$315+ Cheap flights from North Carolina to Santiago (SCL)
This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 6/1. Fares are subject to change and may not be available on all flights or dates of travel.
CLT — SCL
Jun 4 — Jun 111
Round-trip
1 adult, Economy
We work with more than 300 partners to bring you better travel deals
Find cheap flights from North Carolina to Santiago with Cheapflights
1. Tell us where you want to go
Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”2. Select your favorite providers
We find the providers serving your travel needs. Choose up to four travel providers to compare side-by-side for flights, hotels, or car rentals.3. Compare prices and book
Review each provider’s pricing and select the best option for you! Book through your favorite provider’s website for a seamless experience.Cheap flight deals from North Carolina to Santiago
Cheapest
Best
Last-minute
One-way
Cheapest flights from North Carolina to SantiagoExplore the most affordable flight options available from North Carolina to Santiago. Find the lowest fares from popular airlines and budget airlines, with prices last updated on May 5, 2026.
Explore the most affordable flight options available from North Carolina to Santiago. Find the lowest fares from popular airlines and budget airlines, with prices last updated on May 5, 2026.
This eDestinos deal was found by Cheapflights users on 5/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure eDestinos is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 5/318:09 am
RDU
- SCL
2 stops53h 21m
Multiple Airlines
Tue 6/23:35 am
SCL
- RDU
2 stops27h 49m
Multiple Airlines
Deal found 5/4![Multiple Airlines logo]()
$691
This eDestinos deal was found by Cheapflights users on 5/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure eDestinos is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 5/318:09 am
RDU
- SCL
2 stops53h 21m
Multiple Airlines
Mon 6/85:00 am
SCL
- RDU
2 stops37h 03m
Multiple Airlines
Deal found 5/4![Multiple Airlines logo]()
$696
This eDestinos deal was found by Cheapflights users on 5/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure eDestinos is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 5/302:32 pm
RDU
- SCL
3 stops39h 28m
Multiple Airlines
Sun 6/712:40 am
SCL
- RDU
2 stops41h 23m
Multiple Airlines
Deal found 5/4![Multiple Airlines logo]()
$730
This FlightHub deal was found by Cheapflights users on 4/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure FlightHub is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/710:00 am
RDU
- SCL
1 stop19h 25m
LATAM Airlines
Mon 11/211:05 pm
SCL
- RDU
1 stop23h 51m
LATAM Airlines
Deal found 4/30![LATAM Airlines logo]()
$783
This Mytrip deal was found by Cheapflights users on 5/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 5/2112:48 pm
CLT
- SCL
2 stops24h 42m
Multiple Airlines
Mon 5/253:20 pm
SCL
- CLT
2 stops32h 20m
Multiple Airlines
Deal found 5/1![Multiple Airlines logo]()
$796
This eDestinos deal was found by Cheapflights users on 5/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure eDestinos is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 5/318:04 am
RDU
- SCL
1 stop21h 31m
LATAM Airlines
Mon 6/811:00 pm
SCL
- RDU
1 stop21h 44m
LATAM Airlines
Deal found 5/4![LATAM Airlines logo]()
$800
This FlightHub deal was found by Cheapflights users on 5/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure FlightHub is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 9/1310:00 am
RDU
- SCL
1 stop19h 25m
LATAM Airlines
Wed 9/2311:00 pm
SCL
- RDU
1 stop23h 00m
LATAM Airlines
Deal found 5/4![LATAM Airlines logo]()
$801
This eDestinos deal was found by Cheapflights users on 4/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure eDestinos is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 6/67:58 pm
CLT
- SCL
2 stops41h 37m
Multiple Airlines
Fri 6/125:00 am
SCL
- CLT
2 stops36h 14m
Multiple Airlines
Deal found 4/30![Multiple Airlines logo]()
$805
This FlightHub deal was found by Cheapflights users on 5/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure FlightHub is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 10/51:15 pm
CLT
- SCL
1 stop16h 10m
LATAM Airlines
Thu 10/1510:55 pm
SCL
- CLT
1 stop15h 59m
LATAM Airlines
Deal found 5/1![LATAM Airlines logo]()
$810
This FlightHub deal was found by Cheapflights users on 4/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure FlightHub is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 6/131:53 pm
RDU
- SCL
1 stop16h 32m
LATAM Airlines
Sat 6/276:00 pm
SCL
- RDU
2 stops26h 44m
LATAM Airlines
Deal found 4/30![LATAM Airlines logo]()
$819
This FlightHub deal was found by Cheapflights users on 5/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure FlightHub is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/192:20 pm
CLT
- SCL
2 stops13h 15m
LATAM Airlines
Mon 11/3011:05 pm
SCL
- CLT
2 stops21h 07m
LATAM Airlines
Deal found 5/2![LATAM Airlines logo]()
$842
This Kiwi.com deal was found by Cheapflights users on 4/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 8/65:45 am
CLT
- SCL
1 stop25h 10m
Multiple Airlines
Mon 8/315:00 am
SCL
- CLT
2 stops36h 14m
Multiple Airlines
Deal found 4/30![Multiple Airlines logo]()
$844
Best flights from North Carolina to SantiagoDiscover carefully curated flight deals from North Carolina to Santiago that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated May 5, 2026.
Discover carefully curated flight deals from North Carolina to Santiago that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated May 5, 2026.
This eDestinos deal was found by Cheapflights users on 5/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure eDestinos is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 5/302:32 pm
RDU
- SCL
3 stops39h 28m
Multiple Airlines
Sun 6/712:40 am
SCL
- RDU
2 stops41h 23m
Multiple Airlines
Deal found 5/4![Multiple Airlines logo]()
$730
This FlightHub deal was found by Cheapflights users on 4/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure FlightHub is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/710:00 am
RDU
- SCL
1 stop19h 25m
LATAM Airlines
Mon 11/211:05 pm
SCL
- RDU
1 stop23h 51m
LATAM Airlines
Deal found 4/30![LATAM Airlines logo]()
$783
This Delta deal was found by Cheapflights users on 5/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 6/45:56 pm
RDU
- SCL
1 stop13h 19m
Delta
Sat 6/138:40 pm
SCL
- RDU
1 stop16h 04m
Delta
Deal found 5/3![Delta logo]()
$855
This Copa Airlines deal was found by Cheapflights users on 5/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Copa Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 8/17:44 pm
CLT
- SCL
2 stops33h 19m
Copa Airlines
Mon 11/303:50 am
SCL
- CLT
2 stops31h 54m
Copa Airlines
Deal found 5/1![Copa Airlines logo]()
$978
This American Airlines deal was found by Cheapflights users on 5/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 7/2010:44 am
AVL
- SCL
2 stops20h 16m
American Airlines
Tue 7/289:00 pm
SCL
- AVL
2 stops17h 19m
American Airlines
Deal found 5/2![American Airlines logo]()
$1,080
This United Airlines deal was found by Cheapflights users on 5/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 9/127:30 am
ILM
- SCL
2 stops43h 26m
United Airlines
Tue 9/225:14 am
SCL
- ILM
2 stops43h 36m
United Airlines
Deal found 5/4![United Airlines logo]()
$1,108
This eDestinos deal was found by Cheapflights users on 5/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure eDestinos is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 5/318:04 am
RDU
- SCL
1 stop21h 31m
LATAM Airlines
Mon 6/811:00 pm
SCL
- RDU
1 stop21h 44m
LATAM Airlines
Deal found 5/4![LATAM Airlines logo]()
$800
This Kiwi.com deal was found by Cheapflights users on 4/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 8/65:45 am
CLT
- SCL
1 stop25h 10m
Multiple Airlines
Mon 8/315:00 am
SCL
- CLT
2 stops36h 14m
Multiple Airlines
Deal found 4/30![Multiple Airlines logo]()
$844
This Delta deal was found by Cheapflights users on 5/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/1011:08 am
RDU
- SCL
2 stops17h 52m
Delta
Fri 10/167:45 am
SCL
- RDU
2 stops17h 38m
Delta
Deal found 5/1![Delta logo]()
$855
This FlightHub deal was found by Cheapflights users on 4/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure FlightHub is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 6/131:53 pm
RDU
- SCL
1 stop16h 32m
LATAM Airlines
Sat 6/276:00 pm
SCL
- RDU
2 stops26h 44m
LATAM Airlines
Deal found 4/30![LATAM Airlines logo]()
$819
This Delta deal was found by Cheapflights users on 5/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 6/55:56 pm
RDU
- SCL
1 stop13h 19m
Delta
Wed 6/178:40 pm
SCL
- RDU
1 stop17h 49m
Delta
Deal found 5/3![Delta logo]()
$855
This Kiwi.com deal was found by Cheapflights users on 5/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 8/115:45 am
CLT
- SCL
1 stop23h 50m
Multiple Airlines
Thu 8/278:20 pm
SCL
- CLT
2 stops43h 51m
Multiple Airlines
Deal found 5/1![Multiple Airlines logo]()
$888
This FlightHub deal was found by Cheapflights users on 5/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure FlightHub is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 9/1512:40 pm
RDU
- SCL
2 stops15h 55m
LATAM Airlines
Sun 9/205:40 am
SCL
- RDU
2 stops19h 47m
LATAM Airlines
Deal found 5/1![LATAM Airlines logo]()
$824
This Delta deal was found by Cheapflights users on 5/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 10/1111:08 am
RDU
- SCL
2 stops17h 52m
Delta
Fri 10/167:45 am
SCL
- RDU
2 stops17h 38m
Delta
Deal found 5/1![Delta logo]()
$855
This FlightHub deal was found by Cheapflights users on 5/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure FlightHub is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 10/1212:40 pm
RDU
- SCL
2 stops15h 55m
LATAM Airlines
Mon 10/194:10 am
SCL
- RDU
2 stops17h 46m
LATAM Airlines
Deal found 5/1![LATAM Airlines logo]()
$824
This American Airlines deal was found by Cheapflights users on 5/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 6/187:39 pm
ORF
- SCL
1 stop11h 26m
American Airlines
Thu 6/259:00 pm
SCL
- ORF
1 stop21h 59m
American Airlines
Deal found 5/4![American Airlines logo]()
$1,125
This United Airlines deal was found by Cheapflights users on 4/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/291:00 pm
MYR
- SCL
2 stops17h 50m
United Airlines
Mon 11/210:45 pm
SCL
- MYR
2 stops17h 48m
United Airlines
Deal found 4/30![United Airlines logo]()
$1,200
This Mytrip deal was found by Cheapflights users on 5/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 6/167:12 am
CLT
- SCL
3 stops22h 18m
Multiple Airlines
Sun 6/213:20 pm
SCL
- CLT
2 stops32h 23m
Multiple Airlines
Deal found 5/1![Multiple Airlines logo]()
$1,007
This LATAM Airlines deal was found by Cheapflights users on 4/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure LATAM Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 6/1410:00 am
RDU
- SCL
1 stop20h 25m
LATAM Airlines
Sun 6/2111:00 pm
SCL
- RDU
1 stop21h 44m
LATAM Airlines
Deal found 4/30![LATAM Airlines logo]()
$834
This American Airlines deal was found by Cheapflights users on 5/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 6/187:34 pm
TYS
- SCL
1 stop11h 31m
American Airlines
Thu 6/259:00 pm
SCL
- TYS
2 stops22h 33m
American Airlines
Deal found 5/4![American Airlines logo]()
$1,130
This Delta deal was found by Cheapflights users on 5/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/3012:00 pm
TYS
- SCL
1 stop19h 15m
Delta
Fri 10/98:40 pm
SCL
- TYS
1 stop13h 32m
Delta
Deal found 5/3![Delta logo]()
$1,005
This American Airlines deal was found by Cheapflights users on 5/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 6/187:00 am
TRI
- SCL
2 stops24h 05m
American Airlines
Thu 6/259:00 pm
SCL
- TRI
2 stops24h 57m
American Airlines
Deal found 5/4![American Airlines logo]()
$1,130
This Mytrip deal was found by Cheapflights users on 5/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 5/2212:29 pm
CLT
- SCL
2 stops17h 01m
Multiple Airlines
Tue 5/263:20 pm
SCL
- CLT
3 stops26h 24m
Multiple Airlines
Deal found 5/1![Multiple Airlines logo]()
$1,029
This United Airlines deal was found by Cheapflights users on 5/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/106:00 am
ILM
- SCL
2 stops40h 39m
United Airlines
Fri 10/161:44 am
SCL
- ILM
2 stops22h 12m
United Airlines
Deal found 5/4![United Airlines logo]()
$1,318
This Delta deal was found by Cheapflights users on 5/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 7/309:43 am
CLT
- SCL
2 stops20h 17m
Delta
Sat 8/810:55 pm
SCL
- CLT
1 stop24h 12m
Delta
Deal found 5/1![Delta logo]()
$1,025
This Trip.com deal was found by Cheapflights users on 5/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Trip.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 6/156:00 am
CLT
- SCL
3 stops44h 35m
Multiple Airlines
Mon 6/295:00 am
SCL
- CLT
3 stops40h 35m
Multiple Airlines
Deal found 5/3![Multiple Airlines logo]()
$1,052
This American Airlines deal was found by Cheapflights users on 4/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 5/282:27 pm
ORF
- SCL
2 stops16h 38m
American Airlines
Sun 6/289:00 pm
SCL
- ORF
2 stops16h 46m
American Airlines
Deal found 4/30![American Airlines logo]()
$1,180
This KAYAK deal was found by Cheapflights users on 4/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure KAYAK is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/307:07 am
TYS
- SCL
2 stops21h 53m
LATAM Airlines
Fri 10/97:15 am
SCL
- TYS
2 stops17h 31m
LATAM Airlines
Deal found 4/30![LATAM Airlines logo]()
$997
This United Airlines deal was found by Cheapflights users on 5/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 5/302:28 pm
GSO
- SCL
2 stops38h 42m
United Airlines
Fri 6/512:01 am
SCL
- GSO
2 stops23h 41m
United Airlines
Deal found 5/2![United Airlines logo]()
$1,358
This Kiwi.com deal was found by Cheapflights users on 5/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 5/301:14 pm
ORF
- SCL
1 stop31h 56m
Multiple Airlines
Fri 6/52:22 am
SCL
- ORF
2 stops20h 20m
Multiple Airlines
Deal found 5/1![Multiple Airlines logo]()
$1,057
Last-minute flights from North Carolina to SantiagoDiscover last-minute flight deals from North Carolina to Santiago. Data last updated May 5, 2026 and is based on user searches.
Discover last-minute flight deals from North Carolina to Santiago. Data last updated May 5, 2026 and is based on user searches.
This eDestinos deal was found by Cheapflights users on 5/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure eDestinos is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 5/207:58 pm
CLT
- SCL
2 stops27h 28m
Multiple Airlines
Thu 5/285:00 am
SCL
- CLT
2 stops36h 13m
Multiple Airlines
Deal found 5/2![Multiple Airlines logo]()
$857
This Mytrip deal was found by Cheapflights users on 5/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 5/2112:48 pm
CLT
- SCL
2 stops24h 42m
Multiple Airlines
Mon 5/253:20 pm
SCL
- CLT
2 stops32h 20m
Multiple Airlines
Deal found 5/1![Multiple Airlines logo]()
$796
This Mytrip deal was found by Cheapflights users on 5/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 5/2212:29 pm
CLT
- SCL
2 stops17h 01m
Multiple Airlines
Mon 5/253:20 pm
SCL
- CLT
2 stops32h 20m
Multiple Airlines
Deal found 5/1![Multiple Airlines logo]()
$933
This FlightHub deal was found by Cheapflights users on 4/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure FlightHub is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 5/255:56 pm
RDU
- SCL
1 stop13h 19m
LATAM Airlines
Sun 5/3110:55 pm
SCL
- RDU
1 stop15h 45m
LATAM Airlines
Deal found 4/30![LATAM Airlines logo]()
$837
This eDestinos deal was found by Cheapflights users on 5/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure eDestinos is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 5/302:32 pm
RDU
- SCL
3 stops39h 28m
Multiple Airlines
Sun 6/712:40 am
SCL
- RDU
2 stops41h 23m
Multiple Airlines
Deal found 5/4![Multiple Airlines logo]()
$730
This eDestinos deal was found by Cheapflights users on 5/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure eDestinos is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 5/318:09 am
RDU
- SCL
2 stops53h 21m
Multiple Airlines
Tue 6/23:35 am
SCL
- RDU
2 stops27h 49m
Multiple Airlines
Deal found 5/4![Multiple Airlines logo]()
$691
This eDestinos deal was found by Cheapflights users on 5/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure eDestinos is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 5/318:09 am
RDU
- SCL
2 stops53h 21m
Multiple Airlines
Mon 6/85:00 am
SCL
- RDU
2 stops37h 03m
Multiple Airlines
Deal found 5/4![Multiple Airlines logo]()
$696
This eDestinos deal was found by Cheapflights users on 5/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure eDestinos is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 5/318:04 am
RDU
- SCL
1 stop21h 31m
LATAM Airlines
Mon 6/811:00 pm
SCL
- RDU
1 stop21h 44m
LATAM Airlines
Deal found 5/4![LATAM Airlines logo]()
$800
This FlightHub deal was found by Cheapflights users on 5/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure FlightHub is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 6/38:04 am
RDU
- SCL
1 stop21h 31m
LATAM Airlines
Sun 6/1410:55 pm
SCL
- RDU
1 stop15h 26m
LATAM Airlines
Deal found 5/3![LATAM Airlines logo]()
$801
This eDestinos deal was found by Cheapflights users on 4/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure eDestinos is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 6/67:58 pm
CLT
- SCL
2 stops41h 37m
Multiple Airlines
Fri 6/125:00 am
SCL
- CLT
2 stops36h 14m
Multiple Airlines
Deal found 4/30![Multiple Airlines logo]()
$805
This FlightHub deal was found by Cheapflights users on 4/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure FlightHub is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 6/131:53 pm
RDU
- SCL
1 stop16h 32m
LATAM Airlines
Sat 6/276:00 pm
SCL
- RDU
2 stops26h 44m
LATAM Airlines
Deal found 4/30![LATAM Airlines logo]()
$819
This LATAM Airlines deal was found by Cheapflights users on 4/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure LATAM Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 6/1410:00 am
RDU
- SCL
1 stop20h 25m
LATAM Airlines
Sun 6/2111:00 pm
SCL
- RDU
1 stop21h 44m
LATAM Airlines
Deal found 4/30![LATAM Airlines logo]()
$834
One-way flights from North Carolina to SantiagoSearch for one-way flight options from North Carolina to Santiago. Find affordable one-way fares based on user searches. Data last updated May 5, 2026.
Search for one-way flight options from North Carolina to Santiago. Find affordable one-way fares based on user searches. Data last updated May 5, 2026.
This Kiwi.com deal was found by Cheapflights users on 5/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 5/197:58 pm
CLT
- SCL
2 stops50h 45m
Multiple Airlines
Deal found 5/1![Multiple Airlines logo]()
$315
This Kiwi.com deal was found by Cheapflights users on 5/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 5/314:45 pm
CLT
- SCL
3 stops42h 20m
Multiple Airlines
Deal found 5/1![Multiple Airlines logo]()
$335
This Kiwi.com deal was found by Cheapflights users on 5/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 9/58:09 am
RDU
- SCL
2 stops21h 26m
Multiple Airlines
Deal found 5/1![Multiple Airlines logo]()
$335
This Kiwi.com deal was found by Cheapflights users on 5/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 6/27:58 pm
CLT
- SCL
2 stops41h 37m
Multiple Airlines
Deal found 5/1![Multiple Airlines logo]()
$363
This Kiwi.com deal was found by Cheapflights users on 5/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 6/11:00 pm
CLT
- SCL
3 stops37h 35m
Multiple Airlines
Deal found 5/1![Multiple Airlines logo]()
$370
This eDestinos deal was found by Cheapflights users on 5/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure eDestinos is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 5/3110:15 pm
RDU
- SCL
2 stops39h 20m
Multiple Airlines
Deal found 5/4![Multiple Airlines logo]()
$375
This Kiwi.com deal was found by Cheapflights users on 5/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 5/207:58 pm
CLT
- SCL
2 stops26h 45m
Multiple Airlines
Deal found 5/1![Multiple Airlines logo]()
$398
This Kiwi.com deal was found by Cheapflights users on 5/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 6/1812:29 pm
CLT
- SCL
2 stops25h 06m
Multiple Airlines
Deal found 5/4![Multiple Airlines logo]()
$421
This Kiwi.com deal was found by Cheapflights users on 5/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 5/101:12 pm
CLT
- SCL
2 stops37h 08m
Multiple Airlines
Deal found 5/1![Multiple Airlines logo]()
$457
This Kiwi.com deal was found by Cheapflights users on 5/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 7/47:58 pm
CLT
- SCL
3 stops32h 47m
Multiple Airlines
Deal found 5/2![Multiple Airlines logo]()
$459
This eDestinos deal was found by Cheapflights users on 5/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure eDestinos is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 5/318:04 am
RDU
- SCL
1 stop21h 31m
LATAM Airlines
Deal found 5/4![LATAM Airlines logo]()
$569
This Delta deal was found by Cheapflights users on 5/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 7/315:48 am
ILM
- SCL
2 stops24h 12m
Delta
Deal found 5/4![Delta logo]()
$668
Find flight deals from North Carolina to Santiago
Keep the following information in mind while searching for North Carolina to Santiago flight deals. Data was last updated May 5, 2026.
Most accurate provider | FlightHub 3 stars |
|---|---|
Most trusted provider | FlightHub 3 stars |
Round-trip from | $691 (eDestinos) |
One-way from | $315 (Kiwi.com) |
Popular in | December |
Cheapest in | October |
Average price | $915 |
Cheapflights Fare Finder
Customize your flight search to find flights from North Carolina to Santiago that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated May 5, 2026.
Use the filters below to find and compare flights from North Carolina to Santiago that are best for you.
Fly from
Fly to
Route
Depart
Return
Cheapest round-trip
RaleighSantiago
RDU - SCL
RDUSCL
Raleigh-Durham
Sat 5/30
2:32 pm-6:00 am
3 stops39h 28m
Santiago Arturo Merino Benitez
Sun 6/7
12:40 am-6:03 pm
2 stops41h 23m
$730
RaleighSantiago
RDU - SCL
RDUSCL
Raleigh-Durham
Wed 10/7
10:00 am-6:25 am
1 stop19h 25m
Santiago Arturo Merino Benitez
Mon 11/2
11:05 pm-8:56 pm
1 stop23h 51m
$783
RaleighSantiago
RDU - SCL
RDUSCL
Raleigh-Durham
Sun 5/31
8:04 am-5:35 am
1 stop21h 31m
Santiago Arturo Merino Benitez
Mon 6/8
11:00 pm-8:44 pm
1 stop21h 44m
$800
RaleighSantiago
RDU - SCL
RDUSCL
Raleigh-Durham
Sat 6/13
1:53 pm-6:25 am
1 stop16h 32m
Santiago Arturo Merino Benitez
Sat 6/27
6:00 pm-8:44 pm
2 stops26h 44m
$819
RaleighSantiago
RDU - SCL
RDUSCL
Raleigh-Durham
Tue 9/15
12:40 pm-5:35 am
2 stops15h 55m
Santiago Arturo Merino Benitez
Sun 9/20
5:40 am-12:27 am
2 stops19h 47m
$824
RaleighSantiago
RDU - SCL
RDUSCL
Raleigh-Durham
Mon 10/12
12:40 pm-5:35 am
2 stops15h 55m
Santiago Arturo Merino Benitez
Mon 10/19
4:10 am-8:56 pm
2 stops17h 46m
$824
RaleighSantiago
RDU - SCL
RDUSCL
Raleigh-Durham
Sun 6/14
10:00 am-6:25 am
1 stop20h 25m
Santiago Arturo Merino Benitez
Sun 6/21
11:00 pm-8:44 pm
1 stop21h 44m
$834
CharlotteSantiago
CLT - SCL
CLTSCL
Charlotte Douglas
Thu 8/6
5:45 am-6:55 am
1 stop25h 10m
Santiago Arturo Merino Benitez
Mon 8/31
5:00 am-5:14 pm
2 stops36h 14m
$844
Quickest round-trip
RaleighSantiago
RDU - SCL
RDUSCL
Raleigh-Durham
Thu 6/4
5:56 pm-7:15 am
1 stop13h 19m
Santiago Arturo Merino Benitez
Sat 6/13
8:40 pm-12:44 pm
1 stop16h 04m
$855
RaleighSantiago
RDU - SCL
RDUSCL
Raleigh-Durham
Sat 10/10
11:08 am-6:00 am
2 stops17h 52m
Santiago Arturo Merino Benitez
Fri 10/16
7:45 am-12:23 am
2 stops17h 38m
$855
Showing 1-10 of 44 resultsSorted by cheapest first
Best time to book a flight from North Carolina to Santiago
Have a flexible travel schedule? Discover the best time to fly to Santiago from North Carolina with our price prediction graph.
CLT-SCL
RDU-SCL
ILM-SCL
AVL-SCL
ORF-SCL
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.
Cheapflights Insights
Everything you need to know about your flight from North Carolina to Santiago
USNC-SCL
CLT-SCL
RDU-SCL
ILM-SCL
AVL-SCL
What is the cheapest month to book a flight from North Carolina to Santiago?
Currently, July is the cheapest month in which you can book a flight from North Carolina to Santiago (average of $397). Flying from North Carolina to Santiago in June is currently the most expensive (average of $754). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.
How much does it cost to fly round-trip from North Carolina to Santiago?
Related info for your journey
Find useful and relevant information for your journey from North Carolina to Santiago. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.
Browse thousands of different options on Cheapflights for your next trip
Toggle through the tabs below to find thousands of options on Cheapflights for your next trip.
Alternative routes
Complete your trip
Flights by cabin class
Other flight options
Popular flights
Santiago flight routes
Top destinations
Alternative routes for North Carolina to Santiago
See prices for flight routes from nearby airports that may be better suited for you.
Complete your trip
Complete your trip to Santiago by adding a car rental and/or hotel reservation to your travel itinerary.
Search flights from North Carolina to Santiago by cabin class
Find flights from North Carolina to Santiago, based on your preferred cabin class, be it economy, premium economy, business, or first class.
North Carolina and Santiago flights
Browse other North Carolina and Santiago flight options. Last updated on May 5, 2026.
Popular flight searches
Check out other popular destinations found by fellow travelers in 2026
Other flights to Santiago
Explore flights to Santiago departing from other origins. Flights are based on user searches made on Cheapflights and were last updated on May 5, 2026.
North Carolina to Santiago flights
Consider these flights traveling from North Carolina to Santiago.
Top 3 airlines flying from North Carolina to Santiago
Discover the top 3 airlines that operate flights from North Carolina to Santiago. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated May 5, 2026.
| Airline | Cheapest | Average | Flexibility | On-time |
|---|---|---|---|---|
| Cheapest$402 | Average$955 | FlexibilityNo cancel fee | On-timeN/A | |
| Cheapest$505 | Average$876 | FlexibilityNo cancel fee | On-time71% | |
| Cheapest$634 | Average$863 | FlexibilityNo cancel fee | On-time81% |