San Francisco

$127+ Cheap flights from Knoxville to San Francisco (TYS - SFO)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 4/22. Fares are subject to change and may not be available on all flights or dates of travel.
TYS — SFO
Apr 23 — Apr 301
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Cheap flight deals from Knoxville to San Francisco

Cheapest flights from Knoxville to San Francisco
Explore the most affordable flight options available from Knoxville to San Francisco. Find the lowest fares from popular airlines and budget airlines, with prices last updated on March 24, 2026.

This CheapOair deal was found by Cheapflights users on 3/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure CheapOair is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 4/164:28 pm
TYS
-
SFO
1 stop19h 45m
Frontier
Sun 4/196:00 am
SFO
-
TYS
1 stop6h 33m
Frontier
Deal found 3/20$221
This American Airlines deal was found by Cheapflights users on 3/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 5/57:00 am
TYS
-
SFO
1 stop8h 32m
American Airlines
Tue 5/129:08 am
SFO
-
TYS
1 stop10h 04m
American Airlines
Deal found 3/24$253
This CheapOair deal was found by Cheapflights users on 3/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure CheapOair is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 5/228:32 pm
TYS
-
SFO
1 stop14h 29m
Frontier
Mon 5/258:56 am
SFO
-
TYS
1 stop7h 37m
Frontier
Deal found 3/24$261
This United Airlines deal was found by Cheapflights users on 3/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 4/287:05 am
TYS
-
SFO
1 stop8h 13m
United Airlines
Sat 5/211:10 am
SFO
-
TYS
1 stop8h 13m
United Airlines
Deal found 3/24$278
This United Airlines deal was found by Cheapflights users on 3/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 5/27:00 am
TYS
-
SFO
1 stop7h 24m
United Airlines
Sat 5/95:30 am
SFO
-
TYS
1 stop8h 24m
United Airlines
Deal found 3/24$298
This CheapOair deal was found by Cheapflights users on 3/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure CheapOair is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 6/18:32 pm
TYS
-
SFO
1 stop18h 10m
Frontier
Tue 6/912:33 pm
SFO
-
TYS
1 stop28h 04m
Frontier
Deal found 3/24$301
This Kiwi.com deal was found by Cheapflights users on 3/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 5/151:15 pm
TYS
-
SFO
2 stops36h 49m
Multiple Airlines
Wed 5/2012:52 pm
SFO
-
TYS
1 stop22h 07m
Multiple Airlines
Deal found 3/22$305
This Southwest deal was found by Cheapflights users on 3/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 5/212:20 pm
TYS
-
SFO
2 stops12h 00m
Southwest
Sat 5/910:10 am
SFO
-
TYS
1 stop6h 25m
Southwest
Deal found 3/24$308
This Expedia deal was found by Cheapflights users on 3/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Expedia is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 4/64:20 pm
TYS
-
SFO
1 stop11h 08m
Frontier
Fri 4/106:00 am
SFO
-
TYS
1 stop6h 28m
Frontier
Deal found 3/21$310
This CheapOair deal was found by Cheapflights users on 3/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure CheapOair is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 4/34:20 pm
TYS
-
SFO
1 stop11h 03m
Frontier
Sun 4/59:00 pm
SFO
-
TYS
1 stop15h 28m
Frontier
Deal found 3/23$316
This Kiwi.com deal was found by Cheapflights users on 3/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 5/78:00 am
TYS
-
SFO
1 stop11h 30m
Multiple Airlines
Sun 5/105:25 pm
SFO
-
TYS
2 stops21h 05m
Multiple Airlines
Deal found 3/23$324

Find flight deals from Knoxville to San Francisco

Discover tips and strategies to find the most affordable flight options for your journey from Knoxville (TYS) to San Francisco (SFO). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated March 24, 2026.

Most accurate provider

FlightHub
3 stars

Most trusted provider

FlightHub
3 stars

Round-trip from

$221
(CheapOair)

One-way from

$127
(United Airlines)

Popular in

December

Cheapest in

February

Average price

$471
Provider with most accurate pricing for Knoxville McGhee Tyson-San Francisco flight deals.
Provider most trusted by Cheapflights users for Knoxville McGhee Tyson-San Francisco flights.
From Knoxville McGhee Tyson to San Francisco
One-way flight from Knoxville McGhee Tyson to San Francisco
Highest demand for flights based on searches. 8% potential increase in price ($42 potential increase over avg. RT price).
Cheapest flight prices on average. 1% potential price decrease ($8 potential savings vs. average RT price).
Average for round-trip flights in March 2026

Cheapflights Fare Finder

 
Customize your flight search to find flights from Knoxville to San Francisco that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated March 24, 2026.
Use the filters below to find and compare flights from Knoxville to San Francisco that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Cheapest round-trip

KnoxvilleSan Francisco

TYS - SFO

TYSSFO

Knoxville McGhee Tyson

Wed 5/6

7:05 am-3:20 pm

2 stops11h 15m

San Francisco

Tue 5/12

5:25 am-7:40 pm

2 stops11h 15m

$332

KnoxvilleSan Francisco

TYS - SFO

TYSSFO

Knoxville McGhee Tyson

Sat 4/25

6:40 am-4:20 pm

1 stop12h 40m

San Francisco

Sat 5/2

5:40 am-7:35 pm

1 stop10h 55m

$358

KnoxvilleSan Francisco

TYS - SFO

TYSSFO

Knoxville McGhee Tyson

Fri 5/1

7:00 am-11:24 am

1 stop7h 24m

San Francisco

Sun 5/3

5:30 am-4:59 pm

1 stop8h 29m

$384

KnoxvilleSan Francisco

TYS - SFO

TYSSFO

Knoxville McGhee Tyson

Sat 4/25

5:15 pm-10:30 pm

1 stop8h 15m

San Francisco

Sat 5/2

5:30 am-4:54 pm

1 stop8h 24m

$384
Quickest round-trip

KnoxvilleSan Francisco

TYS - SFO

TYSSFO

Knoxville McGhee Tyson

Tue 4/28

7:00 am-12:03 pm

1 stop8h 03m

San Francisco

Tue 5/5

12:00 pm-10:23 pm

1 stop7h 23m

$389

KnoxvilleSan Francisco

TYS - SFO

TYSSFO

Knoxville McGhee Tyson

Wed 5/13

7:18 pm-1:16 am

1 stop8h 58m

San Francisco

Sat 5/16

12:00 pm-10:23 pm

1 stop7h 23m

$389

KnoxvilleSan Francisco

TYS - SFO

TYSSFO

Knoxville McGhee Tyson

Fri 4/24

7:00 am-1:12 pm

1 stop9h 12m

San Francisco

Tue 4/28

11:52 pm-10:08 am

1 stop7h 16m

$414

KnoxvilleSan Francisco

TYS - SFO

TYSSFO

Knoxville McGhee Tyson

Fri 5/15

6:54 pm-11:54 pm

1 stop8h 00m

San Francisco

Wed 5/20

7:00 am-6:13 pm

1 stop8h 13m

$457

KnoxvilleSan Francisco

TYS - SFO

TYSSFO

Knoxville McGhee Tyson

Fri 4/24

4:09 pm-11:01 pm

2 stops9h 52m

San Francisco

Tue 4/28

10:10 am-11:56 pm

2 stops10h 46m

$479

KnoxvilleSan Francisco

TYS - SFO

TYSSFO

Knoxville McGhee Tyson

Wed 4/15

7:05 am-12:18 pm

1 stop8h 13m

San Francisco

Sat 4/18

7:00 am-7:56 pm

1 stop9h 56m

$489

Flights are sorted by cheapest round-trip flights first.

Deals found on 3/24

Showing 1-10 of 18 resultsSorted by cheapest first
1
2

Compare providers for flights from Knoxville to San Francisco

Provider information is updated monthly. Please note that these providers often have deals for this flight, but the availability may vary on a day-by-day basis on Cheapflights.
Use the table below to compare price accuracy, trust ratings, and cancellation policies for each provider offering flight deals from Knoxville to San Francisco in March.
ProviderPrice AccuracyTrust Score*
ExpediaPrice Accuracy1 starTrust Score*3 stars
FlightHubPrice Accuracy3 starsTrust Score*3 stars

*The Trust Score is based on feedback from users after their booking experience. It measures overall satisfaction, helping us identify issues like hidden fees, problems during the ticketing process, and the quality of customer service. This score is our best indicator of the provider's quality and reliability.

  • Most accurate provider: When it comes to deals on Knoxville-San Francisco flights, users find the pricing of FlightHub to be most consistent on Cheapflights vs. FlightHub Users can find the same prices on Knoxville-San Francisco flight deals on Cheapflights vs. FlightHub >95% of the time. Price accuracy is based on data collected from Knoxville-San Francisco flight searches over the past month and is updated monthly.
  • Most trusted provider: When it comes to deals on Knoxville-San Francisco flights, Cheapflights users trust FlightHub the most. FlightHub has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for Knoxville-San Francisco flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.

Best time to book a flight from Knoxville to San Francisco

Have a flexible travel schedule? Discover the best time to fly to San Francisco from Knoxville with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Knoxville to San Francisco

How far ahead should I book a flight from Knoxville to San Francisco?

Use this chart to determine the optimal time to book a round-trip flight from Knoxville to San Francisco. Price data was last updated on March 13, 2026.

The best time to book flights from Knoxville to San Francisco is 27 days before your desired departure date. The cost of your flight will likely increase significantly if you book two weeks in advance of your flight.

What is the cheapest month to book a flight from Knoxville to San Francisco?

Currently, December is the cheapest month in which you can book a flight from Knoxville to San Francisco (average of $194). Flying from Knoxville to San Francisco in March is currently the most expensive (average of $324). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

Reviews of airlines servicing San Francisco

Get insights into the airlines that provide service to San Francisco. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to San Francisco. Reviews last updated March 24, 2026.
Peruse reviews from past customers who have flown with Delta,United Airlines, andAmerican Airlines from Knoxville to San Francisco to help guide your decision. You can also see how each airline stacks up in terms of entertainment options, comfort, food, crew/service, and boarding process.

Comfort

7.9

Food

7.2

Boarding

8.1

Entertainment

7.8

Overall

7.9

Crew

8.5

Reviews

1 / 20
10.0
Excellent

Aaron,Oct 2024

TUS - LAX

Delta has consistently been the best U.S. airline for my travels and this flight was no exception

Comfort

7.9

Food

7.2

Boarding

8.1

Entertainment

7.8

Overall

7.9

Crew

8.5

Reviews

1 / 20
10.0
Excellent

Aaron,Oct 2024

TUS - LAX

Delta has consistently been the best U.S. airline for my travels and this flight was no exception

Comfort

7.9

Food

7.2

Boarding

8.1

Entertainment

7.8

Overall

7.9

Crew

8.5

Reviews

1 / 20
10.0
Excellent

Aaron,Oct 2024

TUS - LAX

Delta has consistently been the best U.S. airline for my travels and this flight was no exception

Comfort

7.9

Food

7.2

Boarding

8.1

Entertainment

7.8

Overall

7.9

Crew

8.5

Reviews

1 / 20
10.0
Excellent

Aaron,Oct 2024

TUS - LAX

Delta has consistently been the best U.S. airline for my travels and this flight was no exception

Comfort

7.9

Food

7.2

Boarding

8.1

Entertainment

7.8

Overall

7.9

Crew

8.5

Reviews

1 / 20
10.0
Excellent

Aaron,Oct 2024

TUS - LAX

Delta has consistently been the best U.S. airline for my travels and this flight was no exception

Related info for your journey

Find useful and relevant information for your journey from Knoxville to San Francisco. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.
  • How long is the flight from Knoxville to San Francisco?

    Departing from Knoxville to San Francisco will take you 7h 24m. The distance between Knoxville and San Francisco is about 2114 mi. Both multi-stop and nonstop flights can be found to your destination and back.

  • What are the cheapest airlines flying from Knoxville to San Francisco round-trip?

    Flying on Frontier is currently your cheapest option to San Francisco, with prices starting at $184. Additional round-trip tickets that might be worth considering are offered by Delta and American Airlines, with the lowest prices starting at $276 and $308, respectively. Frontier is priced at 57% lower than the current average price of a flight leaving 3 months from now.

  • What are the cheapest airlines to fly from Knoxville to San Francisco one-way?

    The cheapest airline one-way is Frontier, with whom users have recently found tickets for as low as $91. However, be on the lookout for offers from American Airlines and United Airlines, as they are both options that can get you from Knoxville to San Francisco for a low price.

  • Can I find deals for flights from Knoxville to San Francisco that include hotel bookings?

    Yes. In addition to deals on Knoxville to San Francisco flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Knoxville to San Francisco?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Knoxville to San Francisco.

  • Can I find deals for business class flights from Knoxville to San Francisco?

    Yes. Cheapflights offers flight deals from Knoxville to San Francisco by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Knoxville to San Francisco?

    Currently, December is the cheapest month in which you can book a flight from Knoxville to San Francisco (average of $194). Flying from Knoxville to San Francisco in March is currently the most expensive (average of $324). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Traveling to a place near San Francisco?

Book flights to San Francisco if you plan to visit one of these locations
South San Francisco
Santa Cruz
Santa Clara
Livermore
Roseville
Rancho Cordova
San Bruno
Watsonville
San Ramon
Sunnyvale
Vacaville
San Carlos
Turlock
Redwood City
San Lorenzo
Davis
Manteca
Union City
Elk Grove
Rohnert Park

Browse thousands of different options on Cheapflights for your next trip

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Alternative routes for Knoxville to San Francisco

See prices for flight routes from nearby airports that may be better suited for you.

Top 4 airlines flying from Knoxville to San Francisco

Discover the top 4 airlines that operate flights from Knoxville to San Francisco. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated March 24, 2026.
AirlineCheapestAverageFlexibilityOn-time
FrontierCheapest$184Average$254FlexibilityNo cancel feeOn-time62%
DeltaCheapest$276Average$452FlexibilityNo cancel feeOn-timeN/A
United AirlinesCheapest$308Average$495FlexibilityNo cancel feeOn-time69%
American AirlinesCheapest$308Average$431FlexibilityNo cancel feeOn-time71%

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