$127+ Cheap flights from Knoxville to San Francisco (TYS - SFO)
This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 4/22. Fares are subject to change and may not be available on all flights or dates of travel.
TYS — SFO
Apr 23 — Apr 301
Round-trip
1 adult, Economy
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Cheapest flights from Knoxville to San FranciscoExplore the most affordable flight options available from Knoxville to San Francisco. Find the lowest fares from popular airlines and budget airlines, with prices last updated on March 24, 2026.
Explore the most affordable flight options available from Knoxville to San Francisco. Find the lowest fares from popular airlines and budget airlines, with prices last updated on March 24, 2026.
This CheapOair deal was found by Cheapflights users on 3/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure CheapOair is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 4/164:28 pm
TYS
- SFO
1 stop19h 45m
Frontier
Sun 4/196:00 am
SFO
- TYS
1 stop6h 33m
Frontier
Deal found 3/20![Frontier logo]()
$221
This American Airlines deal was found by Cheapflights users on 3/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 5/57:00 am
TYS
- SFO
1 stop8h 32m
American Airlines
Tue 5/129:08 am
SFO
- TYS
1 stop10h 04m
American Airlines
Deal found 3/24![American Airlines logo]()
$253
This CheapOair deal was found by Cheapflights users on 3/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure CheapOair is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 5/228:32 pm
TYS
- SFO
1 stop14h 29m
Frontier
Mon 5/258:56 am
SFO
- TYS
1 stop7h 37m
Frontier
Deal found 3/24![Frontier logo]()
$261
This United Airlines deal was found by Cheapflights users on 3/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 4/287:05 am
TYS
- SFO
1 stop8h 13m
United Airlines
Sat 5/211:10 am
SFO
- TYS
1 stop8h 13m
United Airlines
Deal found 3/24![United Airlines logo]()
$278
This United Airlines deal was found by Cheapflights users on 3/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 5/27:00 am
TYS
- SFO
1 stop7h 24m
United Airlines
Sat 5/95:30 am
SFO
- TYS
1 stop8h 24m
United Airlines
Deal found 3/24![United Airlines logo]()
$298
This CheapOair deal was found by Cheapflights users on 3/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure CheapOair is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 6/18:32 pm
TYS
- SFO
1 stop18h 10m
Frontier
Tue 6/912:33 pm
SFO
- TYS
1 stop28h 04m
Frontier
Deal found 3/24![Frontier logo]()
$301
This Kiwi.com deal was found by Cheapflights users on 3/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 5/151:15 pm
TYS
- SFO
2 stops36h 49m
Multiple Airlines
Wed 5/2012:52 pm
SFO
- TYS
1 stop22h 07m
Multiple Airlines
Deal found 3/22![Multiple Airlines logo]()
$305
This Southwest deal was found by Cheapflights users on 3/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 5/212:20 pm
TYS
- SFO
2 stops12h 00m
Southwest
Sat 5/910:10 am
SFO
- TYS
1 stop6h 25m
Southwest
Deal found 3/24![Southwest logo]()
$308
This Expedia deal was found by Cheapflights users on 3/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Expedia is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 4/64:20 pm
TYS
- SFO
1 stop11h 08m
Frontier
Fri 4/106:00 am
SFO
- TYS
1 stop6h 28m
Frontier
Deal found 3/21![Frontier logo]()
$310
This CheapOair deal was found by Cheapflights users on 3/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure CheapOair is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 4/34:20 pm
TYS
- SFO
1 stop11h 03m
Frontier
Sun 4/59:00 pm
SFO
- TYS
1 stop15h 28m
Frontier
Deal found 3/23![Frontier logo]()
$316
This Kiwi.com deal was found by Cheapflights users on 3/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 5/78:00 am
TYS
- SFO
1 stop11h 30m
Multiple Airlines
Sun 5/105:25 pm
SFO
- TYS
2 stops21h 05m
Multiple Airlines
Deal found 3/23![Multiple Airlines logo]()
$324
Best flights from Knoxville to San FranciscoDiscover carefully curated flight deals from Knoxville to San Francisco that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated March 24, 2026.
Discover carefully curated flight deals from Knoxville to San Francisco that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated March 24, 2026.
This Southwest deal was found by Cheapflights users on 3/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 5/67:05 am
TYS
- SFO
2 stops11h 15m
Southwest
Tue 5/125:25 am
SFO
- TYS
2 stops11h 15m
Southwest
Deal found 3/22![Southwest logo]()
$332
This United Airlines deal was found by Cheapflights users on 3/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 5/17:00 am
TYS
- SFO
1 stop7h 24m
United Airlines
Sun 5/35:30 am
SFO
- TYS
1 stop8h 29m
United Airlines
Deal found 3/21![United Airlines logo]()
$384
This American Airlines deal was found by Cheapflights users on 3/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 5/156:54 pm
TYS
- SFO
1 stop8h 00m
American Airlines
Wed 5/207:00 am
SFO
- TYS
1 stop8h 13m
American Airlines
Deal found 3/21![American Airlines logo]()
$457
This Alaska Airlines deal was found by Cheapflights users on 3/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Alaska Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 4/244:09 pm
TYS
- SFO
2 stops9h 52m
Alaska Airlines
Tue 4/2810:10 am
SFO
- TYS
2 stops10h 46m
Alaska Airlines
Deal found 3/23![Alaska Airlines logo]()
$479
This Southwest deal was found by Cheapflights users on 3/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 4/256:40 am
TYS
- SFO
1 stop12h 40m
Southwest
Sat 5/25:40 am
SFO
- TYS
1 stop10h 55m
Southwest
Deal found 3/23![Southwest logo]()
$358
This United Airlines deal was found by Cheapflights users on 3/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 4/255:15 pm
TYS
- SFO
1 stop8h 15m
United Airlines
Sat 5/25:30 am
SFO
- TYS
1 stop8h 24m
United Airlines
Deal found 3/22![United Airlines logo]()
$384
This United Airlines deal was found by Cheapflights users on 3/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 4/287:00 am
TYS
- SFO
1 stop8h 03m
United Airlines
Tue 5/512:00 pm
SFO
- TYS
1 stop7h 23m
United Airlines
Deal found 3/21![United Airlines logo]()
$389
This United Airlines deal was found by Cheapflights users on 3/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 5/137:18 pm
TYS
- SFO
1 stop8h 58m
United Airlines
Sat 5/1612:00 pm
SFO
- TYS
1 stop7h 23m
United Airlines
Deal found 3/23![United Airlines logo]()
$389
This United Airlines deal was found by Cheapflights users on 3/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 4/247:00 am
TYS
- SFO
1 stop9h 12m
United Airlines
Tue 4/2811:52 pm
SFO
- TYS
1 stop7h 16m
United Airlines
Deal found 3/23![United Airlines logo]()
$414
This United Airlines deal was found by Cheapflights users on 3/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 4/157:05 am
TYS
- SFO
1 stop8h 13m
United Airlines
Sat 4/187:00 am
SFO
- TYS
1 stop9h 56m
United Airlines
Deal found 3/19![United Airlines logo]()
$489
Last-minute flights from Knoxville to San FranciscoDiscover last-minute flight deals from Knoxville to San Francisco. Data last updated March 24, 2026 and is based on user searches.
Discover last-minute flight deals from Knoxville to San Francisco. Data last updated March 24, 2026 and is based on user searches.
This CheapOair deal was found by Cheapflights users on 3/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure CheapOair is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 4/34:20 pm
TYS
- SFO
1 stop11h 03m
Frontier
Sun 4/59:00 pm
SFO
- TYS
1 stop15h 28m
Frontier
Deal found 3/23![Frontier logo]()
$316
This Expedia deal was found by Cheapflights users on 3/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Expedia is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 4/64:20 pm
TYS
- SFO
1 stop11h 08m
Frontier
Fri 4/106:00 am
SFO
- TYS
1 stop6h 28m
Frontier
Deal found 3/21![Frontier logo]()
$310
This United Airlines deal was found by Cheapflights users on 3/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 4/97:05 am
TYS
- SFO
1 stop8h 13m
United Airlines
Tue 4/215:00 am
SFO
- TYS
1 stop7h 06m
United Airlines
Deal found 3/19![United Airlines logo]()
$379
This Kiwi.com deal was found by Cheapflights users on 3/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 4/131:43 pm
TYS
- SFO
1 stop27h 09m
Multiple Airlines
Fri 4/1711:56 am
SFO
- TYS
2 stops48h 45m
Multiple Airlines
Deal found 3/20![Multiple Airlines logo]()
$357
This CheapOair deal was found by Cheapflights users on 3/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure CheapOair is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 4/164:28 pm
TYS
- SFO
1 stop19h 45m
Frontier
Sun 4/196:00 am
SFO
- TYS
1 stop6h 33m
Frontier
Deal found 3/20![Frontier logo]()
$221
This Kiwi.com deal was found by Cheapflights users on 3/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 4/164:28 pm
TYS
- SFO
1 stop19h 45m
Multiple Airlines
Sun 4/196:41 pm
SFO
- TYS
2 stops24h 43m
Multiple Airlines
Deal found 3/20![Multiple Airlines logo]()
$374
This Kiwi.com deal was found by Cheapflights users on 3/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 4/2311:27 am
TYS
- SFO
2 stops40h 00m
Multiple Airlines
Mon 4/278:48 am
SFO
- TYS
1 stop11h 03m
Multiple Airlines
Deal found 3/22![Multiple Airlines logo]()
$370
This Kiwi.com deal was found by Cheapflights users on 3/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 4/246:20 pm
TYS
- SFO
2 stops26h 14m
Multiple Airlines
Mon 4/278:48 am
SFO
- TYS
1 stop11h 03m
Multiple Airlines
Deal found 3/22![Multiple Airlines logo]()
$365
This Southwest deal was found by Cheapflights users on 3/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 4/256:40 am
TYS
- SFO
1 stop12h 40m
Southwest
Sat 5/25:40 am
SFO
- TYS
1 stop10h 55m
Southwest
Deal found 3/23![Southwest logo]()
$358
This United Airlines deal was found by Cheapflights users on 3/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 4/287:05 am
TYS
- SFO
1 stop8h 13m
United Airlines
Sat 5/211:10 am
SFO
- TYS
1 stop8h 13m
United Airlines
Deal found 3/24![United Airlines logo]()
$278
This American Airlines deal was found by Cheapflights users on 3/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 4/285:00 am
TYS
- SFO
1 stop10h 32m
American Airlines
Tue 5/511:30 pm
SFO
- TYS
1 stop8h 45m
American Airlines
Deal found 3/20![American Airlines logo]()
$369
One-way flights from Knoxville to San FranciscoSearch for one-way flight options from Knoxville to San Francisco. Find affordable one-way fares based on user searches. Data last updated March 24, 2026.
Search for one-way flight options from Knoxville to San Francisco. Find affordable one-way fares based on user searches. Data last updated March 24, 2026.
This United Airlines deal was found by Cheapflights users on 3/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 4/229:00 am
TYS
- SFO
1 stop8h 53m
United Airlines
Deal found 3/24![United Airlines logo]()
$127
This Frontier deal was found by Cheapflights users on 3/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Frontier is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 4/34:20 pm
TYS
- SFO
1 stop11h 03m
Frontier
Deal found 3/22![Frontier logo]()
$131
This Frontier deal was found by Cheapflights users on 3/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Frontier is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 4/104:20 pm
TYS
- SFO
1 stop11h 08m
Frontier
Deal found 3/22![Frontier logo]()
$137
This Kiwi.com deal was found by Cheapflights users on 3/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 5/151:15 pm
TYS
- SFO
2 stops30h 15m
Multiple Airlines
Deal found 3/21![Multiple Airlines logo]()
$147
This Kiwi.com deal was found by Cheapflights users on 3/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 5/86:20 pm
TYS
- SFO
2 stops25h 10m
Multiple Airlines
Deal found 3/21![Multiple Airlines logo]()
$149
This Kiwi.com deal was found by Cheapflights users on 3/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 4/201:43 pm
TYS
- SFO
1 stop27h 09m
Multiple Airlines
Deal found 3/22![Multiple Airlines logo]()
$150
This CheapOair deal was found by Cheapflights users on 3/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure CheapOair is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 6/18:32 pm
TYS
- SFO
1 stop18h 10m
Frontier
Deal found 3/24![Frontier logo]()
$157
This Frontier deal was found by Cheapflights users on 3/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Frontier is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 4/64:20 pm
TYS
- SFO
1 stop11h 08m
Frontier
Deal found 3/20![Frontier logo]()
$161
This Priceline deal was found by Cheapflights users on 3/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Priceline is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 3/304:20 pm
TYS
- SFO
1 stop11h 08m
Frontier
Deal found 3/22![Frontier logo]()
$166
Find flight deals from Knoxville to San Francisco
Discover tips and strategies to find the most affordable flight options for your journey from Knoxville (TYS) to San Francisco (SFO). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated March 24, 2026.
Most accurate provider | FlightHub 3 stars |
|---|---|
Most trusted provider | FlightHub 3 stars |
Round-trip from | $221 (CheapOair) |
One-way from | $127 (United Airlines) |
Popular in | December |
Cheapest in | February |
Average price | $471 |
Cheapflights Fare Finder
Customize your flight search to find flights from Knoxville to San Francisco that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated March 24, 2026.
Use the filters below to find and compare flights from Knoxville to San Francisco that are best for you.
Fly from
Fly to
Route
Depart
Return
Cheapest round-trip
KnoxvilleSan Francisco
TYS - SFO
TYSSFO
Knoxville McGhee Tyson
Wed 5/6
7:05 am-3:20 pm
2 stops11h 15m
San Francisco
Tue 5/12
5:25 am-7:40 pm
2 stops11h 15m
$332
KnoxvilleSan Francisco
TYS - SFO
TYSSFO
Knoxville McGhee Tyson
Sat 4/25
6:40 am-4:20 pm
1 stop12h 40m
San Francisco
Sat 5/2
5:40 am-7:35 pm
1 stop10h 55m
$358
KnoxvilleSan Francisco
TYS - SFO
TYSSFO
Knoxville McGhee Tyson
Fri 5/1
7:00 am-11:24 am
1 stop7h 24m
San Francisco
Sun 5/3
5:30 am-4:59 pm
1 stop8h 29m
$384
KnoxvilleSan Francisco
TYS - SFO
TYSSFO
Knoxville McGhee Tyson
Sat 4/25
5:15 pm-10:30 pm
1 stop8h 15m
San Francisco
Sat 5/2
5:30 am-4:54 pm
1 stop8h 24m
$384
Quickest round-trip
KnoxvilleSan Francisco
TYS - SFO
TYSSFO
Knoxville McGhee Tyson
Tue 4/28
7:00 am-12:03 pm
1 stop8h 03m
San Francisco
Tue 5/5
12:00 pm-10:23 pm
1 stop7h 23m
$389
KnoxvilleSan Francisco
TYS - SFO
TYSSFO
Knoxville McGhee Tyson
Wed 5/13
7:18 pm-1:16 am
1 stop8h 58m
San Francisco
Sat 5/16
12:00 pm-10:23 pm
1 stop7h 23m
$389
KnoxvilleSan Francisco
TYS - SFO
TYSSFO
Knoxville McGhee Tyson
Fri 4/24
7:00 am-1:12 pm
1 stop9h 12m
San Francisco
Tue 4/28
11:52 pm-10:08 am
1 stop7h 16m
$414
KnoxvilleSan Francisco
TYS - SFO
TYSSFO
Knoxville McGhee Tyson
Fri 5/15
6:54 pm-11:54 pm
1 stop8h 00m
San Francisco
Wed 5/20
7:00 am-6:13 pm
1 stop8h 13m
$457
KnoxvilleSan Francisco
TYS - SFO
TYSSFO
Knoxville McGhee Tyson
Fri 4/24
4:09 pm-11:01 pm
2 stops9h 52m
San Francisco
Tue 4/28
10:10 am-11:56 pm
2 stops10h 46m
$479
KnoxvilleSan Francisco
TYS - SFO
TYSSFO
Knoxville McGhee Tyson
Wed 4/15
7:05 am-12:18 pm
1 stop8h 13m
San Francisco
Sat 4/18
7:00 am-7:56 pm
1 stop9h 56m
$489
Showing 1-10 of 18 resultsSorted by cheapest first
Compare providers for flights from Knoxville to San Francisco
Provider information is updated monthly. Please note that these providers often have deals for this flight, but the availability may vary on a day-by-day basis on Cheapflights.
Use the table below to compare price accuracy, trust ratings, and cancellation policies for each provider offering flight deals from Knoxville to San Francisco in March.
| Provider | Price Accuracy | Trust Score* |
|---|---|---|
| Price Accuracy1 star | Trust Score*3 stars | |
| Price Accuracy3 stars | Trust Score*3 stars |
- Most accurate provider: When it comes to deals on Knoxville-San Francisco flights, users find the pricing of FlightHub to be most consistent on Cheapflights vs. FlightHub Users can find the same prices on Knoxville-San Francisco flight deals on Cheapflights vs. FlightHub >95% of the time. Price accuracy is based on data collected from Knoxville-San Francisco flight searches over the past month and is updated monthly.
- Most trusted provider: When it comes to deals on Knoxville-San Francisco flights, Cheapflights users trust FlightHub the most. FlightHub has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for Knoxville-San Francisco flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.
Best time to book a flight from Knoxville to San Francisco
Have a flexible travel schedule? Discover the best time to fly to San Francisco from Knoxville with our price prediction graph.
TYS-SFO
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.
Cheapflights Insights
Everything you need to know about your flight from Knoxville to San Francisco
How far ahead should I book a flight from Knoxville to San Francisco?
Use this chart to determine the optimal time to book a round-trip flight from Knoxville to San Francisco. Price data was last updated on March 13, 2026.
The best time to book flights from Knoxville to San Francisco is 27 days before your desired departure date. The cost of your flight will likely increase significantly if you book two weeks in advance of your flight.
What is the cheapest month to book a flight from Knoxville to San Francisco?
Currently, December is the cheapest month in which you can book a flight from Knoxville to San Francisco (average of $194). Flying from Knoxville to San Francisco in March is currently the most expensive (average of $324). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.
Reviews of airlines servicing San Francisco
Get insights into the airlines that provide service to San Francisco. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to San Francisco. Reviews last updated March 24, 2026.
Peruse reviews from past customers who have flown with Delta,United Airlines, andAmerican Airlines from Knoxville to San Francisco to help guide your decision. You can also see how each airline stacks up in terms of entertainment options, comfort, food, crew/service, and boarding process.
Comfort
7.9
Food
7.2
Boarding
8.1
Entertainment
7.8
Overall
7.9
Crew
8.5
Reviews
1 / 20
10.0
ExcellentAaron,Oct 2024
TUS - LAX
Comfort
7.9
Food
7.2
Boarding
8.1
Entertainment
7.8
Overall
7.9
Crew
8.5
Reviews
1 / 20
10.0
ExcellentAaron,Oct 2024
TUS - LAX
Comfort
7.9
Food
7.2
Boarding
8.1
Entertainment
7.8
Overall
7.9
Crew
8.5
Reviews
1 / 20
10.0
ExcellentAaron,Oct 2024
TUS - LAX
Comfort
7.9
Food
7.2
Boarding
8.1
Entertainment
7.8
Overall
7.9
Crew
8.5
Reviews
1 / 20
10.0
ExcellentAaron,Oct 2024
TUS - LAX
Comfort
7.9
Food
7.2
Boarding
8.1
Entertainment
7.8
Overall
7.9
Crew
8.5
Reviews
1 / 20
10.0
ExcellentAaron,Oct 2024
TUS - LAX
Related info for your journey
Find useful and relevant information for your journey from Knoxville to San Francisco. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.
Traveling to a place near San Francisco?
Book flights to San Francisco if you plan to visit one of these locationsSouth San Francisco
Santa Cruz
Santa Clara
Livermore
Roseville
Rancho Cordova
San Bruno
Watsonville
San Ramon
Sunnyvale
Vacaville
San Carlos
Turlock
Redwood City
San Lorenzo
Davis
Manteca
Union City
Elk Grove
Rohnert Park
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Knoxville and San Francisco flights
Browse other Knoxville and San Francisco flight options. Last updated on March 24, 2026.
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Browse through other flights departing from Knoxville. Flights are based on user searches made on Cheapflights and were last updated on March 24, 2026.
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Top 4 airlines flying from Knoxville to San Francisco
Discover the top 4 airlines that operate flights from Knoxville to San Francisco. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated March 24, 2026.
| Airline | Cheapest | Average | Flexibility | On-time |
|---|---|---|---|---|
| Cheapest$184 | Average$254 | FlexibilityNo cancel fee | On-time62% | |
| Cheapest$276 | Average$452 | FlexibilityNo cancel fee | On-timeN/A | |
| Cheapest$308 | Average$495 | FlexibilityNo cancel fee | On-time69% | |
| Cheapest$308 | Average$431 | FlexibilityNo cancel fee | On-time71% |