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South America

$183+ Cheap flights from Knoxville (TYS) to South America

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 9/11. Fares are subject to change and may not be available on all flights or dates of travel.
TYS — BOG
Aug 19 — Aug 261
Tue 8/19
Tue 8/26
1 adult, Economy
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Cheap flight deals from Knoxville to South America

Keep the following information in mind while searching for Knoxville to South America flight deals. Data was last updated August 14, 2025.

Round-trip from

$456
(Kiwi.com)

One-way from

$183
(Kiwi.com)
From Knoxville McGhee Tyson to South America
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One-way flight from Knoxville McGhee Tyson to South America
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Find flight deals from Knoxville to South America

Cheapest flights from Knoxville to South America
Explore the most affordable flight options available from Knoxville to South America. Find the lowest fares from popular airlines and budget airlines, with prices last updated on August 14, 2025.

This Kiwi.com deal was found by Cheapflights users on 8/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/65:38 pmTYS - CTG
1 stop19h 30mMultiple Airlines
Sat 11/152:16 pmCTG - TYS
1 stop18h 48mMultiple Airlines
Deal found 8/12$456
This American Airlines deal was found by Cheapflights users on 8/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/68:04 pmTYS - CTG
2 stops19h 10mAmerican Airlines
Sat 11/154:15 pmCTG - TYS
2 stops18h 04mAmerican Airlines
Deal found 8/12$544
This LATAM Airlines deal was found by Cheapflights users on 8/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure LATAM Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 9/231:52 pmTYS - LIM
1 stop8h 18mLATAM Airlines
Tue 10/2112:00 pmLIM - TYS
1 stop10h 07mLATAM Airlines
Deal found 8/14$584
This Delta deal was found by Cheapflights users on 8/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 12/154:00 pmTYS - LIM
2 stops14h 25mDelta
Sat 1/1712:15 amLIM - TYS
2 stops14h 51mDelta
Deal found 8/14$619
This Avianca deal was found by Cheapflights users on 8/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Avianca is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 9/237:00 amTYS - LIM
2 stops18h 35mAvianca
Mon 10/202:50 amLIM - TYS
2 stops19h 00mAvianca
Deal found 8/14$642
This Delta deal was found by Cheapflights users on 8/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 12/144:00 pmTYS - LIM
2 stops14h 25mDelta
Mon 1/1912:15 pmLIM - TYS
1 stop20h 58mDelta
Deal found 8/14$695
This Delta deal was found by Cheapflights users on 8/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 12/142:30 pmTYS - LIM
2 stops15h 55mDelta
Fri 1/1612:15 pmLIM - TYS
1 stop20h 58mDelta
Deal found 8/14$715
This deal was found by Cheapflights users on 8/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 11/269:10 amTYS - LIM
1 stop14h 45mUnited Airlines
Fri 12/51:50 amLIM - TYS
1 stop11h 59mUnited Airlines
Deal found 8/14$743
This American Airlines deal was found by Cheapflights users on 8/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 8/246:39 pmTYS - CTG
2 stops18h 46mAmerican Airlines
Sat 9/61:25 pmCTG - TYS
2 stops20h 07mAmerican Airlines
Deal found 8/12$751
This Kiwi.com deal was found by Cheapflights users on 8/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 8/153:34 pmTYS - LIM
1 stop29h 36mMultiple Airlines
Fri 9/51:15 amLIM - TYS
2 stops36h 14mMultiple Airlines
Deal found 8/12$754
This LATAM Airlines deal was found by Cheapflights users on 8/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure LATAM Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/247:11 amTYS - LIM
2 stops14h 04mLATAM Airlines
Fri 10/2411:20 pmLIM - TYS
1 stop10h 08mLATAM Airlines
Deal found 8/14$791
This United Airlines deal was found by Cheapflights users on 8/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 12/287:23 pmTYS - SCL
2 stops35h 27mUnited Airlines
Wed 1/2810:45 pmSCL - TYS
2 stops16h 33mUnited Airlines
Deal found 8/13$810

Cheapflights Fare Finder

 
Customize your flight search to find flights from Knoxville to South America that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated August 14, 2025.
Use the filters below to find and compare flights from Knoxville to South America that are best for you.

Fly from

Knoxville

Fly to

South America

Route

Depart

Return

Price

KnoxvilleCartagena

TYS - CTG

TYSCTG

Knoxville McGhee Tyson

Thu 11/6

5:38 pm-1:08 pm

1 stop19h 30m

Cartagena Rafael Nunez

Sat 11/15

2:16 pm-9:04 am

1 stop18h 48m

$456

KnoxvilleCartagena

TYS - CTG

TYSCTG

Knoxville McGhee Tyson

Thu 11/6

8:04 pm-3:14 pm

2 stops19h 10m

Cartagena Rafael Nunez

Sat 11/15

4:15 pm-10:19 am

2 stops18h 04m

$544

KnoxvilleCartagena

TYS - CTG

TYSCTG

Knoxville McGhee Tyson

Thu 1/22

7:03 am-1:00 pm

1 stop5h 57m

Cartagena Rafael Nunez

Tue 1/27

2:55 pm-9:49 pm

1 stop6h 54m

$553

KnoxvilleCartagena

TYS - CTG

TYSCTG

Knoxville McGhee Tyson

Thu 1/22

9:15 am-8:41 am

2 stops23h 26m

Cartagena Rafael Nunez

Tue 1/27

9:42 am-7:34 pm

2 stops33h 52m

$554

KnoxvilleCartagena

TYS - CTG

TYSCTG

Knoxville McGhee Tyson

Sun 2/8

8:24 pm-1:00 pm

2 stops16h 36m

Cartagena Rafael Nunez

Sat 2/14

9:05 am-9:27 pm

2 stops12h 22m

$567

KnoxvilleLima

TYS - LIM

TYSLIM

Knoxville McGhee Tyson

Tue 9/23

1:52 pm-9:10 pm

1 stop8h 18m

Lima J Chavez Intl

Tue 10/21

12:00 pm-11:07 pm

1 stop10h 07m

$584

KnoxvilleLima

TYS - LIM

TYSLIM

Knoxville McGhee Tyson

Mon 12/15

4:00 pm-6:25 am

2 stops14h 25m

Lima J Chavez Intl

Sat 1/17

12:15 am-3:06 pm

2 stops14h 51m

$619

KnoxvilleLima

TYS - LIM

TYSLIM

Knoxville McGhee Tyson

Tue 9/23

7:00 am-12:35 am

2 stops18h 35m

Lima J Chavez Intl

Mon 10/20

2:50 am-10:50 pm

2 stops19h 00m

$642

KnoxvilleLima

TYS - LIM

TYSLIM

Knoxville McGhee Tyson

Mon 12/15

4:00 pm-6:25 am

2 stops14h 25m

Lima J Chavez Intl

Wed 1/21

8:25 am-9:43 pm

2 stops13h 18m

$695

KnoxvilleLima

TYS - LIM

TYSLIM

Knoxville McGhee Tyson

Sun 12/14

4:00 pm-6:25 am

2 stops14h 25m

Lima J Chavez Intl

Thu 1/15

12:15 pm-11:44 pm

1 stop11h 29m

$695

Flights are sorted by cheapest round-trip flights first.

Deals found on 8/12

Showing 1-10 of 46 results
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Best time to book a flight from Knoxville to South America

Have a flexible travel schedule? Discover the best time to fly to South America from Knoxville with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Knoxville to South America

What is the cheapest month to book a flight from Knoxville to South America?

Currently, May is the cheapest month in which you can book a flight from Knoxville to South America (average of $359). Flying from Knoxville to South America in December is currently the most expensive (average of $664). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from TYS to SA?

Find hourly flight availability from Knoxville to South America. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated August 14, 2025.

Regardless of the time of day you decide to fly, the ticket price will remain around the same. Book flights from Knoxville to South America as you normally would.

Reviews of airlines servicing South America

Get insights into the airlines that provide service to South America. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to South America. Reviews last updated August 14, 2025.
Get a feel of what it's like to fly with Delta, LATAM Airlines, and United Airlines from Knoxville to South America by reading reviews from past customers. Users have also rated airlines in terms of entertainment options, comfort, food, crew/service, and boarding process.
Delta
8.0
Very good
7,980 reviews

Comfort

7.9

Entertainment

7.9

Boarding

8.2

Food

7.3

Overall

8.0

Crew

8.5

Reviews

1 / 20
10.0
Excellent

Kim,May 2025

PIH - SLC

This trip was fine even with delay I had plenty of time to get connection flight!
Delta
8.0
Very good
7,980 reviews
Delta
8.0
Very good
7,980 reviews

Comfort

7.9

Entertainment

7.9

Boarding

8.2

Food

7.3

Overall

8.0

Crew

8.5

Reviews

1 / 20
10.0
Excellent

Kim,May 2025

PIH - SLC

This trip was fine even with delay I had plenty of time to get connection flight!
LATAM Airlines
7.5
Good
1,840 reviews
Delta
8.0
Very good
7,980 reviews

Comfort

7.9

Entertainment

7.9

Boarding

8.2

Food

7.3

Overall

8.0

Crew

8.5

Reviews

1 / 20
10.0
Excellent

Kim,May 2025

PIH - SLC

This trip was fine even with delay I had plenty of time to get connection flight!
United Airlines
7.4
Good
8,916 reviews
Delta
8.0
Very good
7,980 reviews

Comfort

7.9

Entertainment

7.9

Boarding

8.2

Food

7.3

Overall

8.0

Crew

8.5

Reviews

1 / 20
10.0
Excellent

Kim,May 2025

PIH - SLC

This trip was fine even with delay I had plenty of time to get connection flight!
American Airlines
7.2
Good
10,000 reviews
Delta
8.0
Very good
7,980 reviews

Comfort

7.9

Entertainment

7.9

Boarding

8.2

Food

7.3

Overall

8.0

Crew

8.5

Reviews

1 / 20
10.0
Excellent

Kim,May 2025

PIH - SLC

This trip was fine even with delay I had plenty of time to get connection flight!

Related info for your journey

Find useful and relevant information for your journey from Knoxville to South America. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airport do you fly from for flights from Knoxville to South America?

    If you book a flight to South America from Knoxville, you will be flying from McGhee Tyson, which is the city’s only airport. Knoxville McGhee Tyson (TYS) is located 11.3 mi from the center of Knoxville.

  • What are the most popular routes from Knoxville to South America?

    Most travelers choose Knoxville McGhee Tyson - Cartagena Rafael Nunez, Knoxville McGhee Tyson - Santiago Arturo Merino Benitez or Knoxville McGhee Tyson - Buenos Aires Ministro Pistarini when deciding on the best route from Knoxville to South America.

  • Can I find deals for flights from Knoxville to South America that include hotel bookings?

    Yes. In addition to deals on Knoxville to South America flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Knoxville to South America?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Knoxville to South America.

  • Can I find deals for business class flights from Knoxville to South America?

    Yes. Cheapflights offers flight deals from Knoxville to South America by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Knoxville to South America?

    Currently, May is the cheapest month in which you can book a flight from Knoxville to South America (average of $359). Flying from Knoxville to South America in December is currently the most expensive (average of $664). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

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Top 3 airlines flying from Knoxville to South America

Discover the top 3 airlines that operate flights from Knoxville to South America. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated August 14, 2025.
AirlineCheapestAverageFlexibilityOn-time
American AirlinesCheapest$472Average$797FlexibilityNo cancel feeOn-time71%
LATAM AirlinesCheapest$590Average$856FlexibilityNo cancel feeOn-time81%
DeltaCheapest$608Average$771FlexibilityNo cancel feeOn-timeN/A

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