South Carolina

$91+ Cheap flights from Cleveland (CLE) to South Carolina

CLE — CHS
Dec 9 — Dec 161
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Cheap flight deals from Cleveland to South Carolina

Cheapest flights from Cleveland to South Carolina

Sun 11/159:18 pm -
1 stop10h 55m
Mon 11/168:52 pm -
2 stops23h 11m
Deal found 11/8$191
Thu 12/35:41 pm -
1 stop14h 22m
Thu 12/106:25 pm -
2 stops30h 16m
Deal found 11/5$211
Fri 11/275:33 pm -
1 stop14h 21m
Fri 12/42:58 pm -
1 stop9h 39m
Deal found 11/7$214
Tue 12/89:10 am -
1 stop24h 18m
Thu 12/106:25 pm -
1 stop6h 12m
Deal found 11/4$220
Thu 11/198:31 pm -
1 stop11h 42m
Sat 11/215:06 pm -
1 stop7h 19m
Deal found 11/4$233
Mon 11/167:18 am -
2 stops12h 54m
Fri 11/202:42 pm -
1 stop9h 43m
Deal found 11/5$236
Sun 12/65:41 pm -
1 stop14h 22m
Sun 12/136:25 pm -
2 stops30h 31m
Deal found 11/8$238
Sat 12/58:30 am -
1 stop5h 35m
Sat 12/126:40 am -
1 stop17h 57m
Deal found 11/7$243
Sun 11/159:18 pm -
1 stop23h 43m
Thu 11/1910:13 pm -
1 stop26h 12m
Deal found 11/6$247
Tue 11/179:18 pm -
1 stop21h 56m
Sat 11/217:54 pm -
1 stop28h 31m
Deal found 11/5$250
Tue 11/179:18 pm -
2 stops22h 49m
Thu 11/194:02 pm -
1 stop7h 04m
Deal found 11/4$252
Mon 11/168:00 am -
1 stop10h 03m
Thu 11/194:40 pm -
1 stop7h 09m
Deal found 11/6$255

Find flight deals from Cleveland to South Carolina

Most accurate provider

FlightHub
3 stars

Most trusted provider

FlightHub
3 stars

Round-trip from

$173
(Kiwi.com)

One-way from

$91
(Kiwi.com)

Popular in

March

Cheapest in

April

Average price

$386
Provider with most accurate pricing for Cleveland Hopkins Intl-Myrtle Beach Intl flight deals.
Provider most trusted by Cheapflights users for Cleveland Hopkins Intl-Myrtle Beach Intl flights.
From Cleveland Hopkins Intl to South Carolina
One-way flight from Cleveland Hopkins Intl to South Carolina
High demand for flights, 3% potential price rise
Cheapest flight prices on average. 4% potential price decrease ($12 potential savings vs. average RT price).
Average for round-trip flights in November 2026

Cheapflights Fare Finder

 
Use the filters below to find and compare flights from Cleveland to South Carolina that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Cheapest round-trip

ClevelandMyrtle Beach

CLE Cleveland Hopkins Intl - MYR Myrtle Beach Intl

CLEMYR

Cleveland Hopkins Intl

Tue 12/15

9:10 am-11:44 am

2 stops26h 34m

Myrtle Beach Intl

Wed 12/31

12:00 am-12:00 am

Nonstop0h 00m

$116

ClevelandGreenville

CLE Cleveland Hopkins Intl - GSP Greenville

CLEGSP

Cleveland Hopkins Intl

Mon 11/16

7:18 am-8:12 pm

2 stops12h 54m

Greenville

Wed 12/31

12:00 am-12:00 am

Nonstop0h 00m

$118

ClevelandGreenville

CLE Cleveland Hopkins Intl - GSP Greenville

CLEGSP

Cleveland Hopkins Intl

Sat 11/21

5:33 pm-9:32 am

2 stops15h 59m

Greenville

Wed 12/31

12:00 am-12:00 am

Nonstop0h 00m

$123

ClevelandGreenville

CLE Cleveland Hopkins Intl - GSP Greenville

CLEGSP

Cleveland Hopkins Intl

Tue 11/17

9:18 pm-8:07 pm

2 stops22h 49m

Greenville

Wed 12/31

12:00 am-12:00 am

Nonstop0h 00m

$130

ClevelandCharleston

CLE Cleveland Hopkins Intl - CHS Charleston

CLECHS

Cleveland Hopkins Intl

Mon 11/30

9:31 pm-8:38 am

1 stop11h 07m

Charleston

Wed 12/31

12:00 am-12:00 am

Nonstop0h 00m

$132

ClevelandGreenville

CLE Cleveland Hopkins Intl - GSP Greenville

CLEGSP

Cleveland Hopkins Intl

Mon 1/4

5:24 pm-3:29 pm

2 stops22h 05m

Greenville

Wed 12/31

12:00 am-12:00 am

Nonstop0h 00m

$149

ClevelandGreenville

CLE Cleveland Hopkins Intl - GSP Greenville

CLEGSP

Cleveland Hopkins Intl

Sat 2/27

5:08 pm-11:58 pm

1 stop6h 50m

Greenville

Wed 12/31

12:00 am-12:00 am

Nonstop0h 00m

$152

ClevelandMyrtle Beach

CLE Cleveland Hopkins Intl - MYR Myrtle Beach Intl

CLEMYR

Cleveland Hopkins Intl

Fri 11/27

6:00 am-10:07 am

1 stop4h 07m

Myrtle Beach Intl

Wed 12/31

12:00 am-12:00 am

Nonstop0h 00m

$155

ClevelandGreenville

CLE Cleveland Hopkins Intl - GSP Greenville

CLEGSP

Cleveland Hopkins Intl

Mon 1/4

2:38 pm-6:56 pm

1 stop4h 18m

Greenville

Wed 12/31

12:00 am-12:00 am

Nonstop0h 00m

$167

ClevelandGreenville

CLE Cleveland Hopkins Intl - GSP Greenville

CLEGSP

Cleveland Hopkins Intl

Thu 5/6

2:35 pm-9:21 pm

1 stop6h 46m

Greenville

Wed 12/31

12:00 am-12:00 am

Nonstop0h 00m

$194

Flights are sorted by cheapest round-trip flights first.

Deals found on 11/4

Showing 1-10 of 60 resultsSorted by cheapest first
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Best time to book a flight from Cleveland to South Carolina

Have a flexible travel schedule? Discover the best time to fly to South Carolina from Cleveland with our price prediction graph.
Estimated round-trip price

Cheapflights Insights

Everything you need to know about your flight from Cleveland to South Carolina

What is the cheapest month to book a flight from Cleveland to South Carolina?

Currently, August is the cheapest month in which you can book a flight from Cleveland to South Carolina (average of $308). Flying from Cleveland to South Carolina in March is currently the most expensive (average of $402). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from CLE to SC?

A simple way to save on the total cost of your ticket is to fly from Cleveland to South Carolina in the afternoon. If you’re flexible enough to do this you can expect to save up to 28% on your trip compared to booking a flight at noon.

How much does it cost to fly round-trip from Cleveland to South Carolina?

Airfare is below average for this route at the moment.
Cleveland to South Carolina flights typically cost between $324 and $550 in February.
The cheapest round-trip price found within the last 5 days was $191 on Multiple Airlines (Feb 23-Mar 3).

How far ahead should I book a flight from Cleveland to South Carolina?

To ensure you get the cheapest price possible for a flight from Cleveland to South Carolina, you should look to book at least 78 days in advance of your intended travel date. The price of your flight may increase if you delay and leave booking until a week or so before departure.

Reviews of airlines servicing South Carolina

Get a feel of what it's like to fly with Southwest,Delta, andUnited Airlines from Cleveland to South Carolina by reading reviews from past customers. You can also see how each airline compares in terms of entertainment options, comfort, food, crew/service, and boarding process.

Comfort

8.0

Boarding

8.1

Entertainment

7.5

Food

7.0

Overall

8.0

Crew

8.6

Reviews

1 / 20
8.0
Excellent

Patricia,Oct 2026

DAL - TPA

I love flying southwest, Both flights were packed full full - so not room for all carry one and bags had to be checked but still good flights.

Comfort

8.0

Boarding

8.1

Entertainment

7.5

Food

7.0

Overall

8.0

Crew

8.6

Reviews

1 / 20
8.0
Excellent

Patricia,Oct 2026

DAL - TPA

I love flying southwest, Both flights were packed full full - so not room for all carry one and bags had to be checked but still good flights.

Comfort

8.0

Boarding

8.1

Entertainment

7.5

Food

7.0

Overall

8.0

Crew

8.6

Reviews

1 / 20
8.0
Excellent

Patricia,Oct 2026

DAL - TPA

I love flying southwest, Both flights were packed full full - so not room for all carry one and bags had to be checked but still good flights.

Comfort

8.0

Boarding

8.1

Entertainment

7.5

Food

7.0

Overall

8.0

Crew

8.6

Reviews

1 / 20
8.0
Excellent

Patricia,Oct 2026

DAL - TPA

I love flying southwest, Both flights were packed full full - so not room for all carry one and bags had to be checked but still good flights.

Comfort

8.0

Boarding

8.1

Entertainment

7.5

Food

7.0

Overall

8.0

Crew

8.6

Reviews

1 / 20
8.0
Excellent

Patricia,Oct 2026

DAL - TPA

I love flying southwest, Both flights were packed full full - so not room for all carry one and bags had to be checked but still good flights.

Comfort

8.0

Boarding

8.1

Entertainment

7.5

Food

7.0

Overall

8.0

Crew

8.6

Reviews

1 / 20
8.0
Excellent

Patricia,Oct 2026

DAL - TPA

I love flying southwest, Both flights were packed full full - so not room for all carry one and bags had to be checked but still good flights.

Related info for your journey

  • What airport do you fly from for flights from Cleveland to South Carolina?

    Cleveland Hopkins Intl (CLE), located 10.1 mi from the city center, is the airport you fly out of when you book flights from Cleveland to South Carolina.

  • How long is the flight from Cleveland to South Carolina?

    Departing from Cleveland to South Carolina will take you 4h 08m. Cleveland and South Carolina are separated by a distance of 450 mi. This flight may include one or multiple stops.

  • What are the cheapest airlines to fly from Cleveland to South Carolina one-way?

    For one-way options, check prices for Frontier. According to our data, you can fly for as low as $67. Users have also found prices from $108 and $108 on United Airlines and Delta, respectively.

  • What are the most popular routes from Cleveland to South Carolina?

  • Can I find deals for flights from Cleveland to South Carolina that include hotel bookings?

    Yes. In addition to deals on Cleveland to South Carolina flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Cleveland to South Carolina?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Cleveland to South Carolina.

  • Can I find deals for business class flights from Cleveland to South Carolina?

    Yes. Cheapflights offers flight deals from Cleveland to South Carolina by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Cleveland to South Carolina?

    Currently, August is the cheapest month in which you can book a flight from Cleveland to South Carolina (average of $308). Flying from Cleveland to South Carolina in March is currently the most expensive (average of $402). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Browse thousands of different options on Cheapflights for your next trip

Alternative routes for Cleveland to South Carolina

Top 5 airlines flying from Cleveland to South Carolina

AirlineCheapestAverageFlexibilityOn-time
FrontierCheapest$81Average$173FlexibilityNo cancel feeOn-time62%
DeltaCheapest$106Average$368FlexibilityNo cancel feeOn-timeN/A
United AirlinesCheapest$169Average$402FlexibilityNo cancel feeOn-time69%
American AirlinesCheapest$210Average$379FlexibilityNo cancel feeOn-time71%
SouthwestCheapest$233Average$409FlexibilityNo cancel feeOn-time63%

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