$123+ Cheap flights from Louisville to Des Moines (SDF - DSM)
This is the cheapest round-trip flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 11/9. Fares are subject to change and may not be available on all flights or dates of travel.
SDF — DSM
Nov 24 — Dec 11
Round-trip
1 adult, Economy
We work with more than 300 partners to bring you better travel deals
Find cheap flights from Louisville to Des Moines with Cheapflights
1. Tell us where you want to go
Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”2. Select your favorite providers
We find the providers serving your travel needs. Choose up to four travel providers to compare side-by-side for flights, hotels, or car rentals.3. Compare prices and book
Review each provider’s pricing and select the best option for you! Book through your favorite provider’s website for a seamless experience.Cheap flight deals from Louisville to Des Moines
Cheapest
Best
Last-minute
One-way
Cheapest flights from Louisville to Des MoinesExplore the most affordable flight options available from Louisville to Des Moines. Find the lowest fares from popular airlines and budget airlines, with prices last updated on October 25, 2026.
Explore the most affordable flight options available from Louisville to Des Moines. Find the lowest fares from popular airlines and budget airlines, with prices last updated on October 25, 2026.
This Southwest deal was found by Cheapflights users on 10/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 11/207:55 pm -
1 stop4h 10m
Sun 11/225:25 am -
1 stop3h 40m
Deal found 10/21![Southwest logo]()
$320
This United Airlines deal was found by Cheapflights users on 10/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 11/107:00 am -
1 stop4h 32m
Wed 11/111:27 pm -
1 stop7h 57m
Deal found 10/20![United Airlines logo]()
$335
This Delta deal was found by Cheapflights users on 10/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/57:05 am -
1 stop4h 37m
Mon 11/96:52 pm -
1 stop4h 18m
Deal found 10/21![Delta logo]()
$377
This Southwest deal was found by Cheapflights users on 10/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/55:35 pm -
2 stops6h 30m
Mon 11/95:25 am -
1 stop3h 40m
Deal found 10/21![Southwest logo]()
$386
This Kiwi.com deal was found by Cheapflights users on 10/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/299:43 pm -
1 stop11h 42m
Sun 11/111:17 am -
1 stop6h 35m
Deal found 10/21![Allegiant Air logo]()
$389
This Kiwi.com deal was found by Cheapflights users on 10/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/299:43 pm -
1 stop11h 42m
Sun 11/12:49 pm -
2 stops17h 56m
Deal found 10/21![Multiple Airlines logo]()
$452
This American Airlines deal was found by Cheapflights users on 10/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 11/66:31 pm -
1 stop6h 55m
Sun 11/87:23 am -
1 stop4h 20m
Deal found 10/21![American Airlines logo]()
$509
This Southwest deal was found by Cheapflights users on 10/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 11/65:35 pm -
2 stops6h 30m
Sun 11/85:25 am -
1 stop3h 40m
Deal found 10/21![Southwest logo]()
$514
This Southwest deal was found by Cheapflights users on 10/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 11/98:45 am -
1 stop3h 45m
Fri 11/136:40 am -
2 stops13h 25m
Deal found 10/24![Southwest logo]()
$520
Best flights from Louisville to Des MoinesDiscover carefully curated flight deals from Louisville to Des Moines that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated October 25, 2026.
Discover carefully curated flight deals from Louisville to Des Moines that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated October 25, 2026.
This United Airlines deal was found by Cheapflights users on 10/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 1/237:00 am -
1 stop6h 17m
Tue 1/268:00 am -
1 stop5h 47m
Deal found 10/22![United Airlines logo]()
$245
This Southwest deal was found by Cheapflights users on 10/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 11/207:55 pm -
1 stop4h 10m
Sun 11/225:25 am -
1 stop3h 40m
Deal found 10/22![Southwest logo]()
$320
This Delta deal was found by Cheapflights users on 10/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 11/95:59 pm -
1 stop5h 36m
Fri 11/132:48 pm -
1 stop6h 58m
Deal found 10/24![Delta logo]()
$509
This Southwest deal was found by Cheapflights users on 10/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 1/238:00 am -
2 stops13h 15m
Tue 1/263:10 pm -
1 stop3h 40m
Deal found 10/22![Southwest logo]()
$322
This United Airlines deal was found by Cheapflights users on 10/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 11/103:45 pm -
1 stop7h 45m
Wed 11/115:30 am -
1 stop7h 52m
Deal found 10/23![United Airlines logo]()
$335
This Southwest deal was found by Cheapflights users on 10/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/55:35 pm -
2 stops6h 30m
Mon 11/95:25 am -
1 stop3h 40m
Deal found 10/21![Southwest logo]()
$386
This Southwest deal was found by Cheapflights users on 10/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 11/98:45 am -
1 stop3h 45m
Fri 11/136:40 am -
2 stops13h 25m
Deal found 10/24![Southwest logo]()
$520
Last-minute flights from Louisville to Des MoinesDiscover last-minute flight deals from Louisville to Des Moines. Data last updated October 25, 2026 and is based on user searches.
Discover last-minute flight deals from Louisville to Des Moines. Data last updated October 25, 2026 and is based on user searches.
This Kiwi.com deal was found by Cheapflights users on 10/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/299:43 pm -
1 stop11h 42m
Sun 11/111:17 am -
1 stop6h 35m
Deal found 10/21![Allegiant Air logo]()
$389
This Kiwi.com deal was found by Cheapflights users on 10/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/299:43 pm -
1 stop11h 42m
Sun 11/12:49 pm -
2 stops17h 56m
Deal found 10/21![Multiple Airlines logo]()
$452
This Delta deal was found by Cheapflights users on 10/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/57:05 am -
1 stop4h 37m
Mon 11/96:52 pm -
1 stop4h 18m
Deal found 10/21![Delta logo]()
$377
This Southwest deal was found by Cheapflights users on 10/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/55:35 pm -
2 stops6h 30m
Mon 11/95:25 am -
1 stop3h 40m
Deal found 10/21![Southwest logo]()
$386
This American Airlines deal was found by Cheapflights users on 10/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 11/66:31 pm -
1 stop6h 55m
Sun 11/87:23 am -
1 stop4h 20m
Deal found 10/21![American Airlines logo]()
$509
This Southwest deal was found by Cheapflights users on 10/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 11/65:35 pm -
2 stops6h 30m
Sun 11/85:25 am -
1 stop3h 40m
Deal found 10/21![Southwest logo]()
$514
This Southwest deal was found by Cheapflights users on 10/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 11/98:45 am -
1 stop3h 45m
Fri 11/136:40 am -
2 stops13h 25m
Deal found 10/24![Southwest logo]()
$520
This United Airlines deal was found by Cheapflights users on 10/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 11/107:00 am -
1 stop4h 32m
Wed 11/111:27 pm -
1 stop7h 57m
Deal found 10/20![United Airlines logo]()
$335
This Southwest deal was found by Cheapflights users on 10/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 11/207:55 pm -
1 stop4h 10m
Sun 11/225:25 am -
1 stop3h 40m
Deal found 10/21![Southwest logo]()
$320
One-way flights from Louisville to Des MoinesSearch for one-way flight options from Louisville to Des Moines. Find affordable one-way fares based on user searches. Data last updated October 25, 2026.
Search for one-way flight options from Louisville to Des Moines. Find affordable one-way fares based on user searches. Data last updated October 25, 2026.
This Delta deal was found by Cheapflights users on 10/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 11/95:59 pm -
1 stop5h 36m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 10/21![Delta logo]()
$123
This United Airlines deal was found by Cheapflights users on 10/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 4/239:00 am -
1 stop6h 11m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 10/22![United Airlines logo]()
$189
This Southwest deal was found by Cheapflights users on 10/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 4/233:50 pm -
2 stops9h 00m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 10/22![Southwest logo]()
$214
This Delta deal was found by Cheapflights users on 10/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 11/711:06 am -
1 stop5h 10m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 10/21![Delta logo]()
$255
This Southwest deal was found by Cheapflights users on 10/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 11/712:45 pm -
2 stops8h 00m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 10/21![Southwest logo]()
$260
This Kiwi.com deal was found by Cheapflights users on 10/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 11/89:09 pm -
2 stops23h 26m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 10/21![Multiple Airlines logo]()
$267
This Kiwi.com deal was found by Cheapflights users on 10/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 11/96:53 pm -
3 stops44h 02m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 10/21![Multiple Airlines logo]()
$294
This Southwest deal was found by Cheapflights users on 10/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 11/65:35 pm -
2 stops6h 30m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 10/22![Southwest logo]()
$303
This Kiwi.com deal was found by Cheapflights users on 10/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 11/610:25 am -
3 stops50h 10m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 10/22![Multiple Airlines logo]()
$404
This Kiwi.com deal was found by Cheapflights users on 10/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 11/74:06 pm -
3 stops20h 29m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 10/21![Multiple Airlines logo]()
$407
This American Airlines deal was found by Cheapflights users on 10/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 11/912:57 pm -
2 stops9h 23m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 10/21![American Airlines logo]()
$823
This United Airlines deal was found by Cheapflights users on 10/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 11/86:00 am -
3 stops12h 28m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 10/21![United Airlines logo]()
$1,231
Find flight deals from Louisville to Des Moines
Discover tips and strategies to find the most affordable flight options for your journey from Louisville (SDF) to Des Moines (DSM). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated October 25, 2026.
Most accurate provider | FlightHub 3 stars |
|---|---|
Most trusted provider | FlightHub 3 stars |
Round-trip from | $245 (United Airlines) |
One-way from | $123 (Delta) |
Popular in | July |
Cheapest in | September |
Average price | $393 |
Cheapflights Fare Finder
Customize your flight search to find flights from Louisville to Des Moines that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 7,457,451 searches. Data last updated October 25, 2026.
Use the filters below to find and compare flights from Louisville to Des Moines that are best for you.
Fly from
Fly to
Route
Depart
Return
Cheapest round-trip
LouisvilleDes Moines
SDF Louisville Intl - DSM Des Moines
SDFDSM
Louisville Intl
Fri 4/23
9:00 am-2:11 pm
1 stop6h 11m
Des Moines
Wed 12/31
12:00 am-1:00 am
Nonstop0h 00m
$189
LouisvilleDes Moines
SDF Louisville Intl - DSM Des Moines
SDFDSM
Louisville Intl
Sat 1/23
7:00 am-12:17 pm
1 stop6h 17m
Des Moines
Tue 1/26
8:00 am-2:47 pm
1 stop5h 47m
$245
LouisvilleDes Moines
SDF Louisville Intl - DSM Des Moines
SDFDSM
Louisville Intl
Sat 11/7
11:06 am-3:16 pm
1 stop5h 10m
Des Moines
Wed 12/31
12:00 am-1:00 am
Nonstop0h 00m
$255
Quickest round-trip
LouisvilleDes Moines
SDF Louisville Intl - DSM Des Moines
SDFDSM
Louisville Intl
Fri 11/6
8:45 am-11:30 am
1 stop3h 45m
Des Moines
Wed 12/31
12:00 am-1:00 am
Nonstop0h 00m
$255
LouisvilleDes Moines
SDF Louisville Intl - DSM Des Moines
SDFDSM
Louisville Intl
Sat 11/7
10:37 am-2:24 pm
1 stop4h 47m
Des Moines
Wed 12/31
12:00 am-1:00 am
Nonstop0h 00m
$255
LouisvilleDes Moines
SDF Louisville Intl - DSM Des Moines
SDFDSM
Louisville Intl
Sun 11/8
7:00 am-10:32 am
1 stop4h 32m
Des Moines
Wed 12/31
12:00 am-1:00 am
Nonstop0h 00m
$255
LouisvilleDes Moines
SDF Louisville Intl - DSM Des Moines
SDFDSM
Louisville Intl
Sat 11/7
12:45 pm-7:45 pm
2 stops8h 00m
Des Moines
Wed 12/31
12:00 am-1:00 am
Nonstop0h 00m
$260
LouisvilleDes Moines
SDF Louisville Intl - DSM Des Moines
SDFDSM
Louisville Intl
Fri 11/20
7:55 pm-11:05 pm
1 stop4h 10m
Des Moines
Sun 11/22
5:25 am-10:05 am
1 stop3h 40m
$320
LouisvilleDes Moines
SDF Louisville Intl - DSM Des Moines
SDFDSM
Louisville Intl
Sat 1/23
8:00 am-8:15 pm
2 stops13h 15m
Des Moines
Tue 1/26
3:10 pm-7:50 pm
1 stop3h 40m
$322
LouisvilleDes Moines
SDF Louisville Intl - DSM Des Moines
SDFDSM
Louisville Intl
Tue 11/10
3:45 pm-10:30 pm
1 stop7h 45m
Des Moines
Wed 11/11
5:30 am-2:22 pm
1 stop7h 52m
$335
Showing 1-10 of 13 resultsSorted by cheapest first
Compare providers for flights from Louisville to Des Moines
Provider information is updated monthly. Please note that these providers often have deals for this flight, but the availability may vary on a day-by-day basis on Cheapflights.
Use the table below to compare price accuracy, trust ratings, and cancellation policies for each provider offering flight deals from Louisville to Des Moines in October.
| Provider | Price Accuracy | Trust Score* |
|---|---|---|
| Price Accuracy3 stars | Trust Score*3 stars | |
| Price Accuracy1 star | Trust Score*3 stars | |
| Price Accuracy3 stars | Trust Score*3 stars |
- Most accurate provider: When it comes to deals on Louisville-Des Moines flights, users find the pricing of FlightHub to be most consistent on Cheapflights vs. FlightHub Users can find the same prices on Louisville-Des Moines flight deals on Cheapflights vs. FlightHub >95% of the time. Price accuracy is based on data collected from Louisville-Des Moines flight searches over the past month and is updated monthly.
- Most trusted provider: When it comes to deals on Louisville-Des Moines flights, Cheapflights users trust FlightHub the most. FlightHub has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for Louisville-Des Moines flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.
Best time to book a flight from Louisville to Des Moines
Have a flexible travel schedule? Discover the best time to fly to Des Moines from Louisville with our price prediction graph.
SDF-DSM
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.
Cheapflights Insights
Everything you need to know about your flight from Louisville to Des Moines
Reviews of airlines servicing Des Moines
Get insights into the airlines that provide service to Des Moines. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Des Moines. Reviews last updated October 25, 2026.
Read through reviews of airlines operating flights from Louisville to Des Moines, such as Delta. Reviews also offer insight into each airline's entertainment options, comfort, food, crew/service, and boarding process.
Crew
8.5
Boarding
8.1
Overall
7.8
Comfort
7.8
Entertainment
7.8
Food
7.2
Reviews
1 / 20
6.0
GoodEllen,Oct 2026
GRR - ATL
Crew
8.5
Boarding
8.1
Overall
7.8
Comfort
7.8
Entertainment
7.8
Food
7.2
Reviews
1 / 20
6.0
GoodEllen,Oct 2026
GRR - ATL
Related info for your journey
Find useful and relevant information for your journey from Louisville to Des Moines. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.
Traveling to a place near Des Moines?
Book flights to Des Moines if you plan to visit one of these locationsAltoona
Clive
West Des Moines
Ames
Johnston
Boone
Norwalk
Ankeny
Browse thousands of different options on Cheapflights for your next trip
Toggle through the tabs below to find thousands of options on Cheapflights for your next trip.
Alternative routes
Complete your trip
Des Moines flight routes
Flights by cabin class
Other flight options
Other flights from Louisville
Popular flights
Alternative routes for Louisville to Des Moines
See prices for flight routes from nearby airports that may be better suited for you.
Complete your trip
Complete your trip to Des Moines by adding a car rental and/or hotel reservation to your travel itinerary.
Other flights to Des Moines
Explore flights to Des Moines departing from other origins. Flights are based on user searches made on Cheapflights and were last updated on October 25, 2026.
Search flights from Louisville to Des Moines by cabin class
Find flights from Louisville to Des Moines, based on your preferred cabin class, be it economy, premium economy, business, or first class.
Louisville and Des Moines flights
Browse other Louisville and Des Moines flight options. Last updated on October 25, 2026.
Other flights from Louisville
Browse through other flights departing from Louisville. Flights are based on user searches made on Cheapflights and were last updated on October 25, 2026.
Popular flight searches
Check out other popular destinations found by fellow travelers in 2026
Top airline flying from Louisville to Des Moines
Discover the top airline that operate flights from Louisville to Des Moines. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 7,457,451 searches. Data last updated October 25, 2026.
| Airline | Cheapest | Average | Flexibility | On-time |
|---|---|---|---|---|
| Cheapest$233 | Average$346 | FlexibilityNo cancel fee | On-timeN/A |