HomeSearch by dateVacation packagesHotelsFlight dealsCar rentalTravel tips & news
San Diego

$219+ Cheap flights from Panama City, FL to San Diego (ECP - SAN)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 5/15. Fares are subject to change and may not be available on all flights or dates of travel.
ECP — SAN
Apr 10 — Apr 171
Fri 4/10
Fri 4/17
1 adult, Economy
We work with more than 300 partners to bring you better travel deals

Find cheap flights from Panama City to San Diego with Cheapflights

1. Tell us where you want to go

Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”

2. Select your favorite providers

We find the providers serving your travel needs. Choose up to four travel providers to compare side-by-side for flights, hotels, or car rentals.

3. Compare prices and book

Review each provider’s pricing and select the best option for you! Book through your favorite provider’s website for a seamless experience.

Cheap flight deals from Panama City to San Diego

Cheapest flights from Panama City to San Diego
Explore the most affordable flight options available from Panama City to San Diego. Find the lowest fares from popular airlines and budget airlines, with prices last updated on March 11, 2026.

This Delta deal was found by Cheapflights users on 3/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 4/85:30 pm
ECP
-
SAN
1 stop7h 39m
Delta
Tue 4/149:45 pm
SAN
-
ECP
1 stop8h 50m
Delta
Deal found 3/8$377
This Delta deal was found by Cheapflights users on 3/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 3/316:00 am
ECP
-
SAN
1 stop8h 58m
Delta
Tue 4/72:09 pm
SAN
-
ECP
1 stop6h 55m
Delta
Deal found 3/8$378
This United Airlines deal was found by Cheapflights users on 3/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 4/86:30 am
ECP
-
SAN
1 stop9h 21m
United Airlines
Mon 4/138:37 pm
SAN
-
ECP
2 stops10h 58m
United Airlines
Deal found 3/8$383
This American Airlines deal was found by Cheapflights users on 3/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 4/2510:48 am
ECP
-
SAN
1 stop10h 12m
American Airlines
Tue 4/2811:58 am
SAN
-
ECP
1 stop8h 54m
American Airlines
Deal found 3/9$398
This United Airlines deal was found by Cheapflights users on 3/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 7/2810:25 am
ECP
-
SAN
1 stop10h 07m
United Airlines
Sat 8/16:15 am
SAN
-
ECP
1 stop8h 08m
United Airlines
Deal found 3/7$407
This Southwest deal was found by Cheapflights users on 3/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 4/96:40 am
ECP
-
SAN
1 stop6h 05m
Southwest
Sun 4/126:55 am
SAN
-
ECP
1 stop7h 55m
Southwest
Deal found 3/10$408
This Southwest deal was found by Cheapflights users on 3/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 4/135:00 pm
ECP
-
SAN
1 stop8h 10m
Southwest
Fri 4/1710:45 am
SAN
-
ECP
2 stops8h 55m
Southwest
Deal found 3/6$413
This Southwest deal was found by Cheapflights users on 3/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 7/2810:25 am
ECP
-
SAN
2 stops9h 55m
Southwest
Sat 8/18:35 am
SAN
-
ECP
2 stops8h 25m
Southwest
Deal found 3/7$417
This United Airlines deal was found by Cheapflights users on 3/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 4/234:57 pm
ECP
-
SAN
2 stops9h 02m
United Airlines
Sun 4/268:37 pm
SAN
-
ECP
2 stops11h 11m
United Airlines
Deal found 3/9$418

Find flight deals from Panama City to San Diego

Discover tips and strategies to find the most affordable flight options for your journey from Panama City (ECP) to San Diego (SAN). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated March 11, 2026.

Most accurate provider

FlightHub
3 stars

Most trusted provider

FlightHub
3 stars

Round-trip from

$377
(Delta)

One-way from

$219
(Southwest)

Popular in

April

Cheapest in

May

Average price

$487
Provider with most accurate pricing for Panama City NW Florida Beaches-San Diego flight deals.
Search Deals
Provider most trusted by Cheapflights users for Panama City NW Florida Beaches-San Diego flights.
Search Deals
From Panama City NW Florida Beaches to San Diego
Search Deals
One-way flight from Panama City NW Florida Beaches to San Diego
Search Deals
Highest demand for flights based on searches. 3% potential increase in price ($15 potential increase over avg. RT price).
Search Deals
Cheapest flight prices on average. 2% potential price decrease ($10 potential savings vs. average RT price).
Search Deals
Average for round-trip flights in March 2026
Search Deals

Cheapflights Fare Finder

 
Customize your flight search to find flights from Panama City to San Diego that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated March 11, 2026.
Use the filters below to find and compare flights from Panama City to San Diego that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Cheapest round-trip

Panama CitySan Diego

ECP - SAN

ECPSAN

Panama City NW Florida Beaches

Mon 4/13

5:25 pm-10:55 pm

1 stop7h 30m

San Diego

Fri 4/17

6:20 am-4:50 pm

1 stop8h 30m

$408

Panama CitySan Diego

ECP - SAN

ECPSAN

Panama City NW Florida Beaches

Wed 9/2

9:10 am-2:40 pm

2 stops7h 30m

San Diego

Sat 9/12

10:40 pm-10:55 am

1 stop10h 15m

$412

Panama CitySan Diego

ECP - SAN

ECPSAN

Panama City NW Florida Beaches

Mon 4/13

4:57 pm-9:26 pm

1 stop6h 29m

San Diego

Fri 4/17

7:40 pm-9:35 am

2 stops11h 55m

$413

Panama CitySan Diego

ECP - SAN

ECPSAN

Panama City NW Florida Beaches

Mon 6/15

6:55 am-2:10 pm

2 stops9h 15m

San Diego

Sun 6/21

6:35 am-6:30 pm

1 stop9h 55m

$448
Quickest round-trip

Panama CitySan Diego

ECP - SAN

ECPSAN

Panama City NW Florida Beaches

Fri 5/22

5:00 pm-11:10 pm

1 stop8h 10m

San Diego

Fri 5/29

12:40 pm-9:30 pm

1 stop6h 50m

$457

Panama CitySan Diego

ECP - SAN

ECPSAN

Panama City NW Florida Beaches

Wed 4/15

10:19 am-6:51 pm

1 stop10h 32m

San Diego

Sat 4/18

12:10 pm-9:59 pm

1 stop7h 49m

$469

Panama CitySan Diego

ECP - SAN

ECPSAN

Panama City NW Florida Beaches

Sat 4/25

10:10 am-8:12 pm

2 stops12h 02m

San Diego

Tue 4/28

11:00 am-9:59 pm

2 stops8h 59m

$478
Cheapest one-way
Quickest one-way

Panama CitySan Diego

ECP - SAN

ECPSAN

Panama City NW Florida Beaches

Fri 5/15

2:50 pm-7:23 pm

1 stop6h 33m

$219

Panama CitySan Diego

ECP - SAN

ECPSAN

Panama City NW Florida Beaches

Thu 7/23

2:55 pm-9:20 pm

1 stop8h 25m

$219

Panama CitySan Diego

ECP - SAN

ECPSAN

Panama City NW Florida Beaches

Fri 5/15

7:10 am-3:35 pm

2 stops10h 25m

$234

Flights are sorted by cheapest round-trip flights first.

Deals found on 3/11

Showing 1-10 of 15 resultsSorted by cheapest first
1
2

Compare providers for flights from Panama City to San Diego

Provider information is updated monthly. Please note that these providers often have deals for this flight, but the availability may vary on a day-by-day basis on Cheapflights.
Use the table below to compare price accuracy, trust ratings, and cancellation policies for each provider offering flight deals from Panama City to San Diego in March.
ProviderPrice AccuracyTrust Score*
ExpediaPrice Accuracy1 starTrust Score*3 stars
FlightHubPrice Accuracy3 starsTrust Score*3 stars
PricelinePrice Accuracy1 starTrust Score*3 stars

*The Trust Score is based on feedback from users after their booking experience. It measures overall satisfaction, helping us identify issues like hidden fees, problems during the ticketing process, and the quality of customer service. This score is our best indicator of the provider's quality and reliability.

  • Most accurate provider: When it comes to deals on Panama City, Florida-San Diego flights, users find the pricing of FlightHub to be most consistent on Cheapflights vs. FlightHub Users can find the same prices on Panama City, Florida-San Diego flight deals on Cheapflights vs. FlightHub >95% of the time. Price accuracy is based on data collected from Panama City, Florida-San Diego flight searches over the past month and is updated monthly.
  • Most trusted provider: When it comes to deals on Panama City, Florida-San Diego flights, Cheapflights users trust FlightHub the most. FlightHub has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for Panama City, Florida-San Diego flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.

Best time to book a flight from Panama City to San Diego

Have a flexible travel schedule? Discover the best time to fly to San Diego from Panama City with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Panama City to San Diego

What is the cheapest month to book a flight from Panama City, Florida to San Diego?

Currently, June is the cheapest month in which you can book a flight from Panama City, Florida to San Diego (average of $122). Flying from Panama City, Florida to San Diego in July is currently the most expensive (average of $299). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

How much does it cost to fly round-trip from Panama City, Florida to San Diego?

Reviews of airlines servicing San Diego

Get insights into the airlines that provide service to San Diego. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to San Diego. Reviews last updated March 11, 2026.
Read through reviews of airlines operating flights from Panama City to San Diego, such as Southwest,Delta, andUnited Airlines. Reviews also offer insight into each airline's entertainment options, comfort, food, crew/service, and boarding process.
Southwest
8.0
Very good
4,317 reviews

Crew

8.6

Comfort

8.0

Entertainment

7.5

Overall

8.0

Boarding

8.1

Food

7.0

Reviews

1 / 20
8.0
Excellent

Walter,Aug 2025

OAK - SAN

Dozens of flights and I've never seen a row's beverages forgotten. I even went back and asked the attendant to check on them and nothing. I really hope it didn't have something to do with the Black mother with her kid in the row. Otherwise it was a typical Southwest flight, rapid boarding, tolerable leg room.
Southwest
8.0
Very good
4,317 reviews
Southwest
8.0
Very good
4,317 reviews

Crew

8.6

Comfort

8.0

Entertainment

7.5

Overall

8.0

Boarding

8.1

Food

7.0

Reviews

1 / 20
8.0
Excellent

Walter,Aug 2025

OAK - SAN

Dozens of flights and I've never seen a row's beverages forgotten. I even went back and asked the attendant to check on them and nothing. I really hope it didn't have something to do with the Black mother with her kid in the row. Otherwise it was a typical Southwest flight, rapid boarding, tolerable leg room.
Delta
7.9
Good
8,278 reviews
Southwest
8.0
Very good
4,317 reviews

Crew

8.6

Comfort

8.0

Entertainment

7.5

Overall

8.0

Boarding

8.1

Food

7.0

Reviews

1 / 20
8.0
Excellent

Walter,Aug 2025

OAK - SAN

Dozens of flights and I've never seen a row's beverages forgotten. I even went back and asked the attendant to check on them and nothing. I really hope it didn't have something to do with the Black mother with her kid in the row. Otherwise it was a typical Southwest flight, rapid boarding, tolerable leg room.
United Airlines
7.4
Good
9,414 reviews
Southwest
8.0
Very good
4,317 reviews

Crew

8.6

Comfort

8.0

Entertainment

7.5

Overall

8.0

Boarding

8.1

Food

7.0

Reviews

1 / 20
8.0
Excellent

Walter,Aug 2025

OAK - SAN

Dozens of flights and I've never seen a row's beverages forgotten. I even went back and asked the attendant to check on them and nothing. I really hope it didn't have something to do with the Black mother with her kid in the row. Otherwise it was a typical Southwest flight, rapid boarding, tolerable leg room.
American Airlines
7.1
Good
11,419 reviews
Southwest
8.0
Very good
4,317 reviews

Crew

8.6

Comfort

8.0

Entertainment

7.5

Overall

8.0

Boarding

8.1

Food

7.0

Reviews

1 / 20
8.0
Excellent

Walter,Aug 2025

OAK - SAN

Dozens of flights and I've never seen a row's beverages forgotten. I even went back and asked the attendant to check on them and nothing. I really hope it didn't have something to do with the Black mother with her kid in the row. Otherwise it was a typical Southwest flight, rapid boarding, tolerable leg room.

Related info for your journey

Find useful and relevant information for your journey from Panama City to San Diego. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • How long is the flight from Panama City, Florida to San Diego?

    Delta and United Airlines can get you from Panama City, Florida to San Diego in just under 7h 39m. Your travel time can differ by up to 3h 30m. There are 1848 mi between Panama City, Florida and San Diego. Both multi-stop and nonstop flights can be found to your destination and back.

  • What are the cheapest airlines flying from Panama City, Florida to San Diego round-trip?

    Cheapflights users have booked flights from Panama City, Florida to San Diego round-trip from $209. Other airlines that can offer you cheap pricing are United Airlines, from $256, and Southwest, from $260. Delta is 51% cheaper than the average price of flights available within the next 90 days to this destination.

  • Can I find deals for flights from Panama City to San Diego that include hotel bookings?

    Yes. In addition to deals on Panama City to San Diego flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Panama City to San Diego?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Panama City to San Diego.

  • Can I find deals for business class flights from Panama City to San Diego?

    Yes. Cheapflights offers flight deals from Panama City to San Diego by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Panama City, Florida to San Diego?

    Currently, June is the cheapest month in which you can book a flight from Panama City, Florida to San Diego (average of $122). Flying from Panama City, Florida to San Diego in July is currently the most expensive (average of $299). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Traveling to a place near San Diego?

Book flights to San Diego if you plan to visit one of these locations
El Cajon
Chula Vista
National City
Coronado
La Mesa
Poway
Julian
Lemon Grove

Browse thousands of different options on Cheapflights for your next trip

Toggle through the tabs below to find thousands of options on Cheapflights for your next trip.

Alternative routes for Panama City to San Diego

See prices for flight routes from nearby airports that may be better suited for you.
Orlando to Las Vegas flights
Orlando to Los Angeles flights
Fort Lauderdale to Las Vegas flights
Tampa to Las Vegas flights
Miami to Las Vegas flights
Miami to Los Angeles flights
Fort Lauderdale to Los Angeles flights
Tampa to Los Angeles flights
Miami to San Francisco flights
Orlando to San Francisco flights
Tampa to San Francisco flights
Fort Lauderdale to San Francisco flights
Orlando to Ontario flights
Fort Lauderdale to Burbank flights
Orlando to San Diego flights
West Palm Beach to Las Vegas flights
Miami to Ontario flights
Fort Myers to Las Vegas flights
Jacksonville to Las Vegas flights
Tampa to San Diego flights
Fort Lauderdale to Santa Ana flights
Fort Lauderdale to Ontario flights
Pensacola to Las Vegas flights
Miami to San Diego flights
West Palm Beach to Los Angeles flights
Orlando to Burbank flights
Tampa to Ontario flights
Orlando to Santa Ana flights
Fort Lauderdale to San Diego flights
West Palm Beach to San Francisco flights
Jacksonville to Los Angeles flights
Fort Myers to Los Angeles flights
Tampa to Santa Ana flights
Orlando to Sacramento flights
Fort Myers to San Francisco flights
Jacksonville to San Francisco flights
Pensacola to Los Angeles flights
Jacksonville to San Diego flights
Sarasota to Las Vegas flights
Jacksonville to Ontario flights
Miami to Burbank flights
West Palm Beach to Ontario flights
Panama City to Las Vegas flights
Tampa to Reno flights
Orlando to Reno flights
Tampa to San Jose flights
Orlando to San Jose flights
Tampa to Sacramento flights
Miami to Palm Springs flights

Top 4 airlines flying from Panama City to San Diego

Discover the top 4 airlines that operate flights from Panama City to San Diego. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated March 11, 2026.
AirlineCheapestAverageFlexibilityOn-time
DeltaCheapest$209Average$376FlexibilityNo cancel feeOn-timeN/A
United AirlinesCheapest$256Average$406FlexibilityNo cancel feeOn-time69%
SouthwestCheapest$260Average$457FlexibilityNo cancel feeOn-time63%
American AirlinesCheapest$306Average$436FlexibilityNo cancel feeOn-time71%

100% Free

Cheapflights is completely free to use, so you can start saving the moment you arrive.

Book with Flexibility

Our users can plan ahead with confidence and find flights with no change fees

Travel Smart

Millions of people come to us for their flight needs every year. We help make travel planning easy by providing useful insights and data-driven graphs that can inform your decisions.