Spartanburg

$90+ Cheap flights from Milwaukee (MKE) to Spartanburg, SC

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 5/19. Fares are subject to change and may not be available on all flights or dates of travel.
MKE — CLT
May 18 — May 251
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Cheapflights Tip: The best prices from Milwaukee-Mitchell to Spartanburg are usually found in September or July, booked 34 days in advance, depart on a Wednesday or Tuesday and return on a Wednesday

Cheap flight deals from Milwaukee to Spartanburg

Cheapest flights from Milwaukee to Spartanburg
Explore the most affordable flight options available from Milwaukee to Spartanburg. Find the lowest fares from popular airlines and budget airlines, with prices last updated on April 18, 2026.

This Kiwi.com deal was found by Cheapflights users on 4/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 4/302:50 pm
MKE
-
CLT
1 stop18h 50m
Multiple Airlines
Sun 5/37:55 am
CLT
-
MKE
1 stop28h 31m
Multiple Airlines
Deal found 4/13$223
This Trip.com deal was found by Cheapflights users on 4/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Trip.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 5/59:56 am
MKE
-
CLT
1 stop8h 17m
Frontier
Sat 5/167:58 pm
CLT
-
MKE
1 stop14h 03m
Frontier
Deal found 4/14$235
This Trip.com deal was found by Cheapflights users on 4/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Trip.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 4/246:29 pm
MKE
-
CLT
1 stop21h 27m
Frontier
Sun 4/267:19 pm
CLT
-
MKE
1 stop17h 07m
Frontier
Deal found 4/17$240
This Trip.com deal was found by Cheapflights users on 4/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Trip.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 4/3012:21 pm
MKE
-
CLT
1 stop27h 09m
Frontier
Sun 5/37:55 am
CLT
-
MKE
1 stop28h 31m
Frontier
Deal found 4/16$258
This Kiwi.com deal was found by Cheapflights users on 4/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 4/3012:21 pm
MKE
-
CLT
1 stop21h 19m
Frontier
Mon 5/117:58 pm
CLT
-
MKE
1 stop14h 03m
Frontier
Deal found 4/17$273
This American Airlines deal was found by Cheapflights users on 4/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 6/117:00 am
MKE
-
CLT
Nonstop2h 10m
American Airlines
Thu 6/111:05 pm
CLT
-
MKE
1 stop7h 52m
American Airlines
Deal found 4/17$278
This Kiwi.com deal was found by Cheapflights users on 4/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 4/3012:21 pm
MKE
-
CLT
1 stop21h 19m
Frontier
Sat 5/28:09 pm
CLT
-
MKE
1 stop13h 29m
Frontier
Deal found 4/18$283
This Kiwi.com deal was found by Cheapflights users on 4/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 6/312:09 pm
MKE
-
CLT
2 stops23h 03m
Frontier
Wed 6/107:58 pm
CLT
-
MKE
1 stop13h 00m
Frontier
Deal found 4/14$295

Find flight deals from Milwaukee to Spartanburg

Keep the following information in mind while searching for Milwaukee to Spartanburg flight deals. Data was last updated April 18, 2026.

Most accurate provider

FlightHub
3 stars

Most trusted provider

FlightHub
3 stars

Round-trip from

$223
(Kiwi.com)

One-way from

$90
(Frontier)

Popular in

March

Cheapest in

September

Average price

$438
Provider with most accurate pricing for Milwaukee-Mitchell-Charlotte Douglas flight deals.
Provider most trusted by Cheapflights users for Milwaukee-Mitchell-Charlotte Douglas flights.
From Milwaukee-Mitchell to Spartanburg
One-way flight from Milwaukee-Mitchell to Spartanburg
Highest demand for flights based on searches. 8% potential increase in price ($39 potential increase over avg. RT price).
Cheapest flight prices on average. 1% potential price decrease ($8 potential savings vs. average RT price).
Average for round-trip flights in April 2026

Cheapflights Fare Finder

 
Customize your flight search to find flights from Milwaukee to Spartanburg that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated April 18, 2026.
Use the filters below to find and compare flights from Milwaukee to Spartanburg that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Cheapest round-trip

MilwaukeeCharlotte

MKE - CLT

MKECLT

Milwaukee-Mitchell

Sat 6/6

5:45 am-10:55 am

1 stop4h 10m

Charlotte Douglas

Wed 6/10

10:40 am-5:15 pm

2 stops7h 35m

$372

MilwaukeeCharlotte

MKE - CLT

MKECLT

Milwaukee-Mitchell

Sat 9/26

8:35 am-2:25 pm

1 stop4h 50m

Charlotte Douglas

Tue 9/29

1:30 pm-9:25 pm

2 stops8h 55m

$402

MilwaukeeCharlotte

MKE - CLT

MKECLT

Milwaukee-Mitchell

Tue 5/19

2:45 pm-9:00 pm

1 stop5h 15m

Charlotte Douglas

Thu 7/30

4:40 pm-10:55 pm

1 stop7h 15m

$409

MilwaukeeCharlotte

MKE - CLT

MKECLT

Milwaukee-Mitchell

Sat 10/3

10:30 am-5:10 pm

1 stop5h 40m

Charlotte Douglas

Sun 10/4

7:15 am-10:35 am

1 stop4h 20m

$417

MilwaukeeCharlotte

MKE - CLT

MKECLT

Milwaukee-Mitchell

Fri 10/9

5:45 am-11:04 am

1 stop4h 19m

Charlotte Douglas

Tue 10/13

5:30 am-9:22 am

1 stop4h 52m

$427

MilwaukeeCharlotte

MKE - CLT

MKECLT

Milwaukee-Mitchell

Thu 9/3

6:00 am-1:28 pm

1 stop6h 28m

Charlotte Douglas

Sun 9/6

9:31 am-12:35 pm

1 stop4h 04m

$457

MilwaukeeCharlotte

MKE - CLT

MKECLT

Milwaukee-Mitchell

Thu 5/14

5:06 am-10:28 am

1 stop4h 22m

Charlotte Douglas

Sun 5/17

1:05 pm-6:00 pm

1 stop5h 55m

$457

MilwaukeeCharlotte

MKE - CLT

MKECLT

Milwaukee-Mitchell

Fri 6/5

2:55 pm-9:59 pm

1 stop6h 04m

Charlotte Douglas

Mon 6/8

1:17 pm-4:04 pm

1 stop3h 47m

$457

MilwaukeeCharlotte

MKE - CLT

MKECLT

Milwaukee-Mitchell

Thu 6/18

5:50 am-3:25 pm

2 stops8h 35m

Charlotte Douglas

Thu 6/18

9:15 pm-12:15 am

1 stop4h 00m

$464
Quickest round-trip

MilwaukeeCharlotte

MKE - CLT

MKECLT

Milwaukee-Mitchell

Wed 4/29

6:50 am-12:03 pm

1 stop4h 13m

Charlotte Douglas

Mon 5/4

8:10 am-11:27 am

1 stop4h 17m

$480

Flights are sorted by cheapest round-trip flights first.

Deals found on 4/13

Showing 1-10 of 21 resultsSorted by cheapest first
1
2
3

Best time to book a flight from Milwaukee to Spartanburg

Have a flexible travel schedule? Discover the best time to fly to Spartanburg from Milwaukee with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Milwaukee to Spartanburg

How far ahead should I book a flight from Milwaukee to Spartanburg?

Use this chart to determine the optimal time to book a round-trip flight from Milwaukee to Spartanburg. Price data was last updated on April 10, 2026.

The price you pay for your flight from Milwaukee to Spartanburg may vary depending on when you book. For the best chance of a lower fare, look to book 34 days in advance of your trip. Fares are likely to increase a fortnight or so before your departure date.

What is the cheapest time of day to fly from MKE to SB1?

Find hourly flight availability from Milwaukee to Spartanburg. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated April 18, 2026.

One of the essential ways to save on airfare from Milwaukee to Spartanburg is to remain as flexible as possible. Flights that are in the morning tend to be the most expensive. A flight in the evening could potentially save you up to 23% on airfare.

How much does it cost to fly round-trip from Milwaukee to Spartanburg?

Reviews of airlines servicing Spartanburg

Get insights into the airlines that provide service to Spartanburg. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Spartanburg. Reviews last updated April 18, 2026.
See what other customers who have flown with Southwest,Delta, andAmerican Airlines from Milwaukee to Spartanburg have to say. You can also see how each airline compares in terms of entertainment options, comfort, food, crew/service, and boarding process.

Food

7.0

Overall

8.0

Boarding

8.1

Comfort

8.0

Entertainment

7.5

Crew

8.6

Reviews

1 / 20
2.0
Mediocre

Dominic,Mar 2026

MCO - SMF

I had to try and sleep on the floor of the Austin airport. I spent 12 hours there. The airline policies were so poor, that a near violent argument broke out between the people in front of me and the flight attendants - making for a super stressful situation at 30,000 feet. Garbage airline choice by Kayak Garbage idea to book a flight with a layover. Next time I will pay for a quality booking myself, and somehow force the company to reimburse it.

Food

7.0

Overall

8.0

Boarding

8.1

Comfort

8.0

Entertainment

7.5

Crew

8.6

Reviews

1 / 20
2.0
Mediocre

Dominic,Mar 2026

MCO - SMF

I had to try and sleep on the floor of the Austin airport. I spent 12 hours there. The airline policies were so poor, that a near violent argument broke out between the people in front of me and the flight attendants - making for a super stressful situation at 30,000 feet. Garbage airline choice by Kayak Garbage idea to book a flight with a layover. Next time I will pay for a quality booking myself, and somehow force the company to reimburse it.

Food

7.0

Overall

8.0

Boarding

8.1

Comfort

8.0

Entertainment

7.5

Crew

8.6

Reviews

1 / 20
2.0
Mediocre

Dominic,Mar 2026

MCO - SMF

I had to try and sleep on the floor of the Austin airport. I spent 12 hours there. The airline policies were so poor, that a near violent argument broke out between the people in front of me and the flight attendants - making for a super stressful situation at 30,000 feet. Garbage airline choice by Kayak Garbage idea to book a flight with a layover. Next time I will pay for a quality booking myself, and somehow force the company to reimburse it.

Food

7.0

Overall

8.0

Boarding

8.1

Comfort

8.0

Entertainment

7.5

Crew

8.6

Reviews

1 / 20
2.0
Mediocre

Dominic,Mar 2026

MCO - SMF

I had to try and sleep on the floor of the Austin airport. I spent 12 hours there. The airline policies were so poor, that a near violent argument broke out between the people in front of me and the flight attendants - making for a super stressful situation at 30,000 feet. Garbage airline choice by Kayak Garbage idea to book a flight with a layover. Next time I will pay for a quality booking myself, and somehow force the company to reimburse it.

Related info for your journey

Find useful and relevant information for your journey from Milwaukee to Spartanburg. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.
  • What airport do you fly from for flights from Milwaukee to Spartanburg?

    Milwaukee-Mitchell (MKE), located 6.4 mi from the city center, is the airport you fly out of when you book flights from Milwaukee to Spartanburg. 4 airlines have flights from Milwaukee-Mitchell to Spartanburg on a regular basis. Booking flights from Milwaukee-Mitchell to Spartanburg should not be difficult; the airport handles an average of 2 outbound flights to Spartanburg per day.

  • How popular is this Milwaukee to Spartanburg flight route?

  • How long is the flight from Milwaukee to Spartanburg?

    Southwest can get you from Milwaukee to Spartanburg in just under 3h 35m. Your travel time can differ by up to . The distance from Milwaukee to Spartanburg is about 650 mi.

  • What are the cheapest airlines to fly from Milwaukee to Spartanburg one-way?

    The cheapest airline one-way is Southwest, with whom users have recently found tickets for as low as $169. However, be on the lookout for offers from American Airlines and Delta, as they are both options that can get you from Milwaukee to Spartanburg for a low price.

  • What are the cheapest flights from Milwaukee to Spartanburg?

    While on average a flight from Milwaukee to Spartanburg is generally $371, our data shows the cheapest flight currently is $166. When looking at the most popular route, (Milwaukee-Mitchell - Charlotte Douglas), you can expect to pay $284 for that flight.

  • Can I find deals for flights from Milwaukee to Spartanburg that include hotel bookings?

    Yes. In addition to deals on Milwaukee to Spartanburg flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Milwaukee to Spartanburg?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Milwaukee to Spartanburg.

  • Can I find deals for business class flights from Milwaukee to Spartanburg?

    Yes. Cheapflights offers flight deals from Milwaukee to Spartanburg by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

See more FAQs

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Top 4 airlines flying from Milwaukee to Spartanburg

Discover the top 4 airlines that operate flights from Milwaukee to Spartanburg. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated April 18, 2026.
AirlineCheapestAverageFlexibilityOn-time
DeltaCheapest$98Average$333FlexibilityNo cancel feeOn-timeN/A
American AirlinesCheapest$203Average$364FlexibilityNo cancel feeOn-time71%
United AirlinesCheapest$227Average$342FlexibilityNo cancel feeOn-time69%
SouthwestCheapest$294Average$422FlexibilityNo cancel feeOn-time63%

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