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$413+ Cheap flights from Des Moines (DSM) to Santiago (SCL)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 3/30. Fares are subject to change and may not be available on all flights or dates of travel.
DSM — SCL
Mar 18 — Mar 251
Wed 3/18
Wed 3/25
1 adult, Economy
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Cheap flight deals from Des Moines to Santiago

Cheapest flights from Des Moines to Santiago
Explore the most affordable flight options available from Des Moines to Santiago. Find the lowest fares from popular airlines and budget airlines, with prices last updated on February 16, 2026.

This Bravofly deal was found by Cheapflights users on 2/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Bravofly is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 3/315:20 pm
DSM
-
SCL
1 stop12h 55m
LATAM Airlines
Tue 4/78:40 pm
SCL
-
DSM
1 stop15h 08m
LATAM Airlines
Deal found 2/14$812
This Bravofly deal was found by Cheapflights users on 2/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Bravofly is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 3/305:20 pm
DSM
-
SCL
2 stops18h 20m
LATAM Airlines
Mon 4/68:40 pm
SCL
-
DSM
1 stop15h 08m
LATAM Airlines
Deal found 2/13$813
This American Airlines deal was found by Cheapflights users on 2/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 3/311:48 pm
DSM
-
SCL
2 stops16h 02m
American Airlines
Tue 4/78:35 pm
SCL
-
DSM
2 stops18h 11m
American Airlines
Deal found 2/14$849
This American Airlines deal was found by Cheapflights users on 2/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 3/301:52 pm
DSM
-
SCL
2 stops15h 58m
American Airlines
Mon 4/68:25 pm
SCL
-
DSM
2 stops17h 27m
American Airlines
Deal found 2/13$850
This LATAM Airlines deal was found by Cheapflights users on 2/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure LATAM Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 4/111:33 am
DSM
-
SCL
2 stops25h 02m
LATAM Airlines
Wed 4/87:15 am
SCL
-
DSM
2 stops28h 33m
LATAM Airlines
Deal found 2/15$852
This Delta deal was found by Cheapflights users on 2/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 3/315:35 am
DSM
-
SCL
2 stops22h 15m
Delta
Tue 4/77:45 pm
SCL
-
DSM
2 stops21h 48m
Delta
Deal found 2/14$858
This Delta deal was found by Cheapflights users on 2/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 4/110:28 am
DSM
-
SCL
2 stops18h 07m
Delta
Wed 4/811:25 pm
SCL
-
DSM
2 stops22h 45m
Delta
Deal found 2/14$863

Find flight deals from Des Moines to Santiago

Discover tips and strategies to find the most affordable flight options for your journey from Des Moines (DSM) to Santiago (SCL). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated February 16, 2026.

Most accurate provider

FlightHub
3 stars

Most trusted provider

FlightHub
3 stars

Round-trip from

$812
(Bravofly)

One-way from

$413
(American Airlines)

Popular in

December

Cheapest in

October
Provider with most accurate pricing for Des Moines-Santiago Arturo Merino Benitez flight deals.
Search Deals
Provider most trusted by Cheapflights users for Des Moines-Santiago Arturo Merino Benitez flights.
Search Deals
From Des Moines to Santiago Arturo Merino Benitez
Search Deals
One-way flight from Des Moines to Santiago Arturo Merino Benitez
Search Deals
Highest demand for flights based on searches. 1% potential increase in price ($17 potential increase over avg. RT price).
Search Deals
Cheapest flight prices on average. 5% potential price decrease ($57 potential savings vs. average RT price).
Search Deals

Cheapflights Fare Finder

 
Customize your flight search to find flights from Des Moines to Santiago that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated February 16, 2026.
Use the filters below to find and compare flights from Des Moines to Santiago that are best for you.

Fly from

Des Moines

Fly to

Santiago

Route

Depart

Return

Price

Des MoinesSantiago

DSM - SCL

DSMSCL

Des Moines

Mon 3/30

5:20 pm-8:15 am

1 stop12h 55m

Santiago Arturo Merino Benitez

Mon 4/6

8:40 pm-10:48 am

1 stop15h 08m

$812

Des MoinesSantiago

DSM - SCL

DSMSCL

Des Moines

Tue 3/31

11:33 am-5:50 am

2 stops16h 17m

Santiago Arturo Merino Benitez

Tue 4/7

8:40 pm-10:48 am

1 stop15h 08m

$812

Des MoinesSantiago

DSM - SCL

DSMSCL

Des Moines

Tue 3/31

1:48 pm-7:50 am

2 stops16h 02m

Santiago Arturo Merino Benitez

Tue 4/7

8:35 pm-1:46 pm

2 stops18h 11m

$849

Des MoinesSantiago

DSM - SCL

DSMSCL

Des Moines

Mon 3/30

1:52 pm-7:50 am

2 stops15h 58m

Santiago Arturo Merino Benitez

Mon 4/6

8:25 pm-12:52 pm

2 stops17h 27m

$850

Des MoinesSantiago

DSM - SCL

DSMSCL

Des Moines

Wed 4/1

5:20 pm-8:15 am

1 stop12h 55m

Santiago Arturo Merino Benitez

Wed 4/8

9:10 pm-10:48 am

2 stops38h 38m

$852

Des MoinesSantiago

DSM - SCL

DSMSCL

Des Moines

Wed 4/1

11:33 am-2:35 pm

2 stops25h 02m

Santiago Arturo Merino Benitez

Wed 4/8

7:15 am-10:48 am

2 stops28h 33m

$852

Des MoinesSantiago

DSM - SCL

DSMSCL

Des Moines

Mon 3/30

1:48 pm-7:50 am

2 stops16h 02m

$413

Des MoinesSantiago

DSM - SCL

DSMSCL

Des Moines

Mon 3/30

5:20 pm-8:15 am

1 stop12h 55m

$417

Des MoinesSantiago

DSM - SCL

DSMSCL

Des Moines

Mon 3/30

11:33 am-1:40 pm

3 stops24h 07m

$418

Flights are sorted by cheapest round-trip flights first.

Deals found on 2/13

Compare providers for flights from Des Moines to Santiago

Provider information is updated monthly. Please note that these providers often have deals for this flight, but the availability may vary on a day-by-day basis on Cheapflights.
Use the table below to compare price accuracy, trust ratings, and cancellation policies for each provider offering flight deals from Des Moines to Santiago in February.
ProviderPrice AccuracyTrust Score*
FlightHubPrice Accuracy3 starsTrust Score*3 stars
AranGrantPrice Accuracy2 starsTrust Score*2 stars

*The Trust Score is based on feedback from users after their booking experience. It measures overall satisfaction, helping us identify issues like hidden fees, problems during the ticketing process, and the quality of customer service. This score is our best indicator of the provider's quality and reliability.

  • Most accurate provider: When it comes to deals on Des Moines-Santiago flights, users find the pricing of FlightHub to be most consistent on Cheapflights vs. FlightHub Users can find the same prices on Des Moines-Santiago flight deals on Cheapflights vs. FlightHub >95% of the time. Price accuracy is based on data collected from Des Moines-Santiago flight searches over the past month and is updated monthly.
  • Most trusted provider: When it comes to deals on Des Moines-Santiago flights, Cheapflights users trust FlightHub the most. FlightHub has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for Des Moines-Santiago flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.

Best time to book a flight from Des Moines to Santiago

Have a flexible travel schedule? Discover the best time to fly to Santiago from Des Moines with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Reviews of airlines servicing Santiago

Get insights into the airlines that provide service to Santiago. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Santiago. Reviews last updated February 16, 2026.
Read through reviews of airlines operating flights from Des Moines to Santiago, such as LATAM Airlines. Reviews also offer insight into each airline's entertainment options, comfort, food, crew/service, and boarding process.
LATAM Airlines
7.5
Good
1,919 reviews

Overall

7.5

Boarding

7.5

Comfort

7.3

Entertainment

7.0

Food

6.7

Crew

8.0

Reviews

1 / 20
2.0
Mediocre

Jess,Jan 2026

GRU - MIA

sat on the tarmac for 4.5 hours with no explanation, climate control, honesty about the timeline or the situation, or even letting anyone off. The crew was passive-aggressive and sneaky, trying to skirt legal time limits requiring financial restitution for passengers, pretending the "flight had started" even though they didn't budge for another 40 minutes. One of the worst flights I've ever taken
LATAM Airlines
7.5
Good
1,919 reviews
LATAM Airlines
7.5
Good
1,919 reviews

Overall

7.5

Boarding

7.5

Comfort

7.3

Entertainment

7.0

Food

6.7

Crew

8.0

Reviews

1 / 20
2.0
Mediocre

Jess,Jan 2026

GRU - MIA

sat on the tarmac for 4.5 hours with no explanation, climate control, honesty about the timeline or the situation, or even letting anyone off. The crew was passive-aggressive and sneaky, trying to skirt legal time limits requiring financial restitution for passengers, pretending the "flight had started" even though they didn't budge for another 40 minutes. One of the worst flights I've ever taken

Related info for your journey

Find useful and relevant information for your journey from Des Moines to Santiago. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • How long is the flight from Des Moines to Santiago?

    There are many flights that can get you from Des Moines to Santiago in 12h 55m. Fly via LATAM Airlines to get the fastest option. Des Moines and Santiago are separated by a distance of 5374 mi.

  • What is the cheapest airline to fly from Des Moines to Santiago round-trip?

    Currently priced at $814, LATAM Airlines will fly you from Des Moines to Santiago and back. In addition to LATAM Airlines, many other airlines offer competitively priced options for your trip. LATAM Airlines is 28% cheaper than the average price of flights available within the next 90 days to this destination.

  • Can I find deals for flights from Des Moines to Santiago that include hotel bookings?

    Yes. In addition to deals on Des Moines to Santiago flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Des Moines to Santiago?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Des Moines to Santiago.

  • Can I find deals for business class flights from Des Moines to Santiago?

    Yes. Cheapflights offers flight deals from Des Moines to Santiago by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

See more FAQs

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Alternative routes for Des Moines to Santiago

See prices for flight routes from nearby airports that may be better suited for you.
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Top airline flying from Des Moines to Santiago

Discover the top airline that operate flights from Des Moines to Santiago. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated February 16, 2026.
AirlineCheapestAverageFlexibilityOn-time
LATAM AirlinesCheapest$814Average$1,203FlexibilityNo cancel feeOn-time81%

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