$136+ Cheap flights from Louisville to Des Moines (SDF - DSM)
This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 10/29. Fares are subject to change and may not be available on all flights or dates of travel.
SDF — DSM
Sep 27 — Oct 41
Round-trip
1 adult, Economy
We work with more than 300 partners to bring you better travel deals
Find cheap flights from Louisville to Des Moines with Cheapflights
1. Tell us where you want to go
Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”2. Select your favorite providers
We find the providers serving your travel needs. Choose up to four travel providers to compare side-by-side for flights, hotels, or car rentals.3. Compare prices and book
Review each provider’s pricing and select the best option for you! Book through your favorite provider’s website for a seamless experience.Cheap flight deals from Louisville to Des Moines
Cheapest
Best
Last-minute
One-way
Cheapest flights from Louisville to Des MoinesExplore the most affordable flight options available from Louisville to Des Moines. Find the lowest fares from popular airlines and budget airlines, with prices last updated on August 28, 2026.
Explore the most affordable flight options available from Louisville to Des Moines. Find the lowest fares from popular airlines and budget airlines, with prices last updated on August 28, 2026.
This United Airlines deal was found by Cheapflights users on 8/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/239:00 am -
1 stop6h 20m
Wed 9/306:55 pm -
1 stop4h 04m
Deal found 8/24![United Airlines logo]()
$279
This Southwest deal was found by Cheapflights users on 8/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/235:30 am -
2 stops7h 20m
Wed 9/306:10 am -
1 stop4h 10m
Deal found 8/24![Southwest logo]()
$309
This Delta deal was found by Cheapflights users on 8/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/301:59 pm -
1 stop5h 10m
Mon 11/25:39 am -
1 stop6h 15m
Deal found 8/25![Delta logo]()
$328
This United Airlines deal was found by Cheapflights users on 8/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 11/103:24 pm -
1 stop6h 12m
Wed 11/119:55 am -
1 stop6h 07m
Deal found 8/27![United Airlines logo]()
$349
This Delta deal was found by Cheapflights users on 8/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 9/276:00 am -
1 stop5h 46m
Tue 9/295:59 pm -
1 stop4h 44m
Deal found 8/27![Delta logo]()
$359
This Delta deal was found by Cheapflights users on 8/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 9/138:09 am -
1 stop6h 40m
Tue 9/155:59 pm -
1 stop4h 44m
Deal found 8/24![Delta logo]()
$374
This United Airlines deal was found by Cheapflights users on 8/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 9/137:10 am -
1 stop4h 21m
Tue 9/156:24 am -
1 stop5h 44m
Deal found 8/23![United Airlines logo]()
$408
This Delta deal was found by Cheapflights users on 8/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 9/1010:32 am -
1 stop7h 17m
Sun 9/136:54 pm -
1 stop4h 05m
Deal found 8/27![Delta logo]()
$430
This Southwest deal was found by Cheapflights users on 8/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 9/88:45 am -
1 stop4h 05m
Sat 9/1212:10 pm -
2 stops8h 15m
Deal found 8/23![Southwest logo]()
$435
This Kiwi.com deal was found by Cheapflights users on 8/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 9/105:24 pm -
1 stop16h 45m
Sun 9/139:39 am -
2 stops23h 06m
Deal found 8/25![Multiple Airlines logo]()
$462
Best flights from Louisville to Des MoinesDiscover carefully curated flight deals from Louisville to Des Moines that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated August 28, 2026.
Discover carefully curated flight deals from Louisville to Des Moines that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated August 28, 2026.
This United Airlines deal was found by Cheapflights users on 8/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/239:00 am -
1 stop6h 20m
Wed 9/306:55 pm -
1 stop4h 04m
Deal found 8/24![United Airlines logo]()
$279
This Southwest deal was found by Cheapflights users on 8/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/235:30 am -
2 stops7h 20m
Wed 9/306:10 am -
1 stop4h 10m
Deal found 8/24![Southwest logo]()
$309
This Delta deal was found by Cheapflights users on 8/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 9/276:00 am -
1 stop5h 46m
Tue 9/295:59 pm -
1 stop4h 44m
Deal found 8/27![Delta logo]()
$359
This United Airlines deal was found by Cheapflights users on 8/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 11/103:24 pm -
1 stop6h 12m
Wed 11/119:55 am -
1 stop6h 07m
Deal found 8/27![United Airlines logo]()
$349
This Delta deal was found by Cheapflights users on 8/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 9/136:00 am -
1 stop5h 46m
Tue 9/155:59 pm -
1 stop4h 44m
Deal found 8/25![Delta logo]()
$374
This United Airlines deal was found by Cheapflights users on 8/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 9/137:10 am -
1 stop4h 21m
Tue 9/156:24 am -
1 stop5h 44m
Deal found 8/23![United Airlines logo]()
$408
This Delta deal was found by Cheapflights users on 8/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 9/1010:32 am -
1 stop7h 17m
Sun 9/136:54 pm -
1 stop4h 05m
Deal found 8/27![Delta logo]()
$430
This Delta deal was found by Cheapflights users on 8/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 9/86:30 am -
1 stop4h 47m
Sat 9/1211:31 am -
1 stop6h 59m
Deal found 8/23![Delta logo]()
$430
Last-minute flights from Louisville to Des MoinesDiscover last-minute flight deals from Louisville to Des Moines. Data last updated August 28, 2026 and is based on user searches.
Discover last-minute flight deals from Louisville to Des Moines. Data last updated August 28, 2026 and is based on user searches.
This Southwest deal was found by Cheapflights users on 8/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 9/88:45 am -
1 stop4h 05m
Sat 9/1212:10 pm -
2 stops8h 15m
Deal found 8/23![Southwest logo]()
$435
This Southwest deal was found by Cheapflights users on 8/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected ” under the list of providers to see comparable flight deals.
Wed 9/95:30 am -
2 stops7h 20m
Sun 9/135:40 am -
2 stops7h 30m
Deal found 8/25![Southwest logo]()
$483
This Delta deal was found by Cheapflights users on 8/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 9/1010:32 am -
1 stop7h 17m
Sun 9/136:54 pm -
1 stop4h 05m
Deal found 8/27![Delta logo]()
$430
This Kiwi.com deal was found by Cheapflights users on 8/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 9/105:24 pm -
1 stop16h 45m
Sun 9/139:39 am -
2 stops23h 06m
Deal found 8/25![Multiple Airlines logo]()
$462
This Delta deal was found by Cheapflights users on 8/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 9/138:09 am -
1 stop6h 40m
Tue 9/155:59 pm -
1 stop4h 44m
Deal found 8/24![Delta logo]()
$374
This United Airlines deal was found by Cheapflights users on 8/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 9/137:10 am -
1 stop4h 21m
Tue 9/156:24 am -
1 stop5h 44m
Deal found 8/23![United Airlines logo]()
$408
This United Airlines deal was found by Cheapflights users on 8/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/239:00 am -
1 stop6h 20m
Wed 9/306:55 pm -
1 stop4h 04m
Deal found 8/24![United Airlines logo]()
$279
This Southwest deal was found by Cheapflights users on 8/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/235:30 am -
2 stops7h 20m
Wed 9/306:10 am -
1 stop4h 10m
Deal found 8/24![Southwest logo]()
$309
This Delta deal was found by Cheapflights users on 8/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 9/276:00 am -
1 stop5h 46m
Tue 9/295:59 pm -
1 stop4h 44m
Deal found 8/27![Delta logo]()
$359
One-way flights from Louisville to Des MoinesSearch for one-way flight options from Louisville to Des Moines. Find affordable one-way fares based on user searches. Data last updated August 28, 2026.
Search for one-way flight options from Louisville to Des Moines. Find affordable one-way fares based on user searches. Data last updated August 28, 2026.
This Kiwi.com deal was found by Cheapflights users on 8/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/299:43 pm -
1 stop11h 42m
Deal found 8/27![Allegiant Air logo]()
$136
This Delta deal was found by Cheapflights users on 8/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 9/142:47 pm -
1 stop6h 59m
Deal found 8/25![Delta logo]()
$140
This Southwest deal was found by Cheapflights users on 8/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/295:35 am -
2 stops6h 35m
Deal found 8/27![Southwest logo]()
$145
This Delta deal was found by Cheapflights users on 8/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/96:00 am -
1 stop5h 46m
Deal found 8/23![Delta logo]()
$196
This Kiwi.com deal was found by Cheapflights users on 8/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 9/147:59 pm -
2 stops40h 55m
Deal found 8/26![Multiple Airlines logo]()
$198
This Southwest deal was found by Cheapflights users on 8/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/910:50 am -
2 stops11h 15m
Deal found 8/23![Southwest logo]()
$201
This Southwest deal was found by Cheapflights users on 8/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 9/143:20 pm -
2 stops7h 55m
Deal found 8/25![Southwest logo]()
$204
This Kiwi.com deal was found by Cheapflights users on 8/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/910:56 am -
3 stops34h 01m
Deal found 8/23![Multiple Airlines logo]()
$225
This United Airlines deal was found by Cheapflights users on 8/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/297:00 am -
1 stop15h 55m
Deal found 8/27![United Airlines logo]()
$297
Find flight deals from Louisville to Des Moines
Discover tips and strategies to find the most affordable flight options for your journey from Louisville (SDF) to Des Moines (DSM). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated August 28, 2026.
Most accurate provider | FlightHub 3 stars |
|---|---|
Most trusted provider | FlightHub 3 stars |
Round-trip from | $279 (United Airlines) |
One-way from | $136 (Kiwi.com) |
Cheapflights Fare Finder
Customize your flight search to find flights from Louisville to Des Moines that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 7,457,451 searches. Data last updated August 28, 2026.
Use the filters below to find and compare flights from Louisville to Des Moines that are best for you.
Fly from
Fly to
Route
Depart
Return
Cheapest round-trip
LouisvilleDes Moines
SDF Louisville Intl - DSM Des Moines
SDFDSM
Louisville Intl
Wed 9/23
9:00 am-2:20 pm
1 stop6h 20m
Des Moines
Wed 9/30
6:55 pm-11:59 pm
1 stop4h 04m
$279
LouisvilleDes Moines
SDF Louisville Intl - DSM Des Moines
SDFDSM
Louisville Intl
Wed 9/23
5:30 am-11:50 am
2 stops7h 20m
Des Moines
Wed 9/30
6:10 am-11:20 am
1 stop4h 10m
$309
LouisvilleDes Moines
SDF Louisville Intl - DSM Des Moines
SDFDSM
Louisville Intl
Tue 11/10
3:24 pm-8:36 pm
1 stop6h 12m
Des Moines
Wed 11/11
9:55 am-5:02 pm
1 stop6h 07m
$349
LouisvilleDes Moines
SDF Louisville Intl - DSM Des Moines
SDFDSM
Louisville Intl
Sun 9/27
6:00 am-10:46 am
1 stop5h 46m
Des Moines
Tue 9/29
5:59 pm-11:43 pm
1 stop4h 44m
$359
LouisvilleDes Moines
SDF Louisville Intl - DSM Des Moines
SDFDSM
Louisville Intl
Sun 9/13
6:00 am-10:46 am
1 stop5h 46m
Des Moines
Tue 9/15
5:59 pm-11:43 pm
1 stop4h 44m
$374
Quickest round-trip
LouisvilleDes Moines
SDF Louisville Intl - DSM Des Moines
SDFDSM
Louisville Intl
Sun 9/13
7:10 am-10:31 am
1 stop4h 21m
Des Moines
Tue 9/15
6:24 am-1:08 pm
1 stop5h 44m
$408
LouisvilleDes Moines
SDF Louisville Intl - DSM Des Moines
SDFDSM
Louisville Intl
Thu 9/10
10:32 am-4:49 pm
1 stop7h 17m
Des Moines
Sun 9/13
6:54 pm-11:59 pm
1 stop4h 05m
$430
LouisvilleDes Moines
SDF Louisville Intl - DSM Des Moines
SDFDSM
Louisville Intl
Tue 9/8
6:30 am-10:17 am
1 stop4h 47m
Des Moines
Sat 9/12
11:31 am-7:30 pm
1 stop6h 59m
$430
Cheapest one-way
LouisvilleDes Moines
SDF Louisville Intl - DSM Des Moines
SDFDSM
Louisville Intl
Thu 10/29
9:43 pm-8:25 am
1 stop11h 42m
$136
LouisvilleDes Moines
SDF Louisville Intl - DSM Des Moines
SDFDSM
Louisville Intl
Mon 9/14
2:47 pm-8:46 pm
1 stop6h 59m
$140
Showing 1-10 of 17 resultsSorted by cheapest first
Compare providers for flights from Louisville to Des Moines
Provider information is updated monthly. Please note that these providers often have deals for this flight, but the availability may vary on a day-by-day basis on Cheapflights.
Use the table below to compare price accuracy, trust ratings, and cancellation policies for each provider offering flight deals from Louisville to Des Moines in August.
| Provider | Price Accuracy | Trust Score* |
|---|---|---|
| Price Accuracy1 star | Trust Score*3 stars | |
| Price Accuracy3 stars | Trust Score*3 stars | |
| Price Accuracy3 stars | Trust Score*3 stars |
- Most accurate provider: When it comes to deals on Louisville-Des Moines flights, users find the pricing of FlightHub to be most consistent on Cheapflights vs. FlightHub Users can find the same prices on Louisville-Des Moines flight deals on Cheapflights vs. FlightHub >95% of the time. Price accuracy is based on data collected from Louisville-Des Moines flight searches over the past month and is updated monthly.
- Most trusted provider: When it comes to deals on Louisville-Des Moines flights, Cheapflights users trust FlightHub the most. FlightHub has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for Louisville-Des Moines flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.
Best time to book a flight from Louisville to Des Moines
Have a flexible travel schedule? Discover the best time to fly to Des Moines from Louisville with our price prediction graph.
SDF-DSM
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.
Reviews of airlines servicing Des Moines
Get insights into the airlines that provide service to Des Moines. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Des Moines. Reviews last updated August 28, 2026.
Read through reviews of airlines operating flights from Louisville to Des Moines, such as Delta and United Airlines. Reviews also offer insight into each airline's entertainment options, comfort, food, crew/service, and boarding process.
Crew
8.5
Boarding
8.1
Entertainment
7.8
Comfort
7.8
Overall
7.8
Food
7.2
Reviews
1 / 20
8.0
ExcellentJorge,Aug 2026
TPA - ATL
Crew
8.5
Boarding
8.1
Entertainment
7.8
Comfort
7.8
Overall
7.8
Food
7.2
Reviews
1 / 20
8.0
ExcellentJorge,Aug 2026
TPA - ATL
Crew
8.5
Boarding
8.1
Entertainment
7.8
Comfort
7.8
Overall
7.8
Food
7.2
Reviews
1 / 20
8.0
ExcellentJorge,Aug 2026
TPA - ATL
Related info for your journey
Find useful and relevant information for your journey from Louisville to Des Moines. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.
Traveling to a place near Des Moines?
Book flights to Des Moines if you plan to visit one of these locationsAltoona
Clive
Ames
Johnston
Boone
Norwalk
West Des Moines
Ankeny
Browse thousands of different options on Cheapflights for your next trip
Toggle through the tabs below to find thousands of options on Cheapflights for your next trip.
Alternative routes
Complete your trip
Des Moines flight routes
Flights by cabin class
Other flight options
Other flights from Louisville
Popular flights
Alternative routes for Louisville to Des Moines
See prices for flight routes from nearby airports that may be better suited for you.
Complete your trip
Complete your trip to Des Moines by adding a car rental and/or hotel reservation to your travel itinerary.
Other flights to Des Moines
Explore flights to Des Moines departing from other origins. Flights are based on user searches made on Cheapflights and were last updated on August 28, 2026.
Search flights from Louisville to Des Moines by cabin class
Find flights from Louisville to Des Moines, based on your preferred cabin class, be it economy, premium economy, business, or first class.
Louisville and Des Moines flights
Browse other Louisville and Des Moines flight options. Last updated on August 28, 2026.
Other flights from Louisville
Browse through other flights departing from Louisville. Flights are based on user searches made on Cheapflights and were last updated on August 28, 2026.
Popular flight searches
Check out other popular destinations found by fellow travelers in 2026
Top 2 airlines flying from Louisville to Des Moines
Discover the top 2 airlines that operate flights from Louisville to Des Moines. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 7,457,451 searches. Data last updated August 28, 2026.
| Airline | Cheapest | Average | Flexibility | On-time |
|---|---|---|---|---|
| Cheapest$233 | Average$346 | FlexibilityNo cancel fee | On-timeN/A | |
| Cheapest$248 | Average$456 | FlexibilityNo cancel fee | On-time69% |