$138+ Cheap flights from Portland, ME to St. Louis (PWM - STL)
This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 8/5. Fares are subject to change and may not be available on all flights or dates of travel.
PWM — STL
Jul 12 — Jul 191
Round-trip
1 adult, Economy
We work with more than 300 partners to bring you better travel deals
Find cheap flights from Portland to St. Louis with Cheapflights
1. Tell us where you want to go
Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”2. Select your favorite providers
We find the providers serving your travel needs. Choose up to four travel providers to compare side-by-side for flights, hotels, or car rentals.3. Compare prices and book
Review each provider’s pricing and select the best option for you! Book through your favorite provider’s website for a seamless experience.Cheap flight deals from Portland to St. Louis
Cheapest
Best
Last-minute
One-way
Cheapest flights from Portland to St. LouisExplore the most affordable flight options available from Portland to St. Louis. Find the lowest fares from popular airlines and budget airlines, with prices last updated on June 12, 2026.
Explore the most affordable flight options available from Portland to St. Louis. Find the lowest fares from popular airlines and budget airlines, with prices last updated on June 12, 2026.
This American Airlines deal was found by Cheapflights users on 6/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/146:06 am
PWM
- STL
1 stop5h 01m
American Airlines
Wed 10/215:46 pm
STL
- PWM
1 stop4h 38m
American Airlines
Deal found 6/10![American Airlines logo]()
$275
This United Airlines deal was found by Cheapflights users on 6/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/145:08 pm
PWM
- STL
1 stop5h 13m
United Airlines
Wed 10/216:00 am
STL
- PWM
2 stops7h 38m
United Airlines
Deal found 6/11![United Airlines logo]()
$280
This Southwest deal was found by Cheapflights users on 6/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/145:50 am
PWM
- STL
1 stop6h 40m
Southwest
Wed 10/2111:50 am
STL
- PWM
2 stops8h 40m
Southwest
Deal found 6/10![Southwest logo]()
$282
This Southwest deal was found by Cheapflights users on 6/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 10/266:30 am
PWM
- STL
1 stop6h 35m
Southwest
Mon 11/26:40 am
STL
- PWM
1 stop5h 25m
Southwest
Deal found 6/8![Southwest logo]()
$333
This Southwest deal was found by Cheapflights users on 6/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 7/75:30 am
PWM
- STL
1 stop7h 00m
Southwest
Tue 7/144:00 pm
STL
- PWM
1 stop4h 35m
Southwest
Deal found 6/9![Southwest logo]()
$339
This United Airlines deal was found by Cheapflights users on 6/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 8/56:00 am
PWM
- STL
1 stop7h 11m
United Airlines
Sun 8/97:20 am
STL
- PWM
1 stop6h 10m
United Airlines
Deal found 6/9![United Airlines logo]()
$351
This Southwest deal was found by Cheapflights users on 6/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 9/113:40 pm
PWM
- STL
1 stop7h 00m
Southwest
Mon 9/144:15 pm
STL
- PWM
1 stop5h 10m
Southwest
Deal found 6/8![Southwest logo]()
$361
This American Airlines deal was found by Cheapflights users on 6/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 8/51:30 pm
PWM
- STL
1 stop8h 14m
American Airlines
Sun 8/95:42 pm
STL
- PWM
1 stop4h 55m
American Airlines
Deal found 6/8![American Airlines logo]()
$380
Best flights from Portland to St. LouisDiscover carefully curated flight deals from Portland to St. Louis that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated June 12, 2026.
Discover carefully curated flight deals from Portland to St. Louis that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated June 12, 2026.
This Southwest deal was found by Cheapflights users on 6/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 7/75:30 am
PWM
- STL
1 stop7h 00m
Southwest
Tue 7/144:00 pm
STL
- PWM
1 stop4h 35m
Southwest
Deal found 6/9![Southwest logo]()
$339
This United Airlines deal was found by Cheapflights users on 6/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 8/55:15 am
PWM
- STL
2 stops7h 56m
United Airlines
Sun 8/96:01 am
STL
- PWM
1 stop6h 24m
United Airlines
Deal found 6/8![United Airlines logo]()
$385
This Delta deal was found by Cheapflights users on 6/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 7/221:12 pm
PWM
- STL
1 stop8h 23m
Delta
Sat 7/256:30 am
STL
- PWM
1 stop4h 25m
Delta
Deal found 6/7![Delta logo]()
$427
This Southwest deal was found by Cheapflights users on 6/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 7/75:30 am
PWM
- STL
1 stop7h 00m
Southwest
Mon 7/135:20 pm
STL
- PWM
1 stop5h 50m
Southwest
Deal found 6/11![Southwest logo]()
$383
This United Airlines deal was found by Cheapflights users on 6/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 8/269:49 am
PWM
- STL
2 stops13h 11m
United Airlines
Sat 8/298:00 am
STL
- PWM
1 stop5h 34m
United Airlines
Deal found 6/11![United Airlines logo]()
$399
This United Airlines deal was found by Cheapflights users on 6/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 8/186:53 pm
PWM
- STL
1 stop5h 45m
United Airlines
Wed 8/196:00 am
STL
- PWM
2 stops7h 38m
United Airlines
Deal found 6/8![United Airlines logo]()
$399
This Southwest deal was found by Cheapflights users on 6/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 11/1311:10 am
PWM
- STL
2 stops9h 05m
Southwest
Sun 11/156:40 am
STL
- PWM
1 stop5h 25m
Southwest
Deal found 6/9![Southwest logo]()
$413
This United Airlines deal was found by Cheapflights users on 6/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 6/275:00 pm
PWM
- STL
1 stop5h 26m
United Airlines
Tue 6/306:00 am
STL
- PWM
1 stop7h 31m
United Airlines
Deal found 6/10![United Airlines logo]()
$423
This Southwest deal was found by Cheapflights users on 6/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 10/2610:30 am
PWM
- STL
2 stops9h 20m
Southwest
Mon 11/22:45 pm
STL
- PWM
2 stops8h 05m
Southwest
Deal found 6/8![Southwest logo]()
$437
Last-minute flights from Portland to St. LouisDiscover last-minute flight deals from Portland to St. Louis. Data last updated June 12, 2026 and is based on user searches.
Discover last-minute flight deals from Portland to St. Louis. Data last updated June 12, 2026 and is based on user searches.
This United Airlines deal was found by Cheapflights users on 6/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 6/275:00 pm
PWM
- STL
1 stop5h 26m
United Airlines
Tue 6/306:00 am
STL
- PWM
1 stop7h 31m
United Airlines
Deal found 6/10![United Airlines logo]()
$423
This Southwest deal was found by Cheapflights users on 6/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 7/75:30 am
PWM
- STL
1 stop7h 00m
Southwest
Tue 7/144:00 pm
STL
- PWM
1 stop4h 35m
Southwest
Deal found 6/9![Southwest logo]()
$339
This Southwest deal was found by Cheapflights users on 6/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 7/75:30 am
PWM
- STL
1 stop7h 00m
Southwest
Mon 7/133:35 pm
STL
- PWM
1 stop5h 40m
Southwest
Deal found 6/8![Southwest logo]()
$383
This Southwest deal was found by Cheapflights users on 6/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 7/75:30 am
PWM
- STL
1 stop7h 00m
Southwest
Thu 7/94:25 pm
STL
- PWM
2 stops6h 45m
Southwest
Deal found 6/10![Southwest logo]()
$398
This Delta deal was found by Cheapflights users on 6/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 7/226:59 pm
PWM
- STL
1 stop5h 54m
Delta
Sat 7/253:39 pm
STL
- PWM
1 stop6h 35m
Delta
Deal found 6/10![Delta logo]()
$393
This American Airlines deal was found by Cheapflights users on 6/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 7/221:25 pm
PWM
- STL
1 stop8h 30m
American Airlines
Sat 7/255:19 pm
STL
- PWM
1 stop5h 15m
American Airlines
Deal found 6/9![American Airlines logo]()
$415
This Southwest deal was found by Cheapflights users on 6/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 7/227:10 pm
PWM
- STL
1 stop4h 55m
Southwest
Mon 7/274:35 pm
STL
- PWM
2 stops6h 35m
Southwest
Deal found 6/8![Southwest logo]()
$432
This American Airlines deal was found by Cheapflights users on 6/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 7/287:24 pm
PWM
- STL
1 stop5h 52m
American Airlines
Sun 8/26:14 am
STL
- PWM
1 stop7h 02m
American Airlines
Deal found 6/11![American Airlines logo]()
$412
One-way flights from Portland to St. LouisSearch for one-way flight options from Portland to St. Louis. Find affordable one-way fares based on user searches. Data last updated June 12, 2026.
Search for one-way flight options from Portland to St. Louis. Find affordable one-way fares based on user searches. Data last updated June 12, 2026.
This United Airlines deal was found by Cheapflights users on 6/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 8/56:00 am
PWM
- STL
1 stop7h 11m
United Airlines
Deal found 6/10![United Airlines logo]()
$138
This Southwest deal was found by Cheapflights users on 6/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 7/215:30 am
PWM
- STL
1 stop7h 00m
Southwest
Deal found 6/12![Southwest logo]()
$167
This American Airlines deal was found by Cheapflights users on 6/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 7/15:04 pm
PWM
- STL
1 stop5h 25m
American Airlines
Deal found 6/11![American Airlines logo]()
$170
This Kiwi.com deal was found by Cheapflights users on 6/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 7/15:01 pm
PWM
- STL
2 stops25h 29m
Multiple Airlines
Deal found 6/11![Multiple Airlines logo]()
$175
This Kiwi.com deal was found by Cheapflights users on 6/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 7/28:22 pm
PWM
- STL
2 stops37h 30m
Multiple Airlines
Deal found 6/8![Multiple Airlines logo]()
$178
This Kiwi.com deal was found by Cheapflights users on 6/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 7/247:00 am
PWM
- STL
2 stops26h 57m
Multiple Airlines
Deal found 6/7![Multiple Airlines logo]()
$199
This American Airlines deal was found by Cheapflights users on 6/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 7/235:18 pm
PWM
- STL
1 stop5h 03m
American Airlines
Deal found 6/7![American Airlines logo]()
$213
This American Airlines deal was found by Cheapflights users on 6/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 7/86:59 pm
PWM
- STL
1 stop5h 33m
American Airlines
Deal found 6/8![American Airlines logo]()
$214
This Southwest deal was found by Cheapflights users on 6/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 7/85:30 am
PWM
- STL
2 stops8h 35m
Southwest
Deal found 6/8![Southwest logo]()
$219
This United Airlines deal was found by Cheapflights users on 6/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 7/56:00 am
PWM
- STL
1 stop7h 11m
United Airlines
Deal found 6/8![United Airlines logo]()
$224
This United Airlines deal was found by Cheapflights users on 6/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 7/15:15 am
PWM
- STL
3 stops11h 31m
United Airlines
Deal found 6/11![United Airlines logo]()
$225
Find flight deals from Portland to St. Louis
Discover tips and strategies to find the most affordable flight options for your journey from Portland (PWM) to St. Louis (STL). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated June 12, 2026.
Most accurate provider | FlightHub 3 stars |
|---|---|
Most trusted provider | FlightHub 3 stars |
Round-trip from | $275 (American Airlines) |
One-way from | $138 (United Airlines) |
Popular in | June |
Cheapest in | September |
Average price | $727 |
Cheapflights Fare Finder
Customize your flight search to find flights from Portland to St. Louis that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated June 12, 2026.
Use the filters below to find and compare flights from Portland to St. Louis that are best for you.
Fly from
Fly to
Route
Depart
Return
Cheapest round-trip
Quickest round-trip
PortlandSt. Louis
PWM - STL
PWMSTL
Portland
Tue 7/7
5:30 am-11:30 am
1 stop7h 00m
Lambert-St Louis
Tue 7/14
4:00 pm-9:35 pm
1 stop4h 35m
$339
PortlandSt. Louis
PWM - STL
PWMSTL
Portland
Tue 7/7
5:30 am-11:30 am
1 stop7h 00m
Lambert-St Louis
Mon 7/13
5:20 pm-12:10 am
1 stop5h 50m
$383
PortlandSt. Louis
PWM - STL
PWMSTL
Portland
Wed 8/5
5:15 am-12:11 pm
2 stops7h 56m
Lambert-St Louis
Sun 8/9
6:01 am-1:25 pm
1 stop6h 24m
$385
PortlandSt. Louis
PWM - STL
PWMSTL
Portland
Wed 8/26
9:49 am-10:00 pm
2 stops13h 11m
Lambert-St Louis
Sat 8/29
8:00 am-2:34 pm
1 stop5h 34m
$399
PortlandSt. Louis
PWM - STL
PWMSTL
Portland
Tue 8/18
6:53 pm-11:38 pm
1 stop5h 45m
Lambert-St Louis
Wed 8/19
6:00 am-2:38 pm
2 stops7h 38m
$399
PortlandSt. Louis
PWM - STL
PWMSTL
Portland
Fri 11/13
11:10 am-7:15 pm
2 stops9h 05m
Lambert-St Louis
Sun 11/15
6:40 am-1:05 pm
1 stop5h 25m
$413
PortlandSt. Louis
PWM - STL
PWMSTL
Portland
Sat 6/27
5:00 pm-9:26 pm
1 stop5h 26m
Lambert-St Louis
Tue 6/30
6:00 am-2:31 pm
1 stop7h 31m
$423
PortlandSt. Louis
PWM - STL
PWMSTL
Portland
Wed 7/22
1:12 pm-8:35 pm
1 stop8h 23m
Lambert-St Louis
Sat 7/25
6:30 am-11:55 am
1 stop4h 25m
$427
PortlandSt. Louis
PWM - STL
PWMSTL
Portland
Mon 10/26
10:30 am-6:50 pm
2 stops9h 20m
Lambert-St Louis
Mon 11/2
2:45 pm-11:50 pm
2 stops8h 05m
$437
Cheapest one-way
PortlandSt. Louis
PWM - STL
PWMSTL
Portland
Tue 7/21
5:30 am-11:30 am
1 stop7h 00m
$167
Showing 1-10 of 19 resultsSorted by cheapest first
Compare providers for flights from Portland to St. Louis
Provider information is updated monthly. Please note that these providers often have deals for this flight, but the availability may vary on a day-by-day basis on Cheapflights.
Use the table below to compare price accuracy, trust ratings, and cancellation policies for each provider offering flight deals from Portland to St. Louis in June.
| Provider | Price Accuracy | Trust Score* |
|---|---|---|
| Price Accuracy1 star | Trust Score*3 stars | |
| Price Accuracy3 stars | Trust Score*3 stars |
- Most accurate provider: When it comes to deals on Portland, Maine-St. Louis flights, users find the pricing of FlightHub to be most consistent on Cheapflights vs. FlightHub Users can find the same prices on Portland, Maine-St. Louis flight deals on Cheapflights vs. FlightHub >95% of the time. Price accuracy is based on data collected from Portland, Maine-St. Louis flight searches over the past month and is updated monthly.
- Most trusted provider: When it comes to deals on Portland, Maine-St. Louis flights, Cheapflights users trust FlightHub the most. FlightHub has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for Portland, Maine-St. Louis flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.
Best time to book a flight from Portland to St. Louis
Have a flexible travel schedule? Discover the best time to fly to St. Louis from Portland with our price prediction graph.
PWM-STL
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.
Cheapflights Insights
Everything you need to know about your flight from Portland to St. Louis
What is the cheapest month to book a flight from Portland, Maine to St. Louis?
Currently, September is the cheapest month in which you can book a flight from Portland, Maine to St. Louis (average of $333). Flying from Portland, Maine to St. Louis in June is currently the most expensive (average of $727). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.
How much does it cost to fly round-trip from Portland, Maine to St. Louis?
Reviews of airlines servicing St. Louis
Get insights into the airlines that provide service to St. Louis. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to St. Louis. Reviews last updated June 12, 2026.
Get a feel of what it's like to fly with Southwest,Delta, andAmerican Airlines from Portland to St. Louis by reading reviews from past customers. Users have also rated airlines in terms of entertainment options, comfort, food, crew/service, and boarding process.
Crew
8.6
Entertainment
7.5
Overall
7.9
Boarding
8.1
Comfort
8.0
Food
7.0
Reviews
1 / 20
8.0
ExcellentLa Tracimeldamarcos,Jun 2026
LAX - SLC
Crew
8.6
Entertainment
7.5
Overall
7.9
Boarding
8.1
Comfort
8.0
Food
7.0
Reviews
1 / 20
8.0
ExcellentLa Tracimeldamarcos,Jun 2026
LAX - SLC
Crew
8.6
Entertainment
7.5
Overall
7.9
Boarding
8.1
Comfort
8.0
Food
7.0
Reviews
1 / 20
8.0
ExcellentLa Tracimeldamarcos,Jun 2026
LAX - SLC
Crew
8.6
Entertainment
7.5
Overall
7.9
Boarding
8.1
Comfort
8.0
Food
7.0
Reviews
1 / 20
8.0
ExcellentLa Tracimeldamarcos,Jun 2026
LAX - SLC
Related info for your journey
Find useful and relevant information for your journey from Portland to St. Louis. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.
Traveling to a place near St. Louis?
Book flights to St. Louis if you plan to visit one of these locationsEdwardsville
O'Fallon
Fenton
Swansea
Fairview Heights
Eureka
Maryland Heights
Collinsville
Wentzville
Glencoe
Chesterfield
Alton
Farmington
Browse thousands of different options on Cheapflights for your next trip
Toggle through the tabs below to find thousands of options on Cheapflights for your next trip.
Alternative routes
Complete your trip
Flights by cabin class
Other flight options
Other flights from Portland
Popular flights
St. Louis flight routes
Alternative routes for Portland to St. Louis
See prices for flight routes from nearby airports that may be better suited for you.
Complete your trip
Complete your trip to St. Louis by adding a car rental and/or hotel reservation to your travel itinerary.
Search flights from Portland to St. Louis by cabin class
Find flights from Portland to St. Louis, based on your preferred cabin class, be it economy, premium economy, business, or first class.
Portland and St. Louis flights
Browse other Portland and St. Louis flight options. Last updated on June 12, 2026.
Other flights from Portland
Browse through other flights departing from Portland. Flights are based on user searches made on Cheapflights and were last updated on June 12, 2026.
Popular flight searches
Check out other popular destinations found by fellow travelers in 2026
Other flights to St. Louis
Explore flights to St. Louis departing from other origins. Flights are based on user searches made on Cheapflights and were last updated on June 12, 2026.
Top 3 airlines flying from Portland to St. Louis
Discover the top 3 airlines that operate flights from Portland to St. Louis. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated June 12, 2026.
| Airline | Cheapest | Average | Flexibility | On-time |
|---|---|---|---|---|
| Cheapest$236 | Average$386 | FlexibilityNo cancel fee | On-timeN/A | |
| Cheapest$275 | Average$451 | FlexibilityNo cancel fee | On-time71% | |
| Cheapest$348 | Average$549 | FlexibilityNo cancel fee | On-time63% |