HomeSearch by dateVacation packagesHotelsFlight dealsCar rentalTravel tips & news
San Diego

$150+ Cheap flights from Myrtle Beach to San Diego (MYR - SAN)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 9/4. Fares are subject to change and may not be available on all flights or dates of travel.
MYR — SAN
Aug 3 — Aug 101
Sun 8/3
Sun 8/10
1 adult, Economy
We work with more than 300 partners to bring you better travel deals

Find cheap flights from Myrtle Beach to San Diego with Cheapflights

1. Tell us where you want to go

Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”

2. Select your favorite providers

We find the providers serving your travel needs. Choose up to four travel providers to compare side-by-side for flights, hotels, or car rentals.

3. Compare prices and book

Review each provider’s pricing and select the best option for you! Book through your favorite provider’s website for a seamless experience.

Cheapflights Tip: The best prices from Myrtle Beach Intl to San Diego are usually found in May or September, booked 71 days in advance, depart on a Tuesday or Friday and return on a Tuesday

Cheap flight deals from Myrtle Beach to San Diego

Discover tips and strategies to find the most affordable flight options for your journey from Myrtle Beach (MYR) to San Diego (SAN). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated July 29, 2025.

Round-trip from

$297
(Mytrip)

One-way from

$150
(Mytrip)

Popular in

June

Cheapest in

May

Average price

$476
From Myrtle Beach Intl to San Diego
Search Deals
One-way flight from Myrtle Beach Intl to San Diego
Search Deals
Highest demand for flights based on searches. 6% potential increase in price ($30 potential increase over avg. RT price).
Search Deals
Cheapest flight prices on average. 3% potential price decrease ($14 potential savings vs. average RT price).
Search Deals
Average for round-trip flights in July 2025
Search Deals

Find flight deals from Myrtle Beach to San Diego

Cheapest flights from Myrtle Beach to San Diego
Explore the most affordable flight options available from Myrtle Beach to San Diego. Find the lowest fares from popular airlines and budget airlines, with prices last updated on July 29, 2025.

This Mytrip deal was found by Cheapflights users on 7/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 8/286:50 amMYR - SAN
2 stops19h 47mSpirit Airlines
Wed 9/37:01 pmSAN - MYR
3 stops20h 26mSpirit Airlines
Deal found 7/28$304
This Delta deal was found by Cheapflights users on 7/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/86:58 pmMYR - SAN
1 stop7h 11mDelta
Tue 10/1410:20 pmSAN - MYR
1 stop9h 14mDelta
Deal found 7/27$333
This American Airlines deal was found by Cheapflights users on 7/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 8/319:19 amMYR - SAN
1 stop7h 16mAmerican Airlines
Sun 9/76:15 amSAN - MYR
1 stop7h 36mAmerican Airlines
Deal found 7/27$392
This Southwest deal was found by Cheapflights users on 7/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/88:25 amMYR - SAN
2 stops13h 25mSouthwest
Wed 10/156:40 amSAN - MYR
2 stops10h 15mSouthwest
Deal found 7/27$394
This United Airlines deal was found by Cheapflights users on 7/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 9/44:45 pmMYR - SAN
1 stop8h 17mUnited Airlines
Thu 9/119:45 pmSAN - MYR
2 stops9h 53mUnited Airlines
Deal found 7/27$432

Cheapflights Fare Finder

 
Customize your flight search to find flights from Myrtle Beach to San Diego that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated July 29, 2025.
Use the filters below to find and compare flights from Myrtle Beach to San Diego that are best for you.

Fly from

Myrtle Beach

Fly to

San Diego

Route

Depart

Return

Price

Myrtle BeachSan Diego

MYR - SAN

MYRSAN

Myrtle Beach Intl

Sat 8/16

6:45 am-11:37 pm

3 stops19h 52m

San Diego

Wed 8/20

1:17 pm-1:13 pm

2 stops20h 56m

$297

Myrtle BeachSan Diego

MYR - SAN

MYRSAN

Myrtle Beach Intl

Wed 10/8

6:58 pm-11:09 pm

1 stop7h 11m

San Diego

Tue 10/14

10:20 pm-10:34 am

1 stop9h 14m

$333

Myrtle BeachSan Diego

MYR - SAN

MYRSAN

Myrtle Beach Intl

Mon 8/25

9:40 pm-5:56 pm

2 stops23h 16m

San Diego

Fri 8/29

12:02 pm-3:55 pm

2 stops24h 53m

$340

Myrtle BeachSan Diego

MYR - SAN

MYRSAN

Myrtle Beach Intl

Thu 9/4

5:52 pm-10:36 pm

1 stop7h 44m

San Diego

Tue 9/9

10:32 pm-9:33 am

1 stop8h 01m

$349

Myrtle BeachSan Diego

MYR - SAN

MYRSAN

Myrtle Beach Intl

Thu 9/4

11:27 am-10:14 pm

2 stops13h 47m

San Diego

Tue 9/9

9:41 pm-10:39 am

1 stop9h 58m

$354

Myrtle BeachSan Diego

MYR - SAN

MYRSAN

Myrtle Beach Intl

Thu 9/4

6:00 pm-10:45 pm

1 stop7h 45m

San Diego

Mon 9/8

9:10 pm-9:55 am

1 stop9h 45m

$365

Myrtle BeachSan Diego

MYR - SAN

MYRSAN

Myrtle Beach Intl

Thu 9/4

1:11 pm-11:24 pm

2 stops13h 13m

$150

Myrtle BeachSan Diego

MYR - SAN

MYRSAN

Myrtle Beach Intl

Wed 10/29

7:00 am-12:04 pm

1 stop8h 04m

$167

Myrtle BeachSan Diego

MYR - SAN

MYRSAN

Myrtle Beach Intl

Sun 8/3

6:10 am-12:04 pm

2 stops32h 54m

$232

Myrtle BeachSan Diego

MYR - SAN

MYRSAN

Myrtle Beach Intl

Sun 10/26

4:30 pm-11:20 pm

2 stops9h 50m

$296

Flights are sorted by cheapest round-trip flights first.

Deals found on 7/26

Showing 1-10 of 11 results
1
2

Best time to book a flight from Myrtle Beach to San Diego

Have a flexible travel schedule? Discover the best time to fly to San Diego from Myrtle Beach with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Myrtle Beach to San Diego

How far ahead should I book a flight from Myrtle Beach to San Diego?

Use this chart to determine the optimal time to book a round-trip flight from Myrtle Beach to San Diego. Price data was last updated on July 25, 2025.

The best time to book flights from Myrtle Beach to San Diego is 70 days before your desired departure date. The cost of your flight will likely increase significantly if you book two weeks in advance of your flight.

What is the cheapest month to book a flight from Myrtle Beach to San Diego?

Currently, August is the cheapest month in which you can book a flight from Myrtle Beach to San Diego (average of $286). Flying from Myrtle Beach to San Diego in March is currently the most expensive (average of $366). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from MYR to SAN?

Find hourly flight availability from Myrtle Beach to San Diego. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated July 29, 2025.

When flying from Myrtle Beach to San Diego, the time of day you fly usually plays a role in the price. Save by searching for a flight at noon, which can drop the price by up to 13% versus a flight in the afternoon.

Reviews of airlines servicing San Diego

Get insights into the airlines that provide service to San Diego. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to San Diego. Reviews last updated July 29, 2025.
Get a feel of what it's like to fly with Southwest, Delta, and United Airlines from Myrtle Beach to San Diego by reading reviews from past customers. Users have also rated airlines in terms of entertainment options, comfort, food, crew/service, and boarding process.
Southwest
8.0
Very good
4,238 reviews

Overall

8.0

Entertainment

7.5

Food

7.0

Crew

8.6

Boarding

8.1

Comfort

8.0

Reviews

1 / 20
10.0
Excellent

Merlyn,Feb 2025

LAX - SMF

New Terminal is neat, lost of stores and places to catch a bite.
Southwest
8.0
Very good
4,238 reviews
Southwest
8.0
Very good
4,238 reviews

Overall

8.0

Entertainment

7.5

Food

7.0

Crew

8.6

Boarding

8.1

Comfort

8.0

Reviews

1 / 20
10.0
Excellent

Merlyn,Feb 2025

LAX - SMF

New Terminal is neat, lost of stores and places to catch a bite.
Delta
8.0
Very good
7,977 reviews
Southwest
8.0
Very good
4,238 reviews

Overall

8.0

Entertainment

7.5

Food

7.0

Crew

8.6

Boarding

8.1

Comfort

8.0

Reviews

1 / 20
10.0
Excellent

Merlyn,Feb 2025

LAX - SMF

New Terminal is neat, lost of stores and places to catch a bite.
United Airlines
7.4
Good
8,893 reviews
Southwest
8.0
Very good
4,238 reviews

Overall

8.0

Entertainment

7.5

Food

7.0

Crew

8.6

Boarding

8.1

Comfort

8.0

Reviews

1 / 20
10.0
Excellent

Merlyn,Feb 2025

LAX - SMF

New Terminal is neat, lost of stores and places to catch a bite.
American Airlines
7.2
Good
10,000 reviews
Southwest
8.0
Very good
4,238 reviews

Overall

8.0

Entertainment

7.5

Food

7.0

Crew

8.6

Boarding

8.1

Comfort

8.0

Reviews

1 / 20
10.0
Excellent

Merlyn,Feb 2025

LAX - SMF

New Terminal is neat, lost of stores and places to catch a bite.
Spirit Airlines
6.3
Okay
8,040 reviews
Southwest
8.0
Very good
4,238 reviews

Overall

8.0

Entertainment

7.5

Food

7.0

Crew

8.6

Boarding

8.1

Comfort

8.0

Reviews

1 / 20
10.0
Excellent

Merlyn,Feb 2025

LAX - SMF

New Terminal is neat, lost of stores and places to catch a bite.

Related info for your journey

Find useful and relevant information for your journey from Myrtle Beach to San Diego. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What are the cheapest airlines flying from Myrtle Beach to San Diego round-trip?

    Cheapflights users have booked flights from Myrtle Beach to San Diego round-trip from $297. Other airlines that can offer you cheap pricing are Delta, from $333, and American Airlines, from $349. Spirit Airlines is currently priced 35% below the average price you’ll pay for this route.

  • What are the cheapest airlines to fly from Myrtle Beach to San Diego one-way?

    To fly one-way, consider booking your trip with Spirit Airlines, which is currently one of the cheapest options available, starting at $150. American Airlines flights start at $167 while deals on Southwest start at $296 one-way.

  • Can I find deals for flights from Myrtle Beach to San Diego that include hotel bookings?

    Yes. In addition to deals on Myrtle Beach to San Diego flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Myrtle Beach to San Diego?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Myrtle Beach to San Diego.

  • Can I find deals for business class flights from Myrtle Beach to San Diego?

    Yes. Cheapflights offers flight deals from Myrtle Beach to San Diego by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Myrtle Beach to San Diego?

    Currently, August is the cheapest month in which you can book a flight from Myrtle Beach to San Diego (average of $286). Flying from Myrtle Beach to San Diego in March is currently the most expensive (average of $366). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Traveling to a place near San Diego?

Book flights to San Diego if you plan to visit one of these locations
El Cajon
Chula Vista
Coronado
Poway
National City
Lemon Grove
Imperial Beach
La Mesa
Alpine
Santee

Browse thousands of different options on Cheapflights for your next trip

Toggle through the tabs below to find thousands of options on Cheapflights for your next trip.

Alternative routes for Myrtle Beach to San Diego

See prices for flight routes from nearby airports that may be better suited for you.
Charlotte to Las Vegas flights
Charlotte to Los Angeles flights
Charleston to Las Vegas flights
Charlotte to San Francisco flights
Charleston to San Francisco flights
Charlotte to San Diego flights
Greenville to Las Vegas flights
Savannah to Las Vegas flights
Charlotte to Ontario flights
Augusta to Las Vegas flights
Greenville to Ontario flights
Greenville to Santa Ana flights
Charlotte to Burbank flights
Charlotte to Santa Ana flights
Greenville to Burbank flights
Charlotte to Sacramento flights
Columbia to Las Vegas flights
Myrtle Beach to Las Vegas flights
Charlotte to Reno flights
Greenville to Long Beach flights
Charlotte to Fresno flights
Savannah to Los Angeles flights
Savannah to San Diego flights
Greenville to San Diego flights
Charleston to Los Angeles flights
Charleston to San Diego flights
Charlotte to Palm Springs flights
Columbia to San Diego flights
Greenville to San Francisco flights
Charleston to Reno flights
Myrtle Beach to San Francisco flights
Myrtle Beach to Los Angeles flights
Savannah to Ontario flights
Columbia to Los Angeles flights
Columbia to San Francisco flights
Charlotte to San Jose flights
Savannah to Santa Ana flights
Greenville to San Jose flights
Greenville to Los Angeles flights
Charleston to Santa Ana flights
Savannah to San Francisco flights
Charleston to Ontario flights
Myrtle Beach to Ontario flights
Hilton Head Island to Las Vegas flights
Columbia to Ontario flights
Myrtle Beach to Reno flights
Charleston to Sacramento flights
Charlotte to Oakland flights
Greenville to Sacramento flights

Top 3 airlines flying from Myrtle Beach to San Diego

Discover the top 3 airlines that operate flights from Myrtle Beach to San Diego. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated July 29, 2025.
AirlineCheapestAverageFlexibilityOn-time
American AirlinesCheapest$331Average$439FlexibilityNo cancel feeOn-time71%
DeltaCheapest$331Average$431FlexibilityNo cancel feeOn-timeN/A
SouthwestCheapest$437Average$492FlexibilityNo cancel feeOn-time63%

100% Free

Cheapflights is completely free to use, so you can start saving the moment you arrive.

Book with Flexibility

Our users can plan ahead with confidence and find flights with no change fees

Travel Smart

Millions of people come to us for their flight needs every year. We help make travel planning easy by providing useful insights and data-driven graphs that can inform your decisions.