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South America

$289+ Cheap flights from Knoxville (TYS) to South America

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 3/12. Fares are subject to change and may not be available on all flights or dates of travel.
TYS — BOG
Mar 28 — Apr 41
Sat 3/28
Sat 4/4
1 adult, Economy
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Cheap flight deals from Knoxville to South America

Cheapest flights from Knoxville to South America
Explore the most affordable flight options available from Knoxville to South America. Find the lowest fares from popular airlines and budget airlines, with prices last updated on February 26, 2026.

This Kiwi.com deal was found by Cheapflights users on 2/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 5/85:39 pm
TYS
-
CTG
2 stops19h 26m
Multiple Airlines
Tue 5/121:11 pm
CTG
-
TYS
1 stop20h 25m
Multiple Airlines
Deal found 2/24$454
This American Airlines deal was found by Cheapflights users on 2/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 9/37:00 am
TYS
-
CTG
1 stop8h 10m
American Airlines
Mon 9/142:05 pm
CTG
-
TYS
2 stops21h 21m
American Airlines
Deal found 2/23$573
This Kiwi.com deal was found by Cheapflights users on 2/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 3/277:40 am
TYS
-
LIM
1 stop14h 55m
Multiple Airlines
Fri 4/34:00 am
LIM
-
TYS
2 stops18h 20m
Multiple Airlines
Deal found 2/25$577
This American Airlines deal was found by Cheapflights users on 2/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 5/86:38 pm
TYS
-
CTG
2 stops18h 31m
American Airlines
Tue 5/121:25 pm
CTG
-
TYS
2 stops20h 01m
American Airlines
Deal found 2/24$581
This Delta deal was found by Cheapflights users on 2/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 3/257:10 am
TYS
-
CTG
1 stop7h 05m
Delta
Mon 3/309:35 am
CTG
-
TYS
2 stops13h 22m
Delta
Deal found 2/23$583
This American Airlines deal was found by Cheapflights users on 2/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 3/255:00 am
TYS
-
CTG
2 stops10h 15m
American Airlines
Mon 3/303:19 pm
CTG
-
TYS
2 stops17h 34m
American Airlines
Deal found 2/23$597
This United Airlines deal was found by Cheapflights users on 2/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 9/37:00 am
TYS
-
CTG
2 stops17h 00m
United Airlines
Mon 9/143:02 pm
CTG
-
TYS
2 stops31h 17m
United Airlines
Deal found 2/24$604
This Avianca deal was found by Cheapflights users on 2/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Avianca is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 8/15:57 pm
TYS
-
PEI
2 stops16h 13m
Multiple Airlines
Sat 9/55:00 pm
PEI
-
TYS
2 stops16h 00m
Multiple Airlines
Deal found 2/24$614
This LATAM Airlines deal was found by Cheapflights users on 2/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure LATAM Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 3/247:10 am
TYS
-
LIM
2 stops15h 25m
LATAM Airlines
Tue 3/3112:05 pm
LIM
-
TYS
1 stop10h 52m
LATAM Airlines
Deal found 2/23$615
This American Airlines deal was found by Cheapflights users on 2/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 3/246:00 am
TYS
-
LIM
1 stop15h 30m
American Airlines
Tue 3/316:30 am
LIM
-
TYS
2 stops15h 18m
American Airlines
Deal found 2/23$620
This Delta deal was found by Cheapflights users on 2/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 4/25:40 am
TYS
-
LIM
2 stops16h 55m
Delta
Sat 4/188:55 am
LIM
-
TYS
2 stops13h 59m
Delta
Deal found 2/24$635
This LATAM Airlines deal was found by Cheapflights users on 2/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure LATAM Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 9/64:00 pm
TYS
-
LIM
2 stops14h 00m
LATAM Airlines
Sat 9/1212:15 am
LIM
-
TYS
2 stops17h 02m
LATAM Airlines
Deal found 2/25$640

Find flight deals from Knoxville to South America

Keep the following information in mind while searching for Knoxville to South America flight deals. Data was last updated February 26, 2026.

Round-trip from

$454
(Kiwi.com)

One-way from

$289
(Kiwi.com)
From Knoxville McGhee Tyson to South America
Search Deals
One-way flight from Knoxville McGhee Tyson to South America
Search Deals

Cheapflights Fare Finder

 
Customize your flight search to find flights from Knoxville to South America that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated February 26, 2026.
Use the filters below to find and compare flights from Knoxville to South America that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

KnoxvilleCartagena

TYS - CTG

TYSCTG

Knoxville McGhee Tyson

Fri 5/8

5:39 pm-12:05 pm

2 stops19h 26m

Cartagena Rafael Nunez

Tue 5/12

1:11 pm-10:36 am

1 stop20h 25m

$454

KnoxvilleCartagena

TYS - CTG

TYSCTG

Knoxville McGhee Tyson

Wed 3/25

7:10 am-1:15 pm

1 stop7h 05m

Cartagena Rafael Nunez

Mon 3/30

9:35 am-11:57 pm

2 stops13h 22m

$583

KnoxvillePereira

TYS - PEI

TYSPEI

Knoxville McGhee Tyson

Sat 8/1

5:57 pm-9:10 am

2 stops16h 13m

Pereira Matecana

Sat 9/5

5:00 pm-10:00 am

2 stops16h 00m

$614

KnoxvilleLima

TYS - LIM

TYSLIM

Knoxville McGhee Tyson

Tue 3/24

7:10 am-9:35 pm

2 stops15h 25m

Lima J Chavez Intl

Tue 3/31

12:05 pm-11:57 pm

1 stop10h 52m

$615

KnoxvilleLima

TYS - LIM

TYSLIM

Knoxville McGhee Tyson

Tue 3/24

6:00 am-8:30 pm

1 stop15h 30m

Lima J Chavez Intl

Tue 3/31

6:30 am-10:48 pm

2 stops15h 18m

$620

KnoxvilleLima

TYS - LIM

TYSLIM

Knoxville McGhee Tyson

Thu 4/2

5:40 am-9:35 pm

2 stops16h 55m

Lima J Chavez Intl

Sat 4/18

8:55 am-11:54 pm

2 stops13h 59m

$635

KnoxvilleLima

TYS - LIM

TYSLIM

Knoxville McGhee Tyson

Sat 4/11

5:40 am-9:35 pm

2 stops16h 55m

Lima J Chavez Intl

Fri 4/17

12:10 am-11:54 pm

2 stops22h 44m

$655

KnoxvilleLima

TYS - LIM

TYSLIM

Knoxville McGhee Tyson

Wed 4/1

8:30 am-12:55 am

2 stops17h 25m

Lima J Chavez Intl

Mon 4/6

10:35 pm-2:06 pm

1 stop14h 31m

$659

KnoxvillePereira

TYS - PEI

TYSPEI

Knoxville McGhee Tyson

Sun 4/12

7:05 am-11:35 pm

2 stops41h 30m

Pereira Matecana

Thu 4/16

5:15 am-7:56 pm

2 stops13h 41m

$700

KnoxvilleLima

TYS - LIM

TYSLIM

Knoxville McGhee Tyson

Tue 5/12

7:31 am-8:55 pm

2 stops14h 24m

Lima J Chavez Intl

Sat 5/16

12:05 pm-11:56 pm

1 stop10h 51m

$701

Flights are sorted by cheapest round-trip flights first.

Deals found on 2/24

Showing 1-10 of 45 resultsSorted by cheapest first
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Best time to book a flight from Knoxville to South America

Have a flexible travel schedule? Discover the best time to fly to South America from Knoxville with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Knoxville to South America

What is the cheapest month to book a flight from Knoxville to South America?

Currently, December is the cheapest month in which you can book a flight from Knoxville to South America (average of $525). Flying from Knoxville to South America in November is currently the most expensive (average of $674). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

Reviews of airlines servicing South America

Get insights into the airlines that provide service to South America. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to South America. Reviews last updated February 26, 2026.
Get a feel of what it's like to fly with Delta, LATAM Airlines, and American Airlines from Knoxville to South America by reading reviews from past customers. Users have also rated airlines in terms of entertainment options, comfort, food, crew/service, and boarding process.
Delta
7.9
Good
8,237 reviews

Boarding

8.1

Comfort

7.9

Crew

8.5

Overall

7.9

Food

7.2

Entertainment

7.8

Reviews

1 / 20
6.0
Good

Jim,Nov 2025

AVL - ATL

The exit row seats without a seat in front are great for leg room but don’t have a fold out entertainment console so you’re forced to use the screen several feet in front of you (there is, at least, a remote). Best to bring a tablet loaded with entertainment or a book.
Delta
7.9
Good
8,237 reviews
Delta
7.9
Good
8,237 reviews

Boarding

8.1

Comfort

7.9

Crew

8.5

Overall

7.9

Food

7.2

Entertainment

7.8

Reviews

1 / 20
6.0
Good

Jim,Nov 2025

AVL - ATL

The exit row seats without a seat in front are great for leg room but don’t have a fold out entertainment console so you’re forced to use the screen several feet in front of you (there is, at least, a remote). Best to bring a tablet loaded with entertainment or a book.
LATAM Airlines
7.5
Good
1,919 reviews
Delta
7.9
Good
8,237 reviews

Boarding

8.1

Comfort

7.9

Crew

8.5

Overall

7.9

Food

7.2

Entertainment

7.8

Reviews

1 / 20
6.0
Good

Jim,Nov 2025

AVL - ATL

The exit row seats without a seat in front are great for leg room but don’t have a fold out entertainment console so you’re forced to use the screen several feet in front of you (there is, at least, a remote). Best to bring a tablet loaded with entertainment or a book.
American Airlines
7.2
Good
11,353 reviews
Delta
7.9
Good
8,237 reviews

Boarding

8.1

Comfort

7.9

Crew

8.5

Overall

7.9

Food

7.2

Entertainment

7.8

Reviews

1 / 20
6.0
Good

Jim,Nov 2025

AVL - ATL

The exit row seats without a seat in front are great for leg room but don’t have a fold out entertainment console so you’re forced to use the screen several feet in front of you (there is, at least, a remote). Best to bring a tablet loaded with entertainment or a book.

Related info for your journey

Find useful and relevant information for your journey from Knoxville to South America. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airport do you fly from for flights from Knoxville to South America?

    If you book a flight to South America from Knoxville, you will be flying from McGhee Tyson, which is the city’s only airport. Knoxville McGhee Tyson (TYS) is located 11.3 mi from the center of Knoxville.

  • How long is the flight from Knoxville to South America?

    There are many flights that can get you from Knoxville to South America in 7h 05m. Fly via Delta, American Airlines, or United Airlines to get the fastest option. The distance between Knoxville and South America is about 1830 mi. Both multi-stop and nonstop flights can be found to your destination and back.

  • What are the most popular routes from Knoxville to South America?

    Most travelers choose Knoxville McGhee Tyson - Sao Paulo Guarulhos Intl, Knoxville McGhee Tyson - Lima J Chavez Intl or Knoxville McGhee Tyson - Pereira Matecana when deciding on the best route from Knoxville to South America.

  • Can I find deals for flights from Knoxville to South America that include hotel bookings?

    Yes. In addition to deals on Knoxville to South America flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Knoxville to South America?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Knoxville to South America.

  • Can I find deals for business class flights from Knoxville to South America?

    Yes. Cheapflights offers flight deals from Knoxville to South America by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Knoxville to South America?

    Currently, December is the cheapest month in which you can book a flight from Knoxville to South America (average of $525). Flying from Knoxville to South America in November is currently the most expensive (average of $674). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

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Top 3 airlines flying from Knoxville to South America

Discover the top 3 airlines that operate flights from Knoxville to South America. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated February 26, 2026.
AirlineCheapestAverageFlexibilityOn-time
American AirlinesCheapest$537Average$859FlexibilityNo cancel feeOn-time71%
DeltaCheapest$614Average$1,097FlexibilityNo cancel feeOn-timeN/A
LATAM AirlinesCheapest$619Average$830FlexibilityNo cancel feeOn-time81%

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