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$1,000+ Cheap flights from Sioux Falls (FSD) to Santiago (SCL)

This is the cheapest round-trip flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 1/11. Fares are subject to change and may not be available on all flights or dates of travel.
FSD — SCL
Aug 31 — Sep 71
Mon 8/31
Mon 9/7
1 adult, Economy
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Cheap flight deals from Sioux Falls to Santiago

Best flights from Sioux Falls to Santiago
Discover carefully curated flight deals from Sioux Falls to Santiago that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated August 1, 2026.

This Delta deal was found by Cheapflights users on 7/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 1/115:25 am
FSD
-
SCL
2 stops20h 55m
Delta
Thu 1/2111:55 pm
SCL
-
FSD
2 stops18h 55m
Delta
Deal found 7/28$1,000
This American Airlines deal was found by Cheapflights users on 7/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 1/111:23 pm
FSD
-
SCL
1 stop15h 22m
American Airlines
Sun 1/2411:45 pm
SCL
-
FSD
1 stop16h 08m
American Airlines
Deal found 7/29$1,275
This Delta deal was found by Cheapflights users on 7/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 1/265:25 am
FSD
-
SCL
1 stop22h 15m
Delta
Mon 2/111:10 pm
SCL
-
FSD
1 stop26h 02m
Delta
Deal found 7/28$1,167
This American Airlines deal was found by Cheapflights users on 7/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 1/121:23 pm
FSD
-
SCL
1 stop15h 22m
American Airlines
Sun 1/2411:45 pm
SCL
-
FSD
1 stop16h 08m
American Airlines
Deal found 7/29$1,275
This American Airlines deal was found by Cheapflights users on 7/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 1/121:23 pm
FSD
-
SCL
1 stop15h 22m
American Airlines
Thu 1/2111:45 pm
SCL
-
FSD
1 stop16h 08m
American Airlines
Deal found 7/29$1,275
This Delta deal was found by Cheapflights users on 7/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 1/205:25 am
FSD
-
SCL
1 stop22h 15m
Delta
Sun 1/319:50 pm
SCL
-
FSD
1 stop27h 22m
Delta
Deal found 7/28$1,376
This American Airlines deal was found by Cheapflights users on 7/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 1/161:23 pm
FSD
-
SCL
1 stop15h 22m
American Airlines
Sun 1/2411:45 pm
SCL
-
FSD
1 stop16h 08m
American Airlines
Deal found 7/29$1,306
This Delta deal was found by Cheapflights users on 7/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 1/255:25 am
FSD
-
SCL
1 stop23h 15m
Delta
Sun 1/319:50 pm
SCL
-
FSD
1 stop27h 22m
Delta
Deal found 7/28$1,377
This Delta deal was found by Cheapflights users on 7/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 1/265:25 am
FSD
-
SCL
1 stop23h 15m
Delta
Sun 1/319:50 pm
SCL
-
FSD
1 stop27h 22m
Delta
Deal found 7/28$1,377
This American Airlines deal was found by Cheapflights users on 7/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 1/121:23 pm
FSD
-
SCL
1 stop15h 22m
American Airlines
Fri 1/2211:45 pm
SCL
-
FSD
1 stop16h 08m
American Airlines
Deal found 7/29$1,395
This American Airlines deal was found by Cheapflights users on 7/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 1/151:23 pm
FSD
-
SCL
1 stop15h 22m
American Airlines
Fri 1/2211:45 pm
SCL
-
FSD
1 stop16h 08m
American Airlines
Deal found 7/29$1,395
This Delta deal was found by Cheapflights users on 7/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 1/265:25 am
FSD
-
SCL
1 stop22h 15m
Delta
Sat 1/3011:00 pm
SCL
-
FSD
1 stop26h 12m
Delta
Deal found 7/28$1,493

Find flight deals from Sioux Falls to Santiago

Discover tips and strategies to find the most affordable flight options for your journey from Sioux Falls (FSD) to Santiago (SCL). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated August 1, 2026.

Most accurate provider

Ovago
3 stars

Most trusted provider

Ovago
3 stars

Round-trip from

$995
(Delta)
Provider with most accurate pricing for Sioux Falls Joe Foss Field-Santiago Arturo Merino Benitez flight deals.
Search Deals
Provider most trusted by Cheapflights users for Sioux Falls Joe Foss Field-Santiago Arturo Merino Benitez flights.
Search Deals
From Sioux Falls Joe Foss Field to Santiago Arturo Merino Benitez
Search Deals

Cheapflights Fare Finder

 
Customize your flight search to find flights from Sioux Falls to Santiago that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated August 1, 2026.
Use the filters below to find and compare flights from Sioux Falls to Santiago that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Cheapest round-trip

Sioux FallsSantiago

FSD - SCL

FSDSCL

Sioux Falls Joe Foss Field

Mon 1/11

5:25 am-5:20 am

2 stops20h 55m

Santiago Arturo Merino Benitez

Thu 1/21

11:55 pm-3:50 pm

2 stops18h 55m

$1,000

Sioux FallsSantiago

FSD - SCL

FSDSCL

Sioux Falls Joe Foss Field

Tue 1/26

5:25 am-6:40 am

1 stop22h 15m

Santiago Arturo Merino Benitez

Mon 2/1

11:10 pm-10:12 pm

1 stop26h 02m

$1,167
Quickest round-trip

Sioux FallsSantiago

FSD - SCL

FSDSCL

Sioux Falls Joe Foss Field

Mon 1/11

1:23 pm-7:45 am

1 stop15h 22m

Santiago Arturo Merino Benitez

Sun 1/24

11:45 pm-12:53 pm

1 stop16h 08m

$1,275

Sioux FallsSantiago

FSD - SCL

FSDSCL

Sioux Falls Joe Foss Field

Tue 1/12

1:23 pm-7:45 am

1 stop15h 22m

Santiago Arturo Merino Benitez

Sun 1/24

11:45 pm-12:53 pm

1 stop16h 08m

$1,275

Sioux FallsSantiago

FSD - SCL

FSDSCL

Sioux Falls Joe Foss Field

Tue 1/12

1:23 pm-7:45 am

1 stop15h 22m

Santiago Arturo Merino Benitez

Thu 1/21

11:45 pm-12:53 pm

1 stop16h 08m

$1,275

Sioux FallsSantiago

FSD - SCL

FSDSCL

Sioux Falls Joe Foss Field

Sat 1/16

1:23 pm-7:45 am

1 stop15h 22m

Santiago Arturo Merino Benitez

Sun 1/24

11:45 pm-12:53 pm

1 stop16h 08m

$1,306

Sioux FallsSantiago

FSD - SCL

FSDSCL

Sioux Falls Joe Foss Field

Wed 1/20

5:25 am-6:40 am

1 stop22h 15m

Santiago Arturo Merino Benitez

Sun 1/31

9:50 pm-10:12 pm

1 stop27h 22m

$1,376

Sioux FallsSantiago

FSD - SCL

FSDSCL

Sioux Falls Joe Foss Field

Mon 1/25

5:25 am-7:40 am

1 stop23h 15m

Santiago Arturo Merino Benitez

Sun 1/31

9:50 pm-10:12 pm

1 stop27h 22m

$1,377

Sioux FallsSantiago

FSD - SCL

FSDSCL

Sioux Falls Joe Foss Field

Tue 1/26

5:25 am-7:40 am

1 stop23h 15m

Santiago Arturo Merino Benitez

Sun 1/31

9:50 pm-10:12 pm

1 stop27h 22m

$1,377

Sioux FallsSantiago

FSD - SCL

FSDSCL

Sioux Falls Joe Foss Field

Tue 1/12

1:23 pm-7:45 am

1 stop15h 22m

Santiago Arturo Merino Benitez

Fri 1/22

11:45 pm-12:53 pm

1 stop16h 08m

$1,395

Flights are sorted by cheapest round-trip flights first.

Deals found on 7/28

Showing 1-10 of 12 resultsSorted by cheapest first
1
2
  • Most accurate provider: When it comes to deals on Sioux Falls-Santiago flights, users find the pricing of Ovago to be most consistent on Cheapflights vs. Ovago Users can find the same prices on Sioux Falls-Santiago flight deals on Cheapflights vs. Ovago >95% of the time. Price accuracy is based on data collected from Sioux Falls-Santiago flight searches over the past month and is updated monthly.
  • Most trusted provider: When it comes to deals on Sioux Falls-Santiago flights, Cheapflights users trust Ovago the most. Ovago has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for Sioux Falls-Santiago flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.

Best time to book a flight from Sioux Falls to Santiago

Have a flexible travel schedule? Discover the best time to fly to Santiago from Sioux Falls with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Related info for your journey

Find useful and relevant information for your journey from Sioux Falls to Santiago. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • How long is the flight from Sioux Falls to Santiago?

    A quick flight from Sioux Falls to Santiago can take about 20h 55m. Delta provides one of the quickest options available for as low as $995. Sioux Falls and Santiago are separated by a distance of 5561 mi. This flight may include one or multiple stops.

  • Can I find deals for flights from Sioux Falls to Santiago that include hotel bookings?

    Yes. In addition to deals on Sioux Falls to Santiago flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Sioux Falls to Santiago?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Sioux Falls to Santiago.

  • Can I find deals for business class flights from Sioux Falls to Santiago?

    Yes. Cheapflights offers flight deals from Sioux Falls to Santiago by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

See more FAQs

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