HomeSearch by dateVacation packagesHotelsFlight dealsCar rentalTravel tips & news
San Francisco

$285+ Cheap flights from Panama City (PTY) to San Francisco (SFO)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 1/17. Fares are subject to change and may not be available on all flights or dates of travel.
PTY — SFO
Oct 16 — Oct 231
Thu 10/16
Thu 10/23
1 adult, Economy
We work with more than 300 partners to bring you better travel deals

Find cheap flights from Panama City to San Francisco with Cheapflights

1. Tell us where you want to go

Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”

2. Select your favorite providers

We find the providers serving your travel needs. Choose up to four travel providers to compare side-by-side for flights, hotels, or car rentals.

3. Compare prices and book

Review each provider’s pricing and select the best option for you! Book through your favorite provider’s website for a seamless experience.

Cheapflights Tip: The best prices from Panama City Tocumen Intl to San Francisco are usually found in August or July, booked 67 days in advance, depart on a Monday or Saturday and return on a Tuesday

Cheap flight deals from Panama City to San Francisco

Discover tips and strategies to find the most affordable flight options for your journey from Panama City (PTY) to San Francisco (SFO). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated September 16, 2025.

Round-trip from

$496
(Mytrip)

One-way from

$285
(Mytrip)

Popular in

October

Cheapest in

August

Average price

$625

Good round-trip deal

$582 or less

Good one-way deal

$423 or less
From Panama City Tocumen Intl to San Francisco
Search Deals
One-way flight from Panama City Tocumen Intl to San Francisco
Search Deals
Highest demand for flights based on searches. 4% potential increase in price ($30 potential increase over avg. RT price).
Search Deals
Cheapest flight prices on average. 1% potential price decrease ($9 potential savings vs. average RT price).
Search Deals
Average for round-trip flights in September 2025
Search Deals
Price to beat on a round-trip flight from Panama City Tocumen Intl to San Francisco.
Search Deals
Price to beat on a one-way flight from Panama City Tocumen Intl to San Francisco.
Search Deals

Find flight deals from Panama City to San Francisco

Cheapest flights from Panama City to San Francisco
Explore the most affordable flight options available from Panama City to San Francisco. Find the lowest fares from popular airlines and budget airlines, with prices last updated on September 16, 2025.

This Gotogate deal was found by Cheapflights users on 9/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Gotogate is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 11/113:35 pmPTY - SFO
1 stop10h 45mAvianca
Tue 11/181:20 pmSFO - PTY
2 stops16h 30mAvianca
Deal found 9/14$496
This Trip.com deal was found by Cheapflights users on 9/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Trip.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/293:35 pmPTY - SFO
1 stop9h 15mAvianca
Tue 11/41:35 amSFO - PTY
1 stop14h 20mAvianca
Deal found 9/13$498
This Avianca deal was found by Cheapflights users on 9/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Avianca is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/119:55 amPTY - SFO
2 stops14h 50mAvianca
Tue 10/1412:05 amSFO - PTY
2 stops19h 05mAvianca
Deal found 9/14$499
This Priceline deal was found by Cheapflights users on 9/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Priceline is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 9/303:20 amPTY - SFO
2 stops21h 25mAvianca
Mon 10/1312:05 amSFO - PTY
1 stop8h 20mAvianca
Deal found 9/14$502
This Booking.com deal was found by Cheapflights users on 9/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Booking.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/302:55 amPTY - SFO
2 stops21h 55mAvianca
Mon 11/311:10 pmSFO - PTY
2 stops22h 50mAvianca
Deal found 9/14$506
This Avianca deal was found by Cheapflights users on 9/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Avianca is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/133:35 pmPTY - SFO
1 stop10h 45mAvianca
Mon 11/171:20 pmSFO - PTY
1 stop18h 00mAvianca
Deal found 9/15$509
This Avianca deal was found by Cheapflights users on 9/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Avianca is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/119:55 amPTY - SFO
2 stops16h 00mAvianca
Sat 10/182:20 pmSFO - PTY
2 stops17h 50mAvianca
Deal found 9/15$510
This Priceline deal was found by Cheapflights users on 9/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Priceline is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 9/263:25 amPTY - SFO
2 stops21h 20mAvianca
Sun 10/512:05 amSFO - PTY
2 stops22h 40mAvianca
Deal found 9/15$512
This Cheapflightsfares deal was found by Cheapflights users on 9/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Cheapflightsfares is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 9/293:25 amPTY - SFO
2 stops21h 20mAvianca
Wed 10/82:20 pmSFO - PTY
2 stops16h 35mAvianca
Deal found 9/14$514
This Booking.com deal was found by Cheapflights users on 9/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Booking.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 9/213:20 amPTY - SFO
2 stops21h 25mAvianca
Sat 9/2712:05 amSFO - PTY
1 stop8h 20mAvianca
Deal found 9/14$516

Cheapflights Fare Finder

 
Customize your flight search to find flights from Panama City to San Francisco that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated September 16, 2025.
Use the filters below to find and compare flights from Panama City to San Francisco that are best for you.

Fly from

Panama City

Fly to

San Francisco

Route

Depart

Return

Price

Panama CitySan Francisco

PTY - SFO

PTYSFO

Panama City Tocumen Intl

Sat 10/11

9:55 am-11:55 pm

2 stops16h 00m

San Francisco

Wed 10/15

2:20 pm-8:55 am

2 stops16h 35m

$499

Panama CitySan Francisco

PTY - SFO

PTYSFO

Panama City Tocumen Intl

Thu 11/13

9:45 am-11:20 pm

2 stops16h 35m

San Francisco

Sun 11/16

1:20 pm-10:20 am

1 stop18h 00m

$499

Panama CitySan Francisco

PTY - SFO

PTYSFO

Panama City Tocumen Intl

Mon 9/29

3:25 am-10:45 pm

2 stops21h 20m

San Francisco

Tue 10/7

12:05 am-9:10 pm

2 stops19h 05m

$514

Panama CitySan Francisco

PTY - SFO

PTYSFO

Panama City Tocumen Intl

Fri 9/26

3:25 am-10:45 pm

2 stops21h 20m

San Francisco

Mon 10/6

2:20 pm-8:55 am

2 stops16h 35m

$524

Panama CitySan Francisco

PTY - SFO

PTYSFO

Panama City Tocumen Intl

Sat 11/1

9:45 am-10:50 pm

2 stops15h 05m

San Francisco

Sat 11/29

1:35 am-6:55 pm

1 stop14h 20m

$575

Panama CitySan Francisco

PTY - SFO

PTYSFO

Panama City Tocumen Intl

Thu 11/27

6:27 pm-11:17 pm

Nonstop7h 50m

San Francisco

Wed 12/3

12:36 am-10:46 am

Nonstop7h 10m

$649

Panama CitySan Francisco

PTY - SFO

PTYSFO

Panama City Tocumen Intl

Thu 11/13

6:27 pm-11:17 pm

Nonstop7h 50m

San Francisco

Sat 11/15

12:36 am-10:46 am

Nonstop7h 10m

$649

Panama CitySan Francisco

PTY - SFO

PTYSFO

Panama City Tocumen Intl

Mon 1/19

3:35 pm-8:29 pm

Nonstop7h 54m

San Francisco

Fri 1/30

8:45 am-6:49 pm

Nonstop7h 04m

$664

Panama CitySan Francisco

PTY - SFO

PTYSFO

Panama City Tocumen Intl

Thu 11/20

3:35 pm-8:29 pm

Nonstop7h 54m

San Francisco

Thu 11/27

8:45 am-6:49 pm

Nonstop7h 04m

$664

Panama CitySan Francisco

PTY - SFO

PTYSFO

Panama City Tocumen Intl

Sat 12/6

3:35 pm-8:29 pm

Nonstop7h 54m

San Francisco

Fri 12/26

7:11 pm-5:07 pm

1 stop18h 56m

$664

Flights are sorted by cheapest round-trip flights first.

Deals found on 9/15

Showing 1-10 of 16 results
1
2

The best insider tips for Panama City to San Francisco flights

Snippets provided in this section are AI-generated based on a summarization of Cheapflights-commissioned articles. The articles are presented as-is, for general informational purposes only, and may not be up-to-date. The opinions contained in the articles are original to the author and reflect their authentic experience, which may vary significantly from the experience of others.
Cheapflights partnered with top experts to bring you the best recommendations for your Panama City to San Francisco trip
Airports
PTY

For US-bound flights, expect two security checks at PTY, with the second at the gate. Allow extra time for this process.

Read more about PTYby Taryn White
SFO

Use BART for affordable travel from SFO to downtown San Francisco. The trip takes about 40 minutes and starts from the Garage G/Bart station.

Read more about SFOby Harriet Baskas
Our travel experts
Taryn White

Taryn White

Expert on PTY

Taryn White

Taryn White

Taryn White is a freelance travel writer, digital creator, and travel advisor who has visited nearly 100 countries and all 50 states. She’s familiar with many airports and enjoys beach hopping, boutique hotels, spa experiences, and exploring local culture. Her work has appeared in Travel + Leisure, Condé Nast Traveler, National Geographic, Smithsonian Magazine, AFAR, and more.

Read more
Harriet Baskas

Harriet Baskas

Expert on SFO

Harriet Baskas

Harriet Baskas

Harriet is an award-winning journalist who is happiest in an airport or an unusual museum. Her stories about airports, air travel, and the business of travel have appeared on NBC News, CNBC, USA TODAY, The Points Guy and other outlets. She is the creator of the StuckatTheAirport.com blog and the author of nine books. When not out on the road or exploring the latest airport amenities, she’s home in Seattle getting ready for the next adventure.

Read more

Best time to book a flight from Panama City to San Francisco

Have a flexible travel schedule? Discover the best time to fly to San Francisco from Panama City with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Panama City to San Francisco

How far ahead should I book a flight from Panama City to San Francisco?

Use this chart to determine the optimal time to book a round-trip flight from Panama City to San Francisco. Price data was last updated on September 12, 2025.

The price you pay for your flight from Panama City to San Francisco may vary depending on when you book. For the best chance of a lower fare, look to book 67 days in advance of your trip. Fares are likely to increase a fortnight or so before your departure date.

What is the cheapest month to book a flight from Panama City to San Francisco?

Currently, January is the cheapest month in which you can book a flight from Panama City to San Francisco (average of $276). Flying from Panama City to San Francisco in June is currently the most expensive (average of $357). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from PTY to SFO?

Find hourly flight availability from Panama City to San Francisco. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated September 16, 2025.

Unlike in the afternoon, when flights are generally more expensive, you can save up to 45% on flights from Panama City to San Francisco by exploring options for tickets in the evening.

How much does it cost to fly round-trip from Panama City to San Francisco?

Reviews of airlines servicing San Francisco

Get insights into the airlines that provide service to San Francisco. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to San Francisco. Reviews last updated September 16, 2025.
Read through reviews of airlines operating flights from Panama City to San Francisco, such as Copa Airlines, United Airlines, and Avianca. You can also see how each airline stacks up in terms of entertainment options, comfort, food, crew/service, and boarding process.
Copa Airlines
7.6
Good
1,531 reviews

Entertainment

6.8

Comfort

7.4

Food

6.8

Overall

7.6

Boarding

7.8

Crew

8.1

Reviews

1 / 20
4.0
Okay

Juan Pablo,Sep 2025

PTY - VVI

not a good expirience, the plane was packed, the seats wear very unconftrable, coudent conect with the entratainmente service on the plane, the onboarding was in charge of a very angry lady i really had a unplesent trip
Copa Airlines
7.6
Good
1,531 reviews
Copa Airlines
7.6
Good
1,531 reviews

Entertainment

6.8

Comfort

7.4

Food

6.8

Overall

7.6

Boarding

7.8

Crew

8.1

Reviews

1 / 20
4.0
Okay

Juan Pablo,Sep 2025

PTY - VVI

not a good expirience, the plane was packed, the seats wear very unconftrable, coudent conect with the entratainmente service on the plane, the onboarding was in charge of a very angry lady i really had a unplesent trip
United Airlines
7.4
Good
8,924 reviews
Copa Airlines
7.6
Good
1,531 reviews

Entertainment

6.8

Comfort

7.4

Food

6.8

Overall

7.6

Boarding

7.8

Crew

8.1

Reviews

1 / 20
4.0
Okay

Juan Pablo,Sep 2025

PTY - VVI

not a good expirience, the plane was packed, the seats wear very unconftrable, coudent conect with the entratainmente service on the plane, the onboarding was in charge of a very angry lady i really had a unplesent trip
Avianca
6.7
Okay
2,435 reviews
Copa Airlines
7.6
Good
1,531 reviews

Entertainment

6.8

Comfort

7.4

Food

6.8

Overall

7.6

Boarding

7.8

Crew

8.1

Reviews

1 / 20
4.0
Okay

Juan Pablo,Sep 2025

PTY - VVI

not a good expirience, the plane was packed, the seats wear very unconftrable, coudent conect with the entratainmente service on the plane, the onboarding was in charge of a very angry lady i really had a unplesent trip

Related info for your journey

Find useful and relevant information for your journey from Panama City to San Francisco. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airports do I use to fly from Panama City to San Francisco?

    If you book a flight from Panama City to San Francisco, you will be flying from Tocumen Intl to San Francisco. Flights to San Francisco (SFO) from Panama City Tocumen Intl (PTY) take 7h 35m for a nonstop flight. There are 3 flights from Tocumen Intl to San Francisco per day from 3 airlines.

  • How popular is this Panama City to San Francisco flight route?

    The Panama City Tocumen Intl to San Francisco flight path was viewed by 1 users in the past month. Keep an eye out for changes in search interest prior to high and low season.

  • How long is the flight from Panama City to San Francisco?

    There are many flights that can get you from Panama City to San Francisco in 16h 35m. Fly via Avianca to get the fastest option. The distance between Panama City and San Francisco is about 3318 mi.

  • What are the cheapest airlines flying from Panama City to San Francisco round-trip?

    Cheapflights users have booked flights from Panama City to San Francisco round-trip from $366. Other airlines that can offer you cheap pricing are Avianca, from $474, and United Airlines, from $506. Copa Airlines is priced at 42% lower than the current average price of a flight leaving 3 months from now.

  • What are the cheapest flights from Panama City to San Francisco?

    The cheapest flight price from Panama City to San Francisco is $348. On average you can expect to pay $892. The most popular route, (Panama City Tocumen Intl - San Francisco), can usually be booked for $499.

  • Can I find deals for flights from Panama City to San Francisco that include hotel bookings?

    Yes. In addition to deals on Panama City to San Francisco flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Panama City to San Francisco?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Panama City to San Francisco.

  • Can I find deals for business class flights from Panama City to San Francisco?

    Yes. Cheapflights offers flight deals from Panama City to San Francisco by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Panama City to San Francisco?

    Currently, January is the cheapest month in which you can book a flight from Panama City to San Francisco (average of $276). Flying from Panama City to San Francisco in June is currently the most expensive (average of $357). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Traveling to a place near San Francisco?

Book flights to San Francisco if you plan to visit one of these locations
Roseville
Santa Cruz
Livermore
South San Francisco
Turlock
Antioch
Watsonville
Santa Clara
Manteca
Sunnyvale
Hollister
Vacaville
Foster City
Union City
Vallejo
Burlingame
Redwood City
San Mateo
San Leandro
Lathrop

Browse thousands of different options on Cheapflights for your next trip

Toggle through the tabs below to find thousands of options on Cheapflights for your next trip.

Top 3 airlines flying from Panama City to San Francisco

Discover the top 3 airlines that operate flights from Panama City to San Francisco. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated September 16, 2025.
AirlineCheapestAverageFlexibilityOn-time
Copa AirlinesCheapest$366Average$631FlexibilityNo cancel feeOn-time70%
AviancaCheapest$474Average$584FlexibilityNo cancel feeOn-time71%
United AirlinesCheapest$506Average$633FlexibilityNo cancel feeOn-time69%

100% Free

Cheapflights is completely free to use, so you can start saving the moment you arrive.

Book with Flexibility

Our users can plan ahead with confidence and find flights with no change fees

Travel Smart

Millions of people come to us for their flight needs every year. We help make travel planning easy by providing useful insights and data-driven graphs that can inform your decisions.