$344+ Cheap flights from Panama City (PTY) to San Francisco (SFO)
This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 6/1. Fares are subject to change and may not be available on all flights or dates of travel.
PTY — SFO
Jun 6 — Jun 131
Round-trip
1 adult, Economy
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Find cheap flights from Panama City to San Francisco with Cheapflights
1. Tell us where you want to go
Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”2. Select your favorite providers
We find the providers serving your travel needs. Choose up to four travel providers to compare side-by-side for flights, hotels, or car rentals.3. Compare prices and book
Review each provider’s pricing and select the best option for you! Book through your favorite provider’s website for a seamless experience.Cheapflights Tip: The best prices from Panama City Tocumen Intl to San Francisco are usually found in August or September, booked 67 days in advance, depart on a Saturday or Friday and return on a Monday
Cheap flight deals from Panama City to San Francisco
Cheapest
Best
Last-minute
One-way
Cheapest flights from Panama City to San FranciscoExplore the most affordable flight options available from Panama City to San Francisco. Find the lowest fares from popular airlines and budget airlines, with prices last updated on May 7, 2026.
Explore the most affordable flight options available from Panama City to San Francisco. Find the lowest fares from popular airlines and budget airlines, with prices last updated on May 7, 2026.
This American Airlines deal was found by Cheapflights users on 5/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 9/113:40 pm
PTY
- SFO
2 stops23h 29m
American Airlines
Fri 9/2511:58 pm
SFO
- PTY
1 stop12h 12m
American Airlines
Deal found 5/5![American Airlines logo]()
$665
This American Airlines deal was found by Cheapflights users on 5/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 10/123:35 pm
PTY
- SFO
1 stop29h 06m
American Airlines
Sat 10/2412:12 pm
SFO
- PTY
1 stop23h 48m
American Airlines
Deal found 5/5![American Airlines logo]()
$677
This Avianca deal was found by Cheapflights users on 5/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Avianca is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 9/115:30 am
PTY
- SFO
1 stop9h 20m
Avianca
Fri 9/252:15 pm
SFO
- PTY
1 stop9h 40m
Avianca
Deal found 5/6![Avianca logo]()
$693
This BusinessClass deal was found by Cheapflights users on 5/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure BusinessClass is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 8/111:24 pm
PTY
- SFO
1 stop11h 27m
GOL
Sat 8/299:35 pm
SFO
- PTY
1 stop12h 49m
GOL
Deal found 5/3![GOL logo]()
$695
This American Airlines deal was found by Cheapflights users on 5/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 7/251:14 pm
PTY
- SFO
2 stops21h 51m
American Airlines
Wed 7/296:54 pm
SFO
- PTY
2 stops15h 20m
American Airlines
Deal found 5/3![American Airlines logo]()
$697
This BusinessClass deal was found by Cheapflights users on 5/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure BusinessClass is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 9/253:40 pm
PTY
- SFO
2 stops19h 41m
GOL
Sun 10/2511:59 pm
SFO
- PTY
1 stop12h 01m
GOL
Deal found 5/3![GOL logo]()
$699
This Kiwi.com deal was found by Cheapflights users on 5/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 7/95:30 am
PTY
- SFO
1 stop9h 20m
Multiple Airlines
Wed 7/1512:33 pm
SFO
- PTY
2 stops28h 47m
Multiple Airlines
Deal found 5/3![Multiple Airlines logo]()
$700
This Avianca deal was found by Cheapflights users on 5/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Avianca is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 9/255:30 am
PTY
- SFO
1 stop9h 20m
Avianca
Sat 10/242:35 am
SFO
- PTY
1 stop14h 20m
Avianca
Deal found 5/3![Avianca logo]()
$703
This Avianca deal was found by Cheapflights users on 5/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Avianca is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 7/1210:10 am
PTY
- SFO
2 stops14h 25m
Avianca
Sat 7/257:45 am
SFO
- PTY
2 stops16h 10m
Avianca
Deal found 5/6![Avianca logo]()
$704
Best flights from Panama City to San FranciscoDiscover carefully curated flight deals from Panama City to San Francisco that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated May 7, 2026.
Discover carefully curated flight deals from Panama City to San Francisco that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated May 7, 2026.
This Delta deal was found by Cheapflights users on 5/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 9/242:21 pm
PTY
- SFO
1 stop11h 41m
Delta
Sun 10/259:30 pm
SFO
- PTY
1 stop13h 26m
Delta
Deal found 5/3![Delta logo]()
$716
This United Airlines deal was found by Cheapflights users on 5/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 7/283:30 pm
PTY
- SFO
1 stop19h 55m
United Airlines
Thu 7/3011:59 pm
SFO
- PTY
1 stop12h 15m
United Airlines
Deal found 5/3![United Airlines logo]()
$716
This Copa Airlines deal was found by Cheapflights users on 5/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Copa Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 9/226:08 pm
PTY
- SFO
Nonstop7h 32m
Copa Airlines
Thu 9/241:12 am
SFO
- PTY
Nonstop7h 15m
Copa Airlines
Deal found 5/2![Copa Airlines logo]()
$726
This Delta deal was found by Cheapflights users on 5/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 9/242:21 pm
PTY
- SFO
1 stop11h 41m
Delta
Fri 10/233:30 pm
SFO
- PTY
1 stop19h 26m
Delta
Deal found 5/3![Delta logo]()
$716
This Copa Airlines deal was found by Cheapflights users on 5/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Copa Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 9/116:08 pm
PTY
- SFO
Nonstop7h 32m
Copa Airlines
Thu 9/241:12 am
SFO
- PTY
Nonstop7h 15m
Copa Airlines
Deal found 5/4![Copa Airlines logo]()
$726
This United Airlines deal was found by Cheapflights users on 5/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 6/210:00 am
PTY
- SFO
1 stop10h 30m
United Airlines
Thu 7/26:54 pm
SFO
- PTY
1 stop21h 43m
United Airlines
Deal found 5/5![United Airlines logo]()
$734
This Delta deal was found by Cheapflights users on 5/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 7/122:24 pm
PTY
- SFO
1 stop12h 12m
Delta
Sat 7/254:10 pm
SFO
- PTY
1 stop18h 55m
Delta
Deal found 5/4![Delta logo]()
$716
This United Airlines deal was found by Cheapflights users on 5/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 6/210:00 am
PTY
- SFO
1 stop10h 30m
United Airlines
Fri 7/36:54 pm
SFO
- PTY
1 stop19h 18m
United Airlines
Deal found 5/5![United Airlines logo]()
$734
This Delta deal was found by Cheapflights users on 5/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 9/282:21 pm
PTY
- SFO
1 stop11h 41m
Delta
Sun 10/2511:45 pm
SFO
- PTY
1 stop11h 11m
Delta
Deal found 5/3![Delta logo]()
$716
This United Airlines deal was found by Cheapflights users on 5/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 8/283:30 pm
PTY
- SFO
1 stop20h 00m
United Airlines
Mon 8/316:54 pm
SFO
- PTY
1 stop17h 20m
United Airlines
Deal found 5/6![United Airlines logo]()
$735
Last-minute flights from Panama City to San FranciscoDiscover last-minute flight deals from Panama City to San Francisco. Data last updated May 7, 2026 and is based on user searches.
Discover last-minute flight deals from Panama City to San Francisco. Data last updated May 7, 2026 and is based on user searches.
This Avianca deal was found by Cheapflights users on 5/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Avianca is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 5/1110:10 am
PTY
- SFO
2 stops14h 25m
Avianca
Sat 5/237:45 pm
SFO
- PTY
2 stops12h 45m
Avianca
Deal found 5/5![Avianca logo]()
$744
This Avianca deal was found by Cheapflights users on 5/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Avianca is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 5/1210:10 am
PTY
- SFO
2 stops14h 25m
Avianca
Tue 5/1911:55 pm
SFO
- PTY
1 stop8h 35m
Avianca
Deal found 5/5![Avianca logo]()
$715
This Avianca deal was found by Cheapflights users on 5/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Avianca is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 6/15:30 am
PTY
- SFO
1 stop9h 20m
Avianca
Mon 6/87:45 am
SFO
- PTY
2 stops16h 10m
Avianca
Deal found 5/4![Avianca logo]()
$704
This American Airlines deal was found by Cheapflights users on 5/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 6/11:14 pm
PTY
- SFO
2 stops24h 10m
American Airlines
Mon 6/811:59 pm
SFO
- PTY
1 stop10h 14m
American Airlines
Deal found 5/4![American Airlines logo]()
$732
This Copa Airlines deal was found by Cheapflights users on 5/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Copa Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 6/15:55 pm
PTY
- SFO
Nonstop7h 45m
Copa Airlines
Sun 6/71:12 am
SFO
- PTY
Nonstop7h 15m
Copa Airlines
Deal found 5/4![Copa Airlines logo]()
$745
This Kiwi.com deal was found by Cheapflights users on 5/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 6/17:55 am
PTY
- SFO
1 stop13h 41m
Multiple Airlines
Mon 6/83:21 pm
SFO
- PTY
1 stop17h 03m
Multiple Airlines
Deal found 5/4![Multiple Airlines logo]()
$747
This Kiwi.com deal was found by Cheapflights users on 5/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 6/27:55 am
PTY
- SFO
1 stop13h 41m
Multiple Airlines
Tue 6/163:26 pm
SFO
- PTY
1 stop16h 58m
Multiple Airlines
Deal found 5/2![Multiple Airlines logo]()
$738
This American Airlines deal was found by Cheapflights users on 5/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 6/31:14 pm
PTY
- SFO
2 stops22h 14m
American Airlines
Wed 6/102:03 pm
SFO
- PTY
2 stops20h 10m
American Airlines
Deal found 5/4![American Airlines logo]()
$713
This United Airlines deal was found by Cheapflights users on 5/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 6/310:00 am
PTY
- SFO
1 stop16h 05m
United Airlines
Fri 7/312:45 am
SFO
- PTY
1 stop15h 52m
United Airlines
Deal found 5/5![United Airlines logo]()
$734
This Avianca deal was found by Cheapflights users on 5/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Avianca is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 6/285:30 am
PTY
- SFO
1 stop9h 20m
Avianca
Thu 7/302:30 am
SFO
- PTY
1 stop21h 25m
Avianca
Deal found 5/5![Avianca logo]()
$721
This United Airlines deal was found by Cheapflights users on 5/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 6/287:55 am
PTY
- SFO
1 stop25h 27m
United Airlines
Thu 7/3012:45 am
SFO
- PTY
1 stop13h 27m
United Airlines
Deal found 5/5![United Airlines logo]()
$726
This United Airlines deal was found by Cheapflights users on 5/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 6/303:30 pm
PTY
- SFO
1 stop10h 35m
United Airlines
Thu 7/911:59 pm
SFO
- PTY
1 stop12h 15m
United Airlines
Deal found 5/3![United Airlines logo]()
$716
One-way flights from Panama City to San FranciscoSearch for one-way flight options from Panama City to San Francisco. Find affordable one-way fares based on user searches. Data last updated May 7, 2026.
Search for one-way flight options from Panama City to San Francisco. Find affordable one-way fares based on user searches. Data last updated May 7, 2026.
This Trip.com deal was found by Cheapflights users on 5/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Trip.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 6/19:33 pm
PTY
- SFO
2 stops16h 14m
Multiple Airlines
Deal found 5/2![Multiple Airlines logo]()
$344
This Kiwi.com deal was found by Cheapflights users on 5/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 6/245:30 am
PTY
- SFO
3 stops32h 13m
Multiple Airlines
Deal found 5/3![Multiple Airlines logo]()
$360
This Kiwi.com deal was found by Cheapflights users on 5/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 6/75:55 pm
PTY
- SFO
2 stops31h 09m
Multiple Airlines
Deal found 5/3![Multiple Airlines logo]()
$365
This Cheapflightsfares deal was found by Cheapflights users on 5/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Cheapflightsfares is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 6/43:50 pm
PTY
- SFO
1 stop10h 05m
Avianca
Deal found 5/5![Avianca logo]()
$368
This Kiwi.com deal was found by Cheapflights users on 5/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 5/313:10 pm
PTY
- SFO
3 stops22h 37m
Multiple Airlines
Deal found 5/5![Multiple Airlines logo]()
$370
This Avianca deal was found by Cheapflights users on 5/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Avianca is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 7/210:10 am
PTY
- SFO
2 stops15h 45m
Avianca
Deal found 5/6![Avianca logo]()
$377
This Kiwi.com deal was found by Cheapflights users on 5/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 6/114:25 am
PTY
- SFO
3 stops46h 02m
Multiple Airlines
Deal found 5/4![Multiple Airlines logo]()
$386
This Avianca deal was found by Cheapflights users on 5/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Avianca is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 5/1410:10 am
PTY
- SFO
2 stops15h 45m
Avianca
Deal found 5/5![Avianca logo]()
$388
This Avianca deal was found by Cheapflights users on 5/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Avianca is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 5/315:30 am
PTY
- SFO
1 stop9h 20m
Avianca
Deal found 5/5![Avianca logo]()
$389
Find flight deals from Panama City to San Francisco
Discover tips and strategies to find the most affordable flight options for your journey from Panama City (PTY) to San Francisco (SFO). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated May 7, 2026.
Most accurate provider | FlightHub 3 stars |
|---|---|
Most trusted provider | FlightHub 3 stars |
Round-trip from | $665 (American Airlines) |
One-way from | $344 (Trip.com) |
Popular in | February |
Cheapest in | August |
Average price | $669 |
Good round-trip deal | $483 or less |
Good one-way deal | $1,810 or less |
Cheapflights Fare Finder
Customize your flight search to find flights from Panama City to San Francisco that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated May 7, 2026.
Use the filters below to find and compare flights from Panama City to San Francisco that are best for you.
Fly from
Fly to
Route
Depart
Return
Cheapest round-trip
Panama CitySan Francisco
PTY - SFO
PTYSFO
Panama City Tocumen Intl
Thu 9/24
2:21 pm-12:02 am
1 stop11h 41m
San Francisco
Sun 10/25
9:30 pm-12:56 pm
1 stop13h 26m
$716
Panama CitySan Francisco
PTY - SFO
PTYSFO
Panama City Tocumen Intl
Tue 7/28
3:30 pm-9:25 am
1 stop19h 55m
San Francisco
Thu 7/30
11:59 pm-2:14 pm
1 stop12h 15m
$716
Panama CitySan Francisco
PTY - SFO
PTYSFO
Panama City Tocumen Intl
Thu 9/24
2:21 pm-12:02 am
1 stop11h 41m
San Francisco
Fri 10/23
3:30 pm-12:56 pm
1 stop19h 26m
$716
Panama CitySan Francisco
PTY - SFO
PTYSFO
Panama City Tocumen Intl
Sun 7/12
2:24 pm-12:36 am
1 stop12h 12m
San Francisco
Sat 7/25
4:10 pm-1:05 pm
1 stop18h 55m
$716
Panama CitySan Francisco
PTY - SFO
PTYSFO
Panama City Tocumen Intl
Mon 9/28
2:21 pm-12:02 am
1 stop11h 41m
San Francisco
Sun 10/25
11:45 pm-12:56 pm
1 stop11h 11m
$716
Quickest round-trip
Panama CitySan Francisco
PTY - SFO
PTYSFO
Panama City Tocumen Intl
Tue 9/22
6:08 pm-11:40 pm
Nonstop7h 32m
San Francisco
Thu 9/24
1:12 am-10:27 am
Nonstop7h 15m
$726
Panama CitySan Francisco
PTY - SFO
PTYSFO
Panama City Tocumen Intl
Fri 9/11
6:08 pm-11:40 pm
Nonstop7h 32m
San Francisco
Thu 9/24
1:12 am-10:27 am
Nonstop7h 15m
$726
Panama CitySan Francisco
PTY - SFO
PTYSFO
Panama City Tocumen Intl
Tue 6/2
10:00 am-6:30 pm
1 stop10h 30m
San Francisco
Thu 7/2
6:54 pm-6:37 pm
1 stop21h 43m
$734
Panama CitySan Francisco
PTY - SFO
PTYSFO
Panama City Tocumen Intl
Tue 6/2
10:00 am-6:30 pm
1 stop10h 30m
San Francisco
Fri 7/3
6:54 pm-4:12 pm
1 stop19h 18m
$734
Panama CitySan Francisco
PTY - SFO
PTYSFO
Panama City Tocumen Intl
Fri 8/28
3:30 pm-9:30 am
1 stop20h 00m
San Francisco
Mon 8/31
6:54 pm-2:14 pm
1 stop17h 20m
$735
Showing 1-10 of 19 resultsSorted by cheapest first
Compare providers for flights from Panama City to San Francisco
Provider information is updated monthly. Please note that these providers often have deals for this flight, but the availability may vary on a day-by-day basis on Cheapflights.
Use the table below to compare price accuracy, trust ratings, and cancellation policies for each provider offering flight deals from Panama City to San Francisco in May.
| Provider | Price Accuracy | Trust Score* |
|---|---|---|
| Price Accuracy1 star | Trust Score*3 stars | |
| Price Accuracy3 stars | Trust Score*3 stars | |
| Price Accuracy3 stars | Trust Score*3 stars |
- Most accurate provider: When it comes to deals on Panama City-San Francisco flights, users find the pricing of FlightHub to be most consistent on Cheapflights vs. FlightHub Users can find the same prices on Panama City-San Francisco flight deals on Cheapflights vs. FlightHub >95% of the time. Price accuracy is based on data collected from Panama City-San Francisco flight searches over the past month and is updated monthly.
- Most trusted provider: When it comes to deals on Panama City-San Francisco flights, Cheapflights users trust FlightHub the most. FlightHub has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for Panama City-San Francisco flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.
Best time to book a flight from Panama City to San Francisco
Have a flexible travel schedule? Discover the best time to fly to San Francisco from Panama City with our price prediction graph.
PTY-SFO
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.
Cheapflights Insights
Everything you need to know about your flight from Panama City to San Francisco
Prices
Airlines
How far ahead should I book a flight from Panama City to San Francisco?
The price you pay for your flight from Panama City to San Francisco may vary depending on when you book. For the best chance of a lower fare, look to book 63 days in advance of your trip. Fares are likely to increase a fortnight or so before your departure date.
What is the cheapest month to book a flight from Panama City to San Francisco?
Currently, August is the cheapest month in which you can book a flight from Panama City to San Francisco (average of $562). Flying from Panama City to San Francisco in February is currently the most expensive (average of $793). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.
What is the cheapest time of day to fly from PTY to SFO?
Find hourly flight availability from Panama City to San Francisco. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated May 7, 2026.
When flying from Panama City to San Francisco, the time of day you decide to fly out makes little to no difference towards the overall price you’ll pay on tickets.
The best insider tips for Panama City to San Francisco flights
AI-powered summary based on content written by travel experts. AI can make mistakes.
Cheapflights partnered with top experts to bring you the best recommendations for your Panama City to San Francisco trip
Our travel experts
Reviews of airlines servicing San Francisco
Get insights into the airlines that provide service to San Francisco. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to San Francisco. Reviews last updated May 7, 2026.
Read through reviews of airlines operating flights from Panama City to San Francisco, such as Copa Airlines,United Airlines, andAvianca. You can also see how each airline stacks up in terms of entertainment options, comfort, food, crew/service, and boarding process.
Overall
7.5
Comfort
7.4
Crew
8.1
Entertainment
6.8
Boarding
7.8
Food
6.8
Reviews
1 / 20
10.0
ExcellentAnonymous,Apr 2026
LIM - PTY
Overall
7.5
Comfort
7.4
Crew
8.1
Entertainment
6.8
Boarding
7.8
Food
6.8
Reviews
1 / 20
10.0
ExcellentAnonymous,Apr 2026
LIM - PTY
Overall
7.5
Comfort
7.4
Crew
8.1
Entertainment
6.8
Boarding
7.8
Food
6.8
Reviews
1 / 20
10.0
ExcellentAnonymous,Apr 2026
LIM - PTY
Overall
7.5
Comfort
7.4
Crew
8.1
Entertainment
6.8
Boarding
7.8
Food
6.8
Reviews
1 / 20
10.0
ExcellentAnonymous,Apr 2026
LIM - PTY
Related info for your journey
Find useful and relevant information for your journey from Panama City to San Francisco. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.
Traveling to a place near San Francisco?
Book flights to San Francisco if you plan to visit one of these locationsSouth San Francisco
Santa Cruz
Santa Clara
Fairfield
Rancho Cordova
San Bruno
Watsonville
San Ramon
Emeryville
Vacaville
Roseville
San Carlos
Redwood City
Sunnyvale
Turlock
San Lorenzo
Davis
Manteca
Union City
Elk Grove
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Panama City and San Francisco flights
Browse other Panama City and San Francisco flight options. Last updated on May 7, 2026.
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Top 3 airlines flying from Panama City to San Francisco
Discover the top 3 airlines that operate flights from Panama City to San Francisco. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated May 7, 2026.
| Airline | Cheapest | Average | Flexibility | On-time |
|---|---|---|---|---|
| Cheapest$281 | Average$535 | FlexibilityNo cancel fee | On-time71% | |
| Cheapest$359 | Average$680 | FlexibilityNo cancel fee | On-time70% | |
| Cheapest$506 | Average$684 | FlexibilityNo cancel fee | On-time69% |