HomeSearch by dateVacation packagesHotelsFlight dealsCar rentalTravel tips & news
Charleston

$92+ Cheap flights from Knoxville to Charleston (TYS - CHS)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 11/27. Fares are subject to change and may not be available on all flights or dates of travel.
TYS — CHS
Dec 18 — Dec 251
Thu 12/18
Thu 12/25
1 adult, Economy
We work with more than 300 partners to bring you better travel deals

Find cheap flights from Knoxville to Charleston with Cheapflights

1. Tell us where you want to go

Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”

2. Select your favorite providers

We find the providers serving your travel needs. Choose up to four travel providers to compare side-by-side for flights, hotels, or car rentals.

3. Compare prices and book

Review each provider’s pricing and select the best option for you! Book through your favorite provider’s website for a seamless experience.

Find flight deals from Knoxville to Charleston

Cheapest flights from Knoxville to Charleston
Explore the most affordable flight options available from Knoxville to Charleston. Find the lowest fares from popular airlines and budget airlines, with prices last updated on November 18, 2025.

This Kiwi.com deal was found by Cheapflights users on 11/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 12/59:23 amTYS - CHS
1 stop11h 31mMultiple Airlines
Mon 12/83:33 pmCHS - TYS
1 stop6h 16mMultiple Airlines
Deal found 11/18$265
This Kiwi.com deal was found by Cheapflights users on 11/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 12/85:34 pmTYS - CHS
1 stop15h 03mMultiple Airlines
Sat 12/138:10 pmCHS - TYS
2 stops25h 27mMultiple Airlines
Deal found 11/17$272
This Kiwi.com deal was found by Cheapflights users on 11/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 12/2810:04 pmTYS - CHS
1 stop10h 53mMultiple Airlines
Mon 12/2910:18 pmCHS - TYS
1 stop10h 00mMultiple Airlines
Deal found 11/18$301
This Mytrip deal was found by Cheapflights users on 11/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/312:53 pmTYS - CHS
2 stops22h 07mMultiple Airlines
Sun 12/79:49 pmCHS - TYS
1 stop10h 44mMultiple Airlines
Deal found 11/18$314
This Kiwi.com deal was found by Cheapflights users on 11/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 12/77:11 pmTYS - CHS
1 stop25h 43mMultiple Airlines
Sat 12/133:09 pmCHS - TYS
2 stops31h 33mMultiple Airlines
Deal found 11/16$322
This Mytrip deal was found by Cheapflights users on 11/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/1012:53 pmTYS - CHS
2 stops22h 07mMultiple Airlines
Sun 12/149:49 pmCHS - TYS
1 stop10h 44mMultiple Airlines
Deal found 11/17$330
This Delta deal was found by Cheapflights users on 11/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 12/77:59 pmTYS - CHS
1 stop3h 57mDelta
Sat 12/135:00 pmCHS - TYS
1 stop3h 10mDelta
Deal found 11/16$347
This Mytrip deal was found by Cheapflights users on 11/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/172:53 pmTYS - CHS
2 stops22h 17mMultiple Airlines
Sun 12/2110:18 pmCHS - TYS
1 stop10h 00mMultiple Airlines
Deal found 11/17$352
This Kiwi.com deal was found by Cheapflights users on 11/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 11/238:30 amTYS - CHS
1 stop24h 27mMultiple Airlines
Wed 11/269:08 pmCHS - TYS
2 stops20h 21mMultiple Airlines
Deal found 11/18$356

Cheap flight deals from Knoxville to Charleston

Discover tips and strategies to find the most affordable flight options for your journey from Knoxville (TYS) to Charleston (CHS). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated November 18, 2025.

Most accurate provider

eDreams
3 stars

Most trusted provider

eDreams
3 stars

Round-trip from

$272
(Kiwi.com)

One-way from

$92
(Trip.com)

Popular in

December

Cheapest in

August

Average price

$462
Provider with most accurate pricing for Knoxville McGhee Tyson-Charleston flight deals.
Search Deals
Provider most trusted by Cheapflights users for Knoxville McGhee Tyson-Charleston flights.
Search Deals
From Knoxville McGhee Tyson to Charleston
Search Deals
One-way flight from Knoxville McGhee Tyson to Charleston
Search Deals
Highest demand for flights based on searches. 20% potential increase in price ($121 potential increase over avg. RT price).
Search Deals
Cheapest flight prices on average. 6% potential price decrease ($27 potential savings vs. average RT price).
Search Deals
Average for round-trip flights in November 2025
Search Deals

Cheapflights Fare Finder

 
Customize your flight search to find flights from Knoxville to Charleston that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated November 18, 2025.
Use the filters below to find and compare flights from Knoxville to Charleston that are best for you.

Fly from

Knoxville

Fly to

Charleston

Route

Depart

Return

Price

KnoxvilleCharleston

TYS - CHS

TYSCHS

Knoxville McGhee Tyson

Mon 12/1

11:29 am-8:37 am

1 stop21h 08m

Charleston

Fri 12/5

9:49 pm-12:03 pm

1 stop14h 14m

$273

KnoxvilleCharleston

TYS - CHS

TYSCHS

Knoxville McGhee Tyson

Mon 12/22

5:38 pm-8:37 am

1 stop14h 59m

Charleston

Thu 12/25

10:18 pm-8:35 pm

1 stop22h 17m

$305

KnoxvilleCharleston

TYS - CHS

TYSCHS

Knoxville McGhee Tyson

Tue 1/6

5:40 am-11:48 am

1 stop6h 08m

Charleston

Tue 1/20

5:25 am-11:08 am

1 stop5h 43m

$307

KnoxvilleCharleston

TYS - CHS

TYSCHS

Knoxville McGhee Tyson

Wed 12/17

5:40 am-11:45 am

1 stop6h 05m

Charleston

Sun 12/21

5:25 am-9:17 am

1 stop3h 52m

$317

KnoxvilleCharleston

TYS - CHS

TYSCHS

Knoxville McGhee Tyson

Thu 1/8

9:29 am-5:36 pm

1 stop8h 07m

Charleston

Mon 1/12

9:23 am-12:10 pm

2 stops26h 47m

$319

KnoxvilleCharleston

TYS - CHS

TYSCHS

Knoxville McGhee Tyson

Thu 1/8

5:40 am-9:19 am

1 stop3h 39m

Charleston

Mon 1/12

7:00 pm-11:45 pm

1 stop4h 45m

$327

KnoxvilleCharleston

TYS - CHS

TYSCHS

Knoxville McGhee Tyson

Mon 12/29

6:00 am-8:37 am

1 stop26h 37m

Charleston

Mon 1/5

10:18 pm-6:32 pm

1 stop20h 14m

$334

KnoxvilleCharleston

TYS - CHS

TYSCHS

Knoxville McGhee Tyson

Wed 12/10

8:35 am-11:45 am

1 stop3h 10m

Charleston

Sat 12/13

5:00 pm-8:10 pm

1 stop3h 10m

$347

KnoxvilleCharleston

TYS - CHS

TYSCHS

Knoxville McGhee Tyson

Mon 12/8

7:59 pm-11:50 pm

1 stop3h 51m

Charleston

Sat 12/13

11:15 am-2:50 pm

1 stop3h 35m

$347

KnoxvilleCharleston

TYS - CHS

TYSCHS

Knoxville McGhee Tyson

Fri 12/12

5:40 am-9:27 am

1 stop3h 47m

Charleston

Mon 12/15

5:25 am-9:38 am

1 stop4h 13m

$347

Flights are sorted by cheapest round-trip flights first.

Deals found on 11/17

Showing 1-10 of 15 results
1
2

Compare providers for flights from Knoxville to Charleston

Provider information is updated monthly. Please note that these providers often have deals for this flight, but the availability may vary on a day-by-day basis on Cheapflights.
Use the table below to compare price accuracy, trust ratings, and cancellation policies for each provider offering flight deals from Knoxville to Charleston in November.
ProviderPrice AccuracyTrust Score*
ExpediaPrice Accuracy2 starsTrust Score*3 stars
FlightHubPrice Accuracy3 starsTrust Score*1 star
eDreamsPrice Accuracy3 starsTrust Score*3 stars

*The Trust Score is based on feedback from users after their booking experience. It measures overall satisfaction, helping us identify issues like hidden fees, problems during the ticketing process, and the quality of customer service. This score is our best indicator of the provider's quality and reliability.

  • Most accurate provider: When it comes to deals on Knoxville-Charleston flights, users find the pricing of eDreams to be most consistent on Cheapflights vs. eDreams Users can find the same prices on Knoxville-Charleston flight deals on Cheapflights vs. eDreams >95% of the time. Price accuracy is based on data collected from Knoxville-Charleston flight searches over the past month and is updated monthly.
  • Most trusted provider: When it comes to deals on Knoxville-Charleston flights, Cheapflights users trust eDreams the most. eDreams has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for Knoxville-Charleston flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.

Best time to book a flight from Knoxville to Charleston

Have a flexible travel schedule? Discover the best time to fly to Charleston from Knoxville with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Knoxville to Charleston

What is the cheapest month to book a flight from Knoxville to Charleston?

Currently, June is the cheapest month in which you can book a flight from Knoxville to Charleston (average of $174). Flying from Knoxville to Charleston in March is currently the most expensive (average of $267). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from TYS to CHS?

Find hourly flight availability from Knoxville to Charleston. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated November 18, 2025.

When flying from Knoxville to Charleston, the time of day you fly usually plays a role in the price. Save by searching for a flight in the morning, which can drop the price by up to 18% versus a flight in the afternoon.

Reviews of airlines servicing Charleston

Get insights into the airlines that provide service to Charleston. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Charleston. Reviews last updated November 18, 2025.
Peruse reviews from past customers who have flown with Delta and American Airlines from Knoxville to Charleston to help guide your decision. You can also see how each airline stacks up in terms of entertainment options, comfort, food, crew/service, and boarding process.
Delta
7.9
Good
8,003 reviews

Crew

8.5

Comfort

7.9

Food

7.3

Overall

7.9

Boarding

8.1

Entertainment

7.9

Reviews

1 / 20
6.0
Good

Jim,Nov 2025

AVL - ATL

The exit row seats without a seat in front are great for leg room but don’t have a fold out entertainment console so you’re forced to use the screen several feet in front of you (there is, at least, a remote). Best to bring a tablet loaded with entertainment or a book.
Delta
7.9
Good
8,003 reviews
Delta
7.9
Good
8,003 reviews

Crew

8.5

Comfort

7.9

Food

7.3

Overall

7.9

Boarding

8.1

Entertainment

7.9

Reviews

1 / 20
6.0
Good

Jim,Nov 2025

AVL - ATL

The exit row seats without a seat in front are great for leg room but don’t have a fold out entertainment console so you’re forced to use the screen several feet in front of you (there is, at least, a remote). Best to bring a tablet loaded with entertainment or a book.
American Airlines
7.2
Good
11,045 reviews
Delta
7.9
Good
8,003 reviews

Crew

8.5

Comfort

7.9

Food

7.3

Overall

7.9

Boarding

8.1

Entertainment

7.9

Reviews

1 / 20
6.0
Good

Jim,Nov 2025

AVL - ATL

The exit row seats without a seat in front are great for leg room but don’t have a fold out entertainment console so you’re forced to use the screen several feet in front of you (there is, at least, a remote). Best to bring a tablet loaded with entertainment or a book.

Related info for your journey

Find useful and relevant information for your journey from Knoxville to Charleston. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • How long is the flight from Knoxville to Charleston?

    A quick flight from Knoxville to Charleston can take about 6h 08m. Delta provides one of the quickest options available for as low as $307. The distance between Knoxville and Charleston is about 302 mi.

  • What are the cheapest airlines flying from Knoxville to Charleston round-trip?

    Currently priced at $296, American Airlines will fly you from Knoxville to Charleston and back. In addition to American Airlines, many other airlines offer competitively priced options for your trip. Check Cheapflights for deals on Delta for as low as $316. You may be able to fly from Knoxville to Charleston for 35% less than the average price by searching for these airlines.

  • Can I find deals for flights from Knoxville to Charleston that include hotel bookings?

    Yes. In addition to deals on Knoxville to Charleston flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Knoxville to Charleston?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Knoxville to Charleston.

  • Can I find deals for business class flights from Knoxville to Charleston?

    Yes. Cheapflights offers flight deals from Knoxville to Charleston by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Knoxville to Charleston?

    Currently, June is the cheapest month in which you can book a flight from Knoxville to Charleston (average of $174). Flying from Knoxville to Charleston in March is currently the most expensive (average of $267). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Traveling to a place near Charleston?

Book flights to Charleston if you plan to visit one of these locations
North Charleston
Summerville
Santee
Walterboro
Isle of Palms
Mount Pleasant
Edisto Beach

Browse thousands of different options on Cheapflights for your next trip

Toggle through the tabs below to find thousands of options on Cheapflights for your next trip.

Alternative routes for Knoxville to Charleston

See prices for flight routes from nearby airports that may be better suited for you.
Nashville to Savannah flights
Nashville to Charlotte flights
Chattanooga to Charlotte flights
Nashville to Charleston flights
Memphis to Charlotte flights
Memphis to Greenville flights
Memphis to Savannah flights
Nashville to Greenville flights
Knoxville to Charlotte flights
Nashville to Myrtle Beach flights
Memphis to Myrtle Beach flights
Memphis to Charleston flights
Nashville to Columbia flights
Memphis to Columbia flights
Chattanooga to Savannah flights
Chattanooga to Charleston flights
Chattanooga to Myrtle Beach flights
Nashville to Hilton Head Island flights
Knoxville to Savannah flights
Memphis to Hilton Head Island flights
Blountville to Charlotte flights
Knoxville to Myrtle Beach flights
Memphis to Augusta flights
Nashville to Augusta flights
Knoxville to Columbia flights
Blountville to Myrtle Beach flights
Knoxville to Hilton Head Island flights
Chattanooga to Columbia flights
Chattanooga to Hilton Head Island flights
Memphis to Florence flights
Nashville to Florence flights

Top 2 airlines flying from Knoxville to Charleston

Discover the top 2 airlines that operate flights from Knoxville to Charleston. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated November 18, 2025.
AirlineCheapestAverageFlexibilityOn-time
American AirlinesCheapest$296Average$417FlexibilityNo cancel feeOn-time71%
DeltaCheapest$316Average$458FlexibilityNo cancel feeOn-timeN/A

100% Free

Cheapflights is completely free to use, so you can start saving the moment you arrive.

Book with Flexibility

Our users can plan ahead with confidence and find flights with no change fees

Travel Smart

Millions of people come to us for their flight needs every year. We help make travel planning easy by providing useful insights and data-driven graphs that can inform your decisions.