HomeSearch by dateVacation packagesHotelsFlight dealsCar rentalTravel tips & news
Central America

$110+ Cheap flights from Knoxville (TYS) to Central America

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 7/2. Fares are subject to change and may not be available on all flights or dates of travel.
TYS — SJO
May 28 — Jun 41
Wed 5/28
Wed 6/4
1 adult, Economy
We work with more than 300 partners to bring you better travel deals

Find cheap flights from Knoxville to Central America with Cheapflights

1. Tell us where you want to go

Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”

2. Select your favorite providers

We find the providers serving your travel needs. Choose up to four travel providers to compare side-by-side for flights, hotels, or car rentals.

3. Compare prices and book

Review each provider’s pricing and select the best option for you! Book through your favorite provider’s website for a seamless experience.

Cheap flight deals from Knoxville to Central America

Keep the following information in mind while searching for Knoxville to Central America flight deals. Data was last updated May 23, 2025.

Most accurate provider

eDreams
3 stars

Most trusted provider

eDreams
3 stars

Round-trip from

$335
(Kiwi.com)

One-way from

$110
(Mytrip)

Popular in

December

Cheapest in

February

Average price

$582
Provider with most accurate pricing for Knoxville McGhee Tyson-San Salvador El Salvador Intl flight deals.
Search Deals
Provider most trusted by Cheapflights users for Knoxville McGhee Tyson-San Salvador El Salvador Intl flights.
Search Deals
From Knoxville McGhee Tyson to Central America
Search Deals
One-way flight from Knoxville McGhee Tyson to Central America
Search Deals
Highest demand for flights based on searches. 17% potential increase in price ($137 potential increase over avg. RT price).
Search Deals
Cheapest flight prices on average. 7% potential price decrease ($48 potential savings vs. average RT price).
Search Deals
Average for round-trip flights in May 2025
Search Deals

Find flight deals from Knoxville to Central America

Cheapest flights from Knoxville to Central America
Explore the most affordable flight options available from Knoxville to Central America. Find the lowest fares from popular airlines and budget airlines, with prices last updated on May 23, 2025.

This Kiwi.com deal was found by Cheapflights users on 5/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 6/197:40 pmTYS - SJO
1 stop16h 56mMultiple Airlines
Thu 6/2611:31 amSJO - TYS
1 stop10h 02mMultiple Airlines
Deal found 5/22$335
This Mytrip deal was found by Cheapflights users on 5/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 6/159:34 pmTYS - GUA
1 stop28h 21mMultiple Airlines
Mon 6/3012:23 pmGUA - TYS
1 stop25h 45mMultiple Airlines
Deal found 5/21$356
This American Airlines deal was found by Cheapflights users on 5/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 7/68:22 pmTYS - BZE
2 stops17h 38mAmerican Airlines
Sun 7/133:25 pmBZE - TYS
2 stops19h 09mAmerican Airlines
Deal found 5/22$421
This United Airlines deal was found by Cheapflights users on 5/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 9/197:00 amTYS - PTY
1 stop12h 37mUnited Airlines
Mon 9/2210:00 amPTY - TYS
1 stop12h 44mUnited Airlines
Deal found 5/22$435
This Delta deal was found by Cheapflights users on 5/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 11/45:30 amTYS - SJO
1 stop8h 18mDelta
Wed 11/122:17 pmSJO - TYS
1 stop8h 29mDelta
Deal found 5/23$454
This American Airlines deal was found by Cheapflights users on 5/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 9/197:13 amTYS - PTY
1 stop6h 12mAmerican Airlines
Mon 9/221:50 pmPTY - TYS
2 stops19h 17mAmerican Airlines
Deal found 5/22$472
This American Airlines deal was found by Cheapflights users on 5/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 11/16:22 pmTYS - SJO
2 stops19h 43mAmerican Airlines
Sat 11/156:29 amSJO - TYS
1 stop9h 55mAmerican Airlines
Deal found 5/23$476
This Avianca deal was found by Cheapflights users on 5/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Avianca is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 11/47:10 pmTYS - SJO
2 stops13h 25mAvianca
Tue 11/184:40 pmSJO - TYS
2 stops16h 05mAvianca
Deal found 5/21$488
This American Airlines deal was found by Cheapflights users on 5/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 9/87:43 amTYS - GUA
2 stops12h 37mAmerican Airlines
Sat 10/47:20 amGUA - TYS
2 stops9h 46mAmerican Airlines
Deal found 5/22$520
This American Airlines deal was found by Cheapflights users on 5/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 9/77:51 amTYS - LIR
1 stop7h 10mAmerican Airlines
Sat 9/1312:55 pmLIR - TYS
1 stop8h 30mAmerican Airlines
Deal found 5/21$527
This Mytrip deal was found by Cheapflights users on 5/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 7/196:08 pmTYS - PTY
3 stops31h 02mMultiple Airlines
Sat 7/268:10 pmPTY - TYS
3 stops22h 54mMultiple Airlines
Deal found 5/22$530
This American Airlines deal was found by Cheapflights users on 5/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 7/15:12 pmTYS - MGA
2 stops20h 28mAmerican Airlines
Tue 7/812:38 pmMGA - TYS
2 stops21h 03mAmerican Airlines
Deal found 5/23$555

Cheapflights Fare Finder

Customize your flight search to find flights from Knoxville to Central America that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated May 23, 2025.
Use the filters below to find and compare flights from Knoxville to Central America that are best for you.

Fly from

Knoxville

Fly to

Central America

Route

Depart

Return

Price

KnoxvilleSan José

TYS - SJO

TYSSJO

Knoxville McGhee Tyson

Thu 6/19

7:40 pm-10:36 am

1 stop16h 56m

San José Juan Santamaria Intl

Thu 6/26

11:31 am-11:33 pm

1 stop10h 02m

$335

KnoxvilleGuatemala City

TYS - GUA

TYSGUA

Knoxville McGhee Tyson

Sun 6/15

9:34 pm-11:55 pm

1 stop28h 21m

Guatemala City La Aurora

Mon 6/30

12:23 pm-4:08 pm

1 stop25h 45m

$356

KnoxvilleBelize City

TYS - BZE

TYSBZE

Knoxville McGhee Tyson

Sun 7/6

8:22 pm-12:00 pm

2 stops17h 38m

Belize City Philip S.W.Goldson

Sun 7/13

3:25 pm-12:34 pm

2 stops19h 09m

$421

KnoxvillePanama City

TYS - PTY

TYSPTY

Knoxville McGhee Tyson

Fri 9/19

7:00 am-6:37 pm

1 stop12h 37m

Panama City Tocumen Intl

Mon 9/22

10:00 am-11:44 pm

1 stop12h 44m

$435

KnoxvilleSan José

TYS - SJO

TYSSJO

Knoxville McGhee Tyson

Tue 11/4

5:30 am-12:48 pm

1 stop8h 18m

San José Juan Santamaria Intl

Fri 11/14

7:00 am-6:13 pm

1 stop10h 13m

$454

KnoxvillePanama City

TYS - PTY

TYSPTY

Knoxville McGhee Tyson

Fri 9/19

7:13 am-12:25 pm

1 stop6h 12m

Panama City Tocumen Intl

Mon 9/22

1:50 pm-10:07 am

2 stops19h 17m

$472

KnoxvilleSan José

TYS - SJO

TYSSJO

Knoxville McGhee Tyson

Sat 11/1

6:22 pm-12:05 pm

2 stops19h 43m

San José Juan Santamaria Intl

Sat 11/15

6:29 am-5:24 pm

1 stop9h 55m

$476

KnoxvilleSan José

TYS - SJO

TYSSJO

Knoxville McGhee Tyson

Tue 11/4

7:10 pm-7:35 am

2 stops13h 25m

San José Juan Santamaria Intl

Tue 11/18

4:40 pm-9:45 am

2 stops16h 05m

$488

KnoxvilleGuatemala City

TYS - GUA

TYSGUA

Knoxville McGhee Tyson

Mon 9/8

7:43 am-6:20 pm

2 stops12h 37m

Guatemala City La Aurora

Sat 10/4

7:20 am-7:06 pm

2 stops9h 46m

$520

KnoxvilleLiberia

TYS - LIR

TYSLIR

Knoxville McGhee Tyson

Sun 9/7

7:51 am-1:01 pm

1 stop7h 10m

Liberia

Sat 9/13

12:55 pm-11:25 pm

1 stop8h 30m

$527

Flights are sorted by cheapest round-trip flights first.

Deals found on 5/22

Showing 1-10 of 25 results
1
2
3

Best time to book a flight from Knoxville to Central America

Have a flexible travel schedule? Discover the best time to fly to Central America from Knoxville with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Knoxville to Central America

What is the cheapest month to book a flight from Knoxville to Central America?

Currently, September is the cheapest month in which you can book a flight from Knoxville to Central America (average of $398). Flying from Knoxville to Central America in March is currently the most expensive (average of $555). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from TYS to CA?

Find hourly flight availability from Knoxville to Central America. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated May 23, 2025.

When flying from Knoxville to Central America, the time of day you decide to fly out makes little to no difference towards the overall price you’ll pay on tickets.

Rainfall in Central America by month

Plan your trip to Central America by taking into account the average rainfall totals by month.

In terms of precipitation, rainfall in Central America ranges from 0.0 - 13.0 inches per month. August is typically the wettest month, when rainfall can reach 13.0 in. February is typically the driest time to visit Central America when rainfall is around 0.0 in.

Temperature in Central America by month

Plan your trip to Central America by taking into account the average temperature totals by month.

If weather is an important factor for your trip to Central America, use this chart to help with planning. For those seeking warmer temperatures, March is the ideal time of year to visit, when temperatures reach an average of 77.0 F. Travelers looking to avoid the cold should look outside of January, when temperatures are typically at their lowest (around 73.4 F).

Reviews of airlines servicing Central America

Get insights into the airlines that provide service to Central America. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Central America. Reviews last updated May 23, 2025.
Delta
8.0
Very good
7,952 reviews

Comfort

7.9

Entertainment

7.9

Overall

8.0

Food

7.3

Boarding

8.2

Crew

8.5

Reviews

1 / 20
10.0
Excellent

Kim,May 2025

PIH - SLC

This trip was fine even with delay I had plenty of time to get connection flight!
Delta
8.0
Very good
7,952 reviews
Delta
8.0
Very good
7,952 reviews

Comfort

7.9

Entertainment

7.9

Overall

8.0

Food

7.3

Boarding

8.2

Crew

8.5

Reviews

1 / 20
10.0
Excellent

Kim,May 2025

PIH - SLC

This trip was fine even with delay I had plenty of time to get connection flight!
LATAM Airlines
7.5
Good
1,780 reviews
Delta
8.0
Very good
7,952 reviews

Comfort

7.9

Entertainment

7.9

Overall

8.0

Food

7.3

Boarding

8.2

Crew

8.5

Reviews

1 / 20
10.0
Excellent

Kim,May 2025

PIH - SLC

This trip was fine even with delay I had plenty of time to get connection flight!
United Airlines
7.4
Good
8,745 reviews
Delta
8.0
Very good
7,952 reviews

Comfort

7.9

Entertainment

7.9

Overall

8.0

Food

7.3

Boarding

8.2

Crew

8.5

Reviews

1 / 20
10.0
Excellent

Kim,May 2025

PIH - SLC

This trip was fine even with delay I had plenty of time to get connection flight!
American Airlines
7.2
Good
10,000 reviews
Delta
8.0
Very good
7,952 reviews

Comfort

7.9

Entertainment

7.9

Overall

8.0

Food

7.3

Boarding

8.2

Crew

8.5

Reviews

1 / 20
10.0
Excellent

Kim,May 2025

PIH - SLC

This trip was fine even with delay I had plenty of time to get connection flight!
Avianca
6.7
Okay
2,329 reviews
Delta
8.0
Very good
7,952 reviews

Comfort

7.9

Entertainment

7.9

Overall

8.0

Food

7.3

Boarding

8.2

Crew

8.5

Reviews

1 / 20
10.0
Excellent

Kim,May 2025

PIH - SLC

This trip was fine even with delay I had plenty of time to get connection flight!

Related info for your journey

Find useful and relevant information for your journey from Knoxville to Central America. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airport do you fly from for flights from Knoxville to Central America?

    Knoxville McGhee Tyson (TYS) is the airport you will fly out of if you book a flight from Knoxville to Central America. It is only a 11.3 mi journey to McGhee Tyson (TYS) from Knoxville’s city center.

  • What are the most popular routes from Knoxville to Central America?

    While some choose either Knoxville McGhee Tyson - Liberia or Knoxville McGhee Tyson - Guatemala City La Aurora, Knoxville McGhee Tyson - San José Juan Santamaria Intl is the most popular route from Knoxville to Central America.

  • Can I find deals for flights from Knoxville to Central America that include hotel bookings?

    Yes. In addition to deals on Knoxville to Central America flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Knoxville to Central America?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Knoxville to Central America.

  • Can I find deals for business class flights from Knoxville to Central America?

    Yes. Cheapflights offers flight deals from Knoxville to Central America by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Knoxville to Central America?

    Currently, September is the cheapest month in which you can book a flight from Knoxville to Central America (average of $398). Flying from Knoxville to Central America in March is currently the most expensive (average of $555). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Browse thousands of different options on Cheapflights for your next trip

Toggle through the tabs below to find thousands of options on Cheapflights for your next trip.

Alternative routes for Knoxville to Central America

See prices for flight routes from nearby airports that may be better suited for you.
Nashville to John F Kennedy Intl flights
Nashville to LaGuardia flights
Nashville to Seattle flights
Nashville to Newark flights
Nashville to Los Angeles flights
Nashville to Las Vegas flights
Nashville to Denver flights
Nashville to Fort Lauderdale flights
Memphis to Las Vegas flights
Nashville to Heathrow flights
Memphis to Los Angeles flights
Memphis to LaGuardia flights
Nashville to Miami flights
Nashville to Orlando flights
Memphis to Hobby flights
Nashville to Boston flights
Knoxville to Denver flights
Nashville to Sky Harbor Intl flights
Nashville to San Francisco flights
Memphis to Miami flights
Nashville to Dallas/Fort Worth flights
Memphis to Newark flights
Memphis to Orlando flights
Nashville to O'Hare Intl flights
Memphis to Dallas/Fort Worth flights
Memphis to Denver flights
Memphis to O'Hare Intl flights
Nashville to Cancún flights
Chattanooga to LaGuardia flights
Memphis to John F Kennedy Intl flights
Nashville to Portland flights
Nashville to Ontario flights
Memphis to Seattle flights
Knoxville to O'Hare Intl flights
Nashville to Hobby flights
Nashville to Reagan-National flights
Memphis to George Bush Intcntl flights
Nashville to Honolulu flights
Memphis to Atlanta flights
Nashville to Santa Ana flights
Nashville to Dulles Intl flights
Nashville to Vancouver Intl flights
Nashville to Minneapolis flights
Nashville to Raleigh flights
Chattanooga to Seattle flights
Chattanooga to John F Kennedy Intl flights
Nashville to Baltimore flights
Memphis to Dulles Intl flights
Nashville to Burbank flights
Memphis to Reagan-National flights

Top 3 airlines flying from Knoxville to Central America

Discover the top 3 airlines that operate flights from Knoxville to Central America. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated May 23, 2025.
AirlineCheapestAverageFlexibilityOn-time
DeltaCheapest$269Average$579FlexibilityNo cancel feeOn-timeN/A
American AirlinesCheapest$382Average$641FlexibilityNo cancel feeOn-time71%
United AirlinesCheapest$387Average$681FlexibilityNo cancel feeOn-time69%

100% Free

Cheapflights is completely free to use, so you can start saving the moment you arrive.

Book with Flexibility

Our users can plan ahead with confidence and find flights with no change fees

Travel Smart

Millions of people come to us for their flight needs every year. We help make travel planning easy by providing useful insights and data-driven graphs that can inform your decisions.