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$277+ Cheap flights from Panama City (PTY) to San Francisco (SFO)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 12/14. Fares are subject to change and may not be available on all flights or dates of travel.
PTY — SFO
Jan 7 — Jan 141
Wed 1/7
Wed 1/14
1 adult, Economy
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Cheapflights Tip: The best prices from Panama City Tocumen Intl to San Francisco are usually found in August or September, booked 67 days in advance, depart on a Monday or Sunday and return on a Tuesday

Cheap flight deals from Panama City to San Francisco

Cheapest flights from Panama City to San Francisco
Explore the most affordable flight options available from Panama City to San Francisco. Find the lowest fares from popular airlines and budget airlines, with prices last updated on December 8, 2025.

This Kiwi.com deal was found by Cheapflights users on 12/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 12/267:50 pmPTY - SFO
1 stop19h 10mMultiple Airlines
Mon 1/59:30 pmSFO - PTY
2 stops34h 00mMultiple Airlines
Deal found 12/6$626
This Avianca deal was found by Cheapflights users on 12/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Avianca is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 12/267:50 pmPTY - SFO
1 stop19h 10mAvianca
Mon 1/511:10 pmSFO - PTY
1 stop8h 20mAvianca
Deal found 12/6$633
This Cheapflightsfares deal was found by Cheapflights users on 12/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Cheapflightsfares is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 12/293:50 pmPTY - SFO
1 stop23h 10mAvianca
Fri 1/211:10 pmSFO - PTY
1 stop8h 20mAvianca
Deal found 12/6$696
This Expedia deal was found by Cheapflights users on 12/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Expedia is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 12/87:50 pmPTY - SFO
1 stop19h 10mMultiple Airlines
Tue 12/2311:07 pmSFO - PTY
2 stops38h 48mMultiple Airlines
Deal found 12/5$724
This Kiwi.com deal was found by Cheapflights users on 12/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 12/233:50 pmPTY - SFO
1 stop10h 30mMultiple Airlines
Sat 12/279:30 pmSFO - PTY
2 stops52h 54mMultiple Airlines
Deal found 12/7$729
This Cheapflightsfares deal was found by Cheapflights users on 12/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Cheapflightsfares is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 12/89:45 amPTY - SFO
2 stops15h 05mAvianca
Mon 12/151:20 pmSFO - PTY
1 stop18h 10mAvianca
Deal found 12/7$795

Find flight deals from Panama City to San Francisco

Discover tips and strategies to find the most affordable flight options for your journey from Panama City (PTY) to San Francisco (SFO). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated December 8, 2025.

Most accurate provider

eDreams
3 stars

Most trusted provider

eDreams
3 stars

Round-trip from

$491
(Flysmarter)

One-way from

$277
(Cheapflightsfares)

Popular in

March

Cheapest in

August

Average price

$693

Good round-trip deal

$519 or less

Good one-way deal

$423 or less
Provider with most accurate pricing for Panama City Tocumen Intl-San Francisco flight deals.
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Provider most trusted by Cheapflights users for Panama City Tocumen Intl-San Francisco flights.
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From Panama City Tocumen Intl to San Francisco
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One-way flight from Panama City Tocumen Intl to San Francisco
Search Deals
Highest demand for flights based on searches. 5% potential increase in price ($37 potential increase over avg. RT price).
Search Deals
Cheapest flight prices on average. 0% potential price decrease ($6 potential savings vs. average RT price).
Search Deals
Average for round-trip flights in December 2025
Search Deals
Price to beat on a round-trip flight from Panama City Tocumen Intl to San Francisco.
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Price to beat on a one-way flight from Panama City Tocumen Intl to San Francisco.
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Cheapflights Fare Finder

 
Customize your flight search to find flights from Panama City to San Francisco that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated December 8, 2025.
Use the filters below to find and compare flights from Panama City to San Francisco that are best for you.

Fly from

Panama City

Fly to

San Francisco

Route

Depart

Return

Price

Panama CitySan Francisco

PTY - SFO

PTYSFO

Panama City Tocumen Intl

Fri 2/13

2:55 am-11:20 pm

2 stops23h 25m

San Francisco

Wed 2/18

1:20 pm-8:50 am

2 stops16h 30m

$491

Panama CitySan Francisco

PTY - SFO

PTYSFO

Panama City Tocumen Intl

Thu 1/22

9:45 am-11:20 pm

2 stops16h 35m

San Francisco

Thu 1/29

11:10 pm-6:55 pm

1 stop16h 45m

$500

Panama CitySan Francisco

PTY - SFO

PTYSFO

Panama City Tocumen Intl

Sun 2/1

7:50 pm-12:00 pm

1 stop19h 10m

San Francisco

Mon 2/9

1:20 pm-8:50 am

2 stops16h 30m

$508

Panama CitySan Francisco

PTY - SFO

PTYSFO

Panama City Tocumen Intl

Tue 1/20

2:46 pm-11:51 am

1 stop24h 05m

San Francisco

Tue 1/27

11:10 pm-10:30 am

1 stop8h 20m

$565

Panama CitySan Francisco

PTY - SFO

PTYSFO

Panama City Tocumen Intl

Sat 2/14

6:27 pm-11:20 pm

Nonstop7h 53m

San Francisco

Tue 2/17

12:42 am-10:46 am

Nonstop7h 04m

$665

Panama CitySan Francisco

PTY - SFO

PTYSFO

Panama City Tocumen Intl

Wed 1/21

6:27 pm-11:20 pm

Nonstop7h 53m

San Francisco

Tue 1/27

12:42 am-10:46 am

Nonstop7h 04m

$693

Panama CitySan Francisco

PTY - SFO

PTYSFO

Panama City Tocumen Intl

Sun 12/14

5:50 pm-9:50 pm

2 stops31h 00m

$277

Panama CitySan Francisco

PTY - SFO

PTYSFO

Panama City Tocumen Intl

Sat 1/31

9:45 am-11:20 pm

2 stops16h 35m

$284

Panama CitySan Francisco

PTY - SFO

PTYSFO

Panama City Tocumen Intl

Sun 2/22

2:55 pm-12:00 pm

2 stops24h 05m

$286

Panama CitySan Francisco

PTY - SFO

PTYSFO

Panama City Tocumen Intl

Sat 1/24

5:50 pm-9:50 pm

2 stops31h 00m

$286

Flights are sorted by cheapest round-trip flights first.

Deals found on 12/7

Showing 1-10 of 12 results
1
2

Compare providers for flights from Panama City to San Francisco

Provider information is updated monthly. Please note that these providers often have deals for this flight, but the availability may vary on a day-by-day basis on Cheapflights.
Use the table below to compare price accuracy, trust ratings, and cancellation policies for each provider offering flight deals from Panama City to San Francisco in December.
ProviderPrice AccuracyTrust Score*
ExpediaPrice Accuracy2 starsTrust Score*3 stars
FlightHubPrice Accuracy3 starsTrust Score*1 star
eDreamsPrice Accuracy3 starsTrust Score*3 stars
AranGrantPrice Accuracy2 starsTrust Score*3 stars

*The Trust Score is based on feedback from users after their booking experience. It measures overall satisfaction, helping us identify issues like hidden fees, problems during the ticketing process, and the quality of customer service. This score is our best indicator of the provider's quality and reliability.

  • Most accurate provider: When it comes to deals on Panama City-San Francisco flights, users find the pricing of eDreams to be most consistent on Cheapflights vs. eDreams Users can find the same prices on Panama City-San Francisco flight deals on Cheapflights vs. eDreams >95% of the time. Price accuracy is based on data collected from Panama City-San Francisco flight searches over the past month and is updated monthly.
  • Most trusted provider: When it comes to deals on Panama City-San Francisco flights, Cheapflights users trust eDreams the most. eDreams has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for Panama City-San Francisco flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.

Best time to book a flight from Panama City to San Francisco

Have a flexible travel schedule? Discover the best time to fly to San Francisco from Panama City with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Panama City to San Francisco

How far ahead should I book a flight from Panama City to San Francisco?

Use this chart to determine the optimal time to book a round-trip flight from Panama City to San Francisco. Price data was last updated on December 5, 2025.

The price you pay for your flight from Panama City to San Francisco may vary depending on when you book. For the best chance of a lower fare, look to book 64 days in advance of your trip. Fares are likely to increase a fortnight or so before your departure date.

What is the cheapest month to book a flight from Panama City to San Francisco?

Currently, August is the cheapest month in which you can book a flight from Panama City to San Francisco (average of $213). Flying from Panama City to San Francisco in February is currently the most expensive (average of $538). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from PTY to SFO?

Find hourly flight availability from Panama City to San Francisco. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated December 8, 2025.

Unlike in the afternoon, when flights are generally more expensive, you can save up to 42% on flights from Panama City to San Francisco by exploring options for tickets in the evening.

The best insider tips for Panama City to San Francisco flights

AI-powered summary based on content written by travel experts. AI can make mistakes.
Cheapflights partnered with top experts to bring you the best recommendations for your Panama City to San Francisco trip
Airports
PTY

For US-bound flights, expect two security checks at PTY, with the second at the gate. Allow extra time for this process.

Read more about PTYby Taryn White
SFO

Use BART for affordable travel from SFO to downtown San Francisco. The trip takes about 40 minutes and starts from the Garage G/Bart station.

Read more about SFOby Harriet Baskas
Our travel experts
Taryn White

Taryn White

Expert on PTY

Taryn White

Taryn White

Taryn White is a freelance travel writer, digital creator, and travel advisor who has visited nearly 100 countries and all 50 states. She’s familiar with many airports and enjoys beach hopping, boutique hotels, spa experiences, and exploring local culture. Her work has appeared in Travel + Leisure, Condé Nast Traveler, National Geographic, Smithsonian Magazine, AFAR, and more.

Read more
Harriet Baskas

Harriet Baskas

Expert on SFO

Harriet Baskas

Harriet Baskas

Harriet is an award-winning journalist who is happiest in an airport or an unusual museum. Her stories about airports, air travel, and the business of travel have appeared on NBC News, CNBC, USA TODAY, The Points Guy and other outlets. She is the creator of the StuckatTheAirport.com blog and the author of nine books. When not out on the road or exploring the latest airport amenities, she’s home in Seattle getting ready for the next adventure.

Read more

Reviews of airlines servicing San Francisco

Get insights into the airlines that provide service to San Francisco. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to San Francisco. Reviews last updated December 8, 2025.
Read through reviews of airlines operating flights from Panama City to San Francisco, such as Copa Airlines, United Airlines, and Avianca. You can also see how each airline stacks up in terms of entertainment options, comfort, food, crew/service, and boarding process.
Copa Airlines
7.6
Good
1,557 reviews

Boarding

7.8

Comfort

7.4

Crew

8.1

Overall

7.6

Food

6.9

Entertainment

6.8

Reviews

1 / 20
4.0
Okay

Juan Pablo,Sep 2025

PTY - VVI

not a good expirience, the plane was packed, the seats wear very unconftrable, coudent conect with the entratainmente service on the plane, the onboarding was in charge of a very angry lady i really had a unplesent trip
Copa Airlines
7.6
Good
1,557 reviews
Copa Airlines
7.6
Good
1,557 reviews

Boarding

7.8

Comfort

7.4

Crew

8.1

Overall

7.6

Food

6.9

Entertainment

6.8

Reviews

1 / 20
4.0
Okay

Juan Pablo,Sep 2025

PTY - VVI

not a good expirience, the plane was packed, the seats wear very unconftrable, coudent conect with the entratainmente service on the plane, the onboarding was in charge of a very angry lady i really had a unplesent trip
United Airlines
7.4
Good
9,079 reviews
Copa Airlines
7.6
Good
1,557 reviews

Boarding

7.8

Comfort

7.4

Crew

8.1

Overall

7.6

Food

6.9

Entertainment

6.8

Reviews

1 / 20
4.0
Okay

Juan Pablo,Sep 2025

PTY - VVI

not a good expirience, the plane was packed, the seats wear very unconftrable, coudent conect with the entratainmente service on the plane, the onboarding was in charge of a very angry lady i really had a unplesent trip
Avianca
6.6
Okay
2,475 reviews
Copa Airlines
7.6
Good
1,557 reviews

Boarding

7.8

Comfort

7.4

Crew

8.1

Overall

7.6

Food

6.9

Entertainment

6.8

Reviews

1 / 20
4.0
Okay

Juan Pablo,Sep 2025

PTY - VVI

not a good expirience, the plane was packed, the seats wear very unconftrable, coudent conect with the entratainmente service on the plane, the onboarding was in charge of a very angry lady i really had a unplesent trip

Related info for your journey

Find useful and relevant information for your journey from Panama City to San Francisco. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airports do I use to fly from Panama City to San Francisco?

    If you book a flight from Panama City to San Francisco, you will be flying from Tocumen Intl to San Francisco. Flights to San Francisco (SFO) from Panama City Tocumen Intl (PTY) take 7h 36m for a nonstop flight. There are 3 flights from Tocumen Intl to San Francisco per day from 3 airlines.

  • How popular is this Panama City to San Francisco flight route?

    The Panama City Tocumen Intl to San Francisco flight path was viewed by 1 users in the past month. Keep an eye out for changes in search interest prior to high and low season.

  • How long is the flight from Panama City to San Francisco?

    There are many flights that can get you from Panama City to San Francisco in 23h 25m. Fly via Avianca to get the fastest option. The distance between Panama City and San Francisco is about 3318 mi.

  • What are the cheapest airlines flying from Panama City to San Francisco round-trip?

    Cheapflights users have booked flights from Panama City to San Francisco round-trip from $335. Other airlines that can offer you cheap pricing are Avianca, from $465, and United Airlines, from $506. Copa Airlines is priced at 47% lower than the current average price of a flight leaving 3 months from now.

  • What are the cheapest airlines to fly from Panama City to San Francisco one-way?

    The cheapest airlines for a one-way flight from Panama City to San Francisco are Avianca ($271), American Airlines ($329), and United Airlines ($517).

  • What are the cheapest flights from Panama City to San Francisco?

    The cheapest flight price from Panama City to San Francisco is $367. On average you can expect to pay $606. The most popular route, (Panama City Tocumen Intl - San Francisco), can usually be booked for $564.

  • Can I find deals for flights from Panama City to San Francisco that include hotel bookings?

    Yes. In addition to deals on Panama City to San Francisco flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Panama City to San Francisco?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Panama City to San Francisco.

  • Can I find deals for business class flights from Panama City to San Francisco?

    Yes. Cheapflights offers flight deals from Panama City to San Francisco by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Panama City to San Francisco?

    Currently, August is the cheapest month in which you can book a flight from Panama City to San Francisco (average of $213). Flying from Panama City to San Francisco in February is currently the most expensive (average of $538). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Traveling to a place near San Francisco?

Book flights to San Francisco if you plan to visit one of these locations
Roseville
South San Francisco
Santa Cruz
Livermore
Turlock
Manteca
Watsonville
Sunnyvale
Santa Clara
San Bruno
Redwood City
Daly City
Vallejo
Hollister
Foster City
Union City
Davis
San Ramon
Burlingame
Milpitas

Browse thousands of different options on Cheapflights for your next trip

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Top 3 airlines flying from Panama City to San Francisco

Discover the top 3 airlines that operate flights from Panama City to San Francisco. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated December 8, 2025.
AirlineCheapestAverageFlexibilityOn-time
AviancaCheapest$465Average$534FlexibilityNo cancel feeOn-time71%
United AirlinesCheapest$506Average$664FlexibilityNo cancel feeOn-time69%
Copa AirlinesCheapest$506Average$652FlexibilityNo cancel feeOn-time70%

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