HomeSearch by dateVacation packagesHotelsFlight dealsCar rentalTravel tips & news
Wilkes-Barre

$271+ Cheap flights from Des Moines (DSM) to Wilkes-Barre, PA

This is the cheapest round-trip flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 11/26. Fares are subject to change and may not be available on all flights or dates of travel.
DSM — ABE
Nov 21 — Nov 281
Fri 11/21
Fri 11/28
1 adult, Economy
We work with more than 300 partners to bring you better travel deals

Find cheap flights from Des Moines to Wilkes-Barre with Cheapflights

1. Tell us where you want to go

Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”

2. Select your favorite providers

We find the providers serving your travel needs. Choose up to four travel providers to compare side-by-side for flights, hotels, or car rentals.

3. Compare prices and book

Review each provider’s pricing and select the best option for you! Book through your favorite provider’s website for a seamless experience.

Find flight deals from Des Moines to Wilkes-Barre

Cheapest flights from Des Moines to Wilkes-Barre
Explore the most affordable flight options available from Des Moines to Wilkes-Barre. Find the lowest fares from popular airlines and budget airlines, with prices last updated on October 22, 2025.

This American Airlines deal was found by Cheapflights users on 10/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 11/262:15 pmDSM - AVP
1 stop7h 07mAmerican Airlines
Tue 12/26:16 pmAVP - DSM
1 stop6h 28mAmerican Airlines
Deal found 10/20$271
This American Airlines deal was found by Cheapflights users on 10/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 12/53:18 pmDSM - AVP
1 stop4h 52mAmerican Airlines
Sun 12/75:26 pmAVP - DSM
1 stop7h 59mAmerican Airlines
Deal found 10/20$297
This United Airlines deal was found by Cheapflights users on 10/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 11/263:15 pmDSM - AVP
1 stop5h 04mUnited Airlines
Tue 12/27:45 pmAVP - DSM
2 stops19h 35mUnited Airlines
Deal found 10/20$421
This United Airlines deal was found by Cheapflights users on 10/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/48:00 amDSM - AVP
2 stops9h 42mUnited Airlines
Thu 12/117:45 pmAVP - DSM
2 stops15h 44mUnited Airlines
Deal found 10/19$475
This American Airlines deal was found by Cheapflights users on 10/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/114:49 pmDSM - AVP
1 stop6h 07mAmerican Airlines
Mon 12/226:15 pmAVP - DSM
1 stop15h 00mAmerican Airlines
Deal found 10/21$476
This American Airlines deal was found by Cheapflights users on 10/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 12/128:50 amDSM - AVP
2 stops11h 20mAmerican Airlines
Mon 12/226:15 pmAVP - DSM
1 stop15h 00mAmerican Airlines
Deal found 10/21$551
This United Airlines deal was found by Cheapflights users on 10/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 12/58:00 amDSM - AVP
1 stop11h 49mUnited Airlines
Fri 12/127:45 pmAVP - DSM
2 stops16h 08mUnited Airlines
Deal found 10/21$573

Cheap flight deals from Des Moines to Wilkes-Barre

Keep the following information in mind while searching for Des Moines to Wilkes-Barre flight deals. Data was last updated October 22, 2025.

Most accurate provider

FlightHub
3 stars

Most trusted provider

FlightHub
3 stars

Round-trip from

$271
(American Airlines)
Provider with most accurate pricing for Des Moines-Wilkes-Barre Scranton flight deals.
Search Deals
Provider most trusted by Cheapflights users for Des Moines-Wilkes-Barre Scranton flights.
Search Deals
From Des Moines to Wilkes-Barre
Search Deals

Cheapflights Fare Finder

 
Customize your flight search to find flights from Des Moines to Wilkes-Barre that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated October 22, 2025.
Use the filters below to find and compare flights from Des Moines to Wilkes-Barre that are best for you.

Fly from

Des Moines

Fly to

Wilkes-Barre

Route

Depart

Return

Price

Des MoinesScranton

DSM - AVP

DSMAVP

Des Moines

Wed 11/26

2:15 pm-10:22 pm

1 stop7h 07m

Wilkes-Barre Scranton

Tue 12/2

6:16 pm-11:44 pm

1 stop6h 28m

$271

Des MoinesScranton

DSM - AVP

DSMAVP

Des Moines

Fri 12/5

3:18 pm-9:10 pm

1 stop4h 52m

Wilkes-Barre Scranton

Sun 12/7

5:26 pm-12:25 am

1 stop7h 59m

$297

Des MoinesScranton

DSM - AVP

DSMAVP

Des Moines

Sat 3/7

4:27 pm-9:30 pm

1 stop4h 03m

Wilkes-Barre Scranton

Wed 3/11

4:40 pm-9:52 pm

1 stop6h 12m

$366

Des MoinesScranton

DSM - AVP

DSMAVP

Des Moines

Wed 11/26

3:15 pm-9:19 pm

1 stop5h 04m

Wilkes-Barre Scranton

Tue 12/2

7:45 pm-2:20 pm

2 stops19h 35m

$421

Des MoinesScranton

DSM - AVP

DSMAVP

Des Moines

Sat 3/7

3:15 pm-11:22 pm

2 stops7h 07m

Wilkes-Barre Scranton

Wed 3/11

2:50 pm-9:50 pm

1 stop8h 00m

$421

Flights are sorted by cheapest round-trip flights first.

Deals found on 10/20

Best time to book a flight from Des Moines to Wilkes-Barre

Have a flexible travel schedule? Discover the best time to fly to Wilkes-Barre from Des Moines with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Des Moines to Wilkes-Barre
No data available for this route at this time. Please check back soon.

Related info for your journey

Find useful and relevant information for your journey from Des Moines to Wilkes-Barre. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airport do you fly from for flights from Des Moines to Wilkes-Barre?

    Des Moines (DSM), located 3.6 mi from the city center, is the airport you fly out of when you book flights from Des Moines to Wilkes-Barre. 2 airlines have flights from Des Moines to Wilkes-Barre on a regular basis. Booking flights from Des Moines to Wilkes-Barre should not be difficult; the airport handles an average of 0 outbound flights to Wilkes-Barre per day.

  • How long is the flight from Des Moines to Wilkes-Barre?

    American Airlines can get you from Des Moines to Wilkes-Barre in just under 7h 07m. Your travel time can differ by up to . Des Moines and Wilkes-Barre are separated by a distance of 927 mi.

  • Can I find deals for flights from Des Moines to Wilkes-Barre that include hotel bookings?

    Yes. In addition to deals on Des Moines to Wilkes-Barre flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Des Moines to Wilkes-Barre?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Des Moines to Wilkes-Barre.

  • Can I find deals for business class flights from Des Moines to Wilkes-Barre?

    Yes. Cheapflights offers flight deals from Des Moines to Wilkes-Barre by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

See more FAQs

Browse thousands of different options on Cheapflights for your next trip

Toggle through the tabs below to find thousands of options on Cheapflights for your next trip.

Alternative routes for Des Moines to Wilkes-Barre

See prices for flight routes from nearby airports that may be better suited for you.
Des Moines to LaGuardia flights
Omaha to LaGuardia flights
Des Moines to John F Kennedy Intl flights
Omaha to John F Kennedy Intl flights
Omaha to Newark flights
Cedar Rapids to John F Kennedy Intl flights
Des Moines to Reagan-National flights
Cedar Rapids to Newark flights
Omaha to Reagan-National flights
Des Moines to Dulles Intl flights
Omaha to Dulles Intl flights
Cedar Rapids to LaGuardia flights
Cedar Rapids to Reagan-National flights
Cedar Rapids to Dulles Intl flights
Des Moines to Philadelphia flights
Omaha to Philadelphia flights
Des Moines to Newark flights
Cedar Rapids to Philadelphia flights
Moline to Dulles Intl flights
Moline to Reagan-National flights
Moline to Newark flights
Moline to John F Kennedy Intl flights
Moline to LaGuardia flights
Moline to Philadelphia flights
Moline to Pittsburgh flights
Cedar Rapids to Allentown flights
Omaha to Pittsburgh flights
Omaha to Harrisburg flights
Des Moines to Pittsburgh flights
Des Moines to Allentown flights
Des Moines to Harrisburg flights
Cedar Rapids to Pittsburgh flights
Cedar Rapids to Harrisburg flights
Moline to Allentown flights
Omaha to State College flights
Cedar Rapids to State College flights
La Crosse to Newark flights
Des Moines to State College flights
La Crosse to John F Kennedy Intl flights
Sioux City to Newark flights
Omaha to Allentown flights
Cedar Rapids to Scranton flights
Waterloo to Newark flights
Des Moines to Scranton flights
Waterloo to John F Kennedy Intl flights
Waterloo to LaGuardia flights
Sioux City to LaGuardia flights
Waterloo to Philadelphia flights
Sioux City to Reagan-National flights

Top 2 airlines flying from Des Moines to Wilkes-Barre

Discover the top 2 airlines that operate flights from Des Moines to Wilkes-Barre. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated October 22, 2025.
AirlineCheapestAverageFlexibilityOn-time
United AirlinesCheapest$283Average$490FlexibilityNo cancel feeOn-time69%
American AirlinesCheapest$334Average$379FlexibilityNo cancel feeOn-time71%

100% Free

Cheapflights is completely free to use, so you can start saving the moment you arrive.

Book with Flexibility

Our users can plan ahead with confidence and find flights with no change fees

Travel Smart

Millions of people come to us for their flight needs every year. We help make travel planning easy by providing useful insights and data-driven graphs that can inform your decisions.