Missouri

$157+ Cheap flights from Portland, ME (PWM) to Missouri

PWM — STL
Sep 18 — Sep 251
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Cheap flight deals from Portland to Missouri

Cheapest flights from Portland to Missouri

Wed 10/146:00 am -
1 stop6h 16m
Wed 10/214:30 pm -
1 stop5h 01m
Deal found 8/14$313
Wed 10/215:40 am -
1 stop5h 25m
Tue 10/276:20 am -
2 stops8h 10m
Deal found 8/15$318
Fri 11/65:28 pm -
1 stop5h 41m
Mon 11/93:54 pm -
1 stop6h 39m
Deal found 8/18$331
Thu 10/225:30 pm -
1 stop7h 55m
Tue 10/276:20 am -
2 stops8h 10m
Deal found 8/15$336
Wed 10/76:00 am -
1 stop7h 13m
Sat 10/178:00 am -
1 stop5h 38m
Deal found 8/16$339
Wed 9/166:00 am -
1 stop5h 42m
Sat 9/1912:01 pm -
1 stop7h 59m
Deal found 8/19$339
Sat 9/55:40 am -
2 stops8h 45m
Tue 9/83:45 pm -
1 stop5h 25m
Deal found 8/17$344
Tue 10/1311:20 am -
1 stop7h 14m
Sat 10/176:00 am -
1 stop6h 03m
Deal found 8/18$352
Mon 10/265:20 am -
1 stop5h 45m
Sat 10/317:40 am -
2 stops8h 55m
Deal found 8/15$357
Mon 9/146:53 pm -
1 stop5h 45m
Mon 9/2112:59 pm -
1 stop7h 24m
Deal found 8/17$359
Fri 10/164:27 pm -
1 stop5h 25m
Mon 10/199:17 am -
1 stop6h 40m
Deal found 8/18$362
Wed 10/215:40 am -
2 stops8h 50m
Mon 10/264:10 pm -
2 stops6h 45m
Deal found 8/15$368

Find flight deals from Portland to Missouri

Most accurate provider

FlightHub
3 stars

Most trusted provider

FlightHub
3 stars

Round-trip from

$313
(American Airlines)

One-way from

$157
(United Airlines)

Popular in

December

Cheapest in

January

Average price

$434
Provider with most accurate pricing for Portland-Kansas City flight deals.
Provider most trusted by Cheapflights users for Portland-Kansas City flights.
From Portland to Missouri
One-way flight from Portland to Missouri
Highest demand for flights based on searches. 2% potential increase in price ($12 potential increase over avg. RT price).
Cheapest flight prices on average. 4% potential price decrease ($19 potential savings vs. average RT price).
Average for round-trip flights in August 2026

Cheapflights Fare Finder

 
Use the filters below to find and compare flights from Portland to Missouri that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Cheapest round-trip

PortlandSpringfield

PWM Portland - SGF Springfield-Branson

PWMSGF

Portland

Sun 10/11

6:01 am-10:53 am

1 stop5h 52m

Springfield-Branson

Sun 10/18

5:27 pm-11:35 pm

1 stop5h 08m

$339

PortlandSt. Louis

PWM Portland - STL Lambert-St Louis

PWMSTL

Portland

Thu 10/29

5:30 am-12:10 pm

2 stops7h 40m

Lambert-St Louis

Sat 10/31

3:15 pm-9:51 pm

1 stop5h 36m

$344

PortlandSt. Louis

PWM Portland - STL Lambert-St Louis

PWMSTL

Portland

Sat 12/12

6:00 am-11:09 am

1 stop6h 09m

Lambert-St Louis

Mon 12/14

3:15 pm-10:57 pm

2 stops6h 42m

$344

PortlandSt. Louis

PWM Portland - STL Lambert-St Louis

PWMSTL

Portland

Mon 9/14

6:53 pm-11:38 pm

1 stop5h 45m

Lambert-St Louis

Mon 9/21

12:59 pm-9:23 pm

1 stop7h 24m

$359

PortlandSt. Louis

PWM Portland - STL Lambert-St Louis

PWMSTL

Portland

Thu 10/29

5:30 pm-12:35 am

2 stops8h 05m

Lambert-St Louis

Sat 10/31

7:00 am-5:35 pm

2 stops9h 35m

$372

PortlandSpringfield

PWM Portland - SGF Springfield-Branson

PWMSGF

Portland

Tue 9/1

6:00 am-10:48 am

1 stop5h 48m

Springfield-Branson

Sat 9/12

3:03 pm-11:59 pm

2 stops7h 56m

$379

PortlandSt. Louis

PWM Portland - STL Lambert-St Louis

PWMSTL

Portland

Thu 9/10

6:00 am-10:12 am

1 stop5h 12m

Lambert-St Louis

Sun 9/13

12:59 pm-9:23 pm

1 stop7h 24m

$388

PortlandSt. Louis

PWM Portland - STL Lambert-St Louis

PWMSTL

Portland

Thu 10/15

6:00 am-12:13 pm

1 stop7h 13m

Lambert-St Louis

Sun 10/18

8:00 am-2:38 pm

1 stop5h 38m

$388

PortlandKansas City

PWM Portland - MCI Kansas City

PWMMCI

Portland

Wed 12/30

5:25 am-2:40 pm

2 stops10h 15m

Kansas City

Tue 1/5

5:25 am-2:45 pm

2 stops8h 20m

$405

PortlandKansas City

PWM Portland - MCI Kansas City

PWMMCI

Portland

Sat 11/7

5:08 pm-9:51 pm

1 stop5h 43m

Kansas City

Mon 11/9

11:33 am-11:21 pm

2 stops10h 48m

$408

Flights are sorted by cheapest round-trip flights first.

Deals found on 8/17

Showing 1-10 of 37 resultsSorted by cheapest first
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Best time to book a flight from Portland to Missouri

Have a flexible travel schedule? Discover the best time to fly to Missouri from Portland with our price prediction graph.
Estimated round-trip price

Cheapflights Insights

Everything you need to know about your flight from Portland to Missouri

What is the cheapest month to book a flight from Portland, Maine to Missouri?

Currently, September is the cheapest month in which you can book a flight from Portland, Maine to Missouri (average of $415). Flying from Portland, Maine to Missouri in December is currently the most expensive (average of $613). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

How much does it cost to fly round-trip from Portland, Maine to Missouri?

Airfare is below average for this route at the moment.
Portland, Maine to Missouri flights typically cost between $381 and $662 in October.
The cheapest round-trip price found within the last 5 days was $339 on United Airlines (Oct 7-Oct 17).

Reviews of airlines servicing Missouri

See what other customers who have flown with Southwest,Delta, andUnited Airlines from Portland to Missouri have to say. Users can see the overall rating for each airline as well as how each is rated in terms of entertainment options, comfort, food, crew/service, and boarding process.

Crew

8.6

Entertainment

7.5

Comfort

8.0

Food

7.0

Boarding

8.1

Overall

8.0

Reviews

1 / 20
8.0
Excellent

Libby,Jun 2026

TUS - LAS

One delay in a 2 layover flight=a good trip. The crew was great.

Crew

8.6

Entertainment

7.5

Comfort

8.0

Food

7.0

Boarding

8.1

Overall

8.0

Reviews

1 / 20
8.0
Excellent

Libby,Jun 2026

TUS - LAS

One delay in a 2 layover flight=a good trip. The crew was great.

Crew

8.6

Entertainment

7.5

Comfort

8.0

Food

7.0

Boarding

8.1

Overall

8.0

Reviews

1 / 20
8.0
Excellent

Libby,Jun 2026

TUS - LAS

One delay in a 2 layover flight=a good trip. The crew was great.

Crew

8.6

Entertainment

7.5

Comfort

8.0

Food

7.0

Boarding

8.1

Overall

8.0

Reviews

1 / 20
8.0
Excellent

Libby,Jun 2026

TUS - LAS

One delay in a 2 layover flight=a good trip. The crew was great.

Crew

8.6

Entertainment

7.5

Comfort

8.0

Food

7.0

Boarding

8.1

Overall

8.0

Reviews

1 / 20
8.0
Excellent

Libby,Jun 2026

TUS - LAS

One delay in a 2 layover flight=a good trip. The crew was great.

Related info for your journey

  • What airport do you fly from for flights from Portland to Missouri?

    Located just 2.9 mi from the city center, Portland (PWM) is the airport most travelers will use when flying to Missouri from Portland.

  • How long is the flight from Portland, Maine to Missouri?

    There are many flights that can get you from Portland, Maine to Missouri in 5h 52m. Fly via United Airlines, Delta, or Southwest to get the fastest option. Portland, Maine and Missouri are separated by a distance of 1285 mi. Both multi-stop and nonstop flights can be found to your destination and back.

  • What are the cheapest airlines to fly from Portland, Maine to Missouri one-way?

    One-way options have recently been found by users for as low as $128 on Delta. Other airlines that offer cheap prices include Southwest from $149 and American Airlines from $154 one-way.

  • What are the most popular routes from Portland, Maine to Missouri?

  • Can I find deals for flights from Portland to Missouri that include hotel bookings?

    Yes. In addition to deals on Portland to Missouri flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Portland to Missouri?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Portland to Missouri.

  • Can I find deals for business class flights from Portland to Missouri?

    Yes. Cheapflights offers flight deals from Portland to Missouri by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Portland, Maine to Missouri?

    Currently, September is the cheapest month in which you can book a flight from Portland, Maine to Missouri (average of $415). Flying from Portland, Maine to Missouri in December is currently the most expensive (average of $613). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Browse thousands of different options on Cheapflights for your next trip

Top 4 airlines flying from Portland to Missouri

AirlineCheapestAverageFlexibilityOn-time
DeltaCheapest$268Average$431FlexibilityNo cancel feeOn-timeN/A
American AirlinesCheapest$314Average$476FlexibilityNo cancel feeOn-time71%
United AirlinesCheapest$328Average$461FlexibilityNo cancel feeOn-time69%
SouthwestCheapest$348Average$536FlexibilityNo cancel feeOn-time63%

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