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$155+ Cheap flights from Knoxville to San Francisco (TYS - SFO)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 9/9. Fares are subject to change and may not be available on all flights or dates of travel.
TYS — SFO
jun. 17 — jun. 241
mar. 6/17
mar. 6/24
1 adult, Economy
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Cheapflights Tip: The best prices from Knoxville McGhee Tyson to San Francisco are usually found in September or January, booked 89 days in advance, depart on a Tuesday or Wednesday and return on a Tuesday

Cheap flight deals from Knoxville to San Francisco

Discover tips and strategies to find the most affordable flight options for your journey from Knoxville (TYS) to San Francisco (SFO). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated junio 12, 2025.

Round-trip from

$309
(United Airlines)

One-way from

$155
(Delta)

Popular in

December

Cheapest in

September

Average price

$456
From Knoxville McGhee Tyson to San Francisco
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One-way flight from Knoxville McGhee Tyson to San Francisco
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Highest demand for flights based on searches. 1% potential increase in price ($7 potential increase over avg. RT price).
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Cheapest flight prices on average. 1% potential price decrease ($6 potential savings vs. average RT price).
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Average for round-trip flights in June 2025
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Find flight deals from Knoxville to San Francisco

Cheapest flights from Knoxville to San Francisco
Explore the most affordable flight options available from Knoxville to San Francisco. Find the lowest fares from popular airlines and budget airlines, with prices last updated on junio 12, 2025.

This United Airlines deal was found by Cheapflights users on 6/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
mié. 9/310:54 amTYS - SFO
1 stop7h 36mUnited Airlines
sáb. 9/67:00 amSFO - TYS
1 stop7h 00mUnited Airlines
Deal found 6/10$309
This American Airlines deal was found by Cheapflights users on 6/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
vie. 7/42:48 pmTYS - SFO
2 stops9h 10mAmerican Airlines
lun. 7/712:55 amSFO - TYS
1 stop7h 46mAmerican Airlines
Deal found 6/10$314
This Frontier deal was found by Cheapflights users on 6/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Frontier is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
jue. 8/75:25 pmTYS - SFO
2 stops17h 16mFrontier
dom. 8/106:37 amSFO - TYS
1 stop6h 52mFrontier
Deal found 6/12$363
This Delta deal was found by Cheapflights users on 6/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
jue. 10/96:05 pmTYS - SFO
1 stop8h 44mDelta
sáb. 10/188:00 pmSFO - TYS
2 stops10h 11mDelta
Deal found 6/10$402
This Mytrip deal was found by Cheapflights users on 6/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
lun. 6/2310:59 amTYS - SFO
1 stop27h 09mMultiple Airlines
jue. 6/2611:59 pmSFO - TYS
1 stop13h 12mMultiple Airlines
Deal found 6/10$434
This Alaska Airlines deal was found by Cheapflights users on 6/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Alaska Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
jue. 8/72:16 pmTYS - SFO
2 stops12h 34mAlaska Airlines
dom. 8/107:20 amSFO - TYS
2 stops13h 33mAlaska Airlines
Deal found 6/12$847

Cheapflights Fare Finder

Customize your flight search to find flights from Knoxville to San Francisco that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated junio 12, 2025.
Use the filters below to find and compare flights from Knoxville to San Francisco that are best for you.

Fly from

Knoxville

Fly to

San Francisco

Route

Depart

Return

Price

KnoxvilleSan Francisco

TYS - SFO

TYSSFO

Knoxville McGhee Tyson

mié. 9/3

10:54 am-3:30 pm

1 stop7h 36m

San Francisco

sáb. 9/6

7:00 am-5:00 pm

1 stop7h 00m

$309

KnoxvilleSan Francisco

TYS - SFO

TYSSFO

Knoxville McGhee Tyson

vie. 7/4

2:48 pm-8:58 pm

2 stops9h 10m

San Francisco

lun. 7/7

12:55 am-11:41 am

1 stop7h 46m

$314

KnoxvilleSan Francisco

TYS - SFO

TYSSFO

Knoxville McGhee Tyson

jue. 8/7

5:25 pm-7:41 am

2 stops17h 16m

San Francisco

dom. 8/10

6:37 am-4:29 pm

1 stop6h 52m

$363

KnoxvilleSan Francisco

TYS - SFO

TYSSFO

Knoxville McGhee Tyson

mié. 6/25

7:46 am-2:34 pm

1 stop9h 48m

San Francisco

jue. 7/10

9:35 pm-9:50 am

1 stop9h 15m

$384

KnoxvilleSan Francisco

TYS - SFO

TYSSFO

Knoxville McGhee Tyson

lun. 6/23

10:59 am-11:08 am

1 stop27h 09m

San Francisco

jue. 6/26

11:59 pm-4:11 pm

1 stop13h 12m

$434

KnoxvilleSan Francisco

TYS - SFO

TYSSFO

Knoxville McGhee Tyson

jue. 8/7

2:16 pm-11:50 pm

2 stops12h 34m

San Francisco

dom. 8/10

7:20 am-11:53 pm

2 stops13h 33m

$847

KnoxvilleSan Francisco

TYS - SFO

TYSSFO

Knoxville McGhee Tyson

mar. 9/9

1:53 pm-6:52 pm

1 stop7h 59m

$155

KnoxvilleSan Francisco

TYS - SFO

TYSSFO

Knoxville McGhee Tyson

mié. 7/9

7:00 am-11:29 am

1 stop7h 29m

$205

KnoxvilleSan Francisco

TYS - SFO

TYSSFO

Knoxville McGhee Tyson

lun. 7/14

11:01 am-11:05 am

1 stop27h 04m

$222

KnoxvilleSan Francisco

TYS - SFO

TYSSFO

Knoxville McGhee Tyson

lun. 7/7

4:15 pm-10:47 pm

1 stop9h 32m

$370

Flights are sorted by cheapest round-trip flights first.

Deals found on 6/11

Best time to book a flight from Knoxville to San Francisco

Have a flexible travel schedule? Discover the best time to fly to San Francisco from Knoxville with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Knoxville to San Francisco

How far ahead should I book a flight from Knoxville to San Francisco?

Use this chart to determine the optimal time to book a round-trip flight from Knoxville to San Francisco. Price data was last updated on June 9, 2025.

The best time to book flights from Knoxville to San Francisco is 89 days before your desired departure date. The cost of your flight will likely increase significantly if you book two weeks in advance of your flight.

What is the cheapest month to book a flight from Knoxville to San Francisco?

Currently, January is the cheapest month in which you can book a flight from Knoxville to San Francisco (average of $276). Flying from Knoxville to San Francisco in June is currently the most expensive (average of $364). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from TYS to SFO?

Find hourly flight availability from Knoxville to San Francisco. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated junio 12, 2025.

One of the essential ways to save on airfare from Knoxville to San Francisco is to remain as flexible as possible. Flights that are in the morning tend to be the most expensive. A flight in the evening could potentially save you up to 30% on airfare.

What is the cheapest day to fly from Knoxville to San Francisco?

Use this chart to determine the cheapest time to fly round-trip from Knoxville to San Francisco. Price data was last updated on December 16, 2024.

Travelers seeking maximum savings on their Knoxville to San Francisco flight should consider departing on Sunday afternoons when fares are most often at their lowest. Sunday evenings flights should be avoided if possible as fares are typically the most expensive at this time.

Rainfall in San Francisco by month

Plan your trip to San Francisco by taking into account the average rainfall totals by month.

In terms of precipitation, rainfall in San Francisco ranges from 0.0 - 4.4 inches per month. January is typically the wettest month, when rainfall can reach 4.4 in. July is typically the driest time to visit San Francisco when rainfall is around 0.0 in.

Temperature in San Francisco by month

Plan your trip to San Francisco by taking into account the average temperature totals by month.

If weather is an important factor for your trip to San Francisco, use this chart to help with planning. For those seeking warmer temperatures, September is the ideal time of year to visit, when temperatures reach an average of 62.6 F. Travelers looking to avoid the cold should look outside of January, when temperatures are typically at their lowest (around 51.8 F).

Reviews of airlines servicing San Francisco

Get insights into the airlines that provide service to San Francisco. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to San Francisco. Reviews last updated junio 12, 2025.
Read reviews from past customers who have flown Alaska Airlines, Delta and United Airlines from Knoxville to San Francisco. You can also see how each airline stacks up in terms of entertainment options, comfort, food, crew/service, and boarding process.
Alaska Airlines
8.0
Very good
10,000 reviews

Boarding

8.1

Comfort

7.8

Food

7.1

Overall

8.0

Entertainment

7.1

Crew

8.5

Reviews

1 / 20
10.0
Excellent

James,Apr 2025

LAX - SFO

Good flight except the uncontrollable cold air from the ceiling.
Alaska Airlines
8.0
Very good
10,000 reviews
Alaska Airlines
8.0
Very good
10,000 reviews

Boarding

8.1

Comfort

7.8

Food

7.1

Overall

8.0

Entertainment

7.1

Crew

8.5

Reviews

1 / 20
10.0
Excellent

James,Apr 2025

LAX - SFO

Good flight except the uncontrollable cold air from the ceiling.
Delta
8.0
Very good
7,950 reviews
Alaska Airlines
8.0
Very good
10,000 reviews

Boarding

8.1

Comfort

7.8

Food

7.1

Overall

8.0

Entertainment

7.1

Crew

8.5

Reviews

1 / 20
10.0
Excellent

James,Apr 2025

LAX - SFO

Good flight except the uncontrollable cold air from the ceiling.
United Airlines
7.4
Good
8,790 reviews
Alaska Airlines
8.0
Very good
10,000 reviews

Boarding

8.1

Comfort

7.8

Food

7.1

Overall

8.0

Entertainment

7.1

Crew

8.5

Reviews

1 / 20
10.0
Excellent

James,Apr 2025

LAX - SFO

Good flight except the uncontrollable cold air from the ceiling.
American Airlines
7.2
Good
10,000 reviews
Alaska Airlines
8.0
Very good
10,000 reviews

Boarding

8.1

Comfort

7.8

Food

7.1

Overall

8.0

Entertainment

7.1

Crew

8.5

Reviews

1 / 20
10.0
Excellent

James,Apr 2025

LAX - SFO

Good flight except the uncontrollable cold air from the ceiling.
Frontier
5.9
Fair
3,295 reviews
Alaska Airlines
8.0
Very good
10,000 reviews

Boarding

8.1

Comfort

7.8

Food

7.1

Overall

8.0

Entertainment

7.1

Crew

8.5

Reviews

1 / 20
10.0
Excellent

James,Apr 2025

LAX - SFO

Good flight except the uncontrollable cold air from the ceiling.

Related info for your journey

Find useful and relevant information for your journey from Knoxville to San Francisco. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What are the cheapest airlines flying from Knoxville to San Francisco round-trip?

    Flying on United Airlines is currently your cheapest option to San Francisco, with prices starting at $309. Additional round-trip tickets that might be worth considering are offered by American Airlines and Frontier, with the lowest prices starting at $314 and $363, respectively. United Airlines is priced at 26% lower than the current average price of a flight leaving 3 months from now.

  • What are the cheapest airlines to fly from Knoxville to San Francisco one-way?

    The cheapest airline one-way is Delta, with whom users have recently found tickets for as low as $155. However, be on the lookout for offers from United Airlines and American Airlines, as they are both options that can get you from Knoxville to San Francisco for a low price.

  • Can I find deals for flights from Knoxville to San Francisco that include hotel bookings?

    Yes. In addition to deals on Knoxville to San Francisco flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Knoxville to San Francisco?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Knoxville to San Francisco.

  • Can I find deals for business class flights from Knoxville to San Francisco?

    Yes. Cheapflights offers flight deals from Knoxville to San Francisco by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Knoxville to San Francisco?

    Currently, January is the cheapest month in which you can book a flight from Knoxville to San Francisco (average of $276). Flying from Knoxville to San Francisco in June is currently the most expensive (average of $364). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Traveling to a place near Knoxville?

Book flights to Knoxville if you plan to visit one of these locations
Roseville
Mountain View
South San Francisco
Livermore
Turlock
Santa Cruz
Manteca
Fairfield
Watsonville
Antioch
Hollister
Milpitas
Newark
Hayward
Alameda
Sunnyvale
Daly City
Union City
Campbell
Capitola

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Top 4 airlines flying from Knoxville to San Francisco

Discover the top 4 airlines that operate flights from Knoxville to San Francisco. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated junio 12, 2025.
AirlineCheapestAverageFlexibilityOn-time
FrontierCheapest$155Average$190FlexibilityNo cancel feeOn-time62%
United AirlinesCheapest$248Average$507FlexibilityNo cancel feeOn-time69%
American AirlinesCheapest$305Average$422FlexibilityNo cancel feeOn-time71%
DeltaCheapest$308Average$418FlexibilityNo cancel feeOn-timeN/A

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