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$133+ Cheap flights from Knoxville to Charleston (TYS - CHS)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 11/18. Fares are subject to change and may not be available on all flights or dates of travel.
TYS — CHS
Dec 4 — Dec 111
Thu 12/4
Thu 12/11
1 adult, Economy
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Find flight deals from Knoxville to Charleston

Cheapest flights from Knoxville to Charleston
Explore the most affordable flight options available from Knoxville to Charleston. Find the lowest fares from popular airlines and budget airlines, with prices last updated on November 4, 2025.

This Mytrip deal was found by Cheapflights users on 11/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 12/59:23 amTYS - CHS
1 stop11h 31mMultiple Airlines
Sun 12/79:49 pmCHS - TYS
1 stop10h 44mMultiple Airlines
Deal found 11/3$251
This Kiwi.com deal was found by Cheapflights users on 11/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/316:07 pmTYS - CHS
1 stop27h 16mMultiple Airlines
Sun 1/410:18 pmCHS - TYS
1 stop9h 45mMultiple Airlines
Deal found 11/4$252
This Kiwi.com deal was found by Cheapflights users on 11/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 12/111:29 amTYS - CHS
1 stop21h 08mMultiple Airlines
Mon 12/83:33 pmCHS - TYS
1 stop6h 16mMultiple Airlines
Deal found 11/3$296
This Kiwi.com deal was found by Cheapflights users on 11/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 12/151:05 pmTYS - CHS
1 stop19h 32mMultiple Airlines
Fri 12/193:33 pmCHS - TYS
1 stop6h 20mMultiple Airlines
Deal found 11/3$303
This Delta deal was found by Cheapflights users on 11/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 12/25:40 amTYS - CHS
1 stop6h 05mDelta
Tue 12/99:00 amCHS - TYS
1 stop4h 44mDelta
Deal found 11/4$327
This Mytrip deal was found by Cheapflights users on 11/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 11/1811:24 amTYS - CHS
3 stops29h 42mMultiple Airlines
Sat 11/226:15 pmCHS - TYS
3 stops21h 48mMultiple Airlines
Deal found 11/3$356
This Kiwi.com deal was found by Cheapflights users on 11/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/189:08 amTYS - CHS
1 stop12h 15mMultiple Airlines
Sat 12/209:09 pmCHS - TYS
2 stops24h 47mMultiple Airlines
Deal found 11/3$377

Cheap flight deals from Knoxville to Charleston

Discover tips and strategies to find the most affordable flight options for your journey from Knoxville (TYS) to Charleston (CHS). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated November 4, 2025.

Most accurate provider

eDreams
3 stars

Most trusted provider

eDreams
3 stars

Round-trip from

$193
(Kiwi.com)

One-way from

$133
(Kiwi.com)

Popular in

October

Cheapest in

August

Average price

$598
Provider with most accurate pricing for Knoxville McGhee Tyson-Charleston flight deals.
Search Deals
Provider most trusted by Cheapflights users for Knoxville McGhee Tyson-Charleston flights.
Search Deals
From Knoxville McGhee Tyson to Charleston
Search Deals
One-way flight from Knoxville McGhee Tyson to Charleston
Search Deals
Highest demand for flights based on searches. 16% potential increase in price ($89 potential increase over avg. RT price).
Search Deals
Cheapest flight prices on average. 4% potential price decrease ($21 potential savings vs. average RT price).
Search Deals
Average for round-trip flights in November 2025
Search Deals

Cheapflights Fare Finder

 
Customize your flight search to find flights from Knoxville to Charleston that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated November 4, 2025.
Use the filters below to find and compare flights from Knoxville to Charleston that are best for you.

Fly from

Knoxville

Fly to

Charleston

Route

Depart

Return

Price

KnoxvilleCharleston

TYS - CHS

TYSCHS

Knoxville McGhee Tyson

Wed 1/21

4:47 pm-10:45 am

1 stop17h 58m

Charleston

Sat 1/24

5:40 pm-8:39 am

1 stop14h 59m

$193

KnoxvilleCharleston

TYS - CHS

TYSCHS

Knoxville McGhee Tyson

Wed 2/4

4:47 pm-10:45 am

1 stop17h 58m

Charleston

Sat 2/7

5:40 pm-8:39 am

1 stop14h 59m

$197

KnoxvilleCharleston

TYS - CHS

TYSCHS

Knoxville McGhee Tyson

Thu 1/22

9:29 am-8:34 am

2 stops23h 05m

Charleston

Sun 1/25

5:40 pm-12:05 pm

2 stops18h 25m

$249

KnoxvilleCharleston

TYS - CHS

TYSCHS

Knoxville McGhee Tyson

Fri 12/5

9:23 am-8:54 pm

1 stop11h 31m

Charleston

Sun 12/7

9:49 pm-8:33 am

1 stop10h 44m

$251

KnoxvilleCharleston

TYS - CHS

TYSCHS

Knoxville McGhee Tyson

Wed 12/31

6:07 pm-9:23 pm

1 stop27h 16m

Charleston

Sun 1/4

10:18 pm-8:03 am

1 stop9h 45m

$252

KnoxvilleCharleston

TYS - CHS

TYSCHS

Knoxville McGhee Tyson

Mon 12/1

11:29 am-8:37 am

1 stop21h 08m

Charleston

Mon 12/8

3:33 pm-9:49 pm

1 stop6h 16m

$296

KnoxvilleCharleston

TYS - CHS

TYSCHS

Knoxville McGhee Tyson

Mon 12/15

1:05 pm-8:37 am

1 stop19h 32m

Charleston

Fri 12/19

3:33 pm-9:53 pm

1 stop6h 20m

$303

KnoxvilleCharleston

TYS - CHS

TYSCHS

Knoxville McGhee Tyson

Tue 11/18

4:04 pm-5:06 pm

2 stops25h 02m

$133

KnoxvilleCharleston

TYS - CHS

TYSCHS

Knoxville McGhee Tyson

Fri 12/12

1:05 pm-11:00 am

2 stops21h 55m

$150

KnoxvilleCharleston

TYS - CHS

TYSCHS

Knoxville McGhee Tyson

Sat 12/13

8:32 pm-3:53 pm

3 stops43h 21m

$224

Flights are sorted by cheapest round-trip flights first.

Deals found on 11/3

Showing 1-10 of 13 results
1
2

Compare providers for flights from Knoxville to Charleston

Provider information is updated monthly. Please note that these providers often have deals for this flight, but the availability may vary on a day-by-day basis on Cheapflights.
Use the table below to compare price accuracy, trust ratings, and cancellation policies for each provider offering flight deals from Knoxville to Charleston in November.
ProviderPrice AccuracyTrust Score*
ExpediaPrice Accuracy2 starsTrust Score*3 stars
FlightHubPrice Accuracy3 starsTrust Score*1 star
eDreamsPrice Accuracy3 starsTrust Score*3 stars

*The Trust Score is based on feedback from users after their booking experience. It measures overall satisfaction, helping us identify issues like hidden fees, problems during the ticketing process, and the quality of customer service. This score is our best indicator of the provider's quality and reliability.

  • Most accurate provider: When it comes to deals on Knoxville-Charleston flights, users find the pricing of eDreams to be most consistent on Cheapflights vs. eDreams Users can find the same prices on Knoxville-Charleston flight deals on Cheapflights vs. eDreams >95% of the time. Price accuracy is based on data collected from Knoxville-Charleston flight searches over the past month and is updated monthly.
  • Most trusted provider: When it comes to deals on Knoxville-Charleston flights, Cheapflights users trust eDreams the most. eDreams has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for Knoxville-Charleston flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.

Best time to book a flight from Knoxville to Charleston

Have a flexible travel schedule? Discover the best time to fly to Charleston from Knoxville with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Knoxville to Charleston

What is the cheapest month to book a flight from Knoxville to Charleston?

Currently, June is the cheapest month in which you can book a flight from Knoxville to Charleston (average of $174). Flying from Knoxville to Charleston in October is currently the most expensive (average of $279). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from TYS to CHS?

Find hourly flight availability from Knoxville to Charleston. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated November 4, 2025.

When flying from Knoxville to Charleston, the time of day you fly usually plays a role in the price. Save by searching for a flight in the morning, which can drop the price by up to 18% versus a flight in the afternoon.

Reviews of airlines servicing Charleston

Get insights into the airlines that provide service to Charleston. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Charleston. Reviews last updated November 4, 2025.
Peruse reviews from past customers who have flown with Delta and American Airlines from Knoxville to Charleston to help guide your decision. You can also see how each airline stacks up in terms of entertainment options, comfort, food, crew/service, and boarding process.
Delta
7.9
Good
8,003 reviews

Crew

8.5

Overall

7.9

Entertainment

7.9

Food

7.3

Comfort

7.9

Boarding

8.2

Reviews

1 / 20
6.0
Good

Jim,Nov 2025

AVL - ATL

The exit row seats without a seat in front are great for leg room but don’t have a fold out entertainment console so you’re forced to use the screen several feet in front of you (there is, at least, a remote). Best to bring a tablet loaded with entertainment or a book.
Delta
7.9
Good
8,003 reviews
Delta
7.9
Good
8,003 reviews

Crew

8.5

Overall

7.9

Entertainment

7.9

Food

7.3

Comfort

7.9

Boarding

8.2

Reviews

1 / 20
6.0
Good

Jim,Nov 2025

AVL - ATL

The exit row seats without a seat in front are great for leg room but don’t have a fold out entertainment console so you’re forced to use the screen several feet in front of you (there is, at least, a remote). Best to bring a tablet loaded with entertainment or a book.
American Airlines
7.2
Good
11,040 reviews
Delta
7.9
Good
8,003 reviews

Crew

8.5

Overall

7.9

Entertainment

7.9

Food

7.3

Comfort

7.9

Boarding

8.2

Reviews

1 / 20
6.0
Good

Jim,Nov 2025

AVL - ATL

The exit row seats without a seat in front are great for leg room but don’t have a fold out entertainment console so you’re forced to use the screen several feet in front of you (there is, at least, a remote). Best to bring a tablet loaded with entertainment or a book.

Related info for your journey

Find useful and relevant information for your journey from Knoxville to Charleston. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What are the cheapest airlines flying from Knoxville to Charleston round-trip?

    Currently priced at $296, American Airlines will fly you from Knoxville to Charleston and back. In addition to American Airlines, many other airlines offer competitively priced options for your trip. Check Cheapflights for deals on Delta for as low as $316. You may be able to fly from Knoxville to Charleston for 36% less than the average price by searching for these airlines.

  • Can I find deals for flights from Knoxville to Charleston that include hotel bookings?

    Yes. In addition to deals on Knoxville to Charleston flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Knoxville to Charleston?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Knoxville to Charleston.

  • Can I find deals for business class flights from Knoxville to Charleston?

    Yes. Cheapflights offers flight deals from Knoxville to Charleston by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Knoxville to Charleston?

    Currently, June is the cheapest month in which you can book a flight from Knoxville to Charleston (average of $174). Flying from Knoxville to Charleston in October is currently the most expensive (average of $279). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Traveling to a place near Charleston?

Book flights to Charleston if you plan to visit one of these locations
North Charleston
Summerville
Walterboro
Isle of Palms
Santee
Mount Pleasant
Edisto Beach

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Top 2 airlines flying from Knoxville to Charleston

Discover the top 2 airlines that operate flights from Knoxville to Charleston. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated November 4, 2025.
AirlineCheapestAverageFlexibilityOn-time
American AirlinesCheapest$296Average$417FlexibilityNo cancel feeOn-time71%
DeltaCheapest$316Average$458FlexibilityNo cancel feeOn-timeN/A

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