What are the cheapest airlines flying from Des Moines to Santiago round-trip?

Currently priced at $742, American Airlines will fly you from Des Moines to Santiago and back. In addition to American Airlines, many other airlines offer competitively priced options for your trip. Search Cheapflights for deals from Delta and LATAM Airlines - these airlines can fly you to your destination from $782 and $843, respectively. American Airlines is 29% cheaper than the average price of flights available within the next 90 days to this destination.

What is the cheapest month to book a flight from Des Moines to Santiago?

Currently, April is the cheapest month in which you can book a flight from Des Moines to Santiago (average of $752). Flying from Des Moines to Santiago in December is currently the most expensive (average of $1,098). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest day to fly from Des Moines to Santiago?

Travelers seeking maximum savings on their Des Moines to Santiago flight should consider departing on Tuesday at noon when fares are most often at their lowest. Thursday mornings flights should be avoided if possible as fares are typically the most expensive at this time.

In terms of precipitation, rainfall in Santiago ranges from 0.0 - 2.8 inches per month. June is typically the wettest month, when rainfall can reach 2.8 in. January is typically the driest time to visit Santiago when rainfall is around 0.0 in.

If weather is an important factor for your trip to Santiago, use this chart to help with planning. For those seeking warmer temperatures, January is the ideal time of year to visit, when temperatures reach an average of 69.8 F. Travelers looking to avoid the cold should look outside of June, when temperatures are typically at their lowest (around 46.4 F).

What are the most popular airlines that fly from Des Moines to Santiago?

The most popular airlines flying from Des Moines to Santiago are American Airlines, Delta and LATAM Airlines. Something to consider prior to booking your flight.

What is the cheapest day to fly round-trip from Des Moines to Santiago?

Travelers have found that booking a Monday departure is the best way to save up to 76% on the cost of booking your flights compared to booking on days of the week where this route is of high demand.

What is the cheapest month to fly from Des Moines to Santiago?

November can be a great time to fly to Santiago from Des Moines with a flight ticket averaging about $1,057. Cheapflights users have found deals in the month of November for as cheap as $742. The most expensive prices can be found in the month of December.

What is the cheapest time of day to fly from DSM to SCL?

Unlike in the morning, when flights are generally more expensive, you can save up to 29% on flights from Des Moines to Santiago by exploring options for tickets in the afternoon.

Can I find deals for flights from Des Moines to Santiago that include hotel bookings?

Yes. In addition to deals on Des Moines to Santiago flights, Cheapflights offers vacation packages that include both flights and hotel.

How can I find direct flights from Des Moines to Santiago?

After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Des Moines to Santiago.

Can I find deals for business class flights from Des Moines to Santiago?

Yes. Cheapflights offers flight deals from Des Moines to Santiago by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

$776+ Cheap Flights from Des Moines to Santiago

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Cheap flight deals from Des Moines to Santiago

Round-trip from	$776 (Mytrip)
Popular in	December
Cheapest in	November
Average price	$1,007

From Des Moines to Santiago Arturo Merino Benitez

Search Deals

Highest demand for flights based on searches. 2% potential increase in price ($25 potential increase over avg. RT price).

Search Deals

Cheapest flight prices on average. 5% potential price decrease ($54 potential savings vs. average RT price).

Search Deals

Average for round-trip flights in August 2025

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Find flight deals from Des Moines to Santiago

Cheapest flights from Des Moines to Santiago
Explore the most affordable flight options available from Des Moines to Santiago. Find the lowest fares from popular airlines and budget airlines, with prices last updated on August 14, 2025.

Sun 9/284:38 pmDSM - SCL

3 stops33h 39mMultiple Airlines

Sun 10/53:30 pmSCL - DSM

3 stops27h 31mMultiple Airlines

Deal found 8/14

$776

Mon 12/82:14 pmDSM - SCL

1 stop13h 46mDelta

Fri 12/1211:15 pmSCL - DSM

1 stop14h 03mDelta

Deal found 8/12

$824

Sun 9/284:09 pmDSM - SCL

1 stop12h 51mLATAM Airlines

Sun 10/54:35 pmSCL - DSM

2 stops31h 55mLATAM Airlines

Deal found 8/14

$834

Sun 9/286:30 pmDSM - SCL

2 stops18h 30mDelta

Sun 10/59:40 pmSCL - DSM

1 stop22h 04mDelta

Deal found 8/14

$864

Best flights from Des Moines to Santiago
Discover carefully curated flight deals from Des Moines to Santiago that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated August 14, 2025.

Sun 9/284:38 pmDSM - SCL

3 stops33h 39mMultiple Airlines

Sun 10/53:30 pmSCL - DSM

3 stops27h 31mMultiple Airlines

Deal found 8/14

$776

Mon 12/82:14 pmDSM - SCL

1 stop13h 46mDelta

Fri 12/1211:15 pmSCL - DSM

1 stop14h 03mDelta

Deal found 8/12

$824

Mon 12/85:45 amDSM - SCL

2 stops19h 45mLATAM Airlines

Thu 12/114:35 amSCL - DSM

2 stops20h 48mLATAM Airlines

Deal found 8/12

$824

Sun 9/284:09 pmDSM - SCL

1 stop12h 51mLATAM Airlines

Sun 10/54:35 pmSCL - DSM

2 stops31h 55mLATAM Airlines

Deal found 8/14

$834

Last-minute flights from Des Moines to Santiago
Discover last-minute flight deals from Des Moines to Santiago. Data last updated August 14, 2025 and is based on user searches.

Sat 9/275:12 pmDSM - SCL

2 stops18h 08mLATAM Airlines

Fri 10/312:25 amSCL - DSM

2 stops24h 12mLATAM Airlines

Deal found 8/13

$903

Sun 9/284:38 pmDSM - SCL

3 stops33h 39mMultiple Airlines

Sun 10/53:30 pmSCL - DSM

3 stops27h 31mMultiple Airlines

Deal found 8/14

$776

Sun 9/284:09 pmDSM - SCL

1 stop12h 51mLATAM Airlines

Sun 10/54:35 pmSCL - DSM

2 stops31h 55mLATAM Airlines

Deal found 8/14

$834

Sun 9/286:30 pmDSM - SCL

2 stops18h 30mDelta

Sun 10/59:40 pmSCL - DSM

1 stop22h 04mDelta

Deal found 8/14

$864

Cheapflights Fare Finder

Use the filters below to find and compare flights from Des Moines to Santiago that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Des MoinesSantiago

DSM - SCL

DSMSCL

Des Moines

Sun 9/28

4:38 pm-4:17 am

3 stops33h 39m

Santiago Arturo Merino Benitez

Sun 10/5

3:30 pm-5:01 pm

3 stops27h 31m

$776

Des MoinesSantiago

DSM - SCL

DSMSCL

Des Moines

Mon 12/8

2:14 pm-7:00 am

1 stop13h 46m

Santiago Arturo Merino Benitez

Fri 12/12

11:15 pm-10:18 am

1 stop14h 03m

$824

Des MoinesSantiago

DSM - SCL

DSMSCL

Des Moines

Mon 12/8

5:45 am-4:30 am

2 stops19h 45m

Santiago Arturo Merino Benitez

Thu 12/11

4:35 am-10:23 pm

2 stops20h 48m

$824

Des MoinesSantiago

DSM - SCL

DSMSCL

Des Moines

Sun 9/28

4:09 pm-7:00 am

1 stop12h 51m

Santiago Arturo Merino Benitez

Sun 10/5

4:35 pm-10:30 pm

2 stops31h 55m

$834

Flights are sorted by cheapest round-trip flights first.

Deals found on 8/14

Best time to book a flight from Des Moines to Santiago

Have a flexible travel schedule? Discover the best time to fly to Santiago from Des Moines with our price prediction graph.

Estimated round-trip price

Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Reviews of airlines servicing Santiago

Read through reviews of airlines operating flights from Des Moines to Santiago, such as Delta, LATAM Airlines, and American Airlines. Reviews also offer insight into each airline's entertainment options, comfort, food, crew/service, and boarding process.

Delta

8.0

Very good

7,980 reviews

Reviews

1 / 20

10.0

Excellent

Kim,May 2025

PIH - SLC

This trip was fine even with delay I had plenty of time to get connection flight!

Delta

8.0

Very good

7,980 reviews

Delta

8.0

Very good

7,980 reviews

Reviews

1 / 20

10.0

Excellent

Kim,May 2025

PIH - SLC

This trip was fine even with delay I had plenty of time to get connection flight!

LATAM Airlines

7.5

Good

1,840 reviews

Delta

8.0

Very good

7,980 reviews

Reviews

1 / 20

10.0

Excellent

Kim,May 2025

PIH - SLC

This trip was fine even with delay I had plenty of time to get connection flight!

American Airlines

7.2

Good

10,000 reviews

Delta

8.0

Very good

7,980 reviews

Reviews

1 / 20

10.0

Excellent

Kim,May 2025

PIH - SLC

This trip was fine even with delay I had plenty of time to get connection flight!

Related info for your journey

What are the cheapest airlines flying from Des Moines to Santiago round-trip?
Currently priced at $742, American Airlines will fly you from Des Moines to Santiago and back. In addition to American Airlines, many other airlines offer competitively priced options for your trip. Search Cheapflights for deals from Delta and LATAM Airlines - these airlines can fly you to your destination from $782 and $843, respectively. American Airlines is 29% cheaper than the average price of flights available within the next 90 days to this destination.
Can I find deals for flights from Des Moines to Santiago that include hotel bookings?
Yes. In addition to deals on Des Moines to Santiago flights, Cheapflights offers vacation packages that include both flights and hotel.
How can I find direct flights from Des Moines to Santiago?
After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Des Moines to Santiago.
Can I find deals for business class flights from Des Moines to Santiago?
Yes. Cheapflights offers flight deals from Des Moines to Santiago by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.
What is the cheapest month to book a flight from Des Moines to Santiago?
Currently, April is the cheapest month in which you can book a flight from Des Moines to Santiago (average of $752). Flying from Des Moines to Santiago in December is currently the most expensive (average of $1,098). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Browse thousands of different options on Cheapflights for your next trip

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Other flights to Santiago

Top 3 airlines flying from Des Moines to Santiago

Airline	Cheapest	Average	Flexibility	On-time
American Airlines	Cheapest$742	Average$1,558	FlexibilityNo cancel fee	On-time71%
Delta	Cheapest$782	Average$958	FlexibilityNo cancel fee	On-timeN/A
LATAM Airlines	Cheapest$843	Average$1,203	FlexibilityNo cancel fee	On-time81%

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$776+ Cheap flights from Des Moines (DSM) to Santiago (SCL)

This is the cheapest round-trip flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 9/28. Fares are subject to change and may not be available on all flights or dates of travel.

Find cheap flights from Des Moines to Santiago with Cheapflights

1. Tell us where you want to go

2. Select your favorite providers

3. Compare prices and book

Cheap flight deals from Des Moines to Santiago

Round-trip from

Popular in

Cheapest in

Average price

Find flight deals from Des Moines to Santiago

Cheapest flights from Des Moines to SantiagoExplore the most affordable flight options available from Des Moines to Santiago. Find the lowest fares from popular airlines and budget airlines, with prices last updated on August 14, 2025.

Explore the most affordable flight options available from Des Moines to Santiago. Find the lowest fares from popular airlines and budget airlines, with prices last updated on August 14, 2025.

Cheapflights Fare Finder

Use the filters below to find and compare flights from Des Moines to Santiago that are best for you.

Best time to book a flight from Des Moines to Santiago

Have a flexible travel schedule? Discover the best time to fly to Santiago from Des Moines with our price prediction graph.

Reviews of airlines servicing Santiago

Read through reviews of airlines operating flights from Des Moines to Santiago, such as Delta, LATAM Airlines, and American Airlines. Reviews also offer insight into each airline's entertainment options, comfort, food, crew/service, and boarding process.

Related info for your journey

Find useful and relevant information for your journey from Des Moines to Santiago. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

What are the cheapest airlines flying from Des Moines to Santiago round-trip?

Can I find deals for flights from Des Moines to Santiago that include hotel bookings?

How can I find direct flights from Des Moines to Santiago?

Can I find deals for business class flights from Des Moines to Santiago?

What is the cheapest month to book a flight from Des Moines to Santiago?

Browse thousands of different options on Cheapflights for your next trip

Toggle through the tabs below to find thousands of options on Cheapflights for your next trip.

Alternative routes for Des Moines to Santiago

See prices for flight routes from nearby airports that may be better suited for you.

Top 3 airlines flying from Des Moines to Santiago

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Book with Flexibility

Travel Smart

Cheapest flights from Des Moines to Santiago
Explore the most affordable flight options available from Des Moines to Santiago. Find the lowest fares from popular airlines and budget airlines, with prices last updated on August 14, 2025.