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$266+ Cheap flights from Panama City (PTY) to San Francisco (SFO)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 3/9. Fares are subject to change and may not be available on all flights or dates of travel.
PTY — SFO
Feb 20 — Feb 271
Fri 2/20
Fri 2/27
1 adult, Economy
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Cheapflights Tip: The best prices from Panama City Tocumen Intl to San Francisco are usually found in August or September, booked 67 days in advance, depart on a Monday or Tuesday and return on a Tuesday

Cheap flight deals from Panama City to San Francisco

Cheapest flights from Panama City to San Francisco
Explore the most affordable flight options available from Panama City to San Francisco. Find the lowest fares from popular airlines and budget airlines, with prices last updated on January 21, 2026.

This Avianca deal was found by Cheapflights users on 1/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Avianca is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 2/109:45 am
PTY
-
SFO
2 stops16h 35m
Avianca
Tue 4/2111:55 pm
SFO
-
PTY
2 stops14h 35m
Avianca
Deal found 1/21$387
This Gotogate deal was found by Cheapflights users on 1/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Gotogate is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 3/112:55 am
PTY
-
SFO
2 stops21h 55m
Avianca
Wed 3/182:20 pm
SFO
-
PTY
2 stops16h 30m
Avianca
Deal found 1/19$408
This Trip.com deal was found by Cheapflights users on 1/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Trip.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 2/109:45 am
PTY
-
SFO
2 stops16h 35m
Avianca
Thu 4/2311:55 pm
SFO
-
PTY
2 stops14h 35m
Avianca
Deal found 1/20$419
This Avianca deal was found by Cheapflights users on 1/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Avianca is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 2/179:45 am
PTY
-
SFO
2 stops16h 35m
Avianca
Sun 2/2211:10 pm
SFO
-
PTY
1 stop8h 20m
Avianca
Deal found 1/19$444
This Avianca deal was found by Cheapflights users on 1/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Avianca is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 2/143:50 pm
PTY
-
SFO
1 stop10h 30m
Avianca
Tue 2/171:20 pm
SFO
-
PTY
1 stop18h 10m
Avianca
Deal found 1/19$455
This Avianca deal was found by Cheapflights users on 1/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Avianca is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 3/73:50 pm
PTY
-
SFO
1 stop10h 30m
Avianca
Sat 3/142:20 pm
SFO
-
PTY
1 stop18h 10m
Avianca
Deal found 1/21$465
This Avianca deal was found by Cheapflights users on 1/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Avianca is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 3/67:50 pm
PTY
-
SFO
1 stop19h 10m
Avianca
Fri 3/132:20 pm
SFO
-
PTY
1 stop18h 10m
Avianca
Deal found 1/20$466
This Priceline deal was found by Cheapflights users on 1/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Priceline is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 2/82:55 pm
PTY
-
SFO
2 stops24h 05m
Avianca
Thu 2/191:35 am
SFO
-
PTY
1 stop14h 20m
Avianca
Deal found 1/20$474
This Mytrip deal was found by Cheapflights users on 1/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 2/133:50 pm
PTY
-
SFO
1 stop23h 10m
Avianca
Thu 4/232:15 pm
SFO
-
PTY
1 stop9h 40m
Avianca
Deal found 1/19$492

Find flight deals from Panama City to San Francisco

Discover tips and strategies to find the most affordable flight options for your journey from Panama City (PTY) to San Francisco (SFO). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated January 21, 2026.

Most accurate provider

FlightHub
3 stars

Most trusted provider

Expedia
3 stars

Round-trip from

$387
(Avianca)

One-way from

$266
(Kiwi.com)

Popular in

February

Cheapest in

August

Average price

$670

Good round-trip deal

$411 or less

Good one-way deal

$956 or less
Provider with most accurate pricing for Panama City Tocumen Intl-San Francisco flight deals.
Search Deals
Provider most trusted by Cheapflights users for Panama City Tocumen Intl-San Francisco flights.
Search Deals
From Panama City Tocumen Intl to San Francisco
Search Deals
One-way flight from Panama City Tocumen Intl to San Francisco
Search Deals
Highest demand for flights based on searches. 12% potential increase in price ($95 potential increase over avg. RT price).
Search Deals
Cheapest flight prices on average. 3% potential price decrease ($21 potential savings vs. average RT price).
Search Deals
Average for round-trip flights in January 2026
Search Deals
Price to beat on a round-trip flight from Panama City Tocumen Intl to San Francisco.
Search Deals
Price to beat on a one-way flight from Panama City Tocumen Intl to San Francisco.
Search Deals

Cheapflights Fare Finder

 
Customize your flight search to find flights from Panama City to San Francisco that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated January 21, 2026.
Use the filters below to find and compare flights from Panama City to San Francisco that are best for you.

Fly from

Panama City

Fly to

San Francisco

Route

Depart

Return

Price

Panama CitySan Francisco

PTY - SFO

PTYSFO

Panama City Tocumen Intl

Thu 3/12

3:50 pm-11:40 pm

1 stop9h 50m

San Francisco

Wed 3/18

2:20 pm-8:50 am

2 stops16h 30m

$387

Panama CitySan Francisco

PTY - SFO

PTYSFO

Panama City Tocumen Intl

Tue 4/7

3:50 pm-11:55 pm

1 stop10h 05m

San Francisco

Tue 4/14

2:15 pm-1:55 am

1 stop9h 40m

$387

Panama CitySan Francisco

PTY - SFO

PTYSFO

Panama City Tocumen Intl

Tue 3/10

9:45 am-10:50 pm

2 stops15h 05m

San Francisco

Wed 3/18

2:20 pm-10:30 am

1 stop18h 10m

$387

Panama CitySan Francisco

PTY - SFO

PTYSFO

Panama City Tocumen Intl

Tue 2/10

3:50 pm-11:20 pm

1 stop10h 30m

San Francisco

Thu 4/23

2:15 pm-10:30 am

1 stop18h 15m

$387

Panama CitySan Francisco

PTY - SFO

PTYSFO

Panama City Tocumen Intl

Sat 3/7

9:45 am-11:20 pm

2 stops16h 35m

San Francisco

Sat 3/14

2:20 pm-10:30 am

1 stop18h 10m

$465

Panama CitySan Francisco

PTY - SFO

PTYSFO

Panama City Tocumen Intl

Fri 3/6

7:50 pm-12:00 pm

1 stop19h 10m

San Francisco

Thu 3/12

2:35 am-6:55 pm

1 stop14h 20m

$465

Panama CitySan Francisco

PTY - SFO

PTYSFO

Panama City Tocumen Intl

Sun 2/8

2:55 pm-12:00 pm

2 stops24h 05m

San Francisco

Thu 2/19

1:35 am-6:55 pm

1 stop14h 20m

$474

Panama CitySan Francisco

PTY - SFO

PTYSFO

Panama City Tocumen Intl

Mon 3/9

9:45 am-6:37 pm

3 stops58h 52m

$266

Panama CitySan Francisco

PTY - SFO

PTYSFO

Panama City Tocumen Intl

Tue 4/7

3:50 pm-11:55 pm

1 stop10h 05m

$278

Panama CitySan Francisco

PTY - SFO

PTYSFO

Panama City Tocumen Intl

Mon 3/9

5:50 pm-11:40 pm

2 stops31h 50m

$287

Flights are sorted by cheapest round-trip flights first.

Deals found on 1/20

Showing 1-10 of 16 results
1
2

Compare providers for flights from Panama City to San Francisco

Provider information is updated monthly. Please note that these providers often have deals for this flight, but the availability may vary on a day-by-day basis on Cheapflights.
Use the table below to compare price accuracy, trust ratings, and cancellation policies for each provider offering flight deals from Panama City to San Francisco in January.
ProviderPrice AccuracyTrust Score*
ExpediaPrice Accuracy2 starsTrust Score*3 stars
FlightHubPrice Accuracy3 starsTrust Score*1 star
AranGrantPrice Accuracy2 starsTrust Score*3 stars

*The Trust Score is based on feedback from users after their booking experience. It measures overall satisfaction, helping us identify issues like hidden fees, problems during the ticketing process, and the quality of customer service. This score is our best indicator of the provider's quality and reliability.

  • Most accurate provider: When it comes to deals on Panama City-San Francisco flights, users find the pricing of FlightHub to be most consistent on Cheapflights vs. FlightHub Users can find the same prices on Panama City-San Francisco flight deals on Cheapflights vs. FlightHub >95% of the time. Price accuracy is based on data collected from Panama City-San Francisco flight searches over the past month and is updated monthly.
  • Most trusted provider: When it comes to deals on Panama City-San Francisco flights, Cheapflights users trust Expedia the most. Expedia has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for Panama City-San Francisco flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.

Best time to book a flight from Panama City to San Francisco

Have a flexible travel schedule? Discover the best time to fly to San Francisco from Panama City with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Panama City to San Francisco

How far ahead should I book a flight from Panama City to San Francisco?

Use this chart to determine the optimal time to book a round-trip flight from Panama City to San Francisco. Price data was last updated on January 16, 2026.

The price you pay for your flight from Panama City to San Francisco may vary depending on when you book. For the best chance of a lower fare, look to book 64 days in advance of your trip. Fares are likely to increase a fortnight or so before your departure date.

What is the cheapest month to book a flight from Panama City to San Francisco?

Currently, August is the cheapest month in which you can book a flight from Panama City to San Francisco (average of $220). Flying from Panama City to San Francisco in February is currently the most expensive (average of $544). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from PTY to SFO?

Find hourly flight availability from Panama City to San Francisco. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated January 21, 2026.

When flying from Panama City to San Francisco, the time of day you decide to fly out makes little to no difference towards the overall price you’ll pay on tickets.

How much does it cost to fly round-trip from Panama City to San Francisco?

The best insider tips for Panama City to San Francisco flights

AI-powered summary based on content written by travel experts. AI can make mistakes.
Cheapflights partnered with top experts to bring you the best recommendations for your Panama City to San Francisco trip
Our travel experts
Taryn White

Taryn White

Expert on PTY

Taryn White is a freelance travel writer, digital creator, and travel advisor who has visited nearly 100 countries and all 50 states. She’s familiar with many airports and enjoys beach hopping, boutique hotels, spa experiences, and exploring local culture. Her work has appeared in Travel + Leisure, Condé Nast Traveler, National Geographic, Smithsonian Magazine, AFAR, and more.

Read more
Harriet Baskas

Harriet Baskas

Expert on SFO

Harriet is an award-winning journalist who is happiest in an airport or an unusual museum. Her stories about airports, air travel, and the business of travel have appeared on NBC News, CNBC, USA TODAY, The Points Guy and other outlets. She is the creator of the StuckatTheAirport.com blog and the author of nine books. When not out on the road or exploring the latest airport amenities, she’s home in Seattle getting ready for the next adventure.

Read more

Reviews of airlines servicing San Francisco

Get insights into the airlines that provide service to San Francisco. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to San Francisco. Reviews last updated January 21, 2026.
Read through reviews of airlines operating flights from Panama City to San Francisco, such as Copa Airlines, United Airlines, and Avianca. You can also see how each airline stacks up in terms of entertainment options, comfort, food, crew/service, and boarding process.
Copa Airlines
7.6
Good
1,557 reviews

Food

6.8

Crew

8.1

Overall

7.6

Comfort

7.4

Boarding

7.8

Entertainment

6.8

Reviews

1 / 20
2.0
Mediocre

Maria,Dec 2025

PTY - SLA

Old plain no entertainment , no outlet for cell or computer! And online they said you have all that! Almost 6 hrs looking to the floor..terrible expirencw and I pay a lot of money for it
Copa Airlines
7.6
Good
1,557 reviews
Copa Airlines
7.6
Good
1,557 reviews

Food

6.8

Crew

8.1

Overall

7.6

Comfort

7.4

Boarding

7.8

Entertainment

6.8

Reviews

1 / 20
2.0
Mediocre

Maria,Dec 2025

PTY - SLA

Old plain no entertainment , no outlet for cell or computer! And online they said you have all that! Almost 6 hrs looking to the floor..terrible expirencw and I pay a lot of money for it
United Airlines
7.4
Good
9,191 reviews
Copa Airlines
7.6
Good
1,557 reviews

Food

6.8

Crew

8.1

Overall

7.6

Comfort

7.4

Boarding

7.8

Entertainment

6.8

Reviews

1 / 20
2.0
Mediocre

Maria,Dec 2025

PTY - SLA

Old plain no entertainment , no outlet for cell or computer! And online they said you have all that! Almost 6 hrs looking to the floor..terrible expirencw and I pay a lot of money for it
Avianca
6.6
Okay
2,496 reviews
Copa Airlines
7.6
Good
1,557 reviews

Food

6.8

Crew

8.1

Overall

7.6

Comfort

7.4

Boarding

7.8

Entertainment

6.8

Reviews

1 / 20
2.0
Mediocre

Maria,Dec 2025

PTY - SLA

Old plain no entertainment , no outlet for cell or computer! And online they said you have all that! Almost 6 hrs looking to the floor..terrible expirencw and I pay a lot of money for it

Related info for your journey

Find useful and relevant information for your journey from Panama City to San Francisco. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airports do I use to fly from Panama City to San Francisco?

    If you book a flight from Panama City to San Francisco, you will be flying from Tocumen Intl to San Francisco. Flights to San Francisco (SFO) from Panama City Tocumen Intl (PTY) take 7h 45m for a nonstop flight. There are 2 flights from Tocumen Intl to San Francisco per day from 3 airlines.

  • How popular is this Panama City to San Francisco flight route?

    The Panama City Tocumen Intl to San Francisco flight path was viewed by 1 users in the past month. Keep an eye out for changes in search interest prior to high and low season.

  • How long is the flight from Panama City to San Francisco?

    There are many flights that can get you from Panama City to San Francisco in 9h 50m. Fly via Avianca to get the fastest option. The distance between Panama City and San Francisco is about 3318 mi.

  • What are the cheapest airlines flying from Panama City to San Francisco round-trip?

    Cheapflights users have booked flights from Panama City to San Francisco round-trip from $200. Other airlines that can offer you cheap pricing are Copa Airlines, from $335, and United Airlines, from $506. Avianca is priced at 69% lower than the current average price of a flight leaving 3 months from now.

  • What are the cheapest airlines to fly from Panama City to San Francisco one-way?

    The cheapest airlines for a one-way flight from Panama City to San Francisco are Avianca ($273), United Airlines ($461), and Copa Airlines ($519).

  • What are the cheapest flights from Panama City to San Francisco?

    The cheapest flight price from Panama City to San Francisco is $348. On average you can expect to pay $796. The most popular route, (Panama City Tocumen Intl - San Francisco), can usually be booked for $387.

  • Can I find deals for flights from Panama City to San Francisco that include hotel bookings?

    Yes. In addition to deals on Panama City to San Francisco flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Panama City to San Francisco?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Panama City to San Francisco.

  • Can I find deals for business class flights from Panama City to San Francisco?

    Yes. Cheapflights offers flight deals from Panama City to San Francisco by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Panama City to San Francisco?

    Currently, August is the cheapest month in which you can book a flight from Panama City to San Francisco (average of $220). Flying from Panama City to San Francisco in February is currently the most expensive (average of $544). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Traveling to a place near San Francisco?

Book flights to San Francisco if you plan to visit one of these locations
South San Francisco
Santa Cruz
Roseville
Santa Clara
Livermore
Watsonville
San Bruno
Daly City
Sunnyvale
Vacaville
Turlock
San Carlos
San Ramon
Manteca
Vallejo
San Lorenzo
Davis
Hollister
Redwood City
Union City

Browse thousands of different options on Cheapflights for your next trip

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Top 3 airlines flying from Panama City to San Francisco

Discover the top 3 airlines that operate flights from Panama City to San Francisco. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated January 21, 2026.
AirlineCheapestAverageFlexibilityOn-time
AviancaCheapest$200Average$534FlexibilityNo cancel feeOn-time71%
Copa AirlinesCheapest$335Average$648FlexibilityNo cancel feeOn-time70%
United AirlinesCheapest$506Average$674FlexibilityNo cancel feeOn-time69%

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