How long is the flight from Des Moines to San Francisco Bay Area?

Airlines like Frontier, Delta, and American Airlines fly from Des Moines to San Francisco Bay Area in about 5h 51m. The time it takes to get you to your destination can typically vary by up to 5h 51m. The distance from Des Moines to San Francisco Bay Area is about 1527 mi. When browsing for deals, the options you’ll see will be for both nonstop flights and flights with stops.

What are the cheapest airlines to fly from Des Moines to San Francisco Bay Area one-way?

To fly one-way, consider booking your trip with Frontier, which is currently one of the cheapest options available, starting at $132. Delta flights start at $159 while deals on American Airlines start at $180 one-way.

In terms of precipitation, rainfall in San Francisco Bay Area ranges from 0.0 - 4.4 inches per month. January is typically the wettest month, when rainfall can reach 4.4 in. July is typically the driest time to visit San Francisco Bay Area when rainfall is around 0.0 in.

If weather is an important factor for your trip to San Francisco Bay Area, use this chart to help with planning. For those seeking warmer temperatures, September is the ideal time of year to visit, when temperatures reach an average of 62.6 F. Travelers looking to avoid the cold should look outside of January, when temperatures are typically at their lowest (around 51.8 F).

What are the most popular routes from Des Moines to San Francisco Bay Area?

Most travelers choose Des Moines - San Francisco, Des Moines - San Jose or Des Moines - Oakland when deciding on the best route from Des Moines to San Francisco Bay Area.

What are the most popular airlines that fly from Des Moines to San Francisco Bay Area?

Before booking your flight from Des Moines to San Francisco Bay Area check out the most popular airlines for this route: American Airlines, Delta or Frontier.

What airport do you fly from for flights from Des Moines to San Francisco Bay Area?

Des Moines (DSM) is the airport you will fly out of if you book a flight from Des Moines to San Francisco Bay Area. It is only a 3.6 mi journey to Des Moines (DSM) from Des Moines’s city center.

How can I find direct flights from Des Moines to San Francisco Bay Area?

After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Des Moines to San Francisco Bay Area.

Can I find deals for business class flights from Des Moines to San Francisco Bay Area?

Yes. Cheapflights offers flight deals from Des Moines to San Francisco Bay Area by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

$99+ Flights from Des Moines to San Francisco Bay Area

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Cheap flight deals from Des Moines to San Francisco Bay Area

Round-trip from	$149 (CheapOair)
One-way from	$99 (Kiwi.com)
Popular in	March
Cheapest in	September
Average price	$366

From Des Moines to San Francisco Bay Area

Search Deals

One-way flight from Des Moines to San Francisco Bay Area

Search Deals

Highest demand for flights based on searches. 7% potential increase in price ($34 potential increase over avg. RT price).

Search Deals

Cheapest flight prices on average. 0% potential price decrease ($5 potential savings vs. average RT price).

Search Deals

Average for round-trip flights in September 2025

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Find flight deals from Des Moines to San Francisco Bay Area

Cheapest flights from Des Moines to San Francisco Bay Area
Explore the most affordable flight options available from Des Moines to San Francisco Bay Area. Find the lowest fares from popular airlines and budget airlines, with prices last updated on September 17, 2025.

Fri 11/72:32 pmDSM - SFO

1 stop11h 42mFrontier

Mon 11/106:34 amSFO - DSM

1 stop5h 13mFrontier

Deal found 9/15

$149

Wed 10/152:37 pmDSM - SFO

1 stop9h 50mFrontier

Wed 10/299:55 pmSFO - DSM

2 stops13h 52mFrontier

Deal found 9/15

$189

Thu 10/302:32 pmDSM - SFO

1 stop11h 42mFrontier

Thu 11/66:34 amSFO - DSM

1 stop5h 13mFrontier

Deal found 9/15

$192

Wed 10/222:37 pmDSM - SFO

1 stop9h 50mFrontier

Sun 10/266:34 amSFO - DSM

1 stop5h 18mFrontier

Deal found 9/15

$195

Thu 10/162:37 pmDSM - SFO

2 stops35h 42mFrontier

Thu 10/236:34 amSFO - DSM

1 stop5h 18mFrontier

Deal found 9/16

$201

Thu 10/162:37 pmDSM - SFO

1 stop11h 37mFrontier

Mon 10/206:34 amSFO - DSM

1 stop5h 18mFrontier

Deal found 9/16

$214

Fri 10/312:32 pmDSM - SFO

1 stop11h 42mFrontier

Fri 11/710:21 pmSFO - DSM

2 stops37h 26mFrontier

Deal found 9/16

$216

Fri 9/262:25 pmDSM - SFO

1 stop11h 51mFrontier

Sun 9/286:29 amSFO - DSM

1 stop5h 11mFrontier

Deal found 9/15

$220

Thu 10/22:25 pmDSM - SJC

1 stop23h 05mFrontier

Sun 10/512:26 pmSJC - DSM

1 stop23h 14mFrontier

Deal found 9/15

$239

Sat 11/13:30 pmDSM - SJC

1 stop6h 56mDelta

Tue 11/46:35 amSJC - DSM

1 stop9h 09mDelta

Deal found 9/16

$288

Thu 10/165:30 amDSM - SJC

1 stop5h 51mAmerican Airlines

Wed 10/226:00 amSJC - DSM

1 stop7h 03mAmerican Airlines

Deal found 9/15

$309

Thu 10/162:40 pmDSM - SJC

2 stops10h 19mDelta

Wed 10/226:20 amSJC - DSM

1 stop8h 56mDelta

Deal found 9/15

$314

Best flights from Des Moines to San Francisco Bay Area
Discover carefully curated flight deals from Des Moines to San Francisco Bay Area that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated September 17, 2025.

Fri 11/72:32 pmDSM - SFO

1 stop11h 42mFrontier

Mon 11/106:34 amSFO - DSM

1 stop5h 13mFrontier

Deal found 9/17

$149

Sat 11/13:30 pmDSM - SJC

1 stop6h 56mDelta

Tue 11/46:35 amSJC - DSM

1 stop9h 09mDelta

Deal found 9/16

$288

Thu 10/165:30 amDSM - SJC

1 stop5h 51mAmerican Airlines

Wed 10/226:00 amSJC - DSM

1 stop7h 03mAmerican Airlines

Deal found 9/15

$309

Wed 10/17:30 amDSM - SFO

1 stop27h 14mMultiple Airlines

Sun 10/56:20 pmSFO - DSM

1 stop26h 17mMultiple Airlines

Deal found 9/15

$314

Tue 10/1411:31 amDSM - SFO

1 stop7h 49mUnited Airlines

Tue 10/215:05 amSFO - DSM

1 stop5h 32mUnited Airlines

Deal found 9/15

$337

Wed 12/108:20 amDSM - OAK

1 stop8h 20mSouthwest

Sat 12/131:05 pmOAK - DSM

1 stop5h 20mSouthwest

Deal found 9/17

$348

Thu 10/302:32 pmDSM - SFO

1 stop11h 42mFrontier

Thu 11/66:34 amSFO - DSM

1 stop5h 13mFrontier

Deal found 9/15

$192

Fri 11/142:34 pmDSM - SFO

1 stop11h 40mFrontier

Mon 11/176:34 amSFO - DSM

1 stop5h 13mFrontier

Deal found 9/15

$214

Fri 9/262:25 pmDSM - SFO

2 stops11h 50mFrontier

Sun 9/286:29 amSFO - DSM

1 stop5h 11mFrontier

Deal found 9/15

$234

Fri 10/315:04 amDSM - STS

2 stops19h 01mAlaska Airlines

Fri 11/78:03 pmSTS - DSM

2 stops10h 29mAlaska Airlines

Deal found 9/16

$579

Thu 9/252:25 pmDSM - SFO

1 stop11h 51mFrontier

Mon 9/296:29 amSFO - DSM

1 stop5h 11mFrontier

Deal found 9/16

$235

Thu 10/162:40 pmDSM - SJC

2 stops10h 19mDelta

Wed 10/226:20 amSJC - DSM

1 stop8h 56mDelta

Deal found 9/16

$314

Thu 10/22:25 pmDSM - SFO

2 stops10h 50mMultiple Airlines

Mon 10/65:45 amSFO - DSM

1 stop14h 52mMultiple Airlines

Deal found 9/16

$321

Wed 12/1011:29 amDSM - SFO

1 stop9h 55mAmerican Airlines

Sat 12/138:20 amSFO - DSM

1 stop13h 39mAmerican Airlines

Deal found 9/17

$347

Sat 11/13:30 pmDSM - SJC

1 stop6h 56mDelta

Sat 11/86:20 amSJC - DSM

1 stop5h 47mDelta

Deal found 9/17

$317

Wed 11/512:05 pmDSM - OAK

1 stop5h 40mSouthwest

Mon 11/107:10 amOAK - DSM

1 stop8h 25mSouthwest

Deal found 9/15

$358

Wed 11/512:05 pmDSM - OAK

1 stop5h 40mSouthwest

Sun 11/97:20 amOAK - DSM

1 stop6h 10mSouthwest

Deal found 9/15

$392

Sat 11/111:06 amDSM - OAK

2 stops12h 26mDelta

Tue 11/45:55 amOAK - DSM

2 stops9h 21mDelta

Deal found 9/16

$358

Thu 11/68:00 amDSM - OAK

1 stop9h 20mSouthwest

Mon 11/107:20 amOAK - DSM

1 stop6h 10mSouthwest

Deal found 9/15

$414

Fri 10/317:30 amDSM - STS

2 stops10h 17mAmerican Airlines

Fri 11/74:23 pmSTS - DSM

1 stop5h 36mAmerican Airlines

Deal found 9/16

$556

Sat 10/115:00 amDSM - STS

2 stops10h 36mAlaska Airlines

Tue 10/147:05 amSTS - DSM

2 stops11h 06mAlaska Airlines

Deal found 9/16

$699

Sat 10/113:09 pmDSM - STS

2 stops23h 12mAmerican Airlines

Tue 10/1412:53 pmSTS - DSM

1 stop6h 23mAmerican Airlines

Deal found 9/15

$690

Sat 10/185:30 amDSM - STS

1 stop12h 17mAmerican Airlines

Sun 10/194:17 pmSTS - DSM

1 stop19h 41mAmerican Airlines

Deal found 9/15

$703

Mon 9/295:10 amDSM - STS

1 stop8h 45mAmerican Airlines

Wed 10/112:25 pmSTS - DSM

1 stop8h 48mAmerican Airlines

Deal found 9/15

$719

Last-minute flights from Des Moines to San Francisco Bay Area
Discover last-minute flight deals from Des Moines to San Francisco Bay Area. Data last updated September 17, 2025 and is based on user searches.

Fri 9/262:25 pmDSM - SFO

1 stop11h 51mFrontier

Sun 9/286:29 amSFO - DSM

1 stop5h 11mFrontier

Deal found 9/15

$220

Thu 10/22:25 pmDSM - SJC

1 stop23h 05mFrontier

Sun 10/512:26 pmSJC - DSM

1 stop23h 14mFrontier

Deal found 9/15

$239

Wed 10/152:37 pmDSM - SFO

1 stop9h 50mFrontier

Wed 10/299:55 pmSFO - DSM

2 stops13h 52mFrontier

Deal found 9/15

$189

Thu 10/162:37 pmDSM - SFO

1 stop11h 37mFrontier

Thu 10/236:34 amSFO - DSM

1 stop5h 18mFrontier

Deal found 9/16

$149

Thu 10/162:37 pmDSM - SFO

1 stop11h 37mFrontier

Mon 10/206:34 amSFO - DSM

1 stop5h 18mFrontier

Deal found 9/16

$214

Thu 10/165:30 amDSM - SJC

1 stop5h 51mAmerican Airlines

Wed 10/226:00 amSJC - DSM

1 stop7h 03mAmerican Airlines

Deal found 9/15

$309

Thu 10/162:40 pmDSM - SJC

2 stops10h 19mDelta

Wed 10/226:20 amSJC - DSM

1 stop8h 56mDelta

Deal found 9/15

$314

Thu 10/165:30 amDSM - SJC

1 stop5h 51mAmerican Airlines

Thu 10/236:00 amSJC - DSM

1 stop5h 47mAmerican Airlines

Deal found 9/15

$359

Wed 10/222:37 pmDSM - SFO

1 stop9h 50mFrontier

Sun 10/266:34 amSFO - DSM

1 stop5h 18mFrontier

Deal found 9/15

$195

Thu 10/302:32 pmDSM - SFO

1 stop11h 42mFrontier

Thu 11/66:34 amSFO - DSM

1 stop5h 13mFrontier

Deal found 9/15

$192

Thu 10/302:13 pmDSM - SJC

1 stop10h 45mDelta

Thu 11/65:55 amSJC - DSM

2 stops9h 21mDelta

Deal found 9/15

$379

Fri 10/312:32 pmDSM - SFO

1 stop11h 42mFrontier

Fri 11/710:21 pmSFO - DSM

2 stops37h 26mFrontier

Deal found 9/16

$216

One-way flights from Des Moines to San Francisco Bay Area
Search for one-way flight options from Des Moines to San Francisco Bay Area. Find affordable one-way fares based on user searches. Data last updated September 17, 2025.

Wed 10/82:37 pmDSM - SFO

1 stop9h 50mFrontier

Deal found 9/17

$99

Mon 11/172:32 pmDSM - SFO

1 stop11h 42mFrontier

Deal found 9/17

$123

Sun 10/53:43 pmDSM - SFO

2 stops45h 12mMultiple Airlines

Deal found 9/17

$154

Wed 10/82:40 pmDSM - SJC

1 stop7h 46mDelta

Deal found 9/17

$159

Mon 10/63:40 pmDSM - SFO

2 stops21h 15mMultiple Airlines

Deal found 9/17

$163

Fri 9/262:25 pmDSM - SFO

1 stop11h 51mFrontier

Deal found 9/15

$164

Tue 10/143:10 pmDSM - SFO

1 stop6h 45mAmerican Airlines

Deal found 9/15

$169

Mon 9/292:25 pmDSM - SFO

2 stops10h 50mFrontier

Deal found 9/17

$174

Mon 10/62:25 pmDSM - SFO

2 stops46h 30mFrontier

Deal found 9/17

$175

Mon 10/135:51 pmDSM - SFO

3 stops43h 04mMultiple Airlines

Deal found 9/16

$180

Thu 10/302:28 pmDSM - SJC

1 stop6h 01mAmerican Airlines

Deal found 9/15

$180

Thu 10/3011:06 amDSM - SJC

2 stops12h 25mDelta

Deal found 9/15

$185

Cheapflights Fare Finder

Use the filters below to find and compare flights from Des Moines to San Francisco Bay Area that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Des MoinesSan Francisco

DSM - SFO

DSMSFO

Des Moines

Fri 11/7

2:32 pm-12:14 am

1 stop11h 42m

San Francisco

Mon 11/10

6:34 am-1:47 pm

1 stop5h 13m

$149

Des MoinesSan Francisco

DSM - SFO

DSMSFO

Des Moines

Thu 10/30

2:32 pm-12:14 am

1 stop11h 42m

San Francisco

Thu 11/6

6:34 am-1:47 pm

1 stop5h 13m

$192

Des MoinesSan Francisco

DSM - SFO

DSMSFO

Des Moines

Fri 11/14

2:34 pm-12:14 am

1 stop11h 40m

San Francisco

Mon 11/17

6:34 am-1:47 pm

1 stop5h 13m

$214

Des MoinesSan Francisco

DSM - SFO

DSMSFO

Des Moines

Fri 9/26

2:25 pm-12:15 am

2 stops11h 50m

San Francisco

Sun 9/28

6:29 am-1:40 pm

1 stop5h 11m

$234

Des MoinesSan Francisco

DSM - SFO

DSMSFO

Des Moines

Thu 9/25

2:25 pm-12:16 am

1 stop11h 51m

San Francisco

Mon 9/29

6:29 am-1:40 pm

1 stop5h 11m

$235

Des MoinesSan Jose

DSM - SJC

DSMSJC

Des Moines

Sat 11/1

3:30 pm-8:26 pm

1 stop6h 56m

San Jose

Tue 11/4

6:35 am-5:44 pm

1 stop9h 09m

$288

Des MoinesSan Jose

DSM - SJC

DSMSJC

Des Moines

Thu 10/16

5:30 am-9:21 am

1 stop5h 51m

San Jose

Wed 10/22

6:00 am-3:03 pm

1 stop7h 03m

$309

Des MoinesSan Francisco

DSM - SFO

DSMSFO

Des Moines

Wed 10/1

7:30 am-8:44 am

1 stop27h 14m

San Francisco

Sun 10/5

6:20 pm-10:37 pm

1 stop26h 17m

$314

Des MoinesSan Jose

DSM - SJC

DSMSJC

Des Moines

Thu 10/16

2:40 pm-10:59 pm

2 stops10h 19m

San Jose

Wed 10/22

6:20 am-5:16 pm

1 stop8h 56m

$314

Des MoinesSan Jose

DSM - SJC

DSMSJC

Des Moines

Sat 11/1

3:30 pm-8:26 pm

1 stop6h 56m

San Jose

Sat 11/8

6:20 am-2:07 pm

1 stop5h 47m

$317

Flights are sorted by cheapest round-trip flights first.

Deals found on 9/17

Showing 1-10 of 54 results

...

Best time to book a flight from Des Moines to San Francisco Bay Area

Have a flexible travel schedule? Discover the best time to fly to San Francisco Bay Area from Des Moines with our price prediction graph.

Estimated round-trip price

Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Des Moines to San Francisco Bay Area

What is the cheapest month to book a flight from Des Moines to San Francisco Bay Area?

Currently, January is the cheapest month in which you can book a flight from Des Moines to San Francisco Bay Area (average of $276). Flying from Des Moines to San Francisco Bay Area in June is currently the most expensive (average of $357). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from DSM to XIH?

When flying from Des Moines to San Francisco Bay Area, the time of day you decide to fly out makes little to no difference towards the overall price you’ll pay on tickets.

Reviews of airlines servicing San Francisco Bay Area

Read reviews from past customers who have flown Southwest, Delta, and United Airlines from Des Moines to San Francisco Bay Area. You can also see how each airline compares in terms of entertainment options, comfort, food, crew/service, and boarding process.

Southwest

8.0

Very good

4,242 reviews

Reviews

1 / 20

8.0

Excellent

Walter,Aug 2025

OAK - SAN

Dozens of flights and I've never seen a row's beverages forgotten. I even went back and asked the attendant to check on them and nothing. I really hope it didn't have something to do with the Black mother with her kid in the row. Otherwise it was a typical Southwest flight, rapid boarding, tolerable leg room.

Southwest

8.0

Very good

4,242 reviews

Southwest

8.0

Very good

4,242 reviews

Reviews

1 / 20

8.0

Excellent

Walter,Aug 2025

OAK - SAN

Delta

8.0

Very good

7,961 reviews

Southwest

8.0

Very good

4,242 reviews

Reviews

1 / 20

8.0

Excellent

Walter,Aug 2025

OAK - SAN

United Airlines

7.4

Good

8,926 reviews

Southwest

8.0

Very good

4,242 reviews

Reviews

1 / 20

8.0

Excellent

Walter,Aug 2025

OAK - SAN

American Airlines

7.2

Good

10,000 reviews

Southwest

8.0

Very good

4,242 reviews

Reviews

1 / 20

8.0

Excellent

Walter,Aug 2025

OAK - SAN

Frontier

5.8

Fair

3,173 reviews

Southwest

8.0

Very good

4,242 reviews

Reviews

1 / 20

8.0

Excellent

Walter,Aug 2025

OAK - SAN

Related info for your journey

What airport do you fly from for flights from Des Moines to San Francisco Bay Area?
Des Moines (DSM) is the airport you will fly out of if you book a flight from Des Moines to San Francisco Bay Area. It is only a 3.6 mi journey to Des Moines (DSM) from Des Moines’s city center.
How long is the flight from Des Moines to San Francisco Bay Area?
Airlines like Frontier, Delta, and American Airlines fly from Des Moines to San Francisco Bay Area in about 5h 51m. The time it takes to get you to your destination can typically vary by up to 5h 51m. The distance from Des Moines to San Francisco Bay Area is about 1527 mi. When browsing for deals, the options you’ll see will be for both nonstop flights and flights with stops.
What are the cheapest airlines to fly from Des Moines to San Francisco Bay Area one-way?
To fly one-way, consider booking your trip with Frontier, which is currently one of the cheapest options available, starting at $132. Delta flights start at $159 while deals on American Airlines start at $180 one-way.
What are the most popular routes from Des Moines to San Francisco Bay Area?
Most travelers choose Des Moines - San Francisco, Des Moines - San Jose or Des Moines - Oakland when deciding on the best route from Des Moines to San Francisco Bay Area.
Can I find deals for flights from Des Moines to San Francisco Bay Area that include hotel bookings?
Yes. In addition to deals on Des Moines to San Francisco Bay Area flights, Cheapflights offers vacation packages that include both flights and hotel.
How can I find direct flights from Des Moines to San Francisco Bay Area?
After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Des Moines to San Francisco Bay Area.
Can I find deals for business class flights from Des Moines to San Francisco Bay Area?
Yes. Cheapflights offers flight deals from Des Moines to San Francisco Bay Area by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.
What is the cheapest month to book a flight from Des Moines to San Francisco Bay Area?
Currently, January is the cheapest month in which you can book a flight from Des Moines to San Francisco Bay Area (average of $276). Flying from Des Moines to San Francisco Bay Area in June is currently the most expensive (average of $357). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Browse thousands of different options on Cheapflights for your next trip

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Top 5 airlines flying from Des Moines to San Francisco Bay Area

Airline	Cheapest	Average	Flexibility	On-time
Frontier	Cheapest$118	Average$260	FlexibilityNo cancel fee	On-time62%
Delta	Cheapest$265	Average$382	FlexibilityNo cancel fee	On-timeN/A
United Airlines	Cheapest$296	Average$517	FlexibilityNo cancel fee	On-time69%
American Airlines	Cheapest$296	Average$535	FlexibilityNo cancel fee	On-time71%
Southwest	Cheapest$344	Average$472	FlexibilityNo cancel fee	On-time63%

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$99+ Cheap flights from Des Moines (DSM) to San Francisco Bay Area

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 10/8. Fares are subject to change and may not be available on all flights or dates of travel.

Find cheap flights from Des Moines to San Francisco Bay Area with Cheapflights

1. Tell us where you want to go

2. Select your favorite providers

3. Compare prices and book

Cheap flight deals from Des Moines to San Francisco Bay Area

Keep the following information in mind while searching for Des Moines to San Francisco Bay Area flight deals. Data was last updated September 17, 2025.

Round-trip from

One-way from

Popular in

Cheapest in

Average price

Find flight deals from Des Moines to San Francisco Bay Area

Cheapest flights from Des Moines to San Francisco Bay AreaExplore the most affordable flight options available from Des Moines to San Francisco Bay Area. Find the lowest fares from popular airlines and budget airlines, with prices last updated on September 17, 2025.

Explore the most affordable flight options available from Des Moines to San Francisco Bay Area. Find the lowest fares from popular airlines and budget airlines, with prices last updated on September 17, 2025.

Cheapflights Fare Finder

Use the filters below to find and compare flights from Des Moines to San Francisco Bay Area that are best for you.

Best time to book a flight from Des Moines to San Francisco Bay Area

Have a flexible travel schedule? Discover the best time to fly to San Francisco Bay Area from Des Moines with our price prediction graph.

Cheapflights Insights

Everything you need to know about your flight from Des Moines to San Francisco Bay Area

What is the cheapest month to book a flight from Des Moines to San Francisco Bay Area?

What is the cheapest time of day to fly from DSM to XIH?

Find hourly flight availability from Des Moines to San Francisco Bay Area. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated September 17, 2025.

Reviews of airlines servicing San Francisco Bay Area

Read reviews from past customers who have flown Southwest, Delta, and United Airlines from Des Moines to San Francisco Bay Area. You can also see how each airline compares in terms of entertainment options, comfort, food, crew/service, and boarding process.

Related info for your journey

Find useful and relevant information for your journey from Des Moines to San Francisco Bay Area. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

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Cheapest flights from Des Moines to San Francisco Bay Area
Explore the most affordable flight options available from Des Moines to San Francisco Bay Area. Find the lowest fares from popular airlines and budget airlines, with prices last updated on September 17, 2025.