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$123+ Cheap flights from Knoxville to San Francisco (TYS - SFO)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 3/25. Fares are subject to change and may not be available on all flights or dates of travel.
TYS — SFO
Feb 7 — Feb 141
Sat 2/7
Sat 2/14
1 adult, Economy
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Cheap flight deals from Knoxville to San Francisco

Discover tips and strategies to find the most affordable flight options for your journey from Knoxville (TYS) to San Francisco (SFO). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated January 8, 2026.

Most accurate provider

eDreams
3 stars

Most trusted provider

eDreams
3 stars

Round-trip from

$177
(Frontier)

One-way from

$123
(American Airlines)

Popular in

December

Cheapest in

February

Average price

$403
Provider with most accurate pricing for Knoxville McGhee Tyson-San Francisco flight deals.
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Provider most trusted by Cheapflights users for Knoxville McGhee Tyson-San Francisco flights.
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From Knoxville McGhee Tyson to San Francisco
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One-way flight from Knoxville McGhee Tyson to San Francisco
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Highest demand for flights based on searches. 7% potential increase in price ($35 potential increase over avg. RT price).
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Cheapest flight prices on average. 1% potential price decrease ($8 potential savings vs. average RT price).
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Average for round-trip flights in January 2026
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Find flight deals from Knoxville to San Francisco

Cheapest flights from Knoxville to San Francisco
Explore the most affordable flight options available from Knoxville to San Francisco. Find the lowest fares from popular airlines and budget airlines, with prices last updated on January 8, 2026.

This Frontier deal was found by Cheapflights users on 1/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Frontier is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 2/24:30 pmTYS - SFO
1 stop10h 58mFrontier
Fri 2/66:15 amSFO - TYS
1 stop6h 15mFrontier
Deal found 1/6$177
This United Airlines deal was found by Cheapflights users on 1/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 2/411:40 amTYS - SFO
1 stop8h 10mUnited Airlines
Tue 2/1711:59 pmSFO - TYS
1 stop7h 20mUnited Airlines
Deal found 1/7$245
This American Airlines deal was found by Cheapflights users on 1/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 2/412:21 pmTYS - SFO
2 stops10h 49mAmerican Airlines
Tue 2/176:00 amSFO - TYS
1 stop7h 31mAmerican Airlines
Deal found 1/7$250
This Kiwi.com deal was found by Cheapflights users on 1/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 3/1110:00 amTYS - SFO
1 stop14h 19mMultiple Airlines
Wed 3/186:00 amSFO - TYS
2 stops32h 22mMultiple Airlines
Deal found 1/8$272
This Kiwi.com deal was found by Cheapflights users on 1/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 3/1110:00 amTYS - SFO
1 stop14h 19mMultiple Airlines
Sat 3/1410:38 pmSFO - TYS
2 stops37h 47mMultiple Airlines
Deal found 1/7$279
This United Airlines deal was found by Cheapflights users on 1/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 2/137:25 pmTYS - SFO
1 stop9h 03mUnited Airlines
Tue 2/1711:59 pmSFO - TYS
1 stop7h 20mUnited Airlines
Deal found 1/8$287
This Kiwi.com deal was found by Cheapflights users on 1/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 2/138:12 pmTYS - SFO
1 stop14h 51mMultiple Airlines
Tue 2/177:15 pmSFO - TYS
2 stops16h 47mMultiple Airlines
Deal found 1/7$289
This Kiwi.com deal was found by Cheapflights users on 1/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 2/268:30 amTYS - SFO
1 stop12h 28mMultiple Airlines
Sun 3/19:16 pmSFO - TYS
2 stops19h 02mMultiple Airlines
Deal found 1/7$291
This United Airlines deal was found by Cheapflights users on 1/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 2/31:59 pmTYS - SFO
1 stop8h 10mUnited Airlines
Mon 2/99:20 pmSFO - TYS
1 stop10h 37mUnited Airlines
Deal found 1/6$301

Cheapflights Fare Finder

 
Customize your flight search to find flights from Knoxville to San Francisco that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated January 8, 2026.
Use the filters below to find and compare flights from Knoxville to San Francisco that are best for you.

Fly from

Knoxville

Fly to

San Francisco

Route

Depart

Return

Price

KnoxvilleSan Francisco

TYS - SFO

TYSSFO

Knoxville McGhee Tyson

Wed 2/4

11:40 am-4:50 pm

1 stop8h 10m

San Francisco

Tue 2/17

11:59 pm-10:19 am

1 stop7h 20m

$245

KnoxvilleSan Francisco

TYS - SFO

TYSSFO

Knoxville McGhee Tyson

Fri 2/13

2:49 pm-8:56 pm

1 stop9h 07m

San Francisco

Tue 2/17

11:35 pm-11:31 am

1 stop8h 56m

$287

KnoxvilleSan Francisco

TYS - SFO

TYSSFO

Knoxville McGhee Tyson

Fri 2/13

8:12 pm-8:03 am

1 stop14h 51m

San Francisco

Tue 2/17

7:15 pm-3:02 pm

2 stops16h 47m

$289

KnoxvilleSan Francisco

TYS - SFO

TYSSFO

Knoxville McGhee Tyson

Thu 2/26

8:30 am-5:58 pm

1 stop12h 28m

San Francisco

Sun 3/1

9:16 pm-7:18 pm

2 stops19h 02m

$291

KnoxvilleSan Francisco

TYS - SFO

TYSSFO

Knoxville McGhee Tyson

Tue 3/17

6:35 am-1:00 pm

2 stops9h 25m

San Francisco

Mon 3/23

10:55 pm-11:50 am

1 stop9h 55m

$311

KnoxvilleSan Francisco

TYS - SFO

TYSSFO

Knoxville McGhee Tyson

Sat 4/25

7:46 am-2:55 pm

1 stop10h 09m

San Francisco

Mon 4/27

6:00 am-4:49 pm

1 stop7h 49m

$315

KnoxvilleSan Francisco

TYS - SFO

TYSSFO

Knoxville McGhee Tyson

Fri 4/24

5:30 pm-10:25 pm

1 stop7h 55m

San Francisco

Mon 4/27

10:55 pm-10:06 am

1 stop8h 11m

$315

KnoxvilleSan Francisco

TYS - SFO

TYSSFO

Knoxville McGhee Tyson

Sat 1/31

3:00 pm-8:25 pm

1 stop8h 25m

San Francisco

Mon 2/2

6:00 am-3:46 pm

1 stop6h 46m

$315

KnoxvilleSan Francisco

TYS - SFO

TYSSFO

Knoxville McGhee Tyson

Wed 3/25

7:02 am-12:17 pm

1 stop8h 15m

$123

KnoxvilleSan Francisco

TYS - SFO

TYSSFO

Knoxville McGhee Tyson

Wed 5/6

8:45 am-3:17 pm

1 stop9h 32m

$123

Flights are sorted by cheapest round-trip flights first.

Deals found on 1/7

Showing 1-10 of 18 results
1
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Compare providers for flights from Knoxville to San Francisco

Provider information is updated monthly. Please note that these providers often have deals for this flight, but the availability may vary on a day-by-day basis on Cheapflights.
Use the table below to compare price accuracy, trust ratings, and cancellation policies for each provider offering flight deals from Knoxville to San Francisco in January.
ProviderPrice AccuracyTrust Score*
ExpediaPrice Accuracy2 starsTrust Score*3 stars
FlightHubPrice Accuracy3 starsTrust Score*1 star
eDreamsPrice Accuracy3 starsTrust Score*3 stars

*The Trust Score is based on feedback from users after their booking experience. It measures overall satisfaction, helping us identify issues like hidden fees, problems during the ticketing process, and the quality of customer service. This score is our best indicator of the provider's quality and reliability.

  • Most accurate provider: When it comes to deals on Knoxville-San Francisco flights, users find the pricing of eDreams to be most consistent on Cheapflights vs. eDreams Users can find the same prices on Knoxville-San Francisco flight deals on Cheapflights vs. eDreams >95% of the time. Price accuracy is based on data collected from Knoxville-San Francisco flight searches over the past month and is updated monthly.
  • Most trusted provider: When it comes to deals on Knoxville-San Francisco flights, Cheapflights users trust eDreams the most. eDreams has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for Knoxville-San Francisco flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.

Best time to book a flight from Knoxville to San Francisco

Have a flexible travel schedule? Discover the best time to fly to San Francisco from Knoxville with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Knoxville to San Francisco

How far ahead should I book a flight from Knoxville to San Francisco?

Use this chart to determine the optimal time to book a round-trip flight from Knoxville to San Francisco. Price data was last updated on January 2, 2026.

The best time to book flights from Knoxville to San Francisco is 27 days before your desired departure date. The cost of your flight will likely increase significantly if you book two weeks in advance of your flight.

What is the cheapest month to book a flight from Knoxville to San Francisco?

Currently, June is the cheapest month in which you can book a flight from Knoxville to San Francisco (average of $194). Flying from Knoxville to San Francisco in November is currently the most expensive (average of $288). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

Reviews of airlines servicing San Francisco

Get insights into the airlines that provide service to San Francisco. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to San Francisco. Reviews last updated January 8, 2026.
Peruse reviews from past customers who have flown with Delta, United Airlines, and American Airlines from Knoxville to San Francisco to help guide your decision. You can also see how each airline stacks up in terms of entertainment options, comfort, food, crew/service, and boarding process.
Delta
7.9
Good
8,025 reviews

Entertainment

7.8

Food

7.2

Comfort

7.9

Crew

8.5

Overall

7.9

Boarding

8.1

Reviews

1 / 20
10.0
Excellent

Aaron,Oct 2024

TUS - LAX

Delta has consistently been the best U.S. airline for my travels and this flight was no exception
Delta
7.9
Good
8,025 reviews
Delta
7.9
Good
8,025 reviews

Entertainment

7.8

Food

7.2

Comfort

7.9

Crew

8.5

Overall

7.9

Boarding

8.1

Reviews

1 / 20
10.0
Excellent

Aaron,Oct 2024

TUS - LAX

Delta has consistently been the best U.S. airline for my travels and this flight was no exception
United Airlines
7.4
Good
9,139 reviews
Delta
7.9
Good
8,025 reviews

Entertainment

7.8

Food

7.2

Comfort

7.9

Crew

8.5

Overall

7.9

Boarding

8.1

Reviews

1 / 20
10.0
Excellent

Aaron,Oct 2024

TUS - LAX

Delta has consistently been the best U.S. airline for my travels and this flight was no exception
American Airlines
7.2
Good
11,096 reviews
Delta
7.9
Good
8,025 reviews

Entertainment

7.8

Food

7.2

Comfort

7.9

Crew

8.5

Overall

7.9

Boarding

8.1

Reviews

1 / 20
10.0
Excellent

Aaron,Oct 2024

TUS - LAX

Delta has consistently been the best U.S. airline for my travels and this flight was no exception
Frontier
5.7
Fair
3,061 reviews
Delta
7.9
Good
8,025 reviews

Entertainment

7.8

Food

7.2

Comfort

7.9

Crew

8.5

Overall

7.9

Boarding

8.1

Reviews

1 / 20
10.0
Excellent

Aaron,Oct 2024

TUS - LAX

Delta has consistently been the best U.S. airline for my travels and this flight was no exception

Related info for your journey

Find useful and relevant information for your journey from Knoxville to San Francisco. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • How long is the flight from Knoxville to San Francisco?

    Departing from Knoxville to San Francisco will take you 8h 10m. The distance between Knoxville and San Francisco is about 2114 mi. Both multi-stop and nonstop flights can be found to your destination and back.

  • What are the cheapest airlines flying from Knoxville to San Francisco round-trip?

    Flying on Frontier is currently your cheapest option to San Francisco, with prices starting at $180. Additional round-trip tickets that might be worth considering are offered by United Airlines and Delta, with the lowest prices starting at $286 and $308, respectively. Frontier is priced at 57% lower than the current average price of a flight leaving 3 months from now.

  • What are the cheapest airlines to fly from Knoxville to San Francisco one-way?

    The cheapest airline one-way is American Airlines, with whom users have recently found tickets for as low as $121. However, be on the lookout for offers from Frontier and United Airlines, as they are both options that can get you from Knoxville to San Francisco for a low price.

  • Can I find deals for flights from Knoxville to San Francisco that include hotel bookings?

    Yes. In addition to deals on Knoxville to San Francisco flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Knoxville to San Francisco?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Knoxville to San Francisco.

  • Can I find deals for business class flights from Knoxville to San Francisco?

    Yes. Cheapflights offers flight deals from Knoxville to San Francisco by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Knoxville to San Francisco?

    Currently, June is the cheapest month in which you can book a flight from Knoxville to San Francisco (average of $194). Flying from Knoxville to San Francisco in November is currently the most expensive (average of $288). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Traveling to a place near San Francisco?

Book flights to San Francisco if you plan to visit one of these locations
Roseville
South San Francisco
Santa Cruz
Santa Clara
Livermore
Watsonville
Redwood City
Sunnyvale
San Bruno
Daly City
Manteca
Turlock
San Carlos
San Ramon
Vallejo
San Lorenzo
Hollister
Foster City
Union City
Davis

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Top 4 airlines flying from Knoxville to San Francisco

Discover the top 4 airlines that operate flights from Knoxville to San Francisco. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated January 8, 2026.
AirlineCheapestAverageFlexibilityOn-time
FrontierCheapest$180Average$268FlexibilityNo cancel feeOn-time62%
United AirlinesCheapest$286Average$466FlexibilityNo cancel feeOn-time69%
DeltaCheapest$308Average$441FlexibilityNo cancel feeOn-timeN/A
American AirlinesCheapest$308Average$428FlexibilityNo cancel feeOn-time71%

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