How popular is this Panama City to San Francisco flight route?

The Panama City Tocumen Intl to San Francisco flight path was viewed by 1 users in the past month. Keep an eye out for changes in search interest prior to high and low season.

How long is the flight from Panama City to San Francisco?

There are many flights that can get you from Panama City to San Francisco in 7h 50m. Fly via Avianca, Copa Airlines, or Delta to get the fastest option. The distance between Panama City and San Francisco is about 3318 mi. Both multi-stop and nonstop flights can be found to your destination and back.

What are the cheapest airlines flying from Panama City to San Francisco round-trip?

Cheapflights users have booked flights from Panama City to San Francisco round-trip from $465. Other airlines that can offer you cheap pricing are United Airlines, from $506, and Copa Airlines, from $506. Avianca is priced at 25% lower than the current average price of a flight leaving 3 months from now.

Weekly flight availability from Panama City to San Francisco

The most flights from PTY to SFO are scheduled on a Wednesday (5 on average). You will have fewer flight options on Monday, which is when the least amount of flights are scheduled (4 on average).

In terms of precipitation, rainfall in San Francisco ranges from 0.0 - 4.4 inches per month. January is typically the wettest month, when rainfall can reach 4.4 in. July is typically the driest time to visit San Francisco when rainfall is around 0.0 in.

If weather is an important factor for your trip to San Francisco, use this chart to help with planning. For those seeking warmer temperatures, September is the ideal time of year to visit, when temperatures reach an average of 62.6 F. Travelers looking to avoid the cold should look outside of January, when temperatures are typically at their lowest (around 51.8 F).

What are the cheapest flights from Panama City to San Francisco?

The cheapest flight price from Panama City to San Francisco is $330. On average you can expect to pay $818. The most popular route, (Panama City Tocumen Intl - San Francisco), can usually be booked for $579.

What are the most popular airlines that fly from Panama City to San Francisco?

When booking a flight from Panama City to San Francisco, you may want to consider flying on Copa Airlines, United Airlines or Avianca as they are the most popular for this route.

Most accurate provider : When it comes to deals on Panama City-San Francisco flights, users find the pricing of FlightHub to be most consistent on Cheapflights vs. FlightHub Users can find the same prices on Panama City-San Francisco flight deals on Cheapflights vs. FlightHub >95% of the time. Price accuracy is based on data collected from Panama City-San Francisco flight searches over the past month and is updated monthly.

Most trusted provider : When it comes to deals on Panama City-San Francisco flights, Cheapflights users trust FlightHub the most. FlightHub has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for Panama City-San Francisco flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.

What airports do I use to fly from Panama City to San Francisco?

If you book a flight from Panama City to San Francisco, you will be flying from Tocumen Intl to San Francisco. Flights to San Francisco (SFO) from Panama City Tocumen Intl (PTY) take 7h 35m for a nonstop flight. There are 4 flights from Tocumen Intl to San Francisco per day from 3 airlines.

Can I find deals for flights from Panama City to San Francisco that include hotel bookings?

Yes. In addition to deals on Panama City to San Francisco flights, Cheapflights offers vacation packages that include both flights and hotel.

How can I find direct flights from Panama City to San Francisco?

After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Panama City to San Francisco.

Can I find deals for business class flights from Panama City to San Francisco?

Yes. Cheapflights offers flight deals from Panama City to San Francisco by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

$264+ Flights from Panama City to San Francisco

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Find cheap flights from Panama City to San Francisco with Cheapflights

1. Tell us where you want to go

Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”

2. Select your favorite providers

We find the providers serving your travel needs. Choose up to four travel providers to compare side-by-side for flights, hotels, or car rentals.

3. Compare prices and book

Review each provider’s pricing and select the best option for you! Book through your favorite provider’s website for a seamless experience.

Cheapflights Tip: The best prices from Panama City Tocumen Intl to San Francisco are usually found in August or September, booked 67 days in advance, depart on a Monday or Saturday and return on a Tuesday

Cheap flight deals from Panama City to San Francisco

Most accurate provider	FlightHub 3 stars
Most trusted provider	FlightHub 3 stars
Round-trip from	$473 (Cheapflightsfares)
One-way from	$264 (Cheapflightsfares)
Popular in	March
Cheapest in	August
Average price	$648
Good round-trip deal	$650 or less
Good one-way deal	$402 or less

Provider with most accurate pricing for Panama City Tocumen Intl-San Francisco flight deals.

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Provider most trusted by Cheapflights users for Panama City Tocumen Intl-San Francisco flights.

Search Deals

From Panama City Tocumen Intl to San Francisco

Search Deals

One-way flight from Panama City Tocumen Intl to San Francisco

Search Deals

Highest demand for flights based on searches. 4% potential increase in price ($28 potential increase over avg. RT price).

Search Deals

Cheapest flight prices on average. 0% potential price decrease ($6 potential savings vs. average RT price).

Search Deals

Average for round-trip flights in October 2025

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Price to beat on a round-trip flight from Panama City Tocumen Intl to San Francisco.

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Price to beat on a one-way flight from Panama City Tocumen Intl to San Francisco.

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Find flight deals from Panama City to San Francisco

Cheapest flights from Panama City to San Francisco
Explore the most affordable flight options available from Panama City to San Francisco. Find the lowest fares from popular airlines and budget airlines, with prices last updated on October 16, 2025.

Sun 10/1910:05 pmPTY - SFO

2 stops16h 30mAvianca

Mon 10/2012:05 amSFO - PTY

2 stops19h 05mAvianca

Deal found 10/15

$473

Thu 10/163:20 amPTY - SFO

2 stops21h 25mAvianca

Sun 10/262:20 pmSFO - PTY

2 stops16h 30mAvianca

Deal found 10/14

$482

Thu 10/233:40 pmPTY - SFO

1 stop9h 05mAvianca

Fri 11/281:20 pmSFO - PTY

2 stops21h 40mAvianca

Deal found 10/15

$494

Thu 11/139:45 amPTY - SFO

2 stops15h 05mAvianca

Mon 11/1711:10 pmSFO - PTY

1 stop8h 20mAvianca

Deal found 10/15

$500

Sat 11/13:50 pmPTY - SFO

1 stop10h 30mAvianca

Wed 11/511:10 pmSFO - PTY

1 stop8h 20mAvianca

Deal found 10/15

$514

Wed 11/57:50 pmPTY - SFO

1 stop19h 10mAvianca

Sat 11/81:20 pmSFO - PTY

1 stop18h 10mAvianca

Deal found 10/15

$520

Best flights from Panama City to San Francisco
Discover carefully curated flight deals from Panama City to San Francisco that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated October 16, 2025.

Thu 11/133:50 pmPTY - SFO

1 stop10h 30mAvianca

Tue 11/181:20 pmSFO - PTY

1 stop18h 10mAvianca

Deal found 10/15

$566

Sun 12/76:27 pmPTY - SFO

Nonstop7h 50mCopa Airlines

Mon 12/2912:36 amSFO - PTY

Nonstop7h 10mCopa Airlines

Deal found 10/16

$649

Sun 12/143:46 pmPTY - SFO

1 stop11h 34mDelta

Fri 1/26:00 amSFO - PTY

1 stop11h 00mDelta

Deal found 10/16

$655

Sun 12/143:35 pmPTY - SFO

Nonstop7h 54mUnited Airlines

Thu 1/87:10 pmSFO - PTY

1 stop16h 35mUnited Airlines

Deal found 10/16

$664

Fri 10/312:55 amPTY - SFO

2 stops23h 25mAvianca

Sat 11/291:35 amSFO - PTY

1 stop14h 20mAvianca

Deal found 10/15

$589

Thu 11/69:45 amPTY - SFO

2 stops15h 05mAvianca

Fri 11/711:10 pmSFO - PTY

1 stop8h 20mAvianca

Deal found 10/15

$596

Fri 12/123:35 pmPTY - SFO

Nonstop7h 54mUnited Airlines

Sat 1/312:25 amSFO - PTY

1 stop11h 20mUnited Airlines

Deal found 10/16

$664

Sun 12/143:35 pmPTY - SFO

Nonstop7h 54mUnited Airlines

Sat 1/312:25 amSFO - PTY

1 stop11h 20mUnited Airlines

Deal found 10/16

$664

Sun 12/73:35 pmPTY - SFO

Nonstop7h 54mUnited Airlines

Tue 12/308:45 amSFO - PTY

Nonstop7h 04mUnited Airlines

Deal found 10/16

$664

Thu 12/113:35 pmPTY - SFO

Nonstop7h 54mUnited Airlines

Sat 1/312:25 amSFO - PTY

1 stop11h 20mUnited Airlines

Deal found 10/16

$664

Sun 12/143:35 pmPTY - SFO

Nonstop7h 54mUnited Airlines

Mon 1/58:45 amSFO - PTY

Nonstop7h 04mUnited Airlines

Deal found 10/16

$664

Last-minute flights from Panama City to San Francisco
Discover last-minute flight deals from Panama City to San Francisco. Data last updated October 16, 2025 and is based on user searches.

Thu 10/163:20 amPTY - SFO

2 stops21h 25mAvianca

Sun 10/262:20 pmSFO - PTY

2 stops16h 30mAvianca

Deal found 10/14

$482

Sun 10/193:40 pmPTY - SFO

1 stop9h 05mAvianca

Tue 10/212:20 pmSFO - PTY

2 stops17h 50mAvianca

Deal found 10/15

$473

Thu 10/233:40 pmPTY - SFO

1 stop9h 05mAvianca

Fri 11/281:20 pmSFO - PTY

2 stops21h 40mAvianca

Deal found 10/15

$494

Sat 11/13:50 pmPTY - SFO

1 stop10h 30mAvianca

Wed 11/511:10 pmSFO - PTY

1 stop8h 20mAvianca

Deal found 10/16

$514

Wed 11/57:50 pmPTY - SFO

1 stop19h 10mAvianca

Sat 11/81:20 pmSFO - PTY

1 stop18h 10mAvianca

Deal found 10/15

$520

Thu 11/139:45 amPTY - SFO

2 stops15h 05mAvianca

Mon 11/1711:10 pmSFO - PTY

1 stop8h 20mAvianca

Deal found 10/15

$500

One-way flights from Panama City to San Francisco
Search for one-way flight options from Panama City to San Francisco. Find affordable one-way fares based on user searches. Data last updated October 16, 2025.

Thu 10/239:55 amPTY - SFO

2 stops14h 50mAvianca

Deal found 10/14

$264

Mon 1/195:50 pmPTY - SFO

2 stops32h 30mAvianca

Deal found 10/15

$287

Wed 12/247:50 pmPTY - SFO

1 stop19h 10mAvianca

Deal found 10/15

$297

Sun 2/227:50 pmPTY - SFO

1 stop19h 10mAvianca

Deal found 10/15

$310

Mon 1/193:02 pmPTY - SFO

1 stop23h 28mAeromexico

Deal found 10/15

$347

Mon 12/291:45 pmPTY - SFO

1 stop11h 18mMultiple Airlines

Deal found 10/15

$349

Mon 10/278:40 amPTY - SFO

2 stops16h 10mMultiple Airlines

Deal found 10/14

$359

Fri 10/314:12 pmPTY - SFO

2 stops22h 48mMultiple Airlines

Deal found 10/14

$377

Cheapflights Fare Finder

Use the filters below to find and compare flights from Panama City to San Francisco that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Panama CitySan Francisco

PTY - SFO

PTYSFO

Panama City Tocumen Intl

Thu 11/13

3:50 pm-11:20 pm

1 stop10h 30m

San Francisco

Tue 11/18

1:20 pm-10:30 am

1 stop18h 10m

$566

Panama CitySan Francisco

PTY - SFO

PTYSFO

Panama City Tocumen Intl

Fri 10/31

2:55 am-12:20 am

2 stops23h 25m

San Francisco

Sat 11/29

1:35 am-6:55 pm

1 stop14h 20m

$589

Panama CitySan Francisco

PTY - SFO

PTYSFO

Panama City Tocumen Intl

Thu 11/6

9:45 am-9:50 pm

2 stops15h 05m

San Francisco

Fri 11/7

11:10 pm-10:30 am

1 stop8h 20m

$596

Panama CitySan Francisco

PTY - SFO

PTYSFO

Panama City Tocumen Intl

Sun 12/7

6:27 pm-11:17 pm

Nonstop7h 50m

San Francisco

Mon 12/29

12:36 am-10:46 am

Nonstop7h 10m

$649

Panama CitySan Francisco

PTY - SFO

PTYSFO

Panama City Tocumen Intl

Sun 12/14

3:46 pm-12:20 am

1 stop11h 34m

San Francisco

Fri 1/2

6:00 am-8:00 pm

1 stop11h 00m

$655

Panama CitySan Francisco

PTY - SFO

PTYSFO

Panama City Tocumen Intl

Sun 12/14

3:35 pm-8:29 pm

Nonstop7h 54m

San Francisco

Thu 1/8

7:10 pm-2:45 pm

1 stop16h 35m

$664

Panama CitySan Francisco

PTY - SFO

PTYSFO

Panama City Tocumen Intl

Fri 12/12

3:35 pm-8:29 pm

Nonstop7h 54m

San Francisco

Sat 1/3

12:25 am-2:45 pm

1 stop11h 20m

$664

Panama CitySan Francisco

PTY - SFO

PTYSFO

Panama City Tocumen Intl

Sun 12/14

3:35 pm-8:29 pm

Nonstop7h 54m

San Francisco

Sat 1/3

12:25 am-2:45 pm

1 stop11h 20m

$664

Panama CitySan Francisco

PTY - SFO

PTYSFO

Panama City Tocumen Intl

Sun 12/7

3:35 pm-8:29 pm

Nonstop7h 54m

San Francisco

Tue 12/30

8:45 am-6:49 pm

Nonstop7h 04m

$664

Panama CitySan Francisco

PTY - SFO

PTYSFO

Panama City Tocumen Intl

Thu 12/11

3:35 pm-8:29 pm

Nonstop7h 54m

San Francisco

Sat 1/3

12:25 am-2:45 pm

1 stop11h 20m

$664

Flights are sorted by cheapest round-trip flights first.

Deals found on 10/14

Showing 1-10 of 19 results

Compare providers for flights from Panama City to San Francisco

Use the table below to compare price accuracy, trust ratings, and cancellation policies for each provider offering flight deals from Panama City to San Francisco in October.

Provider	Price Accuracy	Trust Score*
Expedia	Price Accuracy2 stars	Trust Score*3 stars
FlightHub	Price Accuracy3 stars	Trust Score*3 stars
eDreams	Price Accuracy3 stars	Trust Score*3 stars
AranGrant	Price Accuracy3 stars	Trust Score*3 stars

*The Trust Score is based on feedback from users after their booking experience. It measures overall satisfaction, helping us identify issues like hidden fees, problems during the ticketing process, and the quality of customer service. This score is our best indicator of the provider's quality and reliability.

Most accurate provider: When it comes to deals on Panama City-San Francisco flights, users find the pricing of FlightHub to be most consistent on Cheapflights vs. FlightHub Users can find the same prices on Panama City-San Francisco flight deals on Cheapflights vs. FlightHub >95% of the time. Price accuracy is based on data collected from Panama City-San Francisco flight searches over the past month and is updated monthly.
Most trusted provider: When it comes to deals on Panama City-San Francisco flights, Cheapflights users trust FlightHub the most. FlightHub has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for Panama City-San Francisco flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.

Best time to book a flight from Panama City to San Francisco

Have a flexible travel schedule? Discover the best time to fly to San Francisco from Panama City with our price prediction graph.

Estimated round-trip price

Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Panama City to San Francisco

Prices

Airlines

How far ahead should I book a flight from Panama City to San Francisco?

The price you pay for your flight from Panama City to San Francisco may vary depending on when you book. For the best chance of a lower fare, look to book 64 days in advance of your trip. Fares are likely to increase a fortnight or so before your departure date.

What is the cheapest month to book a flight from Panama City to San Francisco?

Currently, April is the cheapest month in which you can book a flight from Panama City to San Francisco (average of $176). Flying from Panama City to San Francisco in September is currently the most expensive (average of $482). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from PTY to SFO?

Unlike in the afternoon, when flights are generally more expensive, you can save up to 43% on flights from Panama City to San Francisco by exploring options for tickets in the evening.

The best insider tips for Panama City to San Francisco flights

Cheapflights partnered with top experts to bring you the best recommendations for your Panama City to San Francisco trip

Airports

PTY

For US-bound flights, expect two security checks at PTY, with the second at the gate. Allow extra time for this process.

SFO

Use BART for affordable travel from SFO to downtown San Francisco. The trip takes about 40 minutes and starts from the Garage G/Bart station.

Our travel experts

Taryn White

Expert on PTY

Harriet Baskas

Expert on SFO

Reviews of airlines servicing San Francisco

Read through reviews of airlines operating flights from Panama City to San Francisco, such as Copa Airlines, United Airlines, and Avianca. You can also see how each airline stacks up in terms of entertainment options, comfort, food, crew/service, and boarding process.

Copa Airlines

7.6

Good

1,551 reviews

Reviews

1 / 20

4.0

Okay

Juan Pablo,Sep 2025

PTY - VVI

not a good expirience, the plane was packed, the seats wear very unconftrable, coudent conect with the entratainmente service on the plane, the onboarding was in charge of a very angry lady i really had a unplesent trip

Copa Airlines

7.6

Good

1,551 reviews

Copa Airlines

7.6

Good

1,551 reviews

Reviews

1 / 20

4.0

Okay

Juan Pablo,Sep 2025

PTY - VVI

United Airlines

7.4

Good

8,982 reviews

Copa Airlines

7.6

Good

1,551 reviews

Reviews

1 / 20

4.0

Okay

Juan Pablo,Sep 2025

PTY - VVI

Avianca

6.6

Okay

2,452 reviews

Copa Airlines

7.6

Good

1,551 reviews

Reviews

1 / 20

4.0

Okay

Juan Pablo,Sep 2025

PTY - VVI

Related info for your journey

What airports do I use to fly from Panama City to San Francisco?
If you book a flight from Panama City to San Francisco, you will be flying from Tocumen Intl to San Francisco. Flights to San Francisco (SFO) from Panama City Tocumen Intl (PTY) take 7h 35m for a nonstop flight. There are 4 flights from Tocumen Intl to San Francisco per day from 3 airlines.
How popular is this Panama City to San Francisco flight route?
The Panama City Tocumen Intl to San Francisco flight path was viewed by 1 users in the past month. Keep an eye out for changes in search interest prior to high and low season.
How long is the flight from Panama City to San Francisco?
There are many flights that can get you from Panama City to San Francisco in 7h 50m. Fly via Avianca, Copa Airlines, or Delta to get the fastest option. The distance between Panama City and San Francisco is about 3318 mi. Both multi-stop and nonstop flights can be found to your destination and back.
What are the cheapest airlines flying from Panama City to San Francisco round-trip?
Cheapflights users have booked flights from Panama City to San Francisco round-trip from $465. Other airlines that can offer you cheap pricing are United Airlines, from $506, and Copa Airlines, from $506. Avianca is priced at 25% lower than the current average price of a flight leaving 3 months from now.
What are the cheapest flights from Panama City to San Francisco?
The cheapest flight price from Panama City to San Francisco is $330. On average you can expect to pay $818. The most popular route, (Panama City Tocumen Intl - San Francisco), can usually be booked for $579.
Can I find deals for flights from Panama City to San Francisco that include hotel bookings?
Yes. In addition to deals on Panama City to San Francisco flights, Cheapflights offers vacation packages that include both flights and hotel.
How can I find direct flights from Panama City to San Francisco?
After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Panama City to San Francisco.
Can I find deals for business class flights from Panama City to San Francisco?
Yes. Cheapflights offers flight deals from Panama City to San Francisco by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.
What is the cheapest month to book a flight from Panama City to San Francisco?
Currently, April is the cheapest month in which you can book a flight from Panama City to San Francisco (average of $176). Flying from Panama City to San Francisco in September is currently the most expensive (average of $482). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Roseville

Santa Cruz

Livermore

South San Francisco

Turlock

Antioch

Watsonville

Santa Clara

Manteca

Sunnyvale

Vacaville

Vallejo

Hollister

Foster City

Union City

Fairfield

Burlingame

Redwood City

Lodi

San Mateo

Browse thousands of different options on Cheapflights for your next trip

Top 3 airlines flying from Panama City to San Francisco

Airline	Cheapest	Average	Flexibility	On-time
Avianca	Cheapest$465	Average$535	FlexibilityNo cancel fee	On-time71%
United Airlines	Cheapest$506	Average$640	FlexibilityNo cancel fee	On-time69%
Copa Airlines	Cheapest$506	Average$633	FlexibilityNo cancel fee	On-time70%

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$264+ Cheap flights from Panama City (PTY) to San Francisco (SFO)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 10/23. Fares are subject to change and may not be available on all flights or dates of travel.

Find cheap flights from Panama City to San Francisco with Cheapflights

1. Tell us where you want to go

2. Select your favorite providers

3. Compare prices and book

Cheapflights Tip: The best prices from Panama City Tocumen Intl to San Francisco are usually found in August or September, booked 67 days in advance, depart on a Monday or Saturday and return on a Tuesday

Cheap flight deals from Panama City to San Francisco

Most accurate provider

Most trusted provider

Round-trip from

One-way from

Popular in

Cheapest in

Average price

Good round-trip deal

Good one-way deal

Find flight deals from Panama City to San Francisco

Cheapest flights from Panama City to San FranciscoExplore the most affordable flight options available from Panama City to San Francisco. Find the lowest fares from popular airlines and budget airlines, with prices last updated on October 16, 2025.

Explore the most affordable flight options available from Panama City to San Francisco. Find the lowest fares from popular airlines and budget airlines, with prices last updated on October 16, 2025.

Cheapflights Fare Finder

Use the filters below to find and compare flights from Panama City to San Francisco that are best for you.

Compare providers for flights from Panama City to San Francisco

Provider information is updated monthly. Please note that these providers often have deals for this flight, but the availability may vary on a day-by-day basis on Cheapflights.

Use the table below to compare price accuracy, trust ratings, and cancellation policies for each provider offering flight deals from Panama City to San Francisco in October.

Best time to book a flight from Panama City to San Francisco

Have a flexible travel schedule? Discover the best time to fly to San Francisco from Panama City with our price prediction graph.

Cheapflights Insights

Everything you need to know about your flight from Panama City to San Francisco

How far ahead should I book a flight from Panama City to San Francisco?

What is the cheapest month to book a flight from Panama City to San Francisco?

What is the cheapest time of day to fly from PTY to SFO?

Weekly flight availability from Panama City to San Francisco

The best insider tips for Panama City to San Francisco flights

Cheapflights partnered with top experts to bring you the best recommendations for your Panama City to San Francisco trip

Airports

PTY

SFO

Our travel experts

Reviews of airlines servicing San Francisco

Read through reviews of airlines operating flights from Panama City to San Francisco, such as Copa Airlines, United Airlines, and Avianca. You can also see how each airline stacks up in terms of entertainment options, comfort, food, crew/service, and boarding process.

Related info for your journey

Find useful and relevant information for your journey from Panama City to San Francisco. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

What airports do I use to fly from Panama City to San Francisco?

How popular is this Panama City to San Francisco flight route?

How long is the flight from Panama City to San Francisco?

What are the cheapest airlines flying from Panama City to San Francisco round-trip?

What are the cheapest flights from Panama City to San Francisco?

Can I find deals for flights from Panama City to San Francisco that include hotel bookings?

How can I find direct flights from Panama City to San Francisco?

Can I find deals for business class flights from Panama City to San Francisco?

What is the cheapest month to book a flight from Panama City to San Francisco?

Traveling to a place near San Francisco?

Browse thousands of different options on Cheapflights for your next trip

Toggle through the tabs below to find thousands of options on Cheapflights for your next trip.

Alternative routes for Panama City to San Francisco

See prices for flight routes from nearby airports that may be better suited for you.

Top 3 airlines flying from Panama City to San Francisco

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Travel Smart

Cheapest flights from Panama City to San Francisco
Explore the most affordable flight options available from Panama City to San Francisco. Find the lowest fares from popular airlines and budget airlines, with prices last updated on October 16, 2025.