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$96+ Cheap flights from Knoxville to San Francisco (TYS - SFO)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 12/15. Fares are subject to change and may not be available on all flights or dates of travel.
TYS — SFO
Nov 15 — Nov 221
Sat 11/15
Sat 11/22
1 adult, Economy
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1. Tell us where you want to go

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Cheapflights Tip: The best prices from Knoxville McGhee Tyson to San Francisco are usually found in January or July, booked 65 days in advance, depart on a Tuesday or Wednesday and return on a Tuesday

Find flight deals from Knoxville to San Francisco

Cheapest flights from Knoxville to San Francisco
Explore the most affordable flight options available from Knoxville to San Francisco. Find the lowest fares from popular airlines and budget airlines, with prices last updated on October 16, 2025.

This Kiwi.com deal was found by Cheapflights users on 10/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/307:00 amTYS - SFO
2 stops37h 43mMultiple Airlines
Sat 11/86:34 amSFO - TYS
1 stop28h 10mMultiple Airlines
Deal found 10/16$222
This Kiwi.com deal was found by Cheapflights users on 10/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 10/278:17 pmTYS - SFO
1 stop29h 10mMultiple Airlines
Sat 11/86:34 amSFO - TYS
1 stop28h 10mMultiple Airlines
Deal found 10/16$228
This Kiwi.com deal was found by Cheapflights users on 10/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/307:00 amTYS - SFO
2 stops37h 43mMultiple Airlines
Wed 11/58:55 pmSFO - TYS
1 stop23h 03mMultiple Airlines
Deal found 10/16$240
This Kiwi.com deal was found by Cheapflights users on 10/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/3112:45 pmTYS - SFO
2 stops31h 58mMultiple Airlines
Sat 11/86:34 amSFO - TYS
1 stop28h 10mMultiple Airlines
Deal found 10/16$246
This Kiwi.com deal was found by Cheapflights users on 10/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/307:17 pmTYS - SFO
1 stop7h 57mFrontier
Sat 11/87:30 pmSFO - TYS
2 stops19h 52mFrontier
Deal found 10/15$257
This Kiwi.com deal was found by Cheapflights users on 10/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 11/27:00 amTYS - SFO
1 stop20h 14mMultiple Airlines
Sat 11/86:34 amSFO - TYS
1 stop28h 10mMultiple Airlines
Deal found 10/15$260
This Kiwi.com deal was found by Cheapflights users on 10/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 10/278:17 pmTYS - SFO
1 stop29h 10mFrontier
Sun 11/96:34 amSFO - TYS
1 stop8h 48mFrontier
Deal found 10/16$276
This Kiwi.com deal was found by Cheapflights users on 10/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 10/278:17 pmTYS - SFO
2 stops24h 26mMultiple Airlines
Wed 11/58:55 pmSFO - TYS
1 stop23h 03mMultiple Airlines
Deal found 10/16$279
This Frontier deal was found by Cheapflights users on 10/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Frontier is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/307:17 pmTYS - SFO
1 stop7h 57mFrontier
Sun 11/96:34 amSFO - TYS
1 stop8h 48mFrontier
Deal found 10/15$281

Cheap flight deals from Knoxville to San Francisco

Discover tips and strategies to find the most affordable flight options for your journey from Knoxville (TYS) to San Francisco (SFO). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated October 16, 2025.

Most accurate provider

FlightHub
3 stars

Most trusted provider

FlightHub
3 stars

Round-trip from

$210
(Frontier)

One-way from

$96
(Priceline)

Popular in

March

Cheapest in

January

Average price

$453
Provider with most accurate pricing for Knoxville McGhee Tyson-San Francisco flight deals.
Search Deals
Provider most trusted by Cheapflights users for Knoxville McGhee Tyson-San Francisco flights.
Search Deals
From Knoxville McGhee Tyson to San Francisco
Search Deals
One-way flight from Knoxville McGhee Tyson to San Francisco
Search Deals
Highest demand for flights based on searches. 3% potential increase in price ($14 potential increase over avg. RT price).
Search Deals
Cheapest flight prices on average. 2% potential price decrease ($10 potential savings vs. average RT price).
Search Deals
Average for round-trip flights in October 2025
Search Deals

Cheapflights Fare Finder

 
Customize your flight search to find flights from Knoxville to San Francisco that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated October 16, 2025.
Use the filters below to find and compare flights from Knoxville to San Francisco that are best for you.

Fly from

Knoxville

Fly to

San Francisco

Route

Depart

Return

Price

KnoxvilleSan Francisco

TYS - SFO

TYSSFO

Knoxville McGhee Tyson

Thu 10/30

7:00 am-12:14 am

1 stop20h 14m

San Francisco

Sun 11/2

5:34 am-5:07 pm

1 stop8h 33m

$312

KnoxvilleSan Francisco

TYS - SFO

TYSSFO

Knoxville McGhee Tyson

Thu 10/30

7:17 pm-5:43 pm

2 stops25h 26m

San Francisco

Thu 11/6

6:34 am-6:22 pm

1 stop8h 48m

$316

KnoxvilleSan Francisco

TYS - SFO

TYSSFO

Knoxville McGhee Tyson

Tue 11/11

7:20 pm-1:15 am

1 stop8h 55m

San Francisco

Sat 11/15

5:00 am-2:42 pm

1 stop6h 42m

$329

KnoxvilleSan Francisco

TYS - SFO

TYSSFO

Knoxville McGhee Tyson

Mon 12/15

7:05 am-12:09 pm

1 stop8h 04m

San Francisco

Sun 12/28

11:06 pm-10:56 am

1 stop8h 50m

$329

KnoxvilleSan Francisco

TYS - SFO

TYSSFO

Knoxville McGhee Tyson

Fri 10/31

3:56 pm-9:06 pm

1 stop8h 10m

San Francisco

Mon 11/10

9:30 pm-9:37 am

1 stop9h 07m

$351

KnoxvilleSan Francisco

TYS - SFO

TYSSFO

Knoxville McGhee Tyson

Fri 10/31

7:11 am-1:33 pm

1 stop9h 22m

San Francisco

Sun 11/9

10:45 pm-11:45 am

1 stop10h 00m

$351

KnoxvilleSan Francisco

TYS - SFO

TYSSFO

Knoxville McGhee Tyson

Sat 11/1

3:43 pm-10:30 pm

1 stop9h 47m

San Francisco

Mon 11/10

10:30 pm-9:37 am

1 stop8h 07m

$359

KnoxvilleSan Francisco

TYS - SFO

TYSSFO

Knoxville McGhee Tyson

Wed 10/29

5:44 am-9:58 am

1 stop7h 14m

San Francisco

Sat 11/8

10:57 pm-11:45 am

1 stop9h 48m

$359

KnoxvilleSan Francisco

TYS - SFO

TYSSFO

Knoxville McGhee Tyson

Sat 11/1

7:45 am-11:46 am

1 stop7h 01m

San Francisco

Sun 11/9

10:45 pm-11:45 am

1 stop10h 00m

$359

KnoxvilleSan Francisco

TYS - SFO

TYSSFO

Knoxville McGhee Tyson

Tue 11/4

5:16 pm-9:06 pm

1 stop6h 50m

San Francisco

Sun 11/9

10:45 pm-11:45 am

1 stop10h 00m

$359

Flights are sorted by cheapest round-trip flights first.

Deals found on 10/15

Showing 1-10 of 21 results
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Compare providers for flights from Knoxville to San Francisco

Provider information is updated monthly. Please note that these providers often have deals for this flight, but the availability may vary on a day-by-day basis on Cheapflights.
Use the table below to compare price accuracy, trust ratings, and cancellation policies for each provider offering flight deals from Knoxville to San Francisco in October.
ProviderPrice AccuracyTrust Score*
ExpediaPrice Accuracy2 starsTrust Score*3 stars
FlightHubPrice Accuracy3 starsTrust Score*3 stars
eDreamsPrice Accuracy3 starsTrust Score*3 stars

*The Trust Score is based on feedback from users after their booking experience. It measures overall satisfaction, helping us identify issues like hidden fees, problems during the ticketing process, and the quality of customer service. This score is our best indicator of the provider's quality and reliability.

  • Most accurate provider: When it comes to deals on Knoxville-San Francisco flights, users find the pricing of FlightHub to be most consistent on Cheapflights vs. FlightHub Users can find the same prices on Knoxville-San Francisco flight deals on Cheapflights vs. FlightHub >95% of the time. Price accuracy is based on data collected from Knoxville-San Francisco flight searches over the past month and is updated monthly.
  • Most trusted provider: When it comes to deals on Knoxville-San Francisco flights, Cheapflights users trust FlightHub the most. FlightHub has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for Knoxville-San Francisco flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.

Best time to book a flight from Knoxville to San Francisco

Have a flexible travel schedule? Discover the best time to fly to San Francisco from Knoxville with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Knoxville to San Francisco

How far ahead should I book a flight from Knoxville to San Francisco?

Use this chart to determine the optimal time to book a round-trip flight from Knoxville to San Francisco. Price data was last updated on October 10, 2025.

The best time to book flights from Knoxville to San Francisco is 65 days before your desired departure date. The cost of your flight will likely increase significantly if you book two weeks in advance of your flight.

What is the cheapest month to book a flight from Knoxville to San Francisco?

Currently, January is the cheapest month in which you can book a flight from Knoxville to San Francisco (average of $168). Flying from Knoxville to San Francisco in December is currently the most expensive (average of $347). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from TYS to SFO?

Find hourly flight availability from Knoxville to San Francisco. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated October 16, 2025.

One of the essential ways to save on airfare from Knoxville to San Francisco is to remain as flexible as possible. Flights that are in the morning tend to be the most expensive. A flight in the evening could potentially save you up to 29% on airfare.

What is the cheapest day to fly from Knoxville to San Francisco?

Use this chart to determine the cheapest time to fly round-trip from Knoxville to San Francisco. Price data was last updated on December 16, 2024.

Travelers seeking maximum savings on their Knoxville to San Francisco flight should consider departing on Saturday evenings when fares are most often at their lowest. Sunday at noon flights should be avoided if possible as fares are typically the most expensive at this time.

Reviews of airlines servicing San Francisco

Get insights into the airlines that provide service to San Francisco. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to San Francisco. Reviews last updated October 16, 2025.
Peruse reviews from past customers who have flown with Delta, United Airlines, and American Airlines from Knoxville to San Francisco to help guide your decision. You can also see how each airline stacks up in terms of entertainment options, comfort, food, crew/service, and boarding process.
Delta
8.0
Very good
7,984 reviews

Food

7.3

Boarding

8.2

Entertainment

7.9

Overall

8.0

Comfort

7.9

Crew

8.5

Reviews

1 / 20
10.0
Excellent

Aaron,Oct 2024

TUS - LAX

Delta has consistently been the best U.S. airline for my travels and this flight was no exception
Delta
8.0
Very good
7,984 reviews
Delta
8.0
Very good
7,984 reviews

Food

7.3

Boarding

8.2

Entertainment

7.9

Overall

8.0

Comfort

7.9

Crew

8.5

Reviews

1 / 20
10.0
Excellent

Aaron,Oct 2024

TUS - LAX

Delta has consistently been the best U.S. airline for my travels and this flight was no exception
United Airlines
7.4
Good
8,982 reviews
Delta
8.0
Very good
7,984 reviews

Food

7.3

Boarding

8.2

Entertainment

7.9

Overall

8.0

Comfort

7.9

Crew

8.5

Reviews

1 / 20
10.0
Excellent

Aaron,Oct 2024

TUS - LAX

Delta has consistently been the best U.S. airline for my travels and this flight was no exception
American Airlines
7.2
Good
11,043 reviews
Delta
8.0
Very good
7,984 reviews

Food

7.3

Boarding

8.2

Entertainment

7.9

Overall

8.0

Comfort

7.9

Crew

8.5

Reviews

1 / 20
10.0
Excellent

Aaron,Oct 2024

TUS - LAX

Delta has consistently been the best U.S. airline for my travels and this flight was no exception
Frontier
5.8
Fair
3,137 reviews
Delta
8.0
Very good
7,984 reviews

Food

7.3

Boarding

8.2

Entertainment

7.9

Overall

8.0

Comfort

7.9

Crew

8.5

Reviews

1 / 20
10.0
Excellent

Aaron,Oct 2024

TUS - LAX

Delta has consistently been the best U.S. airline for my travels and this flight was no exception

Related info for your journey

Find useful and relevant information for your journey from Knoxville to San Francisco. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • How long is the flight from Knoxville to San Francisco?

    Departing from Knoxville to San Francisco will take you 8h 10m. The distance between Knoxville and San Francisco is about 2114 mi. Both multi-stop and nonstop flights can be found to your destination and back.

  • What are the cheapest airlines flying from Knoxville to San Francisco round-trip?

    Flying on Frontier is currently your cheapest option to San Francisco, with prices starting at $157. Additional round-trip tickets that might be worth considering are offered by United Airlines and American Airlines, with the lowest prices starting at $243 and $308, respectively. Frontier is priced at 63% lower than the current average price of a flight leaving 3 months from now.

  • Can I find deals for flights from Knoxville to San Francisco that include hotel bookings?

    Yes. In addition to deals on Knoxville to San Francisco flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Knoxville to San Francisco?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Knoxville to San Francisco.

  • Can I find deals for business class flights from Knoxville to San Francisco?

    Yes. Cheapflights offers flight deals from Knoxville to San Francisco by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Knoxville to San Francisco?

    Currently, January is the cheapest month in which you can book a flight from Knoxville to San Francisco (average of $168). Flying from Knoxville to San Francisco in December is currently the most expensive (average of $347). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Traveling to a place near San Francisco?

Book flights to San Francisco if you plan to visit one of these locations
Roseville
Santa Cruz
Livermore
South San Francisco
Turlock
Antioch
Watsonville
Santa Clara
Manteca
Sunnyvale
Vacaville
Vallejo
Hollister
Foster City
Union City
Fairfield
Burlingame
Redwood City
Lodi
San Mateo

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Top 4 airlines flying from Knoxville to San Francisco

Discover the top 4 airlines that operate flights from Knoxville to San Francisco. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated October 16, 2025.
AirlineCheapestAverageFlexibilityOn-time
FrontierCheapest$157Average$210FlexibilityNo cancel feeOn-time62%
United AirlinesCheapest$243Average$537FlexibilityNo cancel feeOn-time69%
DeltaCheapest$308Average$418FlexibilityNo cancel feeOn-timeN/A
American AirlinesCheapest$308Average$418FlexibilityNo cancel feeOn-time71%

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