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South America

$165+ Cheap flights from Knoxville (TYS) to South America

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 2/27. Fares are subject to change and may not be available on all flights or dates of travel.
TYS — BOG
Feb 13 — Feb 201
Fri 2/13
Fri 2/20
1 adult, Economy
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Cheap flight deals from Knoxville to South America

Keep the following information in mind while searching for Knoxville to South America flight deals. Data was last updated January 14, 2026.

Most accurate provider

eDreams
3 stars

Most trusted provider

eDreams
3 stars

Round-trip from

$371
(Kiwi.com)

One-way from

$165
(Kiwi.com)
Provider with most accurate pricing for Knoxville McGhee Tyson-Sao Paulo (SAO) flight deals.
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Provider most trusted by Cheapflights users for Knoxville McGhee Tyson-Sao Paulo (SAO) flights.
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From Knoxville McGhee Tyson to South America
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One-way flight from Knoxville McGhee Tyson to South America
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Find flight deals from Knoxville to South America

Cheapest flights from Knoxville to South America
Explore the most affordable flight options available from Knoxville to South America. Find the lowest fares from popular airlines and budget airlines, with prices last updated on January 14, 2026.

This Kiwi.com deal was found by Cheapflights users on 1/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 4/154:25 pm
TYS
-
CTG
1 stop20h 48m
Multiple Airlines
Tue 5/51:21 pm
CTG
-
TYS
1 stop20h 15m
Multiple Airlines
Deal found 1/13$371
This Kiwi.com deal was found by Cheapflights users on 1/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 3/89:42 pm
TYS
-
CTG
1 stop15h 28m
Multiple Airlines
Wed 3/111:21 pm
CTG
-
TYS
2 stops20h 23m
Multiple Airlines
Deal found 1/12$466
This Kiwi.com deal was found by Cheapflights users on 1/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 2/263:25 pm
TYS
-
LIM
1 stop31h 10m
Multiple Airlines
Mon 3/910:30 pm
LIM
-
TYS
1 stop10h 40m
Multiple Airlines
Deal found 1/12$509
This Kiwi.com deal was found by Cheapflights users on 1/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 3/129:43 pm
TYS
-
CTG
1 stop15h 36m
Multiple Airlines
Sun 3/151:21 pm
CTG
-
TYS
1 stop17h 47m
Multiple Airlines
Deal found 1/12$516
This Avianca deal was found by Cheapflights users on 1/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Avianca is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 4/157:00 am
TYS
-
CTG
2 stops17h 36m
Avianca
Tue 5/55:29 pm
CTG
-
TYS
2 stops16h 20m
Avianca
Deal found 1/13$526
This Avianca deal was found by Cheapflights users on 1/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Avianca is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 1/227:20 pm
TYS
-
CTG
2 stops17h 50m
Avianca
Tue 1/274:20 pm
CTG
-
TYS
2 stops18h 37m
Avianca
Deal found 1/12$532
This American Airlines deal was found by Cheapflights users on 1/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 8/58:25 pm
TYS
-
CTG
2 stops18h 45m
American Airlines
Fri 8/141:25 pm
CTG
-
TYS
1 stop9h 16m
American Airlines
Deal found 1/13$537
This American Airlines deal was found by Cheapflights users on 1/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 3/74:29 pm
TYS
-
CTG
2 stops19h 58m
American Airlines
Fri 3/131:27 pm
CTG
-
TYS
2 stops20h 53m
American Airlines
Deal found 1/12$571
This American Airlines deal was found by Cheapflights users on 1/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 3/124:15 pm
TYS
-
CTG
2 stops21h 12m
American Airlines
Sun 3/153:15 pm
CTG
-
TYS
2 stops19h 05m
American Airlines
Deal found 1/12$581
This KAYAK deal was found by Cheapflights users on 1/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure KAYAK is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 11/97:07 am
TYS
-
LIM
2 stops14h 28m
LATAM Airlines
Mon 11/2312:05 am
LIM
-
TYS
2 stops17h 08m
LATAM Airlines
Deal found 1/12$595
This American Airlines deal was found by Cheapflights users on 1/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 3/85:02 pm
TYS
-
CTG
2 stops20h 25m
American Airlines
Wed 3/111:27 pm
CTG
-
TYS
2 stops19h 43m
American Airlines
Deal found 1/12$599
This KAYAK deal was found by Cheapflights users on 1/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure KAYAK is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 9/134:00 pm
TYS
-
LIM
2 stops14h 00m
LATAM Airlines
Tue 9/2212:00 pm
LIM
-
TYS
1 stop10h 47m
LATAM Airlines
Deal found 1/11$600

Cheapflights Fare Finder

 
Customize your flight search to find flights from Knoxville to South America that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated January 14, 2026.
Use the filters below to find and compare flights from Knoxville to South America that are best for you.

Fly from

Knoxville

Fly to

South America

Route

Depart

Return

Price

KnoxvilleCartagena

TYS - CTG

TYSCTG

Knoxville McGhee Tyson

Wed 4/15

4:25 pm-12:13 pm

1 stop20h 48m

Cartagena Rafael Nunez

Tue 5/5

1:21 pm-10:36 am

1 stop20h 15m

$371

KnoxvilleCartagena

TYS - CTG

TYSCTG

Knoxville McGhee Tyson

Sun 3/8

9:42 pm-12:10 pm

1 stop15h 28m

Cartagena Rafael Nunez

Wed 3/11

1:21 pm-10:44 am

2 stops20h 23m

$466

KnoxvilleLima

TYS - LIM

TYSLIM

Knoxville McGhee Tyson

Thu 2/26

3:25 pm-10:35 pm

1 stop31h 10m

Lima J Chavez Intl

Mon 3/9

10:30 pm-10:10 am

1 stop10h 40m

$509

KnoxvilleCartagena

TYS - CTG

TYSCTG

Knoxville McGhee Tyson

Wed 4/15

7:00 am-11:36 pm

2 stops17h 36m

Cartagena Rafael Nunez

Tue 5/5

5:29 pm-10:49 am

2 stops16h 20m

$526

KnoxvilleCartagena

TYS - CTG

TYSCTG

Knoxville McGhee Tyson

Thu 3/12

6:30 am-8:06 am

2 stops26h 36m

Cartagena Rafael Nunez

Sun 3/15

1:21 pm-8:08 am

1 stop17h 47m

$562

KnoxvilleCartagena

TYS - CTG

TYSCTG

Knoxville McGhee Tyson

Sat 3/7

4:29 pm-12:27 pm

2 stops19h 58m

Cartagena Rafael Nunez

Fri 3/13

1:27 pm-11:20 am

2 stops20h 53m

$571

KnoxvilleCartagena

TYS - CTG

TYSCTG

Knoxville McGhee Tyson

Sun 3/8

6:38 pm-1:15 pm

1 stop19h 37m

Cartagena Rafael Nunez

Wed 3/11

2:30 pm-11:51 pm

1 stop8h 21m

$599

KnoxvilleCartagena

TYS - CTG

TYSCTG

Knoxville McGhee Tyson

Sat 3/7

9:03 pm-12:10 pm

1 stop15h 07m

Cartagena Rafael Nunez

Fri 3/13

1:21 pm-8:40 am

1 stop18h 19m

$599

KnoxvilleLima

TYS - LIM

TYSLIM

Knoxville McGhee Tyson

Thu 6/25

5:30 am-8:20 pm

2 stops15h 50m

Lima J Chavez Intl

Wed 7/8

12:05 am-6:17 pm

2 stops17h 12m

$605

KnoxvilleCartagena

TYS - CTG

TYSCTG

Knoxville McGhee Tyson

Sun 2/1

7:20 pm-6:40 pm

2 stops23h 20m

Cartagena Rafael Nunez

Thu 2/5

10:05 pm-10:57 am

2 stops36h 52m

$606

Flights are sorted by cheapest round-trip flights first.

Deals found on 1/12

Showing 1-10 of 45 results
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Best time to book a flight from Knoxville to South America

Have a flexible travel schedule? Discover the best time to fly to South America from Knoxville with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Knoxville to South America

What is the cheapest month to book a flight from Knoxville to South America?

Currently, August is the cheapest month in which you can book a flight from Knoxville to South America (average of $530). Flying from Knoxville to South America in January is currently the most expensive (average of $677). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

Reviews of airlines servicing South America

Get insights into the airlines that provide service to South America. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to South America. Reviews last updated January 14, 2026.
Get a feel of what it's like to fly with Delta, LATAM Airlines, and United Airlines from Knoxville to South America by reading reviews from past customers. Users have also rated airlines in terms of entertainment options, comfort, food, crew/service, and boarding process.
Delta
7.9
Good
8,039 reviews

Entertainment

7.8

Crew

8.5

Overall

7.9

Comfort

7.9

Food

7.2

Boarding

8.1

Reviews

1 / 20
6.0
Good

Jim,Nov 2025

AVL - ATL

The exit row seats without a seat in front are great for leg room but don’t have a fold out entertainment console so you’re forced to use the screen several feet in front of you (there is, at least, a remote). Best to bring a tablet loaded with entertainment or a book.
Delta
7.9
Good
8,039 reviews
Delta
7.9
Good
8,039 reviews

Entertainment

7.8

Crew

8.5

Overall

7.9

Comfort

7.9

Food

7.2

Boarding

8.1

Reviews

1 / 20
6.0
Good

Jim,Nov 2025

AVL - ATL

The exit row seats without a seat in front are great for leg room but don’t have a fold out entertainment console so you’re forced to use the screen several feet in front of you (there is, at least, a remote). Best to bring a tablet loaded with entertainment or a book.
LATAM Airlines
7.5
Good
1,904 reviews
Delta
7.9
Good
8,039 reviews

Entertainment

7.8

Crew

8.5

Overall

7.9

Comfort

7.9

Food

7.2

Boarding

8.1

Reviews

1 / 20
6.0
Good

Jim,Nov 2025

AVL - ATL

The exit row seats without a seat in front are great for leg room but don’t have a fold out entertainment console so you’re forced to use the screen several feet in front of you (there is, at least, a remote). Best to bring a tablet loaded with entertainment or a book.
United Airlines
7.4
Good
9,152 reviews
Delta
7.9
Good
8,039 reviews

Entertainment

7.8

Crew

8.5

Overall

7.9

Comfort

7.9

Food

7.2

Boarding

8.1

Reviews

1 / 20
6.0
Good

Jim,Nov 2025

AVL - ATL

The exit row seats without a seat in front are great for leg room but don’t have a fold out entertainment console so you’re forced to use the screen several feet in front of you (there is, at least, a remote). Best to bring a tablet loaded with entertainment or a book.
American Airlines
7.2
Good
11,117 reviews
Delta
7.9
Good
8,039 reviews

Entertainment

7.8

Crew

8.5

Overall

7.9

Comfort

7.9

Food

7.2

Boarding

8.1

Reviews

1 / 20
6.0
Good

Jim,Nov 2025

AVL - ATL

The exit row seats without a seat in front are great for leg room but don’t have a fold out entertainment console so you’re forced to use the screen several feet in front of you (there is, at least, a remote). Best to bring a tablet loaded with entertainment or a book.

Related info for your journey

Find useful and relevant information for your journey from Knoxville to South America. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airport do you fly from for flights from Knoxville to South America?

    If you book a flight to South America from Knoxville, you will be flying from McGhee Tyson, which is the city’s only airport. Knoxville McGhee Tyson (TYS) is located 11.3 mi from the center of Knoxville.

  • How long is the flight from Knoxville to South America?

    There are many flights that can get you from Knoxville to South America in 13h 19m. Fly via Avianca, LATAM Airlines, or United Airlines to get the fastest option. The distance between Knoxville and South America is about 2203 mi. Both multi-stop and nonstop flights can be found to your destination and back.

  • What are the most popular routes from Knoxville to South America?

    Most travelers choose Knoxville McGhee Tyson - Cartagena Rafael Nunez, Knoxville McGhee Tyson - Buenos Aires Ministro Pistarini or Knoxville McGhee Tyson - Lima J Chavez Intl when deciding on the best route from Knoxville to South America.

  • Can I find deals for flights from Knoxville to South America that include hotel bookings?

    Yes. In addition to deals on Knoxville to South America flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Knoxville to South America?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Knoxville to South America.

  • Can I find deals for business class flights from Knoxville to South America?

    Yes. Cheapflights offers flight deals from Knoxville to South America by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Knoxville to South America?

    Currently, August is the cheapest month in which you can book a flight from Knoxville to South America (average of $530). Flying from Knoxville to South America in January is currently the most expensive (average of $677). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

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Top 3 airlines flying from Knoxville to South America

Discover the top 3 airlines that operate flights from Knoxville to South America. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated January 14, 2026.
AirlineCheapestAverageFlexibilityOn-time
American AirlinesCheapest$537Average$931FlexibilityNo cancel feeOn-time71%
LATAM AirlinesCheapest$593Average$830FlexibilityNo cancel feeOn-time81%
DeltaCheapest$614Average$975FlexibilityNo cancel feeOn-timeN/A

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