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$543+ Cheap flights from Des Moines (DSM) to Santiago (SCL)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 11/19. Fares are subject to change and may not be available on all flights or dates of travel.
DSM — SCL
Nov 5 — Nov 121
Wed 11/5
Wed 11/12
1 adult, Economy
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Cheap flight deals from Des Moines to Santiago

Discover tips and strategies to find the most affordable flight options for your journey from Des Moines (DSM) to Santiago (SCL). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated October 6, 2025.

Most accurate provider

FlightHub
3 stars

Most trusted provider

FlightHub
3 stars

Round-trip from

$761
(LATAM Airlines)

One-way from

$543
(LATAM Airlines)

Popular in

December

Cheapest in

October

Average price

$814
Provider with most accurate pricing for Des Moines-Santiago Arturo Merino Benitez flight deals.
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Provider most trusted by Cheapflights users for Des Moines-Santiago Arturo Merino Benitez flights.
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From Des Moines to Santiago Arturo Merino Benitez
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One-way flight from Des Moines to Santiago Arturo Merino Benitez
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Highest demand for flights based on searches. 15% potential increase in price ($207 potential increase over avg. RT price).
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Cheapest flight prices on average. 5% potential price decrease ($57 potential savings vs. average RT price).
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Average for round-trip flights in October 2025
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Find flight deals from Des Moines to Santiago

Cheapest flights from Des Moines to Santiago
Explore the most affordable flight options available from Des Moines to Santiago. Find the lowest fares from popular airlines and budget airlines, with prices last updated on October 6, 2025.

This LATAM Airlines deal was found by Cheapflights users on 10/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure LATAM Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 11/192:17 pmDSM - SCL
1 stop14h 23mLATAM Airlines
Wed 11/265:15 amSCL - DSM
2 stops20h 18mLATAM Airlines
Deal found 10/5$761
This Delta deal was found by Cheapflights users on 10/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 11/185:35 amDSM - SCL
1 stop23h 05mDelta
Tue 11/2511:10 pmSCL - DSM
1 stop14h 32mDelta
Deal found 10/4$764
This United Airlines deal was found by Cheapflights users on 10/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 11/196:05 amDSM - SCL
1 stop23h 45mUnited Airlines
Wed 11/2610:45 pmSCL - DSM
2 stops18h 34mUnited Airlines
Deal found 10/5$769
This Delta deal was found by Cheapflights users on 10/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 12/76:33 pmDSM - SCL
1 stop34h 07mDelta
Wed 12/2411:10 pmSCL - DSM
1 stop16h 18mDelta
Deal found 10/6$773
This United Airlines deal was found by Cheapflights users on 10/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 11/21:05 pmDSM - SCL
2 stops40h 45mUnited Airlines
Mon 11/1010:45 pmSCL - DSM
1 stop18h 26mUnited Airlines
Deal found 10/5$784
This Orbitz deal was found by Cheapflights users on 10/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Orbitz is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 11/22:13 pmDSM - SCL
2 stops53h 37mLATAM Airlines
Sun 11/94:35 amSCL - DSM
2 stops20h 58mLATAM Airlines
Deal found 10/5$803
This Delta deal was found by Cheapflights users on 10/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/2210:50 amDSM - SCL
2 stops17h 55mDelta
Fri 10/316:30 pmSCL - DSM
2 stops24h 00mDelta
Deal found 10/4$804
This United Airlines deal was found by Cheapflights users on 10/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 12/128:15 amDSM - SCL
1 stop21h 35mUnited Airlines
Wed 12/2410:45 pmSCL - DSM
2 stops18h 48mUnited Airlines
Deal found 10/6$809

Cheapflights Fare Finder

 
Customize your flight search to find flights from Des Moines to Santiago that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated October 6, 2025.
Use the filters below to find and compare flights from Des Moines to Santiago that are best for you.

Fly from

Des Moines

Fly to

Santiago

Route

Depart

Return

Price

Des MoinesSantiago

DSM - SCL

DSMSCL

Des Moines

Wed 11/19

2:17 pm-7:40 am

1 stop14h 23m

Santiago Arturo Merino Benitez

Wed 11/26

5:15 am-10:33 pm

2 stops20h 18m

$761

Des MoinesSantiago

DSM - SCL

DSMSCL

Des Moines

Tue 11/18

2:17 pm-7:40 am

1 stop14h 23m

Santiago Arturo Merino Benitez

Mon 11/24

12:50 am-10:33 pm

2 stops24h 43m

$764

Des MoinesSantiago

DSM - SCL

DSMSCL

Des Moines

Tue 11/4

2:13 pm-3:30 pm

2 stops22h 17m

Santiago Arturo Merino Benitez

Tue 11/11

11:10 pm-10:42 am

1 stop14h 32m

$764

Des MoinesSantiago

DSM - SCL

DSMSCL

Des Moines

Wed 11/19

11:28 am-7:40 am

1 stop17h 12m

Santiago Arturo Merino Benitez

Wed 11/26

11:10 pm-12:15 pm

1 stop16h 05m

$764

Des MoinesSantiago

DSM - SCL

DSMSCL

Des Moines

Wed 12/10

5:34 am-6:35 am

2 stops22h 01m

Santiago Arturo Merino Benitez

Wed 12/24

6:30 pm-12:28 pm

2 stops20h 58m

$764

Des MoinesSantiago

DSM - SCL

DSMSCL

Des Moines

Thu 11/20

5:35 am-6:35 am

2 stops22h 00m

Santiago Arturo Merino Benitez

Wed 11/26

8:55 am-12:15 pm

2 stops30h 20m

$764

Des MoinesSantiago

DSM - SCL

DSMSCL

Des Moines

Tue 11/4

2:13 pm-7:40 am

1 stop14h 27m

Santiago Arturo Merino Benitez

Wed 11/12

11:10 pm-10:42 am

1 stop14h 32m

$764

Des MoinesSantiago

DSM - SCL

DSMSCL

Des Moines

Tue 12/9

5:34 am-7:40 am

1 stop23h 06m

Santiago Arturo Merino Benitez

Wed 12/24

11:10 pm-12:28 pm

1 stop16h 18m

$764

Des MoinesSantiago

DSM - SCL

DSMSCL

Des Moines

Wed 11/19

2:17 pm-3:30 pm

2 stops22h 13m

$543

Flights are sorted by cheapest round-trip flights first.

Deals found on 10/5

Compare providers for flights from Des Moines to Santiago

Provider information is updated monthly. Please note that these providers often have deals for this flight, but the availability may vary on a day-by-day basis on Cheapflights.
Use the table below to compare price accuracy, trust ratings, and cancellation policies for each provider offering flight deals from Des Moines to Santiago in October.
ProviderPrice AccuracyTrust Score*
eDreamsPrice Accuracy3 starsTrust Score*3 stars
FlightHubPrice Accuracy3 starsTrust Score*3 stars
AranGrantPrice Accuracy3 starsTrust Score*3 stars

*The Trust Score is based on feedback from users after their booking experience. It measures overall satisfaction, helping us identify issues like hidden fees, problems during the ticketing process, and the quality of customer service. This score is our best indicator of the provider's quality and reliability.

  • Most accurate provider: When it comes to deals on Des Moines-Santiago flights, users find the pricing of FlightHub to be most consistent on Cheapflights vs. FlightHub Users can find the same prices on Des Moines-Santiago flight deals on Cheapflights vs. FlightHub >95% of the time. Price accuracy is based on data collected from Des Moines-Santiago flight searches over the past month and is updated monthly.
  • Most trusted provider: When it comes to deals on Des Moines-Santiago flights, Cheapflights users trust FlightHub the most. FlightHub has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for Des Moines-Santiago flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.

Best time to book a flight from Des Moines to Santiago

Have a flexible travel schedule? Discover the best time to fly to Santiago from Des Moines with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Reviews of airlines servicing Santiago

Get insights into the airlines that provide service to Santiago. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Santiago. Reviews last updated October 6, 2025.
Read through reviews of airlines operating flights from Des Moines to Santiago, such as LATAM Airlines. Reviews also offer insight into each airline's entertainment options, comfort, food, crew/service, and boarding process.
LATAM Airlines
7.5
Good
1,861 reviews

Crew

8.0

Comfort

7.4

Entertainment

7.0

Food

6.7

Boarding

7.6

Overall

7.5

Reviews

1 / 20
2.0
Mediocre

Anonymous,Oct 2025

MIA - GRU

Terrible baggage service! Almost lost my connection flight in SP
LATAM Airlines
7.5
Good
1,861 reviews
LATAM Airlines
7.5
Good
1,861 reviews

Crew

8.0

Comfort

7.4

Entertainment

7.0

Food

6.7

Boarding

7.6

Overall

7.5

Reviews

1 / 20
2.0
Mediocre

Anonymous,Oct 2025

MIA - GRU

Terrible baggage service! Almost lost my connection flight in SP

Related info for your journey

Find useful and relevant information for your journey from Des Moines to Santiago. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • How long is the flight from Des Moines to Santiago?

    There are many flights that can get you from Des Moines to Santiago in 14h 23m. Fly via LATAM Airlines or Delta to get the fastest option. Des Moines and Santiago are separated by a distance of 5374 mi.

  • What is the cheapest airline to fly from Des Moines to Santiago round-trip?

    Currently priced at $843, LATAM Airlines will fly you from Des Moines to Santiago and back. In addition to LATAM Airlines, many other airlines offer competitively priced options for your trip. LATAM Airlines is 26% cheaper than the average price of flights available within the next 90 days to this destination.

  • Can I find deals for flights from Des Moines to Santiago that include hotel bookings?

    Yes. In addition to deals on Des Moines to Santiago flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Des Moines to Santiago?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Des Moines to Santiago.

  • Can I find deals for business class flights from Des Moines to Santiago?

    Yes. Cheapflights offers flight deals from Des Moines to Santiago by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Des Moines to Santiago?

    Currently, April is the cheapest month in which you can book a flight from Des Moines to Santiago (average of $752). Flying from Des Moines to Santiago in December is currently the most expensive (average of $1,098). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

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Alternative routes for Des Moines to Santiago

See prices for flight routes from nearby airports that may be better suited for you.
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Top airline flying from Des Moines to Santiago

Discover the top airline that operate flights from Des Moines to Santiago. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated October 6, 2025.
AirlineCheapestAverageFlexibilityOn-time
LATAM AirlinesCheapest$843Average$1,203FlexibilityNo cancel feeOn-time81%

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