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Des Moines

$126+ Cheap flights from Louisville to Des Moines (SDF - DSM)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 2/14. Fares are subject to change and may not be available on all flights or dates of travel.
SDF — DSM
Feb 20 — Feb 271
Fri 2/20
Fri 2/27
1 adult, Economy
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Cheap flight deals from Louisville to Des Moines

Cheapest flights from Louisville to Des Moines
Explore the most affordable flight options available from Louisville to Des Moines. Find the lowest fares from popular airlines and budget airlines, with prices last updated on January 21, 2026.

This Delta deal was found by Cheapflights users on 1/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 3/265:55 pm
SDF
-
DSM
1 stop3h 50m
Delta
Mon 3/305:20 pm
DSM
-
SDF
1 stop4h 23m
Delta
Deal found 1/20$289
This United Airlines deal was found by Cheapflights users on 1/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 2/145:54 pm
SDF
-
DSM
1 stop4h 47m
United Airlines
Sun 2/153:24 pm
DSM
-
SDF
1 stop5h 49m
United Airlines
Deal found 1/20$299
This American Airlines deal was found by Cheapflights users on 1/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 2/145:00 am
SDF
-
DSM
2 stops9h 05m
American Airlines
Sun 2/156:32 am
DSM
-
SDF
1 stop3h 58m
American Airlines
Deal found 1/20$304
This United Airlines deal was found by Cheapflights users on 1/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 2/149:00 am
SDF
-
DSM
1 stop6h 27m
United Airlines
Wed 2/183:24 pm
DSM
-
SDF
1 stop3h 45m
United Airlines
Deal found 1/21$311
This Southwest deal was found by Cheapflights users on 1/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 3/176:35 am
SDF
-
DSM
2 stops16h 30m
Southwest
Sun 3/224:40 pm
DSM
-
SDF
1 stop3h 30m
Southwest
Deal found 1/21$336
This American Airlines deal was found by Cheapflights users on 1/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 9/254:29 pm
SDF
-
DSM
1 stop8h 36m
American Airlines
Sun 9/276:00 am
DSM
-
SDF
1 stop5h 45m
American Airlines
Deal found 1/20$347
This American Airlines deal was found by Cheapflights users on 1/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 5/157:05 pm
SDF
-
DSM
1 stop5h 24m
American Airlines
Sat 5/166:00 am
DSM
-
SDF
1 stop3h 47m
American Airlines
Deal found 1/20$348
This American Airlines deal was found by Cheapflights users on 1/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 4/107:05 pm
SDF
-
DSM
1 stop5h 24m
American Airlines
Sun 4/125:00 pm
DSM
-
SDF
1 stop5h 27m
American Airlines
Deal found 1/21$377
This Southwest deal was found by Cheapflights users on 1/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 2/146:40 am
SDF
-
DSM
2 stops5h 15m
Southwest
Sun 2/155:20 am
DSM
-
SDF
2 stops10h 50m
Southwest
Deal found 1/20$403
This Southwest deal was found by Cheapflights users on 1/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 3/111:30 pm
SDF
-
DSM
1 stop8h 20m
Southwest
Sun 3/154:40 pm
DSM
-
SDF
1 stop3h 30m
Southwest
Deal found 1/21$404

Find flight deals from Louisville to Des Moines

Discover tips and strategies to find the most affordable flight options for your journey from Louisville (SDF) to Des Moines (DSM). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated January 21, 2026.

Most accurate provider

Mytrip
3 stars

Most trusted provider

Mytrip
3 stars

Round-trip from

$289
(Delta)

One-way from

$126
(Delta)
Provider with most accurate pricing for Louisville Intl-Des Moines flight deals.
Search Deals
Provider most trusted by Cheapflights users for Louisville Intl-Des Moines flights.
Search Deals
From Louisville Intl to Des Moines
Search Deals
One-way flight from Louisville Intl to Des Moines
Search Deals

Cheapflights Fare Finder

 
Customize your flight search to find flights from Louisville to Des Moines that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated January 21, 2026.
Use the filters below to find and compare flights from Louisville to Des Moines that are best for you.

Fly from

Louisville

Fly to

Des Moines

Route

Depart

Return

Price

LouisvilleDes Moines

SDF - DSM

SDFDSM

Louisville Intl

Thu 3/26

5:55 pm-8:45 pm

1 stop3h 50m

Des Moines

Mon 3/30

5:20 pm-10:43 pm

1 stop4h 23m

$289

LouisvilleDes Moines

SDF - DSM

SDFDSM

Louisville Intl

Tue 3/17

9:00 am-2:22 pm

1 stop6h 22m

Des Moines

Sun 3/22

2:04 pm-10:13 pm

1 stop7h 09m

$299

LouisvilleDes Moines

SDF - DSM

SDFDSM

Louisville Intl

Sat 2/14

5:00 am-1:05 pm

2 stops9h 05m

Des Moines

Sun 2/15

6:32 am-11:30 am

1 stop3h 58m

$304

LouisvilleDes Moines

SDF - DSM

SDFDSM

Louisville Intl

Sat 2/14

9:00 am-2:27 pm

1 stop6h 27m

Des Moines

Wed 2/18

3:24 pm-8:09 pm

1 stop3h 45m

$311

LouisvilleDes Moines

SDF - DSM

SDFDSM

Louisville Intl

Tue 3/17

6:35 am-10:05 pm

2 stops16h 30m

Des Moines

Sun 3/22

4:40 pm-9:10 pm

1 stop3h 30m

$336

LouisvilleDes Moines

SDF - DSM

SDFDSM

Louisville Intl

Fri 5/15

7:05 pm-11:29 pm

1 stop5h 24m

Des Moines

Sat 5/16

6:00 am-10:47 am

1 stop3h 47m

$348

LouisvilleDes Moines

SDF - DSM

SDFDSM

Louisville Intl

Wed 3/11

1:30 pm-8:50 pm

1 stop8h 20m

Des Moines

Sun 3/15

4:40 pm-9:10 pm

1 stop3h 30m

$404

LouisvilleDes Moines

SDF - DSM

SDFDSM

Louisville Intl

Sat 2/14

10:46 am-4:57 pm

1 stop7h 11m

$126

LouisvilleDes Moines

SDF - DSM

SDFDSM

Louisville Intl

Sat 2/14

5:00 am-1:05 pm

2 stops9h 05m

$131

LouisvilleDes Moines

SDF - DSM

SDFDSM

Louisville Intl

Mon 1/26

10:57 am-10:17 pm

1 stop12h 20m

$254

Flights are sorted by cheapest round-trip flights first.

Deals found on 1/20

Showing 1-10 of 11 results
1
2

Compare providers for flights from Louisville to Des Moines

Provider information is updated monthly. Please note that these providers often have deals for this flight, but the availability may vary on a day-by-day basis on Cheapflights.
Use the table below to compare price accuracy, trust ratings, and cancellation policies for each provider offering flight deals from Louisville to Des Moines in January.
ProviderPrice AccuracyTrust Score*
FlightHubPrice Accuracy3 starsTrust Score*1 star
ExpediaPrice Accuracy2 starsTrust Score*3 stars
MytripPrice Accuracy3 starsTrust Score*3 stars

*The Trust Score is based on feedback from users after their booking experience. It measures overall satisfaction, helping us identify issues like hidden fees, problems during the ticketing process, and the quality of customer service. This score is our best indicator of the provider's quality and reliability.

  • Most accurate provider: When it comes to deals on Louisville-Des Moines flights, users find the pricing of Mytrip to be most consistent on Cheapflights vs. Mytrip Users can find the same prices on Louisville-Des Moines flight deals on Cheapflights vs. Mytrip >95% of the time. Price accuracy is based on data collected from Louisville-Des Moines flight searches over the past month and is updated monthly.
  • Most trusted provider: When it comes to deals on Louisville-Des Moines flights, Cheapflights users trust Mytrip the most. Mytrip has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for Louisville-Des Moines flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.

Best time to book a flight from Louisville to Des Moines

Have a flexible travel schedule? Discover the best time to fly to Des Moines from Louisville with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Louisville to Des Moines

What is the cheapest month to book a flight from Louisville to Des Moines?

Currently, March is the cheapest month in which you can book a flight from Louisville to Des Moines (average of $155). Flying from Louisville to Des Moines in November is currently the most expensive (average of $426). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

Reviews of airlines servicing Des Moines

Get insights into the airlines that provide service to Des Moines. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Des Moines. Reviews last updated January 21, 2026.
Read through reviews of airlines operating flights from Louisville to Des Moines, such as Delta, United Airlines, and American Airlines. Reviews also offer insight into each airline's entertainment options, comfort, food, crew/service, and boarding process.
Delta
7.9
Good
8,089 reviews

Boarding

8.1

Overall

7.9

Crew

8.5

Entertainment

7.8

Food

7.2

Comfort

7.9

Reviews

1 / 20
6.0
Good

Jim,Nov 2025

AVL - ATL

The exit row seats without a seat in front are great for leg room but don’t have a fold out entertainment console so you’re forced to use the screen several feet in front of you (there is, at least, a remote). Best to bring a tablet loaded with entertainment or a book.
Delta
7.9
Good
8,089 reviews
Delta
7.9
Good
8,089 reviews

Boarding

8.1

Overall

7.9

Crew

8.5

Entertainment

7.8

Food

7.2

Comfort

7.9

Reviews

1 / 20
6.0
Good

Jim,Nov 2025

AVL - ATL

The exit row seats without a seat in front are great for leg room but don’t have a fold out entertainment console so you’re forced to use the screen several feet in front of you (there is, at least, a remote). Best to bring a tablet loaded with entertainment or a book.
United Airlines
7.4
Good
9,191 reviews
Delta
7.9
Good
8,089 reviews

Boarding

8.1

Overall

7.9

Crew

8.5

Entertainment

7.8

Food

7.2

Comfort

7.9

Reviews

1 / 20
6.0
Good

Jim,Nov 2025

AVL - ATL

The exit row seats without a seat in front are great for leg room but don’t have a fold out entertainment console so you’re forced to use the screen several feet in front of you (there is, at least, a remote). Best to bring a tablet loaded with entertainment or a book.
American Airlines
7.2
Good
11,174 reviews
Delta
7.9
Good
8,089 reviews

Boarding

8.1

Overall

7.9

Crew

8.5

Entertainment

7.8

Food

7.2

Comfort

7.9

Reviews

1 / 20
6.0
Good

Jim,Nov 2025

AVL - ATL

The exit row seats without a seat in front are great for leg room but don’t have a fold out entertainment console so you’re forced to use the screen several feet in front of you (there is, at least, a remote). Best to bring a tablet loaded with entertainment or a book.

Related info for your journey

Find useful and relevant information for your journey from Louisville to Des Moines. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • How long is the flight from Louisville to Des Moines?

    For as low as $289, Delta can have you in Des Moines from Louisville in 3h 50m. Airlines will cover a distance of 480 mi. Both multi-stop and nonstop flights can be found to your destination and back.

  • What are the cheapest airlines flying from Louisville to Des Moines round-trip?

    Flying on Delta is currently your cheapest option to Des Moines, with prices starting at $105. Additional round-trip tickets that might be worth considering are offered by American Airlines and United Airlines, with the lowest prices starting at $196 and $223, respectively.

  • Can I find deals for flights from Louisville to Des Moines that include hotel bookings?

    Yes. In addition to deals on Louisville to Des Moines flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Louisville to Des Moines?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Louisville to Des Moines.

  • Can I find deals for business class flights from Louisville to Des Moines?

    Yes. Cheapflights offers flight deals from Louisville to Des Moines by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Louisville to Des Moines?

    Currently, March is the cheapest month in which you can book a flight from Louisville to Des Moines (average of $155). Flying from Louisville to Des Moines in November is currently the most expensive (average of $426). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Traveling to a place near Des Moines?

Book flights to Des Moines if you plan to visit one of these locations
Altoona
Johnston
Boone
Ames
Clive
West Des Moines
Ankeny

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Top 3 airlines flying from Louisville to Des Moines

Discover the top 3 airlines that operate flights from Louisville to Des Moines. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated January 21, 2026.
AirlineCheapestAverageFlexibilityOn-time
DeltaCheapest$105Average$326FlexibilityNo cancel feeOn-timeN/A
American AirlinesCheapest$196Average$305FlexibilityNo cancel feeOn-time71%
United AirlinesCheapest$223Average$386FlexibilityNo cancel feeOn-time69%

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