$163+ Cheap flights from Panama City, FL to Buffalo (ECP - BUF)
This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 10/26. Fares are subject to change and may not be available on all flights or dates of travel.
ECP — BUF
Aug 29 — Sep 51
Round-trip
1 adult, Economy
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Find cheap flights from Panama City to Buffalo with Cheapflights
1. Tell us where you want to go
Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”2. Select your favorite providers
We find the providers serving your travel needs. Choose up to four travel providers to compare side-by-side for flights, hotels, or car rentals.3. Compare prices and book
Review each provider’s pricing and select the best option for you! Book through your favorite provider’s website for a seamless experience.Cheap flight deals from Panama City to Buffalo
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Best
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Cheapest flights from Panama City to BuffaloExplore the most affordable flight options available from Panama City to Buffalo. Find the lowest fares from popular airlines and budget airlines, with prices last updated on July 30, 2026.
Explore the most affordable flight options available from Panama City to Buffalo. Find the lowest fares from popular airlines and budget airlines, with prices last updated on July 30, 2026.
This Delta deal was found by Cheapflights users on 7/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 8/176:51 pm
ECP
- BUF
1 stop4h 08m
Delta
Wed 8/196:05 am
BUF
- ECP
1 stop5h 37m
Delta
Deal found 7/27![Delta logo]()
$325
This Delta deal was found by Cheapflights users on 7/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 8/176:51 pm
ECP
- BUF
1 stop4h 08m
Delta
Thu 8/207:19 pm
BUF
- ECP
1 stop5h 11m
Delta
Deal found 7/27![Delta logo]()
$330
This American Airlines deal was found by Cheapflights users on 7/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 8/2111:42 am
ECP
- BUF
1 stop5h 20m
American Airlines
Mon 8/246:59 pm
BUF
- ECP
1 stop4h 41m
American Airlines
Deal found 7/29![American Airlines logo]()
$355
This Southwest deal was found by Cheapflights users on 7/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 8/211:30 pm
ECP
- BUF
2 stops8h 10m
Southwest
Tue 8/258:05 am
BUF
- ECP
2 stops7h 55m
Southwest
Deal found 7/26![Southwest logo]()
$370
This United Airlines deal was found by Cheapflights users on 7/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 8/271:47 pm
ECP
- BUF
1 stop6h 20m
United Airlines
Mon 8/316:55 am
BUF
- ECP
1 stop7h 11m
United Airlines
Deal found 7/28![United Airlines logo]()
$405
This Delta deal was found by Cheapflights users on 7/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 8/176:51 pm
ECP
- BUF
1 stop4h 08m
Delta
Sat 8/225:13 pm
BUF
- ECP
1 stop5h 27m
Delta
Deal found 7/27![Delta logo]()
$411
This American Airlines deal was found by Cheapflights users on 7/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 9/411:42 am
ECP
- BUF
1 stop5h 20m
American Airlines
Mon 9/76:00 am
BUF
- ECP
1 stop7h 45m
American Airlines
Deal found 7/26![American Airlines logo]()
$425
This Southwest deal was found by Cheapflights users on 7/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 8/2210:30 am
ECP
- BUF
2 stops6h 10m
Southwest
Fri 8/286:30 am
BUF
- ECP
2 stops9h 50m
Southwest
Deal found 7/26![Southwest logo]()
$437
This Delta deal was found by Cheapflights users on 7/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 8/136:51 pm
ECP
- BUF
1 stop4h 08m
Delta
Thu 8/207:19 pm
BUF
- ECP
1 stop5h 11m
Delta
Deal found 7/27![Delta logo]()
$452
Best flights from Panama City to BuffaloDiscover carefully curated flight deals from Panama City to Buffalo that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated July 30, 2026.
Discover carefully curated flight deals from Panama City to Buffalo that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated July 30, 2026.
This Delta deal was found by Cheapflights users on 7/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 8/176:51 pm
ECP
- BUF
1 stop4h 08m
Delta
Thu 8/207:19 pm
BUF
- ECP
1 stop5h 11m
Delta
Deal found 7/27![Delta logo]()
$330
This American Airlines deal was found by Cheapflights users on 7/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 8/2111:42 am
ECP
- BUF
1 stop5h 20m
American Airlines
Mon 8/246:59 pm
BUF
- ECP
1 stop4h 41m
American Airlines
Deal found 7/29![American Airlines logo]()
$355
This Southwest deal was found by Cheapflights users on 7/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 8/211:30 pm
ECP
- BUF
2 stops8h 10m
Southwest
Tue 8/258:05 am
BUF
- ECP
2 stops7h 55m
Southwest
Deal found 7/26![Southwest logo]()
$370
This Delta deal was found by Cheapflights users on 7/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 8/196:00 am
ECP
- BUF
1 stop4h 08m
Delta
Thu 8/207:19 pm
BUF
- ECP
1 stop5h 11m
Delta
Deal found 7/27![Delta logo]()
$330
This Southwest deal was found by Cheapflights users on 7/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 8/2210:30 am
ECP
- BUF
2 stops6h 10m
Southwest
Fri 8/2812:30 pm
BUF
- ECP
1 stop7h 30m
Southwest
Deal found 7/26![Southwest logo]()
$438
This Delta deal was found by Cheapflights users on 7/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 8/176:51 pm
ECP
- BUF
1 stop4h 08m
Delta
Sat 8/225:13 pm
BUF
- ECP
1 stop5h 27m
Delta
Deal found 7/27![Delta logo]()
$411
This American Airlines deal was found by Cheapflights users on 7/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 8/1311:42 am
ECP
- BUF
2 stops9h 06m
American Airlines
Sun 8/236:00 am
BUF
- ECP
2 stops8h 50m
American Airlines
Deal found 7/25![American Airlines logo]()
$477
This Southwest deal was found by Cheapflights users on 7/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 9/41:30 pm
ECP
- BUF
2 stops7h 25m
Southwest
Mon 9/76:00 am
BUF
- ECP
2 stops8h 05m
Southwest
Deal found 7/26![Southwest logo]()
$478
Last-minute flights from Panama City to BuffaloDiscover last-minute flight deals from Panama City to Buffalo. Data last updated July 30, 2026 and is based on user searches.
Discover last-minute flight deals from Panama City to Buffalo. Data last updated July 30, 2026 and is based on user searches.
This Delta deal was found by Cheapflights users on 7/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 8/136:51 pm
ECP
- BUF
1 stop4h 08m
Delta
Thu 8/207:19 pm
BUF
- ECP
1 stop5h 11m
Delta
Deal found 7/27![Delta logo]()
$452
This Delta deal was found by Cheapflights users on 7/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 8/176:51 pm
ECP
- BUF
1 stop4h 08m
Delta
Tue 8/186:05 am
BUF
- ECP
1 stop5h 37m
Delta
Deal found 7/27![Delta logo]()
$325
This Delta deal was found by Cheapflights users on 7/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 8/176:51 pm
ECP
- BUF
1 stop4h 08m
Delta
Thu 8/207:19 pm
BUF
- ECP
1 stop5h 11m
Delta
Deal found 7/27![Delta logo]()
$330
This Delta deal was found by Cheapflights users on 7/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 8/176:51 pm
ECP
- BUF
1 stop4h 08m
Delta
Sat 8/225:13 pm
BUF
- ECP
1 stop5h 27m
Delta
Deal found 7/27![Delta logo]()
$411
This American Airlines deal was found by Cheapflights users on 7/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 8/1811:42 am
ECP
- BUF
2 stops11h 14m
American Airlines
Sat 8/226:59 pm
BUF
- ECP
1 stop4h 41m
American Airlines
Deal found 7/27![American Airlines logo]()
$466
This American Airlines deal was found by Cheapflights users on 7/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 8/2111:42 am
ECP
- BUF
1 stop5h 20m
American Airlines
Mon 8/246:59 pm
BUF
- ECP
1 stop4h 41m
American Airlines
Deal found 7/29![American Airlines logo]()
$355
This Southwest deal was found by Cheapflights users on 7/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 8/211:30 pm
ECP
- BUF
2 stops8h 10m
Southwest
Tue 8/259:45 am
BUF
- ECP
1 stop6h 15m
Southwest
Deal found 7/26![Southwest logo]()
$370
This Southwest deal was found by Cheapflights users on 7/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 8/2210:30 am
ECP
- BUF
2 stops6h 10m
Southwest
Fri 8/286:30 am
BUF
- ECP
2 stops9h 50m
Southwest
Deal found 7/26![Southwest logo]()
$437
This United Airlines deal was found by Cheapflights users on 7/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 8/271:47 pm
ECP
- BUF
1 stop6h 20m
United Airlines
Mon 8/316:55 am
BUF
- ECP
1 stop7h 11m
United Airlines
Deal found 7/28![United Airlines logo]()
$405
One-way flights from Panama City to BuffaloSearch for one-way flight options from Panama City to Buffalo. Find affordable one-way fares based on user searches. Data last updated July 30, 2026.
Search for one-way flight options from Panama City to Buffalo. Find affordable one-way fares based on user searches. Data last updated July 30, 2026.
This United Airlines deal was found by Cheapflights users on 7/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 8/271:47 pm
ECP
- BUF
1 stop6h 20m
United Airlines
Deal found 7/26![United Airlines logo]()
$163
This Delta deal was found by Cheapflights users on 7/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 9/176:20 pm
ECP
- BUF
1 stop4h 32m
Delta
Deal found 7/27![Delta logo]()
$168
This Southwest deal was found by Cheapflights users on 7/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 8/2710:00 am
ECP
- BUF
2 stops7h 25m
Southwest
Deal found 7/26![Southwest logo]()
$195
This American Airlines deal was found by Cheapflights users on 7/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 9/411:42 am
ECP
- BUF
1 stop5h 20m
American Airlines
Deal found 7/25![American Airlines logo]()
$209
This Southwest deal was found by Cheapflights users on 7/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 9/171:30 pm
ECP
- BUF
2 stops8h 15m
Southwest
Deal found 7/27![Southwest logo]()
$214
This American Airlines deal was found by Cheapflights users on 7/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 8/186:40 am
ECP
- BUF
1 stop4h 26m
American Airlines
Deal found 7/29![American Airlines logo]()
$249
This American Airlines deal was found by Cheapflights users on 7/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 12/284:09 pm
ECP
- BUF
1 stop6h 50m
American Airlines
Deal found 7/26![American Airlines logo]()
$265
This United Airlines deal was found by Cheapflights users on 7/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 9/1711:41 am
ECP
- BUF
3 stops11h 03m
United Airlines
Deal found 7/27![United Airlines logo]()
$906
This United Airlines deal was found by Cheapflights users on 7/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 10/269:06 am
ECP
- BUF
3 stops10h 30m
United Airlines
Deal found 7/28![United Airlines logo]()
$1,029
Find flight deals from Panama City to Buffalo
Discover tips and strategies to find the most affordable flight options for your journey from Panama City (ECP) to Buffalo (BUF). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated July 30, 2026.
Most accurate provider | FlightHub 3 stars |
|---|---|
Most trusted provider | FlightHub 3 stars |
Round-trip from | $325 (Delta) |
One-way from | $163 (United Airlines) |
Cheapflights Fare Finder
Customize your flight search to find flights from Panama City to Buffalo that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated July 30, 2026.
Use the filters below to find and compare flights from Panama City to Buffalo that are best for you.
Fly from
Fly to
Route
Depart
Return
Cheapest round-trip
Quickest round-trip
Panama CityBuffalo
ECP - BUF
ECPBUF
Panama City NW Florida Beaches
Mon 8/17
6:51 pm-11:59 pm
1 stop4h 08m
Buffalo
Thu 8/20
7:19 pm-11:30 pm
1 stop5h 11m
$330
Panama CityBuffalo
ECP - BUF
ECPBUF
Panama City NW Florida Beaches
Wed 8/19
6:00 am-11:08 am
1 stop4h 08m
Buffalo
Thu 8/20
7:19 pm-11:30 pm
1 stop5h 11m
$330
Panama CityBuffalo
ECP - BUF
ECPBUF
Panama City NW Florida Beaches
Fri 8/21
11:42 am-6:02 pm
1 stop5h 20m
Buffalo
Mon 8/24
6:59 pm-10:40 pm
1 stop4h 41m
$355
Panama CityBuffalo
ECP - BUF
ECPBUF
Panama City NW Florida Beaches
Fri 8/21
1:30 pm-10:40 pm
2 stops8h 10m
Buffalo
Tue 8/25
8:05 am-3:00 pm
2 stops7h 55m
$370
Panama CityBuffalo
ECP - BUF
ECPBUF
Panama City NW Florida Beaches
Mon 8/17
6:51 pm-11:59 pm
1 stop4h 08m
Buffalo
Sat 8/22
5:13 pm-9:40 pm
1 stop5h 27m
$411
Panama CityBuffalo
ECP - BUF
ECPBUF
Panama City NW Florida Beaches
Sat 8/22
10:30 am-5:40 pm
2 stops6h 10m
Buffalo
Fri 8/28
12:30 pm-7:00 pm
1 stop7h 30m
$438
Panama CityBuffalo
ECP - BUF
ECPBUF
Panama City NW Florida Beaches
Thu 8/13
11:42 am-9:48 pm
2 stops9h 06m
Buffalo
Sun 8/23
6:00 am-1:50 pm
2 stops8h 50m
$477
Panama CityBuffalo
ECP - BUF
ECPBUF
Panama City NW Florida Beaches
Fri 9/4
1:30 pm-9:55 pm
2 stops7h 25m
Buffalo
Mon 9/7
6:00 am-1:05 pm
2 stops8h 05m
$478
Cheapest one-way
Panama CityBuffalo
ECP - BUF
ECPBUF
Panama City NW Florida Beaches
Mon 10/26
7:15 am-3:06 pm
1 stop6h 51m
$163
Panama CityBuffalo
ECP - BUF
ECPBUF
Panama City NW Florida Beaches
Thu 8/27
1:47 pm-9:07 pm
1 stop6h 20m
$163
Showing 1-10 of 16 resultsSorted by cheapest first
Compare providers for flights from Panama City to Buffalo
Provider information is updated monthly. Please note that these providers often have deals for this flight, but the availability may vary on a day-by-day basis on Cheapflights.
Use the table below to compare price accuracy, trust ratings, and cancellation policies for each provider offering flight deals from Panama City to Buffalo in July.
| Provider | Price Accuracy | Trust Score* |
|---|---|---|
| Price Accuracy1 star | Trust Score*3 stars | |
| Price Accuracy3 stars | Trust Score*3 stars |
- Most accurate provider: When it comes to deals on Panama City, Florida-Buffalo flights, users find the pricing of FlightHub to be most consistent on Cheapflights vs. FlightHub Users can find the same prices on Panama City, Florida-Buffalo flight deals on Cheapflights vs. FlightHub >95% of the time. Price accuracy is based on data collected from Panama City, Florida-Buffalo flight searches over the past month and is updated monthly.
- Most trusted provider: When it comes to deals on Panama City, Florida-Buffalo flights, Cheapflights users trust FlightHub the most. FlightHub has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for Panama City, Florida-Buffalo flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.
Best time to book a flight from Panama City to Buffalo
Have a flexible travel schedule? Discover the best time to fly to Buffalo from Panama City with our price prediction graph.
ECP-BUF
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.
Reviews of airlines servicing Buffalo
Get insights into the airlines that provide service to Buffalo. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Buffalo. Reviews last updated July 30, 2026.
Read reviews from past customers who have flown American Airlines from Panama City to Buffalo. Users can see the overall rating for each airline as well as how each is rated in terms of entertainment options, comfort, food, crew/service, and boarding process.
Entertainment
6.8
Food
6.4
Boarding
7.5
Crew
7.9
Comfort
7.2
Overall
7.1
Reviews
1 / 20
2.0
MediocreAnonymous,Jul 2023
DFW - JFK
Entertainment
6.8
Food
6.4
Boarding
7.5
Crew
7.9
Comfort
7.2
Overall
7.1
Reviews
1 / 20
2.0
MediocreAnonymous,Jul 2023
DFW - JFK
Related info for your journey
Find useful and relevant information for your journey from Panama City to Buffalo. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.
Traveling to a place near Buffalo?
Book flights to Buffalo if you plan to visit one of these locationsLockport
Cheektowaga
Amherst
Williamsville
Orchard Park
Eden
Bowmansville
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Toggle through the tabs below to find thousands of options on Cheapflights for your next trip.
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Other flights to Buffalo
Explore flights to Buffalo departing from other origins. Flights are based on user searches made on Cheapflights and were last updated on July 30, 2026.
Complete your trip
Complete your trip to Buffalo by adding a car rental and/or hotel reservation to your travel itinerary.
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Find flights from Panama City to Buffalo, based on your preferred cabin class, be it economy, premium economy, business, or first class.
Panama City and Buffalo flights
Browse other Panama City and Buffalo flight options. Last updated on July 30, 2026.
Other flights from Panama City
Browse through other flights departing from Panama City. Flights are based on user searches made on Cheapflights and were last updated on July 30, 2026.
Popular flight searches
Check out other popular destinations found by fellow travelers in 2026
Top airline flying from Panama City to Buffalo
Discover the top airline that operate flights from Panama City to Buffalo. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated July 30, 2026.
| Airline | Cheapest | Average | Flexibility | On-time |
|---|---|---|---|---|
| Cheapest$361 | Average$558 | FlexibilityNo cancel fee | On-time71% |