$355+ Cheap flights from Panama City (PTY) to San Francisco (SFO)
This is the cheapest round-trip flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 12/6. Fares are subject to change and may not be available on all flights or dates of travel.
PTY — SFO
Dec 2 — Dec 91
Round-trip
1 adult, Economy
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Find cheap flights from Panama City to San Francisco with Cheapflights
1. Tell us where you want to go
Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”2. Select your favorite providers
We find the providers serving your travel needs. Choose up to four travel providers to compare side-by-side for flights, hotels, or car rentals.3. Compare prices and book
Review each provider’s pricing and select the best option for you! Book through your favorite provider’s website for a seamless experience.Cheapflights Tip: The best prices from Panama City Tocumen Intl to San Francisco are usually found in April or January, booked 37 days in advance, depart on a Wednesday or Monday and return on a Wednesday
Cheap flight deals from Panama City to San Francisco
Cheapest
Best
Last-minute
One-way
Cheapest flights from Panama City to San FranciscoExplore the most affordable flight options available from Panama City to San Francisco. Find the lowest fares from popular airlines and budget airlines, with prices last updated on November 2, 2026.
Explore the most affordable flight options available from Panama City to San Francisco. Find the lowest fares from popular airlines and budget airlines, with prices last updated on November 2, 2026.
This Avianca deal was found by Cheapflights users on 10/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Avianca is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/305:30 am -
1 stop9h 25m
Mon 11/911:00 pm -
2 stops13h 15m
Deal found 10/29![Avianca logo]()
$682
This Copa Airlines deal was found by Cheapflights users on 10/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Copa Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 11/36:31 pm -
Nonstop7h 41m
Sun 11/812:33 am -
Nonstop7h 13m
Deal found 10/30![Copa Airlines logo]()
$730
This United Airlines deal was found by Cheapflights users on 10/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 11/34:41 pm -
1 stop22h 38m
Mon 11/95:00 am -
1 stop11h 38m
Deal found 10/30![United Airlines logo]()
$735
This American Airlines deal was found by Cheapflights users on 11/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 12/224:33 pm -
1 stop21h 29m
Thu 1/710:17 pm -
1 stop14h 04m
Deal found 11/1![American Airlines logo]()
$742
This United Airlines deal was found by Cheapflights users on 10/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 11/238:55 am -
1 stop18h 09m
Fri 11/2711:59 pm -
1 stop16h 39m
Deal found 10/29![United Airlines logo]()
$744
This American Airlines deal was found by Cheapflights users on 11/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/234:33 pm -
1 stop21h 29m
Thu 2/46:39 pm -
2 stops18h 16m
Deal found 11/2![American Airlines logo]()
$747
This American Airlines deal was found by Cheapflights users on 10/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/234:33 pm -
1 stop21h 29m
Thu 1/710:07 pm -
1 stop14h 48m
Deal found 10/31![American Airlines logo]()
$753
This American Airlines deal was found by Cheapflights users on 10/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 11/113:13 pm -
2 stops20h 27m
Wed 11/255:22 pm -
2 stops18h 12m
Deal found 10/31![American Airlines logo]()
$756
This Orbitz deal was found by Cheapflights users on 11/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Orbitz is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 11/36:10 pm -
2 stops30h 30m
Tue 11/101:15 pm -
1 stop9h 55m
Deal found 11/1![Avianca logo]()
$765
Best flights from Panama City to San FranciscoDiscover carefully curated flight deals from Panama City to San Francisco that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated November 2, 2026.
Discover carefully curated flight deals from Panama City to San Francisco that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated November 2, 2026.
This Copa Airlines deal was found by Cheapflights users on 10/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Copa Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 11/96:31 pm -
Nonstop7h 41m
Thu 11/127:36 pm -
Nonstop7h 10m
Deal found 10/29![Copa Airlines logo]()
$730
This United Airlines deal was found by Cheapflights users on 10/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 11/204:41 pm -
1 stop17h 47m
Mon 11/236:35 pm -
1 stop22h 03m
Deal found 10/31![United Airlines logo]()
$735
This Delta deal was found by Cheapflights users on 10/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/53:24 pm -
1 stop11h 32m
Sat 11/710:25 pm -
1 stop12h 34m
Deal found 10/28![Delta logo]()
$735
This Copa Airlines deal was found by Cheapflights users on 10/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Copa Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 11/206:31 pm -
Nonstop7h 41m
Sun 11/2212:33 am -
Nonstop7h 13m
Deal found 10/30![Copa Airlines logo]()
$730
This United Airlines deal was found by Cheapflights users on 10/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 11/94:41 pm -
1 stop21h 05m
Thu 11/126:35 pm -
1 stop22h 03m
Deal found 10/30![United Airlines logo]()
$735
This Delta deal was found by Cheapflights users on 10/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 11/113:29 pm -
1 stop11h 29m
Wed 11/2511:59 pm -
1 stop11h 03m
Deal found 10/31![Delta logo]()
$735
This United Airlines deal was found by Cheapflights users on 10/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 11/238:55 am -
1 stop18h 09m
Fri 11/2711:59 pm -
1 stop16h 39m
Deal found 10/29![United Airlines logo]()
$744
Last-minute flights from Panama City to San FranciscoDiscover last-minute flight deals from Panama City to San Francisco. Data last updated November 2, 2026 and is based on user searches.
Discover last-minute flight deals from Panama City to San Francisco. Data last updated November 2, 2026 and is based on user searches.
This Avianca deal was found by Cheapflights users on 10/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Avianca is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/305:30 am -
1 stop9h 25m
Mon 11/911:00 pm -
2 stops13h 15m
Deal found 10/29![Avianca logo]()
$682
This Copa Airlines deal was found by Cheapflights users on 10/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Copa Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 11/36:31 pm -
Nonstop7h 41m
Sun 11/812:33 am -
Nonstop7h 13m
Deal found 10/30![Copa Airlines logo]()
$730
This United Airlines deal was found by Cheapflights users on 10/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 11/34:41 pm -
1 stop22h 38m
Mon 11/95:00 am -
1 stop11h 38m
Deal found 10/30![United Airlines logo]()
$735
This Orbitz deal was found by Cheapflights users on 11/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Orbitz is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 11/36:10 pm -
2 stops30h 30m
Tue 11/101:15 pm -
1 stop9h 55m
Deal found 11/1![Avianca logo]()
$765
This Travelocity deal was found by Cheapflights users on 10/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Travelocity is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 11/36:10 pm -
2 stops30h 30m
Mon 11/911:00 pm -
1 stop24h 10m
Deal found 10/31![Avianca logo]()
$782
This KAYAK deal was found by Cheapflights users on 11/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure KAYAK is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 11/34:41 pm -
1 stop10h 23m
Tue 11/106:42 pm -
1 stop17h 03m
Deal found 11/1![Copa Airlines logo]()
$794
This Copa Airlines deal was found by Cheapflights users on 11/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Copa Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 11/312:44 pm -
Nonstop7h 41m
Wed 11/117:36 pm -
Nonstop7h 10m
Deal found 11/2![Copa Airlines logo]()
$808
This American Airlines deal was found by Cheapflights users on 10/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 11/113:13 pm -
2 stops20h 27m
Wed 11/255:22 pm -
2 stops18h 12m
Deal found 10/31![American Airlines logo]()
$756
This oojo deal was found by Cheapflights users on 10/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure oojo is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 11/136:31 pm -
Nonstop7h 41m
Sun 11/1512:33 am -
Nonstop7h 13m
Deal found 10/31![Copa Airlines logo]()
$786
This Avianca deal was found by Cheapflights users on 10/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Avianca is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 11/2010:05 am -
2 stops14h 35m
Mon 11/231:15 pm -
2 stops16h 55m
Deal found 10/30![Avianca logo]()
$811
This United Airlines deal was found by Cheapflights users on 10/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 11/238:55 am -
1 stop18h 09m
Fri 11/2711:59 pm -
1 stop16h 39m
Deal found 10/29![United Airlines logo]()
$744
One-way flights from Panama City to San FranciscoSearch for one-way flight options from Panama City to San Francisco. Find affordable one-way fares based on user searches. Data last updated November 2, 2026.
Search for one-way flight options from Panama City to San Francisco. Find affordable one-way fares based on user searches. Data last updated November 2, 2026.
This Kiwi.com deal was found by Cheapflights users on 10/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 12/64:00 pm -
3 stops48h 27m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 10/30![Multiple Airlines logo]()
$355
This Kiwi.com deal was found by Cheapflights users on 10/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 12/19:31 pm -
2 stops38h 45m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 10/29![Multiple Airlines logo]()
$378
This Copa Airlines deal was found by Cheapflights users on 10/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Copa Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 11/76:31 pm -
Nonstop7h 41m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 10/29![Copa Airlines logo]()
$395
This Delta deal was found by Cheapflights users on 10/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 11/73:24 pm -
1 stop11h 32m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 10/29![Delta logo]()
$401
This American Airlines deal was found by Cheapflights users on 10/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 1/214:55 pm -
1 stop21h 20m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 10/29![American Airlines logo]()
$404
This American Airlines deal was found by Cheapflights users on 10/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 11/73:13 pm -
2 stops24h 54m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 10/29![American Airlines logo]()
$410
This American Airlines deal was found by Cheapflights users on 10/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 11/183:13 pm -
2 stops24h 58m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 10/29![American Airlines logo]()
$411
This Kiwi.com deal was found by Cheapflights users on 10/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 12/79:31 pm -
3 stops25h 37m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 10/30![Multiple Airlines logo]()
$413
Find flight deals from Panama City to San Francisco
Discover tips and strategies to find the most affordable flight options for your journey from Panama City (PTY) to San Francisco (SFO). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated November 2, 2026.
Most accurate provider | FlightHub 3 stars |
|---|---|
Most trusted provider | FlightHub 3 stars |
Round-trip from | $730 (Copa Airlines) |
One-way from | $355 (Kiwi.com) |
Popular in | December |
Cheapest in | April |
Average price | $819 |
Good round-trip deal | $729 or less |
Good one-way deal | $576 or less |
Cheapflights Fare Finder
Customize your flight search to find flights from Panama City to San Francisco that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 7,457,451 searches. Data last updated November 2, 2026.
Use the filters below to find and compare flights from Panama City to San Francisco that are best for you.
Fly from
Fly to
Route
Depart
Return
Cheapest round-trip
Panama CitySan Francisco
PTY Panama City Tocumen Intl - SFO San Francisco
PTYSFO
Panama City Tocumen Intl
Tue 12/1
6:31 pm-11:17 pm
Nonstop7h 46m
San Francisco
Wed 12/31
12:00 am-3:00 am
Nonstop0h 00m
$395
Panama CitySan Francisco
PTY Panama City Tocumen Intl - SFO San Francisco
PTYSFO
Panama City Tocumen Intl
Wed 11/18
4:41 pm-12:19 pm
1 stop22h 38m
San Francisco
Wed 12/31
12:00 am-3:00 am
Nonstop0h 00m
$401
Panama CitySan Francisco
PTY Panama City Tocumen Intl - SFO San Francisco
PTYSFO
Panama City Tocumen Intl
Sat 11/7
3:24 pm-11:56 pm
1 stop11h 32m
San Francisco
Wed 12/31
12:00 am-3:00 am
Nonstop0h 00m
$401
Panama CitySan Francisco
PTY Panama City Tocumen Intl - SFO San Francisco
PTYSFO
Panama City Tocumen Intl
Tue 12/1
4:41 pm-3:04 pm
1 stop25h 23m
San Francisco
Wed 12/31
12:00 am-3:00 am
Nonstop0h 00m
$401
Panama CitySan Francisco
PTY Panama City Tocumen Intl - SFO San Francisco
PTYSFO
Panama City Tocumen Intl
Sat 12/5
4:41 pm-3:04 pm
1 stop25h 23m
San Francisco
Wed 12/31
12:00 am-3:00 am
Nonstop0h 00m
$401
Panama CitySan Francisco
PTY Panama City Tocumen Intl - SFO San Francisco
PTYSFO
Panama City Tocumen Intl
Thu 1/21
4:55 pm-11:15 am
1 stop21h 20m
San Francisco
Wed 12/31
12:00 am-3:00 am
Nonstop0h 00m
$404
Panama CitySan Francisco
PTY Panama City Tocumen Intl - SFO San Francisco
PTYSFO
Panama City Tocumen Intl
Fri 1/1
5:30 am-11:55 am
1 stop9h 25m
San Francisco
Wed 12/31
12:00 am-3:00 am
Nonstop0h 00m
$685
Panama CitySan Francisco
PTY Panama City Tocumen Intl - SFO San Francisco
PTYSFO
Panama City Tocumen Intl
Mon 11/9
6:31 pm-11:12 pm
Nonstop7h 41m
San Francisco
Thu 11/12
7:36 pm-5:46 am
Nonstop7h 10m
$730
Panama CitySan Francisco
PTY Panama City Tocumen Intl - SFO San Francisco
PTYSFO
Panama City Tocumen Intl
Fri 11/20
6:31 pm-11:12 pm
Nonstop7h 41m
San Francisco
Sun 11/22
12:33 am-10:46 am
Nonstop7h 13m
$730
Panama CitySan Francisco
PTY Panama City Tocumen Intl - SFO San Francisco
PTYSFO
Panama City Tocumen Intl
Fri 11/20
4:41 pm-7:28 am
1 stop17h 47m
San Francisco
Mon 11/23
6:35 pm-7:38 pm
1 stop22h 03m
$735
Showing 1-10 of 18 resultsSorted by cheapest first
Compare providers for flights from Panama City to San Francisco
Provider information is updated monthly. Please note that these providers often have deals for this flight, but the availability may vary on a day-by-day basis on Cheapflights.
Use the table below to compare price accuracy, trust ratings, and cancellation policies for each provider offering flight deals from Panama City to San Francisco in November.
| Provider | Price Accuracy | Trust Score* |
|---|---|---|
| Price Accuracy1 star | Trust Score*3 stars | |
| Price Accuracy3 stars | Trust Score*3 stars | |
| Price Accuracy2 stars | Trust Score*3 stars | |
| Price Accuracy3 stars | Trust Score*3 stars |
- Most accurate provider: When it comes to deals on Panama City-San Francisco flights, users find the pricing of FlightHub to be most consistent on Cheapflights vs. FlightHub Users can find the same prices on Panama City-San Francisco flight deals on Cheapflights vs. FlightHub >95% of the time. Price accuracy is based on data collected from Panama City-San Francisco flight searches over the past month and is updated monthly.
- Most trusted provider: When it comes to deals on Panama City-San Francisco flights, Cheapflights users trust FlightHub the most. FlightHub has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for Panama City-San Francisco flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.
Best time to book a flight from Panama City to San Francisco
Have a flexible travel schedule? Discover the best time to fly to San Francisco from Panama City with our price prediction graph.
PTY-SFO
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.
Cheapflights Insights
Everything you need to know about your flight from Panama City to San Francisco
Prices
Airlines
How far ahead should I book a flight from Panama City to San Francisco?
The price you pay for your flight from Panama City to San Francisco may vary depending on when you book. For the best chance of a lower fare, look to book 36 days in advance of your trip. Fares are likely to increase a fortnight or so before your departure date.
What is the cheapest month to book a flight from Panama City to San Francisco?
Currently, April is the cheapest month in which you can book a flight from Panama City to San Francisco (average of $624). Flying from Panama City to San Francisco in December is currently the most expensive (average of $921). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.
What is the cheapest time of day to fly from PTY to SFO?
Find hourly flight availability from Panama City to San Francisco. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated November 2, 2026.
When flying from Panama City to San Francisco, the time of day you decide to fly out makes little to no difference towards the overall price you’ll pay on tickets.
The best insider tips for Panama City to San Francisco flights
AI-powered summary based on content written by travel experts. AI can make mistakes.
Cheapflights partnered with top experts to bring you the best recommendations for your Panama City to San Francisco trip
Our travel experts
Reviews of airlines servicing San Francisco
Get insights into the airlines that provide service to San Francisco. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to San Francisco. Reviews last updated November 2, 2026.
Read through reviews of airlines operating flights from Panama City to San Francisco, such as Copa Airlines,United Airlines, andAvianca. You can also see how each airline stacks up in terms of entertainment options, comfort, food, crew/service, and boarding process.
Entertainment
6.9
Crew
8.1
Food
7.0
Comfort
7.5
Boarding
7.8
Overall
7.6
Reviews
1 / 20
2.0
MediocreMaria,Dec 2025
PTY - SLA
Entertainment
6.9
Crew
8.1
Food
7.0
Comfort
7.5
Boarding
7.8
Overall
7.6
Reviews
1 / 20
2.0
MediocreMaria,Dec 2025
PTY - SLA
Entertainment
6.9
Crew
8.1
Food
7.0
Comfort
7.5
Boarding
7.8
Overall
7.6
Reviews
1 / 20
2.0
MediocreMaria,Dec 2025
PTY - SLA
Entertainment
6.9
Crew
8.1
Food
7.0
Comfort
7.5
Boarding
7.8
Overall
7.6
Reviews
1 / 20
2.0
MediocreMaria,Dec 2025
PTY - SLA
Related info for your journey
Find useful and relevant information for your journey from Panama City to San Francisco. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.
Traveling to a place near San Francisco?
Book flights to San Francisco if you plan to visit one of these locationsSouth San Francisco
Santa Clara
Santa Cruz
Walnut Creek
Hayward
Emeryville
Newark
Burlingame
San Bruno
Rancho Cordova
Vallejo
Cupertino
Fairfield
Redwood City
San Carlos
Sunnyvale
Turlock
Davis
Morgan Hill
Roseville
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Alternative routes for Panama City to San Francisco
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Find flights from Panama City to San Francisco, based on your preferred cabin class, be it economy, premium economy, business, or first class.
Panama City and San Francisco flights
Browse other Panama City and San Francisco flight options. Last updated on November 2, 2026.
Other flights from Panama City
Browse through other flights departing from Panama City. Flights are based on user searches made on Cheapflights and were last updated on November 2, 2026.
Popular flight searches
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Other flights to San Francisco
Explore flights to San Francisco departing from other origins. Flights are based on user searches made on Cheapflights and were last updated on November 2, 2026.
Top 3 airlines flying from Panama City to San Francisco
Discover the top 3 airlines that operate flights from Panama City to San Francisco. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 7,457,451 searches. Data last updated November 2, 2026.
| Airline | Cheapest | Average | Flexibility | On-time |
|---|---|---|---|---|
| Cheapest$281 | Average$682 | FlexibilityNo cancel fee | On-time71% | |
| Cheapest$393 | Average$762 | FlexibilityNo cancel fee | On-time70% | |
| Cheapest$679 | Average$876 | FlexibilityNo cancel fee | On-time69% |