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$761+ Cheap flights from Des Moines (DSM) to Santiago (SCL)

This is the cheapest round-trip flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 2/9. Fares are subject to change and may not be available on all flights or dates of travel.
DSM — SCL
Feb 4 — Feb 111
Wed 2/4
Wed 2/11
1 adult, Economy
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Cheap flight deals from Des Moines to Santiago

Cheapest flights from Des Moines to Santiago
Explore the most affordable flight options available from Des Moines to Santiago. Find the lowest fares from popular airlines and budget airlines, with prices last updated on January 5, 2026.

This American Airlines deal was found by Cheapflights users on 1/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 2/911:35 amDSM - SCL
1 stop17h 40mAmerican Airlines
Mon 2/1611:15 pmSCL - DSM
1 stop21h 13mAmerican Airlines
Deal found 1/3$761
This Delta deal was found by Cheapflights users on 1/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 2/186:19 amDSM - SCL
2 stops22h 21mDelta
Wed 2/2511:10 pmSCL - DSM
2 stops25h 10mDelta
Deal found 1/4$770
This Gurufare deal was found by Cheapflights users on 1/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Gurufare is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 11/113:00 pmDSM - SCL
1 stop14h 50mAvianca
Wed 11/2510:45 pmSCL - DSM
1 stop18h 35mAvianca
Deal found 1/3$804
This KAYAK deal was found by Cheapflights users on 1/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure KAYAK is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 11/116:30 pmDSM - SCL
2 stops16h 35mLATAM Airlines
Tue 11/244:10 amSCL - DSM
2 stops21h 19mLATAM Airlines
Deal found 1/3$805
This United Airlines deal was found by Cheapflights users on 1/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 2/178:00 amDSM - SCL
2 stops21h 50mUnited Airlines
Tue 2/2410:45 pmSCL - DSM
2 stops25h 56mUnited Airlines
Deal found 1/2$820
This Ovago deal was found by Cheapflights users on 1/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Ovago is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 2/205:15 pmDSM - SCL
1 stop35h 25mLATAM Airlines
Sun 2/226:30 pmSCL - DSM
2 stops30h 58mLATAM Airlines
Deal found 1/4$840
This United Airlines deal was found by Cheapflights users on 1/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 2/187:52 amDSM - SCL
1 stop21h 58mUnited Airlines
Wed 2/2510:45 pmSCL - DSM
1 stop26h 35mUnited Airlines
Deal found 1/4$876
This LATAM Airlines deal was found by Cheapflights users on 1/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure LATAM Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/26:30 pmDSM - SCL
2 stops20h 55mLATAM Airlines
Tue 10/611:05 pmSCL - DSM
2 stops20h 37mLATAM Airlines
Deal found 1/4$911

Find flight deals from Des Moines to Santiago

Discover tips and strategies to find the most affordable flight options for your journey from Des Moines (DSM) to Santiago (SCL). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated January 5, 2026.

Most accurate provider

eDreams
3 stars

Most trusted provider

eDreams
3 stars

Round-trip from

$761
(American Airlines)

Popular in

December

Cheapest in

October

Average price

$1,053
Provider with most accurate pricing for Des Moines-Santiago Arturo Merino Benitez flight deals.
Search Deals
Provider most trusted by Cheapflights users for Des Moines-Santiago Arturo Merino Benitez flights.
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From Des Moines to Santiago Arturo Merino Benitez
Search Deals
Highest demand for flights based on searches. 6% potential increase in price ($72 potential increase over avg. RT price).
Search Deals
Cheapest flight prices on average. 5% potential price decrease ($58 potential savings vs. average RT price).
Search Deals
Average for round-trip flights in January 2026
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Cheapflights Fare Finder

 
Customize your flight search to find flights from Des Moines to Santiago that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated January 5, 2026.
Use the filters below to find and compare flights from Des Moines to Santiago that are best for you.

Fly from

Des Moines

Fly to

Santiago

Route

Depart

Return

Price

Des MoinesSantiago

DSM - SCL

DSMSCL

Des Moines

Mon 2/9

11:35 am-8:15 am

1 stop17h 40m

Santiago Arturo Merino Benitez

Mon 2/16

11:15 pm-5:28 pm

1 stop21h 13m

$761

Des MoinesSantiago

DSM - SCL

DSMSCL

Des Moines

Wed 2/18

6:19 am-7:40 am

2 stops22h 21m

Santiago Arturo Merino Benitez

Wed 2/25

8:15 am-10:28 pm

2 stops17h 13m

$770

Des MoinesSantiago

DSM - SCL

DSMSCL

Des Moines

Tue 2/17

7:52 am-8:50 am

1 stop21h 58m

Santiago Arturo Merino Benitez

Tue 2/24

10:45 pm-9:41 pm

2 stops25h 56m

$820

Des MoinesSantiago

DSM - SCL

DSMSCL

Des Moines

Wed 2/18

7:52 am-8:50 am

1 stop21h 58m

Santiago Arturo Merino Benitez

Wed 2/25

10:45 pm-10:20 pm

1 stop26h 35m

$876

Des MoinesSantiago

DSM - SCL

DSMSCL

Des Moines

Fri 2/20

11:46 am-2:05 pm

2 stops23h 19m

Santiago Arturo Merino Benitez

Sun 2/22

8:50 pm-10:28 pm

2 stops28h 38m

$888

Flights are sorted by cheapest round-trip flights first.

Deals found on 1/3

Compare providers for flights from Des Moines to Santiago

Provider information is updated monthly. Please note that these providers often have deals for this flight, but the availability may vary on a day-by-day basis on Cheapflights.
Use the table below to compare price accuracy, trust ratings, and cancellation policies for each provider offering flight deals from Des Moines to Santiago in January.
ProviderPrice AccuracyTrust Score*
eDreamsPrice Accuracy3 starsTrust Score*3 stars
FlightHubPrice Accuracy3 starsTrust Score*1 star
AranGrantPrice Accuracy2 starsTrust Score*3 stars

*The Trust Score is based on feedback from users after their booking experience. It measures overall satisfaction, helping us identify issues like hidden fees, problems during the ticketing process, and the quality of customer service. This score is our best indicator of the provider's quality and reliability.

  • Most accurate provider: When it comes to deals on Des Moines-Santiago flights, users find the pricing of eDreams to be most consistent on Cheapflights vs. eDreams Users can find the same prices on Des Moines-Santiago flight deals on Cheapflights vs. eDreams >95% of the time. Price accuracy is based on data collected from Des Moines-Santiago flight searches over the past month and is updated monthly.
  • Most trusted provider: When it comes to deals on Des Moines-Santiago flights, Cheapflights users trust eDreams the most. eDreams has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for Des Moines-Santiago flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.

Best time to book a flight from Des Moines to Santiago

Have a flexible travel schedule? Discover the best time to fly to Santiago from Des Moines with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Des Moines to Santiago

How much does it cost to fly round-trip from Des Moines to Santiago?

Reviews of airlines servicing Santiago

Get insights into the airlines that provide service to Santiago. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Santiago. Reviews last updated January 5, 2026.
Read through reviews of airlines operating flights from Des Moines to Santiago, such as LATAM Airlines. Reviews also offer insight into each airline's entertainment options, comfort, food, crew/service, and boarding process.
LATAM Airlines
7.5
Good
1,900 reviews

Overall

7.5

Boarding

7.6

Comfort

7.3

Crew

8.0

Food

6.7

Entertainment

7.0

Reviews

1 / 20
2.0
Mediocre

JC,Jan 2026

FLN - GRU

Plane was late in FLN and missed connection in GRU. No alternative was given to me until 6 hours later and I was delayed by over 12 hours total.
LATAM Airlines
7.5
Good
1,900 reviews
LATAM Airlines
7.5
Good
1,900 reviews

Overall

7.5

Boarding

7.6

Comfort

7.3

Crew

8.0

Food

6.7

Entertainment

7.0

Reviews

1 / 20
2.0
Mediocre

JC,Jan 2026

FLN - GRU

Plane was late in FLN and missed connection in GRU. No alternative was given to me until 6 hours later and I was delayed by over 12 hours total.

Related info for your journey

Find useful and relevant information for your journey from Des Moines to Santiago. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • How long is the flight from Des Moines to Santiago?

    There are many flights that can get you from Des Moines to Santiago in 17h 40m. Fly via American Airlines or Delta to get the fastest option. Des Moines and Santiago are separated by a distance of 5374 mi. Both multi-stop and nonstop flights can be found to your destination and back.

  • What is the cheapest airline to fly from Des Moines to Santiago round-trip?

    Currently priced at $814, LATAM Airlines will fly you from Des Moines to Santiago and back. In addition to LATAM Airlines, many other airlines offer competitively priced options for your trip. LATAM Airlines is 28% cheaper than the average price of flights available within the next 90 days to this destination.

  • Can I find deals for flights from Des Moines to Santiago that include hotel bookings?

    Yes. In addition to deals on Des Moines to Santiago flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Des Moines to Santiago?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Des Moines to Santiago.

  • Can I find deals for business class flights from Des Moines to Santiago?

    Yes. Cheapflights offers flight deals from Des Moines to Santiago by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

See more FAQs

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Alternative routes for Des Moines to Santiago

See prices for flight routes from nearby airports that may be better suited for you.
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Top airline flying from Des Moines to Santiago

Discover the top airline that operate flights from Des Moines to Santiago. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated January 5, 2026.
AirlineCheapestAverageFlexibilityOn-time
LATAM AirlinesCheapest$814Average$1,203FlexibilityNo cancel feeOn-time81%

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