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Missouri

$126+ Cheap flights from Portland, ME (PWM) to Missouri

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 6/9. Fares are subject to change and may not be available on all flights or dates of travel.
PWM — STL
Jun 3 — Jun 101
Wed 6/3
Wed 6/10
1 adult, Economy
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Cheap flight deals from Portland to Missouri

Cheapest flights from Portland to Missouri
Explore the most affordable flight options available from Portland to Missouri. Find the lowest fares from popular airlines and budget airlines, with prices last updated on May 4, 2026.

This Kiwi.com deal was found by Cheapflights users on 5/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 5/239:52 am
PWM
-
STL
1 stop15h 05m
Multiple Airlines
Wed 5/275:27 pm
STL
-
PWM
2 stops24h 49m
Multiple Airlines
Deal found 5/2$283
This United Airlines deal was found by Cheapflights users on 5/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 5/236:00 am
PWM
-
STL
1 stop5h 34m
United Airlines
Wed 5/276:00 am
STL
-
PWM
1 stop7h 26m
United Airlines
Deal found 5/2$315
This American Airlines deal was found by Cheapflights users on 4/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 5/285:57 pm
PWM
-
MCI
1 stop6h 00m
American Airlines
Tue 6/25:21 pm
MCI
-
PWM
1 stop5h 30m
American Airlines
Deal found 4/29$340
This American Airlines deal was found by Cheapflights users on 5/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 5/296:00 am
PWM
-
STL
1 stop8h 15m
American Airlines
Tue 6/29:24 am
STL
-
PWM
1 stop6h 43m
American Airlines
Deal found 5/2$349
This Southwest deal was found by Cheapflights users on 5/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 8/115:45 am
PWM
-
STL
1 stop5h 20m
Southwest
Tue 8/1112:50 pm
STL
-
PWM
2 stops7h 20m
Southwest
Deal found 5/3$354
This American Airlines deal was found by Cheapflights users on 5/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 5/2812:19 pm
PWM
-
SGF
1 stop7h 50m
American Airlines
Sat 6/61:19 pm
SGF
-
PWM
1 stop8h 24m
American Airlines
Deal found 5/2$354
This American Airlines deal was found by Cheapflights users on 4/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 6/101:36 pm
PWM
-
STL
1 stop8h 16m
American Airlines
Mon 6/156:00 am
STL
-
PWM
1 stop5h 39m
American Airlines
Deal found 4/29$363
This American Airlines deal was found by Cheapflights users on 5/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 6/47:58 am
PWM
-
MCI
1 stop5h 49m
American Airlines
Mon 6/81:35 pm
MCI
-
PWM
1 stop7h 11m
American Airlines
Deal found 5/1$367
This United Airlines deal was found by Cheapflights users on 4/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 5/246:00 am
PWM
-
SGF
1 stop5h 42m
United Airlines
Sat 5/303:07 pm
SGF
-
PWM
1 stop5h 44m
United Airlines
Deal found 4/30$369
This Kiwi.com deal was found by Cheapflights users on 5/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 6/13:51 pm
PWM
-
STL
2 stops42h 04m
Multiple Airlines
Sun 6/74:19 pm
STL
-
PWM
1 stop15h 53m
Multiple Airlines
Deal found 5/3$371
This American Airlines deal was found by Cheapflights users on 5/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 6/16:54 pm
PWM
-
STL
1 stop6h 05m
American Airlines
Sun 6/76:00 am
STL
-
PWM
1 stop5h 39m
American Airlines
Deal found 5/3$379
This American Airlines deal was found by Cheapflights users on 4/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 6/255:58 pm
PWM
-
MCI
1 stop5h 58m
American Airlines
Tue 6/307:35 am
MCI
-
PWM
1 stop5h 49m
American Airlines
Deal found 4/30$380

Find flight deals from Portland to Missouri

Keep the following information in mind while searching for Portland to Missouri flight deals. Data was last updated May 4, 2026.

Most accurate provider

FlightHub
3 stars

Most trusted provider

FlightHub
3 stars

Round-trip from

$283
(Kiwi.com)

One-way from

$126
(Kiwi.com)

Popular in

June

Cheapest in

September

Average price

$407
Provider with most accurate pricing for Portland-Lambert-St Louis flight deals.
Search Deals
Provider most trusted by Cheapflights users for Portland-Lambert-St Louis flights.
Search Deals
From Portland to Missouri
Search Deals
One-way flight from Portland to Missouri
Search Deals
Highest demand for flights based on searches. 11% potential increase in price ($57 potential increase over avg. RT price).
Search Deals
Cheapest flight prices on average. 5% potential price decrease ($24 potential savings vs. average RT price).
Search Deals
Average for round-trip flights in May 2026
Search Deals

Cheapflights Fare Finder

 
Customize your flight search to find flights from Portland to Missouri that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated May 4, 2026.
Use the filters below to find and compare flights from Portland to Missouri that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Cheapest round-trip

PortlandSt. Louis

PWM - STL

PWMSTL

Portland

Tue 8/11

5:45 am-10:05 am

1 stop5h 20m

Lambert-St Louis

Tue 8/11

3:45 pm-10:05 pm

1 stop5h 20m

$349

PortlandSpringfield

PWM - SGF

PWMSGF

Portland

Sun 5/24

6:00 am-10:42 am

1 stop5h 42m

Springfield-Branson

Sat 5/30

3:07 pm-9:51 pm

1 stop5h 44m

$369

PortlandSpringfield

PWM - SGF

PWMSGF

Portland

Sat 6/6

5:26 am-12:47 pm

1 stop8h 21m

Springfield-Branson

Sat 6/13

1:19 pm-10:43 pm

1 stop8h 24m

$391

PortlandSpringfield

PWM - SGF

PWMSGF

Portland

Fri 5/29

6:00 am-10:42 am

1 stop5h 42m

Springfield-Branson

Sat 6/6

3:07 pm-9:51 pm

1 stop5h 44m

$406

PortlandSt. Louis

PWM - STL

PWMSTL

Portland

Sat 5/23

6:00 am-12:07 pm

1 stop7h 07m

Lambert-St Louis

Wed 5/27

11:25 am-11:30 pm

2 stops11h 05m

$410

PortlandSt. Louis

PWM - STL

PWMSTL

Portland

Wed 6/3

5:15 am-3:46 pm

2 stops11h 31m

Lambert-St Louis

Sat 6/6

1:13 pm-9:51 pm

1 stop7h 38m

$410
Quickest round-trip

PortlandSt. Louis

PWM - STL

PWMSTL

Portland

Mon 7/13

5:18 pm-9:21 pm

1 stop5h 03m

Lambert-St Louis

Tue 7/21

6:43 am-12:11 pm

1 stop4h 28m

$413

PortlandSt. Louis

PWM - STL

PWMSTL

Portland

Fri 9/18

6:00 am-12:53 pm

1 stop7h 53m

Lambert-St Louis

Sun 9/20

3:42 pm-10:33 pm

1 stop5h 51m

$427

PortlandSpringfield

PWM - SGF

PWMSGF

Portland

Fri 5/29

6:00 am-11:27 am

1 stop6h 27m

Springfield-Branson

Sat 6/6

12:07 pm-12:43 am

2 stops11h 36m

$429

PortlandSt. Louis

PWM - STL

PWMSTL

Portland

Thu 7/30

5:35 am-12:40 pm

2 stops8h 05m

Lambert-St Louis

Fri 7/31

5:20 pm-12:05 am

1 stop5h 45m

$432

Flights are sorted by cheapest round-trip flights first.

Deals found on 5/1

Showing 1-10 of 42 resultsSorted by cheapest first
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5

Best time to book a flight from Portland to Missouri

Have a flexible travel schedule? Discover the best time to fly to Missouri from Portland with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Portland to Missouri

What is the cheapest month to book a flight from Portland, Maine to Missouri?

Currently, October is the cheapest month in which you can book a flight from Portland, Maine to Missouri (average of $142). Flying from Portland, Maine to Missouri in March is currently the most expensive (average of $328). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

How much does it cost to fly round-trip from Portland, Maine to Missouri?

Reviews of airlines servicing Missouri

Get insights into the airlines that provide service to Missouri. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Missouri. Reviews last updated May 4, 2026.
See what other customers who have flown with Southwest,Delta, andUnited Airlines from Portland to Missouri have to say. Users can see the overall rating for each airline as well as how each is rated in terms of entertainment options, comfort, food, crew/service, and boarding process.
Southwest
7.9
Good
4,307 reviews

Entertainment

7.5

Crew

8.6

Food

7.0

Boarding

8.1

Overall

7.9

Comfort

8.0

Reviews

1 / 20
2.0
Mediocre

Dominic,Mar 2026

MCO - SMF

I had to try and sleep on the floor of the Austin airport. I spent 12 hours there. The airline policies were so poor, that a near violent argument broke out between the people in front of me and the flight attendants - making for a super stressful situation at 30,000 feet. Garbage airline choice by Kayak Garbage idea to book a flight with a layover. Next time I will pay for a quality booking myself, and somehow force the company to reimburse it.
Southwest
7.9
Good
4,307 reviews
Southwest
7.9
Good
4,307 reviews

Entertainment

7.5

Crew

8.6

Food

7.0

Boarding

8.1

Overall

7.9

Comfort

8.0

Reviews

1 / 20
2.0
Mediocre

Dominic,Mar 2026

MCO - SMF

I had to try and sleep on the floor of the Austin airport. I spent 12 hours there. The airline policies were so poor, that a near violent argument broke out between the people in front of me and the flight attendants - making for a super stressful situation at 30,000 feet. Garbage airline choice by Kayak Garbage idea to book a flight with a layover. Next time I will pay for a quality booking myself, and somehow force the company to reimburse it.
Delta
7.9
Good
8,460 reviews
Southwest
7.9
Good
4,307 reviews

Entertainment

7.5

Crew

8.6

Food

7.0

Boarding

8.1

Overall

7.9

Comfort

8.0

Reviews

1 / 20
2.0
Mediocre

Dominic,Mar 2026

MCO - SMF

I had to try and sleep on the floor of the Austin airport. I spent 12 hours there. The airline policies were so poor, that a near violent argument broke out between the people in front of me and the flight attendants - making for a super stressful situation at 30,000 feet. Garbage airline choice by Kayak Garbage idea to book a flight with a layover. Next time I will pay for a quality booking myself, and somehow force the company to reimburse it.
United Airlines
7.4
Good
9,680 reviews
Southwest
7.9
Good
4,307 reviews

Entertainment

7.5

Crew

8.6

Food

7.0

Boarding

8.1

Overall

7.9

Comfort

8.0

Reviews

1 / 20
2.0
Mediocre

Dominic,Mar 2026

MCO - SMF

I had to try and sleep on the floor of the Austin airport. I spent 12 hours there. The airline policies were so poor, that a near violent argument broke out between the people in front of me and the flight attendants - making for a super stressful situation at 30,000 feet. Garbage airline choice by Kayak Garbage idea to book a flight with a layover. Next time I will pay for a quality booking myself, and somehow force the company to reimburse it.
American Airlines
7.1
Good
11,673 reviews
Southwest
7.9
Good
4,307 reviews

Entertainment

7.5

Crew

8.6

Food

7.0

Boarding

8.1

Overall

7.9

Comfort

8.0

Reviews

1 / 20
2.0
Mediocre

Dominic,Mar 2026

MCO - SMF

I had to try and sleep on the floor of the Austin airport. I spent 12 hours there. The airline policies were so poor, that a near violent argument broke out between the people in front of me and the flight attendants - making for a super stressful situation at 30,000 feet. Garbage airline choice by Kayak Garbage idea to book a flight with a layover. Next time I will pay for a quality booking myself, and somehow force the company to reimburse it.

Related info for your journey

Find useful and relevant information for your journey from Portland to Missouri. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airport do you fly from for flights from Portland to Missouri?

    Located just 2.9 mi from the city center, Portland (PWM) is the airport most travelers will use when flying to Missouri from Portland.

  • How long is the flight from Portland, Maine to Missouri?

    There are many flights that can get you from Portland, Maine to Missouri in 5h 20m. Fly via Southwest, United Airlines, or American Airlines to get the fastest option. Portland, Maine and Missouri are separated by a distance of 1092 mi. Both multi-stop and nonstop flights can be found to your destination and back.

  • What are the cheapest airlines to fly from Portland, Maine to Missouri one-way?

    One-way options have recently been found by users for as low as $128 on Delta. Other airlines that offer cheap prices include American Airlines from $151 and United Airlines from $158 one-way.

  • What are the most popular routes from Portland, Maine to Missouri?

    When deciding which route to take from Portland, Maine to Missouri consider Portland - Kansas City, Portland - Lambert-St Louis or Portland - Springfield-Branson as they are the most popular.

  • Can I find deals for flights from Portland to Missouri that include hotel bookings?

    Yes. In addition to deals on Portland to Missouri flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Portland to Missouri?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Portland to Missouri.

  • Can I find deals for business class flights from Portland to Missouri?

    Yes. Cheapflights offers flight deals from Portland to Missouri by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Portland, Maine to Missouri?

    Currently, October is the cheapest month in which you can book a flight from Portland, Maine to Missouri (average of $142). Flying from Portland, Maine to Missouri in March is currently the most expensive (average of $328). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

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Alternative routes for Portland to Missouri

See prices for flight routes from nearby airports that may be better suited for you.
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Top 4 airlines flying from Portland to Missouri

Discover the top 4 airlines that operate flights from Portland to Missouri. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated May 4, 2026.
AirlineCheapestAverageFlexibilityOn-time
DeltaCheapest$236Average$410FlexibilityNo cancel feeOn-timeN/A
SouthwestCheapest$237Average$437FlexibilityNo cancel feeOn-time63%
American AirlinesCheapest$243Average$464FlexibilityNo cancel feeOn-time71%
United AirlinesCheapest$328Average$483FlexibilityNo cancel feeOn-time69%

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