$182+ Cheap flights from Portland, ME to St. Louis (PWM - STL)
This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 8/28. Fares are subject to change and may not be available on all flights or dates of travel.
PWM — STL
May 27 — Jun 31
Round-trip
1 adult, Economy
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Find cheap flights from Portland to St. Louis with Cheapflights
1. Tell us where you want to go
Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”2. Select your favorite providers
We find the providers serving your travel needs. Choose up to four travel providers to compare side-by-side for flights, hotels, or car rentals.3. Compare prices and book
Review each provider’s pricing and select the best option for you! Book through your favorite provider’s website for a seamless experience.Cheap flight deals from Portland to St. Louis
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Best
Last-minute
One-way
Cheapest flights from Portland to St. LouisExplore the most affordable flight options available from Portland to St. Louis. Find the lowest fares from popular airlines and budget airlines, with prices last updated on April 27, 2026.
Explore the most affordable flight options available from Portland to St. Louis. Find the lowest fares from popular airlines and budget airlines, with prices last updated on April 27, 2026.
This American Airlines deal was found by Cheapflights users on 4/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 5/2010:24 am
PWM
- STL
1 stop5h 48m
American Airlines
Wed 5/276:15 am
STL
- PWM
1 stop7h 09m
American Airlines
Deal found 4/23![American Airlines logo]()
$259
This American Airlines deal was found by Cheapflights users on 4/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 5/291:35 pm
PWM
- STL
1 stop8h 17m
American Airlines
Tue 6/26:00 am
STL
- PWM
1 stop6h 04m
American Airlines
Deal found 4/23![American Airlines logo]()
$311
This Delta deal was found by Cheapflights users on 4/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 5/2611:03 am
PWM
- STL
1 stop5h 37m
Delta
Sat 6/64:15 pm
STL
- PWM
1 stop7h 28m
Delta
Deal found 4/25![Delta logo]()
$315
This Delta deal was found by Cheapflights users on 4/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 5/2611:03 am
PWM
- STL
1 stop5h 37m
Delta
Thu 6/44:25 pm
STL
- PWM
1 stop7h 18m
Delta
Deal found 4/23![Delta logo]()
$324
This Southwest deal was found by Cheapflights users on 4/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 6/107:10 pm
PWM
- STL
1 stop4h 50m
Southwest
Mon 6/155:20 pm
STL
- PWM
1 stop5h 45m
Southwest
Deal found 4/23![Southwest logo]()
$343
This Southwest deal was found by Cheapflights users on 4/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 5/263:55 pm
PWM
- STL
1 stop6h 10m
Southwest
Thu 6/44:25 pm
STL
- PWM
2 stops6h 40m
Southwest
Deal found 4/22![Southwest logo]()
$349
This Delta deal was found by Cheapflights users on 4/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 5/176:00 am
PWM
- STL
1 stop7h 20m
Delta
Tue 5/196:45 am
STL
- PWM
1 stop4h 10m
Delta
Deal found 4/22![Delta logo]()
$353
This United Airlines deal was found by Cheapflights users on 4/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 5/205:30 am
PWM
- STL
2 stops8h 17m
United Airlines
Wed 5/276:00 am
STL
- PWM
1 stop7h 26m
United Airlines
Deal found 4/23![United Airlines logo]()
$354
This American Airlines deal was found by Cheapflights users on 4/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 6/105:58 pm
PWM
- STL
1 stop6h 46m
American Airlines
Mon 6/155:03 pm
STL
- PWM
1 stop6h 39m
American Airlines
Deal found 4/26![American Airlines logo]()
$363
This Southwest deal was found by Cheapflights users on 4/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 8/55:45 am
PWM
- STL
2 stops9h 10m
Southwest
Wed 8/123:45 pm
STL
- PWM
1 stop5h 20m
Southwest
Deal found 4/24![Southwest logo]()
$368
Best flights from Portland to St. LouisDiscover carefully curated flight deals from Portland to St. Louis that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated April 27, 2026.
Discover carefully curated flight deals from Portland to St. Louis that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated April 27, 2026.
This United Airlines deal was found by Cheapflights users on 4/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 5/205:30 am
PWM
- STL
2 stops8h 17m
United Airlines
Wed 5/276:00 am
STL
- PWM
1 stop7h 26m
United Airlines
Deal found 4/23![United Airlines logo]()
$354
This Southwest deal was found by Cheapflights users on 4/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 6/87:40 am
PWM
- STL
1 stop7h 30m
Southwest
Mon 6/84:25 pm
STL
- PWM
2 stops6h 40m
Southwest
Deal found 4/22![Southwest logo]()
$420
This United Airlines deal was found by Cheapflights users on 4/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 5/2310:04 am
PWM
- STL
2 stops10h 19m
United Airlines
Wed 5/276:00 am
STL
- PWM
1 stop6h 25m
United Airlines
Deal found 4/23![United Airlines logo]()
$390
This United Airlines deal was found by Cheapflights users on 4/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 6/36:00 am
PWM
- STL
1 stop7h 11m
United Airlines
Sat 6/61:13 pm
STL
- PWM
1 stop7h 38m
United Airlines
Deal found 4/26![United Airlines logo]()
$405
This United Airlines deal was found by Cheapflights users on 4/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 5/265:15 am
PWM
- STL
2 stops7h 56m
United Airlines
Sat 6/61:13 pm
STL
- PWM
2 stops9h 38m
United Airlines
Deal found 4/26![United Airlines logo]()
$415
This United Airlines deal was found by Cheapflights users on 4/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 5/295:15 am
PWM
- STL
2 stops7h 56m
United Airlines
Tue 6/26:00 am
STL
- PWM
1 stop6h 25m
United Airlines
Deal found 4/23![United Airlines logo]()
$424
Last-minute flights from Portland to St. LouisDiscover last-minute flight deals from Portland to St. Louis. Data last updated April 27, 2026 and is based on user searches.
Discover last-minute flight deals from Portland to St. Louis. Data last updated April 27, 2026 and is based on user searches.
This Delta deal was found by Cheapflights users on 4/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 5/76:00 am
PWM
- STL
1 stop7h 20m
Delta
Wed 5/136:45 am
STL
- PWM
1 stop4h 10m
Delta
Deal found 4/22![Delta logo]()
$383
This Delta deal was found by Cheapflights users on 4/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 5/176:00 am
PWM
- STL
1 stop7h 20m
Delta
Tue 5/196:45 am
STL
- PWM
1 stop4h 10m
Delta
Deal found 4/22![Delta logo]()
$353
This American Airlines deal was found by Cheapflights users on 4/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 5/2010:24 am
PWM
- STL
1 stop5h 48m
American Airlines
Wed 5/276:15 am
STL
- PWM
1 stop7h 09m
American Airlines
Deal found 4/23![American Airlines logo]()
$259
This United Airlines deal was found by Cheapflights users on 4/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 5/205:30 am
PWM
- STL
2 stops8h 17m
United Airlines
Wed 5/276:00 am
STL
- PWM
1 stop7h 26m
United Airlines
Deal found 4/23![United Airlines logo]()
$354
This United Airlines deal was found by Cheapflights users on 4/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 5/235:03 pm
PWM
- STL
1 stop5h 20m
United Airlines
Wed 5/276:00 am
STL
- PWM
1 stop6h 25m
United Airlines
Deal found 4/22![United Airlines logo]()
$375
This Delta deal was found by Cheapflights users on 4/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 5/2611:03 am
PWM
- STL
1 stop5h 37m
Delta
Sat 6/64:15 pm
STL
- PWM
1 stop7h 28m
Delta
Deal found 4/25![Delta logo]()
$315
This Delta deal was found by Cheapflights users on 4/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 5/2611:03 am
PWM
- STL
1 stop5h 37m
Delta
Thu 6/44:25 pm
STL
- PWM
1 stop7h 18m
Delta
Deal found 4/23![Delta logo]()
$324
This Southwest deal was found by Cheapflights users on 4/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 5/263:55 pm
PWM
- STL
1 stop6h 10m
Southwest
Thu 6/44:25 pm
STL
- PWM
2 stops6h 40m
Southwest
Deal found 4/22![Southwest logo]()
$349
This American Airlines deal was found by Cheapflights users on 4/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 5/267:19 pm
PWM
- STL
1 stop5h 35m
American Airlines
Thu 6/46:00 am
STL
- PWM
1 stop5h 40m
American Airlines
Deal found 4/22![American Airlines logo]()
$372
This American Airlines deal was found by Cheapflights users on 4/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 5/291:35 pm
PWM
- STL
1 stop8h 17m
American Airlines
Tue 6/26:00 am
STL
- PWM
1 stop6h 04m
American Airlines
Deal found 4/23![American Airlines logo]()
$311
One-way flights from Portland to St. LouisSearch for one-way flight options from Portland to St. Louis. Find affordable one-way fares based on user searches. Data last updated April 27, 2026.
Search for one-way flight options from Portland to St. Louis. Find affordable one-way fares based on user searches. Data last updated April 27, 2026.
This United Airlines deal was found by Cheapflights users on 4/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 8/289:15 am
PWM
- STL
1 stop7h 23m
United Airlines
Deal found 4/22![United Airlines logo]()
$182
This American Airlines deal was found by Cheapflights users on 4/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 7/61:25 pm
PWM
- STL
1 stop8h 30m
American Airlines
Deal found 4/27![American Airlines logo]()
$214
This United Airlines deal was found by Cheapflights users on 4/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 7/185:15 am
PWM
- STL
2 stops7h 52m
United Airlines
Deal found 4/23![United Airlines logo]()
$219
This Delta deal was found by Cheapflights users on 4/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 6/216:00 am
PWM
- STL
1 stop7h 50m
Delta
Deal found 4/27![Delta logo]()
$224
This Kiwi.com deal was found by Cheapflights users on 4/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 5/65:01 pm
PWM
- STL
3 stops24h 53m
Multiple Airlines
Deal found 4/22![Multiple Airlines logo]()
$238
This Southwest deal was found by Cheapflights users on 4/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 8/63:40 pm
PWM
- STL
2 stops8h 25m
Southwest
Deal found 4/26![Southwest logo]()
$239
This United Airlines deal was found by Cheapflights users on 4/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 5/611:08 am
PWM
- STL
2 stops8h 45m
United Airlines
Deal found 4/22![United Airlines logo]()
$259
This Kiwi.com deal was found by Cheapflights users on 4/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 8/287:00 am
PWM
- STL
3 stops37h 23m
Multiple Airlines
Deal found 4/22![Multiple Airlines logo]()
$274
This Kiwi.com deal was found by Cheapflights users on 4/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 8/63:11 pm
PWM
- STL
3 stops28h 25m
Multiple Airlines
Deal found 4/26![Multiple Airlines logo]()
$275
Find flight deals from Portland to St. Louis
Discover tips and strategies to find the most affordable flight options for your journey from Portland (PWM) to St. Louis (STL). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated April 27, 2026.
Most accurate provider | FlightHub 3 stars |
|---|---|
Most trusted provider | FlightHub 3 stars |
Round-trip from | $259 (American Airlines) |
One-way from | $182 (United Airlines) |
Popular in | June |
Cheapest in | September |
Average price | $568 |
Cheapflights Fare Finder
Customize your flight search to find flights from Portland to St. Louis that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated April 27, 2026.
Use the filters below to find and compare flights from Portland to St. Louis that are best for you.
Fly from
Fly to
Route
Depart
Return
Cheapest round-trip
PortlandSt. Louis
PWM - STL
PWMSTL
Portland
Wed 5/20
5:30 am-12:47 pm
2 stops8h 17m
Lambert-St Louis
Wed 5/27
6:00 am-2:26 pm
1 stop7h 26m
$354
PortlandSt. Louis
PWM - STL
PWMSTL
Portland
Sat 5/23
10:04 am-7:23 pm
2 stops10h 19m
Lambert-St Louis
Wed 5/27
6:00 am-1:25 pm
1 stop6h 25m
$390
PortlandSt. Louis
PWM - STL
PWMSTL
Portland
Wed 6/3
6:00 am-12:11 pm
1 stop7h 11m
Lambert-St Louis
Sat 6/6
1:13 pm-9:51 pm
1 stop7h 38m
$405
PortlandSt. Louis
PWM - STL
PWMSTL
Portland
Tue 5/26
5:15 am-12:11 pm
2 stops7h 56m
Lambert-St Louis
Sat 6/6
1:13 pm-11:51 pm
2 stops9h 38m
$415
Quickest round-trip
PortlandSt. Louis
PWM - STL
PWMSTL
Portland
Mon 6/8
7:40 am-2:10 pm
1 stop7h 30m
Lambert-St Louis
Mon 6/8
4:25 pm-12:05 am
2 stops6h 40m
$420
PortlandSt. Louis
PWM - STL
PWMSTL
Portland
Fri 5/29
5:15 am-12:11 pm
2 stops7h 56m
Lambert-St Louis
Tue 6/2
6:00 am-1:25 pm
1 stop6h 25m
$424
Cheapest one-way
PortlandSt. Louis
PWM - STL
PWMSTL
Portland
Fri 8/28
9:15 am-3:38 pm
1 stop7h 23m
$182
Quickest one-way
PortlandSt. Louis
PWM - STL
PWMSTL
Portland
Fri 9/4
6:00 am-10:41 am
1 stop5h 41m
$214
PortlandSt. Louis
PWM - STL
PWMSTL
Portland
Sat 7/18
6:15 am-12:30 pm
1 stop7h 15m
$214
PortlandSt. Louis
PWM - STL
PWMSTL
Portland
Sun 6/21
6:00 am-12:50 pm
1 stop7h 50m
$224
Showing 1-10 of 13 resultsSorted by cheapest first
Compare providers for flights from Portland to St. Louis
Provider information is updated monthly. Please note that these providers often have deals for this flight, but the availability may vary on a day-by-day basis on Cheapflights.
Use the table below to compare price accuracy, trust ratings, and cancellation policies for each provider offering flight deals from Portland to St. Louis in April.
| Provider | Price Accuracy | Trust Score* |
|---|---|---|
| Price Accuracy1 star | Trust Score*3 stars | |
| Price Accuracy3 stars | Trust Score*3 stars |
- Most accurate provider: When it comes to deals on Portland, Maine-St. Louis flights, users find the pricing of FlightHub to be most consistent on Cheapflights vs. FlightHub Users can find the same prices on Portland, Maine-St. Louis flight deals on Cheapflights vs. FlightHub >95% of the time. Price accuracy is based on data collected from Portland, Maine-St. Louis flight searches over the past month and is updated monthly.
- Most trusted provider: When it comes to deals on Portland, Maine-St. Louis flights, Cheapflights users trust FlightHub the most. FlightHub has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for Portland, Maine-St. Louis flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.
Best time to book a flight from Portland to St. Louis
Have a flexible travel schedule? Discover the best time to fly to St. Louis from Portland with our price prediction graph.
PWM-STL
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.
Cheapflights Insights
Everything you need to know about your flight from Portland to St. Louis
What is the cheapest month to book a flight from Portland, Maine to St. Louis?
Currently, September is the cheapest month in which you can book a flight from Portland, Maine to St. Louis (average of $333). Flying from Portland, Maine to St. Louis in June is currently the most expensive (average of $704). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.
How much does it cost to fly round-trip from Portland, Maine to St. Louis?
Reviews of airlines servicing St. Louis
Get insights into the airlines that provide service to St. Louis. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to St. Louis. Reviews last updated April 27, 2026.
Get a feel of what it's like to fly with Southwest,Delta, andAmerican Airlines from Portland to St. Louis by reading reviews from past customers. Users have also rated airlines in terms of entertainment options, comfort, food, crew/service, and boarding process.
Entertainment
7.5
Food
7.0
Crew
8.6
Boarding
8.1
Comfort
8.0
Overall
8.0
Reviews
1 / 20
2.0
MediocreDominic,Mar 2026
MCO - SMF
Entertainment
7.5
Food
7.0
Crew
8.6
Boarding
8.1
Comfort
8.0
Overall
8.0
Reviews
1 / 20
2.0
MediocreDominic,Mar 2026
MCO - SMF
Entertainment
7.5
Food
7.0
Crew
8.6
Boarding
8.1
Comfort
8.0
Overall
8.0
Reviews
1 / 20
2.0
MediocreDominic,Mar 2026
MCO - SMF
Entertainment
7.5
Food
7.0
Crew
8.6
Boarding
8.1
Comfort
8.0
Overall
8.0
Reviews
1 / 20
2.0
MediocreDominic,Mar 2026
MCO - SMF
Related info for your journey
Find useful and relevant information for your journey from Portland to St. Louis. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.
Traveling to a place near St. Louis?
Book flights to St. Louis if you plan to visit one of these locationsEdwardsville
O'Fallon
Fenton
Swansea
Fairview Heights
Maryland Heights
Collinsville
Eureka
Wentzville
Glencoe
Chesterfield
Alton
Farmington
Festus
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Find flights from Portland to St. Louis, based on your preferred cabin class, be it economy, premium economy, business, or first class.
Portland and St. Louis flights
Browse other Portland and St. Louis flight options. Last updated on April 27, 2026.
Other flights from Portland
Browse through other flights departing from Portland. Flights are based on user searches made on Cheapflights and were last updated on April 27, 2026.
Popular flight searches
Check out other popular destinations found by fellow travelers in 2026
Other flights to St. Louis
Explore flights to St. Louis departing from other origins. Flights are based on user searches made on Cheapflights and were last updated on April 27, 2026.
Top 3 airlines flying from Portland to St. Louis
Discover the top 3 airlines that operate flights from Portland to St. Louis. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated April 27, 2026.
| Airline | Cheapest | Average | Flexibility | On-time |
|---|---|---|---|---|
| Cheapest$236 | Average$386 | FlexibilityNo cancel fee | On-timeN/A | |
| Cheapest$296 | Average$446 | FlexibilityNo cancel fee | On-time71% | |
| Cheapest$348 | Average$499 | FlexibilityNo cancel fee | On-time63% |