$119+ Cheap flights from Knoxville to San Francisco (TYS - SFO)
This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 5/15. Fares are subject to change and may not be available on all flights or dates of travel.
TYS — SFO
May 9 — May 161
Round-trip
1 adult, Economy
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Find cheap flights from Knoxville to San Francisco with Cheapflights
1. Tell us where you want to go
Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”2. Select your favorite providers
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Review each provider’s pricing and select the best option for you! Book through your favorite provider’s website for a seamless experience.Cheap flight deals from Knoxville to San Francisco
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Best
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Cheapest flights from Knoxville to San FranciscoExplore the most affordable flight options available from Knoxville to San Francisco. Find the lowest fares from popular airlines and budget airlines, with prices last updated on April 9, 2026.
Explore the most affordable flight options available from Knoxville to San Francisco. Find the lowest fares from popular airlines and budget airlines, with prices last updated on April 9, 2026.
This Priceline deal was found by Cheapflights users on 4/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Priceline is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 4/304:28 pm
TYS
- SFO
1 stop10h 59m
Frontier
Sun 5/36:00 am
SFO
- TYS
1 stop6h 33m
Frontier
Deal found 4/5![Frontier logo]()
$230
This Frontier deal was found by Cheapflights users on 4/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Frontier is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 5/298:19 pm
TYS
- SFO
1 stop7h 04m
Frontier
Wed 6/36:00 am
SFO
- TYS
1 stop10h 33m
Frontier
Deal found 4/6![Frontier logo]()
$270
This CheapOair deal was found by Cheapflights users on 4/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure CheapOair is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 5/228:19 pm
TYS
- SFO
1 stop14h 42m
Frontier
Mon 5/256:00 am
SFO
- TYS
1 stop10h 24m
Frontier
Deal found 4/6![Frontier logo]()
$281
This Kiwi.com deal was found by Cheapflights users on 4/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 5/151:43 pm
TYS
- SFO
1 stop23h 53m
Multiple Airlines
Sun 5/1710:15 pm
SFO
- TYS
2 stops18h 18m
Multiple Airlines
Deal found 4/7![Multiple Airlines logo]()
$299
This CheapOair deal was found by Cheapflights users on 4/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure CheapOair is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 5/118:32 pm
TYS
- SFO
1 stop18h 15m
Frontier
Fri 5/156:00 am
SFO
- TYS
1 stop10h 33m
Frontier
Deal found 4/6![Frontier logo]()
$322
This Kiwi.com deal was found by Cheapflights users on 4/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 5/81:15 pm
TYS
- SFO
2 stops22h 15m
Multiple Airlines
Sun 5/1010:40 pm
SFO
- TYS
1 stop21h 11m
Multiple Airlines
Deal found 4/7![Multiple Airlines logo]()
$326
This Kiwi.com deal was found by Cheapflights users on 4/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 5/282:49 pm
TYS
- SFO
1 stop28h 41m
Multiple Airlines
Wed 6/310:40 pm
SFO
- TYS
2 stops35h 14m
Multiple Airlines
Deal found 4/6![Multiple Airlines logo]()
$328
This Kiwi.com deal was found by Cheapflights users on 4/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 4/271:43 pm
TYS
- SFO
1 stop27h 09m
Multiple Airlines
Tue 5/193:26 pm
SFO
- TYS
2 stops43h 33m
Multiple Airlines
Deal found 4/6![Multiple Airlines logo]()
$332
This Kiwi.com deal was found by Cheapflights users on 4/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 5/78:00 am
TYS
- SFO
1 stop11h 30m
Multiple Airlines
Mon 5/1111:31 am
SFO
- TYS
1 stop8h 20m
Multiple Airlines
Deal found 4/8![Multiple Airlines logo]()
$336
This CheapOair deal was found by Cheapflights users on 4/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure CheapOair is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 4/264:28 pm
TYS
- SFO
1 stop10h 59m
Frontier
Wed 4/297:00 am
SFO
- TYS
1 stop29h 33m
Frontier
Deal found 4/6![Frontier logo]()
$342
This Kiwi.com deal was found by Cheapflights users on 4/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 5/118:32 pm
TYS
- SFO
1 stop18h 15m
Multiple Airlines
Fri 5/159:56 pm
SFO
- TYS
2 stops39h 24m
Multiple Airlines
Deal found 4/6![Multiple Airlines logo]()
$343
Best flights from Knoxville to San FranciscoDiscover carefully curated flight deals from Knoxville to San Francisco that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated April 9, 2026.
Discover carefully curated flight deals from Knoxville to San Francisco that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated April 9, 2026.
This Delta deal was found by Cheapflights users on 4/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 7/311:27 am
TYS
- SFO
1 stop9h 46m
Delta
Tue 7/75:35 am
SFO
- TYS
1 stop6h 43m
Delta
Deal found 4/8![Delta logo]()
$389
This Kiwi.com deal was found by Cheapflights users on 4/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 7/18:32 pm
TYS
- SFO
1 stop18h 06m
Multiple Airlines
Sun 7/510:50 pm
SFO
- TYS
1 stop12h 07m
Multiple Airlines
Deal found 4/8![Multiple Airlines logo]()
$393
This United Airlines deal was found by Cheapflights users on 4/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 5/86:01 pm
TYS
- SFO
1 stop7h 42m
United Airlines
Mon 5/115:30 am
SFO
- TYS
1 stop8h 24m
United Airlines
Deal found 4/7![United Airlines logo]()
$514
This Alaska Airlines deal was found by Cheapflights users on 4/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Alaska Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 5/2711:29 am
TYS
- SFO
2 stops13h 02m
Alaska Airlines
Tue 6/210:30 am
SFO
- TYS
2 stops10h 26m
Alaska Airlines
Deal found 4/7![Alaska Airlines logo]()
$567
This Kiwi.com deal was found by Cheapflights users on 4/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 5/181:15 pm
TYS
- SFO
2 stops38h 08m
Multiple Airlines
Mon 5/256:00 am
SFO
- TYS
1 stop10h 24m
Multiple Airlines
Deal found 4/4![Multiple Airlines logo]()
$396
This Delta deal was found by Cheapflights users on 4/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 5/71:59 pm
TYS
- SFO
1 stop10h 05m
Delta
Wed 5/131:45 pm
SFO
- TYS
1 stop7h 11m
Delta
Deal found 4/4![Delta logo]()
$404
This Alaska Airlines deal was found by Cheapflights users on 4/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Alaska Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 4/224:09 pm
TYS
- SFO
2 stops9h 52m
Alaska Airlines
Sat 4/259:35 am
SFO
- TYS
1 stop9h 15m
Alaska Airlines
Deal found 4/8![Alaska Airlines logo]()
$574
This United Airlines deal was found by Cheapflights users on 4/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 4/157:20 pm
TYS
- SFO
1 stop8h 57m
United Airlines
Sun 4/195:00 am
SFO
- TYS
1 stop7h 06m
United Airlines
Deal found 4/8![United Airlines logo]()
$577
Last-minute flights from Knoxville to San FranciscoDiscover last-minute flight deals from Knoxville to San Francisco. Data last updated April 9, 2026 and is based on user searches.
Discover last-minute flight deals from Knoxville to San Francisco. Data last updated April 9, 2026 and is based on user searches.
This CheapOair deal was found by Cheapflights users on 4/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure CheapOair is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 4/264:28 pm
TYS
- SFO
1 stop10h 59m
Frontier
Wed 4/297:00 am
SFO
- TYS
1 stop29h 33m
Frontier
Deal found 4/6![Frontier logo]()
$342
This Kiwi.com deal was found by Cheapflights users on 4/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 4/271:43 pm
TYS
- SFO
1 stop27h 09m
Multiple Airlines
Tue 5/193:26 pm
SFO
- TYS
2 stops43h 33m
Multiple Airlines
Deal found 4/6![Multiple Airlines logo]()
$332
This Priceline deal was found by Cheapflights users on 4/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Priceline is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 4/304:28 pm
TYS
- SFO
1 stop10h 59m
Frontier
Sun 5/36:00 am
SFO
- TYS
1 stop6h 33m
Frontier
Deal found 4/5![Frontier logo]()
$230
This Kiwi.com deal was found by Cheapflights users on 4/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 5/78:00 am
TYS
- SFO
1 stop11h 30m
Multiple Airlines
Mon 5/1111:31 am
SFO
- TYS
1 stop8h 20m
Multiple Airlines
Deal found 4/8![Multiple Airlines logo]()
$336
This Kiwi.com deal was found by Cheapflights users on 4/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 5/81:15 pm
TYS
- SFO
2 stops22h 15m
Multiple Airlines
Sun 5/1010:40 pm
SFO
- TYS
1 stop21h 11m
Multiple Airlines
Deal found 4/7![Multiple Airlines logo]()
$326
This CheapOair deal was found by Cheapflights users on 4/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure CheapOair is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 5/118:32 pm
TYS
- SFO
1 stop18h 15m
Frontier
Fri 5/156:00 am
SFO
- TYS
1 stop10h 33m
Frontier
Deal found 4/6![Frontier logo]()
$322
This Kiwi.com deal was found by Cheapflights users on 4/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 5/118:32 pm
TYS
- SFO
1 stop18h 15m
Multiple Airlines
Fri 5/159:56 pm
SFO
- TYS
2 stops39h 24m
Multiple Airlines
Deal found 4/6![Multiple Airlines logo]()
$343
This Kiwi.com deal was found by Cheapflights users on 4/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 5/151:43 pm
TYS
- SFO
1 stop23h 53m
Multiple Airlines
Sun 5/1710:15 pm
SFO
- TYS
2 stops18h 18m
Multiple Airlines
Deal found 4/7![Multiple Airlines logo]()
$299
This CheapOair deal was found by Cheapflights users on 4/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure CheapOair is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 5/228:19 pm
TYS
- SFO
1 stop14h 42m
Frontier
Mon 5/256:00 am
SFO
- TYS
1 stop10h 24m
Frontier
Deal found 4/6![Frontier logo]()
$281
This Kiwi.com deal was found by Cheapflights users on 4/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 5/282:49 pm
TYS
- SFO
1 stop28h 41m
Multiple Airlines
Wed 6/310:40 pm
SFO
- TYS
2 stops35h 14m
Multiple Airlines
Deal found 4/6![Multiple Airlines logo]()
$328
This Frontier deal was found by Cheapflights users on 4/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Frontier is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 5/298:19 pm
TYS
- SFO
1 stop7h 04m
Frontier
Wed 6/36:00 am
SFO
- TYS
1 stop10h 33m
Frontier
Deal found 4/6![Frontier logo]()
$270
One-way flights from Knoxville to San FranciscoSearch for one-way flight options from Knoxville to San Francisco. Find affordable one-way fares based on user searches. Data last updated April 9, 2026.
Search for one-way flight options from Knoxville to San Francisco. Find affordable one-way fares based on user searches. Data last updated April 9, 2026.
This Trip.com deal was found by Cheapflights users on 4/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Trip.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 5/151:43 pm
TYS
- SFO
1 stop23h 53m
Multiple Airlines
Deal found 4/6![Multiple Airlines logo]()
$119
This Priceline deal was found by Cheapflights users on 4/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Priceline is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 4/234:28 pm
TYS
- SFO
1 stop10h 59m
Frontier
Deal found 4/9![Frontier logo]()
$137
This Kiwi.com deal was found by Cheapflights users on 4/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 5/118:32 pm
TYS
- SFO
1 stop18h 15m
Frontier
Deal found 4/6![Frontier logo]()
$144
This Kiwi.com deal was found by Cheapflights users on 4/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 5/87:10 am
TYS
- SFO
2 stops42h 54m
Multiple Airlines
Deal found 4/7![Multiple Airlines logo]()
$147
This Kiwi.com deal was found by Cheapflights users on 4/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 5/911:56 am
TYS
- SFO
2 stops14h 08m
Multiple Airlines
Deal found 4/7![Multiple Airlines logo]()
$153
This Kiwi.com deal was found by Cheapflights users on 4/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 5/111:15 pm
TYS
- SFO
2 stops36h 49m
Multiple Airlines
Deal found 4/6![Multiple Airlines logo]()
$157
This Kiwi.com deal was found by Cheapflights users on 4/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 5/11:15 pm
TYS
- SFO
2 stops31h 19m
Multiple Airlines
Deal found 4/4![Multiple Airlines logo]()
$164
This Kiwi.com deal was found by Cheapflights users on 4/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 5/1011:27 am
TYS
- SFO
3 stops51h 20m
Multiple Airlines
Deal found 4/6![Multiple Airlines logo]()
$170
Find flight deals from Knoxville to San Francisco
Discover tips and strategies to find the most affordable flight options for your journey from Knoxville (TYS) to San Francisco (SFO). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated April 9, 2026.
Most accurate provider | FlightHub 3 stars |
|---|---|
Most trusted provider | FlightHub 3 stars |
Round-trip from | $230 (Priceline) |
One-way from | $119 (Trip.com) |
Popular in | December |
Cheapest in | February |
Average price | $450 |
Cheapflights Fare Finder
Customize your flight search to find flights from Knoxville to San Francisco that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated April 9, 2026.
Use the filters below to find and compare flights from Knoxville to San Francisco that are best for you.
Fly from
Fly to
Route
Depart
Return
Cheapest round-trip
KnoxvilleSan Francisco
TYS - SFO
TYSSFO
Knoxville McGhee Tyson
Fri 7/3
11:27 am-6:13 pm
1 stop9h 46m
San Francisco
Tue 7/7
5:35 am-3:18 pm
1 stop6h 43m
$389
KnoxvilleSan Francisco
TYS - SFO
TYSSFO
Knoxville McGhee Tyson
Wed 7/1
8:32 pm-11:38 am
1 stop18h 06m
San Francisco
Sun 7/5
10:50 pm-1:57 pm
1 stop12h 07m
$393
KnoxvilleSan Francisco
TYS - SFO
TYSSFO
Knoxville McGhee Tyson
Mon 5/18
1:15 pm-12:23 am
2 stops38h 08m
San Francisco
Mon 5/25
6:00 am-7:24 pm
1 stop10h 24m
$396
KnoxvilleSan Francisco
TYS - SFO
TYSSFO
Knoxville McGhee Tyson
Thu 5/7
1:59 pm-9:04 pm
1 stop10h 05m
San Francisco
Wed 5/13
1:45 pm-11:56 pm
1 stop7h 11m
$404
KnoxvilleSan Francisco
TYS - SFO
TYSSFO
Knoxville McGhee Tyson
Fri 5/8
6:01 pm-10:43 pm
1 stop7h 42m
San Francisco
Mon 5/11
5:30 am-4:54 pm
1 stop8h 24m
$514
KnoxvilleSan Francisco
TYS - SFO
TYSSFO
Knoxville McGhee Tyson
Wed 5/27
11:29 am-9:31 pm
2 stops13h 02m
San Francisco
Tue 6/2
10:30 am-11:56 pm
2 stops10h 26m
$567
KnoxvilleSan Francisco
TYS - SFO
TYSSFO
Knoxville McGhee Tyson
Wed 4/22
4:09 pm-11:01 pm
2 stops9h 52m
San Francisco
Sat 4/25
9:35 am-9:50 pm
1 stop9h 15m
$574
Quickest round-trip
KnoxvilleSan Francisco
TYS - SFO
TYSSFO
Knoxville McGhee Tyson
Wed 4/15
7:20 pm-1:17 am
1 stop8h 57m
San Francisco
Sun 4/19
5:00 am-3:06 pm
1 stop7h 06m
$577
Cheapest one-way
KnoxvilleSan Francisco
TYS - SFO
TYSSFO
Knoxville McGhee Tyson
Fri 5/15
1:43 pm-10:36 am
1 stop23h 53m
$119
KnoxvilleSan Francisco
TYS - SFO
TYSSFO
Knoxville McGhee Tyson
Thu 4/23
4:28 pm-12:27 am
1 stop10h 59m
$137
Showing 1-10 of 18 resultsSorted by cheapest first
Compare providers for flights from Knoxville to San Francisco
Provider information is updated monthly. Please note that these providers often have deals for this flight, but the availability may vary on a day-by-day basis on Cheapflights.
Use the table below to compare price accuracy, trust ratings, and cancellation policies for each provider offering flight deals from Knoxville to San Francisco in April.
| Provider | Price Accuracy | Trust Score* |
|---|---|---|
| Price Accuracy1 star | Trust Score*3 stars | |
| Price Accuracy3 stars | Trust Score*3 stars |
- Most accurate provider: When it comes to deals on Knoxville-San Francisco flights, users find the pricing of FlightHub to be most consistent on Cheapflights vs. FlightHub Users can find the same prices on Knoxville-San Francisco flight deals on Cheapflights vs. FlightHub >95% of the time. Price accuracy is based on data collected from Knoxville-San Francisco flight searches over the past month and is updated monthly.
- Most trusted provider: When it comes to deals on Knoxville-San Francisco flights, Cheapflights users trust FlightHub the most. FlightHub has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for Knoxville-San Francisco flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.
Best time to book a flight from Knoxville to San Francisco
Have a flexible travel schedule? Discover the best time to fly to San Francisco from Knoxville with our price prediction graph.
TYS-SFO
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.
Cheapflights Insights
Everything you need to know about your flight from Knoxville to San Francisco
How far ahead should I book a flight from Knoxville to San Francisco?
Use this chart to determine the optimal time to book a round-trip flight from Knoxville to San Francisco. Price data was last updated on April 3, 2026.
The best time to book flights from Knoxville to San Francisco is 27 days before your desired departure date. The cost of your flight will likely increase significantly if you book two weeks in advance of your flight.
What is the cheapest month to book a flight from Knoxville to San Francisco?
Currently, June is the cheapest month in which you can book a flight from Knoxville to San Francisco (average of $187). Flying from Knoxville to San Francisco in March is currently the most expensive (average of $313). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.
How much does it cost to fly round-trip from Knoxville to San Francisco?
Reviews of airlines servicing San Francisco
Get insights into the airlines that provide service to San Francisco. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to San Francisco. Reviews last updated April 9, 2026.
Peruse reviews from past customers who have flown with Delta,United Airlines, andAmerican Airlines from Knoxville to San Francisco to help guide your decision. You can also see how each airline stacks up in terms of entertainment options, comfort, food, crew/service, and boarding process.
Boarding
8.1
Comfort
7.9
Entertainment
7.8
Overall
7.9
Crew
8.5
Food
7.2
Reviews
1 / 20
10.0
ExcellentAaron,Oct 2024
TUS - LAX
Boarding
8.1
Comfort
7.9
Entertainment
7.8
Overall
7.9
Crew
8.5
Food
7.2
Reviews
1 / 20
10.0
ExcellentAaron,Oct 2024
TUS - LAX
Boarding
8.1
Comfort
7.9
Entertainment
7.8
Overall
7.9
Crew
8.5
Food
7.2
Reviews
1 / 20
10.0
ExcellentAaron,Oct 2024
TUS - LAX
Boarding
8.1
Comfort
7.9
Entertainment
7.8
Overall
7.9
Crew
8.5
Food
7.2
Reviews
1 / 20
10.0
ExcellentAaron,Oct 2024
TUS - LAX
Boarding
8.1
Comfort
7.9
Entertainment
7.8
Overall
7.9
Crew
8.5
Food
7.2
Reviews
1 / 20
10.0
ExcellentAaron,Oct 2024
TUS - LAX
Related info for your journey
Find useful and relevant information for your journey from Knoxville to San Francisco. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.
Traveling to a place near San Francisco?
Book flights to San Francisco if you plan to visit one of these locationsSouth San Francisco
Santa Cruz
Santa Clara
Livermore
Roseville
Rancho Cordova
San Bruno
Watsonville
San Ramon
Union City
Emeryville
Vacaville
San Carlos
Redwood City
Sunnyvale
Turlock
San Lorenzo
Davis
Manteca
Elk Grove
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Knoxville and San Francisco flights
Browse other Knoxville and San Francisco flight options. Last updated on April 9, 2026.
Other flights from Knoxville
Browse through other flights departing from Knoxville. Flights are based on user searches made on Cheapflights and were last updated on April 9, 2026.
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Top 4 airlines flying from Knoxville to San Francisco
Discover the top 4 airlines that operate flights from Knoxville to San Francisco. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated April 9, 2026.
| Airline | Cheapest | Average | Flexibility | On-time |
|---|---|---|---|---|
| Cheapest$184 | Average$254 | FlexibilityNo cancel fee | On-time62% | |
| Cheapest$276 | Average$450 | FlexibilityNo cancel fee | On-timeN/A | |
| Cheapest$308 | Average$468 | FlexibilityNo cancel fee | On-time69% | |
| Cheapest$308 | Average$430 | FlexibilityNo cancel fee | On-time71% |