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$80+ Cheap flights from Knoxville to San Francisco (TYS - SFO)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 9/29. Fares are subject to change and may not be available on all flights or dates of travel.
TYS — SFO
Aug 24 — Aug 311
Sun 8/24
Sun 8/31
1 adult, Economy
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Cheapflights Tip: The best prices from Knoxville McGhee Tyson to San Francisco are usually found in January or February, booked 44 days in advance, depart on a Tuesday or Wednesday and return on a Tuesday

Cheap flight deals from Knoxville to San Francisco

Discover tips and strategies to find the most affordable flight options for your journey from Knoxville (TYS) to San Francisco (SFO). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated August 19, 2025.

Round-trip from

$309
(American Airlines)

One-way from

$80
(Priceline)

Popular in

December

Cheapest in

January

Average price

$438
From Knoxville McGhee Tyson to San Francisco
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One-way flight from Knoxville McGhee Tyson to San Francisco
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Highest demand for flights based on searches. 2% potential increase in price ($9 potential increase over avg. RT price).
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Cheapest flight prices on average. 1% potential price decrease ($6 potential savings vs. average RT price).
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Average for round-trip flights in August 2025
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Find flight deals from Knoxville to San Francisco

Cheapest flights from Knoxville to San Francisco
Explore the most affordable flight options available from Knoxville to San Francisco. Find the lowest fares from popular airlines and budget airlines, with prices last updated on August 19, 2025.

This American Airlines deal was found by Cheapflights users on 8/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/176:24 pmTYS - SFO
1 stop7h 51mAmerican Airlines
Wed 9/248:00 amSFO - TYS
1 stop7h 50mAmerican Airlines
Deal found 8/18$309
This Kiwi.com deal was found by Cheapflights users on 8/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/237:00 amTYS - SFO
1 stop10h 24mMultiple Airlines
Sun 10/268:27 pmSFO - TYS
2 stops23h 26mMultiple Airlines
Deal found 8/19$311
This Kiwi.com deal was found by Cheapflights users on 8/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/97:00 amTYS - SFO
1 stop10h 24mMultiple Airlines
Mon 10/1310:23 pmSFO - TYS
2 stops34h 32mMultiple Airlines
Deal found 8/16$327
This Kiwi.com deal was found by Cheapflights users on 8/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 9/47:35 pmTYS - SFO
2 stops28h 46mMultiple Airlines
Sun 9/710:49 amSFO - TYS
1 stop9h 01mMultiple Airlines
Deal found 8/19$337
This Delta deal was found by Cheapflights users on 8/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 9/41:53 pmTYS - SFO
1 stop7h 59mDelta
Wed 9/106:15 amSFO - TYS
1 stop6h 19mDelta
Deal found 8/19$339
This American Airlines deal was found by Cheapflights users on 8/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/36:00 amTYS - SFO
1 stop10h 10mAmerican Airlines
Sat 9/67:00 amSFO - TYS
1 stop7h 54mAmerican Airlines
Deal found 8/17$369
This American Airlines deal was found by Cheapflights users on 8/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 11/1412:08 pmTYS - SFO
2 stops9h 16mAmerican Airlines
Mon 11/1711:59 pmSFO - TYS
1 stop8h 24mAmerican Airlines
Deal found 8/18$379
This Kiwi.com deal was found by Cheapflights users on 8/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 8/292:29 pmTYS - SFO
1 stop9h 52mMultiple Airlines
Wed 9/38:00 amSFO - TYS
2 stops26h 43mMultiple Airlines
Deal found 8/17$388
This Frontier deal was found by Cheapflights users on 8/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Frontier is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 9/48:40 pmTYS - SFO
2 stops14h 56mFrontier
Sun 9/710:37 pmSFO - TYS
2 stops18h 08mFrontier
Deal found 8/19$393

Cheapflights Fare Finder

 
Customize your flight search to find flights from Knoxville to San Francisco that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated August 19, 2025.
Use the filters below to find and compare flights from Knoxville to San Francisco that are best for you.

Fly from

Knoxville

Fly to

San Francisco

Route

Depart

Return

Price

KnoxvilleSan Francisco

TYS - SFO

TYSSFO

Knoxville McGhee Tyson

Fri 11/14

1:13 pm-8:37 pm

1 stop10h 24m

San Francisco

Mon 11/17

11:59 pm-11:23 am

1 stop8h 24m

$309

KnoxvilleSan Francisco

TYS - SFO

TYSSFO

Knoxville McGhee Tyson

Sat 10/4

4:40 pm-10:57 pm

1 stop9h 17m

San Francisco

Mon 10/13

10:45 pm-10:29 am

1 stop8h 44m

$309

KnoxvilleSan Francisco

TYS - SFO

TYSSFO

Knoxville McGhee Tyson

Wed 9/17

6:00 am-1:10 pm

1 stop10h 10m

San Francisco

Tue 9/23

12:47 am-12:21 pm

1 stop8h 34m

$309

KnoxvilleSan Francisco

TYS - SFO

TYSSFO

Knoxville McGhee Tyson

Thu 10/23

7:00 am-2:24 pm

1 stop10h 24m

San Francisco

Sun 10/26

8:27 pm-10:53 pm

2 stops23h 26m

$311

KnoxvilleSan Francisco

TYS - SFO

TYSSFO

Knoxville McGhee Tyson

Thu 10/9

7:00 am-2:24 pm

1 stop10h 24m

San Francisco

Mon 10/13

10:23 pm-11:55 am

2 stops34h 32m

$327

KnoxvilleSan Francisco

TYS - SFO

TYSSFO

Knoxville McGhee Tyson

Thu 9/4

7:35 pm-9:21 pm

2 stops28h 46m

San Francisco

Sun 9/7

10:49 am-10:50 pm

1 stop9h 01m

$337

KnoxvilleSan Francisco

TYS - SFO

TYSSFO

Knoxville McGhee Tyson

Thu 9/4

1:53 pm-6:52 pm

1 stop7h 59m

San Francisco

Wed 9/10

6:15 am-3:34 pm

1 stop6h 19m

$339

KnoxvilleSan Francisco

TYS - SFO

TYSSFO

Knoxville McGhee Tyson

Thu 9/4

6:24 pm-11:15 pm

1 stop7h 51m

San Francisco

Tue 9/9

5:45 am-3:41 pm

1 stop6h 56m

$339

KnoxvilleSan Francisco

TYS - SFO

TYSSFO

Knoxville McGhee Tyson

Wed 9/3

6:00 am-1:10 pm

1 stop10h 10m

San Francisco

Sat 9/6

7:00 am-5:54 pm

1 stop7h 54m

$369

KnoxvilleSan Francisco

TYS - SFO

TYSSFO

Knoxville McGhee Tyson

Mon 9/29

8:35 pm-12:16 am

1 stop6h 41m

$80

Flights are sorted by cheapest round-trip flights first.

Deals found on 8/18

Showing 1-10 of 18 results
1
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Best time to book a flight from Knoxville to San Francisco

Have a flexible travel schedule? Discover the best time to fly to San Francisco from Knoxville with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Knoxville to San Francisco

How far ahead should I book a flight from Knoxville to San Francisco?

Use this chart to determine the optimal time to book a round-trip flight from Knoxville to San Francisco. Price data was last updated on August 8, 2025.

The best time to book flights from Knoxville to San Francisco is 44 days before your desired departure date. The cost of your flight will likely increase significantly if you book two weeks in advance of your flight.

What is the cheapest month to book a flight from Knoxville to San Francisco?

Currently, January is the cheapest month in which you can book a flight from Knoxville to San Francisco (average of $276). Flying from Knoxville to San Francisco in June is currently the most expensive (average of $358). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from TYS to SFO?

Find hourly flight availability from Knoxville to San Francisco. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated August 19, 2025.

One of the essential ways to save on airfare from Knoxville to San Francisco is to remain as flexible as possible. Flights that are in the morning tend to be the most expensive. A flight in the evening could potentially save you up to 30% on airfare.

What is the cheapest day to fly from Knoxville to San Francisco?

Use this chart to determine the cheapest time to fly round-trip from Knoxville to San Francisco. Price data was last updated on December 16, 2024.

Travelers seeking maximum savings on their Knoxville to San Francisco flight should consider departing on Sunday afternoons when fares are most often at their lowest. Sunday evenings flights should be avoided if possible as fares are typically the most expensive at this time.

Reviews of airlines servicing San Francisco

Get insights into the airlines that provide service to San Francisco. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to San Francisco. Reviews last updated August 19, 2025.
Peruse reviews from past customers who have flown with Delta, United Airlines, and American Airlines from Knoxville to San Francisco to help guide your decision. You can also see how each airline stacks up in terms of entertainment options, comfort, food, crew/service, and boarding process.
Delta
8.0
Very good
7,981 reviews

Entertainment

7.9

Food

7.3

Comfort

7.9

Boarding

8.2

Crew

8.5

Overall

8.0

Reviews

1 / 20
10.0
Excellent

Aaron,Oct 2024

TUS - LAX

Delta has consistently been the best U.S. airline for my travels and this flight was no exception
Delta
8.0
Very good
7,981 reviews
Delta
8.0
Very good
7,981 reviews

Entertainment

7.9

Food

7.3

Comfort

7.9

Boarding

8.2

Crew

8.5

Overall

8.0

Reviews

1 / 20
10.0
Excellent

Aaron,Oct 2024

TUS - LAX

Delta has consistently been the best U.S. airline for my travels and this flight was no exception
United Airlines
7.4
Good
8,922 reviews
Delta
8.0
Very good
7,981 reviews

Entertainment

7.9

Food

7.3

Comfort

7.9

Boarding

8.2

Crew

8.5

Overall

8.0

Reviews

1 / 20
10.0
Excellent

Aaron,Oct 2024

TUS - LAX

Delta has consistently been the best U.S. airline for my travels and this flight was no exception
American Airlines
7.2
Good
10,000 reviews
Delta
8.0
Very good
7,981 reviews

Entertainment

7.9

Food

7.3

Comfort

7.9

Boarding

8.2

Crew

8.5

Overall

8.0

Reviews

1 / 20
10.0
Excellent

Aaron,Oct 2024

TUS - LAX

Delta has consistently been the best U.S. airline for my travels and this flight was no exception
Frontier
5.8
Fair
3,211 reviews
Delta
8.0
Very good
7,981 reviews

Entertainment

7.9

Food

7.3

Comfort

7.9

Boarding

8.2

Crew

8.5

Overall

8.0

Reviews

1 / 20
10.0
Excellent

Aaron,Oct 2024

TUS - LAX

Delta has consistently been the best U.S. airline for my travels and this flight was no exception

Related info for your journey

Find useful and relevant information for your journey from Knoxville to San Francisco. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • How long is the flight from Knoxville to San Francisco?

    Departing from Knoxville to San Francisco will take you 9h 17m. The distance between Knoxville and San Francisco is about 2114 mi. Both multi-stop and nonstop flights can be found to your destination and back.

  • What are the cheapest airlines flying from Knoxville to San Francisco round-trip?

    Flying on Frontier is currently your cheapest option to San Francisco, with prices starting at $155. Additional round-trip tickets that might be worth considering are offered by United Airlines and Delta, with the lowest prices starting at $248 and $308, respectively. Frontier is priced at 62% lower than the current average price of a flight leaving 3 months from now.

  • Can I find deals for flights from Knoxville to San Francisco that include hotel bookings?

    Yes. In addition to deals on Knoxville to San Francisco flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Knoxville to San Francisco?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Knoxville to San Francisco.

  • Can I find deals for business class flights from Knoxville to San Francisco?

    Yes. Cheapflights offers flight deals from Knoxville to San Francisco by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Knoxville to San Francisco?

    Currently, January is the cheapest month in which you can book a flight from Knoxville to San Francisco (average of $276). Flying from Knoxville to San Francisco in June is currently the most expensive (average of $358). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Traveling to a place near San Francisco?

Book flights to San Francisco if you plan to visit one of these locations
Roseville
Santa Cruz
Livermore
South San Francisco
Mountain View
Turlock
Santa Clara
Hollister
Antioch
Watsonville
Manteca
Newark
Milpitas
Sunnyvale
Campbell
Foster City
San Leandro
Burlingame
Redwood City
Vallejo

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Top 4 airlines flying from Knoxville to San Francisco

Discover the top 4 airlines that operate flights from Knoxville to San Francisco. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated August 19, 2025.
AirlineCheapestAverageFlexibilityOn-time
FrontierCheapest$155Average$254FlexibilityNo cancel feeOn-time62%
United AirlinesCheapest$248Average$517FlexibilityNo cancel feeOn-time69%
DeltaCheapest$308Average$411FlexibilityNo cancel feeOn-timeN/A
American AirlinesCheapest$308Average$414FlexibilityNo cancel feeOn-time71%

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