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South America

$337+ Cheap flights from Knoxville (TYS) to South America

This is the cheapest round-trip flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 1/22. Fares are subject to change and may not be available on all flights or dates of travel.
TYS — BOG
Dec 26 — Jan 21
Fri 12/26
Fri 1/2
1 adult, Economy
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Find flight deals from Knoxville to South America

Cheapest flights from Knoxville to South America
Explore the most affordable flight options available from Knoxville to South America. Find the lowest fares from popular airlines and budget airlines, with prices last updated on November 26, 2025.

This Kiwi.com deal was found by Cheapflights users on 11/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/312:53 pmTYS - CTG
1 stop24h 17mMultiple Airlines
Thu 12/410:04 pmCTG - TYS
2 stops23h 45mMultiple Airlines
Deal found 11/26$501
This American Airlines deal was found by Cheapflights users on 11/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/36:00 amTYS - CTG
1 stop9h 30mAmerican Airlines
Thu 12/44:30 pmCTG - TYS
1 stop7h 27mAmerican Airlines
Deal found 11/26$832
This Mytrip deal was found by Cheapflights users on 11/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 11/292:57 pmTYS - PEI
2 stops19h 43mMultiple Airlines
Mon 12/19:58 pmPEI - TYS
3 stops36h 50mMultiple Airlines
Deal found 11/25$1,050
This Mytrip deal was found by Cheapflights users on 11/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 12/266:00 amTYS - PEI
3 stops23h 55mMultiple Airlines
Fri 1/28:20 amPEI - TYS
2 stops23h 58mMultiple Airlines
Deal found 11/26$1,235
This Priceline deal was found by Cheapflights users on 11/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Priceline is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/37:10 amTYS - CTG
2 stops16h 06mLATAM Airlines
Wed 12/34:50 amCTG - TYS
2 stops18h 38mLATAM Airlines
Deal found 11/26$1,271
This FlightHub deal was found by Cheapflights users on 11/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure FlightHub is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 11/297:06 amTYS - PEI
2 stops24h 36mLATAM Airlines
Mon 12/18:26 amPEI - TYS
2 stops32h 27mLATAM Airlines
Deal found 11/25$1,715
This American Airlines deal was found by Cheapflights users on 11/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 12/126:00 amTYS - GRU
1 stop22h 20mAmerican Airlines
Thu 1/112:15 amGRU - TYS
1 stop20h 16mAmerican Airlines
Deal found 11/24$2,198
This FlightHub deal was found by Cheapflights users on 11/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure FlightHub is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 12/127:10 amTYS - GRU
2 stops35h 10mLATAM Airlines
Fri 1/210:40 amGRU - TYS
1 stop33h 34mLATAM Airlines
Deal found 11/26$2,363
This United Airlines deal was found by Cheapflights users on 11/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 12/129:40 amTYS - GRU
1 stop22h 40mUnited Airlines
Fri 1/29:45 pmGRU - TYS
1 stop21h 15mUnited Airlines
Deal found 11/24$2,441
This Delta deal was found by Cheapflights users on 11/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 12/1211:26 amTYS - GRU
2 stops16h 49mDelta
Fri 1/24:30 pmGRU - TYS
2 stops20h 01mDelta
Deal found 11/25$2,947

Cheap flight deals from Knoxville to South America

Keep the following information in mind while searching for Knoxville to South America flight deals. Data was last updated November 26, 2025.

Most accurate provider

eDreams
3 stars

Most trusted provider

eDreams
3 stars

Round-trip from

$337
(Kiwi.com)
Provider with most accurate pricing for Knoxville McGhee Tyson-Sao Paulo (SAO) flight deals.
Search Deals
Provider most trusted by Cheapflights users for Knoxville McGhee Tyson-Sao Paulo (SAO) flights.
Search Deals
From Knoxville McGhee Tyson to South America
Search Deals

Cheapflights Fare Finder

 
Customize your flight search to find flights from Knoxville to South America that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated November 26, 2025.
Use the filters below to find and compare flights from Knoxville to South America that are best for you.

Fly from

Knoxville

Fly to

South America

Route

Depart

Return

Price

KnoxvilleCartagena

TYS - CTG

TYSCTG

Knoxville McGhee Tyson

Thu 1/22

9:29 am-1:15 pm

1 stop27h 46m

Cartagena Rafael Nunez

Sat 1/31

2:21 pm-8:39 am

1 stop18h 18m

$337

KnoxvilleCartagena

TYS - CTG

TYSCTG

Knoxville McGhee Tyson

Thu 1/22

7:20 pm-2:00 pm

2 stops18h 40m

Cartagena Rafael Nunez

Tue 1/27

6:20 pm-10:57 am

2 stops16h 37m

$489

KnoxvilleLima

TYS - LIM

TYSLIM

Knoxville McGhee Tyson

Sat 1/17

11:59 am-10:35 pm

1 stop10h 36m

Lima J Chavez Intl

Sun 1/25

11:33 pm-5:28 pm

2 stops17h 55m

$497

KnoxvilleCartagena

TYS - CTG

TYSCTG

Knoxville McGhee Tyson

Fri 1/9

6:18 pm-1:15 pm

2 stops18h 57m

Cartagena Rafael Nunez

Tue 1/13

2:21 pm-3:57 pm

1 stop25h 36m

$541

KnoxvilleLima

TYS - LIM

TYSLIM

Knoxville McGhee Tyson

Sun 2/22

6:41 pm-10:10 pm

2 stops27h 29m

Lima J Chavez Intl

Thu 2/26

8:00 am-9:04 am

2 stops25h 04m

$599

KnoxvilleLima

TYS - LIM

TYSLIM

Knoxville McGhee Tyson

Sun 2/22

2:38 pm-9:20 pm

1 stop30h 42m

Lima J Chavez Intl

Wed 2/25

12:05 am-11:52 pm

2 stops23h 47m

$600

KnoxvillePereira

TYS - PEI

TYSPEI

Knoxville McGhee Tyson

Sun 2/22

7:05 am-8:24 pm

2 stops13h 19m

Pereira Matecana

Thu 2/26

8:20 am-7:55 pm

2 stops35h 35m

$623

KnoxvilleSantiago

TYS - SCL

TYSSCL

Knoxville McGhee Tyson

Thu 3/19

12:03 pm-6:35 am

2 stops17h 32m

Santiago Arturo Merino Benitez

Mon 3/23

4:35 am-11:51 pm

2 stops20h 16m

$714

KnoxvilleSantiago

TYS - SCL

TYSSCL

Knoxville McGhee Tyson

Thu 3/19

12:03 pm-6:35 am

2 stops17h 32m

Santiago Arturo Merino Benitez

Mon 3/23

10:10 pm-6:24 pm

1 stop21h 14m

$714

KnoxvilleSantiago

TYS - SCL

TYSSCL

Knoxville McGhee Tyson

Mon 2/2

4:06 pm-7:40 am

1 stop13h 34m

Santiago Arturo Merino Benitez

Tue 2/17

11:10 pm-11:08 am

1 stop13h 58m

$714

Flights are sorted by cheapest round-trip flights first.

Deals found on 11/25

Showing 1-10 of 30 results
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Best time to book a flight from Knoxville to South America

Have a flexible travel schedule? Discover the best time to fly to South America from Knoxville with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Knoxville to South America

What is the cheapest month to book a flight from Knoxville to South America?

Currently, December is the cheapest month in which you can book a flight from Knoxville to South America (average of $512). Flying from Knoxville to South America in May is currently the most expensive (average of $624). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from TYS to SA?

Find hourly flight availability from Knoxville to South America. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated November 26, 2025.

When flying from Knoxville to South America, the time of day you fly usually plays a role in the price. Save by searching for a flight in the afternoon, which can drop the price by up to 16% versus a flight in the morning.

Reviews of airlines servicing South America

Get insights into the airlines that provide service to South America. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to South America. Reviews last updated November 26, 2025.
Get a feel of what it's like to fly with Delta, LATAM Airlines, and United Airlines from Knoxville to South America by reading reviews from past customers. Users have also rated airlines in terms of entertainment options, comfort, food, crew/service, and boarding process.
Delta
7.9
Good
7,998 reviews

Overall

7.9

Entertainment

7.9

Boarding

8.1

Crew

8.5

Comfort

7.9

Food

7.3

Reviews

1 / 20
6.0
Good

Jim,Nov 2025

AVL - ATL

The exit row seats without a seat in front are great for leg room but don’t have a fold out entertainment console so you’re forced to use the screen several feet in front of you (there is, at least, a remote). Best to bring a tablet loaded with entertainment or a book.
Delta
7.9
Good
7,998 reviews
Delta
7.9
Good
7,998 reviews

Overall

7.9

Entertainment

7.9

Boarding

8.1

Crew

8.5

Comfort

7.9

Food

7.3

Reviews

1 / 20
6.0
Good

Jim,Nov 2025

AVL - ATL

The exit row seats without a seat in front are great for leg room but don’t have a fold out entertainment console so you’re forced to use the screen several feet in front of you (there is, at least, a remote). Best to bring a tablet loaded with entertainment or a book.
LATAM Airlines
7.5
Good
1,886 reviews
Delta
7.9
Good
7,998 reviews

Overall

7.9

Entertainment

7.9

Boarding

8.1

Crew

8.5

Comfort

7.9

Food

7.3

Reviews

1 / 20
6.0
Good

Jim,Nov 2025

AVL - ATL

The exit row seats without a seat in front are great for leg room but don’t have a fold out entertainment console so you’re forced to use the screen several feet in front of you (there is, at least, a remote). Best to bring a tablet loaded with entertainment or a book.
United Airlines
7.4
Good
9,046 reviews
Delta
7.9
Good
7,998 reviews

Overall

7.9

Entertainment

7.9

Boarding

8.1

Crew

8.5

Comfort

7.9

Food

7.3

Reviews

1 / 20
6.0
Good

Jim,Nov 2025

AVL - ATL

The exit row seats without a seat in front are great for leg room but don’t have a fold out entertainment console so you’re forced to use the screen several feet in front of you (there is, at least, a remote). Best to bring a tablet loaded with entertainment or a book.
American Airlines
7.2
Good
11,038 reviews
Delta
7.9
Good
7,998 reviews

Overall

7.9

Entertainment

7.9

Boarding

8.1

Crew

8.5

Comfort

7.9

Food

7.3

Reviews

1 / 20
6.0
Good

Jim,Nov 2025

AVL - ATL

The exit row seats without a seat in front are great for leg room but don’t have a fold out entertainment console so you’re forced to use the screen several feet in front of you (there is, at least, a remote). Best to bring a tablet loaded with entertainment or a book.

Related info for your journey

Find useful and relevant information for your journey from Knoxville to South America. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airport do you fly from for flights from Knoxville to South America?

    If you book a flight to South America from Knoxville, you will be flying from McGhee Tyson, which is the city’s only airport. Knoxville McGhee Tyson (TYS) is located 11.3 mi from the center of Knoxville.

  • How long is the flight from Knoxville to South America?

    There are many flights that can get you from Knoxville to South America in 13h 19m. Fly via LATAM Airlines, United Airlines, or Delta to get the fastest option. The distance between Knoxville and South America is about 2203 mi. Both multi-stop and nonstop flights can be found to your destination and back.

  • What are the most popular routes from Knoxville to South America?

    Most travelers choose Knoxville McGhee Tyson - Cartagena Rafael Nunez, Knoxville McGhee Tyson - Sao Paulo Guarulhos Intl or Knoxville McGhee Tyson - Buenos Aires Ministro Pistarini when deciding on the best route from Knoxville to South America.

  • Can I find deals for flights from Knoxville to South America that include hotel bookings?

    Yes. In addition to deals on Knoxville to South America flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Knoxville to South America?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Knoxville to South America.

  • Can I find deals for business class flights from Knoxville to South America?

    Yes. Cheapflights offers flight deals from Knoxville to South America by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Knoxville to South America?

    Currently, December is the cheapest month in which you can book a flight from Knoxville to South America (average of $512). Flying from Knoxville to South America in May is currently the most expensive (average of $624). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

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Top 3 airlines flying from Knoxville to South America

Discover the top 3 airlines that operate flights from Knoxville to South America. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated November 26, 2025.
AirlineCheapestAverageFlexibilityOn-time
American AirlinesCheapest$511Average$864FlexibilityNo cancel feeOn-time71%
LATAM AirlinesCheapest$590Average$1,072FlexibilityNo cancel feeOn-time81%
DeltaCheapest$614Average$874FlexibilityNo cancel feeOn-timeN/A

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