$168+ Cheap flights from Panama City, FL to Buffalo (ECP - BUF)
This is the cheapest round-trip flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 11/9. Fares are subject to change and may not be available on all flights or dates of travel.
ECP — BUF
Oct 18 — Oct 251
Round-trip
1 adult, Economy
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Find cheap flights from Panama City to Buffalo with Cheapflights
1. Tell us where you want to go
Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”2. Select your favorite providers
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Review each provider’s pricing and select the best option for you! Book through your favorite provider’s website for a seamless experience.Cheap flight deals from Panama City to Buffalo
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Best
Last-minute
One-way
Cheapest flights from Panama City to BuffaloExplore the most affordable flight options available from Panama City to Buffalo. Find the lowest fares from popular airlines and budget airlines, with prices last updated on September 18, 2026.
Explore the most affordable flight options available from Panama City to Buffalo. Find the lowest fares from popular airlines and budget airlines, with prices last updated on September 18, 2026.
This Delta deal was found by Cheapflights users on 9/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 10/275:34 pm -
1 stop5h 25m
Tue 11/36:00 am -
1 stop4h 07m
Deal found 9/16![Delta logo]()
$293
This Delta deal was found by Cheapflights users on 9/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/316:00 am -
1 stop4h 16m
Tue 11/36:00 am -
1 stop6h 43m
Deal found 9/16![Delta logo]()
$300
This Delta deal was found by Cheapflights users on 9/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/176:00 am -
1 stop4h 16m
Sat 10/245:20 pm -
1 stop6h 58m
Deal found 9/15![Delta logo]()
$307
This Delta deal was found by Cheapflights users on 9/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 10/196:00 am -
1 stop4h 13m
Tue 10/275:20 pm -
1 stop6h 58m
Deal found 9/16![Delta logo]()
$314
This American Airlines deal was found by Cheapflights users on 9/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/317:15 am -
2 stops10h 54m
Tue 11/36:58 pm -
1 stop4h 54m
Deal found 9/16![American Airlines logo]()
$362
This Southwest deal was found by Cheapflights users on 9/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/175:55 am -
2 stops7h 40m
Sat 10/247:20 am -
1 stop4h 20m
Deal found 9/15![Southwest logo]()
$365
This American Airlines deal was found by Cheapflights users on 9/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 12/2012:12 pm -
1 stop6h 10m
Thu 12/317:42 pm -
1 stop4h 58m
Deal found 9/14![American Airlines logo]()
$418
This United Airlines deal was found by Cheapflights users on 9/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/319:06 am -
2 stops10h 45m
Tue 11/36:30 am -
2 stops10h 48m
Deal found 9/16![United Airlines logo]()
$425
Best flights from Panama City to BuffaloDiscover carefully curated flight deals from Panama City to Buffalo that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated September 18, 2026.
Discover carefully curated flight deals from Panama City to Buffalo that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated September 18, 2026.
This Delta deal was found by Cheapflights users on 9/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/176:00 am -
1 stop4h 16m
Sat 10/245:20 pm -
1 stop6h 58m
Deal found 9/15![Delta logo]()
$307
This Southwest deal was found by Cheapflights users on 9/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected ” under the list of providers to see comparable flight deals.
Sat 10/175:55 am -
2 stops7h 40m
Sat 10/247:20 am -
1 stop4h 20m
Deal found 9/15![Southwest logo]()
$365
This United Airlines deal was found by Cheapflights users on 9/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/319:06 am -
2 stops10h 45m
Tue 11/36:30 am -
2 stops10h 48m
Deal found 9/16![United Airlines logo]()
$425
This American Airlines deal was found by Cheapflights users on 9/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 12/2012:12 pm -
1 stop6h 10m
Thu 12/317:42 pm -
1 stop4h 58m
Deal found 9/16![American Airlines logo]()
$508
This Delta deal was found by Cheapflights users on 9/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 10/196:00 am -
1 stop4h 13m
Tue 10/275:20 pm -
1 stop6h 58m
Deal found 9/16![Delta logo]()
$314
This Southwest deal was found by Cheapflights users on 9/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 12/227:35 am -
2 stops10h 15m
Mon 12/286:05 am -
2 stops9h 15m
Deal found 9/14![Southwest logo]()
$569
This United Airlines deal was found by Cheapflights users on 9/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 11/109:06 am -
2 stops12h 53m
Wed 11/116:00 am -
2 stops11h 18m
Deal found 9/16![United Airlines logo]()
$622
This Southwest deal was found by Cheapflights users on 9/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/237:35 am -
2 stops7h 00m
Mon 12/286:05 am -
2 stops9h 15m
Deal found 9/14![Southwest logo]()
$583
Last-minute flights from Panama City to BuffaloDiscover last-minute flight deals from Panama City to Buffalo. Data last updated September 18, 2026 and is based on user searches.
Discover last-minute flight deals from Panama City to Buffalo. Data last updated September 18, 2026 and is based on user searches.
This Southwest deal was found by Cheapflights users on 9/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/237:45 am -
1 stop6h 40m
Fri 10/22:20 pm -
2 stops8h 50m
Deal found 9/17![Southwest logo]()
$670
This American Airlines deal was found by Cheapflights users on 9/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/238:29 am -
1 stop6h 11m
Fri 10/26:30 am -
1 stop6h 02m
Deal found 9/17![American Airlines logo]()
$679
This Delta deal was found by Cheapflights users on 9/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/176:00 am -
1 stop4h 16m
Sat 10/245:20 pm -
1 stop6h 58m
Deal found 9/15![Delta logo]()
$307
This Southwest deal was found by Cheapflights users on 9/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/175:55 am -
2 stops7h 40m
Sat 10/247:20 am -
1 stop4h 20m
Deal found 9/15![Southwest logo]()
$365
This Delta deal was found by Cheapflights users on 9/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 10/196:00 am -
1 stop4h 13m
Tue 10/275:20 pm -
1 stop6h 58m
Deal found 9/16![Delta logo]()
$314
This Delta deal was found by Cheapflights users on 9/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 10/275:34 pm -
1 stop5h 25m
Tue 11/36:00 am -
1 stop4h 07m
Deal found 9/16![Delta logo]()
$293
This United Airlines deal was found by Cheapflights users on 9/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 10/279:06 am -
2 stops12h 53m
Tue 11/36:30 am -
2 stops10h 48m
Deal found 9/16![United Airlines logo]()
$677
This Delta deal was found by Cheapflights users on 9/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/316:00 am -
1 stop4h 16m
Tue 11/36:00 am -
1 stop6h 43m
Deal found 9/16![Delta logo]()
$300
This American Airlines deal was found by Cheapflights users on 9/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/317:15 am -
2 stops10h 54m
Tue 11/36:58 pm -
1 stop4h 54m
Deal found 9/16![American Airlines logo]()
$362
This United Airlines deal was found by Cheapflights users on 9/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/319:06 am -
2 stops10h 45m
Tue 11/36:30 am -
2 stops10h 48m
Deal found 9/16![United Airlines logo]()
$425
One-way flights from Panama City to BuffaloSearch for one-way flight options from Panama City to Buffalo. Find affordable one-way fares based on user searches. Data last updated September 18, 2026.
Search for one-way flight options from Panama City to Buffalo. Find affordable one-way fares based on user searches. Data last updated September 18, 2026.
This Delta deal was found by Cheapflights users on 9/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 11/96:55 pm -
1 stop4h 04m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/14![Delta logo]()
$168
This Southwest deal was found by Cheapflights users on 9/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 11/97:55 am -
1 stop6h 20m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/17![Southwest logo]()
$280
This American Airlines deal was found by Cheapflights users on 9/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 11/95:41 pm -
2 stops26h 56m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/14![American Airlines logo]()
$380
This United Airlines deal was found by Cheapflights users on 9/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 10/279:06 am -
2 stops12h 53m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/16![United Airlines logo]()
$465
Find flight deals from Panama City to Buffalo
Discover tips and strategies to find the most affordable flight options for your journey from Panama City (ECP) to Buffalo (BUF). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated September 18, 2026.
Most accurate provider | FlightHub 3 stars |
|---|---|
Most trusted provider | FlightHub 3 stars |
Round-trip from | $293 (Delta) |
One-way from | $168 (Delta) |
Cheapflights Fare Finder
Customize your flight search to find flights from Panama City to Buffalo that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 7,457,451 searches. Data last updated September 18, 2026.
Use the filters below to find and compare flights from Panama City to Buffalo that are best for you.
Fly from
Fly to
Route
Depart
Return
Cheapest round-trip
Quickest round-trip
Panama CityBuffalo
ECP Panama City NW Florida Beaches - BUF Buffalo
ECPBUF
Panama City NW Florida Beaches
Mon 11/9
6:55 pm-11:59 pm
1 stop4h 04m
Buffalo
Wed 12/31
12:00 am-11:00 pm
Nonstop0h 00m
$168
Panama CityBuffalo
ECP Panama City NW Florida Beaches - BUF Buffalo
ECPBUF
Panama City NW Florida Beaches
Mon 11/9
7:55 am-3:15 pm
1 stop6h 20m
Buffalo
Wed 12/31
12:00 am-11:00 pm
Nonstop0h 00m
$280
Panama CityBuffalo
ECP Panama City NW Florida Beaches - BUF Buffalo
ECPBUF
Panama City NW Florida Beaches
Sat 10/17
6:00 am-11:16 am
1 stop4h 16m
Buffalo
Sat 10/24
5:20 pm-11:18 pm
1 stop6h 58m
$307
Panama CityBuffalo
ECP Panama City NW Florida Beaches - BUF Buffalo
ECPBUF
Panama City NW Florida Beaches
Mon 10/19
6:00 am-11:13 am
1 stop4h 13m
Buffalo
Tue 10/27
5:20 pm-11:18 pm
1 stop6h 58m
$314
Panama CityBuffalo
ECP Panama City NW Florida Beaches - BUF Buffalo
ECPBUF
Panama City NW Florida Beaches
Sat 10/17
5:55 am-2:35 pm
2 stops7h 40m
Buffalo
Sat 10/24
7:20 am-10:40 am
1 stop4h 20m
$365
Panama CityBuffalo
ECP Panama City NW Florida Beaches - BUF Buffalo
ECPBUF
Panama City NW Florida Beaches
Mon 11/9
5:41 pm-9:37 pm
2 stops26h 56m
Buffalo
Wed 12/31
12:00 am-11:00 pm
Nonstop0h 00m
$380
Panama CityBuffalo
ECP Panama City NW Florida Beaches - BUF Buffalo
ECPBUF
Panama City NW Florida Beaches
Sat 10/31
9:06 am-8:51 pm
2 stops10h 45m
Buffalo
Tue 11/3
6:30 am-4:18 pm
2 stops10h 48m
$425
Panama CityBuffalo
ECP Panama City NW Florida Beaches - BUF Buffalo
ECPBUF
Panama City NW Florida Beaches
Tue 10/27
9:06 am-10:59 pm
2 stops12h 53m
Buffalo
Wed 12/31
12:00 am-11:00 pm
Nonstop0h 00m
$465
Panama CityBuffalo
ECP Panama City NW Florida Beaches - BUF Buffalo
ECPBUF
Panama City NW Florida Beaches
Sun 12/20
12:12 pm-7:22 pm
1 stop6h 10m
Buffalo
Thu 12/31
7:42 pm-11:40 pm
1 stop4h 58m
$508
Panama CityBuffalo
ECP Panama City NW Florida Beaches - BUF Buffalo
ECPBUF
Panama City NW Florida Beaches
Tue 12/22
7:35 am-6:50 pm
2 stops10h 15m
Buffalo
Mon 12/28
6:05 am-2:20 pm
2 stops9h 15m
$569
Showing 1-10 of 12 resultsSorted by cheapest first
Compare providers for flights from Panama City to Buffalo
Provider information is updated monthly. Please note that these providers often have deals for this flight, but the availability may vary on a day-by-day basis on Cheapflights.
Use the table below to compare price accuracy, trust ratings, and cancellation policies for each provider offering flight deals from Panama City to Buffalo in September.
| Provider | Price Accuracy | Trust Score* |
|---|---|---|
| Price Accuracy1 star | Trust Score*3 stars | |
| Price Accuracy3 stars | Trust Score*3 stars |
- Most accurate provider: When it comes to deals on Panama City, Florida-Buffalo flights, users find the pricing of FlightHub to be most consistent on Cheapflights vs. FlightHub Users can find the same prices on Panama City, Florida-Buffalo flight deals on Cheapflights vs. FlightHub >95% of the time. Price accuracy is based on data collected from Panama City, Florida-Buffalo flight searches over the past month and is updated monthly.
- Most trusted provider: When it comes to deals on Panama City, Florida-Buffalo flights, Cheapflights users trust FlightHub the most. FlightHub has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for Panama City, Florida-Buffalo flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.
Best time to book a flight from Panama City to Buffalo
Have a flexible travel schedule? Discover the best time to fly to Buffalo from Panama City with our price prediction graph.
ECP-BUF
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.
Reviews of airlines servicing Buffalo
Get insights into the airlines that provide service to Buffalo. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Buffalo. Reviews last updated September 18, 2026.
Read reviews from past customers who have flown American Airlines from Panama City to Buffalo. Users can see the overall rating for each airline as well as how each is rated in terms of entertainment options, comfort, food, crew/service, and boarding process.
Crew
7.9
Overall
7.1
Food
6.4
Comfort
7.2
Entertainment
6.8
Boarding
7.4
Reviews
1 / 20
2.0
MediocreAnonymous,Jul 2023
DFW - JFK
Crew
7.9
Overall
7.1
Food
6.4
Comfort
7.2
Entertainment
6.8
Boarding
7.4
Reviews
1 / 20
2.0
MediocreAnonymous,Jul 2023
DFW - JFK
Related info for your journey
Find useful and relevant information for your journey from Panama City to Buffalo. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.
Traveling to a place near Buffalo?
Book flights to Buffalo if you plan to visit one of these locationsCheektowaga
Lockport
Amherst
Williamsville
Orchard Park
Eden
Bowmansville
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Other flights to Buffalo
Explore flights to Buffalo departing from other origins. Flights are based on user searches made on Cheapflights and were last updated on September 18, 2026.
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Panama City and Buffalo flights
Browse other Panama City and Buffalo flight options. Last updated on September 18, 2026.
Other flights from Panama City
Browse through other flights departing from Panama City. Flights are based on user searches made on Cheapflights and were last updated on September 18, 2026.
Popular flight searches
Check out other popular destinations found by fellow travelers in 2026
Top airline flying from Panama City to Buffalo
Discover the top airline that operate flights from Panama City to Buffalo. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 7,457,451 searches. Data last updated September 18, 2026.
| Airline | Cheapest | Average | Flexibility | On-time |
|---|---|---|---|---|
| Cheapest$366 | Average$558 | FlexibilityNo cancel fee | On-time71% |