$325+ Cheap flights from Panama City, FL to San Diego (ECP - SAN)
This is the cheapest round-trip flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 9/9. Fares are subject to change and may not be available on all flights or dates of travel.
ECP — SAN
Aug 3 — Aug 101
1 adult, Economy
We work with more than 300 partners to bring you better travel deals
Find cheap flights from Panama City to San Diego with Cheapflights
1. Tell us where you want to go
Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”2. Select your favorite providers
We find the providers serving your travel needs. Choose up to four travel providers to compare side-by-side for flights, hotels, or car rentals.3. Compare prices and book
Review each provider’s pricing and select the best option for you! Book through your favorite provider’s website for a seamless experience.Cheap flight deals from Panama City to San Diego
Discover tips and strategies to find the most affordable flight options for your journey from Panama City (ECP) to San Diego (SAN). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated July 29, 2025.
Round-trip from | $325 (American Airlines) |
|---|---|
Popular in | March |
Cheapest in | September |
Average price | $492 |
Find flight deals from Panama City to San Diego
Cheapest flights from Panama City to San DiegoExplore the most affordable flight options available from Panama City to San Diego. Find the lowest fares from popular airlines and budget airlines, with prices last updated on July 29, 2025.
Explore the most affordable flight options available from Panama City to San Diego. Find the lowest fares from popular airlines and budget airlines, with prices last updated on July 29, 2025.
This American Airlines deal was found by Cheapflights users on 7/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 9/93:53 pmECP - SAN
1 stop6h 27mAmerican Airlines
Sat 9/139:19 pmSAN - ECP
1 stop10h 23mAmerican Airlines
Deal found 7/28![American Airlines logo]()
$325
This Delta deal was found by Cheapflights users on 7/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 9/286:54 pmECP - SAN
1 stop6h 30mDelta
Wed 10/110:55 amSAN - ECP
1 stop6h 35mDelta
Deal found 7/28![Delta logo]()
$371
This Southwest deal was found by Cheapflights users on 7/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/101:15 pmECP - SAN
1 stop7h 15mSouthwest
Wed 9/178:30 amSAN - ECP
2 stops9h 35mSouthwest
Deal found 7/28![Southwest logo]()
$392
This United Airlines deal was found by Cheapflights users on 7/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 8/286:30 amECP - SAN
2 stops9h 10mUnited Airlines
Mon 9/16:15 amSAN - ECP
1 stop8h 05mUnited Airlines
Deal found 7/29![United Airlines logo]()
$438
Cheapflights Fare Finder
Customize your flight search to find flights from Panama City to San Diego that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated July 29, 2025.
Use the filters below to find and compare flights from Panama City to San Diego that are best for you.
Fly from
Panama City
Fly to
San Diego
Route
Depart
Return
Price
Panama CitySan Diego
ECP - SAN
ECPSAN
Panama City NW Florida Beaches
Tue 9/9
3:53 pm-8:20 pm
1 stop6h 27m
San Diego
Sat 9/13
9:19 pm-9:42 am
1 stop10h 23m
$325
Panama CitySan Diego
ECP - SAN
ECPSAN
Panama City NW Florida Beaches
Sun 9/28
6:54 pm-11:24 pm
1 stop6h 30m
San Diego
Wed 10/1
10:55 am-7:30 pm
1 stop6h 35m
$371
Panama CitySan Diego
ECP - SAN
ECPSAN
Panama City NW Florida Beaches
Wed 9/10
1:15 pm-6:30 pm
1 stop7h 15m
San Diego
Wed 9/17
8:30 am-8:05 pm
2 stops9h 35m
$392
Panama CitySan Diego
ECP - SAN
ECPSAN
Panama City NW Florida Beaches
Thu 8/28
6:30 am-1:40 pm
2 stops9h 10m
San Diego
Mon 9/1
6:15 am-4:20 pm
1 stop8h 05m
$438
Panama CitySan Diego
ECP - SAN
ECPSAN
Panama City NW Florida Beaches
Mon 8/4
5:17 pm-12:09 am
1 stop8h 52m
$424
Panama CitySan Diego
ECP - SAN
ECPSAN
Panama City NW Florida Beaches
Mon 8/4
8:40 am-8:01 pm
2 stops13h 21m
$429
Best time to book a flight from Panama City to San Diego
Have a flexible travel schedule? Discover the best time to fly to San Diego from Panama City with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.
Cheapflights Insights
Everything you need to know about your flight from Panama City to San Diego
What is the cheapest month to book a flight from Panama City, Florida to San Diego?
Currently, August is the cheapest month in which you can book a flight from Panama City, Florida to San Diego (average of $286). Flying from Panama City, Florida to San Diego in March is currently the most expensive (average of $366). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.
What is the cheapest time of day to fly from ECP to SAN?
Find hourly flight availability from Panama City to San Diego. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated July 29, 2025.
One of the essential ways to save on airfare from Panama City, Florida to San Diego is to remain as flexible as possible. Flights that are at noon tend to be the most expensive. A flight in the evening could potentially save you up to 8% on airfare.
Reviews of airlines servicing San Diego
Get insights into the airlines that provide service to San Diego. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to San Diego. Reviews last updated July 29, 2025.
Read through reviews of airlines operating flights from Panama City to San Diego, such as Southwest, Delta, and United Airlines. Reviews also offer insight into each airline's entertainment options, comfort, food, crew/service, and boarding process.
Comfort
8.0
Boarding
8.1
Overall
8.0
Entertainment
7.5
Food
7.0
Crew
8.6
Reviews
1 / 20
10.0
ExcellentMerlyn,Feb 2025
LAX - SMF
Comfort
8.0
Boarding
8.1
Overall
8.0
Entertainment
7.5
Food
7.0
Crew
8.6
Reviews
1 / 20
10.0
ExcellentMerlyn,Feb 2025
LAX - SMF
Comfort
8.0
Boarding
8.1
Overall
8.0
Entertainment
7.5
Food
7.0
Crew
8.6
Reviews
1 / 20
10.0
ExcellentMerlyn,Feb 2025
LAX - SMF
Comfort
8.0
Boarding
8.1
Overall
8.0
Entertainment
7.5
Food
7.0
Crew
8.6
Reviews
1 / 20
10.0
ExcellentMerlyn,Feb 2025
LAX - SMF
Comfort
8.0
Boarding
8.1
Overall
8.0
Entertainment
7.5
Food
7.0
Crew
8.6
Reviews
1 / 20
10.0
ExcellentMerlyn,Feb 2025
LAX - SMF
Related info for your journey
Find useful and relevant information for your journey from Panama City to San Diego. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.
Traveling to a place near San Diego?
Book flights to San Diego if you plan to visit one of these locationsEl Cajon
Chula Vista
Coronado
Poway
National City
Lemon Grove
Imperial Beach
La Mesa
Alpine
Santee
Browse thousands of different options on Cheapflights for your next trip
Toggle through the tabs below to find thousands of options on Cheapflights for your next trip.
Alternative routes for Panama City to San Diego
See prices for flight routes from nearby airports that may be better suited for you.
Top 4 airlines flying from Panama City to San Diego
Discover the top 4 airlines that operate flights from Panama City to San Diego. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated July 29, 2025.
| Airline | Cheapest | Average | Flexibility | On-time |
|---|---|---|---|---|
| Cheapest$296 | Average$434 | FlexibilityNo cancel fee | On-timeN/A | |
| Cheapest$326 | Average$546 | FlexibilityNo cancel fee | On-time63% | |
| Cheapest$348 | Average$416 | FlexibilityNo cancel fee | On-time71% | |
| Cheapest$386 | Average$486 | FlexibilityNo cancel fee | On-time69% |