HomeSearch by dateVacation packagesHotelsFlight dealsCar rentalTravel tips & news
Central America

$132+ Cheap flights from Knoxville (TYS) to Central America

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 8/2. Fares are subject to change and may not be available on all flights or dates of travel.
TYS — SJO
jul. 8 — jul. 151
mar. 7/8
mar. 7/15
1 adult, Economy
We work with more than 300 partners to bring you better travel deals

Find cheap flights from Knoxville to Central America with Cheapflights

1. Tell us where you want to go

Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”

2. Select your favorite providers

We find the providers serving your travel needs. Choose up to four travel providers to compare side-by-side for flights, hotels, or car rentals.

3. Compare prices and book

Review each provider’s pricing and select the best option for you! Book through your favorite provider’s website for a seamless experience.

Cheap flight deals from Knoxville to Central America

Keep the following information in mind while searching for Knoxville to Central America flight deals. Data was last updated julio 3, 2025.

Round-trip from

$345
(Trip.com)

One-way from

$132
(Kiwi.com)

Popular in

December

Cheapest in

May

Average price

$593
From Knoxville McGhee Tyson to Central America
Search Deals
One-way flight from Knoxville McGhee Tyson to Central America
Search Deals
Highest demand for flights based on searches. 20% potential increase in price ($164 potential increase over avg. RT price).
Search Deals
Cheapest flight prices on average. 8% potential price decrease ($50 potential savings vs. average RT price).
Search Deals
Average for round-trip flights in July 2025
Search Deals

Find flight deals from Knoxville to Central America

Cheapest flights from Knoxville to Central America
Explore the most affordable flight options available from Knoxville to Central America. Find the lowest fares from popular airlines and budget airlines, with prices last updated on julio 3, 2025.

This Trip.com deal was found by Cheapflights users on 7/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Trip.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
vie. 8/156:00 amTYS - SJO
1 stop11h 13mMultiple Airlines
vie. 8/227:30 amSJO - TYS
1 stop8h 08mMultiple Airlines
Deal found 7/1$345
This American Airlines deal was found by Cheapflights users on 7/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
vie. 9/196:00 amTYS - SAL
1 stop7h 35mAmerican Airlines
sáb. 9/2712:35 pmSAL - TYS
2 stops23h 34mAmerican Airlines
Deal found 7/1$419
This Delta deal was found by Cheapflights users on 7/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
sáb. 8/95:30 amTYS - BZE
1 stop8h 14mDelta
mié. 8/1312:59 pmBZE - TYS
1 stop8h 49mDelta
Deal found 7/3$432
This American Airlines deal was found by Cheapflights users on 7/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
sáb. 8/95:30 amTYS - BZE
1 stop10h 44mAmerican Airlines
mié. 8/133:25 pmBZE - TYS
2 stops18h 05mAmerican Airlines
Deal found 7/3$436
This Trip.com deal was found by Cheapflights users on 7/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Trip.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
jue. 8/145:45 amTYS - SJO
1 stop23h 50mAvianca
jue. 8/215:10 pmSJO - TYS
1 stop15h 18mAvianca
Deal found 7/1$456
This Avianca deal was found by Cheapflights users on 7/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Avianca is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
sáb. 9/139:55 amTYS - GUA
1 stop20h 55mMultiple Airlines
sáb. 10/47:05 pmGUA - TYS
1 stop13h 24mMultiple Airlines
Deal found 7/1$491
This Delta deal was found by Cheapflights users on 7/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
lun. 8/115:45 amTYS - SJO
1 stop8h 25mDelta
dom. 8/171:35 pmSJO - TYS
1 stop8h 13mDelta
Deal found 7/3$492
This American Airlines deal was found by Cheapflights users on 7/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
mié. 10/111:07 amTYS - SJO
2 stops10h 35mAmerican Airlines
lun. 10/62:44 pmSJO - TYS
1 stop6h 51mAmerican Airlines
Deal found 7/3$496
This American Airlines deal was found by Cheapflights users on 7/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
dom. 12/76:22 pmTYS - PTY
2 stops19h 03mAmerican Airlines
sáb. 12/134:15 pmPTY - TYS
1 stop7h 05mAmerican Airlines
Deal found 7/2$512
This American Airlines deal was found by Cheapflights users on 7/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
lun. 12/16:23 pmTYS - LIR
2 stops18h 57mAmerican Airlines
jue. 3/51:50 pmLIR - TYS
2 stops19h 22mAmerican Airlines
Deal found 7/3$521
This oojo deal was found by Cheapflights users on 7/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure oojo is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
sáb. 8/305:45 amTYS - GUA
1 stop25h 05mAvianca
sáb. 9/277:05 pmGUA - TYS
1 stop13h 24mAvianca
Deal found 7/3$527
This Delta deal was found by Cheapflights users on 7/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
jue. 9/255:45 amTYS - GUA
1 stop7h 45mDelta
lun. 9/291:05 pmGUA - TYS
1 stop6h 21mDelta
Deal found 7/1$532

Cheapflights Fare Finder

Customize your flight search to find flights from Knoxville to Central America that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated julio 3, 2025.
Use the filters below to find and compare flights from Knoxville to Central America that are best for you.

Fly from

Knoxville

Fly to

Central America

Route

Depart

Return

Price

KnoxvilleSan José

TYS - SJO

TYSSJO

Knoxville McGhee Tyson

vie. 8/15

6:00 am-3:13 pm

1 stop11h 13m

San José Juan Santamaria Intl

vie. 8/22

7:30 am-5:38 pm

1 stop8h 08m

$345

KnoxvilleSan Salvador

TYS - SAL

TYSSAL

Knoxville McGhee Tyson

vie. 9/19

6:00 am-11:35 am

1 stop7h 35m

San Salvador El Salvador Intl

sáb. 9/27

12:35 pm-2:09 pm

2 stops23h 34m

$419

KnoxvilleBelize City

TYS - BZE

TYSBZE

Knoxville McGhee Tyson

sáb. 8/9

5:30 am-11:44 am

1 stop8h 14m

Belize City Philip S.W.Goldson

mié. 8/13

12:59 pm-11:48 pm

1 stop8h 49m

$432

KnoxvilleBelize City

TYS - BZE

TYSBZE

Knoxville McGhee Tyson

sáb. 8/9

5:30 am-2:14 pm

1 stop10h 44m

Belize City Philip S.W.Goldson

mié. 8/13

3:25 pm-11:30 am

2 stops18h 05m

$436

KnoxvilleSan José

TYS - SJO

TYSSJO

Knoxville McGhee Tyson

jue. 8/14

5:45 am-3:35 am

1 stop23h 50m

San José Juan Santamaria Intl

jue. 8/21

5:10 pm-10:28 am

1 stop15h 18m

$456

KnoxvilleGuatemala City

TYS - GUA

TYSGUA

Knoxville McGhee Tyson

sáb. 9/13

9:55 am-4:50 am

1 stop20h 55m

Guatemala City La Aurora

sáb. 10/4

7:05 pm-10:29 am

1 stop13h 24m

$491

KnoxvilleSan José

TYS - SJO

TYSSJO

Knoxville McGhee Tyson

lun. 8/11

5:45 am-12:10 pm

1 stop8h 25m

San José Juan Santamaria Intl

sáb. 8/16

1:35 pm-11:48 pm

1 stop8h 13m

$492

KnoxvilleSan José

TYS - SJO

TYSSJO

Knoxville McGhee Tyson

mié. 10/1

11:07 am-7:42 pm

2 stops10h 35m

San José Juan Santamaria Intl

lun. 10/6

2:44 pm-11:35 pm

1 stop6h 51m

$496

KnoxvillePanama City

TYS - PTY

TYSPTY

Knoxville McGhee Tyson

dom. 12/7

6:22 pm-1:25 pm

2 stops19h 03m

Panama City Tocumen Intl

sáb. 12/13

4:15 pm-11:20 pm

1 stop7h 05m

$512

KnoxvilleGuatemala City

TYS - GUA

TYSGUA

Knoxville McGhee Tyson

sáb. 8/30

5:45 am-4:50 am

1 stop25h 05m

Guatemala City La Aurora

sáb. 9/27

7:05 pm-10:29 am

1 stop13h 24m

$527

Flights are sorted by cheapest round-trip flights first.

Deals found on 7/3

Showing 1-10 of 37 results
1
2
3
4

Best time to book a flight from Knoxville to Central America

Have a flexible travel schedule? Discover the best time to fly to Central America from Knoxville with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Knoxville to Central America

What is the cheapest month to book a flight from Knoxville to Central America?

Currently, September is the cheapest month in which you can book a flight from Knoxville to Central America (average of $398). Flying from Knoxville to Central America in March is currently the most expensive (average of $555). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from TYS to CA?

Find hourly flight availability from Knoxville to Central America. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated julio 3, 2025.

When flying from Knoxville to Central America, the time of day you decide to fly out makes little to no difference towards the overall price you’ll pay on tickets.

Reviews of airlines servicing Central America

Get insights into the airlines that provide service to Central America. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Central America. Reviews last updated julio 3, 2025.
See what other customers who have flown with Delta, United Airlines, and American Airlines from Knoxville to Central America have to say. You can also see how each airline compares in terms of entertainment options, comfort, food, crew/service, and boarding process.
Delta
8.0
Very good
7,982 reviews

Boarding

8.2

Entertainment

7.9

Crew

8.5

Food

7.3

Overall

8.0

Comfort

7.9

Reviews

1 / 20
10.0
Excellent

Kim,May 2025

PIH - SLC

This trip was fine even with delay I had plenty of time to get connection flight!
Delta
8.0
Very good
7,982 reviews
Delta
8.0
Very good
7,982 reviews

Boarding

8.2

Entertainment

7.9

Crew

8.5

Food

7.3

Overall

8.0

Comfort

7.9

Reviews

1 / 20
10.0
Excellent

Kim,May 2025

PIH - SLC

This trip was fine even with delay I had plenty of time to get connection flight!
United Airlines
7.4
Good
8,861 reviews
Delta
8.0
Very good
7,982 reviews

Boarding

8.2

Entertainment

7.9

Crew

8.5

Food

7.3

Overall

8.0

Comfort

7.9

Reviews

1 / 20
10.0
Excellent

Kim,May 2025

PIH - SLC

This trip was fine even with delay I had plenty of time to get connection flight!
American Airlines
7.2
Good
10,000 reviews
Delta
8.0
Very good
7,982 reviews

Boarding

8.2

Entertainment

7.9

Crew

8.5

Food

7.3

Overall

8.0

Comfort

7.9

Reviews

1 / 20
10.0
Excellent

Kim,May 2025

PIH - SLC

This trip was fine even with delay I had plenty of time to get connection flight!
Avianca
6.7
Okay
2,363 reviews
Delta
8.0
Very good
7,982 reviews

Boarding

8.2

Entertainment

7.9

Crew

8.5

Food

7.3

Overall

8.0

Comfort

7.9

Reviews

1 / 20
10.0
Excellent

Kim,May 2025

PIH - SLC

This trip was fine even with delay I had plenty of time to get connection flight!

Related info for your journey

Find useful and relevant information for your journey from Knoxville to Central America. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airport do you fly from for flights from Knoxville to Central America?

    Knoxville McGhee Tyson (TYS) is the airport you will fly out of if you book a flight from Knoxville to Central America. It is only a 11.3 mi journey to McGhee Tyson (TYS) from Knoxville’s city center.

  • What are the cheapest airlines to fly from Knoxville to Central America one-way?

    To fly one-way, consider booking your trip with American Airlines, which is currently one of the cheapest options available, starting at $217. United Airlines flights start at $257 while deals on Avianca start at $311 one-way.

  • What are the most popular routes from Knoxville to Central America?

    While some choose either Knoxville McGhee Tyson - Panama City Tocumen Intl or Knoxville McGhee Tyson - San José Juan Santamaria Intl, Knoxville McGhee Tyson - Liberia is the most popular route from Knoxville to Central America.

  • Can I find deals for flights from Knoxville to Central America that include hotel bookings?

    Yes. In addition to deals on Knoxville to Central America flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Knoxville to Central America?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Knoxville to Central America.

  • Can I find deals for business class flights from Knoxville to Central America?

    Yes. Cheapflights offers flight deals from Knoxville to Central America by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Knoxville to Central America?

    Currently, September is the cheapest month in which you can book a flight from Knoxville to Central America (average of $398). Flying from Knoxville to Central America in March is currently the most expensive (average of $555). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Browse thousands of different options on Cheapflights for your next trip

Toggle through the tabs below to find thousands of options on Cheapflights for your next trip.

Alternative routes for Knoxville to Central America

See prices for flight routes from nearby airports that may be better suited for you.
Nashville to LaGuardia flights
Nashville to Seattle flights
Nashville to John F Kennedy Intl flights
Nashville to O'Hare Intl flights
Nashville to Newark flights
Nashville to Las Vegas flights
Nashville to Denver flights
Chattanooga to LaGuardia flights
Nashville to Los Angeles flights
Memphis to LaGuardia flights
Nashville to Boston flights
Memphis to Las Vegas flights
Nashville to Dallas/Fort Worth flights
Memphis to Newark flights
Nashville to Heathrow flights
Memphis to John F Kennedy Intl flights
Memphis to Los Angeles flights
Nashville to San Francisco flights
Nashville to Fort Lauderdale flights
Nashville to Orlando flights
Memphis to O'Hare Intl flights
Memphis to Denver flights
Nashville to Hobby flights
Nashville to Miami flights
Memphis to Orlando flights
Memphis to Boston flights
Memphis to Miami flights
Memphis to Minneapolis flights
Memphis to Atlanta flights
Memphis to Hobby flights
Nashville to Cancún flights
Nashville to George Bush Intcntl flights
Knoxville to Miami flights
Knoxville to LaGuardia flights
Memphis to Fort Lauderdale flights
Nashville to Portland flights
Knoxville to O'Hare Intl flights
Chattanooga to John F Kennedy Intl flights
Nashville to Salt Lake City flights
Memphis to Seattle flights
Nashville to Baltimore flights
Nashville to Haneda flights
Nashville to Tampa flights
Nashville to Honolulu flights
Nashville to Reagan-National flights
Memphis to George Bush Intcntl flights
Memphis to Philip S.W.Goldson flights
Knoxville to John F Kennedy Intl flights
Nashville to Sarasota flights
Nashville to Atlanta flights

Top 3 airlines flying from Knoxville to Central America

Discover the top 3 airlines that operate flights from Knoxville to Central America. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated julio 3, 2025.
AirlineCheapestAverageFlexibilityOn-time
DeltaCheapest$269Average$562FlexibilityNo cancel feeOn-timeN/A
American AirlinesCheapest$382Average$642FlexibilityNo cancel feeOn-time71%
United AirlinesCheapest$387Average$789FlexibilityNo cancel feeOn-time69%

100% Free

Cheapflights is completely free to use, so you can start saving the moment you arrive.

Book with Flexibility

Our users can plan ahead with confidence and find flights with no change fees

Travel Smart

Millions of people come to us for their flight needs every year. We help make travel planning easy by providing useful insights and data-driven graphs that can inform your decisions.