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$176+ Cheap flights from Panama City, FL to San Diego (ECP - SAN)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 12/17. Fares are subject to change and may not be available on all flights or dates of travel.
ECP — SAN
Nov 28 — Dec 51
Fri 11/28
Fri 12/5
1 adult, Economy
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Cheap flight deals from Panama City to San Diego

Discover tips and strategies to find the most affordable flight options for your journey from Panama City (ECP) to San Diego (SAN). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated October 29, 2025.

Most accurate provider

eDreams
3 stars

Most trusted provider

eDreams
3 stars

Round-trip from

$351
(Southwest)

One-way from

$176
(American Airlines)

Popular in

February

Cheapest in

May

Average price

$358
Provider with most accurate pricing for Panama City NW Florida Beaches-San Diego flight deals.
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Provider most trusted by Cheapflights users for Panama City NW Florida Beaches-San Diego flights.
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From Panama City NW Florida Beaches to San Diego
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One-way flight from Panama City NW Florida Beaches to San Diego
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Highest demand for flights based on searches. 12% potential increase in price ($68 potential increase over avg. RT price).
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Cheapest flight prices on average. 2% potential price decrease ($12 potential savings vs. average RT price).
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Average for round-trip flights in October 2025
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Find flight deals from Panama City to San Diego

Cheapest flights from Panama City to San Diego
Explore the most affordable flight options available from Panama City to San Diego. Find the lowest fares from popular airlines and budget airlines, with prices last updated on October 29, 2025.

This Delta deal was found by Cheapflights users on 10/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 11/267:02 amECP - SAN
1 stop8h 01mDelta
Wed 12/310:30 pmSAN - ECP
1 stop8h 44mDelta
Deal found 10/27$364
This American Airlines deal was found by Cheapflights users on 10/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 11/262:37 pmECP - SAN
1 stop8h 23mAmerican Airlines
Wed 12/310:47 amSAN - ECP
2 stops10h 23mAmerican Airlines
Deal found 10/27$369
This Southwest deal was found by Cheapflights users on 10/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/34:25 pmECP - SAN
1 stop9h 00mSouthwest
Fri 12/57:35 amSAN - ECP
1 stop6h 15mSouthwest
Deal found 10/28$380
This American Airlines deal was found by Cheapflights users on 10/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 12/512:55 pmECP - SAN
1 stop9h 21mAmerican Airlines
Mon 12/812:43 pmSAN - ECP
1 stop8h 27mAmerican Airlines
Deal found 10/27$393
This Southwest deal was found by Cheapflights users on 10/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 11/264:15 pmECP - SAN
2 stops9h 10mSouthwest
Wed 12/36:40 amSAN - ECP
2 stops10h 25mSouthwest
Deal found 10/27$414
This American Airlines deal was found by Cheapflights users on 10/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 11/212:37 pmECP - SAN
1 stop8h 23mAmerican Airlines
Fri 11/2810:47 amSAN - ECP
1 stop8h 28mAmerican Airlines
Deal found 10/27$467

Cheapflights Fare Finder

 
Customize your flight search to find flights from Panama City to San Diego that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated October 29, 2025.
Use the filters below to find and compare flights from Panama City to San Diego that are best for you.

Fly from

Panama City

Fly to

San Diego

Route

Depart

Return

Price

Panama CitySan Diego

ECP - SAN

ECPSAN

Panama City NW Florida Beaches

Thu 1/29

3:45 pm-11:05 pm

1 stop9h 20m

San Diego

Wed 2/4

7:25 am-6:10 pm

1 stop8h 45m

$351

Panama CitySan Diego

ECP - SAN

ECPSAN

Panama City NW Florida Beaches

Wed 11/26

7:02 am-1:03 pm

1 stop8h 01m

San Diego

Wed 12/3

10:30 pm-9:14 am

1 stop8h 44m

$364

Panama CitySan Diego

ECP - SAN

ECPSAN

Panama City NW Florida Beaches

Wed 11/26

2:37 pm-9:00 pm

1 stop8h 23m

San Diego

Wed 12/3

10:47 am-11:10 pm

2 stops10h 23m

$369

Panama CitySan Diego

ECP - SAN

ECPSAN

Panama City NW Florida Beaches

Wed 12/3

4:25 pm-11:25 pm

1 stop9h 00m

San Diego

Fri 12/5

7:35 am-3:50 pm

1 stop6h 15m

$380

Panama CitySan Diego

ECP - SAN

ECPSAN

Panama City NW Florida Beaches

Fri 12/5

12:55 pm-8:16 pm

1 stop9h 21m

San Diego

Mon 12/8

12:43 pm-11:10 pm

1 stop8h 27m

$393

Panama CitySan Diego

ECP - SAN

ECPSAN

Panama City NW Florida Beaches

Wed 11/26

4:15 pm-11:25 pm

2 stops9h 10m

San Diego

Wed 12/3

6:40 am-7:05 pm

2 stops10h 25m

$414

Panama CitySan Diego

ECP - SAN

ECPSAN

Panama City NW Florida Beaches

Fri 11/21

2:37 pm-9:00 pm

1 stop8h 23m

San Diego

Fri 11/28

10:47 am-9:15 pm

1 stop8h 28m

$467

Panama CitySan Diego

ECP - SAN

ECPSAN

Panama City NW Florida Beaches

Wed 12/17

12:08 pm-7:43 pm

1 stop9h 35m

$176

Panama CitySan Diego

ECP - SAN

ECPSAN

Panama City NW Florida Beaches

Wed 12/17

6:30 am-3:04 pm

2 stops10h 34m

$181

Panama CitySan Diego

ECP - SAN

ECPSAN

Panama City NW Florida Beaches

Fri 11/21

11:11 am-6:20 pm

1 stop9h 09m

$249

Flights are sorted by cheapest round-trip flights first.

Deals found on 10/27

Showing 1-10 of 16 results
1
2

Compare providers for flights from Panama City to San Diego

Provider information is updated monthly. Please note that these providers often have deals for this flight, but the availability may vary on a day-by-day basis on Cheapflights.
Use the table below to compare price accuracy, trust ratings, and cancellation policies for each provider offering flight deals from Panama City to San Diego in October.
ProviderPrice AccuracyTrust Score*
ExpediaPrice Accuracy2 starsTrust Score*3 stars
FlightHubPrice Accuracy3 starsTrust Score*1 star
eDreamsPrice Accuracy3 starsTrust Score*3 stars
PricelinePrice Accuracy1 starTrust Score*3 stars

*The Trust Score is based on feedback from users after their booking experience. It measures overall satisfaction, helping us identify issues like hidden fees, problems during the ticketing process, and the quality of customer service. This score is our best indicator of the provider's quality and reliability.

  • Most accurate provider: When it comes to deals on Panama City, Florida-San Diego flights, users find the pricing of eDreams to be most consistent on Cheapflights vs. eDreams Users can find the same prices on Panama City, Florida-San Diego flight deals on Cheapflights vs. eDreams >95% of the time. Price accuracy is based on data collected from Panama City, Florida-San Diego flight searches over the past month and is updated monthly.
  • Most trusted provider: When it comes to deals on Panama City, Florida-San Diego flights, Cheapflights users trust eDreams the most. eDreams has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for Panama City, Florida-San Diego flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.

Best time to book a flight from Panama City to San Diego

Have a flexible travel schedule? Discover the best time to fly to San Diego from Panama City with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Panama City to San Diego

What is the cheapest month to book a flight from Panama City, Florida to San Diego?

Currently, November is the cheapest month in which you can book a flight from Panama City, Florida to San Diego (average of $108). Flying from Panama City, Florida to San Diego in July is currently the most expensive (average of $306). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from ECP to SAN?

Find hourly flight availability from Panama City to San Diego. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated October 29, 2025.

One of the essential ways to save on airfare from Panama City, Florida to San Diego is to remain as flexible as possible. Flights that are at noon tend to be the most expensive. A flight in the evening could potentially save you up to 7% on airfare.

Reviews of airlines servicing San Diego

Get insights into the airlines that provide service to San Diego. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to San Diego. Reviews last updated October 29, 2025.
Read through reviews of airlines operating flights from Panama City to San Diego, such as Southwest, Delta, and United Airlines. Reviews also offer insight into each airline's entertainment options, comfort, food, crew/service, and boarding process.
Southwest
8.0
Very good
4,241 reviews

Overall

8.0

Comfort

8.0

Entertainment

7.5

Food

7.0

Boarding

8.1

Crew

8.6

Reviews

1 / 20
8.0
Excellent

Walter,Aug 2025

OAK - SAN

Dozens of flights and I've never seen a row's beverages forgotten. I even went back and asked the attendant to check on them and nothing. I really hope it didn't have something to do with the Black mother with her kid in the row. Otherwise it was a typical Southwest flight, rapid boarding, tolerable leg room.
Southwest
8.0
Very good
4,241 reviews
Southwest
8.0
Very good
4,241 reviews

Overall

8.0

Comfort

8.0

Entertainment

7.5

Food

7.0

Boarding

8.1

Crew

8.6

Reviews

1 / 20
8.0
Excellent

Walter,Aug 2025

OAK - SAN

Dozens of flights and I've never seen a row's beverages forgotten. I even went back and asked the attendant to check on them and nothing. I really hope it didn't have something to do with the Black mother with her kid in the row. Otherwise it was a typical Southwest flight, rapid boarding, tolerable leg room.
Delta
7.9
Good
7,992 reviews
Southwest
8.0
Very good
4,241 reviews

Overall

8.0

Comfort

8.0

Entertainment

7.5

Food

7.0

Boarding

8.1

Crew

8.6

Reviews

1 / 20
8.0
Excellent

Walter,Aug 2025

OAK - SAN

Dozens of flights and I've never seen a row's beverages forgotten. I even went back and asked the attendant to check on them and nothing. I really hope it didn't have something to do with the Black mother with her kid in the row. Otherwise it was a typical Southwest flight, rapid boarding, tolerable leg room.
United Airlines
7.4
Good
8,999 reviews
Southwest
8.0
Very good
4,241 reviews

Overall

8.0

Comfort

8.0

Entertainment

7.5

Food

7.0

Boarding

8.1

Crew

8.6

Reviews

1 / 20
8.0
Excellent

Walter,Aug 2025

OAK - SAN

Dozens of flights and I've never seen a row's beverages forgotten. I even went back and asked the attendant to check on them and nothing. I really hope it didn't have something to do with the Black mother with her kid in the row. Otherwise it was a typical Southwest flight, rapid boarding, tolerable leg room.
American Airlines
7.2
Good
11,032 reviews
Southwest
8.0
Very good
4,241 reviews

Overall

8.0

Comfort

8.0

Entertainment

7.5

Food

7.0

Boarding

8.1

Crew

8.6

Reviews

1 / 20
8.0
Excellent

Walter,Aug 2025

OAK - SAN

Dozens of flights and I've never seen a row's beverages forgotten. I even went back and asked the attendant to check on them and nothing. I really hope it didn't have something to do with the Black mother with her kid in the row. Otherwise it was a typical Southwest flight, rapid boarding, tolerable leg room.

Related info for your journey

Find useful and relevant information for your journey from Panama City to San Diego. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • How long is the flight from Panama City, Florida to San Diego?

    Southwest, Delta, and American Airlines can get you from Panama City, Florida to San Diego in just under 8h 01m. Your travel time can differ by up to 1h 19m. There are 1848 mi between Panama City, Florida and San Diego. Both multi-stop and nonstop flights can be found to your destination and back.

  • What are the cheapest airlines flying from Panama City, Florida to San Diego round-trip?

    Cheapflights users have booked flights from Panama City, Florida to San Diego round-trip from $296. Other airlines that can offer you cheap pricing are Southwest, from $316, and American Airlines, from $326. Delta is 37% cheaper than the average price of flights available within the next 90 days to this destination.

  • What are the cheapest airlines to fly from Panama City, Florida to San Diego one-way?

    The cheapest airline one-way is American Airlines, with whom users have recently found tickets for as low as $176. However, be on the lookout for offers from United Airlines and Delta, as they are both options that can get you from Panama City, Florida to San Diego for a low price.

  • Can I find deals for flights from Panama City to San Diego that include hotel bookings?

    Yes. In addition to deals on Panama City to San Diego flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Panama City to San Diego?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Panama City to San Diego.

  • Can I find deals for business class flights from Panama City to San Diego?

    Yes. Cheapflights offers flight deals from Panama City to San Diego by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Panama City, Florida to San Diego?

    Currently, November is the cheapest month in which you can book a flight from Panama City, Florida to San Diego (average of $108). Flying from Panama City, Florida to San Diego in July is currently the most expensive (average of $306). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Traveling to a place near San Diego?

Book flights to San Diego if you plan to visit one of these locations
El Cajon
Chula Vista
Coronado
La Mesa
Poway
Lemon Grove
National City

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Top 4 airlines flying from Panama City to San Diego

Discover the top 4 airlines that operate flights from Panama City to San Diego. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated October 29, 2025.
AirlineCheapestAverageFlexibilityOn-time
DeltaCheapest$296Average$410FlexibilityNo cancel feeOn-timeN/A
SouthwestCheapest$316Average$546FlexibilityNo cancel feeOn-time63%
American AirlinesCheapest$326Average$416FlexibilityNo cancel feeOn-time71%
United AirlinesCheapest$354Average$486FlexibilityNo cancel feeOn-time69%

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