisville to Des Moines for a low price.

  • Can I find deals for flights from Louisville to Des Moines that include hotel bookings?

    Yes. In addition to deals on Louisville to Des Moines flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Louisville to Des Moines?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Louisville to Des Moines.

  • Can I find deals for business class flights from Louisville to Des Moines?

    Yes. Cheapflights offers flight deals from Louisville to Des Moines by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Louisville to Des Moines?

    Currently, March is the cheapest month in which you can book a flight from Louisville to Des Moines (average of $157). Flying from Louisville to Des Moines in December is currently the most expensive (average of $388). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Traveling to a place near Des Moines?

Book flights to Des Moines if you plan to visit one of these locations
Johnston
Altoona
Boone
Ames
West Des Moines
Ankeny

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Top 3 airlines flying from Louisville to Des Moines

Discover the top 3 airlines that operate flights from Louisville to Des Moines. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated October 17, 2025.
AirlineCheapestAverageFlexibilityOn-time
DeltaCheapest$105Average$472FlexibilityNo cancel feeOn-timeN/A
American AirlinesCheapest$158Average$278FlexibilityNo cancel feeOn-time71%
United AirlinesCheapest$246Average$399FlexibilityNo cancel feeOn-time69%

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