$178+ Cheap flights from Panama City, FL to Buffalo (ECP - BUF)
This is the cheapest round-trip flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 12/24. Fares are subject to change and may not be available on all flights or dates of travel.
ECP — BUF
Nov 29 — Dec 61
Round-trip
1 adult, Economy
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Find cheap flights from Panama City to Buffalo with Cheapflights
1. Tell us where you want to go
Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”2. Select your favorite providers
We find the providers serving your travel needs. Choose up to four travel providers to compare side-by-side for flights, hotels, or car rentals.3. Compare prices and book
Review each provider’s pricing and select the best option for you! Book through your favorite provider’s website for a seamless experience.Cheap flight deals from Panama City to Buffalo
Cheapest
Best
Last-minute
One-way
Cheapest flights from Panama City to BuffaloExplore the most affordable flight options available from Panama City to Buffalo. Find the lowest fares from popular airlines and budget airlines, with prices last updated on October 30, 2026.
Explore the most affordable flight options available from Panama City to Buffalo. Find the lowest fares from popular airlines and budget airlines, with prices last updated on October 30, 2026.
This United Airlines deal was found by Cheapflights users on 10/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 12/81:58 pm -
1 stop5h 58m
Tue 12/156:30 am -
1 stop7h 47m
Deal found 10/29![United Airlines logo]()
$295
This Southwest deal was found by Cheapflights users on 10/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 12/87:55 am -
1 stop6h 20m
Tue 12/1512:45 pm -
2 stops6h 30m
Deal found 10/29![Southwest logo]()
$300
This Southwest deal was found by Cheapflights users on 10/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 11/147:50 am -
1 stop7h 10m
Sat 11/2112:35 pm -
2 stops10h 00m
Deal found 10/29![Southwest logo]()
$443
This American Airlines deal was found by Cheapflights users on 10/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/2411:45 am -
1 stop6h 05m
Mon 12/287:47 pm -
1 stop4h 53m
Deal found 10/28![American Airlines logo]()
$641
This United Airlines deal was found by Cheapflights users on 10/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 11/109:06 am -
2 stops12h 53m
Wed 11/116:00 am -
2 stops11h 18m
Deal found 10/27![United Airlines logo]()
$698
This American Airlines deal was found by Cheapflights users on 10/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/3112:01 pm -
1 stop4h 55m
Sat 11/712:58 pm -
1 stop5h 29m
Deal found 10/30![American Airlines logo]()
$701
This American Airlines deal was found by Cheapflights users on 10/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/3111:04 am -
2 stops9h 25m
Wed 11/47:03 am -
1 stop5h 27m
Deal found 10/30![American Airlines logo]()
$706
This Delta deal was found by Cheapflights users on 10/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 11/36:00 am -
1 stop4h 16m
Tue 11/35:20 pm -
1 stop6h 58m
Deal found 10/30![Delta logo]()
$731
Best flights from Panama City to BuffaloDiscover carefully curated flight deals from Panama City to Buffalo that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated October 30, 2026.
Discover carefully curated flight deals from Panama City to Buffalo that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated October 30, 2026.
This United Airlines deal was found by Cheapflights users on 10/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 12/81:58 pm -
1 stop5h 58m
Tue 12/156:30 am -
1 stop7h 47m
Deal found 10/29![United Airlines logo]()
$295
This Southwest deal was found by Cheapflights users on 10/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 12/87:55 am -
1 stop6h 20m
Tue 12/1512:45 pm -
2 stops6h 30m
Deal found 10/29![Southwest logo]()
$300
This American Airlines deal was found by Cheapflights users on 10/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/2411:45 am -
1 stop6h 05m
Mon 12/287:47 pm -
1 stop4h 53m
Deal found 10/28![American Airlines logo]()
$641
This Southwest deal was found by Cheapflights users on 10/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 11/147:50 am -
1 stop7h 10m
Sat 11/2112:35 pm -
2 stops10h 00m
Deal found 10/29![Southwest logo]()
$443
This United Airlines deal was found by Cheapflights users on 10/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 11/109:06 am -
2 stops12h 53m
Wed 11/116:00 am -
2 stops11h 18m
Deal found 10/27![United Airlines logo]()
$698
Last-minute flights from Panama City to BuffaloDiscover last-minute flight deals from Panama City to Buffalo. Data last updated October 30, 2026 and is based on user searches.
Discover last-minute flight deals from Panama City to Buffalo. Data last updated October 30, 2026 and is based on user searches.
This American Airlines deal was found by Cheapflights users on 10/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/3112:01 pm -
1 stop4h 55m
Sat 11/712:58 pm -
1 stop5h 29m
Deal found 10/30![American Airlines logo]()
$701
This American Airlines deal was found by Cheapflights users on 10/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/3111:04 am -
2 stops9h 25m
Wed 11/47:03 am -
1 stop5h 27m
Deal found 10/30![American Airlines logo]()
$706
This American Airlines deal was found by Cheapflights users on 10/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/3112:01 pm -
1 stop4h 55m
Fri 11/67:37 pm -
1 stop5h 11m
Deal found 10/30![American Airlines logo]()
$764
This American Airlines deal was found by Cheapflights users on 10/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/3112:01 pm -
1 stop4h 55m
Sun 11/84:16 pm -
2 stops8h 32m
Deal found 10/30![American Airlines logo]()
$769
This American Airlines deal was found by Cheapflights users on 10/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 11/212:00 pm -
1 stop5h 08m
Wed 11/47:03 am -
1 stop5h 27m
Deal found 10/30![American Airlines logo]()
$781
This Delta deal was found by Cheapflights users on 10/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 11/36:00 am -
1 stop4h 16m
Tue 11/35:20 pm -
1 stop6h 58m
Deal found 10/30![Delta logo]()
$731
This American Airlines deal was found by Cheapflights users on 10/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 11/31:33 pm -
2 stops8h 00m
Mon 11/95:40 am -
2 stops8h 23m
Deal found 10/30![American Airlines logo]()
$774
This United Airlines deal was found by Cheapflights users on 10/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 11/109:06 am -
2 stops12h 53m
Wed 11/116:00 am -
2 stops11h 18m
Deal found 10/27![United Airlines logo]()
$698
This Southwest deal was found by Cheapflights users on 10/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 11/147:50 am -
1 stop7h 10m
Sat 11/2112:35 pm -
2 stops10h 00m
Deal found 10/29![Southwest logo]()
$443
One-way flights from Panama City to BuffaloSearch for one-way flight options from Panama City to Buffalo. Find affordable one-way fares based on user searches. Data last updated October 30, 2026.
Search for one-way flight options from Panama City to Buffalo. Find affordable one-way fares based on user searches. Data last updated October 30, 2026.
This American Airlines deal was found by Cheapflights users on 10/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/2411:45 am -
1 stop6h 05m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 10/28![American Airlines logo]()
$178
This Southwest deal was found by Cheapflights users on 10/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/247:30 am -
2 stops13h 30m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 10/28![Southwest logo]()
$189
This Delta deal was found by Cheapflights users on 10/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/236:00 am -
1 stop4h 10m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 10/28![Delta logo]()
$220
This Delta deal was found by Cheapflights users on 10/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 3/206:00 am -
1 stop4h 15m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 10/29![Delta logo]()
$238
This Delta deal was found by Cheapflights users on 10/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 11/276:00 am -
1 stop4h 06m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 10/30![Delta logo]()
$270
This Southwest deal was found by Cheapflights users on 10/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 3/201:30 pm -
2 stops6h 45m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 10/29![Southwest logo]()
$325
This American Airlines deal was found by Cheapflights users on 10/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/237:36 am -
2 stops9h 01m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 10/28![American Airlines logo]()
$335
This Southwest deal was found by Cheapflights users on 10/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 11/277:55 am -
2 stops9h 40m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 10/30![Southwest logo]()
$364
This United Airlines deal was found by Cheapflights users on 10/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 11/279:06 am -
3 stops34h 45m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 10/30![United Airlines logo]()
$944
Find flight deals from Panama City to Buffalo
Discover tips and strategies to find the most affordable flight options for your journey from Panama City (ECP) to Buffalo (BUF). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated October 30, 2026.
Most accurate provider | FlightHub 3 stars |
|---|---|
Most trusted provider | FlightHub 3 stars |
Round-trip from | $295 (United Airlines) |
One-way from | $178 (American Airlines) |
Cheapflights Fare Finder
Customize your flight search to find flights from Panama City to Buffalo that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 7,457,451 searches. Data last updated October 30, 2026.
Use the filters below to find and compare flights from Panama City to Buffalo that are best for you.
Fly from
Fly to
Route
Depart
Return
Cheapest round-trip
Panama CityBuffalo
ECP Panama City NW Florida Beaches - BUF Buffalo
ECPBUF
Panama City NW Florida Beaches
Thu 12/24
11:45 am-6:50 pm
1 stop6h 05m
Buffalo
Wed 12/31
12:00 am-11:00 pm
Nonstop0h 00m
$178
Panama CityBuffalo
ECP Panama City NW Florida Beaches - BUF Buffalo
ECPBUF
Panama City NW Florida Beaches
Wed 12/23
6:00 am-11:10 am
1 stop4h 10m
Buffalo
Wed 12/31
12:00 am-11:00 pm
Nonstop0h 00m
$220
Panama CityBuffalo
ECP Panama City NW Florida Beaches - BUF Buffalo
ECPBUF
Panama City NW Florida Beaches
Sat 3/20
6:00 am-11:15 am
1 stop4h 15m
Buffalo
Wed 12/31
12:00 am-11:00 pm
Nonstop0h 00m
$238
Quickest round-trip
Panama CityBuffalo
ECP Panama City NW Florida Beaches - BUF Buffalo
ECPBUF
Panama City NW Florida Beaches
Fri 11/27
6:00 am-11:06 am
1 stop4h 06m
Buffalo
Wed 12/31
12:00 am-11:00 pm
Nonstop0h 00m
$270
Panama CityBuffalo
ECP Panama City NW Florida Beaches - BUF Buffalo
ECPBUF
Panama City NW Florida Beaches
Tue 12/8
1:58 pm-8:56 pm
1 stop5h 58m
Buffalo
Tue 12/15
6:30 am-1:17 pm
1 stop7h 47m
$295
Panama CityBuffalo
ECP Panama City NW Florida Beaches - BUF Buffalo
ECPBUF
Panama City NW Florida Beaches
Tue 12/8
7:55 am-3:15 pm
1 stop6h 20m
Buffalo
Tue 12/15
12:45 pm-6:15 pm
2 stops6h 30m
$300
Panama CityBuffalo
ECP Panama City NW Florida Beaches - BUF Buffalo
ECPBUF
Panama City NW Florida Beaches
Sat 3/20
1:30 pm-9:15 pm
2 stops6h 45m
Buffalo
Wed 12/31
12:00 am-11:00 pm
Nonstop0h 00m
$325
Panama CityBuffalo
ECP Panama City NW Florida Beaches - BUF Buffalo
ECPBUF
Panama City NW Florida Beaches
Sat 11/14
7:50 am-4:00 pm
1 stop7h 10m
Buffalo
Sat 11/21
12:35 pm-9:35 pm
2 stops10h 00m
$443
Panama CityBuffalo
ECP Panama City NW Florida Beaches - BUF Buffalo
ECPBUF
Panama City NW Florida Beaches
Thu 12/24
11:45 am-6:50 pm
1 stop6h 05m
Buffalo
Mon 12/28
7:47 pm-11:40 pm
1 stop4h 53m
$641
Panama CityBuffalo
ECP Panama City NW Florida Beaches - BUF Buffalo
ECPBUF
Panama City NW Florida Beaches
Tue 11/10
9:06 am-10:59 pm
2 stops12h 53m
Buffalo
Wed 11/11
6:00 am-4:18 pm
2 stops11h 18m
$698
Showing 1-10 of 11 resultsSorted by cheapest first
Compare providers for flights from Panama City to Buffalo
Provider information is updated monthly. Please note that these providers often have deals for this flight, but the availability may vary on a day-by-day basis on Cheapflights.
Use the table below to compare price accuracy, trust ratings, and cancellation policies for each provider offering flight deals from Panama City to Buffalo in October.
| Provider | Price Accuracy | Trust Score* |
|---|---|---|
| Price Accuracy1 star | Trust Score*3 stars | |
| Price Accuracy2 stars | Trust Score*3 stars | |
| Price Accuracy3 stars | Trust Score*3 stars |
- Most accurate provider: When it comes to deals on Panama City, Florida-Buffalo flights, users find the pricing of FlightHub to be most consistent on Cheapflights vs. FlightHub Users can find the same prices on Panama City, Florida-Buffalo flight deals on Cheapflights vs. FlightHub >95% of the time. Price accuracy is based on data collected from Panama City, Florida-Buffalo flight searches over the past month and is updated monthly.
- Most trusted provider: When it comes to deals on Panama City, Florida-Buffalo flights, Cheapflights users trust FlightHub the most. FlightHub has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for Panama City, Florida-Buffalo flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.
Best time to book a flight from Panama City to Buffalo
Have a flexible travel schedule? Discover the best time to fly to Buffalo from Panama City with our price prediction graph.
ECP-BUF
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.
Reviews of airlines servicing Buffalo
Get insights into the airlines that provide service to Buffalo. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Buffalo. Reviews last updated October 30, 2026.
Read reviews from past customers who have flown American Airlines from Panama City to Buffalo. Users can see the overall rating for each airline as well as how each is rated in terms of entertainment options, comfort, food, crew/service, and boarding process.
Boarding
7.4
Crew
7.9
Food
6.4
Comfort
7.1
Entertainment
6.8
Overall
7.0
Reviews
1 / 20
2.0
MediocreAnonymous,Jul 2023
DFW - JFK
Boarding
7.4
Crew
7.9
Food
6.4
Comfort
7.1
Entertainment
6.8
Overall
7.0
Reviews
1 / 20
2.0
MediocreAnonymous,Jul 2023
DFW - JFK
Related info for your journey
Find useful and relevant information for your journey from Panama City to Buffalo. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.
Traveling to a place near Buffalo?
Book flights to Buffalo if you plan to visit one of these locationsCheektowaga
Lockport
Amherst
Williamsville
Orchard Park
Eden
Bowmansville
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Other flights to Buffalo
Explore flights to Buffalo departing from other origins. Flights are based on user searches made on Cheapflights and were last updated on October 30, 2026.
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Panama City and Buffalo flights
Browse other Panama City and Buffalo flight options. Last updated on October 30, 2026.
Other flights from Panama City
Browse through other flights departing from Panama City. Flights are based on user searches made on Cheapflights and were last updated on October 30, 2026.
Popular flight searches
Check out other popular destinations found by fellow travelers in 2026
Top airline flying from Panama City to Buffalo
Discover the top airline that operate flights from Panama City to Buffalo. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 7,457,451 searches. Data last updated October 30, 2026.
| Airline | Cheapest | Average | Flexibility | On-time |
|---|---|---|---|---|
| Cheapest$366 | Average$558 | FlexibilityNo cancel fee | On-time71% |