$254+ Cheap flights from North Carolina to Santiago (SCL)
This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 3/25. Fares are subject to change and may not be available on all flights or dates of travel.
RDU — SCL
Mar 5 — Mar 121
1 adult, Economy
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Find cheap flights from North Carolina to Santiago with Cheapflights
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Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”2. Select your favorite providers
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Cheapest flights from North Carolina to SantiagoExplore the most affordable flight options available from North Carolina to Santiago. Find the lowest fares from popular airlines and budget airlines, with prices last updated on February 3, 2026.
Explore the most affordable flight options available from North Carolina to Santiago. Find the lowest fares from popular airlines and budget airlines, with prices last updated on February 3, 2026.
This Mytrip deal was found by Cheapflights users on 2/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 3/186:00 am
CLT
- SCL
2 stops27h 39m
Multiple Airlines
Wed 3/259:05 pm
SCL
- CLT
2 stops16h 02m
Multiple Airlines
Deal found 2/1![Multiple Airlines logo]()
$557
This Mytrip deal was found by Cheapflights users on 2/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 4/228:55 am
CLT
- SCL
2 stops19h 21m
Multiple Airlines
Mon 5/411:35 am
SCL
- CLT
2 stops26h 38m
Multiple Airlines
Deal found 2/2![Multiple Airlines logo]()
$599
This Mytrip deal was found by Cheapflights users on 2/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 3/307:00 am
CLT
- SCL
2 stops30h 40m
Multiple Airlines
Tue 4/284:50 pm
SCL
- CLT
2 stops21h 23m
Multiple Airlines
Deal found 2/3![Multiple Airlines logo]()
$600
This Kiwi.com deal was found by Cheapflights users on 2/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 3/58:20 pm
RDU
- SCL
2 stops25h 20m
Multiple Airlines
Wed 3/1110:35 am
SCL
- RDU
1 stop22h 42m
Multiple Airlines
Deal found 2/2![Multiple Airlines logo]()
$610
This Mytrip deal was found by Cheapflights users on 2/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 4/17:00 am
CLT
- SCL
2 stops30h 30m
Multiple Airlines
Mon 4/63:42 pm
SCL
- CLT
3 stops28h 06m
Multiple Airlines
Deal found 2/3![Multiple Airlines logo]()
$618
This Mytrip deal was found by Cheapflights users on 2/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 4/298:55 am
CLT
- SCL
2 stops19h 21m
Multiple Airlines
Tue 5/124:50 pm
SCL
- CLT
2 stops21h 23m
Multiple Airlines
Deal found 2/3![Multiple Airlines logo]()
$631
This Mytrip deal was found by Cheapflights users on 2/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 3/149:49 pm
MYR
- SCL
3 stops39h 51m
Multiple Airlines
Fri 3/2011:24 am
SCL
- MYR
2 stops31h 09m
Multiple Airlines
Deal found 2/2![Multiple Airlines logo]()
$639
This Kiwi.com deal was found by Cheapflights users on 2/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 2/29:56 pm
RDU
- SCL
2 stops31h 44m
Multiple Airlines
Thu 3/1210:35 am
SCL
- RDU
1 stop21h 47m
Multiple Airlines
Deal found 2/1![Multiple Airlines logo]()
$650
This FlightHub deal was found by Cheapflights users on 2/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure FlightHub is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 8/202:00 pm
RDU
- SCL
1 stop16h 50m
LATAM Airlines
Mon 8/2410:55 pm
SCL
- RDU
1 stop15h 28m
LATAM Airlines
Deal found 2/1![LATAM Airlines logo]()
$677
This FlightHub deal was found by Cheapflights users on 2/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure FlightHub is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 5/209:50 am
RDU
- SCL
1 stop21h 00m
LATAM Airlines
Fri 5/2911:00 pm
SCL
- RDU
1 stop21h 45m
LATAM Airlines
Deal found 2/1![LATAM Airlines logo]()
$693
This FlightHub deal was found by Cheapflights users on 2/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure FlightHub is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 8/222:00 pm
RDU
- SCL
1 stop16h 50m
LATAM Airlines
Fri 9/411:00 pm
SCL
- RDU
1 stop22h 00m
LATAM Airlines
Deal found 2/2![LATAM Airlines logo]()
$698
This FlightHub deal was found by Cheapflights users on 2/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure FlightHub is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 8/208:20 am
RDU
- SCL
1 stop22h 35m
LATAM Airlines
Thu 9/310:55 pm
SCL
- RDU
1 stop15h 28m
LATAM Airlines
Deal found 2/1![LATAM Airlines logo]()
$701
Best flights from North Carolina to SantiagoDiscover carefully curated flight deals from North Carolina to Santiago that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated February 3, 2026.
Discover carefully curated flight deals from North Carolina to Santiago that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated February 3, 2026.
This Mytrip deal was found by Cheapflights users on 2/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 3/181:20 pm
CLT
- SCL
2 stops20h 19m
Multiple Airlines
Wed 3/255:50 am
SCL
- CLT
2 stops31h 17m
Multiple Airlines
Deal found 2/2![Multiple Airlines logo]()
$561
This FlightHub deal was found by Cheapflights users on 2/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure FlightHub is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 5/209:50 am
RDU
- SCL
1 stop21h 00m
LATAM Airlines
Fri 5/2911:00 pm
SCL
- RDU
1 stop21h 45m
LATAM Airlines
Deal found 2/1![LATAM Airlines logo]()
$693
This American Airlines deal was found by Cheapflights users on 2/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 3/31:44 pm
GSO
- SCL
2 stops17h 46m
American Airlines
Tue 3/319:25 pm
SCL
- GSO
2 stops16h 16m
American Airlines
Deal found 2/1![American Airlines logo]()
$825
This United Airlines deal was found by Cheapflights users on 2/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 3/1811:30 am
GSO
- SCL
2 stops19h 20m
United Airlines
Wed 3/259:45 pm
SCL
- GSO
2 stops20h 56m
United Airlines
Deal found 2/1![United Airlines logo]()
$858
This Delta deal was found by Cheapflights users on 2/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 3/156:00 am
ILM
- SCL
2 stops22h 50m
Delta
Tue 3/318:55 pm
SCL
- ILM
2 stops21h 13m
Delta
Deal found 2/2![Delta logo]()
$860
This Mytrip deal was found by Cheapflights users on 2/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 4/228:55 am
CLT
- SCL
2 stops19h 21m
Multiple Airlines
Mon 5/411:35 am
SCL
- CLT
2 stops26h 38m
Multiple Airlines
Deal found 2/2![Multiple Airlines logo]()
$599
This Mytrip deal was found by Cheapflights users on 2/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 3/307:00 am
CLT
- SCL
3 stops28h 00m
Multiple Airlines
Tue 4/284:50 pm
SCL
- CLT
2 stops21h 23m
Multiple Airlines
Deal found 2/3![Multiple Airlines logo]()
$600
This FlightHub deal was found by Cheapflights users on 2/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure FlightHub is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 5/71:55 pm
RDU
- SCL
1 stop16h 55m
LATAM Airlines
Mon 5/1111:00 pm
SCL
- RDU
1 stop21h 45m
LATAM Airlines
Deal found 2/1![LATAM Airlines logo]()
$708
This Mytrip deal was found by Cheapflights users on 2/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 4/17:00 am
CLT
- SCL
2 stops30h 30m
Multiple Airlines
Mon 4/63:42 pm
SCL
- CLT
3 stops28h 06m
Multiple Airlines
Deal found 2/3![Multiple Airlines logo]()
$618
This FlightHub deal was found by Cheapflights users on 1/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure FlightHub is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 3/32:12 pm
RDU
- SCL
1 stop14h 43m
LATAM Airlines
Wed 3/1111:25 pm
SCL
- RDU
1 stop21h 31m
LATAM Airlines
Deal found 1/31![LATAM Airlines logo]()
$713
This American Airlines deal was found by Cheapflights users on 2/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 3/167:57 pm
ILM
- SCL
1 stop12h 08m
American Airlines
Tue 3/319:25 pm
SCL
- ILM
1 stop22h 52m
American Airlines
Deal found 2/1![American Airlines logo]()
$829
This Mytrip deal was found by Cheapflights users on 2/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 4/298:55 am
CLT
- SCL
2 stops19h 21m
Multiple Airlines
Tue 5/124:50 pm
SCL
- CLT
2 stops21h 23m
Multiple Airlines
Deal found 2/3![Multiple Airlines logo]()
$631
This FlightHub deal was found by Cheapflights users on 1/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure FlightHub is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 3/32:12 pm
RDU
- SCL
1 stop14h 43m
LATAM Airlines
Thu 3/1210:30 pm
SCL
- RDU
1 stop17h 23m
LATAM Airlines
Deal found 1/31![LATAM Airlines logo]()
$713
This Delta deal was found by Cheapflights users on 2/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 3/292:08 pm
AVL
- SCL
1 stop17h 07m
Delta
Tue 4/78:40 pm
SCL
- AVL
1 stop16h 38m
Delta
Deal found 2/3![Delta logo]()
$870
This American Airlines deal was found by Cheapflights users on 2/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 4/257:52 pm
ORF
- SCL
1 stop11h 13m
American Airlines
Tue 5/58:35 pm
SCL
- ORF
1 stop22h 47m
American Airlines
Deal found 2/1![American Airlines logo]()
$860
This Mytrip deal was found by Cheapflights users on 2/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 3/149:49 pm
MYR
- SCL
3 stops31h 51m
Multiple Airlines
Fri 3/2011:24 am
SCL
- MYR
2 stops31h 09m
Multiple Airlines
Deal found 2/2![Multiple Airlines logo]()
$647
This FlightHub deal was found by Cheapflights users on 2/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure FlightHub is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 3/32:12 pm
RDU
- SCL
1 stop14h 43m
LATAM Airlines
Sat 3/710:30 am
SCL
- RDU
2 stops15h 39m
LATAM Airlines
Deal found 2/2![LATAM Airlines logo]()
$717
This American Airlines deal was found by Cheapflights users on 2/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 3/2911:14 am
AVL
- SCL
2 stops19h 36m
American Airlines
Tue 4/78:35 pm
SCL
- AVL
2 stops15h 39m
American Airlines
Deal found 2/2![American Airlines logo]()
$865
This FlightHub deal was found by Cheapflights users on 2/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure FlightHub is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 3/32:12 pm
RDU
- SCL
1 stop14h 43m
LATAM Airlines
Fri 3/610:30 am
SCL
- RDU
2 stops15h 39m
LATAM Airlines
Deal found 2/2![LATAM Airlines logo]()
$717
This Delta deal was found by Cheapflights users on 2/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 7/56:05 pm
ORF
- SCL
2 stops20h 00m
Delta
Wed 7/158:40 pm
SCL
- ORF
1 stop20h 22m
Delta
Deal found 2/1![Delta logo]()
$965
This Mytrip deal was found by Cheapflights users on 2/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 3/115:55 am
CLT
- SCL
2 stops31h 45m
Multiple Airlines
Sun 3/155:50 am
SCL
- CLT
2 stops31h 17m
Multiple Airlines
Deal found 2/2![Multiple Airlines logo]()
$672
This United Airlines deal was found by Cheapflights users on 2/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 2/135:19 pm
GSO
- SCL
2 stops37h 31m
United Airlines
Sat 2/2110:45 pm
SCL
- GSO
2 stops47h 57m
United Airlines
Deal found 2/1![United Airlines logo]()
$1,115
This FlightHub deal was found by Cheapflights users on 2/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure FlightHub is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 3/78:08 am
RDU
- SCL
1 stop19h 27m
LATAM Airlines
Fri 3/1310:40 pm
SCL
- RDU
1 stop17h 13m
LATAM Airlines
Deal found 2/3![LATAM Airlines logo]()
$733
This Delta deal was found by Cheapflights users on 2/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 3/310:13 am
GSO
- SCL
1 stop19h 27m
Delta
Tue 3/318:40 pm
SCL
- GSO
1 stop15h 55m
Delta
Deal found 2/1![Delta logo]()
$998
This Mytrip deal was found by Cheapflights users on 2/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 3/209:49 pm
MYR
- SCL
3 stops39h 51m
Multiple Airlines
Fri 3/2711:24 am
SCL
- MYR
2 stops31h 09m
Multiple Airlines
Deal found 2/3![Multiple Airlines logo]()
$716
This Ovago deal was found by Cheapflights users on 2/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Ovago is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 3/188:45 am
TYS
- SCL
1 stop21h 55m
LATAM Airlines
Thu 3/2610:25 pm
SCL
- TYS
1 stop20h 20m
LATAM Airlines
Deal found 2/3![LATAM Airlines logo]()
$784
This Mytrip deal was found by Cheapflights users on 1/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 3/36:08 pm
RDU
- SCL
2 stops28h 22m
Multiple Airlines
Wed 3/1111:24 am
SCL
- RDU
2 stops32h 20m
Multiple Airlines
Deal found 1/31![Multiple Airlines logo]()
$729
This Ovago deal was found by Cheapflights users on 2/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Ovago is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 3/1610:10 am
ILM
- SCL
1 stop20h 30m
LATAM Airlines
Tue 3/318:40 pm
SCL
- ILM
1 stop28h 19m
LATAM Airlines
Deal found 2/3![LATAM Airlines logo]()
$794
This Mytrip deal was found by Cheapflights users on 2/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 4/258:24 pm
ORF
- SCL
2 stops31h 53m
Multiple Airlines
Mon 5/412:30 am
SCL
- ORF
2 stops22h 29m
Multiple Airlines
Deal found 2/3![Multiple Airlines logo]()
$736
This Kiwi.com deal was found by Cheapflights users on 2/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 4/412:45 pm
RDU
- SCL
2 stops16h 45m
Multiple Airlines
Sat 4/118:30 am
SCL
- RDU
2 stops22h 49m
Multiple Airlines
Deal found 2/2![Multiple Airlines logo]()
$738
Last-minute flights from North Carolina to SantiagoDiscover last-minute flight deals from North Carolina to Santiago. Data last updated February 3, 2026 and is based on user searches.
Discover last-minute flight deals from North Carolina to Santiago. Data last updated February 3, 2026 and is based on user searches.
This Kiwi.com deal was found by Cheapflights users on 2/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 2/69:36 pm
RDU
- SCL
2 stops32h 04m
Multiple Airlines
Wed 3/1110:35 am
SCL
- RDU
1 stop22h 42m
Multiple Airlines
Deal found 2/1![Multiple Airlines logo]()
$706
This Kiwi.com deal was found by Cheapflights users on 2/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 2/69:36 pm
RDU
- SCL
2 stops32h 04m
Multiple Airlines
Thu 3/1910:35 am
SCL
- RDU
1 stop30h 22m
Multiple Airlines
Deal found 2/1![Multiple Airlines logo]()
$712
This FlightHub deal was found by Cheapflights users on 2/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure FlightHub is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 3/22:12 pm
RDU
- SCL
1 stop14h 43m
LATAM Airlines
Mon 3/910:30 pm
SCL
- RDU
1 stop17h 23m
LATAM Airlines
Deal found 2/2![LATAM Airlines logo]()
$724
This FlightHub deal was found by Cheapflights users on 2/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure FlightHub is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 3/32:12 pm
RDU
- SCL
1 stop14h 43m
LATAM Airlines
Sat 3/710:30 pm
SCL
- RDU
1 stop17h 23m
LATAM Airlines
Deal found 2/2![LATAM Airlines logo]()
$710
This FlightHub deal was found by Cheapflights users on 1/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure FlightHub is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 3/32:12 pm
RDU
- SCL
1 stop14h 43m
LATAM Airlines
Thu 3/1210:30 pm
SCL
- RDU
1 stop17h 23m
LATAM Airlines
Deal found 1/31![LATAM Airlines logo]()
$713
This FlightHub deal was found by Cheapflights users on 2/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure FlightHub is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 3/32:12 pm
RDU
- SCL
1 stop14h 43m
LATAM Airlines
Fri 3/610:30 am
SCL
- RDU
2 stops15h 39m
LATAM Airlines
Deal found 2/2![LATAM Airlines logo]()
$717
This Kiwi.com deal was found by Cheapflights users on 2/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 3/58:20 pm
RDU
- SCL
2 stops25h 20m
Multiple Airlines
Wed 3/1110:35 am
SCL
- RDU
1 stop22h 42m
Multiple Airlines
Deal found 2/2![Multiple Airlines logo]()
$610
This Mytrip deal was found by Cheapflights users on 2/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 3/115:55 am
CLT
- SCL
2 stops31h 45m
Multiple Airlines
Sun 3/155:50 am
SCL
- CLT
2 stops31h 17m
Multiple Airlines
Deal found 2/2![Multiple Airlines logo]()
$672
This Mytrip deal was found by Cheapflights users on 2/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 3/149:49 pm
MYR
- SCL
3 stops39h 51m
Multiple Airlines
Fri 3/2011:24 am
SCL
- MYR
2 stops31h 09m
Multiple Airlines
Deal found 2/2![Multiple Airlines logo]()
$639
This Mytrip deal was found by Cheapflights users on 2/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 3/186:00 am
CLT
- SCL
2 stops27h 39m
Multiple Airlines
Wed 3/259:05 pm
SCL
- CLT
2 stops16h 02m
Multiple Airlines
Deal found 2/1![Multiple Airlines logo]()
$557
This Mytrip deal was found by Cheapflights users on 2/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 3/209:49 pm
MYR
- SCL
3 stops39h 51m
Multiple Airlines
Fri 3/2711:24 am
SCL
- MYR
2 stops31h 09m
Multiple Airlines
Deal found 2/3![Multiple Airlines logo]()
$716
This Mytrip deal was found by Cheapflights users on 2/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 3/307:00 am
CLT
- SCL
2 stops30h 40m
Multiple Airlines
Tue 4/284:50 pm
SCL
- CLT
2 stops21h 23m
Multiple Airlines
Deal found 2/3![Multiple Airlines logo]()
$600
One-way flights from North Carolina to SantiagoSearch for one-way flight options from North Carolina to Santiago. Find affordable one-way fares based on user searches. Data last updated February 3, 2026.
Search for one-way flight options from North Carolina to Santiago. Find affordable one-way fares based on user searches. Data last updated February 3, 2026.
This Mytrip deal was found by Cheapflights users on 2/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 3/256:00 am
CLT
- SCL
2 stops27h 39m
Multiple Airlines
Deal found 2/2![Multiple Airlines logo]()
$254
This Kiwi.com deal was found by Cheapflights users on 2/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 3/1510:17 pm
RDU
- SCL
2 stops39h 23m
Multiple Airlines
Deal found 2/1![Multiple Airlines logo]()
$265
This Kiwi.com deal was found by Cheapflights users on 2/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 3/254:12 pm
RDU
- SCL
3 stops29h 03m
Multiple Airlines
Deal found 2/2![Multiple Airlines logo]()
$301
This Kiwi.com deal was found by Cheapflights users on 2/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 4/49:25 pm
RDU
- SCL
3 stops56h 05m
Multiple Airlines
Deal found 2/2![Multiple Airlines logo]()
$319
This Air Canada deal was found by Cheapflights users on 2/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Air Canada is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 3/159:30 am
RDU
- SCL
1 stop24h 45m
Air Canada
Deal found 2/1![Air Canada logo]()
$362
This KAYAK deal was found by Cheapflights users on 2/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure KAYAK is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 3/253:25 pm
CLT
- SCL
1 stop13h 30m
LATAM Airlines
Deal found 2/2![LATAM Airlines logo]()
$380
This eDestinos deal was found by Cheapflights users on 2/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure eDestinos is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 2/153:37 pm
CLT
- SCL
2 stops38h 03m
Multiple Airlines
Deal found 2/3![Multiple Airlines logo]()
$389
This Kiwi.com deal was found by Cheapflights users on 1/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 3/13:08 pm
RDU
- SCL
2 stops41h 31m
Multiple Airlines
Deal found 1/31![Multiple Airlines logo]()
$419
This American Airlines deal was found by Cheapflights users on 1/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 3/18:47 am
RDU
- SCL
1 stop21h 18m
American Airlines
Deal found 1/31![American Airlines logo]()
$438
This United Airlines deal was found by Cheapflights users on 1/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 2/284:47 pm
RDU
- SCL
1 stop14h 03m
United Airlines
Deal found 1/31![United Airlines logo]()
$463
This United Airlines deal was found by Cheapflights users on 2/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 2/155:30 pm
CLT
- SCL
2 stops37h 20m
United Airlines
Deal found 2/1![United Airlines logo]()
$464
This Kiwi.com deal was found by Cheapflights users on 1/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 2/282:41 pm
RDU
- SCL
2 stops45h 59m
Multiple Airlines
Deal found 1/31![Multiple Airlines logo]()
$464
Find flight deals from North Carolina to Santiago
Keep the following information in mind while searching for North Carolina to Santiago flight deals. Data was last updated February 3, 2026.
Most accurate provider | FlightHub 3 stars |
|---|---|
Most trusted provider | FlightHub 3 stars |
Round-trip from | $557 (Mytrip) |
One-way from | $254 (Mytrip) |
Popular in | March |
Cheapest in | October |
Average price | $913 |
Cheapflights Fare Finder
Customize your flight search to find flights from North Carolina to Santiago that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated February 3, 2026.
Use the filters below to find and compare flights from North Carolina to Santiago that are best for you.
Fly from
North Carolina
Fly to
Santiago
Route
Depart
Return
Price
CharlotteSantiago
CLT - SCL
CLTSCL
Charlotte Douglas
Wed 3/18
1:20 pm-10:39 am
2 stops20h 19m
Santiago Arturo Merino Benitez
Wed 3/25
5:50 am-12:07 pm
2 stops31h 17m
$561
CharlotteSantiago
CLT - SCL
CLTSCL
Charlotte Douglas
Wed 4/22
8:55 am-4:16 am
2 stops19h 21m
Santiago Arturo Merino Benitez
Mon 5/4
11:35 am-2:13 pm
2 stops26h 38m
$599
CharlotteSantiago
CLT - SCL
CLTSCL
Charlotte Douglas
Mon 3/30
7:00 am-12:00 pm
3 stops28h 00m
Santiago Arturo Merino Benitez
Tue 4/28
4:50 pm-2:13 pm
2 stops21h 23m
$600
CharlotteSantiago
CLT - SCL
CLTSCL
Charlotte Douglas
Wed 4/1
7:00 am-2:30 pm
2 stops30h 30m
Santiago Arturo Merino Benitez
Mon 4/6
3:42 pm-7:48 pm
3 stops28h 06m
$618
CharlotteSantiago
CLT - SCL
CLTSCL
Charlotte Douglas
Wed 4/29
8:55 am-4:16 am
2 stops19h 21m
Santiago Arturo Merino Benitez
Tue 5/12
4:50 pm-2:13 pm
2 stops21h 23m
$631
Myrtle BeachSantiago
MYR - SCL
MYRSCL
Myrtle Beach Intl
Sat 3/14
9:49 pm-6:40 am
3 stops31h 51m
Santiago Arturo Merino Benitez
Fri 3/20
11:24 am-5:33 pm
2 stops31h 09m
$647
CharlotteSantiago
CLT - SCL
CLTSCL
Charlotte Douglas
Wed 3/11
5:55 am-2:40 pm
2 stops31h 45m
Santiago Arturo Merino Benitez
Sun 3/15
5:50 am-12:07 pm
2 stops31h 17m
$672
RaleighSantiago
RDU - SCL
RDUSCL
Raleigh-Durham
Wed 5/20
9:50 am-6:50 am
1 stop21h 00m
Santiago Arturo Merino Benitez
Fri 5/29
11:00 pm-8:45 pm
1 stop21h 45m
$693
RaleighSantiago
RDU - SCL
RDUSCL
Raleigh-Durham
Thu 5/7
1:55 pm-6:50 am
1 stop16h 55m
Santiago Arturo Merino Benitez
Mon 5/11
11:00 pm-8:45 pm
1 stop21h 45m
$708
RaleighSantiago
RDU - SCL
RDUSCL
Raleigh-Durham
Tue 3/3
2:12 pm-6:55 am
1 stop14h 43m
Santiago Arturo Merino Benitez
Wed 3/11
11:25 pm-7:56 pm
1 stop21h 31m
$713
Showing 1-10 of 51 results
Best time to book a flight from North Carolina to Santiago
Have a flexible travel schedule? Discover the best time to fly to Santiago from North Carolina with our price prediction graph.
CLT-SCL
RDU-SCL
AVL-SCL
TYS-SCL
ORF-SCL
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.
Cheapflights Insights
Everything you need to know about your flight from North Carolina to Santiago
USNC-SCL
CLT-SCL
RDU-SCL
AVL-SCL
TYS-SCL
What is the cheapest month to book a flight from North Carolina to Santiago?
Currently, July is the cheapest month in which you can book a flight from North Carolina to Santiago (average of $401). Flying from North Carolina to Santiago in June is currently the most expensive (average of $779). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.
Related info for your journey
Find useful and relevant information for your journey from North Carolina to Santiago. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.
Browse thousands of different options on Cheapflights for your next trip
Toggle through the tabs below to find thousands of options on Cheapflights for your next trip.
Alternative routes
Complete your trip
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Other flight options
Popular flights
Santiago flight routes
Top destinations
Alternative routes for North Carolina to Santiago
See prices for flight routes from nearby airports that may be better suited for you.
Complete your trip
Complete your trip to Santiago by adding a car rental and/or hotel reservation to your travel itinerary.
Search flights from North Carolina to Santiago by cabin class
Find flights from North Carolina to Santiago, based on your preferred cabin class, be it economy, premium economy, business, or first class.
North Carolina and Santiago flights
Browse other North Carolina and Santiago flight options. Last updated on February 3, 2026.
Popular flight searches
Check out other popular destinations found by fellow travelers in 2026
Other flights to Santiago
Explore flights to Santiago departing from other origins. Flights are based on user searches made on Cheapflights and were last updated on February 3, 2026.
North Carolina to Santiago flights
Consider these flights traveling from North Carolina to Santiago.
Top 3 airlines flying from North Carolina to Santiago
Discover the top 3 airlines that operate flights from North Carolina to Santiago. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated February 3, 2026.
| Airline | Cheapest | Average | Flexibility | On-time |
|---|---|---|---|---|
| Cheapest$402 | Average$930 | FlexibilityNo cancel fee | On-timeN/A | |
| Cheapest$505 | Average$919 | FlexibilityNo cancel fee | On-time71% | |
| Cheapest$523 | Average$918 | FlexibilityNo cancel fee | On-time81% |