$136+ Cheap flights from Knoxville to San Francisco (TYS - SFO)
This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 3/10. Fares are subject to change and may not be available on all flights or dates of travel.
TYS — SFO
Mar 7 — Mar 141
1 adult, Economy
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Find cheap flights from Knoxville to San Francisco with Cheapflights
1. Tell us where you want to go
Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”2. Select your favorite providers
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Review each provider’s pricing and select the best option for you! Book through your favorite provider’s website for a seamless experience.Cheap flight deals from Knoxville to San Francisco
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Cheapest flights from Knoxville to San FranciscoExplore the most affordable flight options available from Knoxville to San Francisco. Find the lowest fares from popular airlines and budget airlines, with prices last updated on February 5, 2026.
Explore the most affordable flight options available from Knoxville to San Francisco. Find the lowest fares from popular airlines and budget airlines, with prices last updated on February 5, 2026.
This Frontier deal was found by Cheapflights users on 2/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Frontier is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 2/238:13 pm
TYS
- SFO
1 stop7h 15m
Frontier
Mon 3/26:15 am
SFO
- TYS
1 stop10h 03m
Frontier
Deal found 2/2![Frontier logo]()
$205
This Frontier deal was found by Cheapflights users on 2/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Frontier is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 2/276:51 pm
TYS
- SFO
1 stop8h 37m
Frontier
Mon 3/26:15 am
SFO
- TYS
1 stop10h 03m
Frontier
Deal found 2/2![Frontier logo]()
$219
This Frontier deal was found by Cheapflights users on 2/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Frontier is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 2/238:13 pm
TYS
- SFO
1 stop7h 15m
Frontier
Mon 3/96:00 am
SFO
- TYS
1 stop6h 25m
Frontier
Deal found 2/2![Frontier logo]()
$230
This Frontier deal was found by Cheapflights users on 2/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Frontier is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 2/208:12 pm
TYS
- SFO
1 stop7h 16m
Frontier
Mon 2/236:15 am
SFO
- TYS
1 stop10h 03m
Frontier
Deal found 2/4![Frontier logo]()
$235
This Frontier deal was found by Cheapflights users on 2/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Frontier is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 2/276:51 pm
TYS
- SFO
1 stop8h 37m
Frontier
Mon 3/96:00 am
SFO
- TYS
1 stop6h 25m
Frontier
Deal found 2/2![Frontier logo]()
$244
This Frontier deal was found by Cheapflights users on 2/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Frontier is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 4/164:28 pm
TYS
- SFO
1 stop10h 54m
Frontier
Thu 4/236:00 am
SFO
- TYS
1 stop6h 33m
Frontier
Deal found 2/2![Frontier logo]()
$256
This Kiwi.com deal was found by Cheapflights users on 2/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 3/27:21 pm
TYS
- SFO
2 stops29h 40m
Multiple Airlines
Mon 3/910:35 pm
SFO
- TYS
1 stop15h 59m
Multiple Airlines
Deal found 2/2![Multiple Airlines logo]()
$261
This Kiwi.com deal was found by Cheapflights users on 2/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 2/232:06 pm
TYS
- SFO
2 stops34h 33m
Multiple Airlines
Tue 3/37:15 pm
SFO
- TYS
1 stop20h 48m
Multiple Airlines
Deal found 2/2![Multiple Airlines logo]()
$275
This Expedia deal was found by Cheapflights users on 2/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Expedia is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 3/234:20 pm
TYS
- SFO
1 stop11h 08m
Frontier
Mon 4/66:00 am
SFO
- TYS
1 stop6h 28m
Frontier
Deal found 2/3![Frontier logo]()
$278
This Frontier deal was found by Cheapflights users on 2/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Frontier is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 2/138:12 pm
TYS
- SFO
1 stop7h 16m
Frontier
Fri 2/208:48 am
SFO
- TYS
1 stop7h 39m
Frontier
Deal found 2/2![Frontier logo]()
$280
This Kiwi.com deal was found by Cheapflights users on 2/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 2/232:06 pm
TYS
- SFO
2 stops34h 33m
Multiple Airlines
Sun 3/89:04 pm
SFO
- TYS
1 stop15h 21m
Multiple Airlines
Deal found 2/2![Multiple Airlines logo]()
$281
This Kiwi.com deal was found by Cheapflights users on 2/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 2/238:13 pm
TYS
- SFO
1 stop28h 48m
Multiple Airlines
Tue 3/107:32 pm
SFO
- TYS
1 stop20h 31m
Multiple Airlines
Deal found 2/2![Multiple Airlines logo]()
$282
Best flights from Knoxville to San FranciscoDiscover carefully curated flight deals from Knoxville to San Francisco that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated February 5, 2026.
Discover carefully curated flight deals from Knoxville to San Francisco that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated February 5, 2026.
This Kiwi.com deal was found by Cheapflights users on 2/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 3/410:00 am
TYS
- SFO
1 stop24h 48m
Multiple Airlines
Wed 3/1110:38 pm
SFO
- TYS
2 stops19h 49m
Multiple Airlines
Deal found 2/2![Multiple Airlines logo]()
$327
This United Airlines deal was found by Cheapflights users on 2/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 2/267:25 pm
TYS
- SFO
1 stop9h 03m
United Airlines
Mon 3/211:59 pm
SFO
- TYS
1 stop7h 13m
United Airlines
Deal found 2/4![United Airlines logo]()
$329
This American Airlines deal was found by Cheapflights users on 2/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 5/308:09 pm
TYS
- SFO
1 stop7h 36m
American Airlines
Tue 6/210:05 pm
SFO
- TYS
1 stop9h 47m
American Airlines
Deal found 2/4![American Airlines logo]()
$329
This Delta deal was found by Cheapflights users on 2/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 4/87:40 am
TYS
- SFO
1 stop10h 02m
Delta
Sat 4/1110:40 pm
SFO
- TYS
1 stop8h 51m
Delta
Deal found 2/3![Delta logo]()
$364
This United Airlines deal was found by Cheapflights users on 2/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 4/237:00 am
TYS
- SFO
1 stop8h 03m
United Airlines
Sat 4/2512:10 pm
SFO
- TYS
1 stop7h 19m
United Airlines
Deal found 2/4![United Airlines logo]()
$329
This Kiwi.com deal was found by Cheapflights users on 2/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 4/234:28 pm
TYS
- SFO
1 stop10h 54m
Multiple Airlines
Sat 4/256:00 am
SFO
- TYS
2 stops30h 41m
Multiple Airlines
Deal found 2/4![Multiple Airlines logo]()
$333
This American Airlines deal was found by Cheapflights users on 2/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 3/1012:21 pm
TYS
- SFO
1 stop7h 45m
American Airlines
Sun 3/1511:29 pm
SFO
- TYS
1 stop8h 19m
American Airlines
Deal found 2/3![American Airlines logo]()
$359
This United Airlines deal was found by Cheapflights users on 2/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 4/187:00 am
TYS
- SFO
1 stop8h 03m
United Airlines
Tue 4/215:00 am
SFO
- TYS
1 stop7h 06m
United Airlines
Deal found 2/5![United Airlines logo]()
$329
This Kiwi.com deal was found by Cheapflights users on 2/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 4/104:20 pm
TYS
- SFO
1 stop11h 03m
Multiple Airlines
Mon 4/209:13 am
SFO
- TYS
1 stop10h 38m
Multiple Airlines
Deal found 2/4![Multiple Airlines logo]()
$351
This United Airlines deal was found by Cheapflights users on 2/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 5/277:20 pm
TYS
- SFO
1 stop8h 56m
United Airlines
Tue 6/211:30 pm
SFO
- TYS
1 stop7h 34m
United Airlines
Deal found 2/3![United Airlines logo]()
$329
This American Airlines deal was found by Cheapflights users on 2/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 2/194:15 pm
TYS
- SFO
1 stop9h 55m
American Airlines
Sat 2/286:00 am
SFO
- TYS
1 stop9h 37m
American Airlines
Deal found 2/5![American Airlines logo]()
$369
This Kiwi.com deal was found by Cheapflights users on 2/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 3/1011:00 am
TYS
- SFO
2 stops40h 28m
Multiple Airlines
Sun 3/159:04 pm
SFO
- TYS
1 stop15h 21m
Multiple Airlines
Deal found 2/4![Multiple Airlines logo]()
$386
Last-minute flights from Knoxville to San FranciscoDiscover last-minute flight deals from Knoxville to San Francisco. Data last updated February 5, 2026 and is based on user searches.
Discover last-minute flight deals from Knoxville to San Francisco. Data last updated February 5, 2026 and is based on user searches.
This Frontier deal was found by Cheapflights users on 2/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Frontier is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 2/138:12 pm
TYS
- SFO
1 stop7h 16m
Frontier
Fri 2/208:48 am
SFO
- TYS
1 stop7h 39m
Frontier
Deal found 2/2![Frontier logo]()
$280
This Frontier deal was found by Cheapflights users on 2/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Frontier is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 2/208:12 pm
TYS
- SFO
1 stop7h 16m
Frontier
Mon 2/236:15 am
SFO
- TYS
1 stop10h 03m
Frontier
Deal found 2/4![Frontier logo]()
$235
This Frontier deal was found by Cheapflights users on 2/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Frontier is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 2/238:13 pm
TYS
- SFO
1 stop7h 15m
Frontier
Mon 3/26:15 am
SFO
- TYS
1 stop10h 03m
Frontier
Deal found 2/2![Frontier logo]()
$205
This Frontier deal was found by Cheapflights users on 2/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Frontier is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 2/238:13 pm
TYS
- SFO
1 stop7h 15m
Frontier
Mon 3/96:00 am
SFO
- TYS
1 stop6h 25m
Frontier
Deal found 2/2![Frontier logo]()
$230
This Kiwi.com deal was found by Cheapflights users on 2/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 2/232:06 pm
TYS
- SFO
2 stops34h 33m
Multiple Airlines
Tue 3/107:32 pm
SFO
- TYS
1 stop20h 31m
Multiple Airlines
Deal found 2/2![Multiple Airlines logo]()
$275
This Kiwi.com deal was found by Cheapflights users on 2/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 2/232:06 pm
TYS
- SFO
2 stops34h 33m
Multiple Airlines
Sun 3/89:04 pm
SFO
- TYS
1 stop15h 21m
Multiple Airlines
Deal found 2/2![Multiple Airlines logo]()
$281
This Kiwi.com deal was found by Cheapflights users on 2/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 2/238:13 pm
TYS
- SFO
1 stop28h 48m
Multiple Airlines
Tue 3/37:15 pm
SFO
- TYS
1 stop20h 48m
Multiple Airlines
Deal found 2/2![Multiple Airlines logo]()
$282
This Kiwi.com deal was found by Cheapflights users on 2/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 2/232:06 pm
TYS
- SFO
2 stops34h 33m
Multiple Airlines
Mon 3/910:35 pm
SFO
- TYS
1 stop15h 59m
Multiple Airlines
Deal found 2/2![Multiple Airlines logo]()
$284
This Frontier deal was found by Cheapflights users on 2/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Frontier is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 2/276:51 pm
TYS
- SFO
1 stop8h 37m
Frontier
Mon 3/26:15 am
SFO
- TYS
1 stop10h 03m
Frontier
Deal found 2/2![Frontier logo]()
$219
This Frontier deal was found by Cheapflights users on 2/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Frontier is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 2/276:51 pm
TYS
- SFO
1 stop8h 37m
Frontier
Mon 3/96:00 am
SFO
- TYS
1 stop6h 25m
Frontier
Deal found 2/2![Frontier logo]()
$244
This Kiwi.com deal was found by Cheapflights users on 2/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 3/27:21 pm
TYS
- SFO
2 stops29h 40m
Multiple Airlines
Mon 3/910:35 pm
SFO
- TYS
1 stop15h 59m
Multiple Airlines
Deal found 2/2![Multiple Airlines logo]()
$261
This Expedia deal was found by Cheapflights users on 2/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Expedia is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 3/234:20 pm
TYS
- SFO
1 stop11h 08m
Frontier
Mon 4/66:00 am
SFO
- TYS
1 stop6h 28m
Frontier
Deal found 2/3![Frontier logo]()
$278
One-way flights from Knoxville to San FranciscoSearch for one-way flight options from Knoxville to San Francisco. Find affordable one-way fares based on user searches. Data last updated February 5, 2026.
Search for one-way flight options from Knoxville to San Francisco. Find affordable one-way fares based on user searches. Data last updated February 5, 2026.
This Kiwi.com deal was found by Cheapflights users on 2/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 3/1011:00 am
TYS
- SFO
2 stops40h 28m
Multiple Airlines
Deal found 2/3![Multiple Airlines logo]()
$136
This Kiwi.com deal was found by Cheapflights users on 2/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 3/94:20 pm
TYS
- SFO
1 stop30h 49m
Frontier
Deal found 2/2![Frontier logo]()
$137
This Kiwi.com deal was found by Cheapflights users on 2/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 4/201:43 pm
TYS
- SFO
1 stop27h 43m
Multiple Airlines
Deal found 2/4![Multiple Airlines logo]()
$157
This Kiwi.com deal was found by Cheapflights users on 2/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 3/1811:30 am
TYS
- SFO
3 stops47h 28m
Multiple Airlines
Deal found 2/4![Multiple Airlines logo]()
$163
This American Airlines deal was found by Cheapflights users on 2/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 4/76:00 am
TYS
- SFO
1 stop8h 05m
American Airlines
Deal found 2/5![American Airlines logo]()
$165
This Kiwi.com deal was found by Cheapflights users on 2/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 5/41:43 pm
TYS
- SFO
1 stop30h 09m
Multiple Airlines
Deal found 2/3![Multiple Airlines logo]()
$170
This Kiwi.com deal was found by Cheapflights users on 2/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 3/99:36 pm
TYS
- SFO
3 stops25h 33m
Multiple Airlines
Deal found 2/2![Multiple Airlines logo]()
$171
This Kiwi.com deal was found by Cheapflights users on 2/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 4/128:00 am
TYS
- SFO
1 stop27h 16m
Multiple Airlines
Deal found 2/3![Multiple Airlines logo]()
$175
This Kiwi.com deal was found by Cheapflights users on 2/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 2/288:00 am
TYS
- SFO
2 stops17h 21m
Multiple Airlines
Deal found 2/3![Multiple Airlines logo]()
$179
This United Airlines deal was found by Cheapflights users on 2/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 5/57:18 pm
TYS
- SFO
1 stop8h 58m
United Airlines
Deal found 2/1![United Airlines logo]()
$183
Find flight deals from Knoxville to San Francisco
Discover tips and strategies to find the most affordable flight options for your journey from Knoxville (TYS) to San Francisco (SFO). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated February 5, 2026.
Most accurate provider | FlightHub 3 stars |
|---|---|
Most trusted provider | FlightHub 3 stars |
Round-trip from | $235 (Frontier) |
One-way from | $136 (Kiwi.com) |
Popular in | December |
Cheapest in | February |
Average price | $338 |
Cheapflights Fare Finder
Customize your flight search to find flights from Knoxville to San Francisco that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated February 5, 2026.
Use the filters below to find and compare flights from Knoxville to San Francisco that are best for you.
Fly from
Knoxville
Fly to
San Francisco
Route
Depart
Return
Price
KnoxvilleSan Francisco
TYS - SFO
TYSSFO
Knoxville McGhee Tyson
Wed 3/4
10:00 am-7:48 am
1 stop24h 48m
San Francisco
Wed 3/11
10:38 pm-9:27 pm
2 stops19h 49m
$327
KnoxvilleSan Francisco
TYS - SFO
TYSSFO
Knoxville McGhee Tyson
Thu 2/26
7:25 pm-1:28 am
1 stop9h 03m
San Francisco
Mon 3/2
11:59 pm-10:12 am
1 stop7h 13m
$329
KnoxvilleSan Francisco
TYS - SFO
TYSSFO
Knoxville McGhee Tyson
Sat 5/30
8:09 pm-12:45 am
1 stop7h 36m
San Francisco
Tue 6/2
10:05 pm-10:52 am
1 stop9h 47m
$329
KnoxvilleSan Francisco
TYS - SFO
TYSSFO
Knoxville McGhee Tyson
Thu 4/23
7:00 am-12:03 pm
1 stop8h 03m
San Francisco
Sat 4/25
12:10 pm-10:29 pm
1 stop7h 19m
$329
KnoxvilleSan Francisco
TYS - SFO
TYSSFO
Knoxville McGhee Tyson
Sat 4/18
7:00 am-12:03 pm
1 stop8h 03m
San Francisco
Tue 4/21
5:00 am-3:06 pm
1 stop7h 06m
$329
KnoxvilleSan Francisco
TYS - SFO
TYSSFO
Knoxville McGhee Tyson
Wed 5/27
7:20 pm-1:16 am
1 stop8h 56m
San Francisco
Tue 6/2
11:30 pm-10:04 am
1 stop7h 34m
$329
KnoxvilleSan Francisco
TYS - SFO
TYSSFO
Knoxville McGhee Tyson
Thu 4/23
4:28 pm-12:22 am
1 stop10h 54m
San Francisco
Sat 4/25
6:00 am-3:41 pm
2 stops30h 41m
$333
KnoxvilleSan Francisco
TYS - SFO
TYSSFO
Knoxville McGhee Tyson
Fri 4/10
4:20 pm-12:23 am
1 stop11h 03m
San Francisco
Mon 4/20
9:13 am-10:51 pm
1 stop10h 38m
$351
KnoxvilleSan Francisco
TYS - SFO
TYSSFO
Knoxville McGhee Tyson
Tue 3/10
12:21 pm-5:06 pm
1 stop7h 45m
San Francisco
Sun 3/15
11:29 pm-10:48 am
1 stop8h 19m
$359
KnoxvilleSan Francisco
TYS - SFO
TYSSFO
Knoxville McGhee Tyson
Wed 4/8
7:40 am-2:42 pm
1 stop10h 02m
San Francisco
Sat 4/11
10:40 pm-10:31 am
1 stop8h 51m
$364
Showing 1-10 of 20 results
Compare providers for flights from Knoxville to San Francisco
Provider information is updated monthly. Please note that these providers often have deals for this flight, but the availability may vary on a day-by-day basis on Cheapflights.
Use the table below to compare price accuracy, trust ratings, and cancellation policies for each provider offering flight deals from Knoxville to San Francisco in February.
| Provider | Price Accuracy | Trust Score* |
|---|---|---|
| Price Accuracy1 star | Trust Score*3 stars | |
| Price Accuracy3 stars | Trust Score*3 stars |
- Most accurate provider: When it comes to deals on Knoxville-San Francisco flights, users find the pricing of FlightHub to be most consistent on Cheapflights vs. FlightHub Users can find the same prices on Knoxville-San Francisco flight deals on Cheapflights vs. FlightHub >95% of the time. Price accuracy is based on data collected from Knoxville-San Francisco flight searches over the past month and is updated monthly.
- Most trusted provider: When it comes to deals on Knoxville-San Francisco flights, Cheapflights users trust FlightHub the most. FlightHub has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for Knoxville-San Francisco flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.
Best time to book a flight from Knoxville to San Francisco
Have a flexible travel schedule? Discover the best time to fly to San Francisco from Knoxville with our price prediction graph.
TYS-SFO
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.
Cheapflights Insights
Everything you need to know about your flight from Knoxville to San Francisco
How far ahead should I book a flight from Knoxville to San Francisco?
Use this chart to determine the optimal time to book a round-trip flight from Knoxville to San Francisco. Price data was last updated on January 30, 2026.
The best time to book flights from Knoxville to San Francisco is 27 days before your desired departure date. The cost of your flight will likely increase significantly if you book two weeks in advance of your flight.
What is the cheapest month to book a flight from Knoxville to San Francisco?
Currently, December is the cheapest month in which you can book a flight from Knoxville to San Francisco (average of $194). Flying from Knoxville to San Francisco in March is currently the most expensive (average of $289). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.
Reviews of airlines servicing San Francisco
Get insights into the airlines that provide service to San Francisco. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to San Francisco. Reviews last updated February 5, 2026.
Peruse reviews from past customers who have flown with Delta, United Airlines, and American Airlines from Knoxville to San Francisco to help guide your decision. You can also see how each airline stacks up in terms of entertainment options, comfort, food, crew/service, and boarding process.
Overall
7.9
Entertainment
7.8
Crew
8.5
Food
7.2
Boarding
8.1
Comfort
7.9
Reviews
1 / 20
10.0
ExcellentAaron,Oct 2024
TUS - LAX
Overall
7.9
Entertainment
7.8
Crew
8.5
Food
7.2
Boarding
8.1
Comfort
7.9
Reviews
1 / 20
10.0
ExcellentAaron,Oct 2024
TUS - LAX
Overall
7.9
Entertainment
7.8
Crew
8.5
Food
7.2
Boarding
8.1
Comfort
7.9
Reviews
1 / 20
10.0
ExcellentAaron,Oct 2024
TUS - LAX
Overall
7.9
Entertainment
7.8
Crew
8.5
Food
7.2
Boarding
8.1
Comfort
7.9
Reviews
1 / 20
10.0
ExcellentAaron,Oct 2024
TUS - LAX
Overall
7.9
Entertainment
7.8
Crew
8.5
Food
7.2
Boarding
8.1
Comfort
7.9
Reviews
1 / 20
10.0
ExcellentAaron,Oct 2024
TUS - LAX
Related info for your journey
Find useful and relevant information for your journey from Knoxville to San Francisco. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.
Traveling to a place near San Francisco?
Book flights to San Francisco if you plan to visit one of these locationsSouth San Francisco
Santa Cruz
Santa Clara
Roseville
Livermore
Watsonville
San Bruno
Daly City
Sunnyvale
Turlock
Vacaville
San Carlos
San Ramon
San Lorenzo
Davis
Hollister
Redwood City
Manteca
Union City
Elk Grove
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Knoxville and San Francisco flights
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Top 4 airlines flying from Knoxville to San Francisco
Discover the top 4 airlines that operate flights from Knoxville to San Francisco. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated February 5, 2026.
| Airline | Cheapest | Average | Flexibility | On-time |
|---|---|---|---|---|
| Cheapest$157 | Average$268 | FlexibilityNo cancel fee | On-time62% | |
| Cheapest$286 | Average$464 | FlexibilityNo cancel fee | On-time69% | |
| Cheapest$302 | Average$438 | FlexibilityNo cancel fee | On-timeN/A | |
| Cheapest$308 | Average$415 | FlexibilityNo cancel fee | On-time71% |