HomeSearch by dateVacation packagesHotelsFlight dealsCar rentalTravel tips & news
Chicago

$102+ Cheap flights from Knoxville (TYS) to Chicago (CHI)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 1/12. Fares are subject to change and may not be available on all flights or dates of travel.
TYS — CHI
Jan 15 — Jan 221
Thu 1/15
Thu 1/22
1 adult, Economy
We work with more than 300 partners to bring you better travel deals

Find cheap flights from Knoxville to Chicago with Cheapflights

1. Tell us where you want to go

Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”

2. Select your favorite providers

We find the providers serving your travel needs. Choose up to four travel providers to compare side-by-side for flights, hotels, or car rentals.

3. Compare prices and book

Review each provider’s pricing and select the best option for you! Book through your favorite provider’s website for a seamless experience.

Cheapflights Tip: The best prices from Knoxville McGhee Tyson to Chicago are usually found in February or August, booked 73 days in advance, depart on a Friday or Thursday and return on a Saturday

Cheap flight deals from Knoxville to Chicago

Cheapest flights from Knoxville to Chicago
Explore the most affordable flight options available from Knoxville to Chicago. Find the lowest fares from popular airlines and budget airlines, with prices last updated on December 16, 2025.

This United Airlines deal was found by Cheapflights users on 12/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 12/306:45 amTYS - ORD
Nonstop2h 07mUnited Airlines
Sat 1/32:07 pmORD - TYS
Nonstop1h 53mUnited Airlines
Deal found 12/15$219
This American Airlines deal was found by Cheapflights users on 12/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/317:35 amTYS - ORD
1 stop7h 15mAmerican Airlines
Fri 1/28:00 amORD - TYS
Nonstop1h 50mAmerican Airlines
Deal found 12/15$239
This American Airlines deal was found by Cheapflights users on 12/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 12/295:08 pmTYS - ORD
Nonstop2h 12mAmerican Airlines
Fri 1/211:41 amORD - TYS
Nonstop1h 50mAmerican Airlines
Deal found 12/14$249
This United Airlines deal was found by Cheapflights users on 12/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/246:45 amTYS - ORD
Nonstop2h 07mUnited Airlines
Mon 12/297:48 pmORD - TYS
Nonstop1h 51mUnited Airlines
Deal found 12/15$257
This American Airlines deal was found by Cheapflights users on 12/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 12/295:42 amTYS - ORD
1 stop5h 21mAmerican Airlines
Sun 1/48:00 amORD - TYS
Nonstop1h 50mAmerican Airlines
Deal found 12/16$259
This American Airlines deal was found by Cheapflights users on 12/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 12/295:08 pmTYS - ORD
Nonstop2h 12mAmerican Airlines
Sat 1/36:33 pmORD - TYS
Nonstop1h 48mAmerican Airlines
Deal found 12/16$279
This American Airlines deal was found by Cheapflights users on 12/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 12/205:08 pmTYS - ORD
Nonstop2h 12mAmerican Airlines
Mon 12/226:40 amORD - TYS
1 stop8h 07mAmerican Airlines
Deal found 12/15$304
This United Airlines deal was found by Cheapflights users on 12/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 12/266:45 amTYS - ORD
Nonstop2h 07mUnited Airlines
Sun 12/287:48 pmORD - TYS
Nonstop1h 51mUnited Airlines
Deal found 12/16$308
This United Airlines deal was found by Cheapflights users on 12/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 12/1610:50 amTYS - ORD
Nonstop2h 01mUnited Airlines
Sat 12/207:48 pmORD - TYS
Nonstop1h 51mUnited Airlines
Deal found 12/15$309
This American Airlines deal was found by Cheapflights users on 12/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 12/166:29 pmTYS - ORD
Nonstop2h 04mAmerican Airlines
Sat 12/201:54 pmORD - TYS
1 stop4h 05mAmerican Airlines
Deal found 12/15$319
This Kiwi.com deal was found by Cheapflights users on 12/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/257:15 amTYS - MDW
1 stop6h 46mMultiple Airlines
Sat 1/36:12 amMDW - TYS
2 stops48h 51mMultiple Airlines
Deal found 12/16$377
This Delta deal was found by Cheapflights users on 12/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 12/296:59 pmTYS - MDW
1 stop4h 23mDelta
Sun 1/412:45 pmMDW - TYS
1 stop4h 29mDelta
Deal found 12/16$439

Find flight deals from Knoxville to Chicago

Discover tips and strategies to find the most affordable flight options for your journey from Knoxville (TYS) to Chicago (CHI). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated December 16, 2025.

Most accurate provider

Mytrip
3 stars

Most trusted provider

Mytrip
3 stars

Round-trip from

$140
(Kiwi.com)

One-way from

$102
(Kiwi.com)

Popular in

December

Cheapest in

February

Average price

$336

Good round-trip deal

$337 or less

Good one-way deal

$83 or less
Provider with most accurate pricing for Knoxville McGhee Tyson-Chicago (CHI) flight deals.
Search Deals
Provider most trusted by Cheapflights users for Knoxville McGhee Tyson-Chicago (CHI) flights.
Search Deals
From Knoxville McGhee Tyson to Chicago (CHI)
Search Deals
One-way flight from Knoxville McGhee Tyson to Chicago (CHI)
Search Deals
Highest demand for flights based on searches. 8% potential increase in price ($23 potential increase over avg. RT price).
Search Deals
Cheapest flight prices on average. 2% potential price decrease ($7 potential savings vs. average RT price).
Search Deals
Average for round-trip flights in December 2025
Search Deals
Price to beat on a round-trip flight from Knoxville McGhee Tyson to Chicago (CHI).
Search Deals
Price to beat on a one-way flight from Knoxville McGhee Tyson to Chicago (CHI).
Search Deals

Cheapflights Fare Finder

 
Customize your flight search to find flights from Knoxville to Chicago that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated December 16, 2025.
Use the filters below to find and compare flights from Knoxville to Chicago that are best for you.

Fly from

Knoxville

Fly to

Chicago

Route

Depart

Return

Price

KnoxvilleChicago

TYS - ORD

TYSORD

Knoxville McGhee Tyson

Fri 1/9

11:07 am-12:05 pm

Nonstop1h 58m

Chicago O'Hare Intl

Mon 1/12

7:42 am-10:32 am

Nonstop1h 50m

$189

KnoxvilleChicago

TYS - ORD

TYSORD

Knoxville McGhee Tyson

Thu 2/26

11:16 am-12:19 pm

Nonstop2h 03m

Chicago O'Hare Intl

Mon 3/2

8:00 am-10:43 am

Nonstop1h 43m

$189

KnoxvilleChicago

TYS - ORD

TYSORD

Knoxville McGhee Tyson

Thu 1/8

11:07 am-12:05 pm

Nonstop1h 58m

Chicago O'Hare Intl

Mon 1/12

6:10 pm-8:52 pm

Nonstop1h 42m

$189

KnoxvilleChicago

TYS - ORD

TYSORD

Knoxville McGhee Tyson

Thu 1/22

1:59 pm-2:55 pm

Nonstop1h 56m

Chicago O'Hare Intl

Sun 1/25

6:10 pm-8:52 pm

Nonstop1h 42m

$189

KnoxvilleChicago

TYS - ORD

TYSORD

Knoxville McGhee Tyson

Thu 1/15

6:45 am-7:48 am

Nonstop2h 03m

Chicago O'Hare Intl

Sat 1/17

7:42 am-10:32 am

Nonstop1h 50m

$189

KnoxvilleChicago

TYS - ORD

TYSORD

Knoxville McGhee Tyson

Fri 2/20

6:45 am-7:47 am

Nonstop2h 02m

Chicago O'Hare Intl

Wed 2/25

6:15 pm-8:57 pm

Nonstop1h 42m

$189

KnoxvilleChicago

TYS - ORD

TYSORD

Knoxville McGhee Tyson

Tue 1/6

5:29 pm-6:27 pm

Nonstop1h 58m

Chicago O'Hare Intl

Sat 1/10

7:42 am-10:32 am

Nonstop1h 50m

$189

KnoxvilleChicago

TYS - ORD

TYSORD

Knoxville McGhee Tyson

Thu 1/8

11:07 am-12:05 pm

Nonstop1h 58m

Chicago O'Hare Intl

Sun 1/11

6:10 pm-8:52 pm

Nonstop1h 42m

$189

KnoxvilleChicago

TYS - ORD

TYSORD

Knoxville McGhee Tyson

Tue 1/13

1:59 pm-2:55 pm

Nonstop1h 56m

Chicago O'Hare Intl

Tue 1/20

6:10 pm-8:52 pm

Nonstop1h 42m

$189

KnoxvilleChicago

TYS - ORD

TYSORD

Knoxville McGhee Tyson

Wed 1/7

3:53 pm-2:22 pm

2 stops23h 29m

Chicago O'Hare Intl

Sun 1/11

8:27 pm-10:10 am

1 stop12h 43m

$207

Flights are sorted by cheapest round-trip flights first.

Deals found on 12/15

Showing 1-10 of 39 results
1
2
3
4

Compare providers for flights from Knoxville to Chicago

Provider information is updated monthly. Please note that these providers often have deals for this flight, but the availability may vary on a day-by-day basis on Cheapflights.
Use the table below to compare price accuracy, trust ratings, and cancellation policies for each provider offering flight deals from Knoxville to Chicago in December.
ProviderPrice AccuracyTrust Score*
ExpediaPrice Accuracy2 starsTrust Score*3 stars
FlightHubPrice Accuracy3 starsTrust Score*1 star
eDreamsPrice Accuracy3 starsTrust Score*3 stars
MytripPrice Accuracy3 starsTrust Score*3 stars

*The Trust Score is based on feedback from users after their booking experience. It measures overall satisfaction, helping us identify issues like hidden fees, problems during the ticketing process, and the quality of customer service. This score is our best indicator of the provider's quality and reliability.

  • Most accurate provider: When it comes to deals on Knoxville-Chicago flights, users find the pricing of Mytrip to be most consistent on Cheapflights vs. Mytrip Users can find the same prices on Knoxville-Chicago flight deals on Cheapflights vs. Mytrip >95% of the time. Price accuracy is based on data collected from Knoxville-Chicago flight searches over the past month and is updated monthly.
  • Most trusted provider: When it comes to deals on Knoxville-Chicago flights, Cheapflights users trust Mytrip the most. Mytrip has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for Knoxville-Chicago flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.

Best time to book a flight from Knoxville to Chicago

Have a flexible travel schedule? Discover the best time to fly to Chicago from Knoxville with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Knoxville to Chicago

How far ahead should I book a flight from Knoxville to Chicago?

Use this chart to determine the optimal time to book a round-trip flight from Knoxville to Chicago. Price data was last updated on December 12, 2025.

The best time to book flights from Knoxville to Chicago is 72 days before your desired departure date. The cost of your flight will likely increase significantly if you book two weeks in advance of your flight.

What is the cheapest month to book a flight from Knoxville to Chicago?

Currently, August is the cheapest month in which you can book a flight from Knoxville to Chicago (average of $58). Flying from Knoxville to Chicago in February is currently the most expensive (average of $189). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from TYS to CHI?

Find hourly flight availability from Knoxville to Chicago. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated December 16, 2025.

It’s typically best to fly out from Knoxville to Chicago in the morning. Doing so could potentially save you 36% on the flight price compared to flying in the evening, which is usually more expensive.

What is the cheapest day to fly from Knoxville to Chicago?

Use this chart to determine the cheapest time to fly round-trip from Knoxville to Chicago. Price data was last updated on December 13, 2025.

Travelers seeking maximum savings on their Knoxville to Chicago flight should consider departing on Wednesday at noon when fares are most often at their lowest. Saturday evenings flights should be avoided if possible as fares are typically the most expensive at this time.

How much does it cost to fly round-trip from Knoxville to Chicago?

Reviews of airlines servicing Chicago

Get insights into the airlines that provide service to Chicago. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Chicago. Reviews last updated December 16, 2025.
Peruse reviews from past customers who have flown with United Airlines, American Airlines, and Allegiant Air from Knoxville to Chicago to help guide your decision. You can also see how each airline stacks up in terms of entertainment options, comfort, food, crew/service, and boarding process.
United Airlines
7.4
Good
9,094 reviews

Food

6.6

Entertainment

7.1

Boarding

7.7

Comfort

7.3

Overall

7.4

Crew

8.1

Reviews

1 / 20
8.0
Excellent

Anonymous,Oct 2025

YUL - ORD

Crew and customer service are 5 stars. I had a lot of luggage for a very long trip and they were nothing but helpful and found solutions to every problem. It was my first time flying with United, and they really are the friendly skies. Leg room however, on 2/3 flights was terrible. Same for entertainment: There was only a seat-mounted screen on 1/3 flights. It would have been nice to have on the longest leg of the journey.
United Airlines
7.4
Good
9,094 reviews
United Airlines
7.4
Good
9,094 reviews

Food

6.6

Entertainment

7.1

Boarding

7.7

Comfort

7.3

Overall

7.4

Crew

8.1

Reviews

1 / 20
8.0
Excellent

Anonymous,Oct 2025

YUL - ORD

Crew and customer service are 5 stars. I had a lot of luggage for a very long trip and they were nothing but helpful and found solutions to every problem. It was my first time flying with United, and they really are the friendly skies. Leg room however, on 2/3 flights was terrible. Same for entertainment: There was only a seat-mounted screen on 1/3 flights. It would have been nice to have on the longest leg of the journey.
American Airlines
7.2
Good
11,047 reviews
United Airlines
7.4
Good
9,094 reviews

Food

6.6

Entertainment

7.1

Boarding

7.7

Comfort

7.3

Overall

7.4

Crew

8.1

Reviews

1 / 20
8.0
Excellent

Anonymous,Oct 2025

YUL - ORD

Crew and customer service are 5 stars. I had a lot of luggage for a very long trip and they were nothing but helpful and found solutions to every problem. It was my first time flying with United, and they really are the friendly skies. Leg room however, on 2/3 flights was terrible. Same for entertainment: There was only a seat-mounted screen on 1/3 flights. It would have been nice to have on the longest leg of the journey.
Allegiant Air
7.2
Good
700 reviews
United Airlines
7.4
Good
9,094 reviews

Food

6.6

Entertainment

7.1

Boarding

7.7

Comfort

7.3

Overall

7.4

Crew

8.1

Reviews

1 / 20
8.0
Excellent

Anonymous,Oct 2025

YUL - ORD

Crew and customer service are 5 stars. I had a lot of luggage for a very long trip and they were nothing but helpful and found solutions to every problem. It was my first time flying with United, and they really are the friendly skies. Leg room however, on 2/3 flights was terrible. Same for entertainment: There was only a seat-mounted screen on 1/3 flights. It would have been nice to have on the longest leg of the journey.

Related info for your journey

Find useful and relevant information for your journey from Knoxville to Chicago. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airport do you fly from for flights from Knoxville to Chicago?

    If you book a flight to Chicago from Knoxville, you will be flying from McGhee Tyson, which is the city’s only airport. Knoxville McGhee Tyson (TYS) is located 11.3 mi from the center of Knoxville. There are 10 flights from McGhee Tyson to Chicago per day from 4 different airlines.

  • How long is the flight from Knoxville to Chicago?

    There are many flights that can get you from Knoxville to Chicago in 1h 58m. Fly via United Airlines or Delta to get the fastest option. The distance from Knoxville to Chicago is about 475 mi. This flight may include one or multiple stops.

  • What are the cheapest airlines flying from Knoxville to Chicago round-trip?

    Our cheapest airline available from Knoxville to Chicago is Allegiant Air. Our recent data shows that you can find tickets from as low as $60 on this airline. Additional options worth looking into are American Airlines and United Airlines, starting at $189 and $189 round-trip. Allegiant Air is currently priced 77% below the average price you’ll pay for this route.

  • What are the cheapest airlines to fly from Knoxville to Chicago one-way?

    The cheapest airline one-way is Allegiant Air, with whom users have recently found tickets for as low as $49. However, be on the lookout for offers from American Airlines and United Airlines, as they are both options that can get you from Knoxville to Chicago for a low price.

  • What are the most reliable airlines from Knoxville to Chicago?

    The top 3 most reliable airlines when flying from Knoxville to Chicago are Republic Airways (100%), ANA (74%) and United Airlines (70%).

  • What are the cheapest flights from Knoxville to Chicago?

    On average you can expect to pay $979 for a flight from Knoxville to Chicago. The cheapest flight overall is $162 while the most popular route, (Knoxville McGhee Tyson - Chicago O'Hare Intl) is currently priced at $189.

  • Can I find deals for flights from Knoxville to Chicago that include hotel bookings?

    Yes. In addition to deals on Knoxville to Chicago flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Knoxville to Chicago?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Knoxville to Chicago.

  • Can I find deals for business class flights from Knoxville to Chicago?

    Yes. Cheapflights offers flight deals from Knoxville to Chicago by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Knoxville to Chicago?

    Currently, August is the cheapest month in which you can book a flight from Knoxville to Chicago (average of $58). Flying from Knoxville to Chicago in February is currently the most expensive (average of $189). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Traveling to a place near Chicago?

Book flights to Chicago if you plan to visit one of these locations
Lansing
Merrillville
Hammond
Porter
Benton Harbor

Browse thousands of different options on Cheapflights for your next trip

Toggle through the tabs below to find thousands of options on Cheapflights for your next trip.

Alternative routes for Knoxville to Chicago

See prices for flight routes from nearby airports that may be better suited for you.
Nashville to O'Hare Intl flights
Nashville to Midway flights
Memphis to O'Hare Intl flights
Chattanooga to O'Hare Intl flights
Knoxville to O'Hare Intl flights
Memphis to Midway flights
Chattanooga to Midway flights
Nashville to St. Louis flights
Knoxville to Midway flights
Nashville to Rockford flights
Knoxville to St. Louis flights
Blountville to O'Hare Intl flights
Chattanooga to St. Louis flights
Nashville to Moline flights
Knoxville to Peoria flights
Memphis to Peoria flights
Chattanooga to Peoria flights
Chattanooga to Moline flights
Memphis to St. Louis flights
Blountville to Midway flights
Memphis to Bloomington flights
Knoxville to Bloomington flights
Memphis to Moline flights
Knoxville to Moline flights
Nashville to Paducah flights
Nashville to Dubuque flights
Blountville to St. Louis flights
Memphis to Springfield flights
Nashville to Springfield flights
Jackson to St. Louis flights
Nashville to Quincy flights
Blountville to Bloomington flights
Chattanooga to Champaign flights

Top 4 airlines flying from Knoxville to Chicago

Discover the top 4 airlines that operate flights from Knoxville to Chicago. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated December 16, 2025.
AirlineCheapestAverageFlexibilityOn-time
Allegiant AirCheapest$60Average$103FlexibilityNo cancel feeOn-time88%
United AirlinesCheapest$189Average$318FlexibilityNo cancel feeOn-time69%
American AirlinesCheapest$189Average$269FlexibilityNo cancel feeOn-time71%
DeltaCheapest$258Average$373FlexibilityNo cancel feeOn-timeN/A

100% Free

Cheapflights is completely free to use, so you can start saving the moment you arrive.

Book with Flexibility

Our users can plan ahead with confidence and find flights with no change fees

Travel Smart

Millions of people come to us for their flight needs every year. We help make travel planning easy by providing useful insights and data-driven graphs that can inform your decisions.