$159+ Cheap flights from Panama City, FL to Buffalo (ECP - BUF)
This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 8/19. Fares are subject to change and may not be available on all flights or dates of travel.
ECP — BUF
Jul 17 — Jul 241
Round-trip
1 adult, Economy
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Find cheap flights from Panama City to Buffalo with Cheapflights
1. Tell us where you want to go
Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”2. Select your favorite providers
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Review each provider’s pricing and select the best option for you! Book through your favorite provider’s website for a seamless experience.Cheap flight deals from Panama City to Buffalo
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Best
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Cheapest flights from Panama City to BuffaloExplore the most affordable flight options available from Panama City to Buffalo. Find the lowest fares from popular airlines and budget airlines, with prices last updated on June 17, 2026.
Explore the most affordable flight options available from Panama City to Buffalo. Find the lowest fares from popular airlines and budget airlines, with prices last updated on June 17, 2026.
This Delta deal was found by Cheapflights users on 6/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 8/266:00 am
ECP
- BUF
1 stop4h 08m
Delta
Tue 9/16:05 am
BUF
- ECP
1 stop5h 37m
Delta
Deal found 6/16![Delta logo]()
$317
This Delta deal was found by Cheapflights users on 6/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 8/266:00 am
ECP
- BUF
1 stop4h 08m
Delta
Mon 8/316:05 am
BUF
- ECP
1 stop5h 37m
Delta
Deal found 6/16![Delta logo]()
$329
This Southwest deal was found by Cheapflights users on 6/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 9/1511:30 am
ECP
- BUF
2 stops9h 15m
Southwest
Sat 9/195:45 am
BUF
- ECP
1 stop9h 10m
Southwest
Deal found 6/16![Southwest logo]()
$340
This Delta deal was found by Cheapflights users on 6/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 8/276:51 pm
ECP
- BUF
1 stop4h 08m
Delta
Mon 8/316:05 am
BUF
- ECP
1 stop5h 37m
Delta
Deal found 6/16![Delta logo]()
$341
This American Airlines deal was found by Cheapflights users on 6/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 8/141:15 pm
ECP
- BUF
1 stop4h 52m
American Airlines
Tue 8/1812:56 pm
BUF
- ECP
1 stop5h 20m
American Airlines
Deal found 6/16![American Airlines logo]()
$362
This Southwest deal was found by Cheapflights users on 6/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 8/141:30 pm
ECP
- BUF
2 stops7h 20m
Southwest
Tue 8/188:05 am
BUF
- ECP
2 stops7h 55m
Southwest
Deal found 6/16![Southwest logo]()
$372
This United Airlines deal was found by Cheapflights users on 6/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 8/271:47 pm
ECP
- BUF
1 stop6h 20m
United Airlines
Mon 8/316:55 am
BUF
- ECP
2 stops10h 43m
United Airlines
Deal found 6/16![United Airlines logo]()
$374
This Southwest deal was found by Cheapflights users on 6/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/162:20 pm
ECP
- BUF
2 stops8h 50m
Southwest
Mon 10/192:50 pm
BUF
- ECP
1 stop6h 45m
Southwest
Deal found 6/16![Southwest logo]()
$379
This Southwest deal was found by Cheapflights users on 6/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 8/271:30 pm
ECP
- BUF
2 stops7h 20m
Southwest
Mon 8/315:40 am
BUF
- ECP
2 stops8h 25m
Southwest
Deal found 6/16![Southwest logo]()
$384
Best flights from Panama City to BuffaloDiscover carefully curated flight deals from Panama City to Buffalo that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated June 17, 2026.
Discover carefully curated flight deals from Panama City to Buffalo that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated June 17, 2026.
This Delta deal was found by Cheapflights users on 6/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 8/276:51 pm
ECP
- BUF
1 stop4h 08m
Delta
Mon 8/316:05 am
BUF
- ECP
1 stop5h 37m
Delta
Deal found 6/13![Delta logo]()
$341
This Southwest deal was found by Cheapflights users on 6/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 6/307:40 am
ECP
- BUF
1 stop5h 40m
Southwest
Sat 7/48:45 am
BUF
- ECP
1 stop8h 15m
Southwest
Deal found 6/15![Southwest logo]()
$401
This American Airlines deal was found by Cheapflights users on 6/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 7/234:17 pm
ECP
- BUF
1 stop5h 34m
American Airlines
Sun 7/265:24 am
BUF
- ECP
1 stop7h 40m
American Airlines
Deal found 6/15![American Airlines logo]()
$407
This United Airlines deal was found by Cheapflights users on 6/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 9/11:47 pm
ECP
- BUF
1 stop6h 20m
United Airlines
Wed 9/26:55 am
BUF
- ECP
1 stop7h 11m
United Airlines
Deal found 6/12![United Airlines logo]()
$437
This Delta deal was found by Cheapflights users on 6/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/167:45 am
ECP
- BUF
1 stop6h 42m
Delta
Mon 10/196:16 am
BUF
- ECP
1 stop7h 15m
Delta
Deal found 6/16![Delta logo]()
$374
This Delta deal was found by Cheapflights users on 6/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 7/2911:38 am
ECP
- BUF
1 stop6h 03m
Delta
Sat 8/155:13 pm
BUF
- ECP
1 stop5h 27m
Delta
Deal found 6/16![Delta logo]()
$398
This Southwest deal was found by Cheapflights users on 6/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 7/316:55 am
ECP
- BUF
2 stops8h 05m
Southwest
Sat 8/157:50 am
BUF
- ECP
2 stops7h 15m
Southwest
Deal found 6/16![Southwest logo]()
$443
Last-minute flights from Panama City to BuffaloDiscover last-minute flight deals from Panama City to Buffalo. Data last updated June 17, 2026 and is based on user searches.
Discover last-minute flight deals from Panama City to Buffalo. Data last updated June 17, 2026 and is based on user searches.
This Southwest deal was found by Cheapflights users on 6/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 6/307:40 am
ECP
- BUF
1 stop5h 40m
Southwest
Sat 7/48:45 am
BUF
- ECP
2 stops7h 10m
Southwest
Deal found 6/15![Southwest logo]()
$400
This American Airlines deal was found by Cheapflights users on 6/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 7/234:17 pm
ECP
- BUF
1 stop5h 34m
American Airlines
Sun 7/265:24 am
BUF
- ECP
1 stop7h 40m
American Airlines
Deal found 6/16![American Airlines logo]()
$407
This Delta deal was found by Cheapflights users on 6/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 7/281:36 pm
ECP
- BUF
1 stop4h 05m
Delta
Sat 8/155:13 pm
BUF
- ECP
1 stop5h 27m
Delta
Deal found 6/16![Delta logo]()
$398
This American Airlines deal was found by Cheapflights users on 6/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 7/2811:00 am
ECP
- BUF
2 stops9h 07m
American Airlines
Sat 8/151:03 pm
BUF
- ECP
2 stops10h 37m
American Airlines
Deal found 6/16![American Airlines logo]()
$517
This Delta deal was found by Cheapflights users on 6/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 7/306:48 pm
ECP
- BUF
1 stop4h 11m
Delta
Sat 8/155:13 pm
BUF
- ECP
1 stop5h 27m
Delta
Deal found 6/16![Delta logo]()
$443
This American Airlines deal was found by Cheapflights users on 6/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 7/314:17 pm
ECP
- BUF
1 stop5h 34m
American Airlines
Sat 8/156:59 pm
BUF
- ECP
1 stop4h 41m
American Airlines
Deal found 6/16![American Airlines logo]()
$374
One-way flights from Panama City to BuffaloSearch for one-way flight options from Panama City to Buffalo. Find affordable one-way fares based on user searches. Data last updated June 17, 2026.
Search for one-way flight options from Panama City to Buffalo. Find affordable one-way fares based on user searches. Data last updated June 17, 2026.
This Delta deal was found by Cheapflights users on 6/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 8/197:35 am
ECP
- BUF
1 stop6h 31m
Delta
Deal found 6/16![Delta logo]()
$159
This Southwest deal was found by Cheapflights users on 6/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 8/1911:30 am
ECP
- BUF
2 stops9h 15m
Southwest
Deal found 6/16![Southwest logo]()
$164
This Southwest deal was found by Cheapflights users on 6/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 8/2611:30 am
ECP
- BUF
2 stops9h 10m
Southwest
Deal found 6/14![Southwest logo]()
$176
This American Airlines deal was found by Cheapflights users on 6/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 7/34:17 pm
ECP
- BUF
1 stop6h 02m
American Airlines
Deal found 6/14![American Airlines logo]()
$178
This Delta deal was found by Cheapflights users on 6/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 7/75:03 pm
ECP
- BUF
1 stop5h 56m
Delta
Deal found 6/16![Delta logo]()
$190
This Southwest deal was found by Cheapflights users on 6/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 7/72:25 pm
ECP
- BUF
2 stops7h 20m
Southwest
Deal found 6/16![Southwest logo]()
$195
This Southwest deal was found by Cheapflights users on 6/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 7/312:00 pm
ECP
- BUF
2 stops9h 35m
Southwest
Deal found 6/14![Southwest logo]()
$215
This American Airlines deal was found by Cheapflights users on 6/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 7/87:05 am
ECP
- BUF
1 stop5h 00m
American Airlines
Deal found 6/16![American Airlines logo]()
$254
This Delta deal was found by Cheapflights users on 6/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 7/66:45 pm
ECP
- BUF
1 stop4h 14m
Delta
Deal found 6/16![Delta logo]()
$280
This American Airlines deal was found by Cheapflights users on 6/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 7/611:00 am
ECP
- BUF
2 stops9h 55m
American Airlines
Deal found 6/16![American Airlines logo]()
$403
This United Airlines deal was found by Cheapflights users on 6/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 7/62:05 pm
ECP
- BUF
3 stops31h 26m
United Airlines
Deal found 6/16![United Airlines logo]()
$498
Find flight deals from Panama City to Buffalo
Discover tips and strategies to find the most affordable flight options for your journey from Panama City (ECP) to Buffalo (BUF). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated June 17, 2026.
Most accurate provider | FlightHub 3 stars |
|---|---|
Most trusted provider | FlightHub 3 stars |
Round-trip from | $317 (Delta) |
One-way from | $159 (American Airlines) |
Cheapflights Fare Finder
Customize your flight search to find flights from Panama City to Buffalo that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated June 17, 2026.
Use the filters below to find and compare flights from Panama City to Buffalo that are best for you.
Fly from
Fly to
Route
Depart
Return
Cheapest round-trip
Quickest round-trip
Panama CityBuffalo
ECP - BUF
ECPBUF
Panama City NW Florida Beaches
Thu 8/27
6:51 pm-11:59 pm
1 stop4h 08m
Buffalo
Mon 8/31
6:05 am-10:42 am
1 stop5h 37m
$341
Panama CityBuffalo
ECP - BUF
ECPBUF
Panama City NW Florida Beaches
Fri 10/16
7:45 am-3:27 pm
1 stop6h 42m
Buffalo
Mon 10/19
6:16 am-12:31 pm
1 stop7h 15m
$374
Panama CityBuffalo
ECP - BUF
ECPBUF
Panama City NW Florida Beaches
Wed 7/29
11:38 am-6:41 pm
1 stop6h 03m
Buffalo
Sat 8/15
5:13 pm-9:40 pm
1 stop5h 27m
$398
Panama CityBuffalo
ECP - BUF
ECPBUF
Panama City NW Florida Beaches
Tue 6/30
7:40 am-2:20 pm
1 stop5h 40m
Buffalo
Sat 7/4
8:45 am-4:00 pm
1 stop8h 15m
$401
Panama CityBuffalo
ECP - BUF
ECPBUF
Panama City NW Florida Beaches
Thu 7/23
4:17 pm-10:51 pm
1 stop5h 34m
Buffalo
Sun 7/26
5:24 am-12:04 pm
1 stop7h 40m
$407
Panama CityBuffalo
ECP - BUF
ECPBUF
Panama City NW Florida Beaches
Tue 9/1
1:47 pm-9:07 pm
1 stop6h 20m
Buffalo
Wed 9/2
6:55 am-1:06 pm
1 stop7h 11m
$437
Panama CityBuffalo
ECP - BUF
ECPBUF
Panama City NW Florida Beaches
Fri 7/31
6:55 am-4:00 pm
2 stops8h 05m
Buffalo
Sat 8/15
7:50 am-2:05 pm
2 stops7h 15m
$443
Cheapest one-way
Quickest one-way
Panama CityBuffalo
ECP - BUF
ECPBUF
Panama City NW Florida Beaches
Wed 9/2
6:00 am-11:08 am
1 stop4h 08m
$159
Panama CityBuffalo
ECP - BUF
ECPBUF
Panama City NW Florida Beaches
Wed 9/2
11:30 am-9:05 pm
2 stops8h 35m
$176
Panama CityBuffalo
ECP - BUF
ECPBUF
Panama City NW Florida Beaches
Wed 8/26
11:30 am-9:40 pm
2 stops9h 10m
$176
Showing 1-10 of 19 resultsSorted by cheapest first
Compare providers for flights from Panama City to Buffalo
Provider information is updated monthly. Please note that these providers often have deals for this flight, but the availability may vary on a day-by-day basis on Cheapflights.
Use the table below to compare price accuracy, trust ratings, and cancellation policies for each provider offering flight deals from Panama City to Buffalo in June.
| Provider | Price Accuracy | Trust Score* |
|---|---|---|
| Price Accuracy1 star | Trust Score*3 stars | |
| Price Accuracy3 stars | Trust Score*3 stars |
- Most accurate provider: When it comes to deals on Panama City, Florida-Buffalo flights, users find the pricing of FlightHub to be most consistent on Cheapflights vs. FlightHub Users can find the same prices on Panama City, Florida-Buffalo flight deals on Cheapflights vs. FlightHub >95% of the time. Price accuracy is based on data collected from Panama City, Florida-Buffalo flight searches over the past month and is updated monthly.
- Most trusted provider: When it comes to deals on Panama City, Florida-Buffalo flights, Cheapflights users trust FlightHub the most. FlightHub has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for Panama City, Florida-Buffalo flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.
Best time to book a flight from Panama City to Buffalo
Have a flexible travel schedule? Discover the best time to fly to Buffalo from Panama City with our price prediction graph.
ECP-BUF
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.
Reviews of airlines servicing Buffalo
Get insights into the airlines that provide service to Buffalo. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Buffalo. Reviews last updated June 17, 2026.
Read reviews from past customers who have flown American Airlines from Panama City to Buffalo. Users can see the overall rating for each airline as well as how each is rated in terms of entertainment options, comfort, food, crew/service, and boarding process.
Comfort
7.2
Entertainment
6.8
Food
6.4
Boarding
7.5
Overall
7.1
Crew
7.9
Reviews
1 / 20
2.0
MediocreAnonymous,Mar 2026
MIA - SFO
Comfort
7.2
Entertainment
6.8
Food
6.4
Boarding
7.5
Overall
7.1
Crew
7.9
Reviews
1 / 20
2.0
MediocreAnonymous,Mar 2026
MIA - SFO
Related info for your journey
Find useful and relevant information for your journey from Panama City to Buffalo. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.
Traveling to a place near Buffalo?
Book flights to Buffalo if you plan to visit one of these locationsLockport
Cheektowaga
Amherst
Batavia
Williamsville
Orchard Park
Eden
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Other flights to Buffalo
Explore flights to Buffalo departing from other origins. Flights are based on user searches made on Cheapflights and were last updated on June 17, 2026.
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Panama City and Buffalo flights
Browse other Panama City and Buffalo flight options. Last updated on June 17, 2026.
Other flights from Panama City
Browse through other flights departing from Panama City. Flights are based on user searches made on Cheapflights and were last updated on June 17, 2026.
Popular flight searches
Check out other popular destinations found by fellow travelers in 2026
Top airline flying from Panama City to Buffalo
Discover the top airline that operate flights from Panama City to Buffalo. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated June 17, 2026.
| Airline | Cheapest | Average | Flexibility | On-time |
|---|---|---|---|---|
| Cheapest$236 | Average$412 | FlexibilityNo cancel fee | On-time71% |