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South America

$342+ Cheap flights from Knoxville (TYS) to South America

This is the cheapest round-trip flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 8/24. Fares are subject to change and may not be available on all flights or dates of travel.
TYS — BOG
Aug 3 — Aug 101
Sun 8/3
Sun 8/10
1 adult, Economy
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Cheap flight deals from Knoxville to South America

Keep the following information in mind while searching for Knoxville to South America flight deals. Data was last updated July 29, 2025.

Round-trip from

$342
(Kiwi.com)
From Knoxville McGhee Tyson to South America
Search Deals

Find flight deals from Knoxville to South America

Cheapest flights from Knoxville to South America
Explore the most affordable flight options available from Knoxville to South America. Find the lowest fares from popular airlines and budget airlines, with prices last updated on July 29, 2025.

This Kiwi.com deal was found by Cheapflights users on 7/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 8/249:12 pmTYS - CTG
1 stop16h 16mMultiple Airlines
Sat 9/61:29 pmCTG - TYS
1 stop20h 49mMultiple Airlines
Deal found 7/28$342
This American Airlines deal was found by Cheapflights users on 7/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/105:43 pmTYS - CTG
2 stops19h 42mAmerican Airlines
Tue 9/301:25 pmCTG - TYS
1 stop9h 25mAmerican Airlines
Deal found 7/27$583
This Mytrip deal was found by Cheapflights users on 7/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 8/127:00 amTYS - LIM
3 stops39h 40mMultiple Airlines
Mon 8/252:50 amLIM - TYS
2 stops15h 34mMultiple Airlines
Deal found 7/26$723
This American Airlines deal was found by Cheapflights users on 7/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 8/127:00 amTYS - LIM
1 stop16h 25mAmerican Airlines
Tue 8/266:30 amLIM - TYS
1 stop16h 16mAmerican Airlines
Deal found 7/26$752
This Trip.com deal was found by Cheapflights users on 7/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Trip.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 8/172:17 pmTYS - SCL
1 stop16h 28mMultiple Airlines
Sat 8/2311:05 pmSCL - TYS
2 stops20h 49mMultiple Airlines
Deal found 7/27$756
This Delta deal was found by Cheapflights users on 7/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 8/125:45 amTYS - LIM
1 stop16h 25mDelta
Mon 8/2512:05 amLIM - TYS
2 stops17h 58mDelta
Deal found 7/26$767
This LATAM Airlines deal was found by Cheapflights users on 7/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure LATAM Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 8/127:10 amTYS - LIM
2 stops15h 50mLATAM Airlines
Mon 8/2512:05 amLIM - TYS
2 stops17h 58mLATAM Airlines
Deal found 7/26$771
This Delta deal was found by Cheapflights users on 7/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 8/187:16 pmTYS - SCL
1 stop11h 44mDelta
Thu 8/2112:40 amSCL - TYS
2 stops23h 08mDelta
Deal found 7/26$834
This American Airlines deal was found by Cheapflights users on 7/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 12/54:32 pmTYS - SCL
1 stop13h 18mAmerican Airlines
Sun 12/1410:15 pmSCL - TYS
2 stops18h 05mAmerican Airlines
Deal found 7/28$838
This Delta deal was found by Cheapflights users on 7/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 11/292:30 pmTYS - MVD
2 stops18h 00mDelta
Mon 12/12:25 amMVD - TYS
2 stops32h 46mDelta
Deal found 7/27$856
This LATAM Airlines deal was found by Cheapflights users on 7/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure LATAM Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 9/126:08 pmTYS - SCL
1 stop11h 52mLATAM Airlines
Fri 9/199:40 pmSCL - TYS
1 stop13h 45mLATAM Airlines
Deal found 7/29$874
This Ovago deal was found by Cheapflights users on 7/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Ovago is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 8/187:16 pmTYS - AXM
2 stops43h 47mLATAM Airlines
Mon 9/154:02 pmAXM - TYS
2 stops40h 42mLATAM Airlines
Deal found 7/27$927

Cheapflights Fare Finder

 
Customize your flight search to find flights from Knoxville to South America that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated July 29, 2025.
Use the filters below to find and compare flights from Knoxville to South America that are best for you.

Fly from

Knoxville

Fly to

South America

Route

Depart

Return

Price

KnoxvilleCartagena

TYS - CTG

TYSCTG

Knoxville McGhee Tyson

Sun 8/24

9:12 pm-12:28 pm

1 stop16h 16m

Cartagena Rafael Nunez

Sat 9/6

1:29 pm-11:18 am

1 stop20h 49m

$342

KnoxvilleCartagena

TYS - CTG

TYSCTG

Knoxville McGhee Tyson

Thu 1/22

7:03 am-3:05 pm

1 stop8h 02m

Cartagena Rafael Nunez

Tue 1/27

2:55 pm-9:49 pm

1 stop6h 54m

$553

KnoxvilleCartagena

TYS - CTG

TYSCTG

Knoxville McGhee Tyson

Thu 1/22

9:15 am-8:41 am

2 stops23h 26m

Cartagena Rafael Nunez

Tue 1/27

9:42 am-5:37 pm

2 stops31h 55m

$554

KnoxvilleCartagena

TYS - CTG

TYSCTG

Knoxville McGhee Tyson

Thu 1/22

5:30 am-2:15 pm

1 stop8h 45m

Cartagena Rafael Nunez

Mon 1/26

4:35 am-11:44 pm

2 stops19h 09m

$652

KnoxvilleLima

TYS - LIM

TYSLIM

Knoxville McGhee Tyson

Tue 8/12

7:00 am-9:40 pm

3 stops39h 40m

Lima J Chavez Intl

Mon 8/25

2:50 am-7:24 pm

2 stops15h 34m

$723

KnoxvilleLima

TYS - LIM

TYSLIM

Knoxville McGhee Tyson

Tue 8/12

7:00 am-10:25 pm

1 stop16h 25m

Lima J Chavez Intl

Tue 8/26

6:30 am-11:46 pm

1 stop16h 16m

$752

KnoxvilleSantiago

TYS - SCL

TYSSCL

Knoxville McGhee Tyson

Sun 8/17

2:17 pm-6:45 am

1 stop16h 28m

Santiago Arturo Merino Benitez

Sat 8/23

11:05 pm-7:54 pm

2 stops20h 49m

$756

KnoxvilleLima

TYS - LIM

TYSLIM

Knoxville McGhee Tyson

Tue 8/12

5:45 am-9:10 pm

1 stop16h 25m

Lima J Chavez Intl

Mon 8/25

12:05 am-7:03 pm

2 stops17h 58m

$767

KnoxvilleLima

TYS - LIM

TYSLIM

Knoxville McGhee Tyson

Tue 8/12

7:10 am-10:00 pm

2 stops15h 50m

Lima J Chavez Intl

Mon 8/25

12:05 am-7:03 pm

2 stops17h 58m

$771

KnoxvilleSantiago

TYS - SCL

TYSSCL

Knoxville McGhee Tyson

Mon 8/18

6:14 pm-7:00 am

1 stop12h 46m

Santiago Arturo Merino Benitez

Fri 8/22

8:40 pm-3:54 pm

1 stop19h 14m

$834

Flights are sorted by cheapest round-trip flights first.

Deals found on 7/28

Showing 1-10 of 31 results
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Best time to book a flight from Knoxville to South America

Have a flexible travel schedule? Discover the best time to fly to South America from Knoxville with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Knoxville to South America

What is the cheapest month to book a flight from Knoxville to South America?

Currently, May is the cheapest month in which you can book a flight from Knoxville to South America (average of $359). Flying from Knoxville to South America in December is currently the most expensive (average of $664). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from TYS to SA?

Find hourly flight availability from Knoxville to South America. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated July 29, 2025.

Regardless of the time of day you decide to fly, the ticket price will remain around the same. Book flights from Knoxville to South America as you normally would.

Reviews of airlines servicing South America

Get insights into the airlines that provide service to South America. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to South America. Reviews last updated July 29, 2025.
Get a feel of what it's like to fly with Delta, LATAM Airlines, and Copa Airlines from Knoxville to South America by reading reviews from past customers. Users have also rated airlines in terms of entertainment options, comfort, food, crew/service, and boarding process.
Delta
8.0
Very good
7,979 reviews

Crew

8.5

Overall

8.0

Food

7.3

Comfort

7.9

Entertainment

7.9

Boarding

8.2

Reviews

1 / 20
10.0
Excellent

Kim,May 2025

PIH - SLC

This trip was fine even with delay I had plenty of time to get connection flight!
Delta
8.0
Very good
7,979 reviews
Delta
8.0
Very good
7,979 reviews

Crew

8.5

Overall

8.0

Food

7.3

Comfort

7.9

Entertainment

7.9

Boarding

8.2

Reviews

1 / 20
10.0
Excellent

Kim,May 2025

PIH - SLC

This trip was fine even with delay I had plenty of time to get connection flight!
LATAM Airlines
7.5
Good
1,822 reviews
Delta
8.0
Very good
7,979 reviews

Crew

8.5

Overall

8.0

Food

7.3

Comfort

7.9

Entertainment

7.9

Boarding

8.2

Reviews

1 / 20
10.0
Excellent

Kim,May 2025

PIH - SLC

This trip was fine even with delay I had plenty of time to get connection flight!
Copa Airlines
7.5
Good
1,493 reviews
Delta
8.0
Very good
7,979 reviews

Crew

8.5

Overall

8.0

Food

7.3

Comfort

7.9

Entertainment

7.9

Boarding

8.2

Reviews

1 / 20
10.0
Excellent

Kim,May 2025

PIH - SLC

This trip was fine even with delay I had plenty of time to get connection flight!
United Airlines
7.4
Good
8,896 reviews
Delta
8.0
Very good
7,979 reviews

Crew

8.5

Overall

8.0

Food

7.3

Comfort

7.9

Entertainment

7.9

Boarding

8.2

Reviews

1 / 20
10.0
Excellent

Kim,May 2025

PIH - SLC

This trip was fine even with delay I had plenty of time to get connection flight!
American Airlines
7.2
Good
10,000 reviews
Delta
8.0
Very good
7,979 reviews

Crew

8.5

Overall

8.0

Food

7.3

Comfort

7.9

Entertainment

7.9

Boarding

8.2

Reviews

1 / 20
10.0
Excellent

Kim,May 2025

PIH - SLC

This trip was fine even with delay I had plenty of time to get connection flight!

Related info for your journey

Find useful and relevant information for your journey from Knoxville to South America. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airport do you fly from for flights from Knoxville to South America?

    If you book a flight to South America from Knoxville, you will be flying from McGhee Tyson, which is the city’s only airport. Knoxville McGhee Tyson (TYS) is located 11.3 mi from the center of Knoxville.

  • What are the cheapest airlines to fly from Knoxville to South America one-way?

    The cheapest airline one-way is LATAM Airlines, with whom users have recently found tickets for as low as $538. However, be on the lookout for offers from United Airlines and American Airlines, as they are both options that can get you from Knoxville to South America for a low price.

  • What are the most popular routes from Knoxville to South America?

    Most travelers choose Knoxville McGhee Tyson - Santiago Arturo Merino Benitez, Knoxville McGhee Tyson - Cartagena Rafael Nunez or Knoxville McGhee Tyson - Buenos Aires Ministro Pistarini when deciding on the best route from Knoxville to South America.

  • Can I find deals for flights from Knoxville to South America that include hotel bookings?

    Yes. In addition to deals on Knoxville to South America flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Knoxville to South America?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Knoxville to South America.

  • Can I find deals for business class flights from Knoxville to South America?

    Yes. Cheapflights offers flight deals from Knoxville to South America by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Knoxville to South America?

    Currently, May is the cheapest month in which you can book a flight from Knoxville to South America (average of $359). Flying from Knoxville to South America in December is currently the most expensive (average of $664). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

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Top 3 airlines flying from Knoxville to South America

Discover the top 3 airlines that operate flights from Knoxville to South America. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated July 29, 2025.
AirlineCheapestAverageFlexibilityOn-time
American AirlinesCheapest$472Average$797FlexibilityNo cancel feeOn-time71%
LATAM AirlinesCheapest$590Average$856FlexibilityNo cancel feeOn-time81%
DeltaCheapest$608Average$771FlexibilityNo cancel feeOn-timeN/A

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