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South America

$259+ Cheap flights from Knoxville (TYS) to South America

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 12/30. Fares are subject to change and may not be available on all flights or dates of travel.
TYS — BOG
نوفمبر 13 — نوفمبر 201
خ 11/13
خ 11/20
1 adult, Economy
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Find flight deals from Knoxville to South America

Cheapest flights from Knoxville to South America
Explore the most affordable flight options available from Knoxville to South America. Find the lowest fares from popular airlines and budget airlines, with prices last updated on أكتوبر 14, 2025.

This Kiwi.com deal was found by Cheapflights users on 10/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
ن 11/249:29 pmTYS - CTG
1 stop15h 56mMultiple Airlines
ر 12/32:30 pmCTG - TYS
1 stop21h 23mMultiple Airlines
Deal found 10/12$349
This Kiwi.com deal was found by Cheapflights users on 10/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
ح 11/239:26 pmTYS - CTG
1 stop15h 59mMultiple Airlines
ر 12/32:30 pmCTG - TYS
1 stop21h 23mMultiple Airlines
Deal found 10/12$357
This Kiwi.com deal was found by Cheapflights users on 10/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
ث 11/259:53 amTYS - CTG
1 stop27h 32mMultiple Airlines
خ 12/42:25 pmCTG - TYS
1 stop18h 08mMultiple Airlines
Deal found 10/12$409
This Kiwi.com deal was found by Cheapflights users on 10/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
خ 11/274:27 pmTYS - CTG
1 stop20h 58mMultiple Airlines
خ 12/42:25 pmCTG - TYS
1 stop18h 08mMultiple Airlines
Deal found 10/12$413
This Kiwi.com deal was found by Cheapflights users on 10/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
ن 11/249:29 pmTYS - CTG
1 stop15h 56mMultiple Airlines
ث 12/28:38 pmCTG - TYS
2 stops15h 25mMultiple Airlines
Deal found 10/12$416
This Kiwi.com deal was found by Cheapflights users on 10/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
ث 11/1111:24 amTYS - CTG
1 stop25h 51mMultiple Airlines
س 11/152:20 pmCTG - TYS
1 stop18h 44mMultiple Airlines
Deal found 10/14$424
This Kiwi.com deal was found by Cheapflights users on 10/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
ح 11/239:26 pmTYS - CTG
1 stop15h 59mMultiple Airlines
ث 12/22:30 pmCTG - TYS
1 stop21h 33mMultiple Airlines
Deal found 10/12$435
This Kiwi.com deal was found by Cheapflights users on 10/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
ن 11/249:29 pmTYS - CTG
1 stop15h 56mMultiple Airlines
ج 11/282:30 pmCTG - TYS
1 stop23h 37mMultiple Airlines
Deal found 10/12$463
This Kiwi.com deal was found by Cheapflights users on 10/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
ث 11/259:53 amTYS - CTG
1 stop27h 32mMultiple Airlines
ر 12/39:24 pmCTG - TYS
2 stops14h 29mMultiple Airlines
Deal found 10/12$470
This Mytrip deal was found by Cheapflights users on 10/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
ج 10/318:15 amTYS - PEI
2 stops22h 40mMultiple Airlines
ر 11/57:13 pmPEI - TYS
3 stops13h 51mMultiple Airlines
Deal found 10/14$563
This LATAM Airlines deal was found by Cheapflights users on 10/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure LATAM Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
خ 11/273:53 pmTYS - SCL
2 stops21h 37mLATAM Airlines
ر 12/34:35 amSCL - TYS
2 stops21h 15mLATAM Airlines
Deal found 10/13$714
This Delta deal was found by Cheapflights users on 10/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
س 11/295:35 amTYS - MVD
2 stops34h 25mDelta
ث 12/27:40 amMVD - TYS
2 stops18h 12mDelta
Deal found 10/13$757

Cheap flight deals from Knoxville to South America

Keep the following information in mind while searching for Knoxville to South America flight deals. Data was last updated أكتوبر 14, 2025.

Most accurate provider

FlightHub
3 stars

Most trusted provider

FlightHub
3 stars

Round-trip from

$349
(Kiwi.com)

One-way from

$266
(Kiwi.com)
Provider with most accurate pricing for Knoxville McGhee Tyson-Sao Paulo (SAO) flight deals.
Search Deals
Provider most trusted by Cheapflights users for Knoxville McGhee Tyson-Sao Paulo (SAO) flights.
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From Knoxville McGhee Tyson to South America
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One-way flight from Knoxville McGhee Tyson to South America
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Cheapflights Fare Finder

 
Customize your flight search to find flights from Knoxville to South America that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated أكتوبر 14, 2025.
Use the filters below to find and compare flights from Knoxville to South America that are best for you.

Fly from

Knoxville

Fly to

South America

Route

Depart

Return

Price

KnoxvilleCartagena

TYS - CTG

TYSCTG

Knoxville McGhee Tyson

ن 11/24

9:29 pm-1:25 pm

1 stop15h 56m

Cartagena Rafael Nunez

خ 12/4

2:25 pm-8:33 am

1 stop18h 08m

$349

KnoxvilleCartagena

TYS - CTG

TYSCTG

Knoxville McGhee Tyson

ن 11/24

9:29 pm-1:25 pm

1 stop15h 56m

Cartagena Rafael Nunez

ر 12/3

9:24 pm-11:53 am

2 stops14h 29m

$409

KnoxvilleCartagena

TYS - CTG

TYSCTG

Knoxville McGhee Tyson

ح 11/23

9:26 pm-1:25 pm

1 stop15h 59m

Cartagena Rafael Nunez

ر 12/3

9:24 pm-11:53 am

2 stops14h 29m

$417

KnoxvilleCartagena

TYS - CTG

TYSCTG

Knoxville McGhee Tyson

ث 11/11

11:24 am-1:15 pm

1 stop25h 51m

Cartagena Rafael Nunez

س 11/15

2:20 pm-9:04 am

1 stop18h 44m

$424

KnoxvilleCartagena

TYS - CTG

TYSCTG

Knoxville McGhee Tyson

ث 11/25

9:53 am-1:25 pm

1 stop27h 32m

Cartagena Rafael Nunez

ر 12/3

9:24 pm-11:53 am

2 stops14h 29m

$470

KnoxvilleCartagena

TYS - CTG

TYSCTG

Knoxville McGhee Tyson

ر 11/12

4:32 pm-6:10 am

2 stops13h 38m

Cartagena Rafael Nunez

س 11/15

2:20 pm-9:04 am

1 stop18h 44m

$477

KnoxvilleCartagena

TYS - CTG

TYSCTG

Knoxville McGhee Tyson

ث 11/25

9:53 am-1:25 pm

1 stop27h 32m

Cartagena Rafael Nunez

ث 12/2

8:38 pm-12:03 pm

2 stops15h 25m

$477

KnoxvilleCartagena

TYS - CTG

TYSCTG

Knoxville McGhee Tyson

خ 11/27

4:27 pm-1:25 pm

1 stop20h 58m

Cartagena Rafael Nunez

ث 12/2

2:30 pm-12:03 pm

1 stop21h 33m

$490

KnoxvilleCartagena

TYS - CTG

TYSCTG

Knoxville McGhee Tyson

ث 11/11

11:24 am-1:15 pm

1 stop25h 51m

Cartagena Rafael Nunez

ح 11/16

5:55 pm-6:36 pm

2 stops24h 41m

$500

KnoxvillePereira

TYS - PEI

TYSPEI

Knoxville McGhee Tyson

ج 10/31

8:15 am-5:55 am

2 stops22h 40m

Pereira Matecana

ر 11/5

7:13 pm-9:04 am

3 stops13h 51m

$563

Flights are sorted by cheapest round-trip flights first.

Deals found on 10/14

Showing 1-10 of 55 results
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Best time to book a flight from Knoxville to South America

Have a flexible travel schedule? Discover the best time to fly to South America from Knoxville with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Knoxville to South America

What is the cheapest month to book a flight from Knoxville to South America?

Currently, December is the cheapest month in which you can book a flight from Knoxville to South America (average of $512). Flying from Knoxville to South America in May is currently the most expensive (average of $624). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from TYS to SA?

Find hourly flight availability from Knoxville to South America. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated أكتوبر 14, 2025.

When flying from Knoxville to South America, the time of day you fly usually plays a role in the price. Save by searching for a flight in the afternoon, which can drop the price by up to 18% versus a flight in the morning.

Reviews of airlines servicing South America

Get insights into the airlines that provide service to South America. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to South America. Reviews last updated أكتوبر 14, 2025.
Get a feel of what it's like to fly with Delta, LATAM Airlines, and United Airlines from Knoxville to South America by reading reviews from past customers. Users have also rated airlines in terms of entertainment options, comfort, food, crew/service, and boarding process.
Delta
8.0
Very good
7,975 reviews

Crew

8.5

Boarding

8.2

Food

7.3

Entertainment

7.9

Comfort

7.9

Overall

8.0

Reviews

1 / 20
8.0
Excellent

Matthew,Oct 2025

GSP - ATL

This is always a full flight since it is the connecting route to primary destinations through Atlanta. That said, the crew handles the full load well. Not much more to say, it is a short flight with no in-flight services due to the length.
Delta
8.0
Very good
7,975 reviews
Delta
8.0
Very good
7,975 reviews

Crew

8.5

Boarding

8.2

Food

7.3

Entertainment

7.9

Comfort

7.9

Overall

8.0

Reviews

1 / 20
8.0
Excellent

Matthew,Oct 2025

GSP - ATL

This is always a full flight since it is the connecting route to primary destinations through Atlanta. That said, the crew handles the full load well. Not much more to say, it is a short flight with no in-flight services due to the length.
LATAM Airlines
7.5
Good
1,866 reviews
Delta
8.0
Very good
7,975 reviews

Crew

8.5

Boarding

8.2

Food

7.3

Entertainment

7.9

Comfort

7.9

Overall

8.0

Reviews

1 / 20
8.0
Excellent

Matthew,Oct 2025

GSP - ATL

This is always a full flight since it is the connecting route to primary destinations through Atlanta. That said, the crew handles the full load well. Not much more to say, it is a short flight with no in-flight services due to the length.
United Airlines
7.4
Good
8,976 reviews
Delta
8.0
Very good
7,975 reviews

Crew

8.5

Boarding

8.2

Food

7.3

Entertainment

7.9

Comfort

7.9

Overall

8.0

Reviews

1 / 20
8.0
Excellent

Matthew,Oct 2025

GSP - ATL

This is always a full flight since it is the connecting route to primary destinations through Atlanta. That said, the crew handles the full load well. Not much more to say, it is a short flight with no in-flight services due to the length.
American Airlines
7.2
Good
11,042 reviews
Delta
8.0
Very good
7,975 reviews

Crew

8.5

Boarding

8.2

Food

7.3

Entertainment

7.9

Comfort

7.9

Overall

8.0

Reviews

1 / 20
8.0
Excellent

Matthew,Oct 2025

GSP - ATL

This is always a full flight since it is the connecting route to primary destinations through Atlanta. That said, the crew handles the full load well. Not much more to say, it is a short flight with no in-flight services due to the length.

Related info for your journey

Find useful and relevant information for your journey from Knoxville to South America. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airport do you fly from for flights from Knoxville to South America?

    If you book a flight to South America from Knoxville, you will be flying from McGhee Tyson, which is the city’s only airport. Knoxville McGhee Tyson (TYS) is located 11.3 mi from the center of Knoxville.

  • How long is the flight from Knoxville to South America?

    There are many flights that can get you from Knoxville to South America in 13h 06m. Fly via LATAM Airlines, Delta, or American Airlines to get the fastest option. The distance between Knoxville and South America is about 4853 mi. Both multi-stop and nonstop flights can be found to your destination and back.

  • What are the most popular routes from Knoxville to South America?

    Most travelers choose Knoxville McGhee Tyson - Cartagena Rafael Nunez, Knoxville McGhee Tyson - Buenos Aires Ministro Pistarini or Knoxville McGhee Tyson - Sao Paulo Guarulhos Intl when deciding on the best route from Knoxville to South America.

  • Can I find deals for flights from Knoxville to South America that include hotel bookings?

    Yes. In addition to deals on Knoxville to South America flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Knoxville to South America?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Knoxville to South America.

  • Can I find deals for business class flights from Knoxville to South America?

    Yes. Cheapflights offers flight deals from Knoxville to South America by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Knoxville to South America?

    Currently, December is the cheapest month in which you can book a flight from Knoxville to South America (average of $512). Flying from Knoxville to South America in May is currently the most expensive (average of $624). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

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Alternative routes for Knoxville to South America

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Top 3 airlines flying from Knoxville to South America

Discover the top 3 airlines that operate flights from Knoxville to South America. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated أكتوبر 14, 2025.
AirlineCheapestAverageFlexibilityOn-time
American AirlinesCheapest$511Average$773FlexibilityNo cancel feeOn-time71%
LATAM AirlinesCheapest$590Average$1,188FlexibilityNo cancel feeOn-time81%
DeltaCheapest$614Average$777FlexibilityNo cancel feeOn-timeN/A

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