$156+ Cheap flights from Louisville to Des Moines (SDF - DSM)
This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 5/23. Fares are subject to change and may not be available on all flights or dates of travel.
SDF — DSM
May 30 — Jun 61
Round-trip
1 adult, Economy
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Find cheap flights from Louisville to Des Moines with Cheapflights
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Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”2. Select your favorite providers
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Cheapest flights from Louisville to Des MoinesExplore the most affordable flight options available from Louisville to Des Moines. Find the lowest fares from popular airlines and budget airlines, with prices last updated on April 30, 2026.
Explore the most affordable flight options available from Louisville to Des Moines. Find the lowest fares from popular airlines and budget airlines, with prices last updated on April 30, 2026.
This Delta deal was found by Cheapflights users on 4/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 5/206:05 am
SDF
- DSM
1 stop5h 11m
Delta
Sat 5/2312:29 pm
DSM
- SDF
1 stop3h 43m
Delta
Deal found 4/26![Delta logo]()
$299
This American Airlines deal was found by Cheapflights users on 4/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 5/207:55 pm
SDF
- DSM
1 stop5h 04m
American Airlines
Sat 5/231:48 pm
DSM
- SDF
2 stops7h 38m
American Airlines
Deal found 4/26![American Airlines logo]()
$304
This Delta deal was found by Cheapflights users on 4/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 5/215:52 pm
SDF
- DSM
1 stop3h 44m
Delta
Mon 5/256:15 am
DSM
- SDF
1 stop6h 36m
Delta
Deal found 4/29![Delta logo]()
$311
This Delta deal was found by Cheapflights users on 4/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 6/212:42 pm
SDF
- DSM
1 stop5h 24m
Delta
Fri 6/56:41 pm
DSM
- SDF
1 stop4h 44m
Delta
Deal found 4/27![Delta logo]()
$317
This Delta deal was found by Cheapflights users on 4/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 6/16:00 am
SDF
- DSM
1 stop6h 08m
Delta
Fri 6/56:41 pm
DSM
- SDF
1 stop4h 44m
Delta
Deal found 4/27![Delta logo]()
$329
This American Airlines deal was found by Cheapflights users on 4/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 6/67:48 pm
SDF
- DSM
1 stop5h 10m
American Airlines
Mon 6/84:48 pm
DSM
- SDF
1 stop5h 31m
American Airlines
Deal found 4/28![American Airlines logo]()
$339
This Delta deal was found by Cheapflights users on 4/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 5/297:08 am
SDF
- DSM
1 stop5h 00m
Delta
Sun 6/76:39 pm
DSM
- SDF
1 stop4h 53m
Delta
Deal found 4/25![Delta logo]()
$347
This Delta deal was found by Cheapflights users on 4/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 5/165:52 pm
SDF
- DSM
1 stop3h 44m
Delta
Mon 5/181:04 pm
DSM
- SDF
1 stop5h 04m
Delta
Deal found 4/26![Delta logo]()
$349
This United Airlines deal was found by Cheapflights users on 4/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 8/189:00 am
SDF
- DSM
1 stop6h 05m
United Airlines
Wed 8/195:50 am
DSM
- SDF
1 stop7h 29m
United Airlines
Deal found 4/29![United Airlines logo]()
$357
This Southwest deal was found by Cheapflights users on 4/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 6/98:45 am
SDF
- DSM
1 stop3h 45m
Southwest
Thu 6/111:30 pm
DSM
- SDF
2 stops7h 55m
Southwest
Deal found 4/26![Southwest logo]()
$364
This American Airlines deal was found by Cheapflights users on 4/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 5/295:43 pm
SDF
- DSM
1 stop7h 34m
American Airlines
Sun 6/75:00 am
DSM
- SDF
1 stop4h 35m
American Airlines
Deal found 4/29![American Airlines logo]()
$367
This Southwest deal was found by Cheapflights users on 4/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 5/203:45 pm
SDF
- DSM
2 stops7h 25m
Southwest
Sat 5/235:35 am
DSM
- SDF
2 stops9h 40m
Southwest
Deal found 4/26![Southwest logo]()
$376
Best flights from Louisville to Des MoinesDiscover carefully curated flight deals from Louisville to Des Moines that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated April 30, 2026.
Discover carefully curated flight deals from Louisville to Des Moines that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated April 30, 2026.
This Delta deal was found by Cheapflights users on 4/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 5/215:52 pm
SDF
- DSM
1 stop3h 44m
Delta
Mon 5/256:15 am
DSM
- SDF
1 stop6h 36m
Delta
Deal found 4/29![Delta logo]()
$311
This American Airlines deal was found by Cheapflights users on 4/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 5/295:43 pm
SDF
- DSM
1 stop7h 34m
American Airlines
Sun 6/75:00 am
DSM
- SDF
1 stop4h 35m
American Airlines
Deal found 4/28![American Airlines logo]()
$367
This Southwest deal was found by Cheapflights users on 4/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 6/95:35 am
SDF
- DSM
2 stops18h 10m
Southwest
Thu 6/114:40 pm
DSM
- SDF
2 stops6h 45m
Southwest
Deal found 4/26![Southwest logo]()
$399
This United Airlines deal was found by Cheapflights users on 4/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 5/165:40 am
SDF
- DSM
1 stop5h 57m
United Airlines
Mon 5/183:20 pm
DSM
- SDF
1 stop6h 10m
United Airlines
Deal found 4/29![United Airlines logo]()
$459
This Delta deal was found by Cheapflights users on 4/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 6/96:34 pm
SDF
- DSM
1 stop4h 57m
Delta
Thu 6/116:50 am
DSM
- SDF
1 stop4h 07m
Delta
Deal found 4/26![Delta logo]()
$317
This Delta deal was found by Cheapflights users on 4/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 5/165:52 pm
SDF
- DSM
1 stop3h 44m
Delta
Mon 5/181:04 pm
DSM
- SDF
1 stop5h 04m
Delta
Deal found 4/26![Delta logo]()
$349
This Southwest deal was found by Cheapflights users on 4/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 5/215:25 pm
SDF
- DSM
2 stops6h 40m
Southwest
Mon 5/255:25 am
DSM
- SDF
1 stop3h 30m
Southwest
Deal found 4/29![Southwest logo]()
$399
This Delta deal was found by Cheapflights users on 4/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 5/151:05 pm
SDF
- DSM
1 stop5h 48m
Delta
Mon 5/181:04 pm
DSM
- SDF
1 stop5h 04m
Delta
Deal found 4/27![Delta logo]()
$385
This Southwest deal was found by Cheapflights users on 4/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 6/69:00 am
SDF
- DSM
2 stops14h 50m
Southwest
Mon 6/81:30 pm
DSM
- SDF
2 stops7h 55m
Southwest
Deal found 4/28![Southwest logo]()
$445
This Southwest deal was found by Cheapflights users on 4/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 5/118:10 pm
SDF
- DSM
1 stop3h 55m
Southwest
Fri 5/155:25 am
DSM
- SDF
1 stop3h 30m
Southwest
Deal found 4/26![Southwest logo]()
$459
This Delta deal was found by Cheapflights users on 4/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 5/163:29 pm
SDF
- DSM
1 stop5h 53m
Delta
Sun 5/177:01 am
DSM
- SDF
1 stop3h 58m
Delta
Deal found 4/27![Delta logo]()
$459
Last-minute flights from Louisville to Des MoinesDiscover last-minute flight deals from Louisville to Des Moines. Data last updated April 30, 2026 and is based on user searches.
Discover last-minute flight deals from Louisville to Des Moines. Data last updated April 30, 2026 and is based on user searches.
This Southwest deal was found by Cheapflights users on 4/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 5/118:10 pm
SDF
- DSM
1 stop3h 55m
Southwest
Fri 5/155:25 am
DSM
- SDF
2 stops10h 25m
Southwest
Deal found 4/26![Southwest logo]()
$464
This Delta deal was found by Cheapflights users on 4/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 5/151:05 pm
SDF
- DSM
1 stop5h 48m
Delta
Mon 5/181:04 pm
DSM
- SDF
1 stop5h 04m
Delta
Deal found 4/27![Delta logo]()
$385
This Delta deal was found by Cheapflights users on 4/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 5/165:52 pm
SDF
- DSM
1 stop3h 44m
Delta
Mon 5/181:04 pm
DSM
- SDF
1 stop5h 04m
Delta
Deal found 4/26![Delta logo]()
$349
This Delta deal was found by Cheapflights users on 4/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 5/163:29 pm
SDF
- DSM
1 stop5h 53m
Delta
Sun 5/177:01 am
DSM
- SDF
1 stop3h 58m
Delta
Deal found 4/27![Delta logo]()
$459
This Delta deal was found by Cheapflights users on 4/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 5/206:05 am
SDF
- DSM
1 stop5h 11m
Delta
Sat 5/2312:29 pm
DSM
- SDF
1 stop3h 43m
Delta
Deal found 4/26![Delta logo]()
$299
This American Airlines deal was found by Cheapflights users on 4/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 5/207:55 pm
SDF
- DSM
1 stop5h 04m
American Airlines
Sat 5/231:48 pm
DSM
- SDF
2 stops7h 38m
American Airlines
Deal found 4/26![American Airlines logo]()
$304
This Southwest deal was found by Cheapflights users on 4/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 5/203:45 pm
SDF
- DSM
2 stops7h 25m
Southwest
Sat 5/235:35 am
DSM
- SDF
2 stops9h 40m
Southwest
Deal found 4/26![Southwest logo]()
$376
This Delta deal was found by Cheapflights users on 4/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 5/215:52 pm
SDF
- DSM
1 stop3h 44m
Delta
Mon 5/256:15 am
DSM
- SDF
1 stop6h 36m
Delta
Deal found 4/29![Delta logo]()
$311
This Southwest deal was found by Cheapflights users on 4/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 5/215:25 pm
SDF
- DSM
2 stops6h 40m
Southwest
Mon 5/255:25 am
DSM
- SDF
1 stop3h 30m
Southwest
Deal found 4/29![Southwest logo]()
$399
This Delta deal was found by Cheapflights users on 4/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 5/297:08 am
SDF
- DSM
1 stop5h 00m
Delta
Sun 6/76:39 pm
DSM
- SDF
1 stop4h 53m
Delta
Deal found 4/25![Delta logo]()
$347
This American Airlines deal was found by Cheapflights users on 4/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 5/295:43 pm
SDF
- DSM
1 stop7h 34m
American Airlines
Sun 6/75:00 am
DSM
- SDF
1 stop4h 35m
American Airlines
Deal found 4/29![American Airlines logo]()
$367
One-way flights from Louisville to Des MoinesSearch for one-way flight options from Louisville to Des Moines. Find affordable one-way fares based on user searches. Data last updated April 30, 2026.
Search for one-way flight options from Louisville to Des Moines. Find affordable one-way fares based on user searches. Data last updated April 30, 2026.
This Delta deal was found by Cheapflights users on 4/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 5/2310:39 am
SDF
- DSM
1 stop7h 09m
Delta
Deal found 4/25![Delta logo]()
$156
This American Airlines deal was found by Cheapflights users on 4/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 5/235:43 pm
SDF
- DSM
2 stops7h 29m
American Airlines
Deal found 4/25![American Airlines logo]()
$161
This Delta deal was found by Cheapflights users on 4/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 5/222:34 pm
SDF
- DSM
1 stop7h 02m
Delta
Deal found 4/28![Delta logo]()
$194
This United Airlines deal was found by Cheapflights users on 4/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 5/145:40 am
SDF
- DSM
1 stop4h 43m
United Airlines
Deal found 4/29![United Airlines logo]()
$222
This KAYAK deal was found by Cheapflights users on 4/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure KAYAK is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 5/147:08 am
SDF
- DSM
1 stop5h 00m
Delta
Deal found 4/29![Delta logo]()
$265
This American Airlines deal was found by Cheapflights users on 4/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 6/227:18 pm
SDF
- DSM
1 stop6h 17m
American Airlines
Deal found 4/27![American Airlines logo]()
$296
This Delta deal was found by Cheapflights users on 4/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 5/51:00 pm
SDF
- DSM
1 stop5h 45m
Delta
Deal found 4/25![Delta logo]()
$309
This Southwest deal was found by Cheapflights users on 4/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 5/53:45 pm
SDF
- DSM
2 stops7h 25m
Southwest
Deal found 4/25![Southwest logo]()
$314
This United Airlines deal was found by Cheapflights users on 4/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 5/227:52 pm
SDF
- DSM
2 stops27h 43m
United Airlines
Deal found 4/28![United Airlines logo]()
$410
This United Airlines deal was found by Cheapflights users on 4/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 5/235:46 pm
SDF
- DSM
3 stops19h 50m
United Airlines
Deal found 4/25![United Airlines logo]()
$450
This United Airlines deal was found by Cheapflights users on 4/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 6/226:00 am
SDF
- DSM
2 stops16h 40m
United Airlines
Deal found 4/27![United Airlines logo]()
$614
This United Airlines deal was found by Cheapflights users on 4/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 5/55:36 am
SDF
- DSM
3 stops15h 40m
United Airlines
Deal found 4/25![United Airlines logo]()
$937
Find flight deals from Louisville to Des Moines
Discover tips and strategies to find the most affordable flight options for your journey from Louisville (SDF) to Des Moines (DSM). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated April 30, 2026.
Most accurate provider | FlightHub 3 stars |
|---|---|
Most trusted provider | FlightHub 3 stars |
Round-trip from | $299 (Delta) |
One-way from | $156 (Delta) |
Cheapflights Fare Finder
Customize your flight search to find flights from Louisville to Des Moines that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated April 30, 2026.
Use the filters below to find and compare flights from Louisville to Des Moines that are best for you.
Fly from
Fly to
Route
Depart
Return
Cheapest round-trip
LouisvilleDes Moines
SDF - DSM
SDFDSM
Louisville Intl
Thu 5/21
5:52 pm-8:36 pm
1 stop3h 44m
Des Moines
Mon 5/25
6:15 am-1:51 pm
1 stop6h 36m
$311
LouisvilleDes Moines
SDF - DSM
SDFDSM
Louisville Intl
Tue 6/9
6:34 pm-10:31 pm
1 stop4h 57m
Des Moines
Thu 6/11
6:50 am-11:57 am
1 stop4h 07m
$317
LouisvilleDes Moines
SDF - DSM
SDFDSM
Louisville Intl
Sat 5/16
5:52 pm-8:36 pm
1 stop3h 44m
Des Moines
Mon 5/18
1:04 pm-7:08 pm
1 stop5h 04m
$349
LouisvilleDes Moines
SDF - DSM
SDFDSM
Louisville Intl
Fri 5/29
5:43 pm-12:17 am
1 stop7h 34m
Des Moines
Sun 6/7
5:00 am-10:35 am
1 stop4h 35m
$367
LouisvilleDes Moines
SDF - DSM
SDFDSM
Louisville Intl
Fri 5/15
1:05 pm-5:53 pm
1 stop5h 48m
Des Moines
Mon 5/18
1:04 pm-7:08 pm
1 stop5h 04m
$385
LouisvilleDes Moines
SDF - DSM
SDFDSM
Louisville Intl
Tue 6/9
5:35 am-10:45 pm
2 stops18h 10m
Des Moines
Thu 6/11
4:40 pm-12:25 am
2 stops6h 45m
$399
LouisvilleDes Moines
SDF - DSM
SDFDSM
Louisville Intl
Thu 5/21
5:25 pm-11:05 pm
2 stops6h 40m
Des Moines
Mon 5/25
5:25 am-9:55 am
1 stop3h 30m
$399
LouisvilleDes Moines
SDF - DSM
SDFDSM
Louisville Intl
Sat 6/6
9:00 am-10:50 pm
2 stops14h 50m
Des Moines
Mon 6/8
1:30 pm-10:25 pm
2 stops7h 55m
$445
LouisvilleDes Moines
SDF - DSM
SDFDSM
Louisville Intl
Sat 5/16
5:40 am-10:37 am
1 stop5h 57m
Des Moines
Mon 5/18
3:20 pm-10:30 pm
1 stop6h 10m
$459
Quickest round-trip
LouisvilleDes Moines
SDF - DSM
SDFDSM
Louisville Intl
Mon 5/11
8:10 pm-11:05 pm
1 stop3h 55m
Des Moines
Fri 5/15
5:25 am-9:55 am
1 stop3h 30m
$459
Showing 1-10 of 19 resultsSorted by cheapest first
Compare providers for flights from Louisville to Des Moines
Provider information is updated monthly. Please note that these providers often have deals for this flight, but the availability may vary on a day-by-day basis on Cheapflights.
Use the table below to compare price accuracy, trust ratings, and cancellation policies for each provider offering flight deals from Louisville to Des Moines in April.
| Provider | Price Accuracy | Trust Score* |
|---|---|---|
| Price Accuracy1 star | Trust Score*3 stars | |
| Price Accuracy3 stars | Trust Score*3 stars | |
| Price Accuracy3 stars | Trust Score*3 stars |
- Most accurate provider: When it comes to deals on Louisville-Des Moines flights, users find the pricing of FlightHub to be most consistent on Cheapflights vs. FlightHub Users can find the same prices on Louisville-Des Moines flight deals on Cheapflights vs. FlightHub >95% of the time. Price accuracy is based on data collected from Louisville-Des Moines flight searches over the past month and is updated monthly.
- Most trusted provider: When it comes to deals on Louisville-Des Moines flights, Cheapflights users trust FlightHub the most. FlightHub has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for Louisville-Des Moines flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.
Best time to book a flight from Louisville to Des Moines
Have a flexible travel schedule? Discover the best time to fly to Des Moines from Louisville with our price prediction graph.
SDF-DSM
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.
Reviews of airlines servicing Des Moines
Get insights into the airlines that provide service to Des Moines. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Des Moines. Reviews last updated April 30, 2026.
Read through reviews of airlines operating flights from Louisville to Des Moines, such as Delta,United Airlines, andAmerican Airlines. Reviews also offer insight into each airline's entertainment options, comfort, food, crew/service, and boarding process.
Overall
7.9
Comfort
7.9
Entertainment
7.8
Food
7.2
Boarding
8.1
Crew
8.5
Reviews
1 / 20
6.0
GoodJim,Nov 2025
AVL - ATL
Overall
7.9
Comfort
7.9
Entertainment
7.8
Food
7.2
Boarding
8.1
Crew
8.5
Reviews
1 / 20
6.0
GoodJim,Nov 2025
AVL - ATL
Overall
7.9
Comfort
7.9
Entertainment
7.8
Food
7.2
Boarding
8.1
Crew
8.5
Reviews
1 / 20
6.0
GoodJim,Nov 2025
AVL - ATL
Overall
7.9
Comfort
7.9
Entertainment
7.8
Food
7.2
Boarding
8.1
Crew
8.5
Reviews
1 / 20
6.0
GoodJim,Nov 2025
AVL - ATL
Related info for your journey
Find useful and relevant information for your journey from Louisville to Des Moines. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.
Traveling to a place near Des Moines?
Book flights to Des Moines if you plan to visit one of these locationsAltoona
Johnston
Ames
Clive
Boone
West Des Moines
Ankeny
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Other flights to Des Moines
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Louisville and Des Moines flights
Browse other Louisville and Des Moines flight options. Last updated on April 30, 2026.
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Top 3 airlines flying from Louisville to Des Moines
Discover the top 3 airlines that operate flights from Louisville to Des Moines. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated April 30, 2026.
| Airline | Cheapest | Average | Flexibility | On-time |
|---|---|---|---|---|
| Cheapest$105 | Average$276 | FlexibilityNo cancel fee | On-timeN/A | |
| Cheapest$158 | Average$241 | FlexibilityNo cancel fee | On-time71% | |
| Cheapest$248 | Average$386 | FlexibilityNo cancel fee | On-time69% |