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$129+ Cheap flights from Key Largo, FL to San Diego (SAN)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 9/23. Fares are subject to change and may not be available on all flights or dates of travel.
MIA — SAN
Jul 5 — Jul 121
Sat 7/5
Sat 7/12
1 adult, Economy
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Cheapflights Tip: The best prices from Key Largo to San Diego are usually found in April or May, booked 74 days in advance, depart on a Wednesday or Thursday and return on a Tuesday

Cheap flight deals from Key Largo to San Diego

Keep the following information in mind while searching for Key Largo to San Diego flight deals. Data was last updated June 30, 2025.

Round-trip from

$242
(Frontier)

One-way from

$130
(Frontier)

Popular in

March

Cheapest in

April

Average price

$437
From Key Largo to San Diego
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One-way flight from Key Largo to San Diego
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High demand for flights, 1% potential price rise
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Cheapest flight prices on average. 1% potential price decrease ($5 potential savings vs. average RT price).
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Average for round-trip flights in June 2025
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Find flight deals from Key Largo to San Diego

Cheapest flights from Key Largo to San Diego
Explore the most affordable flight options available from Key Largo to San Diego. Find the lowest fares from popular airlines and budget airlines, with prices last updated on June 30, 2025.

This Frontier deal was found by Cheapflights users on 6/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Frontier is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 8/226:00 amMIA - SAN
1 stop7h 53mFrontier
Mon 8/256:25 amSAN - MIA
2 stops15h 29mFrontier
Deal found 6/30$242
This Justfly.com deal was found by Cheapflights users on 6/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Justfly.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/236:00 amMIA - SAN
1 stop8h 08mMultiple Airlines
Sun 10/2611:40 amSAN - MIA
1 stop25h 16mMultiple Airlines
Deal found 6/30$243
This Mytrip deal was found by Cheapflights users on 6/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/246:28 pmMIA - SAN
1 stop15h 53mSpirit Airlines
Mon 9/291:32 pmSAN - MIA
2 stops22h 07mSpirit Airlines
Deal found 6/30$244
This Alaska Airlines deal was found by Cheapflights users on 6/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Alaska Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 8/126:20 pmMIA - SAN
1 stop17h 33mAlaska Airlines
Tue 8/198:45 pmSAN - MIA
1 stop17h 46mAlaska Airlines
Deal found 6/28$256
This Delta deal was found by Cheapflights users on 6/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/812:10 pmMIA - SAN
1 stop9h 16mDelta
Sat 10/116:15 amSAN - MIA
1 stop8h 09mDelta
Deal found 6/30$257

Cheapflights Fare Finder

Customize your flight search to find flights from Key Largo to San Diego that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated June 30, 2025.
Use the filters below to find and compare flights from Key Largo to San Diego that are best for you.

Fly from

Key Largo

Fly to

San Diego

Route

Depart

Return

Price

MiamiSan Diego

MIA - SAN

MIASAN

Miami

Fri 8/22

6:00 am-10:53 am

1 stop7h 53m

San Diego

Mon 8/25

6:25 am-12:54 am

2 stops15h 29m

$242

MiamiSan Diego

MIA - SAN

MIASAN

Miami

Thu 10/23

6:00 am-11:08 am

1 stop8h 08m

San Diego

Sun 10/26

11:40 am-3:56 pm

1 stop25h 16m

$243

MiamiSan Diego

MIA - SAN

MIASAN

Miami

Wed 9/24

6:28 pm-7:21 am

1 stop15h 53m

San Diego

Mon 9/29

1:32 pm-2:39 pm

2 stops22h 07m

$244

MiamiSan Diego

MIA - SAN

MIASAN

Miami

Tue 8/12

6:20 pm-8:53 am

1 stop17h 33m

San Diego

Tue 8/19

8:45 pm-5:31 pm

1 stop17h 46m

$256

MiamiSan Diego

MIA - SAN

MIASAN

Miami

Wed 10/8

12:10 pm-6:26 pm

1 stop9h 16m

San Diego

Wed 10/15

7:12 pm-6:07 am

1 stop7h 55m

$257

MiamiSan Diego

MIA - SAN

MIASAN

Miami

Tue 9/23

12:23 pm-6:00 pm

1 stop8h 37m

$129

MiamiSan Diego

MIA - SAN

MIASAN

Miami

Thu 8/14

7:43 am-6:19 pm

2 stops13h 36m

$130

MiamiSan Diego

MIA - SAN

MIASAN

Miami

Tue 9/30

3:35 pm-11:41 pm

2 stops11h 06m

$134

MiamiSan Diego

MIA - SAN

MIASAN

Miami

Sun 7/13

7:00 am-11:06 pm

1 stop19h 06m

$135

MiamiSan Diego

MIA - SAN

MIASAN

Miami

Wed 9/3

7:40 pm-9:58 pm

Nonstop5h 18m

$174

Flights are sorted by cheapest round-trip flights first.

Deals found on 6/30

Showing 1-10 of 11 results
1
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Best time to book a flight from Key Largo to San Diego

Have a flexible travel schedule? Discover the best time to fly to San Diego from Key Largo with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Key Largo to San Diego

How far ahead should I book a flight from Key Largo to San Diego?

Use this chart to determine the optimal time to book a round-trip flight from Key Largo to San Diego. Price data was last updated on June 27, 2025.

To ensure you get the cheapest price possible for a flight from Key Largo to San Diego, you should look to book at least 74 days in advance of your intended travel date. The price of your flight may increase if you delay and leave booking until a week or so before departure.

What is the cheapest month to book a flight from Key Largo to San Diego?

Currently, August is the cheapest month in which you can book a flight from Key Largo to San Diego (average of $286). Flying from Key Largo to San Diego in March is currently the most expensive (average of $366). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from KE9 to SAN?

Find hourly flight availability from Key Largo to San Diego. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated June 30, 2025.

When flying from Key Largo to San Diego, the time of day you decide to fly out makes little to no difference towards the overall price you’ll pay on tickets.

What is the cheapest day to fly from Key Largo to San Diego?

Use this chart to determine the cheapest time to fly round-trip from Key Largo to San Diego. Price data was last updated on December 16, 2024.

Travelers seeking maximum savings on their Key Largo to San Diego flight should consider departing on Tuesday at noon when fares are most often at their lowest. Sunday afternoons flights should be avoided if possible as fares are typically the most expensive at this time.

Weekly flight availability from Key Largo to San Diego

Explore weekly flight availability from Key Largo to San Diego. Discover flights operating on different days of the week, giving you the flexibility to choose a travel day that best fits your plans. Compare info to find the most convenient option for your journey. Data last updated June 30, 2025.

The most flights from KE9 to SAN are scheduled on a Saturday (5 on average). You will have fewer flight options on Monday, which is when the least amount of flights are scheduled (4 on average).

How much does it cost to fly round-trip from Key Largo to San Diego?

Reviews of airlines servicing San Diego

Get insights into the airlines that provide service to San Diego. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to San Diego. Reviews last updated June 30, 2025.
Read through reviews of airlines operating flights from Key Largo to San Diego, such as Alaska Airlines, United Airlines, and Spirit Airlines. Reviews also offer insight into each airline's entertainment options, comfort, food, crew/service, and boarding process.
Alaska Airlines
8.0
Very good
10,000 reviews

Crew

8.5

Boarding

8.1

Comfort

7.8

Overall

8.0

Entertainment

7.1

Food

7.1

Reviews

1 / 20
10.0
Excellent

James,Apr 2025

LAX - SFO

Good flight except the uncontrollable cold air from the ceiling.
Alaska Airlines
8.0
Very good
10,000 reviews
Alaska Airlines
8.0
Very good
10,000 reviews

Crew

8.5

Boarding

8.1

Comfort

7.8

Overall

8.0

Entertainment

7.1

Food

7.1

Reviews

1 / 20
10.0
Excellent

James,Apr 2025

LAX - SFO

Good flight except the uncontrollable cold air from the ceiling.
United Airlines
7.4
Good
8,852 reviews
Alaska Airlines
8.0
Very good
10,000 reviews

Crew

8.5

Boarding

8.1

Comfort

7.8

Overall

8.0

Entertainment

7.1

Food

7.1

Reviews

1 / 20
10.0
Excellent

James,Apr 2025

LAX - SFO

Good flight except the uncontrollable cold air from the ceiling.
Spirit Airlines
6.3
Okay
8,094 reviews
Alaska Airlines
8.0
Very good
10,000 reviews

Crew

8.5

Boarding

8.1

Comfort

7.8

Overall

8.0

Entertainment

7.1

Food

7.1

Reviews

1 / 20
10.0
Excellent

James,Apr 2025

LAX - SFO

Good flight except the uncontrollable cold air from the ceiling.
Frontier
5.9
Fair
3,290 reviews
Alaska Airlines
8.0
Very good
10,000 reviews

Crew

8.5

Boarding

8.1

Comfort

7.8

Overall

8.0

Entertainment

7.1

Food

7.1

Reviews

1 / 20
10.0
Excellent

James,Apr 2025

LAX - SFO

Good flight except the uncontrollable cold air from the ceiling.

Related info for your journey

Find useful and relevant information for your journey from Key Largo to San Diego. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airport do you fly into for flights to San Diego from Key Largo?

    If you book a flight to San Diego from Key Largo, you will be flying to San Diego, which is the city’s only airport. San Diego (SAN) is located 2.6 mi from the center of San Diego. There are 4 flights from Key Largo to San Diego per day from 9 different airlines.

  • How popular is this Key Largo to San Diego flight route?

    The Key Largo to San Diego flight path was viewed by 2 users in the past month. Keep an eye out for changes in search interest prior to high and low season.

  • What are the cheapest airlines to fly from Key Largo to San Diego one-way?

    The cheapest airline one-way is Frontier, with whom users have recently found tickets for as low as $130. However, be on the lookout for offers from United Airlines and Spirit Airlines, as they are both options that can get you from Key Largo to San Diego for a low price.

  • What are the most reliable airlines from Key Largo to San Diego?

    Before booking your flight to San Diego from Key Largo, check out the most reliable airlines to get you to your destination on time: American Airlines (73%), Alaska Airlines (73%), GOL( 73%).

  • What are the cheapest flights from Key Largo to San Diego?

    Looking for the cheapest flight from Key Largo to San Diego? While on average our users pay $1,038, our data indicates the cheapest price to be $173. The most popular route (Miami - San Diego), is priced around $151.

  • Can I find deals for flights from Key Largo to San Diego that include hotel bookings?

    Yes. In addition to deals on Key Largo to San Diego flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Key Largo to San Diego?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Key Largo to San Diego.

  • Can I find deals for business class flights from Key Largo to San Diego?

    Yes. Cheapflights offers flight deals from Key Largo to San Diego by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Key Largo to San Diego?

    Currently, August is the cheapest month in which you can book a flight from Key Largo to San Diego (average of $286). Flying from Key Largo to San Diego in March is currently the most expensive (average of $366). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Traveling to a place near Key Largo?

Book flights to Key Largo if you plan to visit one of these locations
El Cajon
Chula Vista
Coronado
National City
Lemon Grove
Imperial Beach
La Mesa
Poway
Alpine
Santee

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Top 9 airlines flying from Key Largo to San Diego

Discover the top 9 airlines that operate flights from Key Largo to San Diego. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated June 30, 2025.
AirlineCheapestAverageFlexibilityOn-time
Spirit AirlinesCheapest$135Average$230FlexibilityNo cancel feeOn-time65%
FrontierCheapest$138Average$195FlexibilityNo cancel feeOn-time62%
JetBlueCheapest$166Average$340FlexibilityNo cancel feeOn-time62%
Alaska AirlinesCheapest$196Average$463FlexibilityNo cancel feeOn-time75%
American AirlinesCheapest$197Average$396FlexibilityNo cancel feeOn-time71%
DeltaCheapest$204Average$332FlexibilityNo cancel feeOn-timeN/A
United AirlinesCheapest$236Average$381FlexibilityNo cancel feeOn-time69%
Hawaiian AirlinesCheapest$237Average$398FlexibilityNo cancel feeOn-time85%
SouthwestCheapest$266Average$399FlexibilityNo cancel feeOn-time63%

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