$349+ Cheap flights from North Carolina to Santiago (SCL)
This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 4/16. Fares are subject to change and may not be available on all flights or dates of travel.
CLT — SCL
Apr 20 — Apr 271
Round-trip
1 adult, Economy
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Cheapest flights from North Carolina to SantiagoExplore the most affordable flight options available from North Carolina to Santiago. Find the lowest fares from popular airlines and budget airlines, with prices last updated on March 21, 2026.
Explore the most affordable flight options available from North Carolina to Santiago. Find the lowest fares from popular airlines and budget airlines, with prices last updated on March 21, 2026.
This flugladen.de deal was found by Cheapflights users on 3/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure flugladen.de is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 4/196:30 am
CLT
- SCL
2 stops22h 15m
Multiple Airlines
Sun 4/263:20 pm
SCL
- CLT
2 stops20h 25m
Multiple Airlines
Deal found 3/20![Multiple Airlines logo]()
$643
This Trip.com deal was found by Cheapflights users on 3/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Trip.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 4/199:03 am
RDU
- SCL
2 stops20h 27m
Multiple Airlines
Sun 4/265:00 am
SCL
- RDU
2 stops27h 18m
Multiple Airlines
Deal found 3/20![Multiple Airlines logo]()
$651
This FlightHub deal was found by Cheapflights users on 3/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure FlightHub is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 4/172:03 pm
RDU
- SCL
1 stop16h 22m
LATAM Airlines
Wed 4/2210:55 pm
SCL
- RDU
1 stop16h 41m
LATAM Airlines
Deal found 3/17![LATAM Airlines logo]()
$655
This Trip.com deal was found by Cheapflights users on 3/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Trip.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 4/176:30 am
CLT
- SCL
2 stops22h 15m
Multiple Airlines
Sun 4/196:40 am
SCL
- CLT
2 stops29h 05m
Multiple Airlines
Deal found 3/17![Multiple Airlines logo]()
$669
This American Airlines deal was found by Cheapflights users on 3/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 4/197:55 pm
RDU
- SCL
1 stop11h 10m
American Airlines
Sun 4/268:35 pm
SCL
- RDU
2 stops15h 44m
American Airlines
Deal found 3/20![American Airlines logo]()
$669
This Trip.com deal was found by Cheapflights users on 3/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Trip.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 4/166:30 am
CLT
- SCL
2 stops22h 15m
Multiple Airlines
Wed 4/226:40 am
SCL
- CLT
2 stops29h 05m
Multiple Airlines
Deal found 3/16![Multiple Airlines logo]()
$674
This LATAM Airlines deal was found by Cheapflights users on 3/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure LATAM Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 4/1312:47 pm
RDU
- SCL
2 stops17h 13m
LATAM Airlines
Sat 4/186:45 pm
SCL
- RDU
2 stops16h 57m
LATAM Airlines
Deal found 3/21![LATAM Airlines logo]()
$675
This Gurufare deal was found by Cheapflights users on 3/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Gurufare is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 5/54:56 pm
RDU
- SCL
1 stop14h 19m
LATAM Airlines
Tue 5/1210:55 pm
SCL
- RDU
1 stop15h 45m
LATAM Airlines
Deal found 3/21![LATAM Airlines logo]()
$677
This American Airlines deal was found by Cheapflights users on 3/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 5/311:27 am
RDU
- SCL
1 stop19h 38m
American Airlines
Sun 5/108:35 pm
SCL
- RDU
2 stops15h 44m
American Airlines
Deal found 3/19![American Airlines logo]()
$682
This Trip.com deal was found by Cheapflights users on 3/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Trip.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 4/166:30 am
CLT
- SCL
2 stops22h 15m
Multiple Airlines
Thu 4/236:40 am
SCL
- CLT
2 stops29h 05m
Multiple Airlines
Deal found 3/17![Multiple Airlines logo]()
$685
This Copa Airlines deal was found by Cheapflights users on 3/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Copa Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 4/194:18 pm
RDU
- SCL
1 stop12h 52m
Copa Airlines
Sat 4/252:30 am
SCL
- RDU
1 stop11h 59m
Copa Airlines
Deal found 3/20![Copa Airlines logo]()
$685
This American Airlines deal was found by Cheapflights users on 3/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 5/3112:56 pm
RDU
- SCL
2 stops18h 09m
American Airlines
Mon 6/89:00 pm
SCL
- RDU
1 stop24h 30m
American Airlines
Deal found 3/20![American Airlines logo]()
$695
Best flights from North Carolina to SantiagoDiscover carefully curated flight deals from North Carolina to Santiago that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated March 21, 2026.
Discover carefully curated flight deals from North Carolina to Santiago that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated March 21, 2026.
This Trip.com deal was found by Cheapflights users on 3/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Trip.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 4/166:30 am
CLT
- SCL
2 stops22h 15m
Multiple Airlines
Wed 4/226:40 am
SCL
- CLT
2 stops29h 05m
Multiple Airlines
Deal found 3/16![Multiple Airlines logo]()
$674
This LATAM Airlines deal was found by Cheapflights users on 3/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure LATAM Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 4/1312:47 pm
RDU
- SCL
2 stops17h 13m
LATAM Airlines
Sat 4/186:45 pm
SCL
- RDU
2 stops16h 57m
LATAM Airlines
Deal found 3/21![LATAM Airlines logo]()
$675
This Copa Airlines deal was found by Cheapflights users on 3/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Copa Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 4/194:18 pm
RDU
- SCL
1 stop12h 52m
Copa Airlines
Sat 4/252:30 am
SCL
- RDU
1 stop11h 59m
Copa Airlines
Deal found 3/20![Copa Airlines logo]()
$685
This Delta deal was found by Cheapflights users on 3/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 4/136:07 pm
RDU
- SCL
2 stops19h 38m
Delta
Sat 4/1811:00 pm
SCL
- RDU
1 stop21h 59m
Delta
Deal found 3/18![Delta logo]()
$727
This American Airlines deal was found by Cheapflights users on 3/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 8/279:08 am
ILM
- SCL
2 stops21h 42m
American Airlines
Thu 9/38:30 pm
SCL
- ILM
2 stops18h 09m
American Airlines
Deal found 3/20![American Airlines logo]()
$880
This United Airlines deal was found by Cheapflights users on 3/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 5/111:26 am
AVL
- SCL
2 stops31h 57m
United Airlines
Fri 5/811:17 am
SCL
- AVL
2 stops23h 26m
United Airlines
Deal found 3/17![United Airlines logo]()
$1,233
This Trip.com deal was found by Cheapflights users on 3/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Trip.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 4/176:30 am
CLT
- SCL
2 stops22h 15m
Multiple Airlines
Wed 4/223:20 pm
SCL
- CLT
2 stops20h 25m
Multiple Airlines
Deal found 3/16![Multiple Airlines logo]()
$674
This Copa Airlines deal was found by Cheapflights users on 3/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Copa Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 5/314:19 pm
RDU
- SCL
1 stop12h 51m
Copa Airlines
Sun 6/72:22 am
SCL
- RDU
1 stop12h 07m
Copa Airlines
Deal found 3/20![Copa Airlines logo]()
$685
This LATAM Airlines deal was found by Cheapflights users on 3/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure LATAM Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 4/146:09 pm
RDU
- SCL
1 stop13h 06m
LATAM Airlines
Thu 4/309:10 pm
SCL
- RDU
2 stops27h 08m
LATAM Airlines
Deal found 3/21![LATAM Airlines logo]()
$732
This Trip.com deal was found by Cheapflights users on 3/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Trip.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 4/166:30 am
CLT
- SCL
2 stops22h 15m
Multiple Airlines
Thu 4/236:40 am
SCL
- CLT
2 stops29h 05m
Multiple Airlines
Deal found 3/17![Multiple Airlines logo]()
$687
This Delta deal was found by Cheapflights users on 3/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 4/28:20 am
RDU
- SCL
1 stop21h 35m
Delta
Wed 4/87:45 am
SCL
- RDU
2 stops16h 33m
Delta
Deal found 3/18![Delta logo]()
$772
This LATAM Airlines deal was found by Cheapflights users on 3/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure LATAM Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 5/294:15 pm
RDU
- SCL
1 stop15h 00m
LATAM Airlines
Tue 6/25:40 am
SCL
- RDU
2 stops18h 36m
LATAM Airlines
Deal found 3/19![LATAM Airlines logo]()
$777
This Mytrip deal was found by Cheapflights users on 3/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 5/36:30 am
CLT
- SCL
2 stops22h 15m
Multiple Airlines
Sat 5/912:30 am
SCL
- CLT
2 stops35h 15m
Multiple Airlines
Deal found 3/19![Multiple Airlines logo]()
$756
This American Airlines deal was found by Cheapflights users on 3/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 5/411:13 am
GSO
- SCL
2 stops19h 52m
American Airlines
Mon 5/118:35 pm
SCL
- GSO
2 stops16h 00m
American Airlines
Deal found 3/20![American Airlines logo]()
$925
This Delta deal was found by Cheapflights users on 3/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 8/122:30 pm
ILM
- SCL
1 stop16h 45m
Delta
Wed 8/198:40 pm
SCL
- ILM
1 stop13h 02m
Delta
Deal found 3/21![Delta logo]()
$875
This Copa Airlines deal was found by Cheapflights users on 3/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Copa Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 8/76:00 am
CLT
- SCL
2 stops23h 03m
Copa Airlines
Fri 8/2111:22 am
SCL
- CLT
2 stops22h 20m
Copa Airlines
Deal found 3/16![Copa Airlines logo]()
$878
This American Airlines deal was found by Cheapflights users on 3/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 5/411:08 am
TRI
- SCL
2 stops19h 57m
American Airlines
Mon 5/118:35 pm
SCL
- TRI
2 stops20h 00m
American Airlines
Deal found 3/20![American Airlines logo]()
$925
This Mytrip deal was found by Cheapflights users on 3/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 4/169:37 pm
RDU
- SCL
2 stops26h 34m
Multiple Airlines
Wed 4/223:20 pm
SCL
- RDU
2 stops29h 12m
Multiple Airlines
Deal found 3/16![Multiple Airlines logo]()
$766
This LATAM Airlines deal was found by Cheapflights users on 3/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure LATAM Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 8/122:30 pm
ILM
- SCL
2 stops16h 25m
LATAM Airlines
Wed 8/198:40 pm
SCL
- ILM
1 stop16h 58m
LATAM Airlines
Deal found 3/21![LATAM Airlines logo]()
$861
This American Airlines deal was found by Cheapflights users on 3/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 4/1612:05 pm
MYR
- SCL
2 stops19h 00m
American Airlines
Wed 4/228:35 pm
SCL
- MYR
2 stops25h 21m
American Airlines
Deal found 3/16![American Airlines logo]()
$940
This Mytrip deal was found by Cheapflights users on 3/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 4/207:12 am
CLT
- SCL
3 stops22h 18m
Multiple Airlines
Sat 5/163:20 pm
SCL
- CLT
3 stops32h 39m
Multiple Airlines
Deal found 3/16![Multiple Airlines logo]()
$784
This FlightHub deal was found by Cheapflights users on 3/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure FlightHub is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 4/163:21 pm
CLT
- SCL
1 stop15h 04m
LATAM Airlines
Wed 4/2210:55 pm
SCL
- CLT
1 stop15h 45m
LATAM Airlines
Deal found 3/16![LATAM Airlines logo]()
$879
This Delta deal was found by Cheapflights users on 3/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 5/41:54 pm
TRI
- SCL
1 stop17h 21m
Delta
Mon 5/118:40 pm
SCL
- TRI
1 stop12h 51m
Delta
Deal found 3/20![Delta logo]()
$970
This Delta deal was found by Cheapflights users on 3/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 6/176:05 pm
ORF
- SCL
2 stops20h 00m
Delta
Thu 6/2510:55 pm
SCL
- ORF
1 stop17h 58m
Delta
Deal found 3/17![Delta logo]()
$975
This American Airlines deal was found by Cheapflights users on 3/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 6/1711:05 am
ORF
- SCL
2 stops20h 00m
American Airlines
Thu 6/259:00 pm
SCL
- ORF
1 stop21h 59m
American Airlines
Deal found 3/19![American Airlines logo]()
$980
This FlightHub deal was found by Cheapflights users on 3/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure FlightHub is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 5/282:14 pm
CLT
- SCL
1 stop16h 36m
LATAM Airlines
Thu 6/2510:55 pm
SCL
- CLT
1 stop14h 57m
LATAM Airlines
Deal found 3/17![LATAM Airlines logo]()
$906
This Mytrip deal was found by Cheapflights users on 3/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 4/178:31 pm
MYR
- SCL
3 stops32h 59m
Multiple Airlines
Wed 4/223:30 pm
SCL
- MYR
3 stops31h 59m
Multiple Airlines
Deal found 3/16![Multiple Airlines logo]()
$833
This American Airlines deal was found by Cheapflights users on 3/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 7/56:58 pm
ORF
- SCL
1 stop11h 52m
American Airlines
Wed 7/158:30 pm
SCL
- ORF
2 stops20h 24m
American Airlines
Deal found 3/17![American Airlines logo]()
$980
This FlightHub deal was found by Cheapflights users on 3/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure FlightHub is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 4/173:21 pm
CLT
- SCL
1 stop15h 04m
LATAM Airlines
Wed 4/2211:00 pm
SCL
- CLT
2 stops19h 11m
LATAM Airlines
Deal found 3/16![LATAM Airlines logo]()
$908
This KAYAK deal was found by Cheapflights users on 3/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure KAYAK is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 5/312:25 pm
ORF
- SCL
2 stops35h 04m
LATAM Airlines
Sun 5/1011:05 pm
SCL
- ORF
2 stops25h 43m
LATAM Airlines
Deal found 3/17![LATAM Airlines logo]()
$920
Last-minute flights from North Carolina to SantiagoDiscover last-minute flight deals from North Carolina to Santiago. Data last updated March 21, 2026 and is based on user searches.
Discover last-minute flight deals from North Carolina to Santiago. Data last updated March 21, 2026 and is based on user searches.
This FlightHub deal was found by Cheapflights users on 3/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure FlightHub is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 4/18:05 am
RDU
- SCL
1 stop21h 30m
LATAM Airlines
Tue 4/77:15 am
SCL
- RDU
2 stops17h 03m
LATAM Airlines
Deal found 3/18![LATAM Airlines logo]()
$721
This LATAM Airlines deal was found by Cheapflights users on 3/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure LATAM Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 4/1312:47 pm
RDU
- SCL
2 stops17h 13m
LATAM Airlines
Sat 4/186:45 pm
SCL
- RDU
2 stops16h 57m
LATAM Airlines
Deal found 3/21![LATAM Airlines logo]()
$675
This eDestinos deal was found by Cheapflights users on 3/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure eDestinos is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 4/134:46 pm
RDU
- SCL
2 stops44h 49m
Multiple Airlines
Sat 4/188:20 pm
SCL
- RDU
2 stops35h 58m
Multiple Airlines
Deal found 3/20![Multiple Airlines logo]()
$724
This Delta deal was found by Cheapflights users on 3/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 4/134:58 pm
RDU
- SCL
1 stop14h 17m
Delta
Sat 4/1811:00 pm
SCL
- RDU
1 stop21h 59m
Delta
Deal found 3/18![Delta logo]()
$727
This Trip.com deal was found by Cheapflights users on 3/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Trip.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 4/166:30 am
CLT
- SCL
2 stops22h 15m
Multiple Airlines
Wed 4/226:40 am
SCL
- CLT
2 stops29h 05m
Multiple Airlines
Deal found 3/16![Multiple Airlines logo]()
$674
This Trip.com deal was found by Cheapflights users on 3/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Trip.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 4/166:30 am
CLT
- SCL
2 stops22h 15m
Multiple Airlines
Thu 4/236:40 am
SCL
- CLT
2 stops29h 05m
Multiple Airlines
Deal found 3/17![Multiple Airlines logo]()
$685
This FlightHub deal was found by Cheapflights users on 3/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure FlightHub is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 4/172:03 pm
RDU
- SCL
1 stop16h 22m
LATAM Airlines
Wed 4/2210:55 pm
SCL
- RDU
1 stop16h 41m
LATAM Airlines
Deal found 3/17![LATAM Airlines logo]()
$655
This Trip.com deal was found by Cheapflights users on 3/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Trip.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 4/176:30 am
CLT
- SCL
2 stops22h 15m
Multiple Airlines
Sun 4/196:40 am
SCL
- CLT
2 stops29h 05m
Multiple Airlines
Deal found 3/17![Multiple Airlines logo]()
$669
This flugladen.de deal was found by Cheapflights users on 3/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure flugladen.de is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 4/196:30 am
CLT
- SCL
2 stops22h 15m
Multiple Airlines
Sun 4/263:20 pm
SCL
- CLT
2 stops20h 25m
Multiple Airlines
Deal found 3/20![Multiple Airlines logo]()
$643
This Trip.com deal was found by Cheapflights users on 3/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Trip.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 4/199:03 am
RDU
- SCL
2 stops20h 27m
Multiple Airlines
Sun 4/265:00 am
SCL
- RDU
2 stops27h 18m
Multiple Airlines
Deal found 3/20![Multiple Airlines logo]()
$651
This American Airlines deal was found by Cheapflights users on 3/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 4/197:55 pm
RDU
- SCL
1 stop11h 10m
American Airlines
Sun 4/268:35 pm
SCL
- RDU
2 stops15h 44m
American Airlines
Deal found 3/20![American Airlines logo]()
$669
This Copa Airlines deal was found by Cheapflights users on 3/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Copa Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 4/194:18 pm
RDU
- SCL
1 stop12h 52m
Copa Airlines
Sat 4/252:30 am
SCL
- RDU
1 stop11h 59m
Copa Airlines
Deal found 3/20![Copa Airlines logo]()
$685
One-way flights from North Carolina to SantiagoSearch for one-way flight options from North Carolina to Santiago. Find affordable one-way fares based on user searches. Data last updated March 21, 2026.
Search for one-way flight options from North Carolina to Santiago. Find affordable one-way fares based on user searches. Data last updated March 21, 2026.
This Mytrip deal was found by Cheapflights users on 3/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 4/169:37 pm
RDU
- SCL
2 stops26h 34m
Multiple Airlines
Deal found 3/17![Multiple Airlines logo]()
$349
This Kiwi.com deal was found by Cheapflights users on 3/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 4/12:11 pm
RDU
- SCL
2 stops34h 00m
Multiple Airlines
Deal found 3/20![Multiple Airlines logo]()
$403
This Kiwi.com deal was found by Cheapflights users on 3/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 7/45:20 am
CLT
- SCL
3 stops46h 51m
Multiple Airlines
Deal found 3/21![Multiple Airlines logo]()
$424
This Kiwi.com deal was found by Cheapflights users on 3/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 6/21:00 pm
CLT
- SCL
2 stops17h 00m
Multiple Airlines
Deal found 3/18![Multiple Airlines logo]()
$435
This Kiwi.com deal was found by Cheapflights users on 3/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 5/214:30 pm
ILM
- SCL
3 stops37h 05m
Multiple Airlines
Deal found 3/19![Multiple Airlines logo]()
$439
This American Airlines deal was found by Cheapflights users on 3/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 5/216:57 pm
ILM
- SCL
1 stop12h 08m
American Airlines
Deal found 3/19![American Airlines logo]()
$448
This American Airlines deal was found by Cheapflights users on 3/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 5/226:57 pm
ILM
- SCL
1 stop12h 08m
American Airlines
Deal found 3/19![American Airlines logo]()
$498
This Delta deal was found by Cheapflights users on 3/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 4/19:54 am
RDU
- SCL
1 stop20h 31m
Delta
Deal found 3/20![Delta logo]()
$516
This American Airlines deal was found by Cheapflights users on 3/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 6/27:53 pm
CLT
- SCL
1 stop11h 12m
American Airlines
Deal found 3/18![American Airlines logo]()
$574
This United Airlines deal was found by Cheapflights users on 3/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 4/1512:09 pm
GSO
- SCL
2 stops38h 51m
United Airlines
Deal found 3/21![United Airlines logo]()
$598
This American Airlines deal was found by Cheapflights users on 3/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 7/317:43 pm
ILM
- SCL
1 stop11h 07m
American Airlines
Deal found 3/17![American Airlines logo]()
$628
This Gurufare deal was found by Cheapflights users on 3/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Gurufare is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 7/44:30 pm
CLT
- SCL
1 stop14h 45m
LATAM Airlines
Deal found 3/21![LATAM Airlines logo]()
$628
Find flight deals from North Carolina to Santiago
Keep the following information in mind while searching for North Carolina to Santiago flight deals. Data was last updated March 21, 2026.
Most accurate provider | FlightHub 3 stars |
|---|---|
Most trusted provider | FlightHub 3 stars |
Round-trip from | $643 (flugladen.de) |
One-way from | $349 (Mytrip) |
Popular in | May |
Cheapest in | October |
Average price | $817 |
Cheapflights Fare Finder
Customize your flight search to find flights from North Carolina to Santiago that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated March 21, 2026.
Use the filters below to find and compare flights from North Carolina to Santiago that are best for you.
Fly from
Fly to
Route
Depart
Return
Cheapest round-trip
CharlotteSantiago
CLT - SCL
CLTSCL
Charlotte Douglas
Thu 4/16
6:30 am-4:45 am
2 stops22h 15m
Santiago Arturo Merino Benitez
Wed 4/22
6:40 am-11:45 am
2 stops29h 05m
$674
CharlotteSantiago
CLT - SCL
CLTSCL
Charlotte Douglas
Fri 4/17
6:30 am-4:45 am
2 stops22h 15m
Santiago Arturo Merino Benitez
Wed 4/22
3:20 pm-11:45 am
2 stops20h 25m
$674
RaleighSantiago
RDU - SCL
RDUSCL
Raleigh-Durham
Mon 4/13
12:47 pm-6:00 am
2 stops17h 13m
Santiago Arturo Merino Benitez
Sat 4/18
6:45 pm-11:42 am
2 stops16h 57m
$675
Quickest round-trip
RaleighSantiago
RDU - SCL
RDUSCL
Raleigh-Durham
Sun 4/19
4:18 pm-5:10 am
1 stop12h 52m
Santiago Arturo Merino Benitez
Sat 4/25
2:30 am-2:29 pm
1 stop11h 59m
$685
RaleighSantiago
RDU - SCL
RDUSCL
Raleigh-Durham
Sun 5/31
4:19 pm-5:10 am
1 stop12h 51m
Santiago Arturo Merino Benitez
Sun 6/7
2:22 am-2:29 pm
1 stop12h 07m
$685
CharlotteSantiago
CLT - SCL
CLTSCL
Charlotte Douglas
Thu 4/16
6:30 am-4:45 am
2 stops22h 15m
Santiago Arturo Merino Benitez
Thu 4/23
6:40 am-11:45 am
2 stops29h 05m
$687
RaleighSantiago
RDU - SCL
RDUSCL
Raleigh-Durham
Mon 4/13
6:07 pm-1:45 pm
2 stops19h 38m
Santiago Arturo Merino Benitez
Sat 4/18
11:00 pm-8:59 pm
1 stop21h 59m
$727
RaleighSantiago
RDU - SCL
RDUSCL
Raleigh-Durham
Tue 4/14
6:09 pm-7:15 am
1 stop13h 06m
Santiago Arturo Merino Benitez
Thu 4/30
9:10 pm-12:18 am
2 stops27h 08m
$732
CharlotteSantiago
CLT - SCL
CLTSCL
Charlotte Douglas
Sun 5/3
6:30 am-4:45 am
2 stops22h 15m
Santiago Arturo Merino Benitez
Sat 5/9
12:30 am-11:45 am
2 stops35h 15m
$756
RaleighSantiago
RDU - SCL
RDUSCL
Raleigh-Durham
Thu 4/16
9:37 pm-12:11 am
2 stops26h 34m
Santiago Arturo Merino Benitez
Wed 4/22
3:20 pm-8:32 pm
2 stops29h 12m
$766
Showing 1-10 of 44 resultsSorted by cheapest first
Best time to book a flight from North Carolina to Santiago
Have a flexible travel schedule? Discover the best time to fly to Santiago from North Carolina with our price prediction graph.
CLT-SCL
RDU-SCL
ILM-SCL
GSO-SCL
AVL-SCL
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.
Cheapflights Insights
Everything you need to know about your flight from North Carolina to Santiago
USNC-SCL
CLT-SCL
RDU-SCL
ILM-SCL
GSO-SCL
What is the cheapest month to book a flight from North Carolina to Santiago?
Currently, July is the cheapest month in which you can book a flight from North Carolina to Santiago (average of $401). Flying from North Carolina to Santiago in June is currently the most expensive (average of $776). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.
Related info for your journey
Find useful and relevant information for your journey from North Carolina to Santiago. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.
Browse thousands of different options on Cheapflights for your next trip
Toggle through the tabs below to find thousands of options on Cheapflights for your next trip.
Alternative routes
Complete your trip
Flights by cabin class
Other flight options
Popular flights
Santiago flight routes
Top destinations
Alternative routes for North Carolina to Santiago
See prices for flight routes from nearby airports that may be better suited for you.
Complete your trip
Complete your trip to Santiago by adding a car rental and/or hotel reservation to your travel itinerary.
Search flights from North Carolina to Santiago by cabin class
Find flights from North Carolina to Santiago, based on your preferred cabin class, be it economy, premium economy, business, or first class.
North Carolina and Santiago flights
Browse other North Carolina and Santiago flight options. Last updated on March 21, 2026.
Popular flight searches
Check out other popular destinations found by fellow travelers in 2026
Other flights to Santiago
Explore flights to Santiago departing from other origins. Flights are based on user searches made on Cheapflights and were last updated on March 21, 2026.
North Carolina to Santiago flights
Consider these flights traveling from North Carolina to Santiago.
Top 3 airlines flying from North Carolina to Santiago
Discover the top 3 airlines that operate flights from North Carolina to Santiago. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated March 21, 2026.
| Airline | Cheapest | Average | Flexibility | On-time |
|---|---|---|---|---|
| Cheapest$402 | Average$958 | FlexibilityNo cancel fee | On-timeN/A | |
| Cheapest$505 | Average$907 | FlexibilityNo cancel fee | On-time71% | |
| Cheapest$523 | Average$920 | FlexibilityNo cancel fee | On-time81% |