HomeSearch by dateVacation packagesHotelsFlight dealsCar rentalTravel tips & news
San Francisco

$276+ Cheap flights from Panama City (PTY) to San Francisco (SFO)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 10/21. Fares are subject to change and may not be available on all flights or dates of travel.
PTY — SFO
Aug 22 — Aug 291
Fri 8/22
Fri 8/29
1 adult, Economy
We work with more than 300 partners to bring you better travel deals

Find cheap flights from Panama City to San Francisco with Cheapflights

1. Tell us where you want to go

Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”

2. Select your favorite providers

We find the providers serving your travel needs. Choose up to four travel providers to compare side-by-side for flights, hotels, or car rentals.

3. Compare prices and book

Review each provider’s pricing and select the best option for you! Book through your favorite provider’s website for a seamless experience.

Cheapflights Tip: The best prices from Panama City Tocumen Intl to San Francisco are usually found in August or June, booked 67 days in advance, depart on a Monday or Thursday and return on a Tuesday

Cheap flight deals from Panama City to San Francisco

Discover tips and strategies to find the most affordable flight options for your journey from Panama City (PTY) to San Francisco (SFO). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated August 17, 2025.

Round-trip from

$493
(Cheapflightsfares)

One-way from

$276
(Gotogate)

Popular in

March

Cheapest in

August

Average price

$537

Good round-trip deal

$585 or less

Good one-way deal

$390 or less
From Panama City Tocumen Intl to San Francisco
Search Deals
One-way flight from Panama City Tocumen Intl to San Francisco
Search Deals
Highest demand for flights based on searches. 3% potential increase in price ($20 potential increase over avg. RT price).
Search Deals
Cheapest flight prices on average. 0% potential price decrease ($5 potential savings vs. average RT price).
Search Deals
Average for round-trip flights in August 2025
Search Deals
Price to beat on a round-trip flight from Panama City Tocumen Intl to San Francisco.
Search Deals
Price to beat on a one-way flight from Panama City Tocumen Intl to San Francisco.
Search Deals

Find flight deals from Panama City to San Francisco

Cheapest flights from Panama City to San Francisco
Explore the most affordable flight options available from Panama City to San Francisco. Find the lowest fares from popular airlines and budget airlines, with prices last updated on August 17, 2025.

This Cheapflightsfares deal was found by Cheapflights users on 8/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Cheapflightsfares is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 9/110:05 pmPTY - SFO
2 stops16h 30mAvianca
Mon 9/82:20 pmSFO - PTY
2 stops16h 35mAvianca
Deal found 8/17$493
This Mytrip deal was found by Cheapflights users on 8/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 8/2910:05 pmPTY - SFO
2 stops27h 50mAvianca
Sat 11/11:35 amSFO - PTY
2 stops21h 25mAvianca
Deal found 8/15$496
This Avianca deal was found by Cheapflights users on 8/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Avianca is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 9/293:40 pmPTY - SFO
1 stop9h 05mAvianca
Mon 10/62:20 pmSFO - PTY
1 stop18h 05mAvianca
Deal found 8/15$499
This Priceline deal was found by Cheapflights users on 8/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Priceline is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 9/49:55 amPTY - SFO
2 stops14h 50mAvianca
Sat 9/612:05 amSFO - PTY
2 stops14h 25mAvianca
Deal found 8/15$502
This Booking.com deal was found by Cheapflights users on 8/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Booking.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 11/149:45 amPTY - SFO
2 stops15h 05mAvianca
Sun 11/161:20 pmSFO - PTY
2 stops21h 40mAvianca
Deal found 8/16$506
This Cheapflightsfares deal was found by Cheapflights users on 8/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Cheapflightsfares is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 9/23:40 pmPTY - SFO
1 stop22h 55mAvianca
Mon 9/812:05 amSFO - PTY
1 stop8h 20mAvianca
Deal found 8/15$509
This Avianca deal was found by Cheapflights users on 8/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Avianca is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/1511:00 amPTY - SFO
2 stops13h 45mAvianca
Fri 10/172:20 pmSFO - PTY
1 stop18h 05mAvianca
Deal found 8/15$510
This Booking.com deal was found by Cheapflights users on 8/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Booking.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 8/183:25 amPTY - SFO
2 stops22h 30mAvianca
Mon 8/2512:05 amSFO - PTY
1 stop8h 20mAvianca
Deal found 8/15$512
This Cheapflightsfares deal was found by Cheapflights users on 8/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Cheapflightsfares is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/119:55 amPTY - SFO
2 stops14h 50mAvianca
Sat 10/182:20 pmSFO - PTY
1 stop18h 05mAvianca
Deal found 8/17$513

Cheapflights Fare Finder

 
Customize your flight search to find flights from Panama City to San Francisco that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated August 17, 2025.
Use the filters below to find and compare flights from Panama City to San Francisco that are best for you.

Fly from

Panama City

Fly to

San Francisco

Route

Depart

Return

Price

Panama CitySan Francisco

PTY - SFO

PTYSFO

Panama City Tocumen Intl

Tue 10/14

3:20 am-10:45 pm

2 stops21h 25m

San Francisco

Thu 10/16

2:30 am-9:10 pm

2 stops16h 40m

$493

Panama CitySan Francisco

PTY - SFO

PTYSFO

Panama City Tocumen Intl

Mon 9/1

10:05 pm-12:35 pm

2 stops16h 30m

San Francisco

Sun 9/7

12:05 am-4:30 pm

2 stops14h 25m

$493

Panama CitySan Francisco

PTY - SFO

PTYSFO

Panama City Tocumen Intl

Thu 9/4

3:40 pm-10:45 pm

1 stop9h 05m

San Francisco

Sun 9/7

2:20 pm-10:10 am

2 stops17h 50m

$493

Panama CitySan Francisco

PTY - SFO

PTYSFO

Panama City Tocumen Intl

Fri 8/29

3:40 pm-10:45 pm

1 stop9h 05m

San Francisco

Sat 11/1

1:35 am-2:50 pm

1 stop11h 15m

$493

Panama CitySan Francisco

PTY - SFO

PTYSFO

Panama City Tocumen Intl

Thu 9/4

3:40 pm-10:45 pm

1 stop9h 05m

San Francisco

Sun 9/7

12:05 am-4:30 pm

2 stops14h 25m

$493

Panama CitySan Francisco

PTY - SFO

PTYSFO

Panama City Tocumen Intl

Fri 10/10

3:25 am-10:45 pm

2 stops21h 20m

San Francisco

Tue 10/14

12:05 am-9:10 pm

2 stops19h 05m

$493

Panama CitySan Francisco

PTY - SFO

PTYSFO

Panama City Tocumen Intl

Thu 8/28

3:40 pm-11:55 pm

1 stop10h 15m

San Francisco

Sun 8/31

2:20 pm-10:10 am

2 stops17h 50m

$493

Panama CitySan Francisco

PTY - SFO

PTYSFO

Panama City Tocumen Intl

Fri 9/12

11:00 am-10:45 pm

2 stops13h 45m

San Francisco

Sun 9/21

12:05 am-4:15 pm

1 stop14h 10m

$493

Panama CitySan Francisco

PTY - SFO

PTYSFO

Panama City Tocumen Intl

Tue 10/21

9:55 am-10:45 pm

2 stops14h 50m

$276

Panama CitySan Francisco

PTY - SFO

PTYSFO

Panama City Tocumen Intl

Wed 10/22

10:05 pm-12:35 pm

2 stops16h 30m

$279

Flights are sorted by cheapest round-trip flights first.

Deals found on 8/17

Showing 1-10 of 16 results
1
2

The best insider tips for Panama City to San Francisco flights

Snippets provided in this section are AI-generated based on a summarization of Cheapflights-commissioned articles. The articles are presented as-is, for general informational purposes only, and may not be up-to-date. The opinions contained in the articles are original to the author and reflect their authentic experience, which may vary significantly from the experience of others.
Cheapflights partnered with top experts to bring you the best recommendations for your Panama City to San Francisco trip
Airports
PTY

For US-bound flights, expect two security checks at PTY, with the second at the gate. Allow extra time for this process.

Read more about PTYby Taryn White
SFO

Use BART for affordable travel from SFO to downtown San Francisco. The trip takes about 40 minutes and starts from the Garage G/Bart station.

Read more about SFOby Harriet Baskas
Our travel experts
Taryn White

Taryn White

Expert on PTY

Taryn White

Taryn White

Taryn White is a freelance travel writer, digital creator, and travel advisor who has visited nearly 100 countries and all 50 states. She’s familiar with many airports and enjoys beach hopping, boutique hotels, spa experiences, and exploring local culture. Her work has appeared in Travel + Leisure, Condé Nast Traveler, National Geographic, Smithsonian Magazine, AFAR, and more.

Read more
Harriet Baskas

Harriet Baskas

Expert on SFO

Harriet Baskas

Harriet Baskas

Harriet is an award-winning journalist who is happiest in an airport or an unusual museum. Her stories about airports, air travel, and the business of travel have appeared on NBC News, CNBC, USA TODAY, The Points Guy and other outlets. She is the creator of the StuckatTheAirport.com blog and the author of nine books. When not out on the road or exploring the latest airport amenities, she’s home in Seattle getting ready for the next adventure.

Read more

Best time to book a flight from Panama City to San Francisco

Have a flexible travel schedule? Discover the best time to fly to San Francisco from Panama City with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Panama City to San Francisco

How far ahead should I book a flight from Panama City to San Francisco?

Use this chart to determine the optimal time to book a round-trip flight from Panama City to San Francisco. Price data was last updated on August 8, 2025.

The price you pay for your flight from Panama City to San Francisco may vary depending on when you book. For the best chance of a lower fare, look to book 67 days in advance of your trip. Fares are likely to increase a fortnight or so before your departure date.

What is the cheapest month to book a flight from Panama City to San Francisco?

Currently, January is the cheapest month in which you can book a flight from Panama City to San Francisco (average of $276). Flying from Panama City to San Francisco in June is currently the most expensive (average of $358). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from PTY to SFO?

Find hourly flight availability from Panama City to San Francisco. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated August 17, 2025.

Unlike in the afternoon, when flights are generally more expensive, you can save up to 41% on flights from Panama City to San Francisco by exploring options for tickets in the evening.

Weekly flight availability from Panama City to San Francisco

Explore weekly flight availability from Panama City to San Francisco. Discover flights operating on different days of the week, giving you the flexibility to choose a travel day that best fits your plans. Compare info to find the most convenient option for your journey. Data last updated August 17, 2025.

The most flights from PTY to SFO are scheduled on a Monday (4 on average). You will have fewer flight options on Tuesday, which is when the least amount of flights are scheduled (2 on average).

Reviews of airlines servicing San Francisco

Get insights into the airlines that provide service to San Francisco. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to San Francisco. Reviews last updated August 17, 2025.
Read through reviews of airlines operating flights from Panama City to San Francisco, such as Copa Airlines, United Airlines, and Avianca. You can also see how each airline stacks up in terms of entertainment options, comfort, food, crew/service, and boarding process.
Copa Airlines
7.5
Good
1,510 reviews

Boarding

7.8

Entertainment

6.8

Crew

8.1

Overall

7.5

Food

6.8

Comfort

7.4

Reviews

1 / 20
4.0
Okay

Paul,Jun 2025

PTY - MIA

The boarding process was terrible. No one followed the group numbers. Everyone got up and stood in the tiles upon landing. People kept getting up during the meal and beverage service to go the bathrooms, the crew had to go back and forth in the isles, the service took forever.
Copa Airlines
7.5
Good
1,510 reviews
Copa Airlines
7.5
Good
1,510 reviews

Boarding

7.8

Entertainment

6.8

Crew

8.1

Overall

7.5

Food

6.8

Comfort

7.4

Reviews

1 / 20
4.0
Okay

Paul,Jun 2025

PTY - MIA

The boarding process was terrible. No one followed the group numbers. Everyone got up and stood in the tiles upon landing. People kept getting up during the meal and beverage service to go the bathrooms, the crew had to go back and forth in the isles, the service took forever.
United Airlines
7.4
Good
8,919 reviews
Copa Airlines
7.5
Good
1,510 reviews

Boarding

7.8

Entertainment

6.8

Crew

8.1

Overall

7.5

Food

6.8

Comfort

7.4

Reviews

1 / 20
4.0
Okay

Paul,Jun 2025

PTY - MIA

The boarding process was terrible. No one followed the group numbers. Everyone got up and stood in the tiles upon landing. People kept getting up during the meal and beverage service to go the bathrooms, the crew had to go back and forth in the isles, the service took forever.
Avianca
6.7
Okay
2,407 reviews
Copa Airlines
7.5
Good
1,510 reviews

Boarding

7.8

Entertainment

6.8

Crew

8.1

Overall

7.5

Food

6.8

Comfort

7.4

Reviews

1 / 20
4.0
Okay

Paul,Jun 2025

PTY - MIA

The boarding process was terrible. No one followed the group numbers. Everyone got up and stood in the tiles upon landing. People kept getting up during the meal and beverage service to go the bathrooms, the crew had to go back and forth in the isles, the service took forever.

Related info for your journey

Find useful and relevant information for your journey from Panama City to San Francisco. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airports do I use to fly from Panama City to San Francisco?

    If you book a flight from Panama City to San Francisco, you will be flying from Tocumen Intl to San Francisco. Flights to San Francisco (SFO) from Panama City Tocumen Intl (PTY) take 7h 35m for a nonstop flight. There are 3 flights from Tocumen Intl to San Francisco per day from 3 airlines.

  • How popular is this Panama City to San Francisco flight route?

    The Panama City Tocumen Intl to San Francisco flight path was viewed by 1 users in the past month. Keep an eye out for changes in search interest prior to high and low season.

  • What are the cheapest airlines flying from Panama City to San Francisco round-trip?

    Cheapflights users have booked flights from Panama City to San Francisco round-trip from $474. Other airlines that can offer you cheap pricing are United Airlines, from $506, and Copa Airlines, from $506. Avianca is priced at 25% lower than the current average price of a flight leaving 3 months from now.

  • What are the cheapest flights from Panama City to San Francisco?

    The cheapest flight price from Panama City to San Francisco is $319. On average you can expect to pay $633. The most popular route, (Panama City Tocumen Intl - San Francisco), can usually be booked for $507.

  • Can I find deals for flights from Panama City to San Francisco that include hotel bookings?

    Yes. In addition to deals on Panama City to San Francisco flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Panama City to San Francisco?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Panama City to San Francisco.

  • Can I find deals for business class flights from Panama City to San Francisco?

    Yes. Cheapflights offers flight deals from Panama City to San Francisco by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Panama City to San Francisco?

    Currently, January is the cheapest month in which you can book a flight from Panama City to San Francisco (average of $276). Flying from Panama City to San Francisco in June is currently the most expensive (average of $358). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Traveling to a place near San Francisco?

Book flights to San Francisco if you plan to visit one of these locations
Roseville
Santa Cruz
Livermore
South San Francisco
Mountain View
Turlock
Santa Clara
Hollister
Antioch
Watsonville
Manteca
Sunnyvale
Newark
Milpitas
Campbell
Foster City
San Leandro
Burlingame
Redwood City
Vallejo

Browse thousands of different options on Cheapflights for your next trip

Toggle through the tabs below to find thousands of options on Cheapflights for your next trip.

Top 3 airlines flying from Panama City to San Francisco

Discover the top 3 airlines that operate flights from Panama City to San Francisco. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated August 17, 2025.
AirlineCheapestAverageFlexibilityOn-time
AviancaCheapest$474Average$615FlexibilityNo cancel feeOn-time71%
United AirlinesCheapest$506Average$640FlexibilityNo cancel feeOn-time69%
Copa AirlinesCheapest$506Average$632FlexibilityNo cancel feeOn-time70%

100% Free

Cheapflights is completely free to use, so you can start saving the moment you arrive.

Book with Flexibility

Our users can plan ahead with confidence and find flights with no change fees

Travel Smart

Millions of people come to us for their flight needs every year. We help make travel planning easy by providing useful insights and data-driven graphs that can inform your decisions.
Site
©2025 Cheapflights