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$405+ Cheap flights from Des Moines (DSM) to Santiago (SCL)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 7/25. Fares are subject to change and may not be available on all flights or dates of travel.
DSM — SCL
Jun 17 — Jun 241
Tue 6/17
Tue 6/24
1 adult, Economy
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Cheap flight deals from Des Moines to Santiago

Discover tips and strategies to find the most affordable flight options for your journey from Des Moines (DSM) to Santiago (SCL). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated June 12, 2025.

Round-trip from

$870
(Delta)

One-way from

$405
(Kiwi.com)

Popular in

December

Cheapest in

October

Average price

$1,243
From Des Moines to Santiago Arturo Merino Benitez
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One-way flight from Des Moines to Santiago Arturo Merino Benitez
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Highest demand for flights based on searches. 7% potential increase in price ($93 potential increase over avg. RT price).
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Cheapest flight prices on average. 5% potential price decrease ($54 potential savings vs. average RT price).
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Average for round-trip flights in June 2025
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Find flight deals from Des Moines to Santiago

Cheapest flights from Des Moines to Santiago
Explore the most affordable flight options available from Des Moines to Santiago. Find the lowest fares from popular airlines and budget airlines, with prices last updated on June 12, 2025.

This Delta deal was found by Cheapflights users on 6/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 8/122:12 pmDSM - SCL
1 stop15h 48mDelta
Mon 8/188:40 pmSCL - DSM
1 stop14h 58mDelta
Deal found 6/10$870
This LATAM Airlines deal was found by Cheapflights users on 6/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure LATAM Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 8/112:12 pmDSM - SCL
2 stops15h 38mLATAM Airlines
Thu 8/1411:00 amSCL - DSM
2 stops24h 10mLATAM Airlines
Deal found 6/9$874
This United Airlines deal was found by Cheapflights users on 6/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 12/238:00 amDSM - SCL
2 stops45h 50mUnited Airlines
Mon 1/1210:45 pmSCL - DSM
1 stop26h 45mUnited Airlines
Deal found 6/12$1,084
This Mytrip deal was found by Cheapflights users on 6/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 7/243:44 pmDSM - SCL
3 stops35h 33mMultiple Airlines
Thu 7/316:10 amSCL - DSM
3 stops36h 55mMultiple Airlines
Deal found 6/10$1,137
This American Airlines deal was found by Cheapflights users on 6/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 12/235:00 amDSM - SCL
1 stop23h 50mAmerican Airlines
Mon 1/1211:15 pmSCL - DSM
1 stop20h 03mAmerican Airlines
Deal found 6/12$1,210
This Avianca deal was found by Cheapflights users on 6/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Avianca is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 8/128:00 amDSM - SCL
2 stops19h 15mAvianca
Wed 8/132:30 pmSCL - DSM
2 stops32h 17mAvianca
Deal found 6/9$1,331
This Iberia deal was found by Cheapflights users on 6/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Iberia is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 8/101:22 pmDSM - SCL
2 stops54h 28mIberia
Sun 8/174:15 pmSCL - DSM
2 stops32h 12mIberia
Deal found 6/9$2,964
This KAYAK deal was found by Cheapflights users on 6/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure KAYAK is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 8/107:20 pmDSM - SCL
2 stops62h 40mQantas Airways
Fri 8/1512:40 amSCL - DSM
3 stops43h 00mQantas Airways
Deal found 6/9$30,194

Cheapflights Fare Finder

Customize your flight search to find flights from Des Moines to Santiago that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated June 12, 2025.
Use the filters below to find and compare flights from Des Moines to Santiago that are best for you.

Fly from

Des Moines

Fly to

Santiago

Route

Depart

Return

Price

Des MoinesSantiago

DSM - SCL

DSMSCL

Des Moines

Tue 8/12

2:12 pm-7:00 am

1 stop15h 48m

Santiago Arturo Merino Benitez

Mon 8/18

8:40 pm-10:38 am

1 stop14h 58m

$870

Des MoinesSantiago

DSM - SCL

DSMSCL

Des Moines

Mon 8/11

2:12 pm-6:50 am

2 stops15h 38m

Santiago Arturo Merino Benitez

Thu 8/14

11:00 am-10:10 am

2 stops24h 10m

$874

Des MoinesSantiago

DSM - SCL

DSMSCL

Des Moines

Thu 7/24

3:44 pm-4:17 am

3 stops35h 33m

Santiago Arturo Merino Benitez

Thu 7/31

6:10 am-6:05 pm

3 stops36h 55m

$1,137

Des MoinesSantiago

DSM - SCL

DSMSCL

Des Moines

Sat 7/26

7:09 am-7:05 am

2 stops22h 56m

Santiago Arturo Merino Benitez

Sat 8/2

9:50 pm-7:35 pm

2 stops22h 45m

$1,222

Des MoinesSantiago

DSM - SCL

DSMSCL

Des Moines

Tue 8/12

8:00 am-4:15 am

2 stops19h 15m

Santiago Arturo Merino Benitez

Wed 8/13

2:30 pm-9:47 pm

2 stops32h 17m

$1,331

Des MoinesSantiago

DSM - SCL

DSMSCL

Des Moines

Sun 8/10

1:22 pm-8:50 pm

2 stops54h 28m

Santiago Arturo Merino Benitez

Sun 8/17

4:15 pm-11:27 pm

2 stops32h 12m

$2,964

Des MoinesSantiago

DSM - SCL

DSMSCL

Des Moines

Sun 8/10

7:20 pm-11:00 am

2 stops62h 40m

Santiago Arturo Merino Benitez

Fri 8/15

12:40 am-6:40 pm

3 stops43h 00m

$30,194

Des MoinesSantiago

DSM - SCL

DSMSCL

Des Moines

Fri 7/25

6:30 am-4:15 am

3 stops44h 45m

$405

Des MoinesSantiago

DSM - SCL

DSMSCL

Des Moines

Fri 7/25

5:30 am-7:00 am

1 stop24h 30m

$594

Des MoinesSantiago

DSM - SCL

DSMSCL

Des Moines

Tue 6/17

2:20 pm-7:00 am

1 stop15h 40m

$668

Flights are sorted by cheapest round-trip flights first.

Deals found on 6/10

Best time to book a flight from Des Moines to Santiago

Have a flexible travel schedule? Discover the best time to fly to Santiago from Des Moines with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Des Moines to Santiago

Rainfall in Santiago by month

Plan your trip to Santiago by taking into account the average rainfall totals by month.

In terms of precipitation, rainfall in Santiago ranges from 0.0 - 2.8 inches per month. June is typically the wettest month, when rainfall can reach 2.8 in. January is typically the driest time to visit Santiago when rainfall is around 0.0 in.

Temperature in Santiago by month

Plan your trip to Santiago by taking into account the average temperature totals by month.

If weather is an important factor for your trip to Santiago, use this chart to help with planning. For those seeking warmer temperatures, January is the ideal time of year to visit, when temperatures reach an average of 69.8 F. Travelers looking to avoid the cold should look outside of June, when temperatures are typically at their lowest (around 46.4 F).

Reviews of airlines servicing Santiago

Get insights into the airlines that provide service to Santiago. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Santiago. Reviews last updated June 12, 2025.
Delta
8.0
Very good
7,946 reviews

Food

7.3

Entertainment

7.9

Boarding

8.2

Overall

8.0

Comfort

7.9

Crew

8.5

Reviews

1 / 20
10.0
Excellent

Kim,May 2025

PIH - SLC

This trip was fine even with delay I had plenty of time to get connection flight!
Delta
8.0
Very good
7,946 reviews
Delta
8.0
Very good
7,946 reviews

Food

7.3

Entertainment

7.9

Boarding

8.2

Overall

8.0

Comfort

7.9

Crew

8.5

Reviews

1 / 20
10.0
Excellent

Kim,May 2025

PIH - SLC

This trip was fine even with delay I had plenty of time to get connection flight!
LATAM Airlines
7.5
Good
1,785 reviews
Delta
8.0
Very good
7,946 reviews

Food

7.3

Entertainment

7.9

Boarding

8.2

Overall

8.0

Comfort

7.9

Crew

8.5

Reviews

1 / 20
10.0
Excellent

Kim,May 2025

PIH - SLC

This trip was fine even with delay I had plenty of time to get connection flight!
Qantas Airways
7.5
Good
854 reviews
Delta
8.0
Very good
7,946 reviews

Food

7.3

Entertainment

7.9

Boarding

8.2

Overall

8.0

Comfort

7.9

Crew

8.5

Reviews

1 / 20
10.0
Excellent

Kim,May 2025

PIH - SLC

This trip was fine even with delay I had plenty of time to get connection flight!
American Airlines
7.2
Good
10,000 reviews
Delta
8.0
Very good
7,946 reviews

Food

7.3

Entertainment

7.9

Boarding

8.2

Overall

8.0

Comfort

7.9

Crew

8.5

Reviews

1 / 20
10.0
Excellent

Kim,May 2025

PIH - SLC

This trip was fine even with delay I had plenty of time to get connection flight!
Iberia
7.0
Good
2,776 reviews
Delta
8.0
Very good
7,946 reviews

Food

7.3

Entertainment

7.9

Boarding

8.2

Overall

8.0

Comfort

7.9

Crew

8.5

Reviews

1 / 20
10.0
Excellent

Kim,May 2025

PIH - SLC

This trip was fine even with delay I had plenty of time to get connection flight!

Related info for your journey

Find useful and relevant information for your journey from Des Moines to Santiago. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What are the cheapest airlines flying from Des Moines to Santiago round-trip?

    Currently priced at $870, Delta will fly you from Des Moines to Santiago and back. In addition to Delta, many other airlines offer competitively priced options for your trip. Search Cheapflights for deals from LATAM Airlines and American Airlines - these airlines can fly you to your destination from $874 and $1,222, respectively. Delta is 19% cheaper than the average price of flights available within the next 90 days to this destination.

  • Can I find deals for flights from Des Moines to Santiago that include hotel bookings?

    Yes. In addition to deals on Des Moines to Santiago flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Des Moines to Santiago?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Des Moines to Santiago.

  • Can I find deals for business class flights from Des Moines to Santiago?

    Yes. Cheapflights offers flight deals from Des Moines to Santiago by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Des Moines to Santiago?

    Currently, April is the cheapest month in which you can book a flight from Des Moines to Santiago (average of $752). Flying from Des Moines to Santiago in December is currently the most expensive (average of $1,098). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Browse thousands of different options on Cheapflights for your next trip

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Alternative routes for Des Moines to Santiago

See prices for flight routes from nearby airports that may be better suited for you.
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Top 2 airlines flying from Des Moines to Santiago

Discover the top 2 airlines that operate flights from Des Moines to Santiago. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated June 12, 2025.
AirlineCheapestAverageFlexibilityOn-time
American AirlinesCheapest$742Average$1,558FlexibilityNo cancel feeOn-time71%
DeltaCheapest$782Average$932FlexibilityNo cancel feeOn-timeN/A

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