HomeSearch by dateVacation packagesHotelsFlight dealsCar rentalTravel tips & news
San Diego

$158+ Cheap flights from Myrtle Beach to San Diego (MYR - SAN)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 3/30. Fares are subject to change and may not be available on all flights or dates of travel.
MYR — SAN
Apr 12 — Apr 191
Sun 4/12
Sun 4/19
1 adult, Economy
We work with more than 300 partners to bring you better travel deals

Find cheap flights from Myrtle Beach to San Diego with Cheapflights

1. Tell us where you want to go

Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”

2. Select your favorite providers

We find the providers serving your travel needs. Choose up to four travel providers to compare side-by-side for flights, hotels, or car rentals.

3. Compare prices and book

Review each provider’s pricing and select the best option for you! Book through your favorite provider’s website for a seamless experience.

Cheap flight deals from Myrtle Beach to San Diego

Cheapest flights from Myrtle Beach to San Diego
Explore the most affordable flight options available from Myrtle Beach to San Diego. Find the lowest fares from popular airlines and budget airlines, with prices last updated on March 13, 2026.

This United Airlines deal was found by Cheapflights users on 3/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 5/1211:30 am
MYR
-
SAN
1 stop10h 11m
United Airlines
Sat 5/1610:40 pm
SAN
-
MYR
1 stop9h 02m
United Airlines
Deal found 3/11$382
This American Airlines deal was found by Cheapflights users on 3/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 4/15:19 pm
MYR
-
SAN
1 stop9h 40m
American Airlines
Mon 4/610:43 pm
SAN
-
MYR
1 stop8h 02m
American Airlines
Deal found 3/9$392
This Southwest deal was found by Cheapflights users on 3/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 3/315:20 pm
MYR
-
SAN
1 stop7h 45m
Southwest
Mon 4/610:40 pm
SAN
-
MYR
1 stop11h 50m
Southwest
Deal found 3/10$397
This American Airlines deal was found by Cheapflights users on 3/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 4/151:57 pm
MYR
-
SAN
1 stop9h 53m
American Airlines
Sun 4/1910:40 pm
SAN
-
MYR
1 stop10h 24m
American Airlines
Deal found 3/10$407
This Southwest deal was found by Cheapflights users on 3/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 6/42:05 pm
MYR
-
SAN
2 stops12h 20m
Southwest
Tue 6/97:50 am
SAN
-
MYR
2 stops10h 15m
Southwest
Deal found 3/9$408
This United Airlines deal was found by Cheapflights users on 3/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 4/111:00 am
MYR
-
SAN
2 stops12h 05m
United Airlines
Mon 4/68:37 pm
SAN
-
MYR
2 stops10h 41m
United Airlines
Deal found 3/9$412
This American Airlines deal was found by Cheapflights users on 3/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 3/316:01 am
MYR
-
SAN
1 stop10h 27m
American Airlines
Sat 4/41:37 pm
SAN
-
MYR
1 stop7h 18m
American Airlines
Deal found 3/10$416
This American Airlines deal was found by Cheapflights users on 3/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 4/25:19 pm
MYR
-
SAN
1 stop9h 40m
American Airlines
Tue 4/711:58 am
SAN
-
MYR
1 stop6h 58m
American Airlines
Deal found 3/10$420
This American Airlines deal was found by Cheapflights users on 3/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 4/274:52 pm
MYR
-
SAN
1 stop8h 08m
American Airlines
Thu 4/309:45 pm
SAN
-
MYR
1 stop7h 39m
American Airlines
Deal found 3/11$425

Find flight deals from Myrtle Beach to San Diego

Discover tips and strategies to find the most affordable flight options for your journey from Myrtle Beach (MYR) to San Diego (SAN). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated March 13, 2026.

Most accurate provider

FlightHub
3 stars

Most trusted provider

FlightHub
3 stars

Round-trip from

$382
(United Airlines)

One-way from

$158
(Kiwi.com)

Popular in

December

Cheapest in

September

Average price

$529
Provider with most accurate pricing for Myrtle Beach Intl-San Diego flight deals.
Search Deals
Provider most trusted by Cheapflights users for Myrtle Beach Intl-San Diego flights.
Search Deals
From Myrtle Beach Intl to San Diego
Search Deals
One-way flight from Myrtle Beach Intl to San Diego
Search Deals
Highest demand for flights based on searches. 15% potential increase in price ($87 potential increase over avg. RT price).
Search Deals
Cheapest flight prices on average. 2% potential price decrease ($13 potential savings vs. average RT price).
Search Deals
Average for round-trip flights in March 2026
Search Deals

Cheapflights Fare Finder

 
Customize your flight search to find flights from Myrtle Beach to San Diego that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated March 13, 2026.
Use the filters below to find and compare flights from Myrtle Beach to San Diego that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Cheapest round-trip

Myrtle BeachSan Diego

MYR - SAN

MYRSAN

Myrtle Beach Intl

Tue 5/12

11:30 am-8:14 pm

2 stops11h 44m

San Diego

Sat 5/16

6:26 pm-10:42 am

2 stops13h 16m

$392

Myrtle BeachSan Diego

MYR - SAN

MYRSAN

Myrtle Beach Intl

Wed 4/1

3:15 pm-10:59 pm

1 stop10h 44m

San Diego

Mon 4/6

8:37 pm-10:18 am

2 stops10h 41m

$407

Myrtle BeachSan Diego

MYR - SAN

MYRSAN

Myrtle Beach Intl

Thu 6/4

2:05 pm-11:25 pm

2 stops12h 20m

San Diego

Tue 6/9

7:50 am-9:05 pm

2 stops10h 15m

$408

Myrtle BeachSan Diego

MYR - SAN

MYRSAN

Myrtle Beach Intl

Wed 4/15

9:14 am-1:14 pm

1 stop7h 00m

San Diego

Sun 4/19

10:40 pm-12:04 pm

1 stop10h 24m

$417

Myrtle BeachSan Diego

MYR - SAN

MYRSAN

Myrtle Beach Intl

Thu 4/30

1:45 pm-7:00 pm

1 stop8h 15m

San Diego

Mon 5/4

9:40 pm-10:35 am

1 stop9h 55m

$417
Quickest round-trip

Myrtle BeachSan Diego

MYR - SAN

MYRSAN

Myrtle Beach Intl

Fri 5/15

11:32 am-6:01 pm

1 stop9h 29m

San Diego

Sun 5/17

1:55 pm-11:57 pm

1 stop7h 02m

$447

Myrtle BeachSan Diego

MYR - SAN

MYRSAN

Myrtle Beach Intl

Sat 8/29

3:21 pm-10:10 pm

1 stop9h 49m

San Diego

Tue 9/1

10:40 pm-10:39 am

1 stop8h 59m

$447

Myrtle BeachSan Diego

MYR - SAN

MYRSAN

Myrtle Beach Intl

Mon 5/11

3:20 pm-8:39 pm

1 stop8h 19m

San Diego

Sat 5/16

10:30 pm-10:39 am

1 stop9h 09m

$452

Myrtle BeachSan Diego

MYR - SAN

MYRSAN

Myrtle Beach Intl

Sun 8/2

5:45 pm-10:35 pm

1 stop7h 50m

San Diego

Thu 8/6

6:35 am-7:40 pm

1 stop10h 05m

$457

Myrtle BeachSan Diego

MYR - SAN

MYRSAN

Myrtle Beach Intl

Sat 6/20

3:50 pm-10:15 pm

1 stop9h 25m

San Diego

Sat 6/27

6:50 am-6:10 pm

2 stops8h 20m

$458

Flights are sorted by cheapest round-trip flights first.

Deals found on 3/12

Showing 1-10 of 20 resultsSorted by cheapest first
1
2

Compare providers for flights from Myrtle Beach to San Diego

Provider information is updated monthly. Please note that these providers often have deals for this flight, but the availability may vary on a day-by-day basis on Cheapflights.
Use the table below to compare price accuracy, trust ratings, and cancellation policies for each provider offering flight deals from Myrtle Beach to San Diego in March.
ProviderPrice AccuracyTrust Score*
ExpediaPrice Accuracy1 starTrust Score*3 stars
FlightHubPrice Accuracy3 starsTrust Score*3 stars

*The Trust Score is based on feedback from users after their booking experience. It measures overall satisfaction, helping us identify issues like hidden fees, problems during the ticketing process, and the quality of customer service. This score is our best indicator of the provider's quality and reliability.

  • Most accurate provider: When it comes to deals on Myrtle Beach-San Diego flights, users find the pricing of FlightHub to be most consistent on Cheapflights vs. FlightHub Users can find the same prices on Myrtle Beach-San Diego flight deals on Cheapflights vs. FlightHub >95% of the time. Price accuracy is based on data collected from Myrtle Beach-San Diego flight searches over the past month and is updated monthly.
  • Most trusted provider: When it comes to deals on Myrtle Beach-San Diego flights, Cheapflights users trust FlightHub the most. FlightHub has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for Myrtle Beach-San Diego flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.

Best time to book a flight from Myrtle Beach to San Diego

Have a flexible travel schedule? Discover the best time to fly to San Diego from Myrtle Beach with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Myrtle Beach to San Diego

What is the cheapest month to book a flight from Myrtle Beach to San Diego?

Currently, September is the cheapest month in which you can book a flight from Myrtle Beach to San Diego (average of $165). Flying from Myrtle Beach to San Diego in March is currently the most expensive (average of $294). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

Reviews of airlines servicing San Diego

Get insights into the airlines that provide service to San Diego. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to San Diego. Reviews last updated March 13, 2026.
Get a feel of what it's like to fly with Southwest,Delta, andAmerican Airlines from Myrtle Beach to San Diego by reading reviews from past customers. Users have also rated airlines in terms of entertainment options, comfort, food, crew/service, and boarding process.
Southwest
8.0
Very good
4,319 reviews

Comfort

8.0

Overall

8.0

Boarding

8.1

Crew

8.6

Entertainment

7.5

Food

7.0

Reviews

1 / 20
8.0
Excellent

Walter,Aug 2025

OAK - SAN

Dozens of flights and I've never seen a row's beverages forgotten. I even went back and asked the attendant to check on them and nothing. I really hope it didn't have something to do with the Black mother with her kid in the row. Otherwise it was a typical Southwest flight, rapid boarding, tolerable leg room.
Southwest
8.0
Very good
4,319 reviews
Southwest
8.0
Very good
4,319 reviews

Comfort

8.0

Overall

8.0

Boarding

8.1

Crew

8.6

Entertainment

7.5

Food

7.0

Reviews

1 / 20
8.0
Excellent

Walter,Aug 2025

OAK - SAN

Dozens of flights and I've never seen a row's beverages forgotten. I even went back and asked the attendant to check on them and nothing. I really hope it didn't have something to do with the Black mother with her kid in the row. Otherwise it was a typical Southwest flight, rapid boarding, tolerable leg room.
Delta
7.9
Good
8,285 reviews
Southwest
8.0
Very good
4,319 reviews

Comfort

8.0

Overall

8.0

Boarding

8.1

Crew

8.6

Entertainment

7.5

Food

7.0

Reviews

1 / 20
8.0
Excellent

Walter,Aug 2025

OAK - SAN

Dozens of flights and I've never seen a row's beverages forgotten. I even went back and asked the attendant to check on them and nothing. I really hope it didn't have something to do with the Black mother with her kid in the row. Otherwise it was a typical Southwest flight, rapid boarding, tolerable leg room.
American Airlines
7.1
Good
11,442 reviews
Southwest
8.0
Very good
4,319 reviews

Comfort

8.0

Overall

8.0

Boarding

8.1

Crew

8.6

Entertainment

7.5

Food

7.0

Reviews

1 / 20
8.0
Excellent

Walter,Aug 2025

OAK - SAN

Dozens of flights and I've never seen a row's beverages forgotten. I even went back and asked the attendant to check on them and nothing. I really hope it didn't have something to do with the Black mother with her kid in the row. Otherwise it was a typical Southwest flight, rapid boarding, tolerable leg room.

Related info for your journey

Find useful and relevant information for your journey from Myrtle Beach to San Diego. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • How long is the flight from Myrtle Beach to San Diego?

    There are many flights that can get you from Myrtle Beach to San Diego in 7h 45m. Fly via Southwest, United Airlines, or American Airlines to get the fastest option. Myrtle Beach and San Diego are separated by a distance of 2199 mi. Both multi-stop and nonstop flights can be found to your destination and back.

  • What are the cheapest airlines flying from Myrtle Beach to San Diego round-trip?

    Cheapflights users have booked flights from Myrtle Beach to San Diego round-trip from $274. Other airlines that can offer you cheap pricing are Delta, from $331, and Southwest, from $437. American Airlines is currently priced 43% below the average price you’ll pay for this route.

  • What are the cheapest airlines to fly from Myrtle Beach to San Diego one-way?

    To fly one-way, consider booking your trip with American Airlines, which is currently one of the cheapest options available, starting at $162. Delta flights start at $167 while deals on Southwest start at $206 one-way.

  • Can I find deals for flights from Myrtle Beach to San Diego that include hotel bookings?

    Yes. In addition to deals on Myrtle Beach to San Diego flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Myrtle Beach to San Diego?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Myrtle Beach to San Diego.

  • Can I find deals for business class flights from Myrtle Beach to San Diego?

    Yes. Cheapflights offers flight deals from Myrtle Beach to San Diego by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Myrtle Beach to San Diego?

    Currently, September is the cheapest month in which you can book a flight from Myrtle Beach to San Diego (average of $165). Flying from Myrtle Beach to San Diego in March is currently the most expensive (average of $294). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Traveling to a place near San Diego?

Book flights to San Diego if you plan to visit one of these locations
El Cajon
Chula Vista
National City
Coronado
La Mesa
Poway
Julian
Lemon Grove

Browse thousands of different options on Cheapflights for your next trip

Toggle through the tabs below to find thousands of options on Cheapflights for your next trip.

Alternative routes for Myrtle Beach to San Diego

See prices for flight routes from nearby airports that may be better suited for you.
Charlotte to Las Vegas flights
Charlotte to Los Angeles flights
Charlotte to San Francisco flights
Charlotte to San Diego flights
Charleston to Las Vegas flights
Charlotte to Ontario flights
Greenville to Las Vegas flights
Charlotte to Santa Ana flights
Myrtle Beach to Las Vegas flights
Columbia to Las Vegas flights
Savannah to Las Vegas flights
Charlotte to Burbank flights
Charleston to San Francisco flights
Charleston to Los Angeles flights
Charleston to San Diego flights
Augusta to Las Vegas flights
Charlotte to San Jose flights
Charlotte to Reno flights
Charlotte to Sacramento flights
Columbia to San Francisco flights
Greenville to Los Angeles flights
Greenville to San Francisco flights
Savannah to San Diego flights
Savannah to Los Angeles flights
Charlotte to Palm Springs flights
Augusta to Los Angeles flights
Columbia to Los Angeles flights
Savannah to San Francisco flights
Charlotte to Medford flights
Myrtle Beach to Los Angeles flights
Charlotte to Fresno flights
Charleston to Ontario flights
Greenville to Santa Ana flights
Greenville to San Diego flights
Savannah to Ontario flights
Charleston to Reno flights
Columbia to San Diego flights
Charleston to San Jose flights
Charlotte to Santa Barbara flights
Columbia to Ontario flights
Columbia to San Jose flights
Charlotte to Oakland flights
Greenville to San Jose flights
Charlotte to Long Beach flights
Myrtle Beach to Reno flights
Augusta to Santa Ana flights
Savannah to Reno flights
Charleston to Sacramento flights

Top 3 airlines flying from Myrtle Beach to San Diego

Discover the top 3 airlines that operate flights from Myrtle Beach to San Diego. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated March 13, 2026.
AirlineCheapestAverageFlexibilityOn-time
American AirlinesCheapest$274Average$441FlexibilityNo cancel feeOn-time71%
DeltaCheapest$331Average$526FlexibilityNo cancel feeOn-timeN/A
SouthwestCheapest$437Average$476FlexibilityNo cancel feeOn-time63%

100% Free

Cheapflights is completely free to use, so you can start saving the moment you arrive.

Book with Flexibility

Our users can plan ahead with confidence and find flights with no change fees

Travel Smart

Millions of people come to us for their flight needs every year. We help make travel planning easy by providing useful insights and data-driven graphs that can inform your decisions.
Site
Cookie settings©2026 Cheapflights