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$342+ Cheap flights from Sioux Falls (FSD) to Santiago (SCL)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 10/19. Fares are subject to change and may not be available on all flights or dates of travel.
FSD — SCL
Aug 10 — Aug 171
Mon 8/10
Mon 8/17
1 adult, Economy
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Cheap flight deals from Sioux Falls to Santiago

One-way flights from Sioux Falls to Santiago
Search for one-way flight options from Sioux Falls to Santiago. Find affordable one-way fares based on user searches. Data last updated July 11, 2026.

This Kiwi.com deal was found by Cheapflights users on 7/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 10/198:44 pm
FSD
-
SCL
3 stops53h 12m
Multiple Airlines
Deal found 7/7$342
This Kiwi.com deal was found by Cheapflights users on 7/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/217:31 pm
FSD
-
SCL
3 stops32h 39m
Multiple Airlines
Deal found 7/7$460
This Kiwi.com deal was found by Cheapflights users on 7/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 10/1812:26 pm
FSD
-
SCL
3 stops33h 13m
Multiple Airlines
Deal found 7/7$504
This Kiwi.com deal was found by Cheapflights users on 7/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/167:31 pm
FSD
-
SCL
3 stops54h 25m
Multiple Airlines
Deal found 7/7$511
This Kiwi.com deal was found by Cheapflights users on 7/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/2211:46 am
FSD
-
SCL
3 stops40h 24m
Multiple Airlines
Deal found 7/7$512
This Kiwi.com deal was found by Cheapflights users on 7/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/177:31 pm
FSD
-
SCL
3 stops49h 05m
Multiple Airlines
Deal found 7/7$534
This Delta deal was found by Cheapflights users on 7/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 10/205:10 am
FSD
-
SCL
2 stops23h 15m
Delta
Deal found 7/7$628
This Delta deal was found by Cheapflights users on 7/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 10/195:30 am
FSD
-
SCL
1 stop24h 45m
Delta
Deal found 7/7$647
This Delta deal was found by Cheapflights users on 7/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/175:00 pm
FSD
-
SCL
2 stops58h 35m
Delta
Deal found 7/7$661
This Delta deal was found by Cheapflights users on 7/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/165:10 am
FSD
-
SCL
2 stops22h 25m
Delta
Deal found 7/7$678

Find flight deals from Sioux Falls to Santiago

Discover tips and strategies to find the most affordable flight options for your journey from Sioux Falls (FSD) to Santiago (SCL). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated July 11, 2026.

Most accurate provider

Ovago
3 stars

Most trusted provider

Ovago
3 stars
Provider with most accurate pricing for Sioux Falls Joe Foss Field-Santiago Arturo Merino Benitez flight deals.
Search Deals
Provider most trusted by Cheapflights users for Sioux Falls Joe Foss Field-Santiago Arturo Merino Benitez flights.
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Cheapflights Fare Finder

 
Customize your flight search to find flights from Sioux Falls to Santiago that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated July 11, 2026.
Use the filters below to find and compare flights from Sioux Falls to Santiago that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Cheapest one-way

Sioux FallsSantiago

FSD - SCL

FSDSCL

Sioux Falls Joe Foss Field

Tue 10/20

5:10 am-6:25 am

2 stops23h 15m

$628

Sioux FallsSantiago

FSD - SCL

FSDSCL

Sioux Falls Joe Foss Field

Mon 10/19

5:30 am-5:35 am

2 stops22h 05m

$628
Quickest one-way

Sioux FallsSantiago

FSD - SCL

FSDSCL

Sioux Falls Joe Foss Field

Thu 10/22

8:30 am-6:25 am

2 stops19h 55m

$628

Sioux FallsSantiago

FSD - SCL

FSDSCL

Sioux Falls Joe Foss Field

Fri 10/16

5:10 am-5:35 am

2 stops22h 25m

$678

Sioux FallsSantiago

FSD - SCL

FSDSCL

Sioux Falls Joe Foss Field

Sun 10/18

5:30 am-8:15 am

1 stop24h 45m

$697

Flights are sorted by cheapest round-trip flights first.

Deals found on 7/7

Sorted by cheapest first
  • Most accurate provider: When it comes to deals on Sioux Falls-Santiago flights, users find the pricing of Ovago to be most consistent on Cheapflights vs. Ovago Users can find the same prices on Sioux Falls-Santiago flight deals on Cheapflights vs. Ovago >95% of the time. Price accuracy is based on data collected from Sioux Falls-Santiago flight searches over the past month and is updated monthly.
  • Most trusted provider: When it comes to deals on Sioux Falls-Santiago flights, Cheapflights users trust Ovago the most. Ovago has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for Sioux Falls-Santiago flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.

Best time to book a flight from Sioux Falls to Santiago

Have a flexible travel schedule? Discover the best time to fly to Santiago from Sioux Falls with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Related info for your journey

Find useful and relevant information for your journey from Sioux Falls to Santiago. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • Can I find deals for flights from Sioux Falls to Santiago that include hotel bookings?

    Yes. In addition to deals on Sioux Falls to Santiago flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Sioux Falls to Santiago?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Sioux Falls to Santiago.

  • Can I find deals for business class flights from Sioux Falls to Santiago?

    Yes. Cheapflights offers flight deals from Sioux Falls to Santiago by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

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Complete your trip

Complete your trip to Santiago by adding a car rental and/or hotel reservation to your travel itinerary.
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