$178+ Cheap flights from Buffalo to Panama City, FL (BUF - ECP)
This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 6/16. Fares are subject to change and may not be available on all flights or dates of travel.
BUF — ECP
Jun 13 — Jun 201
Round-trip
1 adult, Economy
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Find cheap flights from Buffalo to Panama City with Cheapflights
1. Tell us where you want to go
Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”2. Select your favorite providers
We find the providers serving your travel needs. Choose up to four travel providers to compare side-by-side for flights, hotels, or car rentals.3. Compare prices and book
Review each provider’s pricing and select the best option for you! Book through your favorite provider’s website for a seamless experience.Cheap flight deals from Buffalo to Panama City
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Best
Last-minute
One-way
Cheapest flights from Buffalo to Panama CityExplore the most affordable flight options available from Buffalo to Panama City. Find the lowest fares from popular airlines and budget airlines, with prices last updated on May 14, 2026.
Explore the most affordable flight options available from Buffalo to Panama City. Find the lowest fares from popular airlines and budget airlines, with prices last updated on May 14, 2026.
This American Airlines deal was found by Cheapflights users on 5/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 6/236:26 am
BUF
- ECP
1 stop5h 02m
American Airlines
Tue 6/307:05 am
ECP
- BUF
1 stop4h 49m
American Airlines
Deal found 5/13![American Airlines logo]()
$355
This American Airlines deal was found by Cheapflights users on 5/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 7/146:00 am
BUF
- ECP
1 stop7h 11m
American Airlines
Sat 8/13:48 pm
ECP
- BUF
1 stop4h 36m
American Airlines
Deal found 5/13![American Airlines logo]()
$374
This American Airlines deal was found by Cheapflights users on 5/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 10/266:07 am
BUF
- ECP
2 stops7h 43m
American Airlines
Wed 11/47:10 am
ECP
- BUF
2 stops8h 43m
American Airlines
Deal found 5/14![American Airlines logo]()
$385
This American Airlines deal was found by Cheapflights users on 5/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 6/1610:44 am
BUF
- ECP
2 stops8h 42m
American Airlines
Fri 6/194:16 pm
ECP
- BUF
2 stops6h 36m
American Airlines
Deal found 5/11![American Airlines logo]()
$391
This Southwest deal was found by Cheapflights users on 5/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 6/16:00 am
BUF
- ECP
1 stop6h 35m
Southwest
Sat 6/66:35 am
ECP
- BUF
1 stop7h 15m
Southwest
Deal found 5/11![Southwest logo]()
$393
This Southwest deal was found by Cheapflights users on 5/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 6/162:55 pm
BUF
- ECP
2 stops7h 15m
Southwest
Sat 6/206:35 am
ECP
- BUF
1 stop7h 15m
Southwest
Deal found 5/11![Southwest logo]()
$396
Best flights from Buffalo to Panama CityDiscover carefully curated flight deals from Buffalo to Panama City that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated May 14, 2026.
Discover carefully curated flight deals from Buffalo to Panama City that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated May 14, 2026.
This American Airlines deal was found by Cheapflights users on 5/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 6/236:26 am
BUF
- ECP
1 stop5h 02m
American Airlines
Tue 6/307:05 am
ECP
- BUF
1 stop4h 49m
American Airlines
Deal found 5/12![American Airlines logo]()
$355
This Delta deal was found by Cheapflights users on 5/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 8/197:19 pm
BUF
- ECP
1 stop5h 11m
Delta
Mon 8/311:30 pm
ECP
- BUF
1 stop4h 13m
Delta
Deal found 5/12![Delta logo]()
$374
This Southwest deal was found by Cheapflights users on 5/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 6/16:00 am
BUF
- ECP
1 stop6h 35m
Southwest
Mon 6/81:25 pm
ECP
- BUF
2 stops9h 45m
Southwest
Deal found 5/11![Southwest logo]()
$398
This American Airlines deal was found by Cheapflights users on 5/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 7/146:00 am
BUF
- ECP
1 stop5h 27m
American Airlines
Sat 8/13:48 pm
ECP
- BUF
1 stop4h 36m
American Airlines
Deal found 5/14![American Airlines logo]()
$374
This Delta deal was found by Cheapflights users on 5/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 6/257:27 pm
BUF
- ECP
1 stop5h 17m
Delta
Mon 6/295:08 pm
ECP
- BUF
1 stop5h 51m
Delta
Deal found 5/11![Delta logo]()
$393
This Delta deal was found by Cheapflights users on 5/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 9/174:30 pm
BUF
- ECP
1 stop7h 16m
Delta
Thu 9/244:10 pm
ECP
- BUF
1 stop6h 48m
Delta
Deal found 5/11![Delta logo]()
$393
This Delta deal was found by Cheapflights users on 5/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 9/136:16 am
BUF
- ECP
1 stop5h 14m
Delta
Sat 9/197:45 am
ECP
- BUF
1 stop6h 45m
Delta
Deal found 5/9![Delta logo]()
$400
This Delta deal was found by Cheapflights users on 5/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 8/26:00 am
BUF
- ECP
1 stop5h 48m
Delta
Sun 8/96:51 pm
ECP
- BUF
1 stop4h 08m
Delta
Deal found 5/9![Delta logo]()
$407
This Delta deal was found by Cheapflights users on 5/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 6/166:00 am
BUF
- ECP
1 stop5h 54m
Delta
Sat 6/201:20 pm
ECP
- BUF
1 stop7h 07m
Delta
Deal found 5/11![Delta logo]()
$407
Last-minute flights from Buffalo to Panama CityDiscover last-minute flight deals from Buffalo to Panama City. Data last updated May 14, 2026 and is based on user searches.
Discover last-minute flight deals from Buffalo to Panama City. Data last updated May 14, 2026 and is based on user searches.
This Delta deal was found by Cheapflights users on 5/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 6/17:39 pm
BUF
- ECP
1 stop4h 49m
Delta
Mon 6/86:45 pm
ECP
- BUF
1 stop4h 14m
Delta
Deal found 5/11![Delta logo]()
$393
This Southwest deal was found by Cheapflights users on 5/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 6/111:25 am
BUF
- ECP
2 stops9h 25m
Southwest
Sat 6/68:30 am
ECP
- BUF
1 stop4h 30m
Southwest
Deal found 5/11![Southwest logo]()
$398
This Southwest deal was found by Cheapflights users on 5/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 6/111:25 am
BUF
- ECP
2 stops7h 55m
Southwest
Mon 6/81:25 pm
ECP
- BUF
2 stops9h 45m
Southwest
Deal found 5/11![Southwest logo]()
$403
This American Airlines deal was found by Cheapflights users on 5/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 6/155:00 am
BUF
- ECP
1 stop7h 04m
American Airlines
Fri 6/194:16 pm
ECP
- BUF
1 stop5h 19m
American Airlines
Deal found 5/11![American Airlines logo]()
$400
This American Airlines deal was found by Cheapflights users on 5/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 6/165:00 am
BUF
- ECP
1 stop7h 04m
American Airlines
Fri 6/194:16 pm
ECP
- BUF
1 stop5h 19m
American Airlines
Deal found 5/11![American Airlines logo]()
$381
This Southwest deal was found by Cheapflights users on 5/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 6/162:55 pm
BUF
- ECP
2 stops7h 15m
Southwest
Fri 6/197:50 am
ECP
- BUF
1 stop7h 10m
Southwest
Deal found 5/11![Southwest logo]()
$386
This Southwest deal was found by Cheapflights users on 5/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 6/162:55 pm
BUF
- ECP
2 stops7h 15m
Southwest
Sat 6/206:35 am
ECP
- BUF
1 stop7h 15m
Southwest
Deal found 5/11![Southwest logo]()
$396
This American Airlines deal was found by Cheapflights users on 5/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 6/236:26 am
BUF
- ECP
1 stop5h 02m
American Airlines
Tue 6/307:05 am
ECP
- BUF
1 stop4h 49m
American Airlines
Deal found 5/13![American Airlines logo]()
$355
One-way flights from Buffalo to Panama CitySearch for one-way flight options from Buffalo to Panama City. Find affordable one-way fares based on user searches. Data last updated May 14, 2026.
Search for one-way flight options from Buffalo to Panama City. Find affordable one-way fares based on user searches. Data last updated May 14, 2026.
This Delta deal was found by Cheapflights users on 5/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 6/166:00 am
BUF
- ECP
1 stop5h 54m
Delta
Deal found 5/12![Delta logo]()
$178
This American Airlines deal was found by Cheapflights users on 5/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 6/162:47 pm
BUF
- ECP
2 stops9h 53m
American Airlines
Deal found 5/13![American Airlines logo]()
$183
This Delta deal was found by Cheapflights users on 5/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 7/46:10 am
BUF
- ECP
1 stop7h 27m
Delta
Deal found 5/10![Delta logo]()
$197
This American Airlines deal was found by Cheapflights users on 5/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 6/215:33 am
BUF
- ECP
1 stop7h 36m
American Airlines
Deal found 5/11![American Airlines logo]()
$214
This American Airlines deal was found by Cheapflights users on 5/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 7/76:00 am
BUF
- ECP
2 stops10h 47m
American Airlines
Deal found 5/10![American Airlines logo]()
$223
This American Airlines deal was found by Cheapflights users on 5/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 7/36:00 am
BUF
- ECP
1 stop5h 26m
American Airlines
Deal found 5/10![American Airlines logo]()
$243
This American Airlines deal was found by Cheapflights users on 5/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 7/96:00 am
BUF
- ECP
1 stop6h 25m
American Airlines
Deal found 5/10![American Airlines logo]()
$253
This Delta deal was found by Cheapflights users on 5/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 7/36:03 am
BUF
- ECP
2 stops16h 56m
Delta
Deal found 5/10![Delta logo]()
$258
This Southwest deal was found by Cheapflights users on 5/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 6/216:10 am
BUF
- ECP
2 stops8h 20m
Southwest
Deal found 5/11![Southwest logo]()
$270
This Delta deal was found by Cheapflights users on 5/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 7/98:05 pm
BUF
- ECP
2 stops15h 43m
Delta
Deal found 5/10![Delta logo]()
$288
This American Airlines deal was found by Cheapflights users on 5/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 7/512:33 pm
BUF
- ECP
2 stops12h 04m
American Airlines
Deal found 5/10![American Airlines logo]()
$334
Find flight deals from Buffalo to Panama City
Discover tips and strategies to find the most affordable flight options for your journey from Buffalo (BUF) to Panama City (ECP). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated May 14, 2026.
Most accurate provider | FlightHub 3 stars |
|---|---|
Most trusted provider | FlightHub 3 stars |
Round-trip from | $355 (Delta) |
One-way from | $178 (Delta) |
Popular in | April |
Cheapest in | November |
Average price | $492 |
Cheapflights Fare Finder
Customize your flight search to find flights from Buffalo to Panama City that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated May 14, 2026.
Use the filters below to find and compare flights from Buffalo to Panama City that are best for you.
Fly from
Fly to
Route
Depart
Return
Cheapest round-trip
BuffaloPanama City
BUF - ECP
BUFECP
Buffalo
Tue 6/23
6:26 am-10:28 am
1 stop5h 02m
Panama City NW Florida Beaches
Tue 6/30
7:05 am-12:54 pm
1 stop4h 49m
$355
Quickest round-trip
BuffaloPanama City
BUF - ECP
BUFECP
Buffalo
Wed 8/19
7:19 pm-11:30 pm
1 stop5h 11m
Panama City NW Florida Beaches
Mon 8/31
1:30 pm-6:43 pm
1 stop4h 13m
$374
BuffaloPanama City
BUF - ECP
BUFECP
Buffalo
Tue 7/14
6:00 am-10:27 am
1 stop5h 27m
Panama City NW Florida Beaches
Sat 8/1
3:48 pm-9:24 pm
1 stop4h 36m
$374
BuffaloPanama City
BUF - ECP
BUFECP
Buffalo
Thu 6/25
7:27 pm-11:44 pm
1 stop5h 17m
Panama City NW Florida Beaches
Mon 6/29
5:08 pm-11:59 pm
1 stop5h 51m
$393
BuffaloPanama City
BUF - ECP
BUFECP
Buffalo
Thu 9/17
4:30 pm-10:46 pm
1 stop7h 16m
Panama City NW Florida Beaches
Thu 9/24
4:10 pm-11:58 pm
1 stop6h 48m
$393
BuffaloPanama City
BUF - ECP
BUFECP
Buffalo
Mon 6/1
6:00 am-11:35 am
1 stop6h 35m
Panama City NW Florida Beaches
Mon 6/8
1:25 pm-12:10 am
2 stops9h 45m
$398
BuffaloPanama City
BUF - ECP
BUFECP
Buffalo
Sun 9/13
6:16 am-10:30 am
1 stop5h 14m
Panama City NW Florida Beaches
Sat 9/19
7:45 am-3:30 pm
1 stop6h 45m
$400
BuffaloPanama City
BUF - ECP
BUFECP
Buffalo
Sun 8/2
6:00 am-10:48 am
1 stop5h 48m
Panama City NW Florida Beaches
Sun 8/9
6:51 pm-11:59 pm
1 stop4h 08m
$407
BuffaloPanama City
BUF - ECP
BUFECP
Buffalo
Tue 6/16
6:00 am-10:54 am
1 stop5h 54m
Panama City NW Florida Beaches
Sat 6/20
1:20 pm-9:27 pm
1 stop7h 07m
$407
Cheapest one-way
BuffaloPanama City
BUF - ECP
BUFECP
Buffalo
Wed 7/8
6:00 am-10:48 am
1 stop5h 48m
$178
Showing 1-10 of 15 resultsSorted by cheapest first
Compare providers for flights from Buffalo to Panama City
Provider information is updated monthly. Please note that these providers often have deals for this flight, but the availability may vary on a day-by-day basis on Cheapflights.
Use the table below to compare price accuracy, trust ratings, and cancellation policies for each provider offering flight deals from Buffalo to Panama City in May.
| Provider | Price Accuracy | Trust Score* |
|---|---|---|
| Price Accuracy1 star | Trust Score*3 stars | |
| Price Accuracy3 stars | Trust Score*3 stars |
- Most accurate provider: When it comes to deals on Buffalo-Panama City, Florida flights, users find the pricing of FlightHub to be most consistent on Cheapflights vs. FlightHub Users can find the same prices on Buffalo-Panama City, Florida flight deals on Cheapflights vs. FlightHub >95% of the time. Price accuracy is based on data collected from Buffalo-Panama City, Florida flight searches over the past month and is updated monthly.
- Most trusted provider: When it comes to deals on Buffalo-Panama City, Florida flights, Cheapflights users trust FlightHub the most. FlightHub has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for Buffalo-Panama City, Florida flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.
Best time to book a flight from Buffalo to Panama City
Have a flexible travel schedule? Discover the best time to fly to Panama City from Buffalo with our price prediction graph.
BUF-ECP
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.
Cheapflights Insights
Everything you need to know about your flight from Buffalo to Panama City
What is the cheapest month to book a flight from Buffalo to Panama City, Florida?
Currently, November is the cheapest month in which you can book a flight from Buffalo to Panama City, Florida (average of $349). Flying from Buffalo to Panama City, Florida in April is currently the most expensive (average of $637). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.
How much does it cost to fly round-trip from Buffalo to Panama City, Florida?
Reviews of airlines servicing Panama City
Get insights into the airlines that provide service to Panama City. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Panama City. Reviews last updated May 14, 2026.
Get a feel of what it's like to fly with Southwest,Delta, andAmerican Airlines from Buffalo to Panama City by reading reviews from past customers. Users have also rated airlines in terms of entertainment options, comfort, food, crew/service, and boarding process.
Crew
8.6
Entertainment
7.5
Food
7.0
Boarding
8.1
Comfort
8.0
Overall
8.0
Reviews
1 / 20
2.0
MediocreDominic,Mar 2026
MCO - SMF
Crew
8.6
Entertainment
7.5
Food
7.0
Boarding
8.1
Comfort
8.0
Overall
8.0
Reviews
1 / 20
2.0
MediocreDominic,Mar 2026
MCO - SMF
Crew
8.6
Entertainment
7.5
Food
7.0
Boarding
8.1
Comfort
8.0
Overall
8.0
Reviews
1 / 20
2.0
MediocreDominic,Mar 2026
MCO - SMF
Crew
8.6
Entertainment
7.5
Food
7.0
Boarding
8.1
Comfort
8.0
Overall
8.0
Reviews
1 / 20
2.0
MediocreDominic,Mar 2026
MCO - SMF
Related info for your journey
Find useful and relevant information for your journey from Buffalo to Panama City. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.
Traveling to a place near Panama City?
Book flights to Panama City if you plan to visit one of these locationsMexico Beach
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Buffalo and Panama City flights
Browse other Buffalo and Panama City flight options. Last updated on May 14, 2026.
Other flights from Buffalo
Browse through other flights departing from Buffalo. Flights are based on user searches made on Cheapflights and were last updated on May 14, 2026.
Other flights to Panama City
Explore flights to Panama City departing from other origins. Flights are based on user searches made on Cheapflights and were last updated on May 14, 2026.
Popular flight searches
Check out other popular destinations found by fellow travelers in 2026
Top 3 airlines flying from Buffalo to Panama City
Discover the top 3 airlines that operate flights from Buffalo to Panama City. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated May 14, 2026.
| Airline | Cheapest | Average | Flexibility | On-time |
|---|---|---|---|---|
| Cheapest$222 | Average$425 | FlexibilityNo cancel fee | On-timeN/A | |
| Cheapest$286 | Average$487 | FlexibilityNo cancel fee | On-time71% | |
| Cheapest$381 | Average$520 | FlexibilityNo cancel fee | On-time63% |