HomeSearch by dateVacation packagesHotelsFlight dealsCar rentalTravel tips & news
Des Moines

$146+ Cheap flights from Louisville to Des Moines (SDF - DSM)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 4/2. Fares are subject to change and may not be available on all flights or dates of travel.
SDF — DSM
Apr 15 — Apr 221
Wed 4/15
Wed 4/22
1 adult, Economy
We work with more than 300 partners to bring you better travel deals

Find cheap flights from Louisville to Des Moines with Cheapflights

1. Tell us where you want to go

Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”

2. Select your favorite providers

We find the providers serving your travel needs. Choose up to four travel providers to compare side-by-side for flights, hotels, or car rentals.

3. Compare prices and book

Review each provider’s pricing and select the best option for you! Book through your favorite provider’s website for a seamless experience.

Cheap flight deals from Louisville to Des Moines

Cheapest flights from Louisville to Des Moines
Explore the most affordable flight options available from Louisville to Des Moines. Find the lowest fares from popular airlines and budget airlines, with prices last updated on March 16, 2026.

This American Airlines deal was found by Cheapflights users on 3/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 4/27:00 am
SDF
-
DSM
1 stop7h 07m
American Airlines
Sat 4/41:37 pm
DSM
-
SDF
1 stop6h 49m
American Airlines
Deal found 3/12$291
This Delta deal was found by Cheapflights users on 3/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 4/26:15 am
SDF
-
DSM
1 stop4h 54m
Delta
Sun 4/56:55 am
DSM
-
SDF
1 stop3h 56m
Delta
Deal found 3/12$339
This United Airlines deal was found by Cheapflights users on 3/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 4/117:20 am
SDF
-
DSM
1 stop4h 24m
United Airlines
Tue 4/147:16 pm
DSM
-
SDF
1 stop3h 43m
United Airlines
Deal found 3/12$341
This American Airlines deal was found by Cheapflights users on 3/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 4/27:00 am
SDF
-
DSM
1 stop7h 07m
American Airlines
Sun 4/510:04 am
DSM
-
SDF
2 stops8h 03m
American Airlines
Deal found 3/12$344
This Southwest deal was found by Cheapflights users on 3/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 4/28:10 pm
SDF
-
DSM
1 stop4h 05m
Southwest
Sat 4/45:20 am
DSM
-
SDF
2 stops6h 40m
Southwest
Deal found 3/12$354
This Southwest deal was found by Cheapflights users on 3/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 7/158:45 am
SDF
-
DSM
1 stop3h 45m
Southwest
Mon 7/205:10 am
DSM
-
SDF
1 stop3h 55m
Southwest
Deal found 3/15$367
This American Airlines deal was found by Cheapflights users on 3/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 5/298:15 am
SDF
-
DSM
1 stop5h 37m
American Airlines
Sun 6/75:00 am
DSM
-
SDF
1 stop4h 17m
American Airlines
Deal found 3/12$387
This American Airlines deal was found by Cheapflights users on 3/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 4/287:01 pm
SDF
-
DSM
1 stop5h 48m
American Airlines
Wed 4/295:44 am
DSM
-
SDF
1 stop4h 02m
American Airlines
Deal found 3/11$405

Find flight deals from Louisville to Des Moines

Discover tips and strategies to find the most affordable flight options for your journey from Louisville (SDF) to Des Moines (DSM). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated March 16, 2026.

Most accurate provider

FlightHub
3 stars

Most trusted provider

FlightHub
3 stars

Round-trip from

$291
(American Airlines)

One-way from

$146
(Delta)
Provider with most accurate pricing for Louisville Intl-Des Moines flight deals.
Search Deals
Provider most trusted by Cheapflights users for Louisville Intl-Des Moines flights.
Search Deals
From Louisville Intl to Des Moines
Search Deals
One-way flight from Louisville Intl to Des Moines
Search Deals

Cheapflights Fare Finder

 
Customize your flight search to find flights from Louisville to Des Moines that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated March 16, 2026.
Use the filters below to find and compare flights from Louisville to Des Moines that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Cheapest round-trip

LouisvilleDes Moines

SDF - DSM

SDFDSM

Louisville Intl

Thu 4/2

6:15 am-10:09 am

1 stop4h 54m

Des Moines

Sun 4/5

6:55 am-11:51 am

1 stop3h 56m

$339

LouisvilleDes Moines

SDF - DSM

SDFDSM

Louisville Intl

Sat 4/11

9:07 am-2:28 pm

1 stop6h 21m

Des Moines

Tue 4/14

3:04 pm-9:59 pm

1 stop5h 55m

$341
Quickest round-trip

LouisvilleDes Moines

SDF - DSM

SDFDSM

Louisville Intl

Wed 7/15

8:45 am-11:30 am

1 stop3h 45m

Des Moines

Mon 7/20

5:10 am-10:05 am

1 stop3h 55m

$367

LouisvilleDes Moines

SDF - DSM

SDFDSM

Louisville Intl

Tue 4/28

7:01 pm-11:49 pm

1 stop5h 48m

Des Moines

Wed 4/29

5:44 am-10:46 am

1 stop4h 02m

$405

LouisvilleDes Moines

SDF - DSM

SDFDSM

Louisville Intl

Thu 4/2

6:35 am-12:10 pm

2 stops6h 35m

Des Moines

Sun 4/5

5:25 am-3:15 pm

2 stops8h 50m

$407

LouisvilleDes Moines

SDF - DSM

SDFDSM

Louisville Intl

Mon 4/27

6:00 am-11:30 am

1 stop6h 30m

Des Moines

Wed 4/29

5:44 am-10:46 am

1 stop4h 02m

$415

LouisvilleDes Moines

SDF - DSM

SDFDSM

Louisville Intl

Mon 4/27

11:16 am-10:42 pm

2 stops12h 26m

Des Moines

Thu 4/30

2:36 pm-6:58 pm

1 stop27h 22m

$447

LouisvilleDes Moines

SDF - DSM

SDFDSM

Louisville Intl

Tue 3/31

8:55 am-11:40 am

1 stop3h 45m

Des Moines

Sat 4/4

4:35 pm-9:30 pm

1 stop3h 55m

$447

LouisvilleDes Moines

SDF - DSM

SDFDSM

Louisville Intl

Fri 3/27

8:35 am-12:10 pm

1 stop4h 35m

Des Moines

Mon 3/30

5:35 am-9:55 am

1 stop3h 20m

$447
Cheapest one-way
Quickest one-way

LouisvilleDes Moines

SDF - DSM

SDFDSM

Louisville Intl

Thu 4/2

6:15 am-10:09 am

1 stop4h 54m

$146

Flights are sorted by cheapest round-trip flights first.

Deals found on 3/12

Showing 1-10 of 18 resultsSorted by cheapest first
1
2

Compare providers for flights from Louisville to Des Moines

Provider information is updated monthly. Please note that these providers often have deals for this flight, but the availability may vary on a day-by-day basis on Cheapflights.
Use the table below to compare price accuracy, trust ratings, and cancellation policies for each provider offering flight deals from Louisville to Des Moines in March.
ProviderPrice AccuracyTrust Score*
FlightHubPrice Accuracy3 starsTrust Score*3 stars
ExpediaPrice Accuracy1 starTrust Score*3 stars
MytripPrice Accuracy3 starsTrust Score*3 stars

*The Trust Score is based on feedback from users after their booking experience. It measures overall satisfaction, helping us identify issues like hidden fees, problems during the ticketing process, and the quality of customer service. This score is our best indicator of the provider's quality and reliability.

  • Most accurate provider: When it comes to deals on Louisville-Des Moines flights, users find the pricing of FlightHub to be most consistent on Cheapflights vs. FlightHub Users can find the same prices on Louisville-Des Moines flight deals on Cheapflights vs. FlightHub >95% of the time. Price accuracy is based on data collected from Louisville-Des Moines flight searches over the past month and is updated monthly.
  • Most trusted provider: When it comes to deals on Louisville-Des Moines flights, Cheapflights users trust FlightHub the most. FlightHub has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for Louisville-Des Moines flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.

Best time to book a flight from Louisville to Des Moines

Have a flexible travel schedule? Discover the best time to fly to Des Moines from Louisville with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Louisville to Des Moines

What is the cheapest month to book a flight from Louisville to Des Moines?

Currently, September is the cheapest month in which you can book a flight from Louisville to Des Moines (average of $236). Flying from Louisville to Des Moines in February is currently the most expensive (average of $524). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

Reviews of airlines servicing Des Moines

Get insights into the airlines that provide service to Des Moines. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Des Moines. Reviews last updated March 16, 2026.
Read through reviews of airlines operating flights from Louisville to Des Moines, such as Delta,United Airlines, andAmerican Airlines. Reviews also offer insight into each airline's entertainment options, comfort, food, crew/service, and boarding process.
Delta
7.9
Good
8,296 reviews

Food

7.2

Crew

8.5

Overall

7.9

Entertainment

7.8

Boarding

8.1

Comfort

7.9

Reviews

1 / 20
6.0
Good

Jim,Nov 2025

AVL - ATL

The exit row seats without a seat in front are great for leg room but don’t have a fold out entertainment console so you’re forced to use the screen several feet in front of you (there is, at least, a remote). Best to bring a tablet loaded with entertainment or a book.
Delta
7.9
Good
8,296 reviews
Delta
7.9
Good
8,296 reviews

Food

7.2

Crew

8.5

Overall

7.9

Entertainment

7.8

Boarding

8.1

Comfort

7.9

Reviews

1 / 20
6.0
Good

Jim,Nov 2025

AVL - ATL

The exit row seats without a seat in front are great for leg room but don’t have a fold out entertainment console so you’re forced to use the screen several feet in front of you (there is, at least, a remote). Best to bring a tablet loaded with entertainment or a book.
United Airlines
7.4
Good
9,428 reviews
Delta
7.9
Good
8,296 reviews

Food

7.2

Crew

8.5

Overall

7.9

Entertainment

7.8

Boarding

8.1

Comfort

7.9

Reviews

1 / 20
6.0
Good

Jim,Nov 2025

AVL - ATL

The exit row seats without a seat in front are great for leg room but don’t have a fold out entertainment console so you’re forced to use the screen several feet in front of you (there is, at least, a remote). Best to bring a tablet loaded with entertainment or a book.
American Airlines
7.1
Good
11,467 reviews
Delta
7.9
Good
8,296 reviews

Food

7.2

Crew

8.5

Overall

7.9

Entertainment

7.8

Boarding

8.1

Comfort

7.9

Reviews

1 / 20
6.0
Good

Jim,Nov 2025

AVL - ATL

The exit row seats without a seat in front are great for leg room but don’t have a fold out entertainment console so you’re forced to use the screen several feet in front of you (there is, at least, a remote). Best to bring a tablet loaded with entertainment or a book.

Related info for your journey

Find useful and relevant information for your journey from Louisville to Des Moines. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • How long is the flight from Louisville to Des Moines?

    For as low as $367, Delta can have you in Des Moines from Louisville in 3h 45m. Airlines will cover a distance of 480 mi. Both multi-stop and nonstop flights can be found to your destination and back.

  • What are the cheapest airlines flying from Louisville to Des Moines round-trip?

    Flying on Delta is currently your cheapest option to Des Moines, with prices starting at $105. Additional round-trip tickets that might be worth considering are offered by American Airlines and United Airlines, with the lowest prices starting at $158 and $248, respectively.

  • Can I find deals for flights from Louisville to Des Moines that include hotel bookings?

    Yes. In addition to deals on Louisville to Des Moines flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Louisville to Des Moines?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Louisville to Des Moines.

  • Can I find deals for business class flights from Louisville to Des Moines?

    Yes. Cheapflights offers flight deals from Louisville to Des Moines by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Louisville to Des Moines?

    Currently, September is the cheapest month in which you can book a flight from Louisville to Des Moines (average of $236). Flying from Louisville to Des Moines in February is currently the most expensive (average of $524). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Traveling to a place near Des Moines?

Book flights to Des Moines if you plan to visit one of these locations
Altoona
Johnston
Ankeny
Ames
Boone
Clive
West Des Moines

Browse thousands of different options on Cheapflights for your next trip

Toggle through the tabs below to find thousands of options on Cheapflights for your next trip.

Top 3 airlines flying from Louisville to Des Moines

Discover the top 3 airlines that operate flights from Louisville to Des Moines. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated March 16, 2026.
AirlineCheapestAverageFlexibilityOn-time
DeltaCheapest$105Average$276FlexibilityNo cancel feeOn-timeN/A
American AirlinesCheapest$158Average$241FlexibilityNo cancel feeOn-time71%
United AirlinesCheapest$248Average$456FlexibilityNo cancel feeOn-time69%

100% Free

Cheapflights is completely free to use, so you can start saving the moment you arrive.

Book with Flexibility

Our users can plan ahead with confidence and find flights with no change fees

Travel Smart

Millions of people come to us for their flight needs every year. We help make travel planning easy by providing useful insights and data-driven graphs that can inform your decisions.