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$330+ Cheap flights from Iowa to Santiago (SCL)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 5/2. Fares are subject to change and may not be available on all flights or dates of travel.
DSM — SCL
Feb 21 — Feb 281
Sat 2/21
Sat 2/28
1 adult, Economy
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Cheap flight deals from Iowa to Santiago

Cheapest flights from Iowa to Santiago
Explore the most affordable flight options available from Iowa to Santiago. Find the lowest fares from popular airlines and budget airlines, with prices last updated on January 22, 2026.

This Delta deal was found by Cheapflights users on 1/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 4/96:00 am
MLI
-
SCL
2 stops23h 00m
Delta
Wed 4/228:40 pm
SCL
-
MLI
1 stop14h 46m
Delta
Deal found 1/21$775
This Delta deal was found by Cheapflights users on 1/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 8/1011:04 am
DSM
-
SCL
1 stop19h 11m
Delta
Wed 8/198:40 pm
SCL
-
DSM
1 stop17h 42m
Delta
Deal found 1/20$825
This Delta deal was found by Cheapflights users on 1/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 8/96:30 pm
DSM
-
SCL
2 stops24h 15m
Delta
Mon 8/178:40 pm
SCL
-
DSM
1 stop14h 34m
Delta
Deal found 1/20$830
This KAYAK deal was found by Cheapflights users on 1/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure KAYAK is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 3/22:59 pm
DSM
-
SCL
1 stop14h 51m
Multiple Airlines
Mon 3/99:45 pm
SCL
-
DSM
1 stop18h 33m
Multiple Airlines
Deal found 1/20$841
This Bravofly deal was found by Cheapflights users on 1/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Bravofly is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 3/412:04 pm
DSM
-
SCL
1 stop16h 36m
LATAM Airlines
Wed 3/1110:10 pm
SCL
-
DSM
1 stop14h 38m
LATAM Airlines
Deal found 1/21$845
This KAYAK deal was found by Cheapflights users on 1/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure KAYAK is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 3/22:59 pm
DSM
-
SCL
1 stop14h 51m
Multiple Airlines
Wed 3/119:45 pm
SCL
-
DSM
2 stops17h 38m
Multiple Airlines
Deal found 1/20$846
This SmartFares deal was found by Cheapflights users on 1/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure SmartFares is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 3/25:24 am
DSM
-
SCL
1 stop23h 16m
LATAM Airlines
Mon 3/910:10 pm
SCL
-
DSM
1 stop14h 38m
LATAM Airlines
Deal found 1/19$851
This American Airlines deal was found by Cheapflights users on 1/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 3/41:38 pm
DSM
-
SCL
2 stops16h 52m
American Airlines
Wed 3/119:20 pm
SCL
-
DSM
2 stops17h 58m
American Airlines
Deal found 1/21$852
This Delta deal was found by Cheapflights users on 1/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 3/25:15 pm
DSM
-
SCL
2 stops32h 15m
Delta
Thu 3/1210:10 pm
SCL
-
DSM
1 stop20h 23m
Delta
Deal found 1/20$858
This KAYAK deal was found by Cheapflights users on 1/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure KAYAK is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 3/32:59 pm
DSM
-
SCL
1 stop14h 51m
Avianca
Mon 3/99:45 pm
SCL
-
DSM
2 stops17h 38m
Avianca
Deal found 1/20$860
This American Airlines deal was found by Cheapflights users on 1/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 5/66:00 am
MLI
-
SCL
2 stops23h 50m
American Airlines
Wed 5/208:30 pm
SCL
-
MLI
2 stops26h 27m
American Airlines
Deal found 1/21$863
This United Airlines deal was found by Cheapflights users on 1/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 3/16:55 pm
DSM
-
SCL
2 stops34h 55m
United Airlines
Wed 3/119:45 pm
SCL
-
DSM
1 stop18h 33m
United Airlines
Deal found 1/20$863

Find flight deals from Iowa to Santiago

Keep the following information in mind while searching for Iowa to Santiago flight deals. Data was last updated January 22, 2026.

Most accurate provider

FlightHub
3 stars

Most trusted provider

AranGrant
3 stars

Round-trip from

$775
(Delta)

One-way from

$330
(Kiwi.com)

Popular in

December

Cheapest in

October

Average price

$1,053
Provider with most accurate pricing for Des Moines-Santiago Arturo Merino Benitez flight deals.
Search Deals
Provider most trusted by Cheapflights users for Des Moines-Santiago Arturo Merino Benitez flights.
Search Deals
From Iowa to Santiago Arturo Merino Benitez
Search Deals
One-way flight from Iowa to Santiago Arturo Merino Benitez
Search Deals
Highest demand for flights based on searches. 6% potential increase in price ($72 potential increase over avg. RT price).
Search Deals
Cheapest flight prices on average. 5% potential price decrease ($58 potential savings vs. average RT price).
Search Deals
Average for round-trip flights in January 2026
Search Deals

Cheapflights Fare Finder

 
Customize your flight search to find flights from Iowa to Santiago that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated January 22, 2026.
Use the filters below to find and compare flights from Iowa to Santiago that are best for you.

Fly from

Iowa

Fly to

Santiago

Route

Depart

Return

Price

MolineSantiago

MLI - SCL

MLISCL

Moline Quad-City

Thu 4/9

6:00 am-6:00 am

2 stops23h 00m

Santiago Arturo Merino Benitez

Wed 4/22

8:40 pm-10:26 am

1 stop14h 46m

$775

Des MoinesSantiago

DSM - SCL

DSMSCL

Des Moines

Wed 3/4

12:04 pm-7:40 am

1 stop16h 36m

Santiago Arturo Merino Benitez

Wed 3/11

10:10 pm-10:48 am

1 stop14h 38m

$845

Des MoinesSantiago

DSM - SCL

DSMSCL

Des Moines

Wed 3/4

1:38 pm-9:30 am

2 stops16h 52m

Santiago Arturo Merino Benitez

Wed 3/11

9:20 pm-1:18 pm

2 stops17h 58m

$852

Des MoinesSantiago

DSM - SCL

DSMSCL

Des Moines

Thu 3/5

2:59 pm-8:50 am

1 stop14h 51m

Santiago Arturo Merino Benitez

Thu 3/12

9:45 pm-2:18 pm

1 stop18h 33m

$858

Des MoinesSantiago

DSM - SCL

DSMSCL

Des Moines

Thu 3/5

5:27 am-7:40 am

1 stop23h 13m

Santiago Arturo Merino Benitez

Wed 3/11

12:20 am-10:38 pm

2 stops24h 18m

$858

Des MoinesSantiago

DSM - SCL

DSMSCL

Des Moines

Mon 3/2

5:24 am-7:40 am

1 stop23h 16m

Santiago Arturo Merino Benitez

Mon 3/9

6:35 pm-4:33 pm

2 stops23h 58m

$858

Des MoinesSantiago

DSM - SCL

DSMSCL

Des Moines

Tue 3/3

5:24 am-7:40 am

1 stop23h 16m

Santiago Arturo Merino Benitez

Thu 3/12

10:10 pm-4:33 pm

1 stop20h 23m

$858

MolineSantiago

MLI - SCL

MLISCL

Moline Quad-City

Wed 5/6

6:00 am-6:50 am

2 stops23h 50m

Santiago Arturo Merino Benitez

Wed 5/20

8:30 pm-9:57 pm

2 stops26h 27m

$863

Des MoinesSantiago

DSM - SCL

DSMSCL

Des Moines

Thu 3/5

5:27 am-7:40 am

1 stop23h 13m

Santiago Arturo Merino Benitez

Tue 3/10

10:10 pm-4:33 pm

1 stop20h 23m

$873

Des MoinesSantiago

DSM - SCL

DSMSCL

Des Moines

Thu 3/5

5:27 am-7:40 am

1 stop23h 13m

Santiago Arturo Merino Benitez

Wed 3/11

10:10 pm-4:33 pm

1 stop20h 23m

$873

Flights are sorted by cheapest round-trip flights first.

Deals found on 1/22

Showing 1-10 of 35 results
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Best time to book a flight from Iowa to Santiago

Have a flexible travel schedule? Discover the best time to fly to Santiago from Iowa with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Iowa to Santiago
No data available for this route at this time. Please check back soon.

Related info for your journey

Find useful and relevant information for your journey from Iowa to Santiago. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airport do you fly into for flights to Santiago from Iowa?

    Most people fly into Santiago Arturo Merino Benitez (SCL) if they book a flight to Santiago from Iowa. Arturo Merino Benitez is conveniently located just 8.4 mi from Santiago’s city center.

  • How long is the flight from Iowa to Santiago?

    Airlines like Delta, LATAM Airlines, and American Airlines fly from Iowa to Santiago in about 16h 36m. The time it takes to get you to your destination can typically vary by up to 6h 24m. The distance between Iowa and Santiago is about 5374 mi. Both multi-stop and nonstop flights can be found to your destination and back.

  • What are the most popular routes from Iowa to Santiago?

    The most popular flight routes from Iowa to Santiago are Des Moines - Santiago Arturo Merino Benitez, Moline Quad-City - Santiago Arturo Merino Benitez and Cedar Rapids - Santiago Arturo Merino Benitez.

  • Can I find deals for flights from Iowa to Santiago that include hotel bookings?

    Yes. In addition to deals on Iowa to Santiago flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Iowa to Santiago?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Iowa to Santiago.

  • Can I find deals for business class flights from Iowa to Santiago?

    Yes. Cheapflights offers flight deals from Iowa to Santiago by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

See more FAQs

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Alternative routes for Iowa to Santiago

See prices for flight routes from nearby airports that may be better suited for you.
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Top airline flying from Iowa to Santiago

Discover the top airline that operate flights from Iowa to Santiago. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated January 22, 2026.
AirlineCheapestAverageFlexibilityOn-time
LATAM AirlinesCheapest$814Average$1,203FlexibilityNo cancel feeOn-time81%

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