$178+ Cheap flights from Buffalo to Panama City, FL (BUF - ECP)
This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 9/30. Fares are subject to change and may not be available on all flights or dates of travel.
BUF — ECP
Jul 5 — Jul 121
Round-trip
1 adult, Economy
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Find cheap flights from Buffalo to Panama City with Cheapflights
1. Tell us where you want to go
Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”2. Select your favorite providers
We find the providers serving your travel needs. Choose up to four travel providers to compare side-by-side for flights, hotels, or car rentals.3. Compare prices and book
Review each provider’s pricing and select the best option for you! Book through your favorite provider’s website for a seamless experience.Cheap flight deals from Buffalo to Panama City
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Best
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Cheapest flights from Buffalo to Panama CityExplore the most affordable flight options available from Buffalo to Panama City. Find the lowest fares from popular airlines and budget airlines, with prices last updated on June 5, 2026.
Explore the most affordable flight options available from Buffalo to Panama City. Find the lowest fares from popular airlines and budget airlines, with prices last updated on June 5, 2026.
This American Airlines deal was found by Cheapflights users on 6/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 6/237:32 pm
BUF
- ECP
1 stop5h 08m
American Airlines
Tue 6/307:05 am
ECP
- BUF
1 stop4h 49m
American Airlines
Deal found 6/2![American Airlines logo]()
$355
This American Airlines deal was found by Cheapflights users on 6/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 7/216:00 am
BUF
- ECP
1 stop7h 11m
American Airlines
Thu 7/307:05 am
ECP
- BUF
1 stop4h 46m
American Airlines
Deal found 6/3![American Airlines logo]()
$380
This American Airlines deal was found by Cheapflights users on 6/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 7/37:35 pm
BUF
- ECP
1 stop5h 02m
American Airlines
Wed 7/87:05 am
ECP
- BUF
1 stop5h 00m
American Airlines
Deal found 6/3![American Airlines logo]()
$381
This Southwest deal was found by Cheapflights users on 6/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 7/216:25 am
BUF
- ECP
2 stops8h 25m
Southwest
Wed 7/297:40 am
ECP
- BUF
1 stop5h 40m
Southwest
Deal found 6/5![Southwest logo]()
$386
This American Airlines deal was found by Cheapflights users on 6/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 7/146:01 am
BUF
- ECP
1 stop5h 26m
American Airlines
Sat 8/17:05 am
ECP
- BUF
1 stop4h 46m
American Airlines
Deal found 6/4![American Airlines logo]()
$391
This Delta deal was found by Cheapflights users on 6/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/294:30 pm
BUF
- ECP
1 stop4h 06m
Delta
Mon 11/26:00 am
ECP
- BUF
1 stop4h 15m
Delta
Deal found 6/4![Delta logo]()
$397
This Delta deal was found by Cheapflights users on 6/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 9/136:16 am
BUF
- ECP
1 stop5h 14m
Delta
Sat 9/195:30 pm
ECP
- BUF
1 stop5h 24m
Delta
Deal found 6/2![Delta logo]()
$402
This Delta deal was found by Cheapflights users on 6/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/246:00 am
BUF
- ECP
1 stop5h 15m
Delta
Sun 1/36:00 am
ECP
- BUF
1 stop4h 15m
Delta
Deal found 6/2![Delta logo]()
$407
This Southwest deal was found by Cheapflights users on 6/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 7/216:25 am
BUF
- ECP
2 stops8h 25m
Southwest
Thu 7/307:50 am
ECP
- BUF
1 stop7h 10m
Southwest
Deal found 6/3![Southwest logo]()
$412
Best flights from Buffalo to Panama CityDiscover carefully curated flight deals from Buffalo to Panama City that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated June 5, 2026.
Discover carefully curated flight deals from Buffalo to Panama City that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated June 5, 2026.
This American Airlines deal was found by Cheapflights users on 6/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 7/37:35 pm
BUF
- ECP
1 stop5h 02m
American Airlines
Wed 7/87:05 am
ECP
- BUF
1 stop5h 00m
American Airlines
Deal found 6/3![American Airlines logo]()
$381
This Southwest deal was found by Cheapflights users on 6/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 7/216:25 am
BUF
- ECP
2 stops8h 25m
Southwest
Wed 7/297:40 am
ECP
- BUF
1 stop5h 40m
Southwest
Deal found 6/5![Southwest logo]()
$386
This American Airlines deal was found by Cheapflights users on 6/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 6/237:32 pm
BUF
- ECP
1 stop5h 08m
American Airlines
Tue 6/307:05 am
ECP
- BUF
2 stops9h 46m
American Airlines
Deal found 6/1![American Airlines logo]()
$396
This Southwest deal was found by Cheapflights users on 6/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 7/216:25 am
BUF
- ECP
2 stops8h 25m
Southwest
Thu 7/3012:00 pm
ECP
- BUF
2 stops8h 40m
Southwest
Deal found 6/3![Southwest logo]()
$417
This American Airlines deal was found by Cheapflights users on 6/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 6/257:32 pm
BUF
- ECP
1 stop5h 08m
American Airlines
Mon 6/294:16 pm
ECP
- BUF
1 stop5h 19m
American Airlines
Deal found 6/1![American Airlines logo]()
$427
This Southwest deal was found by Cheapflights users on 6/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 7/76:25 am
BUF
- ECP
2 stops8h 25m
Southwest
Sat 7/117:00 am
ECP
- BUF
2 stops8h 50m
Southwest
Deal found 6/2![Southwest logo]()
$443
This American Airlines deal was found by Cheapflights users on 6/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 7/1411:10 am
BUF
- ECP
2 stops8h 12m
American Airlines
Sat 8/17:05 am
ECP
- BUF
1 stop4h 46m
American Airlines
Deal found 6/5![American Airlines logo]()
$432
This Southwest deal was found by Cheapflights users on 6/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 7/252:40 pm
BUF
- ECP
2 stops8h 20m
Southwest
Tue 7/282:25 pm
ECP
- BUF
2 stops7h 20m
Southwest
Deal found 6/3![Southwest logo]()
$443
This American Airlines deal was found by Cheapflights users on 6/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 7/16:26 am
BUF
- ECP
1 stop5h 02m
American Airlines
Tue 7/74:17 pm
ECP
- BUF
1 stop5h 34m
American Airlines
Deal found 6/2![American Airlines logo]()
$447
Last-minute flights from Buffalo to Panama CityDiscover last-minute flight deals from Buffalo to Panama City. Data last updated June 5, 2026 and is based on user searches.
Discover last-minute flight deals from Buffalo to Panama City. Data last updated June 5, 2026 and is based on user searches.
This American Airlines deal was found by Cheapflights users on 6/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 6/237:32 pm
BUF
- ECP
1 stop5h 08m
American Airlines
Tue 6/307:05 am
ECP
- BUF
1 stop4h 49m
American Airlines
Deal found 6/2![American Airlines logo]()
$355
This American Airlines deal was found by Cheapflights users on 6/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 7/37:35 pm
BUF
- ECP
1 stop5h 02m
American Airlines
Wed 7/87:05 am
ECP
- BUF
1 stop5h 00m
American Airlines
Deal found 6/3![American Airlines logo]()
$381
This American Airlines deal was found by Cheapflights users on 6/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 7/146:01 am
BUF
- ECP
1 stop5h 26m
American Airlines
Sat 8/17:05 am
ECP
- BUF
1 stop4h 46m
American Airlines
Deal found 6/4![American Airlines logo]()
$391
This American Airlines deal was found by Cheapflights users on 6/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 7/216:00 am
BUF
- ECP
1 stop7h 11m
American Airlines
Thu 7/307:05 am
ECP
- BUF
1 stop4h 46m
American Airlines
Deal found 6/3![American Airlines logo]()
$380
This Southwest deal was found by Cheapflights users on 6/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 7/216:25 am
BUF
- ECP
2 stops8h 25m
Southwest
Wed 7/297:40 am
ECP
- BUF
1 stop5h 40m
Southwest
Deal found 6/5![Southwest logo]()
$386
This Southwest deal was found by Cheapflights users on 6/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 7/216:25 am
BUF
- ECP
2 stops8h 25m
Southwest
Thu 7/307:50 am
ECP
- BUF
1 stop7h 10m
Southwest
Deal found 6/3![Southwest logo]()
$412
This American Airlines deal was found by Cheapflights users on 6/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 7/257:36 pm
BUF
- ECP
1 stop5h 01m
American Airlines
Tue 7/2811:00 am
ECP
- BUF
2 stops9h 07m
American Airlines
Deal found 6/3![American Airlines logo]()
$422
One-way flights from Buffalo to Panama CitySearch for one-way flight options from Buffalo to Panama City. Find affordable one-way fares based on user searches. Data last updated June 5, 2026.
Search for one-way flight options from Buffalo to Panama City. Find affordable one-way fares based on user searches. Data last updated June 5, 2026.
This Delta deal was found by Cheapflights users on 6/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/306:59 pm
BUF
- ECP
1 stop4h 57m
Delta
Deal found 6/2![Delta logo]()
$178
This Southwest deal was found by Cheapflights users on 6/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/306:50 am
BUF
- ECP
2 stops9h 10m
Southwest
Deal found 6/2![Southwest logo]()
$183
This American Airlines deal was found by Cheapflights users on 6/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 6/297:32 pm
BUF
- ECP
1 stop5h 08m
American Airlines
Deal found 6/3![American Airlines logo]()
$214
This American Airlines deal was found by Cheapflights users on 6/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 6/234:55 pm
BUF
- ECP
2 stops7h 45m
American Airlines
Deal found 6/2![American Airlines logo]()
$219
This Delta deal was found by Cheapflights users on 6/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 6/166:00 am
BUF
- ECP
1 stop5h 54m
Delta
Deal found 6/1![Delta logo]()
$244
This American Airlines deal was found by Cheapflights users on 6/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 6/1611:03 am
BUF
- ECP
2 stops8h 23m
American Airlines
Deal found 6/2![American Airlines logo]()
$249
This Southwest deal was found by Cheapflights users on 6/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 6/2912:15 pm
BUF
- ECP
2 stops10h 25m
Southwest
Deal found 6/3![Southwest logo]()
$260
This United Airlines deal was found by Cheapflights users on 6/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 6/166:00 am
BUF
- ECP
2 stops11h 23m
United Airlines
Deal found 6/3![United Airlines logo]()
$394
Find flight deals from Buffalo to Panama City
Discover tips and strategies to find the most affordable flight options for your journey from Buffalo (BUF) to Panama City (ECP). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated June 5, 2026.
Most accurate provider | FlightHub 3 stars |
|---|---|
Most trusted provider | FlightHub 3 stars |
Round-trip from | $355 (American Airlines) |
One-way from | $117 (American Airlines) |
Popular in | April |
Cheapest in | November |
Average price | $406 |
Cheapflights Fare Finder
Customize your flight search to find flights from Buffalo to Panama City that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated June 5, 2026.
Use the filters below to find and compare flights from Buffalo to Panama City that are best for you.
Fly from
Fly to
Route
Depart
Return
Cheapest round-trip
Quickest round-trip
BuffaloPanama City
BUF - ECP
BUFECP
Buffalo
Fri 7/3
7:35 pm-11:37 pm
1 stop5h 02m
Panama City NW Florida Beaches
Wed 7/8
7:05 am-1:05 pm
1 stop5h 00m
$381
BuffaloPanama City
BUF - ECP
BUFECP
Buffalo
Tue 7/21
6:25 am-1:50 pm
2 stops8h 25m
Panama City NW Florida Beaches
Wed 7/29
7:40 am-2:20 pm
1 stop5h 40m
$386
BuffaloPanama City
BUF - ECP
BUFECP
Buffalo
Tue 6/23
7:32 pm-11:40 pm
1 stop5h 08m
Panama City NW Florida Beaches
Tue 6/30
7:05 am-5:51 pm
2 stops9h 46m
$396
BuffaloPanama City
BUF - ECP
BUFECP
Buffalo
Tue 7/21
6:25 am-1:50 pm
2 stops8h 25m
Panama City NW Florida Beaches
Thu 7/30
12:00 pm-9:40 pm
2 stops8h 40m
$417
BuffaloPanama City
BUF - ECP
BUFECP
Buffalo
Thu 6/25
7:32 pm-11:40 pm
1 stop5h 08m
Panama City NW Florida Beaches
Mon 6/29
4:16 pm-10:35 pm
1 stop5h 19m
$427
BuffaloPanama City
BUF - ECP
BUFECP
Buffalo
Tue 7/14
11:10 am-6:22 pm
2 stops8h 12m
Panama City NW Florida Beaches
Sat 8/1
7:05 am-12:51 pm
1 stop4h 46m
$432
BuffaloPanama City
BUF - ECP
BUFECP
Buffalo
Tue 7/7
6:25 am-1:50 pm
2 stops8h 25m
Panama City NW Florida Beaches
Sat 7/11
7:00 am-4:50 pm
2 stops8h 50m
$443
BuffaloPanama City
BUF - ECP
BUFECP
Buffalo
Sat 7/25
2:40 pm-10:00 pm
2 stops8h 20m
Panama City NW Florida Beaches
Tue 7/28
2:25 pm-10:45 pm
2 stops7h 20m
$443
BuffaloPanama City
BUF - ECP
BUFECP
Buffalo
Wed 7/1
6:26 am-10:28 am
1 stop5h 02m
Panama City NW Florida Beaches
Tue 7/7
4:17 pm-10:51 pm
1 stop5h 34m
$447
Cheapest one-way
Quickest one-way
BuffaloPanama City
BUF - ECP
BUFECP
Buffalo
Wed 9/30
6:59 pm-10:56 pm
1 stop4h 57m
$178
Showing 1-10 of 17 resultsSorted by cheapest first
Compare providers for flights from Buffalo to Panama City
Provider information is updated monthly. Please note that these providers often have deals for this flight, but the availability may vary on a day-by-day basis on Cheapflights.
Use the table below to compare price accuracy, trust ratings, and cancellation policies for each provider offering flight deals from Buffalo to Panama City in June.
| Provider | Price Accuracy | Trust Score* |
|---|---|---|
| Price Accuracy1 star | Trust Score*3 stars | |
| Price Accuracy3 stars | Trust Score*3 stars |
- Most accurate provider: When it comes to deals on Buffalo-Panama City, Florida flights, users find the pricing of FlightHub to be most consistent on Cheapflights vs. FlightHub Users can find the same prices on Buffalo-Panama City, Florida flight deals on Cheapflights vs. FlightHub >95% of the time. Price accuracy is based on data collected from Buffalo-Panama City, Florida flight searches over the past month and is updated monthly.
- Most trusted provider: When it comes to deals on Buffalo-Panama City, Florida flights, Cheapflights users trust FlightHub the most. FlightHub has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for Buffalo-Panama City, Florida flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.
Best time to book a flight from Buffalo to Panama City
Have a flexible travel schedule? Discover the best time to fly to Panama City from Buffalo with our price prediction graph.
BUF-ECP
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.
Cheapflights Insights
Everything you need to know about your flight from Buffalo to Panama City
What is the cheapest month to book a flight from Buffalo to Panama City, Florida?
Currently, November is the cheapest month in which you can book a flight from Buffalo to Panama City, Florida (average of $349). Flying from Buffalo to Panama City, Florida in April is currently the most expensive (average of $637). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.
How much does it cost to fly round-trip from Buffalo to Panama City, Florida?
Reviews of airlines servicing Panama City
Get insights into the airlines that provide service to Panama City. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Panama City. Reviews last updated June 5, 2026.
Get a feel of what it's like to fly with Southwest,Delta, andAmerican Airlines from Buffalo to Panama City by reading reviews from past customers. Users have also rated airlines in terms of entertainment options, comfort, food, crew/service, and boarding process.
Food
7.0
Comfort
8.0
Boarding
8.1
Entertainment
7.5
Crew
8.6
Overall
8.0
Reviews
1 / 20
10.0
ExcellentWalter,May 2026
LAS - BUR
Food
7.0
Comfort
8.0
Boarding
8.1
Entertainment
7.5
Crew
8.6
Overall
8.0
Reviews
1 / 20
10.0
ExcellentWalter,May 2026
LAS - BUR
Food
7.0
Comfort
8.0
Boarding
8.1
Entertainment
7.5
Crew
8.6
Overall
8.0
Reviews
1 / 20
10.0
ExcellentWalter,May 2026
LAS - BUR
Food
7.0
Comfort
8.0
Boarding
8.1
Entertainment
7.5
Crew
8.6
Overall
8.0
Reviews
1 / 20
10.0
ExcellentWalter,May 2026
LAS - BUR
Related info for your journey
Find useful and relevant information for your journey from Buffalo to Panama City. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.
Traveling to a place near Panama City?
Book flights to Panama City if you plan to visit one of these locationsMexico Beach
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Complete your trip
Complete your trip to Panama City by adding a car rental and/or hotel reservation to your travel itinerary.
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Find flights from Buffalo to Panama City, based on your preferred cabin class, be it economy, premium economy, business, or first class.
Buffalo and Panama City flights
Browse other Buffalo and Panama City flight options. Last updated on June 5, 2026.
Other flights from Buffalo
Browse through other flights departing from Buffalo. Flights are based on user searches made on Cheapflights and were last updated on June 5, 2026.
Other flights to Panama City
Explore flights to Panama City departing from other origins. Flights are based on user searches made on Cheapflights and were last updated on June 5, 2026.
Popular flight searches
Check out other popular destinations found by fellow travelers in 2026
Top 3 airlines flying from Buffalo to Panama City
Discover the top 3 airlines that operate flights from Buffalo to Panama City. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated June 5, 2026.
| Airline | Cheapest | Average | Flexibility | On-time |
|---|---|---|---|---|
| Cheapest$222 | Average$425 | FlexibilityNo cancel fee | On-timeN/A | |
| Cheapest$286 | Average$487 | FlexibilityNo cancel fee | On-time71% | |
| Cheapest$381 | Average$473 | FlexibilityNo cancel fee | On-time63% |