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$51+ Cheap flights from Knoxville (TYS) to Chicago (CHI)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 11/14. Fares are subject to change and may not be available on all flights or dates of travel.
TYS — CHI
Oct 11 — Oct 181
Sat 10/11
Sat 10/18
1 adult, Economy
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Cheapflights Tip: The best prices from Knoxville McGhee Tyson to Chicago are usually found in September or February, booked 81 days in advance, depart on a Friday or Thursday and return on a Wednesday

Cheap flight deals from Knoxville to Chicago

Discover tips and strategies to find the most affordable flight options for your journey from Knoxville (TYS) to Chicago (CHI). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated September 11, 2025.

Round-trip from

$93
(Cheapflightsfares)

One-way from

$51
(Cheapflightsfares)

Popular in

July

Cheapest in

September

Average price

$201

Good round-trip deal

$82 or less

Good one-way deal

$68 or less
From Knoxville McGhee Tyson to Chicago (CHI)
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One-way flight from Knoxville McGhee Tyson to Chicago (CHI)
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Highest demand for flights based on searches. 9% potential increase in price ($26 potential increase over avg. RT price).
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Cheapest flight prices on average. 3% potential price decrease ($8 potential savings vs. average RT price).
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Average for round-trip flights in September 2025
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Price to beat on a round-trip flight from Knoxville McGhee Tyson to Chicago (CHI).
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Price to beat on a one-way flight from Knoxville McGhee Tyson to Chicago (CHI).
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Find flight deals from Knoxville to Chicago

Cheapest flights from Knoxville to Chicago
Explore the most affordable flight options available from Knoxville to Chicago. Find the lowest fares from popular airlines and budget airlines, with prices last updated on September 11, 2025.

This Cheapflightsfares deal was found by Cheapflights users on 9/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Cheapflightsfares is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/1710:44 amTYS - MDW
Nonstop1h 32mAllegiant Air
Mon 10/2012:08 pmMDW - TYS
Nonstop1h 24mAllegiant Air
Deal found 9/11$96
This Kiwi.com deal was found by Cheapflights users on 9/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 9/266:24 pmTYS - MDW
Nonstop1h 36mAllegiant Air
Mon 9/293:16 pmMDW - TYS
Nonstop1h 31mAllegiant Air
Deal found 9/10$106
This Cheapflightsfares deal was found by Cheapflights users on 9/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Cheapflightsfares is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 11/71:32 pmTYS - MDW
Nonstop1h 35mAllegiant Air
Mon 11/104:12 pmMDW - TYS
Nonstop1h 25mAllegiant Air
Deal found 9/11$112
This Kiwi.com deal was found by Cheapflights users on 9/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/241:23 pmTYS - MDW
Nonstop1h 32mAllegiant Air
Fri 10/317:06 pmMDW - TYS
Nonstop1h 24mAllegiant Air
Deal found 9/9$117
This Kiwi.com deal was found by Cheapflights users on 9/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 10/277:02 pmTYS - MDW
Nonstop1h 32mAllegiant Air
Fri 10/317:06 pmMDW - TYS
Nonstop1h 24mAllegiant Air
Deal found 9/9$119
This Cheapflightsfares deal was found by Cheapflights users on 9/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Cheapflightsfares is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 9/126:24 pmTYS - MDW
Nonstop1h 36mAllegiant Air
Mon 9/157:50 pmMDW - TYS
Nonstop1h 31mAllegiant Air
Deal found 9/10$121
This Cheapflightsfares deal was found by Cheapflights users on 9/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Cheapflightsfares is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 11/71:32 pmTYS - MDW
Nonstop1h 35mAllegiant Air
Fri 11/143:27 pmMDW - TYS
Nonstop1h 25mAllegiant Air
Deal found 9/9$125
This Cheapflightsfares deal was found by Cheapflights users on 9/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Cheapflightsfares is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 9/126:24 pmTYS - MDW
Nonstop1h 36mAllegiant Air
Fri 9/197:50 pmMDW - TYS
Nonstop1h 31mAllegiant Air
Deal found 9/11$144
This Kiwi.com deal was found by Cheapflights users on 9/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/177:02 pmTYS - MDW
1 stop23h 11mMultiple Airlines
Mon 10/2012:08 pmMDW - TYS
Nonstop1h 24mMultiple Airlines
Deal found 9/10$154
This Cheapflightsfares deal was found by Cheapflights users on 9/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Cheapflightsfares is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/1010:44 amTYS - MDW
Nonstop1h 32mAllegiant Air
Mon 10/1312:08 pmMDW - TYS
Nonstop1h 24mAllegiant Air
Deal found 9/11$156
This Kiwi.com deal was found by Cheapflights users on 9/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/137:17 pmTYS - ORD
1 stop29h 58mFrontier
Sun 11/166:00 amORD - TYS
1 stop11h 22mFrontier
Deal found 9/11$170
This Kiwi.com deal was found by Cheapflights users on 9/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 10/2111:23 amTYS - ORD
1 stop8h 15mMultiple Airlines
Mon 10/2710:51 amORD - TYS
1 stop7h 41mMultiple Airlines
Deal found 9/9$184

Cheapflights Fare Finder

 
Customize your flight search to find flights from Knoxville to Chicago that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated September 11, 2025.
Use the filters below to find and compare flights from Knoxville to Chicago that are best for you.

Fly from

Knoxville

Fly to

Chicago

Route

Depart

Return

Price

KnoxvilleChicago

TYS - MDW

TYSMDW

Knoxville McGhee Tyson

Fri 10/24

1:23 pm-1:55 pm

Nonstop1h 32m

Chicago Midway

Fri 10/31

7:06 pm-9:30 pm

Nonstop1h 24m

$117

KnoxvilleChicago

TYS - MDW

TYSMDW

Knoxville McGhee Tyson

Fri 10/17

7:02 pm-5:13 pm

1 stop23h 11m

Chicago Midway

Mon 10/20

12:08 pm-2:32 pm

Nonstop1h 24m

$154

KnoxvilleChicago

TYS - ORD

TYSORD

Knoxville McGhee Tyson

Wed 11/5

8:26 am-9:30 am

Nonstop2h 04m

Chicago O'Hare Intl

Tue 11/11

7:20 am-10:05 am

Nonstop1h 45m

$189

KnoxvilleChicago

TYS - ORD

TYSORD

Knoxville McGhee Tyson

Sat 9/27

7:00 am-7:55 am

Nonstop1h 55m

Chicago O'Hare Intl

Sun 9/28

10:35 am-1:25 pm

Nonstop1h 50m

$199

KnoxvilleChicago

TYS - MDW

TYSMDW

Knoxville McGhee Tyson

Sat 11/15

6:12 pm-10:26 am

2 stops17h 14m

Chicago Midway

Mon 11/17

4:12 pm-6:37 pm

Nonstop1h 25m

$206

KnoxvilleChicago

TYS - MDW

TYSMDW

Knoxville McGhee Tyson

Wed 10/1

5:45 am-9:40 am

1 stop4h 55m

Chicago Midway

Sat 10/4

1:43 pm-10:35 pm

1 stop7h 52m

$209

KnoxvilleChicago

TYS - MDW

TYSMDW

Knoxville McGhee Tyson

Fri 10/24

12:47 pm-6:25 pm

1 stop6h 38m

Chicago Midway

Tue 10/28

5:04 pm-11:07 pm

1 stop5h 03m

$209

KnoxvilleChicago

TYS - MDW

TYSMDW

Knoxville McGhee Tyson

Tue 10/21

12:47 pm-6:25 pm

1 stop6h 38m

Chicago Midway

Mon 10/27

6:00 am-1:42 pm

1 stop6h 42m

$209

KnoxvilleChicago

TYS - MDW

TYSMDW

Knoxville McGhee Tyson

Thu 10/23

5:44 am-9:51 am

1 stop5h 07m

Chicago Midway

Tue 10/28

6:00 am-1:42 pm

1 stop6h 42m

$209

KnoxvilleChicago

TYS - MDW

TYSMDW

Knoxville McGhee Tyson

Fri 10/24

12:47 pm-6:25 pm

1 stop6h 38m

Chicago Midway

Sat 10/25

4:23 pm-11:07 pm

1 stop5h 44m

$209

Flights are sorted by cheapest round-trip flights first.

Deals found on 9/10

Showing 1-10 of 44 results
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Best time to book a flight from Knoxville to Chicago

Have a flexible travel schedule? Discover the best time to fly to Chicago from Knoxville with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Knoxville to Chicago

How far ahead should I book a flight from Knoxville to Chicago?

Use this chart to determine the optimal time to book a round-trip flight from Knoxville to Chicago. Price data was last updated on August 29, 2025.

The best time to book flights from Knoxville to Chicago is 81 days before your desired departure date. The cost of your flight will likely increase significantly if you book two weeks in advance of your flight.

What is the cheapest month to book a flight from Knoxville to Chicago?

Currently, August is the cheapest month in which you can book a flight from Knoxville to Chicago (average of $245). Flying from Knoxville to Chicago in March is currently the most expensive (average of $321). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from TYS to CHI?

Find hourly flight availability from Knoxville to Chicago. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated September 11, 2025.

It’s typically best to fly out from Knoxville to Chicago in the morning. Doing so could potentially save you 40% on the flight price compared to flying in the evening, which is usually more expensive.

What is the cheapest day to fly from Knoxville to Chicago?

Use this chart to determine the cheapest time to fly round-trip from Knoxville to Chicago. Price data was last updated on September 7, 2025.

Travelers seeking maximum savings on their Knoxville to Chicago flight should consider departing on Thursday evenings when fares are most often at their lowest. Sunday evenings flights should be avoided if possible as fares are typically the most expensive at this time.

Weekly flight availability from Knoxville to Chicago

Explore weekly flight availability from Knoxville to Chicago. Discover flights operating on different days of the week, giving you the flexibility to choose a travel day that best fits your plans. Compare info to find the most convenient option for your journey. Data last updated September 11, 2025.

The most flights from TYS to CHI are scheduled on a Wednesday (31 on average). You will have fewer flight options on Saturday, which is when the least amount of flights are scheduled (12 on average).

Reviews of airlines servicing Chicago

Get insights into the airlines that provide service to Chicago. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Chicago. Reviews last updated September 11, 2025.
Peruse reviews from past customers who have flown with United Airlines, American Airlines, and Allegiant Air from Knoxville to Chicago to help guide your decision. You can also see how each airline stacks up in terms of entertainment options, comfort, food, crew/service, and boarding process.
United Airlines
7.4
Good
8,937 reviews

Entertainment

7.1

Food

6.6

Boarding

7.7

Comfort

7.3

Overall

7.4

Crew

8.1

Reviews

1 / 20
2.0
Mediocre

Deb,Jan 2025

MKE - ORD

It was terrible! So much to say, but in a nutshell we used vouchers from United because our last trip with them was awful with many mishaps and errors made. Unfortunately, this trip was even worse!
United Airlines
7.4
Good
8,937 reviews
United Airlines
7.4
Good
8,937 reviews

Entertainment

7.1

Food

6.6

Boarding

7.7

Comfort

7.3

Overall

7.4

Crew

8.1

Reviews

1 / 20
2.0
Mediocre

Deb,Jan 2025

MKE - ORD

It was terrible! So much to say, but in a nutshell we used vouchers from United because our last trip with them was awful with many mishaps and errors made. Unfortunately, this trip was even worse!
American Airlines
7.2
Good
10,000 reviews
United Airlines
7.4
Good
8,937 reviews

Entertainment

7.1

Food

6.6

Boarding

7.7

Comfort

7.3

Overall

7.4

Crew

8.1

Reviews

1 / 20
2.0
Mediocre

Deb,Jan 2025

MKE - ORD

It was terrible! So much to say, but in a nutshell we used vouchers from United because our last trip with them was awful with many mishaps and errors made. Unfortunately, this trip was even worse!
Allegiant Air
7.2
Good
702 reviews
United Airlines
7.4
Good
8,937 reviews

Entertainment

7.1

Food

6.6

Boarding

7.7

Comfort

7.3

Overall

7.4

Crew

8.1

Reviews

1 / 20
2.0
Mediocre

Deb,Jan 2025

MKE - ORD

It was terrible! So much to say, but in a nutshell we used vouchers from United because our last trip with them was awful with many mishaps and errors made. Unfortunately, this trip was even worse!

Related info for your journey

Find useful and relevant information for your journey from Knoxville to Chicago. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airport do you fly from for flights from Knoxville to Chicago?

    If you book a flight to Chicago from Knoxville, you will be flying from McGhee Tyson, which is the city’s only airport. Knoxville McGhee Tyson (TYS) is located 11.3 mi from the center of Knoxville. There are 26 flights from McGhee Tyson to Chicago per day from 4 different airlines.

  • How long is the flight from Knoxville to Chicago?

    There are many flights that can get you from Knoxville to Chicago in 1h 32m. Fly via Allegiant Air, United Airlines, or Delta to get the fastest option. The distance from Knoxville to Chicago is about 460 mi. This flight may include one or multiple stops.

  • What are the cheapest airlines flying from Knoxville to Chicago round-trip?

    Our cheapest airline available from Knoxville to Chicago is Allegiant Air. Our recent data shows that you can find tickets from as low as $60 on this airline. Additional options worth looking into are American Airlines and United Airlines, starting at $186 and $189 round-trip. Allegiant Air is currently priced 76% below the average price you’ll pay for this route.

  • What are the most reliable airlines from Knoxville to Chicago?

    The top 3 most reliable airlines when flying from Knoxville to Chicago are Avianca (92%), ANA (83%) and Envoy Air (79%).

  • What are the cheapest flights from Knoxville to Chicago?

    On average you can expect to pay $1,088 for a flight from Knoxville to Chicago. The cheapest flight overall is $128 while the most popular route, (Knoxville McGhee Tyson - Chicago O'Hare Intl) is currently priced at $189.

  • Can I find deals for flights from Knoxville to Chicago that include hotel bookings?

    Yes. In addition to deals on Knoxville to Chicago flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Knoxville to Chicago?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Knoxville to Chicago.

  • Can I find deals for business class flights from Knoxville to Chicago?

    Yes. Cheapflights offers flight deals from Knoxville to Chicago by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Knoxville to Chicago?

    Currently, August is the cheapest month in which you can book a flight from Knoxville to Chicago (average of $245). Flying from Knoxville to Chicago in March is currently the most expensive (average of $321). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Traveling to a place near Chicago?

Book flights to Chicago if you plan to visit one of these locations
Merrillville
Lansing
Hammond
Benton Harbor
Porter
Chesterton

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Top 4 airlines flying from Knoxville to Chicago

Discover the top 4 airlines that operate flights from Knoxville to Chicago. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated September 11, 2025.
AirlineCheapestAverageFlexibilityOn-time
Allegiant AirCheapest$60Average$90FlexibilityNo cancel feeOn-time88%
American AirlinesCheapest$186Average$259FlexibilityNo cancel feeOn-time71%
United AirlinesCheapest$189Average$306FlexibilityNo cancel feeOn-time69%
DeltaCheapest$233Average$373FlexibilityNo cancel feeOn-timeN/A

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