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Des Moines

$78+ Cheap flights from Indiana to Des Moines (DSM)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 4/9. Fares are subject to change and may not be available on all flights or dates of travel.
IND — DSM
Mar 30 — Apr 61
Mon 3/30
Mon 4/6
1 adult, Economy
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Cheap flight deals from Indiana to Des Moines

Cheapest flights from Indiana to Des Moines
Explore the most affordable flight options available from Indiana to Des Moines. Find the lowest fares from popular airlines and budget airlines, with prices last updated on February 28, 2026.

This Southwest deal was found by Cheapflights users on 2/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 4/1810:05 am
MDW
-
DSM
Nonstop1h 25m
Southwest
Sun 4/194:20 pm
DSM
-
MDW
Nonstop1h 20m
Southwest
Deal found 2/27$199
This American Airlines deal was found by Cheapflights users on 2/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 4/89:00 am
ORD
-
DSM
Nonstop1h 26m
American Airlines
Sat 4/1111:09 am
DSM
-
ORD
Nonstop1h 34m
American Airlines
Deal found 2/27$201
This Delta deal was found by Cheapflights users on 2/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 5/61:36 pm
ORD
-
DSM
1 stop7h 03m
Delta
Sun 5/106:15 am
DSM
-
ORD
1 stop4h 12m
Delta
Deal found 2/24$206
This Delta deal was found by Cheapflights users on 2/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 3/1412:15 pm
ORD
-
DSM
1 stop3h 27m
Delta
Sun 3/2210:28 am
DSM
-
ORD
1 stop6h 15m
Delta
Deal found 2/23$207
This American Airlines deal was found by Cheapflights users on 2/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 3/175:03 pm
ORD
-
DSM
Nonstop1h 25m
American Airlines
Sat 3/216:00 am
DSM
-
ORD
Nonstop1h 45m
American Airlines
Deal found 2/27$209
This Southwest deal was found by Cheapflights users on 2/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 4/1610:20 am
MDW
-
DSM
Nonstop1h 25m
Southwest
Sun 4/194:20 pm
DSM
-
MDW
Nonstop1h 20m
Southwest
Deal found 2/27$209
This United Airlines deal was found by Cheapflights users on 2/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 4/1610:52 am
ORD
-
DSM
Nonstop1h 37m
United Airlines
Sat 4/183:21 pm
DSM
-
ORD
Nonstop1h 34m
United Airlines
Deal found 2/24$212
This Kiwi.com deal was found by Cheapflights users on 2/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 4/1610:55 am
ORD
-
DSM
1 stop26h 14m
Frontier
Mon 4/202:04 pm
DSM
-
ORD
2 stops19h 36m
Frontier
Deal found 2/25$213
This Delta deal was found by Cheapflights users on 2/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 3/178:55 am
ORD
-
DSM
1 stop6h 47m
Delta
Mon 3/234:25 pm
DSM
-
ORD
1 stop3h 24m
Delta
Deal found 2/26$214
This Delta deal was found by Cheapflights users on 2/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 4/31:10 pm
MDW
-
DSM
1 stop3h 44m
Delta
Mon 4/66:15 am
DSM
-
MDW
1 stop6h 14m
Delta
Deal found 2/25$214
This United Airlines deal was found by Cheapflights users on 2/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 4/98:00 pm
ORD
-
DSM
Nonstop1h 32m
United Airlines
Fri 4/178:04 am
DSM
-
ORD
Nonstop1h 32m
United Airlines
Deal found 2/26$215
This American Airlines deal was found by Cheapflights users on 2/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 4/110:26 pm
ORD
-
DSM
Nonstop1h 22m
American Airlines
Thu 4/96:00 am
DSM
-
ORD
Nonstop1h 41m
American Airlines
Deal found 2/26$216

Find flight deals from Indiana to Des Moines

Keep the following information in mind while searching for Indiana to Des Moines flight deals. Data was last updated February 28, 2026.

Most accurate provider

FlightHub
3 stars

Most trusted provider

FlightHub
3 stars

Round-trip from

$201
(American Airlines)

One-way from

$78
(United Airlines)

Popular in

April

Cheapest in

December

Average price

$490
Provider with most accurate pricing for Indianapolis-Des Moines flight deals.
Search Deals
Provider most trusted by Cheapflights users for Indianapolis-Des Moines flights.
Search Deals
From Indiana to Des Moines
Search Deals
One-way flight from Indiana to Des Moines
Search Deals
Highest demand for flights based on searches. 2% potential increase in price ($8 potential increase over avg. RT price).
Search Deals
Cheapest flight prices on average. 4% potential price decrease ($15 potential savings vs. average RT price).
Search Deals
Average for round-trip flights in February 2026
Search Deals

Cheapflights Fare Finder

 
Customize your flight search to find flights from Indiana to Des Moines that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated February 28, 2026.
Use the filters below to find and compare flights from Indiana to Des Moines that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

ChicagoDes Moines

MDW - DSM

MDWDSM

Chicago Midway

Sat 4/18

1:55 pm-8:55 pm

1 stop7h 00m

Des Moines

Sun 4/19

5:20 am-6:40 am

Nonstop1h 20m

$202

ChicagoDes Moines

MDW - DSM

MDWDSM

Chicago Midway

Wed 5/6

6:30 am-2:05 pm

1 stop7h 35m

Des Moines

Mon 5/11

4:20 pm-5:40 pm

Nonstop1h 20m

$202

ChicagoDes Moines

ORD - DSM

ORDDSM

Chicago O'Hare Intl

Wed 5/6

6:25 am-10:16 am

1 stop3h 51m

Des Moines

Sun 5/10

1:04 pm-7:20 pm

1 stop6h 16m

$206

ChicagoDes Moines

ORD - DSM

ORDDSM

Chicago O'Hare Intl

Wed 3/25

6:15 am-10:09 am

1 stop3h 54m

Des Moines

Sat 3/28

4:25 pm-7:49 pm

1 stop3h 24m

$207

ChicagoDes Moines

ORD - DSM

ORDDSM

Chicago O'Hare Intl

Tue 3/17

8:55 am-3:42 pm

1 stop6h 47m

Des Moines

Tue 3/24

4:25 pm-7:49 pm

1 stop3h 24m

$207

ChicagoDes Moines

ORD - DSM

ORDDSM

Chicago O'Hare Intl

Wed 5/6

9:01 am-10:37 am

Nonstop1h 36m

Des Moines

Sun 5/10

3:20 pm-4:52 pm

Nonstop1h 32m

$209

ChicagoDes Moines

ORD - DSM

ORDDSM

Chicago O'Hare Intl

Thu 4/16

10:52 am-12:29 pm

Nonstop1h 37m

Des Moines

Sat 4/18

3:21 pm-4:55 pm

Nonstop1h 34m

$212

ChicagoDes Moines

MDW - DSM

MDWDSM

Chicago Midway

Wed 4/8

1:10 pm-4:54 pm

1 stop3h 44m

Des Moines

Sat 4/11

12:29 pm-5:54 pm

1 stop5h 25m

$221

ChicagoDes Moines

MDW - DSM

MDWDSM

Chicago Midway

Thu 4/16

10:20 am-11:45 am

Nonstop1h 25m

Des Moines

Mon 4/20

6:50 am-2:20 pm

1 stop7h 30m

$226

ChicagoDes Moines

MDW - DSM

MDWDSM

Chicago Midway

Thu 4/9

10:20 am-11:45 am

Nonstop1h 25m

Des Moines

Mon 4/13

4:20 pm-5:40 pm

Nonstop1h 20m

$228

Flights are sorted by cheapest round-trip flights first.

Deals found on 2/24

Showing 1-10 of 60 resultsSorted by cheapest first
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Best time to book a flight from Indiana to Des Moines

Have a flexible travel schedule? Discover the best time to fly to Des Moines from Indiana with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Indiana to Des Moines

What is the cheapest month to book a flight from Indiana to Des Moines?

Currently, March is the cheapest month in which you can book a flight from Indiana to Des Moines (average of $193). Flying from Indiana to Des Moines in January is currently the most expensive (average of $307). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

Related info for your journey

Find useful and relevant information for your journey from Indiana to Des Moines. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airport do you fly into for flights to Des Moines from Indiana?

    For a flight from Indiana to Des Moines, you will be flying into Des Moines. Des Moines (DSM) is just 3.6 mi from the center of the city.

  • How long is the flight from Indiana to Des Moines?

    Airlines like Southwest, Delta, and United Airlines fly from Indiana to Des Moines in about 1h 36m. The time it takes to get you to your destination can typically vary by up to 5h 24m. The distance from Indiana to Des Moines is about 298 mi. This flight may include one or multiple stops.

  • What are the cheapest airlines to fly from Indiana to Des Moines one-way?

    The cheapest airlines for a one-way flight from Indiana to Des Moines are American Airlines ($114), United Airlines ($128), and Delta ($209).

  • What are the most popular routes from Indiana to Des Moines?

    Most travelers choose Chicago O'Hare Intl - Des Moines, Indianapolis - Des Moines or Cincinnati Cinci./N. Kentucky - Des Moines when deciding on the best route from Indiana to Des Moines.

  • Can I find deals for flights from Indiana to Des Moines that include hotel bookings?

    Yes. In addition to deals on Indiana to Des Moines flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Indiana to Des Moines?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Indiana to Des Moines.

  • Can I find deals for business class flights from Indiana to Des Moines?

    Yes. Cheapflights offers flight deals from Indiana to Des Moines by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Indiana to Des Moines?

    Currently, March is the cheapest month in which you can book a flight from Indiana to Des Moines (average of $193). Flying from Indiana to Des Moines in January is currently the most expensive (average of $307). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Traveling to a place near Des Moines?

Book flights to Des Moines if you plan to visit one of these locations
Altoona
Johnston
Ankeny
Boone
Ames
Clive
West Des Moines

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Alternative routes for Indiana to Des Moines

See prices for flight routes from nearby airports that may be better suited for you.
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Top 3 airlines flying from Indiana to Des Moines

Discover the top 3 airlines that operate flights from Indiana to Des Moines. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated February 28, 2026.
AirlineCheapestAverageFlexibilityOn-time
DeltaCheapest$183Average$321FlexibilityNo cancel feeOn-timeN/A
American AirlinesCheapest$200Average$386FlexibilityNo cancel feeOn-time71%
United AirlinesCheapest$228Average$350FlexibilityNo cancel feeOn-time69%

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