$328+ Cheap flights from Columbia, MO to Santa Ana, CA (COU - SNA)
This is the cheapest round-trip flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 10/31. Fares are subject to change and may not be available on all flights or dates of travel.
COU — SNA
Oct 9 — Oct 161
Round-trip
1 adult, Economy
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Find cheap flights from Columbia to Santa Ana with Cheapflights
1. Tell us where you want to go
Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”2. Select your favorite providers
We find the providers serving your travel needs. Choose up to four travel providers to compare side-by-side for flights, hotels, or car rentals.3. Compare prices and book
Review each provider’s pricing and select the best option for you! Book through your favorite provider’s website for a seamless experience.Cheap flight deals from Columbia to Santa Ana
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Best
Last-minute
Cheapest flights from Columbia to Santa AnaExplore the most affordable flight options available from Columbia to Santa Ana. Find the lowest fares from popular airlines and budget airlines, with prices last updated on September 9, 2026.
Explore the most affordable flight options available from Columbia to Santa Ana. Find the lowest fares from popular airlines and budget airlines, with prices last updated on September 9, 2026.
This American Airlines deal was found by Cheapflights users on 9/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/3112:01 pm -
1 stop7h 41m
Wed 11/48:49 am -
1 stop7h 03m
Deal found 9/4![American Airlines logo]()
$328
This American Airlines deal was found by Cheapflights users on 9/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/305:44 am -
1 stop6h 52m
Sat 10/310:35 am -
1 stop6h 48m
Deal found 9/5![American Airlines logo]()
$398
This American Airlines deal was found by Cheapflights users on 9/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/3112:01 pm -
1 stop7h 41m
Sat 11/711:40 am -
1 stop8h 35m
Deal found 9/4![American Airlines logo]()
$418
This United Airlines deal was found by Cheapflights users on 9/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 9/199:00 am -
1 stop6h 05m
Tue 9/227:15 am -
2 stops11h 24m
Deal found 9/5![United Airlines logo]()
$424
This United Airlines deal was found by Cheapflights users on 9/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/318:00 am -
2 stops12h 44m
Wed 11/411:10 am -
2 stops9h 48m
Deal found 9/8![United Airlines logo]()
$429
This United Airlines deal was found by Cheapflights users on 9/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 11/149:01 am -
1 stop7h 58m
Tue 11/172:22 pm -
1 stop6h 36m
Deal found 9/6![United Airlines logo]()
$438
This United Airlines deal was found by Cheapflights users on 9/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/303:19 pm -
1 stop9h 07m
Sat 10/37:30 am -
2 stops11h 03m
Deal found 9/9![United Airlines logo]()
$459
This United Airlines deal was found by Cheapflights users on 9/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 10/133:43 pm -
1 stop8h 43m
Fri 10/232:26 pm -
1 stop6h 29m
Deal found 9/8![United Airlines logo]()
$473
Best flights from Columbia to Santa AnaDiscover carefully curated flight deals from Columbia to Santa Ana that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated September 9, 2026.
Discover carefully curated flight deals from Columbia to Santa Ana that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated September 9, 2026.
This United Airlines deal was found by Cheapflights users on 9/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 11/149:01 am -
1 stop7h 58m
Tue 11/172:22 pm -
1 stop6h 36m
Deal found 9/8![United Airlines logo]()
$418
This United Airlines deal was found by Cheapflights users on 9/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/318:00 am -
2 stops11h 33m
Wed 11/411:10 am -
1 stop7h 31m
Deal found 9/8![United Airlines logo]()
$424
This United Airlines deal was found by Cheapflights users on 9/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/319:01 am -
1 stop6h 13m
Sat 11/77:20 am -
2 stops13h 38m
Deal found 9/4![United Airlines logo]()
$444
This United Airlines deal was found by Cheapflights users on 9/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/3011:15 am -
1 stop9h 26m
Sat 10/39:00 am -
2 stops11h 55m
Deal found 9/6![United Airlines logo]()
$444
Last-minute flights from Columbia to Santa AnaDiscover last-minute flight deals from Columbia to Santa Ana. Data last updated September 9, 2026 and is based on user searches.
Discover last-minute flight deals from Columbia to Santa Ana. Data last updated September 9, 2026 and is based on user searches.
This United Airlines deal was found by Cheapflights users on 9/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 9/199:00 am -
1 stop6h 05m
Tue 9/227:15 am -
2 stops11h 24m
Deal found 9/5![United Airlines logo]()
$424
This American Airlines deal was found by Cheapflights users on 9/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/305:44 am -
1 stop6h 52m
Sat 10/310:35 am -
1 stop6h 48m
Deal found 9/5![American Airlines logo]()
$398
This United Airlines deal was found by Cheapflights users on 9/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/303:19 pm -
1 stop9h 07m
Sat 10/37:30 am -
2 stops11h 03m
Deal found 9/9![United Airlines logo]()
$459
This United Airlines deal was found by Cheapflights users on 9/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 10/133:43 pm -
1 stop8h 43m
Wed 10/212:26 pm -
1 stop6h 29m
Deal found 9/8![United Airlines logo]()
$438
This United Airlines deal was found by Cheapflights users on 9/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 10/133:43 pm -
1 stop8h 43m
Fri 10/232:26 pm -
1 stop6h 29m
Deal found 9/8![United Airlines logo]()
$473
This American Airlines deal was found by Cheapflights users on 9/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/3112:01 pm -
1 stop7h 41m
Wed 11/48:49 am -
1 stop7h 03m
Deal found 9/5![American Airlines logo]()
$328
This American Airlines deal was found by Cheapflights users on 9/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/3112:01 pm -
1 stop7h 41m
Sat 11/711:40 am -
1 stop8h 35m
Deal found 9/4![American Airlines logo]()
$418
This United Airlines deal was found by Cheapflights users on 9/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/318:00 am -
2 stops12h 44m
Wed 11/411:10 am -
2 stops9h 48m
Deal found 9/8![United Airlines logo]()
$429
Find flight deals from Columbia to Santa Ana
Discover tips and strategies to find the most affordable flight options for your journey from Columbia (COU) to Santa Ana (SNA). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated September 9, 2026.
Most accurate provider | FlightHub 3 stars |
|---|---|
Most trusted provider | FlightHub 3 stars |
Round-trip from | $328 (American Airlines) |
Popular in | December |
Cheapest in | September |
Average price | $328 |
Cheapflights Fare Finder
Customize your flight search to find flights from Columbia to Santa Ana that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 7,457,451 searches. Data last updated September 9, 2026.
Use the filters below to find and compare flights from Columbia to Santa Ana that are best for you.
Fly from
Fly to
Route
Depart
Return
Cheapest round-trip
Quickest round-trip
ColumbiaSanta Ana
COU Columbia Regional - SNA Santa Ana J. Wayne/Orange Cnty
COUSNA
Columbia Regional
Sat 11/14
9:01 am-2:59 pm
1 stop7h 58m
Santa Ana J. Wayne/Orange Cnty
Tue 11/17
2:22 pm-10:58 pm
1 stop6h 36m
$418
ColumbiaSanta Ana
COU Columbia Regional - SNA Santa Ana J. Wayne/Orange Cnty
COUSNA
Columbia Regional
Sat 10/31
8:00 am-5:33 pm
2 stops11h 33m
Santa Ana J. Wayne/Orange Cnty
Wed 11/4
11:10 am-8:41 pm
1 stop7h 31m
$424
ColumbiaSanta Ana
COU Columbia Regional - SNA Santa Ana J. Wayne/Orange Cnty
COUSNA
Columbia Regional
Sat 10/31
9:01 am-1:14 pm
1 stop6h 13m
Santa Ana J. Wayne/Orange Cnty
Sat 11/7
7:20 am-10:58 pm
2 stops13h 38m
$444
ColumbiaSanta Ana
COU Columbia Regional - SNA Santa Ana J. Wayne/Orange Cnty
COUSNA
Columbia Regional
Wed 9/30
11:15 am-6:41 pm
1 stop9h 26m
Santa Ana J. Wayne/Orange Cnty
Sat 10/3
9:00 am-10:55 pm
2 stops11h 55m
$444
Sorted by cheapest first
Compare providers for flights from Columbia to Santa Ana
Provider information is updated monthly. Please note that these providers often have deals for this flight, but the availability may vary on a day-by-day basis on Cheapflights.
Use the table below to compare price accuracy, trust ratings, and cancellation policies for each provider offering flight deals from Columbia to Santa Ana in September.
| Provider | Price Accuracy | Trust Score* |
|---|---|---|
| Price Accuracy3 stars | Trust Score*3 stars | |
| Price Accuracy1 star | Trust Score*3 stars |
- Most accurate provider: When it comes to deals on Columbia, Missouri-Santa Ana, California flights, users find the pricing of FlightHub to be most consistent on Cheapflights vs. FlightHub Users can find the same prices on Columbia, Missouri-Santa Ana, California flight deals on Cheapflights vs. FlightHub >95% of the time. Price accuracy is based on data collected from Columbia, Missouri-Santa Ana, California flight searches over the past month and is updated monthly.
- Most trusted provider: When it comes to deals on Columbia, Missouri-Santa Ana, California flights, Cheapflights users trust FlightHub the most. FlightHub has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for Columbia, Missouri-Santa Ana, California flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.
Best time to book a flight from Columbia to Santa Ana
Have a flexible travel schedule? Discover the best time to fly to Santa Ana from Columbia with our price prediction graph.
COU-SNA
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.
Cheapflights Insights
Everything you need to know about your flight from Columbia to Santa Ana
Prices
More
What’s the top layover airport for flights from Columbia, Missouri to Santa Ana, California?
Share of 1-stop round-trip flights from Columbia, Missouri to Santa Ana, California chosen by Cheapflights users in the past 12 months, using the same layover each way.
Chicago (ORD) – chosen by Cheapflights users on 50% of 1-stop itineraries from Columbia, Missouri to Santa Ana, California on Cheapflights.
What’s the cheapest layover airport for flights from Columbia, Missouri to Santa Ana, California?
Average round-trip fare for 1-stop flights from Columbia, Missouri to Santa Ana, California, chosen by Cheapflights users in the past 12 months, with the same layover each way.
Denver (DEN) is the most affordable 1-stop option, with an average round-trip price of $408.
What’s the fastest layover option from Columbia, Missouri to Santa Ana, California?
Shortest average travel time for 1-stop one-way flights from Columbia, Missouri to Santa Ana, California, based on itineraries clicked by Cheapflights users over the past 12 months, grouped by layover airport.
Flights via Denver (DEN) have the shortest average one-way travel time for 1-stop routes: 8h 20m.
Which airport typically offers the quickest layover for flights from Columbia, Missouri to Santa Ana, California?
Average layover duration for 1-stop one-way flights from Columbia, Missouri to Santa Ana, California, chosen by Cheapflights users in the last 12 months, grouped by stopover airport.
Flights via Chicago (ORD) offer the fastest connection on this route, with an average layover time of 2h 10m.
Reviews of airlines servicing Santa Ana
Get insights into the airlines that provide service to Santa Ana. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Santa Ana. Reviews last updated September 9, 2026.
See what other customers who have flown with United Airlines and American Airlines from Columbia to Santa Ana have to say. You can also see how each airline compares in terms of entertainment options, comfort, food, crew/service, and boarding process.
Crew
8.1
Boarding
7.7
Food
6.6
Comfort
7.3
Overall
7.4
Entertainment
7.1
Reviews
1 / 20
4.0
OkaySimon,Jun 2024
LAS - LAX
Crew
8.1
Boarding
7.7
Food
6.6
Comfort
7.3
Overall
7.4
Entertainment
7.1
Reviews
1 / 20
4.0
OkaySimon,Jun 2024
LAS - LAX
Crew
8.1
Boarding
7.7
Food
6.6
Comfort
7.3
Overall
7.4
Entertainment
7.1
Reviews
1 / 20
4.0
OkaySimon,Jun 2024
LAS - LAX
Related info for your journey
Find useful and relevant information for your journey from Columbia to Santa Ana. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.
Traveling to a place near Santa Ana?
Book flights to Santa Ana if you plan to visit one of these locationsTustin
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Columbia and Santa Ana flights
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Top 2 airlines flying from Columbia to Santa Ana
Discover the top 2 airlines that operate flights from Columbia to Santa Ana. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 7,457,451 searches. Data last updated September 9, 2026.
| Airline | Cheapest | Average | Flexibility | On-time |
|---|---|---|---|---|
| Cheapest$328 | Average$464 | FlexibilityNo cancel fee | On-time69% | |
| Cheapest$328 | Average$488 | FlexibilityNo cancel fee | On-time71% |