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$187+ Cheap flights from Myrtle Beach to San Diego (MYR - SAN)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 3/23. Fares are subject to change and may not be available on all flights or dates of travel.
MYR — SAN
Feb 25 — Mar 41
Wed 2/25
Wed 3/4
1 adult, Economy
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Cheap flight deals from Myrtle Beach to San Diego

Cheapest flights from Myrtle Beach to San Diego
Explore the most affordable flight options available from Myrtle Beach to San Diego. Find the lowest fares from popular airlines and budget airlines, with prices last updated on January 26, 2026.

This American Airlines deal was found by Cheapflights users on 1/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 2/133:17 pm
MYR
-
SAN
1 stop8h 50m
American Airlines
Mon 2/1610:43 pm
SAN
-
MYR
1 stop7h 53m
American Airlines
Deal found 1/26$359
This Southwest deal was found by Cheapflights users on 1/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 2/191:20 pm
MYR
-
SAN
2 stops9h 40m
Southwest
Mon 2/238:25 pm
SAN
-
MYR
2 stops10h 50m
Southwest
Deal found 1/24$369
This American Airlines deal was found by Cheapflights users on 1/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 2/1412:43 pm
MYR
-
SAN
2 stops10h 31m
American Airlines
Wed 2/187:42 pm
SAN
-
MYR
2 stops9h 58m
American Airlines
Deal found 1/25$370
This American Airlines deal was found by Cheapflights users on 1/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 2/1412:43 pm
MYR
-
SAN
2 stops10h 31m
American Airlines
Tue 2/176:20 am
SAN
-
MYR
1 stop7h 13m
American Airlines
Deal found 1/25$374
This American Airlines deal was found by Cheapflights users on 1/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 2/263:17 pm
MYR
-
SAN
1 stop8h 50m
American Airlines
Mon 3/27:42 pm
SAN
-
MYR
2 stops10h 54m
American Airlines
Deal found 1/24$376
This Southwest deal was found by Cheapflights users on 1/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 2/1710:35 am
MYR
-
SAN
2 stops11h 45m
Southwest
Thu 2/198:25 pm
SAN
-
MYR
2 stops10h 30m
Southwest
Deal found 1/26$378
This American Airlines deal was found by Cheapflights users on 1/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 3/101:58 pm
MYR
-
SAN
1 stop7h 29m
American Airlines
Thu 3/1210:43 pm
SAN
-
MYR
1 stop6h 49m
American Airlines
Deal found 1/24$389
This American Airlines deal was found by Cheapflights users on 1/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 2/133:17 pm
MYR
-
SAN
1 stop8h 50m
American Airlines
Tue 2/176:24 am
SAN
-
MYR
2 stops11h 21m
American Airlines
Deal found 1/24$395
This Southwest deal was found by Cheapflights users on 1/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 3/2410:40 am
MYR
-
SAN
2 stops11h 50m
Southwest
Tue 3/316:50 am
SAN
-
MYR
2 stops11h 20m
Southwest
Deal found 1/25$399

Find flight deals from Myrtle Beach to San Diego

Discover tips and strategies to find the most affordable flight options for your journey from Myrtle Beach (MYR) to San Diego (SAN). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated January 26, 2026.

Most accurate provider

FlightHub
3 stars

Most trusted provider

FlightHub
3 stars

Round-trip from

$359
(American Airlines)

One-way from

$187
(Kiwi.com)

Popular in

December

Cheapest in

September

Average price

$552
Provider with most accurate pricing for Myrtle Beach Intl-San Diego flight deals.
Search Deals
Provider most trusted by Cheapflights users for Myrtle Beach Intl-San Diego flights.
Search Deals
From Myrtle Beach Intl to San Diego
Search Deals
One-way flight from Myrtle Beach Intl to San Diego
Search Deals
Highest demand for flights based on searches. 13% potential increase in price ($80 potential increase over avg. RT price).
Search Deals
Cheapest flight prices on average. 2% potential price decrease ($12 potential savings vs. average RT price).
Search Deals
Average for round-trip flights in January 2026
Search Deals

Cheapflights Fare Finder

 
Customize your flight search to find flights from Myrtle Beach to San Diego that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated January 26, 2026.
Use the filters below to find and compare flights from Myrtle Beach to San Diego that are best for you.

Fly from

Myrtle Beach

Fly to

San Diego

Route

Depart

Return

Price

Myrtle BeachSan Diego

MYR - SAN

MYRSAN

Myrtle Beach Intl

Sat 2/14

5:18 pm-10:30 pm

1 stop8h 12m

San Diego

Wed 2/18

6:20 am-4:33 pm

1 stop7h 13m

$359

Myrtle BeachSan Diego

MYR - SAN

MYRSAN

Myrtle Beach Intl

Sat 2/14

4:00 pm-10:48 pm

1 stop9h 48m

San Diego

Tue 2/17

10:20 pm-9:45 am

1 stop8h 25m

$359

Myrtle BeachSan Diego

MYR - SAN

MYRSAN

Myrtle Beach Intl

Fri 2/13

3:17 pm-9:07 pm

1 stop8h 50m

San Diego

Tue 2/17

11:56 am-10:56 pm

1 stop8h 00m

$359

Myrtle BeachSan Diego

MYR - SAN

MYRSAN

Myrtle Beach Intl

Tue 2/17

6:01 am-10:57 am

1 stop7h 56m

San Diego

Thu 2/19

12:09 pm-11:55 pm

1 stop8h 46m

$359

Myrtle BeachSan Diego

MYR - SAN

MYRSAN

Myrtle Beach Intl

Thu 2/19

1:20 pm-8:00 pm

2 stops9h 40m

San Diego

Mon 2/23

9:45 pm-10:15 am

1 stop9h 30m

$364

Myrtle BeachSan Diego

MYR - SAN

MYRSAN

Myrtle Beach Intl

Fri 2/13

6:23 pm-10:59 pm

1 stop7h 36m

San Diego

Mon 2/16

7:42 pm-9:36 am

2 stops10h 54m

$364

Myrtle BeachSan Diego

MYR - SAN

MYRSAN

Myrtle Beach Intl

Sat 2/14

12:43 pm-8:14 pm

2 stops10h 31m

San Diego

Tue 2/17

6:20 am-4:33 pm

1 stop7h 13m

$374

Myrtle BeachSan Diego

MYR - SAN

MYRSAN

Myrtle Beach Intl

Tue 2/17

10:35 am-7:20 pm

2 stops11h 45m

San Diego

Thu 2/19

8:25 pm-9:55 am

2 stops10h 30m

$378

Myrtle BeachSan Diego

MYR - SAN

MYRSAN

Myrtle Beach Intl

Mon 3/2

3:17 pm-9:07 pm

1 stop8h 50m

San Diego

Tue 3/10

7:52 pm-8:32 am

2 stops9h 40m

$379

Myrtle BeachSan Diego

MYR - SAN

MYRSAN

Myrtle Beach Intl

Thu 2/12

5:18 pm-11:59 pm

1 stop9h 41m

San Diego

Sun 2/15

10:43 pm-8:40 am

1 stop6h 57m

$389

Flights are sorted by cheapest round-trip flights first.

Deals found on 1/25

Showing 1-10 of 13 results
1
2

Compare providers for flights from Myrtle Beach to San Diego

Provider information is updated monthly. Please note that these providers often have deals for this flight, but the availability may vary on a day-by-day basis on Cheapflights.
Use the table below to compare price accuracy, trust ratings, and cancellation policies for each provider offering flight deals from Myrtle Beach to San Diego in January.
ProviderPrice AccuracyTrust Score*
ExpediaPrice Accuracy1 starTrust Score*3 stars
FlightHubPrice Accuracy3 starsTrust Score*3 stars

*The Trust Score is based on feedback from users after their booking experience. It measures overall satisfaction, helping us identify issues like hidden fees, problems during the ticketing process, and the quality of customer service. This score is our best indicator of the provider's quality and reliability.

  • Most accurate provider: When it comes to deals on Myrtle Beach-San Diego flights, users find the pricing of FlightHub to be most consistent on Cheapflights vs. FlightHub Users can find the same prices on Myrtle Beach-San Diego flight deals on Cheapflights vs. FlightHub >95% of the time. Price accuracy is based on data collected from Myrtle Beach-San Diego flight searches over the past month and is updated monthly.
  • Most trusted provider: When it comes to deals on Myrtle Beach-San Diego flights, Cheapflights users trust FlightHub the most. FlightHub has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for Myrtle Beach-San Diego flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.

Best time to book a flight from Myrtle Beach to San Diego

Have a flexible travel schedule? Discover the best time to fly to San Diego from Myrtle Beach with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Myrtle Beach to San Diego

What is the cheapest month to book a flight from Myrtle Beach to San Diego?

Currently, September is the cheapest month in which you can book a flight from Myrtle Beach to San Diego (average of $165). Flying from Myrtle Beach to San Diego in August is currently the most expensive (average of $284). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

Reviews of airlines servicing San Diego

Get insights into the airlines that provide service to San Diego. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to San Diego. Reviews last updated January 26, 2026.
Get a feel of what it's like to fly with Southwest, Delta, and American Airlines from Myrtle Beach to San Diego by reading reviews from past customers. Users have also rated airlines in terms of entertainment options, comfort, food, crew/service, and boarding process.
Southwest
8.0
Very good
4,268 reviews

Crew

8.6

Boarding

8.1

Comfort

8.0

Entertainment

7.5

Overall

8.0

Food

7.0

Reviews

1 / 20
8.0
Excellent

Walter,Aug 2025

OAK - SAN

Dozens of flights and I've never seen a row's beverages forgotten. I even went back and asked the attendant to check on them and nothing. I really hope it didn't have something to do with the Black mother with her kid in the row. Otherwise it was a typical Southwest flight, rapid boarding, tolerable leg room.
Southwest
8.0
Very good
4,268 reviews
Southwest
8.0
Very good
4,268 reviews

Crew

8.6

Boarding

8.1

Comfort

8.0

Entertainment

7.5

Overall

8.0

Food

7.0

Reviews

1 / 20
8.0
Excellent

Walter,Aug 2025

OAK - SAN

Dozens of flights and I've never seen a row's beverages forgotten. I even went back and asked the attendant to check on them and nothing. I really hope it didn't have something to do with the Black mother with her kid in the row. Otherwise it was a typical Southwest flight, rapid boarding, tolerable leg room.
Delta
7.9
Good
8,111 reviews
Southwest
8.0
Very good
4,268 reviews

Crew

8.6

Boarding

8.1

Comfort

8.0

Entertainment

7.5

Overall

8.0

Food

7.0

Reviews

1 / 20
8.0
Excellent

Walter,Aug 2025

OAK - SAN

Dozens of flights and I've never seen a row's beverages forgotten. I even went back and asked the attendant to check on them and nothing. I really hope it didn't have something to do with the Black mother with her kid in the row. Otherwise it was a typical Southwest flight, rapid boarding, tolerable leg room.
American Airlines
7.2
Good
11,189 reviews
Southwest
8.0
Very good
4,268 reviews

Crew

8.6

Boarding

8.1

Comfort

8.0

Entertainment

7.5

Overall

8.0

Food

7.0

Reviews

1 / 20
8.0
Excellent

Walter,Aug 2025

OAK - SAN

Dozens of flights and I've never seen a row's beverages forgotten. I even went back and asked the attendant to check on them and nothing. I really hope it didn't have something to do with the Black mother with her kid in the row. Otherwise it was a typical Southwest flight, rapid boarding, tolerable leg room.

Related info for your journey

Find useful and relevant information for your journey from Myrtle Beach to San Diego. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • How long is the flight from Myrtle Beach to San Diego?

    There are many flights that can get you from Myrtle Beach to San Diego in 8h 12m. Fly via American Airlines, Delta, or Southwest to get the fastest option. Myrtle Beach and San Diego are separated by a distance of 2199 mi. Both multi-stop and nonstop flights can be found to your destination and back.

  • What are the cheapest airlines flying from Myrtle Beach to San Diego round-trip?

    Cheapflights users have booked flights from Myrtle Beach to San Diego round-trip from $274. Other airlines that can offer you cheap pricing are Delta, from $331, and Southwest, from $437. American Airlines is currently priced 44% below the average price you’ll pay for this route.

  • What are the cheapest airlines to fly from Myrtle Beach to San Diego one-way?

    To fly one-way, consider booking your trip with American Airlines, which is currently one of the cheapest options available, starting at $162. Delta flights start at $167 while deals on Southwest start at $206 one-way.

  • Can I find deals for flights from Myrtle Beach to San Diego that include hotel bookings?

    Yes. In addition to deals on Myrtle Beach to San Diego flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Myrtle Beach to San Diego?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Myrtle Beach to San Diego.

  • Can I find deals for business class flights from Myrtle Beach to San Diego?

    Yes. Cheapflights offers flight deals from Myrtle Beach to San Diego by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Myrtle Beach to San Diego?

    Currently, September is the cheapest month in which you can book a flight from Myrtle Beach to San Diego (average of $165). Flying from Myrtle Beach to San Diego in August is currently the most expensive (average of $284). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Traveling to a place near San Diego?

Book flights to San Diego if you plan to visit one of these locations
El Cajon
Chula Vista
National City
Coronado
La Mesa
Poway
Julian
Lemon Grove

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Top 3 airlines flying from Myrtle Beach to San Diego

Discover the top 3 airlines that operate flights from Myrtle Beach to San Diego. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated January 26, 2026.
AirlineCheapestAverageFlexibilityOn-time
American AirlinesCheapest$274Average$452FlexibilityNo cancel feeOn-time71%
DeltaCheapest$331Average$497FlexibilityNo cancel feeOn-timeN/A
SouthwestCheapest$437Average$476FlexibilityNo cancel feeOn-time63%

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